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Henry Brem

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
de Almeida João Paulo C; Petteys Rory J; Sciubba Daniel M; Gallia Gary L; Brem Henry
Regression of intracranial meningioma following intratumoral hemorrhage.
Slager Joram; Tyler Betty; Shikanov Ariella; Domb Abraham J; Shogen Kuslima; Sidransky David; Brem Henry
Local controlled delivery of anti-neoplastic RNAse to the brain.
McGirt Matthew J; Than Khoi D; Weingart Jon D; Chaichana Kaisorn L; Attenello Frank J; Olivi Alessandro; Laterra John; Kleinberg Lawrence R; Grossman Stuart A; Brem Henry; Quiñones-Hinojosa Alfredo
Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme.

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All Publications

2009: de Almeida João Paulo C; Petteys Rory J; Sciubba Daniel M; Gallia Gary L; Brem Henry
Regression of intracranial meningioma following intratumoral hemorrhage.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2009;16(9):1246-9.
2009: Slager Joram; Tyler Betty; Shikanov Ariella; Domb Abraham J; Shogen Kuslima; Sidransky David; Brem Henry
Local controlled delivery of anti-neoplastic RNAse to the brain.
Pharmaceutical research 2009;26(8):1838-46.
2009: McGirt Matthew J; Than Khoi D; Weingart Jon D; Chaichana Kaisorn L; Attenello Frank J; Olivi Alessandro; Laterra John; Kleinberg Lawrence R; Grossman Stuart A; Brem Henry; Quiñones-Hinojosa Alfredo
Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme.
Journal of neurosurgery 2009;110(3):583-8.
2009: Gathinji Muraya; McGirt Matthew J; Attenello Frank J; Chaichana Kaisorn L; Than Khoi; Olivi Alessandro; Weingart Jon D; Brem Henry; Quinones-Hinojosa Alfredo
Association of preoperative depression and survival after resection of malignant brain astrocytoma.
Surgical neurology 2009;71(3):299-303, discussion 303.
2009: Gallia Gary L; Tyler Betty M; Hann Christine L; Siu I-Mei; Giranda Vincent L; Vescovi Angelo L; Brem Henry; Riggins Gregory J
Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells.
Molecular cancer therapeutics 2009;8(2):386-93.
2009: McGirt Matthew J; Chaichana Kaisorn L; Gathinji Muraya; Attenello Frank J; Than Khoi; Olivi Alessandro; Weingart Jon D; Brem Henry; Quiñones-Hinojosa Alf Redo
Independent association of extent of resection with survival in patients with malignant brain astrocytoma.
Journal of neurosurgery 2009;110(1):156-62.
2008: McGirt Matthew J; Chaichana Kaisorn L; Attenello Frank J; Weingart Jon D; Than Khoi; Burger Peter C; Olivi Alessandro; Brem Henry; Quinoñes-Hinojosa Alfredo
Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas.
Neurosurgery 2008;63(4):700-7; author reply 707-8.
2008: Attenello Frank J; Mukherjee Debraj; Datoo Ghazala; McGirt Matthew J; Bohan Eileen; Weingart Jon D; Olivi Alessandro; Quinones-Hinojosa Alfredo; Brem Henry
Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience.
Annals of surgical oncology 2008;15(10):2887-93.
2008: Brem Steven S; Bierman Philip J; Black Peter; Brem Henry; Chamberlain Marc C; Chiocca Ennio A; DeAngelis Lisa M; Fenstermaker Robert A; Friedman Allan; Gilbert Mark R; Glass Jon; Grossman Stuart A; Heimberger Amy B; Junck Larry; Linette Gerald P; Loeffler Jay J; Maor Moshe H; Moots Paul; Mrugala Maciej; Nabors Louis Burt; Newton Herbert B; Olivi Alessandro; Portnow Jana; Prados Michael; Raizer Jeffrey J; Shrieve Dennis C; Sills Allen K
Central nervous system cancers.
Journal of the National Comprehensive Cancer Network : JNCCN 2008;6(5):456-504.
2008: Sonabend Adam M; Velicu Simona; Ulasov Ilya V; Han Yu; Tyler Betty; Brem Henry; Matar Majed M; Fewell Jason G; Anwer Khursheed; Lesniak Maciej S
A safety and efficacy study of local delivery of interleukin-12 transgene by PPC polymer in a model of experimental glioma.
Anti-cancer drugs 2008;19(2):133-42.
2007: Kim Grace Y; Tyler Betty M; Tupper Malinda M; Karp Jeffrey M; Langer Robert S; Brem Henry; Cima Michael J
Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model.
Journal of controlled release : official journal of the Controlled Release Society 2007;123(2):172-8.
2007: Brem Sarah; Tyler Betty; Li Khan; Pradilla Gustavo; Legnani Federico; Caplan Justin; Brem Henry
Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model.
Cancer chemotherapy and pharmacology 2007;60(5):643-50.
2007: Marupudi Neena I; Han James E; Li Khan W; Renard Violette M; Tyler Betty M; Brem Henry
Paclitaxel: a review of adverse toxicities and novel delivery strategies.
Expert opinion on drug safety 2007;6(5):609-21.
2007: Kominsky Scott L; Tyler Betty; Sosnowski Jeffrey; Brady Kelly; Doucet Michele; Nell Delissa; Smedley James G; McClane Bruce; Brem Henry; Sukumar Saraswati
Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis.
Cancer research 2007;67(17):7977-82.
2007: Baird Clinton J; Hdeib Alia; Suk Ian; Francis Howard W; Holliday Michael J; Tamargo Rafael J; Brem Henry; Long Donlin M
Reduction of cerebrospinal fluid rhinorrhea after vestibular schwannoma surgery by reconstruction of the drilled porus acusticus with hydroxyapatite bone cement.
Journal of neurosurgery 2007;107(2):347-51.
2007: Chaichana Kaisorn L; Capilla-Gonzalez Vivian; Gonzalez-Perez Oscar; Pradilla Gustavo; Han James; Olivi Alessandro; Brem Henry; Garcia-Verdugo Jose Manuel; Quiñones-Hinojosa Alfredo
Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases.
Journal of neuroscience methods 2007;164(2):261-70.
2007: Lawson H Christopher; Sampath Prakash; Bohan Eileen; Park Michael C; Hussain Namath; Olivi Alessandro; Weingart Jon; Kleinberg Lawrence; Brem Henry
Interstitial chemotherapy for malignant gliomas: the Johns Hopkins experience.
Journal of neuro-oncology 2007;83(1):61-70.
2007: Michaels Robert K; Makary Martin A; Dahab Yasser; Frassica Frank J; Heitmiller Eugenie; Rowen Lisa C; Crotreau Richard; Brem Henry; Pronovost Peter J
Achieving the National Quality Forum's "Never Events": prevention of wrong site, wrong procedure, and wrong patient operations.
Annals of surgery 2007;245(4):526-32.
2007: Bookland Markus J; Bagley Carlos A; Schwarz Jacob; Burger Peter C; Brem Henry
Intracavernous trigeminal ganglion amyloidoma: case report.
Neurosurgery 2007;60(3):E574; discussion E574.
2006: Piccirillo S G M; Reynolds B A; Zanetti N; Lamorte G; Binda E; Broggi G; Brem H; Olivi A; Dimeco F; Vescovi A L
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.
Nature 2006;444(7120):761-5.
2006: Sampath Prakash; Rhines Laurence D; DiMeco Francesco; Tyler Betty M; Park Michael C; Brem Henry
Interstitial docetaxel (taxotere), carmustine and combined interstitial therapy: a novel treatment for experimental malignant glioma.
Journal of neuro-oncology 2006;80(1):9-17.
2006: Fruehauf John P; Brem Henry; Brem Steven; Sloan Andrew; Barger Geoffrey; Huang Weidong; Parker Ricardo
In vitro drug response and molecular markers associated with drug resistance in malignant gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4523-32.
2006: Caplan Justin; Pradilla Gustavo; Hdeib Alia; Tyler Betty M; Legnani Federico G; Bagley Carlos A; Brem Henry; Jallo George
A novel model of intramedullary spinal cord tumors in rats: functional progression and histopathological characterization.
Neurosurgery 2006;59(1):193-200; discussion 193-200.
2006: Legnani Federico G; Pradilla Gustavo; Thai Quoc-Anh; Fiorindi Alessandro; Recinos Pablo F; Tyler Betty M; Gaini Sergio M; DiMeco Francesco; Brem Henry; Olivi Alessandro
Lactacystin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.
Journal of neuro-oncology 2006;77(3):225-32.
2006: Pradilla Gustavo; Wang Paul P; Gabikian Patrik; Li Khan; Magee Carolyn A; Walter Kevin A; Brem Henry
Local intracerebral administration of Paclitaxel with the paclimer delivery system: toxicity study in a canine model.
Journal of neuro-oncology 2006;76(2):131-8.
2005: Lesniak Maciej S; Upadhyay Urvashi; Goodwin Rory; Tyler Betty; Brem Henry
Local delivery of doxorubicin for the treatment of malignant brain tumors in rats.
Anticancer research 2005;25(6B):3825-31.
2005: Pradilla Gustavo; Legnani Federico G; Petrangolini Giovanna; Francescato Pierangelo; Chillemi Francesco; Tyler Betty M; Gaini Sergio M; Brem Henry; Olivi Alessandro; DiMeco Francesco
Local delivery of a synthetic endostatin fragment for the treatment of experimental gliomas.
Neurosurgery 2005;57(5):1032-40; discussion 1032-40.
2005: Quinn Jennifer A; Desjardins Annick; Weingart Jon; Brem Henry; Dolan M Eileen; Delaney Shannon M; Vredenburgh James; Rich Jeremy; Friedman Allan H; Reardon David A; Sampson John H; Pegg Anthony E; Moschel Robert C; Birch Robert; McLendon Roger E; Provenzale James M; Gururangan Sridharan; Dancey Janet E; Maxwell Jill; Tourt-Uhlig Sandra; Herndon James E; Bigner Darell D; Friedman Henry S
Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(28):7178-87.
2005: Gallia Gary L; Brem Steven; Brem Henry
Local treatment of malignant brain tumors using implantable chemotherapeutic polymers.
Journal of the National Comprehensive Cancer Network : JNCCN 2005;3(5):721-8.
2005: Brem Steven S; Bierman Philip J; Black Peter; Blumenthal Deborah T; Brem Henry; Chamberlain Marc C; Chiocca Ennio A; DeAngelis Lisa M; Fenstermaker Robert A; Fine Howard A; Friedman Allan; Glass Jon; Grossman Stuart A; Heimberger Amy B; Junck Larry; Levin Victor; Loeffler Jay J; Maor Moshe H; Narayana Ashwatha; Newton Herbert B; Olivi Alessandro; Portnow Jana; Prados Michael; Raizer Jeffrey J; Rosenfeld Steven S; Shrieve Dennis C; Sills Allen K; Spence Alexander M; Vrionis Frank D;
Central nervous system cancers: Clinical Practice Guidelines in Oncology.
Journal of the National Comprehensive Cancer Network : JNCCN 2005;3(5):644-90.
2005: Hsu Wesley; Lesniak Maciej S; Tyler Betty; Brem Henry
Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma.
Journal of neuro-oncology 2005;74(2):135-40.
2005: Mavinkurve Gaurav; Pradilla Gustavo; Legnani Federico G; Tyler Betty M; Bagley Carlos A; Brem Henry; Jallo George
A novel intramedullary spinal cord tumor model: functional, radiological, and histopathological characterization.
Journal of neurosurgery. Spine 2005;3(2):142-8.
2005: Li Yawen; Ho Duc Hong Linh; Tyler Betty; Williams Tiffany; Tupper Malinda; Langer Robert; Brem Henry; Cima Michael J
In vivo delivery of BCNU from a MEMS device to a tumor model.
Journal of controlled release : official journal of the Controlled Release Society 2005;106(1-2):138-45.
2005: Raza Shaan M; Pradilla Gustavo; Legnani Federico G; Thai Quoc Anh; Olivi Alessandro; Weingart Jon D; Brem Henry
Local delivery of antineoplastic agents by controlled-release polymers for the treatment of malignant brain tumours.
Expert opinion on biological therapy 2005;5(4):477-94.
2005: Mantha Ajay; Legnani Federico G; Bagley Carlos A; Gallia Gary L; Garonzik Ira; Pradilla Gustavo; Amundson Eric; Tyler Betty M; Brem Henry; Gokaslan Ziya L
A novel rat model for the study of intraosseous metastatic spine cancer.
Journal of neurosurgery. Spine 2005;2(3):303-7.
2005: Koenig Marthew A; Geocadin Romergryko G; Kulesza Piotr; Olivi Alessandro; Brem Henry
Rhabdoid meningioma occurring in an unrelated resection cavity with leptomeningeal carcinomatosis. Case report.
Journal of neurosurgery 2005;102(2):371-5.
2005: Chang Susan M; Parney Ian F; Huang Wei; Anderson Frederick A; Asher Anthony L; Bernstein Mark; Lillehei Kevin O; Brem Henry; Berger Mitchel S; Laws Edward R;
Patterns of care for adults with newly diagnosed malignant glioma.
JAMA : the journal of the American Medical Association 2005;293(5):557-64.
2004: Li Yawen; Shawgo Rebecca S; Tyler Betty; Henderson Paul T; Vogel John S; Rosenberg Aron; Storm Phillip B; Langer Robert; Brem Henry; Cima Michael J
In vivo release from a drug delivery MEMS device.
Journal of controlled release : official journal of the Controlled Release Society 2004;100(2):211-9.
2004: Lesniak Maciej S; Gabikian Patrick; Tyler Betty M; Pardoll Drew M; Brem Henry
Dexamethasone mediated inhibition of local IL-2 immunotherapy is dose dependent in experimental brain tumors.
Journal of neuro-oncology 2004;70(1):23-8.
2004: Storm Phillip B; Renard Violette M; Moriarity John L; Tyler Betty; Wilentz Robb E; Brem Henry; Weingart Jon D
Systemic BCNU enhances the efficacy of local delivery of a topoisomerase I inhibitor against malignant glioma.
Cancer chemotherapy and pharmacology 2004;54(4):361-7.
2004: Lesniak Maciej S; Brem Henry
Targeted therapy for brain tumours.
Nature reviews. Drug discovery 2004;3(6):499-508.
2004: Basaria S; Westra W H; Brem H; Salvatori R
Metastatic renal cell carcinoma to the pituitary presenting with hyperprolactinemia.
Journal of endocrinological investigation 2004;27(5):471-4.
2004: Samdani Amer F; Kuchner Eric B; Rhines Laurence; Adamson David C; Lawson Christopher; Tyler Betty; Brem Henry; Dawson Valina L; Dawson Ted M
Astroglia induce cytotoxic effects on brain tumors via a nitric oxide-dependent pathway both in vitro and in vivo.
Neurosurgery 2004;54(5):1231-7; discussion 1237-8.
2004: Guerin Christopher; Olivi Alessandro; Weingart Jon D; Lawson H Christopher; Brem Henry
Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers.
Investigational new drugs 2004;22(1):27-37.
2004: Komotar Ricardo J; Burger Peter C; Carson Benjamin S; Brem Henry; Olivi Alessandro; Goldthwaite Patricia T; Tihan Tarik
Pilocytic and pilomyxoid hypothalamic/chiasmatic astrocytomas.
Neurosurgery 2004;54(1):72-9; discussion 79-80.
2004: Kleinberg Lawrence R; Weingart Jon; Burger Peter; Carson Katherine; Grossman Stuart A; Li Khan; Olivi Alessandro; Wharam Moody D; Brem Henry
Clinical course and pathologic findings after Gliadel and radiotherapy for newly diagnosed malignant glioma: implications for patient management.
Cancer investigation 2004;22(1):1-9.
2003: Moses Marsha A; Brem Henry; Langer Robert
Advancing the field of drug delivery: taking aim at cancer.
Cancer cell 2003;4(5):337-41.
2003: Richards Grayson Amy C; Choi Insung S; Tyler Betty M; Wang Paul P; Brem Henry; Cima Michael J; Langer Robert
Multi-pulse drug delivery from a resorbable polymeric microchip device.
Nature materials 2003;2(11):767-72.
2003: Pradilla Gustavo; Azzam Tony; Wang Paul P; Domb Abraham J; Brem Henry
Gene therapy for malignant brain tumors.
Expert review of neurotherapeutics 2003;3(5):685-701.
2003: Frazier James L; Wang Paul P; Case Daniel; Tyler Betty M; Pradilla Gustavo; Weingart Jon D; Brem Henry
Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma.
Journal of neuro-oncology 2003;64(3):203-9.
2003: Brem Henry; Amundson Eric
Preparing Hopkins medical students for a career in academic neurosurgery.
Surgery 2003;134(3):414-5.
2003: Laws Edward R; Parney Ian F; Huang Wei; Anderson Fred; Morris Angel M; Asher Anthony; Lillehei Kevin O; Bernstein Mark; Brem Henry; Sloan Andrew; Berger Mitchel S; Chang Susan;
Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project.
Journal of neurosurgery 2003;99(3):467-73.
2003: Li Khan W; Dang Wenbin; Tyler Betty M; Troiano Greg; Tihan Tarik; Brem Henry; Walter Kevin A
Polilactofate microspheres for Paclitaxel delivery to central nervous system malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(9):3441-7.
2003: Lesniak Maciej S; Tyler Betty M; Pardoll Drew M; Brem Henry
Gene therapy for experimental brain tumors using a xenogenic cell line engineered to secrete hIL-2.
Journal of neuro-oncology 2003;64(1-2):155-60.
2003: Chang Susan M; Parney Ian F; McDermott Michael; Barker Fred G; Schmidt Meic H; Huang Wei; Laws Edward R; Lillehei Kevin O; Bernstein Mark; Brem Henry; Sloan Andrew E; Berger Mitchel;
Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project.
Journal of neurosurgery 2003;98(6):1175-81.
2003: Hammoud Dima A; Belden Clifford J; Ho Amy C; Dal Pan Gerald J; Herskovits Edward H; Hilt Dana C; Brem Henry; Pomper Martin G
The surgical bed after BCNU polymer wafer placement for recurrent glioma: serial assessment on CT and MR imaging.
AJR. American journal of roentgenology 2003;180(5):1469-75.
2003: Long Donlin M; Gordon Toby; Bowman Helen; Etzel Anthony; Burleyson Gregg; Betchen Simone; Garonzik Ira M; Brem Henry
Outcome and cost of craniotomy performed to treat tumors in regional academic referral centers.
Neurosurgery 2003;52(5):1056-63; discussion 1063-5.
2003: Rhines Laurence D; Sampath Prakash; DiMeco Francesco; Lawson H Christopher; Tyler Betty M; Hanes Justin; Olivi Alessandro; Brem Henry
Local immunotherapy with interleukin-2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma.
Neurosurgery 2003;52(4):872-9; discussion 879-80.
2003: Sampath Prakash; Amundson Eric; Wall Monroe E; Tyler Betty M; Wani Mansukh C; Alderson Lloyd M; Colvin Michael; Brem Henry; Weingart Jon D
Camptothecin analogs in malignant gliomas: comparative analysis and characterization.
Journal of neurosurgery 2003;98(3):570-7.
2002: Lugassy Claire; Haroun Raymond I; Brem Henry; Tyler Betty M; Jones Robert V; Fernandez Patricia M; Patierno Steven R; Kleinman Hynda K; Barnhill Raymond L
Pericytic-like angiotropism of glioma and melanoma cells.
The American Journal of dermatopathology 2002;24(6):473-8.
2002: DiMeco Francesco; Li Khan W; Tyler Berry M; Wolf Ariel S; Brem Henry; Olivi Alessandro
Local delivery of mitoxantrone for the treatment of malignant brain tumors in rats.
Journal of neurosurgery 2002;97(5):1173-8.
2002: Wang Paul P; Frazier James; Brem Henry
Local drug delivery to the brain.
Advanced drug delivery reviews 2002;54(7):987-1013.
2002: Toung Thomas J K; Tyler Betty; Brem Henry; Traystman Richard J; Hurn Patricia D; Bhardwaj Anish
Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor.
Journal of neurosurgical anesthesiology 2002;14(3):187-93.
2002: Haroun Raymond I; Clatterbuck Richard E; Gibbons M Christopher; Burger Peter C; Parker Ricardo; Fruehauf John P; Brem Henry
Extreme drug resistance in primary brain tumors: in vitro analysis of 64 resection specimens.
Journal of neuro-oncology 2002;58(2):115-23.
2002: Liu Jeannette M; Garonzik Ira M; Eberhart Charles G; Sampath Prakash; Brem Henry
Ectopic recurrence of craniopharyngioma after an interhemispheric transcallosal approach: case report.
Neurosurgery 2002;50(3):639-44; discussion 644-5.
2002: Storm Phillip B; Moriarity John L; Tyler Betty; Burger Peter C; Brem Henry; Weingart Jon
Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy.
Journal of neuro-oncology 2002;56(3):209-17.
2001: Reavey-Cantwell J F; Haroun R I; Zahurak M; Clatterbuck R E; Parker R J; Mehta R; Fruehauf J P; Brem H
The prognostic value of tumor markers in patients with glioblastoma multiforme: analysis of 32 patients and review of the literature.
Journal of neuro-oncology 2001;55(3):195-204.
2001: Freitag S K; Miller N R; Brem H
Recurrent ectopic craniopharyngioma.
British journal of neurosurgery 2001;15(6):511-3.
2001: Kaminski J M; Movsas B; King E; Yang C; Kronz J D; Alli P M; Williams J; Brem H
Metastatic meningioma to the lung with multiple pleural metastases.
American journal of clinical oncology 2001;24(6):579-82.
2001: Rothstein J D; Brem H
Excitotoxic destruction facilitates brain tumor growth.
Nature medicine 2001;7(9):994-5.
2001: Hanes J; Sills A; Zhao Z; Suh K W; Tyler B; DiMeco F; Brat D J; Choti M A; Leong K W; Pardoll D M; Brem H
Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors.
Pharmaceutical research 2001;18(7):899-906.
2001: Brem H; Gabikian P
Biodegradable polymer implants to treat brain tumors.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):63-7.
2001: White M C; Burke M D; Peleg S; Brem H; Posner G H
Conformationally restricted hybrid analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): design, synthesis, and biological evaluation.
Bioorganic & medicinal chemistry 2001;9(7):1691-9.
2001: Lesniak M S; Langer R; Brem H
Drug delivery to tumors of the central nervous system.
Current neurology and neuroscience reports 2001;1(3):210-6.
2001: Sipos E P; Witham T F; Ratan R; Burger P C; Baraban J; Li K W; Piantadosi S; Brem H
L-buthionine sulfoximine potentiates the antitumor effect of 4-hydroperoxycyclophosphamide when administered locally in a rat glioma model.
Neurosurgery 2001;48(2):392-400.
2001: Conway J E; Chou D; Clatterbuck R E; Brem H; Long D M; Rigamonti D
Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease.
Neurosurgery 2001;48(1):55-62; discussion 62-3.
2000: Rhines L D; Sampath P; Dolan M E; Tyler B M; Brem H; Weingart J
O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
Cancer research 2000;60(22):6307-10.
2000: Sipos E P; Brem H
Local anti-angiogenic brain tumor therapies.
Journal of neuro-oncology 2000;50(1-2):181-8.
2000: Klink D F; Sampath P; Miller N R; Brem H; Long D M
Long-term visual outcome after nonradical microsurgery patients with parasellar and cavernous sinus meningiomas.
Neurosurgery 2000;47(1):24-31; discussion 31-2.
2000: Ewend M G; Thompson R C; Anderson R; Sills A K; Staveley-O'Carroll K; Tyler B M; Hanes J; Brat D; Thomas M; Jaffee E M; Pardoll D M; Brem H
Intracranial paracrine interleukin-2 therapy stimulates prolonged antitumor immunity that extends outside the central nervous system.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(4):438-48.
2000: Haroun R I; Brem H
Local drug delivery.
Current opinion in oncology 2000;12(3):187-93.
2000: Olivi A; DiMeco F; Bohan E; Brem H
Developing new methods for the treatment of malignant brain tumours: local delivery of anti-neoplastic agents using biodegradable polymers.
Forum (Genoa, Italy) 2000;10(2):152-65.
2000: DiMeco F; Rhines L D; Hanes J; Tyler B M; Brat D; Torchiana E; Guarnieri M; Colombo M P; Pardoll D M; Finocchiaro G; Brem H; Olivi A
Paracrine delivery of IL-12 against intracranial 9L gliosarcoma in rats.
Journal of neurosurgery 2000;92(3):419-27.
2000: Sampath P; Long D M; Brem H
The Hunterian Neurosurgical Laboratory: the first 100 years of neurosurgical research.
Neurosurgery 2000;46(1):184-94; discussion 194-5.
2000: Lesniak M S; Sampath P; DiMeco F; Viglione M P; Tyler B M; Pardoll D M; Brem H
Comparative analysis of paracrine immunotherapy in experimental brain tumors.
Neurosurgical focus 2000;9(6):e4.
1999: Suh K W; Piantadosi S; Yazdi H A; Pardoll D M; Brem H; Choti M A
Treatment of liver metastases from colon carcinoma with autologous tumor vaccine expressing granulocyte-macrophage colony-stimulating factor.
Journal of surgical oncology 1999;72(4):218-24.
1999: Posner G H; Wang Q; Han G; Lee J K; Crawford K; Zand S; Brem H; Peleg S; Dolan P; Kensler T W
Conceptually new sulfone analogues of the hormone 1alpha, 25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation.
Journal of medicinal chemistry 1999;42(18):3425-35.
1999: Brem H; Lawson H C
The development of new brain tumor therapy utilizing the local and sustained delivery of chemotherapeutic agents from biodegradable polymers.
Cancer 1999;86(2):197-9.
1999: Sampath P; Hanes J; DiMeco F; Tyler B M; Brat D; Pardoll D M; Brem H
Paracrine immunotherapy with interleukin-2 and local chemotherapy is synergistic in the treatment of experimental brain tumors.
Cancer research 1999;59(9):2107-14.
1998: Ewend M G; Sampath P; Williams J A; Tyler B M; Brem H
Local delivery of chemotherapy prolongs survival in experimental brain metastases from breast carcinoma.
Neurosurgery 1998;43(5):1185-93.
1998: Williams J A; Yuan X; Dillehay L E; Shastri V R; Brem H; Williams J R
Synthetic, implantable polymers for local delivery of IUdR to experimental human malignant glioma.
International journal of radiation oncology, biology, physics 1998;42(3):631-9.
1998: Chou D; Sampath P; Brem H
Hemorrhagic vestibular schwannoma: an unusual clinical entity. Case report.
Neurosurgical focus 1998;5(3):e9.
1998: Sampath P; Rhines L D; Holliday M J; Brem H; Long D M
Late-onset facial nerve degeneration after vestibular schwannoma surgery: incidence, putative mechanisms, and prevention.
Neurosurgical focus 1998;5(3):e6.
1998: Posner G H; Lee J K; Wang Q; Peleg S; Burke M; Brem H; Dolan P; Kensler T W
Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha, 25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation.
Journal of medicinal chemistry 1998;41(16):3008-14.
1998: Sills A K; Williams J I; Tyler B M; Epstein D S; Sipos E P; Davis J D; McLane M P; Pitchford S; Cheshire K; Gannon F H; Kinney W A; Chao T L; Donowitz M; Laterra J; Zasloff M; Brem H
Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature.
Cancer research 1998;58(13):2784-92.
1998: Wiranowska M; Ransohoff J; Weingart J D; Phelps C; Phuphanich S; Brem H
Interferon-containing controlled-release polymers for localized cerebral immunotherapy.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(6):377-85.
1998: Williams J; Enger C; Wharam M; Tsai D; Brem H
Stereotactic radiosurgery for brain metastases: comparison of lung carcinoma vs. non-lung tumors.
Journal of neuro-oncology 1998;37(1):79-85.
1998: Fung L K; Ewend M G; Sills A; Sipos E P; Thompson R; Watts M; Colvin O M; Brem H; Saltzman W M
Pharmacokinetics of interstitial delivery of carmustine, 4-hydroperoxycyclophosphamide, and paclitaxel from a biodegradable polymer implant in the monkey brain.
Cancer research 1998;58(4):672-84.
1998: Cardinale R M; Dillehay L E; Williams J A; Tabassi K; Brem H; Lee D J
Effect of interstitial and/or systemic delivery of tirapazamine on the radiosensitivity of human glioblastoma multiforme in nude mice.
Radiation oncology investigations 1998;6(2):63-70.
1997: Perry J R; DeAngelis L M; Schold S C; Burger P C; Brem H; Brown M T; Curran W J; Scott C B; Prados M D; Kaplan R; Cairncross J G
Challenges in the design and conduct of phase III brain tumor therapy trials.
Neurology 1997;49(4):912-7.
1997: Sampath P; Holliday M J; Brem H; Niparko J K; Long D M
Facial nerve injury in acoustic neuroma (vestibular schwannoma) surgery: etiology and prevention.
Journal of neurosurgery 1997;87(1):60-6.
1997: Williams J A; Dillehay L E; Tabassi K; Sipos E; Fahlman C; Brem H
Implantable biodegradable polymers for IUdR radiosensitization of experimental human malignant glioma.
Journal of neuro-oncology 1997;32(3):181-92.
1997: Kleinberg L; Slick T; Enger C; Grossman S; Brem H; Wharam M D
Short course radiotherapy is an appropriate option for most malignant glioma patients.
International journal of radiation oncology, biology, physics 1997;38(1):31-6.
1997: Sipos E P; Tyler B; Piantadosi S; Burger P C; Brem H
Optimizing interstitial delivery of BCNU from controlled release polymers for the treatment of brain tumors.
Cancer chemotherapy and pharmacology 1997;39(5):383-9.
1996: Thompson R C; Pardoll D M; Jaffee E M; Ewend M G; Thomas M C; Tyler B M; Brem H
Systemic and local paracrine cytokine therapies using transduced tumor cells are synergistic in treating intracranial tumors.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1996;19(6):405-13.
1996: Ewend M G; Carey L A; Brem H
Treatment of melanoma metastases in the brain.
Seminars in surgical oncology 1996;12(6):429-35.
1996: Ewend M G; Williams J A; Tabassi K; Tyler B M; Babel K M; Anderson R C; Pinn M L; Brat D J; Brem H
Local delivery of chemotherapy and concurrent external beam radiotherapy prolongs survival in metastatic brain tumor models.
Cancer research 1996;56(22):5217-23.
1996: Sipos E P; Tebo S A; Zinreich S J; Long D M; Brem H
In vivo accuracy testing and clinical experience with the ISG Viewing Wand.
Neurosurgery 1996;39(1):194-202; discussion 202-4.
1996: Weingart J D; Laterra J J; Brem H
Cerebral gliomas. Growth factors and angiogenesis.
Baillière's clinical neurology 1996;5(2):307-18.
1996: Dang W; Daviau T; Brem H
Morphological characterization of polyanhydride biodegradable implant gliadel during in vitro and in vivo erosion using scanning electron microscopy.
Pharmaceutical research 1996;13(5):683-91.
1996: Fung L K; Shin M; Tyler B; Brem H; Saltzman W M
Chemotherapeutic drugs released from polymers: distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea in the rat brain.
Pharmaceutical research 1996;13(5):671-82.
1996: Olivi A; Ewend M G; Utsuki T; Tyler B; Domb A J; Brat D J; Brem H
Interstitial delivery of carboplatin via biodegradable polymers is effective against experimental glioma in the rat.
Cancer chemotherapy and pharmacology 1996;39(1-2):90-6.
1995: Walter K A; Tamargo R J; Olivi A; Burger P C; Brem H
Intratumoral chemotherapy.
Neurosurgery 1995;37(6):1128-45.
1995: Brem H; Ewend M G; Piantadosi S; Greenhoot J; Burger P C; Sisti M
The safety of interstitial chemotherapy with BCNU-loaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: phase I trial.
Journal of neuro-oncology 1995;26(2):111-23.
1995: Buahin K G; Brem H
Interstitial chemotherapy of experimental brain tumors: comparison of intratumoral injection versus polymeric controlled release.
Journal of neuro-oncology 1995;26(2):103-10.
1995: Sipos E P; Brem H
New delivery systems for brain tumor therapy.
Neurologic clinics 1995;13(4):813-25.
1995: Weingart J D; Thompson R C; Tyler B; Colvin O M; Brem H
Local delivery of the topoisomerase I inhibitor camptothecin sodium prolongs survival in the rat intracranial 9L gliosarcoma model.
International journal of cancer. Journal international du cancer 1995;62(5):605-9.
1995: Weingart J D; Sipos E P; Brem H
The role of minocycline in the treatment of intracranial 9L glioma.
Journal of neurosurgery 1995;82(4):635-40.
1995: Brem H; Piantadosi S; Burger P C; Walker M; Selker R; Vick N A; Black K; Sisti M; Brem S; Mohr G
Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group.
Lancet 1995;345(8956):1008-12.
1995: Pressman E K; Zeidman S M; Reddy U M; Epstein J I; Brem H
Differentiating lymphocytic adenohypophysitis from pituitary adenoma in the peripartum patient.
The Journal of reproductive medicine 1995;40(4):251-9.
1995: Judy K D; Olivi A; Buahin K G; Domb A; Epstein J I; Colvin O M; Brem H
Effectiveness of controlled release of a cyclophosphamide derivative with polymers against rat gliomas.
Journal of neurosurgery 1995;82(3):481-6.
1994: Griffin C A; Hruban R H; Long P P; Miller N; Volz P; Carson B; Brem H
Chromosome abnormalities in meningeal neoplasms: do they correlate with histology?
Cancer genetics and cytogenetics 1994;78(1):46-52.
1994: Sipos E P; Tamargo R J; Weingart J D; Brem H
Inhibition of tumor angiogenesis.
Annals of the New York Academy of Sciences 1994;732():263-72.
1994: Walter K A; Cahan M A; Gur A; Tyler B; Hilton J; Colvin O M; Burger P C; Domb A; Brem H
Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma.
Cancer research 1994;54(8):2207-12.
1994: Dang W; Colvin O M; Brem H; Saltzman W M
Covalent coupling of methotrexate to dextran enhances the penetration of cytotoxicity into a tissue-like matrix.
Cancer research 1994;54(7):1729-35.
1994: Wu M P; Tamada J A; Brem H; Langer R
In vivo versus in vitro degradation of controlled release polymers for intracranial surgical therapy.
Journal of biomedical materials research 1994;28(3):387-95.
1994: Arosarena O; Guerin C; Brem H; Laterra J
Endothelial differentiation in intracerebral and subcutaneous experimental gliomas.
Brain research 1994;640(1-2):98-104.
1994: Phillips P C; Levow C; Catterall M; Colvin O M; Pastan I; Brem H
Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice.
Cancer research 1994;54(4):1008-15.
1994: Brem H; Tamargo R J; Olivi A; Pinn M; Weingart J D; Wharam M; Epstein J I
Biodegradable polymers for controlled delivery of chemotherapy with and without radiation therapy in the monkey brain.
Journal of neurosurgery 1994;80(2):283-90.
1994: Olivi A; Brem H
Interstitial chemotherapy with sustained-release polymer systems for the treatment of malignant gliomas.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1994;135():149-54.
1994: Cahan M A; Walter K A; Colvin O M; Brem H
Cytotoxicity of taxol in vitro against human and rat malignant brain tumors.
Cancer chemotherapy and pharmacology 1994;33(5):441-4.
1994: Tapper D; Cahan M A; Brem H
Detection of biological activity in the cerebrospinal fluid of patients with central nervous system tumors.
Journal of neuro-oncology 1994;19(1):17-23.
1993: Zinreich S J; Tebo S A; Long D M; Brem H; Mattox D E; Loury M E; vander Kolk C A; Koch W M; Kennedy D W; Bryan R N
Frameless stereotaxic integration of CT imaging data: accuracy and initial applications.
Radiology 1993;188(3):735-42.
1993: Wolff J E; Guerin C; Laterra J; Bressler J; Indurti R R; Brem H; Goldstein G W
Dexamethasone reduces vascular density and plasminogen activator activity in 9L rat brain tumors.
Brain research 1993;604(1-2):79-85.
1993: Tamargo R J; Myseros J S; Epstein J I; Yang M B; Chasin M; Brem H
Interstitial chemotherapy of the 9L gliosarcoma: controlled release polymers for drug delivery in the brain.
Cancer research 1993;53(2):329-33.
1993: Olivi A; Gilbert M; Duncan K L; Corden B; Lenartz D; Brem H
Direct delivery of platinum-based antineoplastics to the central nervous system: a toxicity and ultrastructural study.
Cancer chemotherapy and pharmacology 1993;31(6):449-54.
1992: Weingart J; Brem H
Biology and therapy of glial tumors.
Current opinion in neurology and neurosurgery 1992;5(6):808-12.
1992: Guerin C; Laterra J; Masnyk T; Golub L M; Brem H
Selective endothelial growth inhibition by tetracyclines that inhibit collagenase.
Biochemical and biophysical research communications 1992;188(2):740-5.
1992: Phillips S D; Corio R L; Brem H; Mattox D
Ameloblastoma of the mandible with intracranial metastasis. A case study.
Archives of otolaryngology--head & neck surgery 1992;118(8):861-3.
1992: Guerin C; Wolff J E; Laterra J; Drewes L R; Brem H; Goldstein G W
Vascular differentiation and glucose transporter expression in rat gliomas: effects of steroids.
Annals of neurology 1992;31(5):481-7.
1992: Griffin C A; Long P P; Carson B S; Brem H
Chromosome abnormalities in low-grade central nervous system tumors.
Cancer genetics and cytogenetics 1992;60(1):67-73.
1992: Grossman S A; Reinhard C; Colvin O M; Chasin M; Brundrett R; Tamargo R J; Brem H
The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers.
Journal of neurosurgery 1992;76(4):640-7.
1992: Guerin C; Laterra J; Drewes L R; Brem H; Goldstein G W
Vascular expression of glucose transporter in experimental brain neoplasms.
The American journal of pathology 1992;140(2):417-25.
1991: Nabors M W; Griffin C A; Zehnbauer B A; Hruban R H; Phillips P C; Grossman S A; Brem H; Colvin O M
Multidrug resistance gene (MDR1) expression in human brain tumors.
Journal of neurosurgery 1991;75(6):941-6.
1991: Tamargo R J; Sills A K; Reinhard C S; Pinn M L; Long D M; Brem H
Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema.
Journal of neurosurgery 1991;74(6):956-61.
1991: Olivi A; Donehower R C; Mann R B; Brem H
Solitary, isolated metastasis from Ewing's sarcoma to the brain: case report.
Surgical neurology 1991;35(3):239-43.
1991: Brem H; Mahaley M S; Vick N A; Black K L; Schold S C; Burger P C; Friedman A H; Ciric I S; Eller T W; Cozzens J W
Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas.
Journal of neurosurgery 1991;74(3):441-6.
1991: Dugan J D; Lawton M T; Glaser B; Brem H
A new technique for explantation and in vitro cultivation of chicken embryos.
The Anatomical record 1991;229(1):125-8.
1991: Tamargo R J; Bok R A; Brem H
Angiogenesis inhibition by minocycline.
Cancer research 1991;51(2):672-5.
1991: Madrid Y; Langer L F; Brem H; Langer R
New directions in the delivery of drugs and other substances to the central nervous system.
Advances in pharmacology (San Diego, Calif.) 1991;22():299-324.
1990: Guerin C; Laterra J; Hruban R H; Brem H; Drewes L R; Goldstein G W
The glucose transporter and blood-brain barrier of human brain tumors.
Annals of neurology 1990;28(6):758-65.
1990: Brem H
Polymers to treat brain tumours.
Biomaterials 1990;11(9):699-701.
1990: Tamargo R J; Leong K W; Brem H
Growth inhibition of the 9L glioma using polymers to release heparin and cortisone acetate.
Journal of neuro-oncology 1990;9(2):131-8.
1990: Carson B S; Brem H
Neurological surgery.
JAMA : the journal of the American Medical Association 1990;263(19):2658-9.
1990: Brem H
Modern treatment of brain tumors.
Maryland medical journal (Baltimore, Md. : 1985) 1990;39(4):351-4.
1989: Brem H; Beaver B L; Colombani P M; Zinreich J; Scherer L R; Carson B S; Haller J A
Neonatal diagnosis of a presacral mass in the presence of congenital anal stenosis and partial sacral agenesis.
Journal of pediatric surgery 1989;24(10):1076-8.
1989: Langer R; Brem H; Langer L F
New directions in CNS drug delivery.
Neurobiology of aging 1989;10(5):642-4; discussion 648-50.
1989: Yang M B; Tamargo R J; Brem H
Controlled delivery of 1,3-bis(2-chloroethyl)-1-nitrosourea from ethylene-vinyl acetate copolymer.
Cancer research 1989;49(18):5103-7.
1989: Steen R G; Tamargo R J; Brem H; Glickson J D; Wehrle J P
In vivo 31P nuclear magnetic resonance spectroscopy of rat 9L gliosarcoma treated with BCNU: dose response of spectral changes.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1989;11(2):258-66.
1989: Salibi S S; Nauta H J; Brem H; Epstein J I; Cho K R
Lipomeningioma: report of three cases and review of the literature.
Neurosurgery 1989;25(1):122-6.
1989: Tamargo R J; Epstein J I; Reinhard C S; Chasin M; Brem H
Brain biocompatibility of a biodegradable, controlled-release polymer in rats.
Journal of biomedical materials research 1989;23(2):253-66.
1989: Brem H; Kader A; Epstein J I; Tamargo R J; Domb A; Langer R; Leong K W
Biocompatibility of a biodegradable, controlled-release polymer in the rabbit brain.
Selective cancer therapeutics 1989;5(2):55-65.
1989: Levy A P; Tamargo R; Brem H; Nathans D
An endothelial cell growth factor from the mouse neuroblastoma cell line NB41.
Growth factors (Chur, Switzerland) 1989;2(1):9-19.
1988: Tamargo R J; Epstein J I; Brem H
Heterotransplantation of malignant human gliomas in neonatal rats.
Journal of neurosurgery 1988;69(6):928-33.
1988: Robey S S; Olson J L; Brem H; Epstein J I
Posterior fossa neuroblastoma occurring in an elderly man.
Human pathology 1988;19(3):365-7.
1988: Steen R G; Tamargo R J; McGovern K A; Rajan S S; Brem H; Wehrle J P; Glickson J D
In vivo 31P nuclear magnetic resonance spectroscopy of subcutaneous 9L gliosarcoma: effects of tumor growth and treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea on tumor bioenergetics and histology.
Cancer research 1988;48(3):676-81.
1986: Zinreich S J; Wang H; Epstein J I; Kim W S; Brem H; Anderson J H; Ahn H S; Rosenbaum A E
Carotid bifurcation imaging model for more accurately comparing imaging techniques.
Acta radiologica. Supplementum 1986;369():24-8.
1983: Friedman J H; Brem H; Mayeux R
Global aphasia in multiple sclerosis.
Annals of neurology 1983;13(2):222-3.
1981: Langer R; Brem H; Tapper D
Biocompatibility of polymeric delivery systems for macromolecules.
Journal of biomedical materials research 1981;15(2):267-77.
1977: Preis I; Langer R; Brem H; Folkman J
Inhibition of neovascularization by an extract derived from vitreous.
American journal of ophthalmology 1977;84(3):323-8.
1976: Brem S; Brem H; Folkman J; Finkelstein D; Patz A
Prolonged tumor dormancy by prevention of neovascularization in the vitreous.
Cancer research 1976;36(8):2807-12.
1976: Langer R; Brem H; Falterman K; Klein M; Folkman J
Isolations of a cartilage factor that inhibits tumor neovascularization.
Science (New York, N.Y.) 1976;193(4247):70-2.
1975: Brem H; Folkman J
Inhibition of tumor angiogenesis mediated by cartilage.
The Journal of experimental medicine 1975;141(2):427-39.
1974: Brem H; Stein A B; Rosenkranz H S
The mutagenicity and DNA-modifying effect of haloalkanes.
Cancer research 1974;34(10):2576-9.
1974: Brem H; Coward J E; Rosenkranz H S
1,2-dibromoethane--effect on the metabolism and ultrastructure of Escherichia coli.
Biochemical pharmacology 1974;23(16):2345-7.

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