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Masuo Akahane

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Fumiki Oana; Hiroo Takeda; Akane Matsuzawa; Satoshi Akahane; Morimichi Hayashi; Toru Tamura; Miyuki Uehara; Masayuki Isaji; Masuo Akahane
KTO-7924, a Beta3-adrenergic receptor agonist, reduces hyperglycemia, and protects beta-cells in the islets of langerhans of db/db mice.
Fumiki Oana; Toshiki Homma; Hiroo Takeda; Akane Matsuzawa; Satoshi Akahane; Masayuki Isaji; Masuo Akahane
DNA microarray analysis of white adipose tissue from obese (fa/fa) Zucker rats treated with a beta3-adrenoceptor agonist, KTO-7924.
Fumiki Oana; Hiroo Takeda; Kohichi Hayakawa; Akane Matsuzawa; Satoshi Akahane; Masayuki Isaji; Masuo Akahane
Physiological difference between obese (fa/fa) Zucker rats and lean Zucker rats concerning adiponectin.

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2010: Fumiki Oana; Hiroo Takeda; Akane Matsuzawa; Satoshi Akahane; Morimichi Hayashi; Toru Tamura; Miyuki Uehara; Masayuki Isaji; Masuo Akahane
KTO-7924, a Beta3-adrenergic receptor agonist, reduces hyperglycemia, and protects beta-cells in the islets of langerhans of db/db mice.
Endocrine research 2010;35(4):174-82.
2005: Fumiki Oana; Toshiki Homma; Hiroo Takeda; Akane Matsuzawa; Satoshi Akahane; Masayuki Isaji; Masuo Akahane
DNA microarray analysis of white adipose tissue from obese (fa/fa) Zucker rats treated with a beta3-adrenoceptor agonist, KTO-7924.
Pharmacological research : the official journal of the Italian Pharmacological Society 2005;52(5):395-400.
2005: Fumiki Oana; Hiroo Takeda; Kohichi Hayakawa; Akane Matsuzawa; Satoshi Akahane; Masayuki Isaji; Masuo Akahane
Physiological difference between obese (fa/fa) Zucker rats and lean Zucker rats concerning adiponectin.
Metabolism: clinical and experimental 2005;54(8):995-1001.
2005: Fumiki Oana; Hiroo Takeda; Akane Matsuzawa; Satoshi Akahane; Masayuki Isaji; Masuo Akahane
Adiponectin receptor 2 expression in liver and insulin resistance in db/db mice given a beta3-adrenoceptor agonist.
European journal of pharmacology 2005;518(1):71-6.
2003: Yoshitaka Tomiyama; Makoto Murakami; Kohichi Hayakawa; Katsuyoshi Akiyama; Yoshinobu Yamazaki; Masami Kojima; Nobuo Shibata; Masuo Akahane
Pharmacological profile of KUL-7211, a selective beta-adrenoceptor agonist, in isolated ureteral smooth muscle.
Journal of pharmacological sciences 2003;92(4):411-9.
2003: Hiroo Takeda; Akane Matsuzawa; Yasuhiko Igawa; Yoshinobu Yamazaki; Kouichi Kaidoh; Satoshi Akahane; Masami Kojima; Hiroshi Miyata; Masuo Akahane; Osamu Nishizawa
Functional characterization of beta-adrenoceptor subtypes in the canine and rat lower urinary tract.
The Journal of urology 2003;170(2 Pt 1):654-8.
2003: Nobuyuki Tanaka; Tetsuro Tamai; Harunobu Mukaiyama; Akihito Hirabayashi; Hideyuki Muranaka; Takehiro Ishikawa; Junichi Kobayashi; Satoshi Akahane; Masuo Akahane
Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence.
Journal of medicinal chemistry 2003;46(1):105-12.
2002: Hiroo Takeda; Yoshinobu Yamazaki; Yasuhiko Igawa; Kouichi Kaidoh; Satoshi Akahane; Hiroshi Miyata; Osamu Nishizawa; Masuo Akahane; Karl-Erik Andersson
Effects of beta(3)-adrenoceptor stimulation on prostaglandin E(2)-induced bladder hyperactivity and on the cardiovascular system in conscious rats.
Neurourology and urodynamics 2002;21(6):558-65.
2002: Hiroo Takeda; Yoshinobu Yamazaki; Masuo Akahane; Satoshi Akahane; Hiroshi Miyata; Yasuhiko Igawa; Osamu Nishizawa
Characterization of beta-adrenoceptor subtype in bladder smooth muscle in cynomolgus monkey.
Japanese journal of pharmacology 2002;88(1):108-13.
2001: Nobuyuki Tanaka; Tetsuro Tamai; Harunobu Mukaiyama; Akihito Hirabayashi; Hideyuki Muranaka; T Ishikawa; Satoshi Akahane; Masuo Akahane
Beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence: 2-[4-(2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl)phenoxy]-2-methylpropionic acid.
Bioorganic & medicinal chemistry 2001;9(12):3265-71.
2001: Nobuyuki Tanaka; Tetsuro Tamai; Harunobu Mukaiyama; Akihito Hirabayashi; Hideyuki Muranaka; Satoshi Akahane; Hiroshi Miyata; Masuo Akahane
Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence.
Journal of medicinal chemistry 2001;44(9):1436-45.
2001: Yasuhiko Igawa; Yoshinobu Yamazaki; Hiroo Takeda; Kouichi Kaidoh; Masuo Akahane; Yukiyoshi Ajisawa; T Yoneyama; Osamu Nishizawa; Karl-Erik Andersson
Relaxant effects of isoproterenol and selective beta3-adrenoceptor agonists on normal, low compliant and hyperreflexic human bladders.
The Journal of urology 2001;165(1):240-4.
2000: Young-Chol Park; Y Tomiyama; K Hayakawa; Masuo Akahane; Yukiyoshi Ajisawa; R Miyatake; H Kiwamoto; T Sugiyama; Takashi Kurita
Existence of a beta3-adrenoceptro and its functional role in the human ureter.
The Journal of urology 2000;164(4):1364-70.
2000: Hiroo Takeda; Yasuhiko Igawa; Y Komatsu; Yoshinobu Yamazaki; Masuo Akahane; Osamu Nishizawa; Yukiyoshi Ajisawa
Characterization of beta-adrenoceptor subtypes in the ferret urinary bladder in vitro and in vivo.
European journal of pharmacology 2000;403(1-2):147-55.
2000: Hiroo Takeda; Yoshinobu Yamazaki; Masuo Akahane; Yasuhiko Igawa; Yukiyoshi Ajisawa; Osamu Nishizawa
Role of the beta(3)-adrenoceptor in urine storage in the rat: comparison between the selective beta(3)-adrenoceptor agonist, CL316, 243, and various smooth muscle relaxants.
The Journal of pharmacology and experimental therapeutics 2000;293(3):939-45.
2000: M Murakami; Y Tomiyama; K Hayakawa; Masuo Akahane; Yukiyoshi Ajisawa; Young-Chol Park; N Ohnishi; T Sugiyama; Takashi Kurita
Effects of beta-adrenergic stimulation on the acutely obstructed ureter in dogs.
The Journal of pharmacology and experimental therapeutics 2000;292(1):67-75.
1999: M Kobayashi; Masuo Akahane; K Minami; M Moro; Yukiyoshi Ajisawa; Y Inoue; T Kawarabayashi
Role of oxytocin in the initiation of term and preterm labor in rats: changes in oxytocin receptor density and plasma oxytocin concentration and the effect of an oxytocin antagonist, L-366,509.
American journal of obstetrics and gynecology 1999;180(3 Pt 1):621-7.
1999: Yasuhiko Igawa; Yoshinobu Yamazaki; Hiroo Takeda; K Hayakawa; Masuo Akahane; Yukiyoshi Ajisawa; T Yoneyama; Osamu Nishizawa; Karl-Erik Andersson
Functional and molecular biological evidence for a possible beta3-adrenoceptor in the human detrusor muscle.
British journal of pharmacology 1999;126(3):819-25.
1998: K Miyazawa; A Mori; Hiroshi Miyata; Masuo Akahane; Yukiyoshi Ajisawa; H Okudaira
Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase.
The Journal of biological chemistry 1998;273(38):24832-8.
1998: Yasuhiko Igawa; Yoshinobu Yamazaki; Hiroo Takeda; Masuo Akahane; Yukiyoshi Ajisawa; T Yoneyama; Osamu Nishizawa
Possible beta 3-adrenoceptor-mediated relaxation of the human detrusor.
Acta physiologica Scandinavica 1998;164(1):117-8.
1998: Y Tomiyama; K Hayakawa; K Shinagawa; Masuo Akahane; Yukiyoshi Ajisawa; Young-Chol Park; Takashi Kurita
Beta-adrenoceptor subtypes in the ureteral smooth muscle of rats, rabbits and dogs.
European journal of pharmacology 1998;352(2-3):269-78.
1998: Yoshinobu Yamazaki; Hiroo Takeda; Masuo Akahane; Yasuhiko Igawa; Osamu Nishizawa; Yukiyoshi Ajisawa
Species differences in the distribution of beta-adrenoceptor subtypes in bladder smooth muscle.
British journal of pharmacology 1998;124(3):593-9.
1996: Tatsuhiko Kawarabayashi; M Kobayashi; Masuo Akahane; Yukiyoshi Ajisawa
Comparison of in vitro and in vivo inhibitory effects of peptide and nonpeptide oxytocin antagonists on radioligand binding and uterine contractility of rats during pregnancy.
American journal of obstetrics and gynecology 1996;175(5):1348-55.
1996: Yukiyoshi Ajisawa; K Akahane; Masuo Akahane; K Sato; T Tamai; M Saito; N Tanaka; K Kamata; M Kobayashi
[Studies on the synthesis of cholecystokinin A receptor antagonists. IV. Synthesis and cholecystokinin A receptor inhibitory activities of benzimidazole derivatives].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1996;116(9):735-47.
1996: M Kobayashi; K Shinagawa; M Sugiura; T Nagasawa; Masuo Akahane; Yukiyoshi Ajisawa
[Effect of KSG-504, a new CCK-A-receptor antagonist, on experimental acute pancreatitis in rats and mice].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1996;107(4):183-95.
1996: Yoshinobu Yamazaki; Masuo Akahane; M Kobayashi; H Takeda; Yukiyoshi Ajisawa
Effects of KSG-504, a new cholecystokinin-A-receptor antagonist, on pancreatic exocrine and endocrine secretions in rats.
Japanese journal of pharmacology 1996;70(2):183-90.
1996: Yoshinobu Yamazaki; Masuo Akahane; M Kobayashi; K Shinagawa; M Sugiura; Yukiyoshi Ajisawa
[Effects of KSG-504, a new CCK-A receptor antagonist, on gallbladder and gastrointestinal functions].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1996;107(1):33-44.
1996: Yoshinobu Yamazaki; H Takeda; Masuo Akahane; A Tsubaki; Yukiyoshi Ajisawa
[Behavioral studies of KSG-504, a new CCK-A receptor antagonist].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1996;107(1):21-31.
1995: Yoshinobu Yamazaki; K Shinagawa; H Takeda; M Kobayashi; Masuo Akahane; Yukiyoshi Ajisawa
Cholecystokinin-A specific antagonism of KSG-504 to cholecystokinin receptor binding and pancreatic secretion in mammals.
Japanese journal of pharmacology 1995;69(4):367-73.