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Lee-Jun Wong

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Hong Cui; Gregory M Enns; Brett Graham; Megan L Landsverk; Fangyuan Li; Margherita Milone; Cavatina Truong; Guoli Wang; Jing Wang; David Chen; Wei Zhang; Lee-Jun C Wong
Comprehensive next-generation sequence analyses of the entire mitochondrial genome reveal new insights into the molecular diagnosis of mitochondrial DNA disorders.
Lee-Jun C Wong
Challenges of bringing next generation sequencing technologies to clinical molecular diagnostic laboratories.
Benny Abraham Kaipparettu; Tin-Lap Lee; Yewei Ma; Jun Hyoung Park; Wai-Yee Chan; Chad J Creighton; Patricia Yotnda; Yiqun Zhang; Lee-Jun C Wong
Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways.

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2013: Hong Cui; Gregory M Enns; Brett Graham; Megan L Landsverk; Fangyuan Li; Margherita Milone; Cavatina Truong; Guoli Wang; Jing Wang; David Chen; Wei Zhang; Lee-Jun C Wong
Comprehensive next-generation sequence analyses of the entire mitochondrial genome reveal new insights into the molecular diagnosis of mitochondrial DNA disorders.
Genetics in medicine : official journal of the American College of Medical Genetics 2013;15(5):388-94.
2013: Lee-Jun C Wong
Challenges of bringing next generation sequencing technologies to clinical molecular diagnostic laboratories.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2013;10(2):262-72.
2013: Benny Abraham Kaipparettu; Tin-Lap Lee; Yewei Ma; Jun Hyoung Park; Wai-Yee Chan; Chad J Creighton; Patricia Yotnda; Yiqun Zhang; Lee-Jun C Wong
Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways.
PloS one 2013;8(5):e61747.
2012: Megan L Landsverk; Sha Tang; Guo-Li Wang; Jing Wang; Ganka V Douglas; Victor W Zhang; Lee-Jun C Wong
Diagnostic approaches to apparent homozygosity.
Genetics in medicine : official journal of the American College of Medical Genetics 2012;14(10):877-82.
2012: Wei Zhang; Hong Cui; Lee-Jun C Wong
Comprehensive one-step molecular analyses of mitochondrial genome by massively parallel sequencing.
Clinical chemistry 2012;58(9):1322-31.
2012: Yu-Chuan Hsu; Cherng-Lih Perng; An-Chen Tso; Lee-Jun C Wong; Fu-Chi Yang; Chang-Hung Hsu
Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome presenting as acute meningoencephalitis: a case report.
The Journal of emergency medicine 2012;43(3):e163-6.
2012: Rami Massie; Li-Chieh Chen; Michael P Collins; Jing Wang; Lee-Jun C Wong; Victor W Zhang; Margherita Milone
Mitochondrial myopathy due to novel missense mutation in the cytochrome c oxidase 1 gene.
Journal of the neurological sciences 2012;319(1-2):158-63.
2012: Georgianne L Arnold; Annet M Bosch; Roberto Cerone; Kristina Cusmano-Ozog; Gregory M Enns; Brett H Graham; Brendan C Lanpher; Paul Levy; Uta Lichter-Konecki; Mark H Lipson; Julie A Neidich; Natalie N Owen; Denise Salazar; Pim Suwannarat; Lee-Jun C Wong; Erica L Wright; Antal Dezsőfi
Outcome of infants diagnosed with 3-methyl-crotonyl-CoA-carboxylase deficiency by newborn screening.
Molecular genetics and metabolism 2012;106(4):439-41.
2012: Inn-Chi Lee; Fang-Yuan Li; Jing Wang; Shao-Wen Weng; William J Craigen; Ayman W El-Hattab; Lee-Jun C Wong
SURF1-associated Leigh syndrome: a case series and novel mutations.
Human mutation 2012;33(8):1192-200.
2012: Jing Wang; Victor Wei Zhang; William J Craigen; Brett H Graham; Megan L Landsverk; Fang-Yuan Li; Eric S Schmitt; Lee-Jun C Wong
An integrated approach for classifying mitochondrial DNA variants: one clinical diagnostic laboratory's experience.
Genetics in medicine : official journal of the American College of Medical Genetics 2012;14(6):620-6.
2012: Reza Bekheirnia; Tanya Eble; Fernando Scaglia; Aziz Shaibani; Alecia Willis; Lee-Jun C Wong; Wei Zhang; Shweta U Dhar
POLG mutation in a patient with cataracts, early-onset distal muscle weakness and atrophy, ovarian dysgenesis and 3-methylglutaconic aciduria.
Gene 2012;499(1):209-12.
2012: Brian York; H Yu; Suoling Zhou; Adekunle M Adesina; Xian Chen; Atul R Chopra; Susan Hilsenbeck; Olga Ilkayeva; Jean-Francois Louet; Christopher B Newgard; Bryan C Nikolai; Jeffrey Noebels; Graham Reed; Erin L Reineke; Jørn V Sagen; Robert D Stevens; Anna Tsimelzon; Brett R Wenner; Lee-Jun C Wong; Jianming Xu; Bert W O'Malley
Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.
Cell metabolism 2012;15(5):752-63.
2012: Sha Tang; Elliot L Dimberg; Margherita Milone; Lee-Jun C Wong
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)-like phenotype: an expanded clinical spectrum of POLG1 mutations.
Journal of neurology 2012;259(5):862-8.
2012: Ayman W El-Hattab; Lisa T Emrick; Jean W Hsu; Farook Jahoor; William J Craigen; Lee-Jun C Wong; Fernando Scaglia
Restoration of impaired nitric oxide production in MELAS syndrome with citrulline and arginine supplementation.
Molecular genetics and metabolism 2012;105(4):607-14.
2012: Lee-Jun C Wong
Mitochondrial syndromes with leukoencephalopathies.
Seminars in neurology 2012;32(1):55-61.
2012: Vlad C Sandulache; Heath Devin Skinner; Lee-Jun C Wong; Xuefeng Xia; Aijun Zhang; Ge Zhou; James M Luchak; Thomas J Ow; Curtis R Pickering; Jeffrey N Myers
Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status.
Cancer 2012;118(3):711-21.
2011: Sha Tang; Jing Wang; Wei Zhang; William J Craigen; Michelle C Halberg; Ni-Chung Lee; Margherita Milone; Eric S Schmitt; Lee-Jun C Wong
Mitochondrial DNA polymerase gamma mutations: an ever expanding molecular and clinical spectrum.
Journal of medical genetics 2011;48(10):669-81.
2011: Yi-Fang Tu; Benny A Kaipparettu; Yewei Ma; Lee-Jun C Wong
Mitochondria of highly metastatic breast cancer cell line MDA-MB-231 exhibits increased autophagic properties.
Biochimica et biophysica acta 2011;1807(9):1125-32.
2011: Neil A Hanchard; Saul J Karpen; Edwina J Popek; Angshumoy Roy; Oleg A Shchelochkov; Jing Wang; Joanna Wiszniewska; Lee-Jun C Wong; Fernando Scaglia
Deoxyguanosine kinase deficiency presenting as neonatal hemochromatosis.
Molecular genetics and metabolism 2011;103(3):262-7.
2011: Megan L Landsverk; Jing Wang; Eric S Schmitt; Amber N Pursley; Lee-Jun C Wong
Utilization of targeted array comparative genomic hybridization, MitoMet, in prenatal diagnosis of metabolic disorders.
Molecular genetics and metabolism 2011;103(2):148-52.
2011: Gary Fruhman; Megan L Landsverk; Timothy E Lotze; Jill V Hunter; Michael F Wangler; Adekunle M Adesina; Lee-Jun C Wong; Fernando Scaglia
Atypical presentation of Leigh syndrome associated with a Leber hereditary optic neuropathy primary mitochondrial DNA mutation.
Molecular genetics and metabolism 2011;103(2):153-60.
2011: Nicola Brunetti-Pierri; Ricardo Pignatelli; Negin Fouladi; Jeffrey A Towbin; John W Belmont; William J Craigen; Lee-Jun C Wong; John L Jefferies; Fernando Scaglia
Dilation of the aortic root in mitochondrial disease patients.
Molecular genetics and metabolism 2011;103(2):167-70.
2011: Jeffrey M Gelfand; Jacque L Duncan; Caroline A Racine; Leslie A Gillum; Cynthia T Chin; Yuhua Zhang; Qing Zhang; Lee-Jun C Wong; Austin Roorda; Ari J Green
Heterogeneous patterns of tissue injury in NARP syndrome.
Journal of neurology 2011;258(3):440-8.
2011: Linda M Randolph; Hollie A Jackson; Jing Wang; Hiroyuki Shimada; Pedro A Sanchez-Lara; Derek A Wong; Lee-Jun C Wong; Richard G Boles
Fatal infantile lactic acidosis and a novel homozygous mutation in the SUCLG1 gene: a mitochondrial DNA depletion disorder.
Molecular genetics and metabolism 2011;102(2):149-52.
2011: Ren-Kui Bai; Julia Chang; Hao Liu; Mary Ann Lou; Jyh-Feng Lu; Duan-Jun Tan; Kun-Tu Yeh; Lee-Jun C Wong
Mitochondrial DNA content varies with pathological characteristics of breast cancer.
Journal of oncology 2011;2011():496189.
2011: Victor Venegas; Jing Wang; David Dimmock; Lee-Jun C Wong
Real-time quantitative PCR analysis of mitochondrial DNA content.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2011;Chapter 19():Unit 19.7..
2011: Jing Wang; Victor Venegas; Fangyuan Li; Lee-Jun C Wong
Analysis of mitochondrial DNA point mutation heteroplasmy by ARMS quantitative PCR.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2011;Chapter 19():Unit 19.6..
2011: Jing Wang; Oleg A Shchelochkov; Hongli Zhan; Fangyuan Li; Li-Chieh Chen; Ellen K Brundage; Amber N Pursley; Eric S Schmitt; Johannes Häberle; Lee-Jun C Wong
Molecular characterization of CPS1 deletions by array CGH.
Molecular genetics and metabolism 2011;102(1):103-6.
2011: Alison G Compton; Christopher Troedson; Meredith Wilson; Peter G Procopis; Fang-Yuan Li; Ellen K Brundage; Taro Yamazaki; David R Thorburn; Lee-Jun C Wong
Application of oligonucleotide array CGH in the detection of a large intragenic deletion in POLG associated with Alpers Syndrome.
Mitochondrion 2011;11(1):104-7.
2010: Oleg A Shchelochkov; Fang-Yuan Li; Jing Wang; Hongli Zhan; Jeffrey A Towbin; John Lynn Jefferies; Lee-Jun C Wong; Fernando Scaglia
Milder clinical course of Type IV 3-methylglutaconic aciduria due to a novel mutation in TMEM70.
Molecular genetics and metabolism 2010;101(2-3):282-5.
2010: Benny Abraham Kaipparettu; Yewei Ma; Lee-Jun C Wong
Functional effects of cancer mitochondria on energy metabolism and tumorigenesis: utility of transmitochondrial cybrids.
Annals of the New York Academy of Sciences 2010;1201():137-46.
2010: Rami Massie; Lee-Jun C Wong; Margherita Milone
Exercise intolerance due to cytochrome b mutation.
Muscle & nerve 2010;42(1):136-40.
2010: Curtis R Coughlin; Ian D Krantz; Eric S Schmitt; Shulin Zhang; Lee-Jun C Wong; Douglas S Kerr; Jaya Ganesh
Somatic mosaicism for PDHA1 mutation in a male with pyruvate dehydrogenase complex deficiency.
Molecular genetics and metabolism 2010;100(3):296-9.
2010: David Dimmock; Lin-Ya Tang; Eric S Schmitt; Lee-Jun C Wong
Quantitative evaluation of the mitochondrial DNA depletion syndrome.
Clinical chemistry 2010;56(7):1119-27.
2010: Lee-Jun C Wong
Molecular genetics of mitochondrial disorders.
Developmental disabilities research reviews 2010;16(2):154-62.
2010: Lee-Jun C Wong; Fernando Scaglia; Brett H Graham; William J Craigen
Current molecular diagnostic algorithm for mitochondrial disorders.
Molecular genetics and metabolism 2010;100(2):111-7.
2010: Russell P Saneto; Inn-Chi Lee; Mary Kay Koenig; Xinhua Bao; Shao-Wen Weng; Robert K Naviaux; Lee-Jun C Wong
POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders.
Seizure : the journal of the British Epilepsy Association 2010;19(3):140-6.
2010: Suh-Hang H Juo; Ming-Ying Lu; Ren-Kui Bai; Yi-Chu Liao; Robert B Trieu; Ming-Lung Yu; Lee-Jun C Wong
A common mitochondrial polymorphism 10398A>G is associated metabolic syndrome in a Chinese population.
Mitochondrion 2010;10(3):294-9.
2010: Ayman W El-Hattab; Fang-Yuan Li; Eric Schmitt; Shulin Zhang; William J Craigen; Lee-Jun C Wong
MPV17-associated hepatocerebral mitochondrial DNA depletion syndrome: new patients and novel mutations.
Molecular genetics and metabolism 2010;99(3):300-8.
2010: Poonam Sansanwal; Benedict Yen; William A Gahl; Yewei Ma; Lihua Ying; Lee-Jun C Wong; Minnie M Sarwal
Mitochondrial autophagy promotes cellular injury in nephropathic cystinosis.
Journal of the American Society of Nephrology : JASN 2010;21(2):272-83.
2010: bekim sadikovic; Jing Wang; Ayman El-Hattab; Megan Landsverk; Ganka Douglas; Ellen K Brundage; William J Craigen; Eric S Schmitt; Lee-Jun C Wong
Sequence homology at the breakpoint and clinical phenotype of mitochondrial DNA deletion syndromes.
PloS one 2010;5(12):e15687.
2010: Shulin Zhang; Fang-Yuan Li; Harold N Bass; Amber Pursley; Eric S Schmitt; Blaire L Brown; Ellen K Brundage; Rebecca Mardach; Lee-Jun C Wong
Application of oligonucleotide array CGH to the simultaneous detection of a deletion in the nuclear TK2 gene and mtDNA depletion.
Molecular genetics and metabolism 2010;99(1):53-7.
2010: Yewei Ma; Ren-Kui Bai; Robert Trieu; Lee-Jun C Wong
Mitochondrial dysfunction in human breast cancer cells and their transmitochondrial cybrids.
Biochimica et biophysica acta 2010;1797(1):29-37.
2009: A Craig Chinault; Chad A Shaw; Ellen K Brundage; Lin-Ya Tang; Lee-Jun C Wong
Application of dual-genome oligonucleotide array-based comparative genomic hybridization to the molecular diagnosis of mitochondrial DNA deletion and depletion syndromes.
Genetics in medicine : official journal of the American College of Medical Genetics 2009;11(7):518-26.
2009: Joseph T C Shieh; William E Berquist; Qing Zhang; Ping-Chieh Chou; Lee-Jun C Wong; Gregory M Enns
Novel deoxyguanosine kinase gene mutations and viral infection predispose apparently healthy children to fulminant liver failure.
Journal of pediatric gastroenterology and nutrition 2009;49(1):130-2.
2009: Margherita Milone; Brian R Younge; Jing Wang; Shulin Zhang; Lee-Jun C Wong
Mitochondrial disorder with OPA1 mutation lacking optic atrophy.
Mitochondrion 2009;9(4):279-81.
2009: Richard E Lutz; David Dimmock; Eric S Schmitt; Qing Zhang; Lin-Ya Tang; Christine Reyes; Edward Truemper; Rodney D McComb; Angel Hernandez; Alice Basinger; Lee-Jun C Wong
De novo mutations in POLG presenting with acute liver failure or encephalopathy.
Journal of pediatric gastroenterology and nutrition 2009;49(1):126-9.
2009: Johan L K Van Hove; Vicki Cunningham; Cathlin Rice; Steven P Ringel; Qing Zhang; Ping-Chieh Chou; Cavatina K Truong; Lee-Jun C Wong
Finding twinkle in the eyes of a 71-year-old lady: a case report and review of the genotypic and phenotypic spectrum of TWINKLE-related dominant disease.
American journal of medical genetics. Part A 2009;149A(5):861-7.
2009: Michael K Yoon; Austin Roorda; Yuhua Zhang; Chiaki Nakanishi; Lee-Jun C Wong; Qing Zhang; Leslie Gillum; Ari Green; Jacque L Duncan
Adaptive optics scanning laser ophthalmoscopy images in a family with the mitochondrial DNA T8993C mutation.
Investigative ophthalmology & visual science 2009;50(4):1838-47.
2009: B C Mobley; Gregory M Enns; Lee-Jun C Wong; Hannes Vogel
A novel homozygous SCO2 mutation, p.G193S, causing fatal infantile cardioencephalomyopathy.
Clinical neuropathology 2009;28(2):143-9.
2009: Oleg Shchelochkov; Lee-Jun C Wong; Aziz Shaibani; Marwan Shinawi
Atypical presentation of VLCAD deficiency associated with a novel ACADVL splicing mutation.
Muscle & nerve 2009;39(3):374-82.
2009: Oleg A Shchelochkov; Fang-Yuan Li; Michael T Geraghty; Renata C Gallagher; Johan L Van Hove; U Lichter-Konecki; Paul M FERNHOFF; Sara Copeland; Tyler Reimschisel; Stephen Cederbaum; Brendan Lee; A Craig Chinault; Lee-Jun C Wong
High-frequency detection of deletions and variable rearrangements at the ornithine transcarbamylase (OTC) locus by oligonucleotide array CGH.
Molecular genetics and metabolism 2009;96(3):97-105.
2009: Jing Wang; Ariel Brautbar; Alicia K Chan; Tara Dzwiniel; Fang-Yuan Li; Paula J Waters; Brett H Graham; Lee-Jun C Wong
Two mtDNA mutations 14487T>C (M63V, ND6) and 12297T>C (tRNA Leu) in a Leigh syndrome family.
Molecular genetics and metabolism 2009;96(2):59-65.
2008: Lee-Jun C Wong; Robert K Naviaux; Nicola Brunetti-Pierri; Qing Zhang; Eric S Schmitt; Cavatina Truong; Margherita Milone; Bruce Howard Cohen; Beverly Wical; Jai Ganesh; Alice A Basinger; Barbara K Burton; Kathryn Swoboda; Donald L Gilbert; Adeline Vanderver; Russell P Saneto; Bruno Maranda; Georgianne Arnold; Jose E Abdenur; Paula J Waters; William C Copeland
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations.
Human mutation 2008;29(9):E150-72.
2008: Margherita Milone; Nicola Brunetti-Pierri; Lin-Ya Tang; Neeraj Kumar; Michelle M Mezei; Keith A Josephs; Suzanne Powell; Ericka Simpson; Lee-Jun C Wong
Sensory ataxic neuropathy with ophthalmoparesis caused by POLG mutations.
Neuromuscular disorders : NMD 2008;18(8):626-32.
2008: Ariel Brautbar; Jing Wang; Jose E Abdenur; Richard C Chang; Janet A Thomas; Theresa A Grebe; Cynthia Lim; Shao-Wen Weng; Brett H Graham; Lee-Jun C Wong
The mitochondrial 13513G>A mutation is associated with Leigh disease phenotypes independent of complex I deficiency in muscle.
Molecular genetics and metabolism 2008;94(4):485-90.
2008: Lee-Jun C Wong; David Dimmock; Michael T Geraghty; Richard Quan; U Lichter-Konecki; Jing Wang; Ellen K Brundage; Fernando Scaglia; A Craig Chinault
Utility of oligonucleotide array-based comparative genomic hybridization for detection of target gene deletions.
Clinical chemistry 2008;54(7):1141-8.
2008: Nicola Brunetti-Pierri; K Selby; M O'Sullivan; G Hendson; Cavatina Truong; P J Waters; Lee-Jun C Wong
Rapidly progressive neurological deterioration in a child with Alpers syndrome exhibiting a previously unremarkable brain MRI.
Neuropediatrics 2008;39(3):179-83.
2008: Xinhua Bao; Ye Wu; Lee-Jun C Wong; Yuehua Zhang; Hui Xiong; Ping-Chieh Chou; Cavatina K Truong; Yuwu Jiang; Jiong Qin; Yun Yuan; Qing Lin; Xiru Wu
Alpers syndrome with prominent white matter changes.
Brain & development 2008;30(4):295-300.
2008: D P Dimmock; Q Zhang; Carlo Dionisi Vici; Rosalba Carrozzo; J Shieh; L-Y Tang; Cavatina Truong; E Schmitt; M Sifry-Platt; Simona Lucioli; Filippo M Santorelli; Can Ficicioglu; M Rodriguez; Klaas Jan Wierenga; Gregory M Enns; Nicola Longo; MH Lipson; Hilary D Vallance; William J Craigen; Fernando Scaglia; Lee-Jun C Wong
Clinical and molecular features of mitochondrial DNA depletion due to mutations in deoxyguanosine kinase.
Human mutation 2008;29(2):330-1.
2008: Fernando Scaglia; Lee-Jun C Wong
Human mitochondrial transfer RNAs: role of pathogenic mutation in disease.
Muscle & nerve 2008;37(2):150-71.
2008: Pu Dai; Yongyi Yuan; Deliang Huang; Xiuhui Zhu; Fei Yu; Dongyang Kang; Huijun Yuan; Bailin Wu; Dongyi Han; Lee-Jun C Wong
Molecular etiology of hearing impairment in Inner Mongolia: mutations in SLC26A4 gene and relevant phenotype analysis.
Journal of translational medicine 2008;6():74.
2008: Daniel Covarrubias; Ren-Kui Bai; Lee-Jun C Wong; Suzanne M Leal
Mitochondrial DNA variant interactions modify breast cancer risk.
Journal of human genetics 2008;53(10):924-8.
2007: Lee-Jun C Wong; Mei-Hui Lee; Ming Chen; Özgül M Alper; Lon-Yen Tsao; Bao-Tyan Wang
First prenatal exclusion of cystic fibrosis in East Asia.
Pediatrics international : official journal of the Japan Pediatric Society 2007;49(5):686-7.
2007: Lee-Jun C Wong; Nicola Brunetti-Pierri; Qing Zhang; Nada Yazigi; Kevin E Bove; Beverly B Dahms; Michelle A Puchowicz; Ignacio Gonzalez-Gomez; Eric S Schmitt; Cavatina K Truong; Charles L Hoppel; Ping-Chieh Chou; Jing Wang; Erin E Baldwin; Darius Adams; Nancy Leslie; Richard G Boles; Douglas S Kerr; William J Craigen
Mutations in the MPV17 gene are responsible for rapidly progressive liver failure in infancy.
Hepatology (Baltimore, Md.) 2007;46(4):1218-27.
2007: Lee-Jun C Wong
Pathogenic mitochondrial DNA mutations in protein-coding genes.
Muscle & nerve 2007;36(3):279-93.
2007: Ren-Kui Bai; Suzanne M Leal; Daniel Covarrubias; Aiyi Liu; Lee-Jun C Wong
Mitochondrial genetic background modifies breast cancer risk.
Cancer research 2007;67(10):4687-94.
2007: Pu Dai; Fei Yu; Bing Han; Yongyi Yuan; Qi Li; Guojian Wang; Xin Liu; Jia He; Deliang Huang; Dongyang Kang; Xin Zhang; Huijun Yuan; Eric Schmitt; Dongyi Han; Lee-Jun C Wong
The prevalence of the 235delC GJB2 mutation in a Chinese deaf population.
Genetics in medicine : official journal of the American College of Medical Genetics 2007;9(5):283-9.
2007: David Dimmock; Keiko Kobayashi; Mikio Iijima; Ayako Tabata; Lee-Jun C Wong; Takeyori Saheki; Brendan Lee; Fernando Scaglia
Citrin deficiency: a novel cause of failure to thrive that responds to a high-protein, low-carbohydrate diet.
Pediatrics 2007;119(3):e773-7.
2007: Lee-Jun C Wong
Diagnostic challenges of mitochondrial DNA disorders.
Mitochondrion 2007;7(1-2):45-52.
2006: Annette Feigenbaum; Ren-Kui Bai; Emily S Doherty; Haeyoung Kwon; Duanjun Tan; Avril Sloane; Ernest Cutz; Brian H Robinson; Lee-Jun C Wong
Novel mitochondrial DNA mutations associated with myopathy, cardiomyopathy, renal failure, and deafness.
American journal of medical genetics. Part A 2006;140(20):2216-22.
2006: Fernando Scaglia; Chang-Hung Hsu; Haeyoung Kwon; Ren-Kui Bai; Cherng-Lih Perng; Hua-Mei Chang; Pu Dai; E O'Brian Smith; David A H Whiteman; Annette Feigenbaum; Andrea Gropman; Lee-Jun C Wong
Molecular bases of hearing loss in multi-systemic mitochondrial cytopathy.
Genetics in medicine : official journal of the American College of Medical Genetics 2006;8(10):641-52.
2006: Michael J Gambello; Ren-Kui Bai; Tian-Jian Chen; Mazen Dimachkie; Lee-Jun C Wong
Exercise intolerance associated with a novel 8300T > C mutation in mitochondrial transfer RNAlys.
Muscle & nerve 2006;34(4):437-43.
2006: Lee-Jun C Wong; D Yim; Ren-Kui Bai; H Kwon; M M Vacek; J Zane; C L Hoppel; D S Kerr
A novel mutation in the mitochondrial tRNA(Ser(AGY)) gene associated with mitochondrial myopathy, encephalopathy, and complex I deficiency.
Journal of medical genetics 2006;43(9):e46.
2006: Gregory M Enns; Ren-Kui Bai; Anita E Beck; Lee-Jun C Wong
Molecular-clinical correlations in a family with variable tissue mitochondrial DNA T8993G mutant load.
Molecular genetics and metabolism 2006;88(4):364-71.
2006: Lee-Jun C Wong; Bryan R Cobb; Tian-Jian Chen
Molecular analysis of mitochondrial DNA point mutations by polymerase chain reaction.
Methods in molecular biology (Clifton, N.J.) 2006;336():135-43.
2006: Lee-Jun C Wong; Ren-Kui Bai
Real-time quantitative polymerase chain reaction analysis of mitochondrial DNA point mutation.
Methods in molecular biology (Clifton, N.J.) 2006;335():187-200.
2006: Lee-Jun C Wong; Pu Dai; Jyh-Feng Lu; Mary Ann Lou; Robert Clarke; Viktor Nazarov
AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines.
BMC cancer 2006;6():111.
2006: Duan-Jun Tan; Julia Chang; Ling-Ling Liu; Ren-Kui Bai; Yu-Fen Wang; Kun-Tu Yeh; Lee-Jun C Wong
Significance of somatic mutations and content alteration of mitochondrial DNA in esophageal cancer.
BMC cancer 2006;6():93.
2005: Ren-Kui Bai; Lee-Jun C Wong
Simultaneous detection and quantification of mitochondrial DNA deletion(s), depletion, and over-replication in patients with mitochondrial disease.
The Journal of molecular diagnostics : JMD 2005;7(5):613-22.
2005: Chien-Chih Wu; Özgül M Alper; Jyh-Feng Lu; Song-Ping Wang; Li Guo; Han-Sun Chiang; Lee-Jun C Wong
Mutation spectrum of the CFTR gene in Taiwanese patients with congenital bilateral absence of the vas deferens.
Human reproduction (Oxford, England) 2005;20(9):2470-5.
2005: Fernando Scaglia; Lee-Jun C Wong; Georgirene D Vladutiu; Jill V Hunter
Predominant cerebellar volume loss as a neuroradiologic feature of pediatric respiratory chain defects.
AJNR. American journal of neuroradiology 2005;26(7):1675-80.
2005: Grace A McComsey; Ren-Kui Bai; Jen-Fue Maa; Daniel Seekins; Lee-Jun C Wong
Extensive investigations of mitochondrial DNA genome in treated HIV-infected subjects: beyond mitochondrial DNA depletion.
Journal of acquired immune deficiency syndromes (1999) 2005;39(2):181-8.
2005: Chang-Hung Hsu; Haeyoung Kwon; Cherng-Lih Perng; Ren-Kui Bai; Pu Dai; Lee-Jun C Wong
Hearing loss in mitochondrial disorders.
Annals of the New York Academy of Sciences 2005;1042():36-47.
2005: Lee-Jun C Wong; Richard G Boles
Mitochondrial DNA analysis in clinical laboratory diagnostics.
Clinica chimica acta; international journal of clinical chemistry 2005;354(1-2):1-20.
2005: Lee-Jun C Wong; Y-H Lin; P Suwannarat; C-H Hsu; H-Y Kwon; S Mackowiak
Mitochondrial DNA mutations in a patient with sex reversal and clinical features consistent with Fraser syndrome.
Clinical genetics 2005;67(3):252-7.
2005: Lee-Jun C Wong
Molecular genetics of common mitochondrial DNA disorders.
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2005;37(1):26-31.
2004: Lee-Jun C Wong; Özgül M Alper; Evelyn Hsu; Marlyn S Woo; Monique F Margetis
The necessity of complete CFTR mutational analysis of an infertile couple before in vitro fertilization.
Fertility and sterility 2004;82(4):947-9.
2004: Fernando Scaglia; Jeffrey A Towbin; William J Craigen; John W Belmont; E O'Brian Smith; Steven R Neish; Stephanie M Ware; Jill V Hunter; Susan D Fernbach; Georgirene D Vladutiu; Lee-Jun C Wong; Hannes Vogel
Clinical spectrum, morbidity, and mortality in 113 pediatric patients with mitochondrial disease.
Pediatrics 2004;114(4):925-31.
2004: Özgül M Alper; Lee-Jun C Wong; Suzanne Young; Michelle Pearl; Steve Graham; John Sherwin; Eliezer Nussbaum; Dennis Nielson; Arnold Platzker; Zoe Davies; Allan Lieberthal; Terry Chin; Greg Shay; Karen Hardy; Martin Kharrazi
Identification of novel and rare mutations in California Hispanic and African American cystic fibrosis patients.
Human mutation 2004;24(4):353.
2004: Sara Shanske; Lee-Jun C Wong
Molecular analysis for mitochondrial DNA disorders.
Mitochondrion 2004;4(5-6):403-15.
2004: Andreas Kurtz; Maria Lueth; Lan Kluwe; Tingguo Zhang; Rosemary Foster; Victor-Felix Mautner; Melanie Hartmann; Duan-Jun Tan; Robert L Martuza; Reinhard E Friedrich; Pablo Hernáiz Driever; Lee-Jun C Wong
Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors.
Molecular cancer research : MCR 2004;2(8):433-41.
2004: Lee-Jun C Wong; Tian-Jian Chen; Duan-Jun Tan
Detection of mitochondrial DNA mutations using temporal temperature gradient gel electrophoresis.
Electrophoresis 2004;25(15):2602-10.
2004: Lee-Jun C Wong; Özgül M Alper
Detection of CFTR mutations using temporal temperature gradient gel electrophoresis.
Electrophoresis 2004;25(15):2593-601.
2004: Ling-Ling Liu; Duan-Jun Tan; Shi-Wen Wang; Lee-Jun C Wong
[Evaluation of inheritable character in essential hypertension through reconstruction of neighbor-joining tree].
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji 2004;26(4):441-5.
2004: Lee-Jun C Wong; Christopher Wladyka; Rebecca Mardach-Verdon
A mitochondrial DNA mutation in a patient with an extensive family history of Duchenne muscular dystrophy.
Muscle & nerve 2004;30(1):118-22.
2004: Ren-Kui Bai; Lee-Jun C Wong
Detection and quantification of heteroplasmic mutant mitochondrial DNA by real-time amplification refractory mutation system quantitative PCR analysis: a single-step approach.
Clinical chemistry 2004;50(6):996-1001.
2004: Lee-Jun C Wong; Duan-Jun Tan; Ren-Kui Bai; Kun-Tu Yeh; Julia Chang
Molecular alterations in mitochondrial DNA of hepatocellular carcinomas: is there a correlation with clinicopathological profile?
Journal of medical genetics 2004;41(5):e65.
2004: Lingling Liu; Duanjun Tan; Lee-Jun C Wong
[Somatic mutation detection in complete mitochondrial DNA of lung cancer patients].
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2004;7(2):125-9.
2004: Duan-Jun Tan; Julia Chang; Woan-Ling Chen; Lesley J Agress; Kun-Tu Yeh; Baotyan Wang; Lee-Jun C Wong
Somatic mitochondrial DNA mutations in oral cancer of betel quid chewers.
Annals of the New York Academy of Sciences 2004;1011():310-6.
2004: Ren-Kui Bai; Cherng-Lih Perng; Chang-Hung Hsu; Lee-Jun C Wong
Quantitative PCR analysis of mitochondrial DNA content in patients with mitochondrial disease.
Annals of the New York Academy of Sciences 2004;1011():304-9.
2004: Haeyoung Kwon; Duan-Jun Tan; Ren-Kui Bai; Lee-Jun C Wong
Enhanced detection of deleterious mutations by TTGE analysis of mother and child's DNA side by side.
Annals of the New York Academy of Sciences 2004;1011():299-303.
2004: Lee-Jun C Wong
Comprehensive molecular diagnosis of mitochondrial disorders: qualitative and quantitative approach.
Annals of the New York Academy of Sciences 2004;1011():246-58.
2004: Kinga Szigeti; Lee-Jun C Wong; Cherng-Lih Perng; Gulam Mustafa Saifi; Karen W Eldin; Adekunle M Adesina; Darrell L Cass; M Hirano; James R Lupski; Fernando Scaglia
MNGIE with lack of skeletal muscle involvement and a novel TP splice site mutation.
Journal of medical genetics 2004;41(2):125-9.
2004: Said Baidas; Tian-Jian Chen; Valentin Kolev; Lee-Jun C Wong; Joel Imholte; Naigeng Qin; Jeanne M Meck
Constitutional trisomy 8 mosaicism due to meiosis II non-disjunction in a phenotypically normal woman with hematologic abnormalities.
American journal of medical genetics. Part A 2004;124A(4):383-7.
2004: Andrea Gropman; Tian-Jian Chen; Cherng-Lih Perng; Donna Krasnewich; Edith Chernoff; Cynthia J Tifft; Lee-Jun C Wong
Variable clinical manifestation of homoplasmic G14459A mitochondrial DNA mutation.
American journal of medical genetics. Part A 2004;124A(4):377-82.
2004: scott williams; Marylyn Ritchie; John A Phillips; Elliot Dawson; Melissa Prince; Elvira Dzhura; Alecia Willis; Amma Semenya; Marshall Summar; Bill C White; Jonathan H Addy; John Kpodonu; Lee-Jun C Wong; Robin A Felder; Pedro Jose; Jason Moore
Multilocus analysis of hypertension: a hierarchical approach.
Human heredity 2004;57(1):28-38.
2003: P Dai; Lee-Jun C Wong
Somatic instability of the DNA sequences encoding the polymorphic polyglutamine tract of the AIB1 gene.
Journal of medical genetics 2003;40(12):885-90.
2003: Fernando Scaglia; Hannes Vogel; Edith P Hawkins; Georgirene D Vladutiu; Ling-Ling Liu; Lee-Jun C Wong
Novel homoplasmic mutation in the mitochondrial tRNATyr gene associated with atypical mitochondrial cytopathy presenting with focal segmental glomerulosclerosis.
American journal of medical genetics. Part A 2003;123A(2):172-8.
2003: Lee-Jun C Wong; Cherng-Lih Perng; Chang-Hung Hsu; Ren-Kui Bai; Susan Schelley; G D Vladutiu; H Vogel; Gregory M Enns
Compensatory amplification of mtDNA in a patient with a novel deletion/duplication and high mutant load.
Journal of medical genetics 2003;40(11):e125.
2003: Lee-Jun C Wong; Maria Lueth; Xiao-Nan Li; Ching C Lau; Hannes Vogel
Detection of mitochondrial DNA mutations in the tumor and cerebrospinal fluid of medulloblastoma patients.
Cancer research 2003;63(14):3866-71.
2003: Lee-Jun C Wong; Özgül M Alper; Bao-Tyan Wang; Mei-Hui Lee; Shin-Yu Lo
Two novel null mutations in a Taiwanese cystic fibrosis patient and a survey of East Asian CFTR mutations.
American journal of medical genetics. Part A 2003;120A(2):296-8.
2003: Özgül M Alper; Lee-Jun C Wong; Galen Hostetter; James Cook; Beverly Tenenholz; Evelyn Hsu; Marlyn S Woo
1154insTC is not a rare CFTR mutation.
American journal of medical genetics. Part A 2003;120A(2):294-5.
2003: Duan-Jun Tan; Julia Chang; Woan-Ling Chen; Lesley J Agress; Kun-Tu Yeh; Baotyan Wang; Lee-Jun C Wong
Novel heteroplasmic frameshift and missense somatic mitochondrial DNA mutations in oral cancer of betel quid chewers.
Genes, chromosomes & cancer 2003;37(2):186-94.
2003: Özgül M Alper; San-Ging Shu; Mei-Hui Lee; Bao-Tyan Wang; Shin-Yu Lo; Keh-Liang Lin; Ya-Lan Chiu; Lee-Jun C Wong
Detection of novel CFTR mutations in Taiwanese cystic fibrosis patients.
Journal of the Formosan Medical Association = Taiwan yi zhi 2003;102(5):287-91.
2002: Fernando Scaglia; Angela E Scheuerle; Jeffrey A Towbin; Dawna L Armstrong; Lawrence Sweetman; Lee-Jun C Wong
Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism.
BMC pediatrics 2002;2():12.
2002: Diane K Hancock; Frederick P Schwarz; Fenhong Song; Lee-Jun C Wong; Barbara C Levin
Design and use of a peptide nucleic acid for detection of the heteroplasmic low-frequency mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) mutation in human mitochondrial DNA.
Clinical chemistry 2002;48(12):2155-63.
2002: Lee-Jun C Wong; Minna Liang; Haeyoung Kwon; Ren-Kui Bai; Özgül M Alper; Andrea Gropman
A cystic fibrosis patient with two novel mutations in mitochondrial DNA: mild disease led to delayed diagnosis of both disorders.
American journal of medical genetics 2002;113(1):59-64.
2002: Lee-Jun C Wong; Minna Liang; Haeyoung Kwon; John Park; Ren-Kui Bai; Duan-Jun Tan
Comprehensive scanning of the entire mitochondrial genome for mutations.
Clinical chemistry 2002;48(11):1901-12.
2002: Robin A Felder; Hironobu Sanada; Jing Xu; Peiying Yu; Zheng Wang; Hidetsuna Watanabe; Laureano Asico; Wei Wang; Shaopeng Zheng; Ikuyo Yamaguchi; scott williams; John L Gainer; Nancy J Brown; Debra J Hazen-Martin; Lee-Jun C Wong; Jean E Robillard; Robert M Carey; Gilbert M Eisner; Pedro Jose
G protein-coupled receptor kinase 4 gene variants in human essential hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3872-7.
2002: Grace A McComsey; Duan-Jun Tan; Michael Lederman; Elizabeth Wilson; Lee-Jun C Wong
Analysis of the mitochondrial DNA genome in the peripheral blood leukocytes of HIV-infected patients with or without lipoatrophy.
AIDS (London, England) 2002;16(4):513-8.
2002: Lee-Jun C Wong; Hansie Wong; Aiyi Liu
Intergenerational transmission of pathogenic heteroplasmic mitochondrial DNA.
Genetics in medicine : official journal of the American College of Medical Genetics 2002;4(2):78-83.
2002: Duan-Jun Tan; Ren-Kui Bai; Lee-Jun C Wong
Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer.
Cancer research 2002;62(4):972-6.
2002: Lee-Jun C Wong; Jianjun Wang; Ying-Hua Zhang; Evelyn Hsu; Ruth A Heim; Charles Michael Bowman; Marlyn S Woo
Improved detection of CFTR mutations in southern California Hispanic CF patients.
Human mutation 2002;19(1):79.
2001: Lee-Jun C Wong
Recognition of mitochondrial DNA deletion syndrome with non-neuromuscular multisystemic manifestation.
Genetics in medicine : official journal of the American College of Medical Genetics 2001;3(6):399-404.
2001: Lee-Jun C Wong; Jianjun Wang; Y H Zhang; Evelyn Hsu; R A Heim; Charles Michael Bowman; Marlyn S Woo
Improved detection of CFTR mutations in Southern California Hispanic CF patients.
Human mutation 2001;18(4):296-307.
2001: Lee-Jun C Wong; Jianjun Wang; Charles Michael Bowman
Two novel frame shift mutations of CFTR causing null alleles in a patient with a severe course of CF.
American journal of medical genetics 2001;102(4):389-90.
2001: Lee-Jun C Wong; Tian-Jian Chen; Pu Dai; L Bird; M Muenke
Novel SNP at the common primer site of exon IIIa of FGFR2 gene causes error in molecular diagnosis of craniosynostosis syndrome.
American journal of medical genetics 2001;102(3):282-5.
2001: Lee-Jun C Wong; Pu Dai; D Tan; MH Lipson; Arthur W Grix; M Sifry-Platt; Andrea Gropman; Tian-Jian Chen
Severe lactic acidosis caused by a novel frame-shift mutation in mitochondrial-encoded cytochrome c oxidase subunit II.
American journal of medical genetics 2001;102(1):95-9.
2001: Lee-Jun C Wong; W L Hwu; Pu Dai; Tian-Jian Chen
Molecular genetics of glycogen-storage disease type 1a in Chinese patients of Taiwan.
Molecular genetics and metabolism 2001;72(2):175-80.
2000: Lee-Jun C Wong; Jianjun Wang; M Woo; Evelyn Hsu; Charles Michael Bowman
A novel mutation detected by temporal temperature gradient gel electrophoresis led to the confirmative prenatal diagnosis of a Hispanic CF family.
Prenatal diagnosis 2000;20(10):807-10.
2000: Jianjun Wang; Charles Michael Bowman; Lee-Jun C Wong
A novel CFTR frame-shift mutation, 935delA, in two Hispanic cystic fibrosis patients.
Molecular genetics and metabolism 2000;70(4):316-21.
2000: scott williams; Jonathan H Addy; John A Phillips; M Dai; J Kpodonu; J Afful; Harold Oran Jackson; K Joseph; F Eason; M M Murray; P Epperson; Adwoa Aduonum; Lee-Jun C Wong; Pedro Jose; Robin A Felder
Combinations of variations in multiple genes are associated with hypertension.
Hypertension 2000;36(1):2-6.
1999: T J Chen; R G Boles; Lee-Jun C Wong
Detection of mitochondrial DNA mutations by temporal temperature gradient gel electrophoresis.
Clinical chemistry 1999;45(8 Pt 1):1162-7.
1998: Lee-Jun C Wong; Minna Liang; W L Hwu; C W Lam
Linkage disequilibrium and linkage analysis of the glucose-6-phosphatase gene.
Human genetics 1998;103(2):199-203.
1998: Minna Liang; K K Wertz; Charles Michael Bowman; E Hsu; B Shapiro; Lee-Jun C Wong
3849 + 10 kb C --> T splicing mutation in Hispanic CF patients.
Molecular genetics and metabolism 1998;64(3):213-6.
1998: Minna Liang; D R Johnson; Lee-Jun C Wong
Preparation and validation of PCR-generated positive controls for diagnostic dot blotting.
Clinical chemistry 1998;44(7):1578-9.
1998: Minna Liang; Lee-Jun C Wong
Yield of mtDNA mutation analysis in 2,000 patients.
American journal of medical genetics 1998;77(5):395-400.
1998: Minna Liang; Lee-Jun C Wong; D Klein; B Shapiro; Charles Michael Bowman; E Hsu; L J Wong
Cystic fibrosis in a Puerto Rican female homozygous for the R1066C mutation.
Journal of medical genetics 1998;35(1):84-5.
1997: T J Harrison; R G Boles; D R Johnson; C LeBlond; Lee-Jun C Wong
Macular pattern retinal dystrophy, adult-onset diabetes, and deafness: a family study of A3243G mitochondrial heteroplasmy.
American journal of ophthalmology 1997;124(2):217-21.
1996: Lee-Jun C Wong
Prenatal diagnosis of glycogen storage disease type 1a by direct mutation detection.
Prenatal diagnosis 1996;16(2):105-8.
1992: S S Wong; Lee-Jun C Wong
Chemical crosslinking and the stabilization of proteins and enzymes.
Enzyme and microbial technology 1992;14(11):866-74.