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John Wood

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Chemicals & Drugs

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Oxidation-Reduction

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Karin U Schallreuter; Sybille Hasse; Hartmut Rokos; Bhaven Chavan; Mohamed Shalbaf; Jennifer D Spencer; John M Wood
Cholesterol regulates melanogenesis in human epidermal melanocytes and melanoma cells.
John M Wood; Heinz Decker; H Hartmann; Bhaven Chavan; Hartmut Rokos; Jennifer D Spencer; Sybille Hasse; M Julie Thornton; M Shalbaf; Ralf Paus; Karin U Schallreuter
Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair.
Bhaven Chavan; Wayne D Beazley; John M Wood; Hartmut Rokos; H Ichinose; Karin U Schallreuter
H(2)O(2) increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo.

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2009: Karin U Schallreuter; Sybille Hasse; Hartmut Rokos; Bhaven Chavan; Mohamed Shalbaf; Jennifer D Spencer; John M Wood
Cholesterol regulates melanogenesis in human epidermal melanocytes and melanoma cells.
Experimental dermatology 2009;18(8):680-8.
2009: John M Wood; Heinz Decker; H Hartmann; Bhaven Chavan; Hartmut Rokos; Jennifer D Spencer; Sybille Hasse; M Julie Thornton; M Shalbaf; Ralf Paus; Karin U Schallreuter
Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(7):2065-75.
2009: Bhaven Chavan; Wayne D Beazley; John M Wood; Hartmut Rokos; H Ichinose; Karin U Schallreuter
H(2)O(2) increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo.
Journal of inherited metabolic disease 2009;32(1):86-94.
2008: Mohammad Shalbaf; Nicholas C J Gibbons; John M Wood; Derek J Maitland; Hartmut Rokos; Souna M Elwary; Lee K Marles; Karin U Schallreuter
Presence of epidermal allantoin further supports oxidative stress in vitiligo.
Experimental dermatology 2008;17(9):761-70.
2008: Karin U Schallreuter; Christian Krüger; Brigitte A Würfel; Angela Panske; John M Wood
From basic research to the bedside: efficacy of topical treatment with pseudocatalase PC-KUS in 71 children with vitiligo.
International journal of dermatology 2008;47(7):743-53.
2008: John M Wood; Karin U Schallreuter
A plaidoyer for cutaneous enzymology: our view of some important unanswered questions on the contributions of selected key enzymes to epidermal homeostasis.
Experimental dermatology 2008;17(7):569-78.
2008: John M Wood; Nicholas C J Gibbons; Bhaven Chavan; Karin U Schallreuter
Computer simulation of heterogeneous single nucleotide polymorphisms in the catalase gene indicates structural changes in the enzyme active site, NADPH-binding and tetramerization domains: a genetic predisposition for an altered catalase in patients with vitiligo?
Experimental dermatology 2008;17(4):366-71.
2008: Karin U Schallreuter; Katharina Rübsam; Nicholas C J Gibbons; Derek J Maitland; Bhaven Chavan; Carsten Zothner; Hartmut Rokos; John M Wood
Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo.
The Journal of investigative dermatology 2008;128(4):808-15.
2008: Karin U Schallreuter; Hartmut Rokos; Bhaven Chavan; Johanna M Gillbro; Eduardo Cemeli; Carsten Zothner; Diana Anderson; John M Wood
Quinones are reduced by 6-tetrahydrobiopterin in human keratinocytes, melanocytes, and melanoma cells.
Free radical biology & medicine 2008;44(4):538-46.
2007: Karin U Schallreuter; Yuwang Wei; Mark Pittelkow; Norma N Swanson; Nicholas C J Gibbons; John M Wood
Structural and functional alterations in the beta2-adrenoceptor are caused by a point mutation in patients with atopic eczema.
Experimental dermatology 2007;16(10):807-13.
2007: Karin U Schallreuter; Nicholas C J Gibbons; Carsten Zothner; M M Abou Elloof; John M Wood
Hydrogen peroxide-mediated oxidative stress disrupts calcium binding on calmodulin: more evidence for oxidative stress in vitiligo.
Biochemical and biophysical research communications 2007;360(1):70-5.
2007: Karin U Schallreuter; Nicholas C J Gibbons; Souna Elwary; Susan M Parkin; John M Wood
Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates.
Biochemical and biophysical research communications 2007;355(4):1069-74.
2007: Jennifer D Spencer; Nicholas C J Gibbons; Hartmut Rokos; Eva M J Peters; John M Wood; Karin U Schallreuter
Oxidative stress via hydrogen peroxide affects proopiomelanocortin peptides directly in the epidermis of patients with vitiligo.
The Journal of investigative dermatology 2007;127(2):411-20.
2006: Nicholas C J Gibbons; John M Wood; Hartmut Rokos; Karin U Schallreuter
Computer simulation of native epidermal enzyme structures in the presence and absence of hydrogen peroxide (H2O2): potential and pitfalls.
The Journal of investigative dermatology 2006;126(12):2576-82.
2006: Karin U Schallreuter; Nicholas C J Gibbons; Carsten Zothner; Souna Elwary; Hartmut Rokos; John M Wood
Butyrylcholinesterase is present in the human epidermis and is regulated by H2O2: more evidence for oxidative stress in vitiligo.
Biochemical and biophysical research communications 2006;349(3):931-8.
2006: Karin U Schallreuter; Georgia Chiuchiarelli; Eduardo Cemeli; Souna Elwary; Johanna M Gillbro; Jennifer D Spencer; Hartmut Rokos; Angela Panske; Bhaven Chavan; John M Wood; Diana Anderson
Estrogens can contribute to hydrogen peroxide generation and quinone-mediated DNA damage in peripheral blood lymphocytes from patients with vitiligo.
The Journal of investigative dermatology 2006;126(5):1036-42.
2006: Karin U Schallreuter; Katharina Rübsam; Bhaven Chavan; Carsten Zothner; Johanna M Gillbro; Jennifer D Spencer; John M Wood
Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus.
Biochemical and biophysical research communications 2006;342(1):145-52.
2006: John M Wood; Nicholas C J Gibbons; Karin U Schallreuter
Melanocortins in human melanocytes.
Cellular and molecular biology (Noisy-le-Grand, France) 2006;52(2):75-8.
2006: John M Wood; Karin U Schallreuter
UVA-irradiated pheomelanin alters the structure of catalase and decreases its activity in human skin.
The Journal of investigative dermatology 2006;126(1):13-4.
2005: Karin U Schallreuter; Bhaven Chavan; Hartmut Rokos; Nigel A Hibberts; Angela Panske; John M Wood
Decreased phenylalanine uptake and turnover in patients with vitiligo.
Molecular genetics and metabolism 2005;86 Suppl 1():S27-33.
2005: John M Wood; Bhaven Chavan; Idris Hafeez; Karin U Schallreuter
Regulation of tyrosinase by tetrahydropteridines--what is real? A critical reanalysis of H. Wojtasek's view.
Biochemical and biophysical research communications 2005;331(4):891-3.
2004: John M Wood; Bhaven Chavan; Idris Hafeez; Karin U Schallreuter
Regulation of tyrosinase by tetrahydropteridines and H2O2.
Biochemical and biophysical research communications 2004;325(4):1412-7.
2004: Karin U Schallreuter; Umar Wazir; Sonal Kothari; Nicholas C J Gibbons; Jeremy Moore; John M Wood
Human phenylalanine hydroxylase is activated by H2O2: a novel mechanism for increasing the L-tyrosine supply for melanogenesis in melanocytes.
Biochemical and biophysical research communications 2004;322(1):88-92.
2004: Martin J Hoogduijn; Eduardo Cemeli; K Ross; Diana Anderson; Anthony J Thody; John M Wood
Melanin protects melanocytes and keratinocytes against H2O2-induced DNA strand breaks through its ability to bind Ca2+.
Experimental cell research 2004;294(1):60-7.
2004: Karin U Schallreuter; Souna Elwary; Nicholas C J Gibbons; Hartmut Rokos; John M Wood
Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo.
Biochemical and biophysical research communications 2004;315(2):502-8.
2003: Diana Anderson; Thomas E Schmid; Adolf Baumgartner; Eduardo Cemeli-Carratala; Martin H Brinkworth; John M Wood
Oestrogenic compounds and oxidative stress (in human sperm and lymphocytes in the Comet assay).
Mutation research 2003;544(2-3):173-8.
2003: Martin J Hoogduijn; Nico P M Smit; A van der Laarse; A F van Nieuwpoort; John M Wood; Anthony J Thody
Melanin has a role in Ca2+ homeostasis in human melanocytes.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2003;16(2):127-32.
2003: Karin U Schallreuter; Sonal Kothari; Sybille Hasse; Söbia Kauser; Nigel J Lindsey; Nicholas C J Gibbons; Nigel A Hibberts; John M Wood
In situ and in vitro evidence for DCoH/HNF-1 alpha transcription of tyrosinase in human skin melanocytes.
Biochemical and biophysical research communications 2003;301(2):610-6.
2001: Karin U Schallreuter; John M Wood
Thioredoxin reductase - its role in epidermal redox status.
Journal of photochemistry and photobiology. B, Biology 2001;64(2-3):179-84.
2001: Karin U Schallreuter; Jeremy Moore; John M Wood; Wayne D Beazley; Eva M J Peters; Lee K Marles; Stefanie Behrens-Williams; R Dummer; N Blau; B Thöny
Epidermal H(2)O(2) accumulation alters tetrahydrobiopterin (6BH4) recycling in vitiligo: identification of a general mechanism in regulation of all 6BH4-dependent processes?
The Journal of investigative dermatology 2001;116(1):167-74.
1999: Jeremy Moore; John M Wood; Karin U Schallreuter
Evidence for specific complex formation between alpha-melanocyte stimulating hormone and 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin using near infrared Fourier transform Raman spectroscopy.
Biochemistry 1999;38(46):15317-24.
1999: Karin U Schallreuter; Jeremy Moore; Desmond J Tobin; N J Gibbons; H S Marshall; Tracey J Jenner; Wayne D Beazley; John M Wood
alpha-MSH can control the essential cofactor 6-tetrahydrobiopterin in melanogenesis.
Annals of the New York Academy of Sciences 1999;885():329-41.
1999: Karin U Schallreuter; Jeremy Moore; John M Wood; Wayne D Beazley; David Gaze; Desmond J Tobin; H S Marshall; Angela Panske; E Panzig; Nigel A Hibberts
In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1999;4(1):91-6.
1999: Karin U Schallreuter; John M Wood
The importance of L-phenylalanine transport and its autocrine turnover to L-tyrosine for melanogenesis in human epidermal melanocytes.
Biochemical and biophysical research communications 1999;262(2):423-8.
1999: John M Wood; K Jimbow; RE Boissy; Andrzej Slominski; Przemyslaw Plonka; J Slawinski; Jacobo Wortsman; J Tosk
What's the use of generating melanin?
Experimental dermatology 1999;8(2):153-64.
1999: Janis Ancans; Anthony J Thody; John M Wood; Wayne D Beazley; Karin U Schallreuter
Human epidermal proopiomelanocortin (POMC) cDNA variant is identical to mouse POMC cDNA.
The Journal of investigative dermatology 1999;112(4):516-7.
1998: Karin U Schallreuter; Wayne D Beazley; Nigel A Hibberts; Desmond J Tobin; Ralf Paus; John M Wood
Pterins in human hair follicle cells and in the synchronized murine hair cycle.
The Journal of investigative dermatology 1998;111(4):545-50.
1998: Karin U Schallreuter; John M Wood; C Körner; K M Harle; V Schulz-Douglas; E R Werner
6-Tetrahydrobiopterin functions as a UVB-light switch for de novo melanogenesis.
Biochimica et biophysica acta 1998;1382(2):339-44.
1996: Karin U Schallreuter; John M Wood; Dennis W Farwell; J Moore; Howell G M Edwards
Oxybenzone oxidation following solar irradiation of skin: photoprotection versus antioxidant inactivation.
The Journal of investigative dermatology 1996;106(3):583-6.
1996: Karin U Schallreuter; John M Wood; Mark Pittelkow; G Buttner; Neil A Swanson; C Korner; C Ehrke
Increased monoamine oxidase A activity in the epidermis of patients with vitiligo.
Archives of dermatological research 1996;288(1):14-8.
1995: Karin U Schallreuter; K R Lemke; Mark Pittelkow; John M Wood; C Körner; R Malik
Catecholamines in human keratinocyte differentiation.
The Journal of investigative dermatology 1995;104(6):953-7.
1995: John M Wood; K U Schallreuter-Wood; Nigel J Lindsey; S Callaghan; M L Gardner
A specific tetrahydrobiopterin binding domain on tyrosinase controls melanogenesis.
Biochemical and biophysical research communications 1995;206(2):480-5.
1995: Karin U Schallreuter; John M Wood; K R Lemke; C Levenig
Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB exposure: a case study on 33 patients.
Dermatology (Basel, Switzerland) 1995;190(3):223-9.
1994: Karin U Schallreuter; K R Lemke; Helene Hill; John M Wood
Thioredoxin reductase induction coincides with melanin biosynthesis in brown and black guinea pigs and in murine melanoma cells.
The Journal of investigative dermatology 1994;103(6):820-4.
1994: Karin U Schallreuter; G Büttner; Mark Pittelkow; John M Wood; Norma N Swanson; C Körner
Cytotoxicity of 6-biopterin to human melanocytes.
Biochemical and biophysical research communications 1994;204(1):43-8.
1994: Karin U Schallreuter; John M Wood; I Ziegler; K R Lemke; Mark Pittelkow; N J Lindsey; M Gütlich
Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo.
Biochimica et biophysica acta 1994;1226(2):181-92.
1994: Karin U Schallreuter; John M Wood; Mark Pittelkow; M Gütlich; K R Lemke; W Rödl; Norma N Swanson; K Hitzemann; I Ziegler
Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin.
Science (New York, N.Y.) 1994;263(5152):1444-6.
1993: John M Wood; P E Evans; Karin U Schallreuter; W E Jacobson; R Sufit; J Newman; C White; M Jacobson
A multicenter study on the use of pulsed low-intensity direct current for healing chronic stage II and stage III decubitus ulcers.
Archives of dermatology 1993;129(8):999-1009.
1993: Karin U Schallreuter; John M Wood; Mark Pittelkow; Norma N Swanson; V Steinkraus
Increased in vitro expression of beta 2-adrenoceptors in differentiating lesional keratinocytes of vitiligo patients.
Archives of dermatological research 1993;285(4):216-20.
1993: Karin U Schallreuter; E Frenk; L S Wolfe; C J Witkop; John M Wood
Hermansky-Pudlak syndrome in a Swiss population.
Dermatology (Basel, Switzerland) 1993;187(4):248-56.
1992: Karin U Schallreuter; John M Wood; R Lemke; C LePoole; P Das; W Westerhof; Mark Pittelkow; A J Thody
Production of catecholamines in the human epidermis.
Biochemical and biophysical research communications 1992;189(1):72-8.
1992: Karin U Schallreuter; John M Wood; C Ehrke; R Lemke
Calcium transport and regulation in human primary and metastatic melanoma.
Biochimica et biophysica acta 1992;1160(1):127-33.
1991: Karin U Schallreuter; John M Wood; J Berger
Low catalase levels in the epidermis of patients with vitiligo.
The Journal of investigative dermatology 1991;97(6):1081-5.
1991: John M Wood; Karin U Schallreuter
Studies on the reactions between human tyrosinase, superoxide anion, hydrogen peroxide and thiols.
Biochimica et biophysica acta 1991;1074(3):378-85.
1991: Karin U Schallreuter; John M Wood
New aspects in the pathophysiology of cutaneous melanoma: a review of the role of thioproteins and the effect of nitrosoureas.
Melanoma research 1991;1(3):159-67.
1991: John M Wood; C Ehrke; Karin U Schallreuter
Tryptophan protects human melanoma cells against gamma-interferon and tumour necrosis factor-alpha: a unifying mechanism of action.
Melanoma research 1991;1(3):177-85.
1991: Karin U Schallreuter; John M Wood
Sensitivity and resistance in human metastatic melanoma to the new chloroethylnitrosourea anti-tumor drug Fotemustine.
Biochimica et biophysica acta 1991;1096(4):277-83.
1991: Karin U Schallreuter; M Jänner; H Mensing; Eckard W Breitbart; J Berger; John M Wood
Thioredoxin reductase activity at the surface of human primary cutaneous melanomas and their surrounding skin.
International journal of cancer. Journal international du cancer 1991;48(1):15-9.
1991: Karin U Schallreuter; T Grebe; Mark Pittelkow; John M Wood
[3H]-13-cis-retinoic acid covalently binds to thioredoxin reductase in human keratinocytes.
Skin pharmacology : the official journal of the Skin Pharmacology Society 1991;4(1):14-20.
1991: Karin U Schallreuter; Mark Pittelkow; John M Wood
Defects in antioxidant defense and calcium transport in the epidermis of xeroderma pigmentosum patients.
Archives of dermatological research 1991;283(7):449-55.
1991: Karin U Schallreuter; John M Wood; H Mensing; Eckard W Breitbart
Local treatment of cutaneous and subcutaneous metastatic malignant melanoma with fotemustine.
Cancer chemotherapy and pharmacology 1991;29(2):167-71.
1990: Karin U Schallreuter; F K Gleason; John M Wood
The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase.
Biochimica et biophysica acta 1990;1054(1):14-20.
1989: Karin U Schallreuter; John M Wood
Calcium regulates thioredoxin reductase in human metastatic melanoma.
Biochimica et biophysica acta 1989;997(3):242-7.
1989: Karin U Schallreuter; Mark Pittelkow; John M Wood
EF-hands calcium binding regulates the thioredoxin reductase/thioredoxin electron transfer in human keratinocytes.
Biochemical and biophysical research communications 1989;162(3):1311-6.
1989: Karin U Schallreuter; John M Wood
The stereospecific suicide inhibition of human melanoma thioredoxin reductase by 13-cis-retinoic acid.
Biochemical and biophysical research communications 1989;160(2):573-9.
1989: Karin U Schallreuter; John M Wood
Thioredoxin reductase in control of the pigmentary system.
Clinics in dermatology 1989;7(2):92-105.
1988: Karin U Schallreuter; John M Wood
The activity and purification of membrane-associated thioredoxin reductase from human metastatic melanotic melanoma.
Biochimica et biophysica acta 1988;967(1):103-9.
1987: Karin U Schallreuter; John M Wood
Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells.
Cancer letters 1987;36(3):297-305.