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Jeanette Wood

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Terence O'Reilly; Heidi A Lane; Jeanette M Wood; Christian R Schnell; Amanda Littlewood-Evans; Josef Brueggen; Paul M J McSheehy
Everolimus and PTK/ZK show synergistic growth inhibition in the orthotopic BL16/BL6 murine melanoma model.
Georg Martiny-Baron; Philipp Holzer; Eric Billy; Christian R Schnell; Josef Brueggen; Mireille Ferretti; Niko Schmiedeberg; Jeanette M Wood; Pascal Furet; Patricia Imbach
The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis.
Yasuchika Yamaguchi; Keith Menear; Nissim-Claude Cohen; Robert Mah; Frédéric Cumin; Christian Schnell; Jeanette M Wood; Jürgen Maibaum
The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.

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All Publications

2011: Terence O'Reilly; Heidi A Lane; Jeanette M Wood; Christian R Schnell; Amanda Littlewood-Evans; Josef Brueggen; Paul M J McSheehy
Everolimus and PTK/ZK show synergistic growth inhibition in the orthotopic BL16/BL6 murine melanoma model.
Cancer chemotherapy and pharmacology 2011;67(1):193-200.
2010: Georg Martiny-Baron; Philipp Holzer; Eric Billy; Christian R Schnell; Josef Brueggen; Mireille Ferretti; Niko Schmiedeberg; Jeanette M Wood; Pascal Furet; Patricia Imbach
The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis.
Angiogenesis 2010;13(3):259-67.
2009: Yasuchika Yamaguchi; Keith Menear; Nissim-Claude Cohen; Robert Mah; Frédéric Cumin; Christian Schnell; Jeanette M Wood; Jürgen Maibaum
The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.
Bioorganic & medicinal chemistry letters 2009;19(16):4863-7.
2007: Jürgen Maibaum; Stefan Stutz; Richard Göschke; Pascal Rigollier; Yasuchika Yamaguchi; Frederic Cumin; Joseph Rahuel; Hans-Peter Baum; Nissim-Claude Cohen; Christian R Schnell; Walter Fuhrer; Markus G Gruetter; Walter Schilling; Jeanette M Wood
Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets.
Journal of medicinal chemistry 2007;50(20):4832-44.
2007: Richard Göschke; Stefan Stutz; Vittorio Rasetti; Nissim-Claude Cohen; Joseph Rahuel; Pascal Rigollier; Hans-Peter Baum; Peter Forgiarini; Christian R Schnell; Trixie Wagner; Markus G Gruetter; Walter Fuhrer; Walter Schilling; Frederic Cumin; Jeanette M Wood; Jürgen Maibaum
Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin.
Journal of medicinal chemistry 2007;50(20):4818-31.
2005: Jeanette M Wood; Christian R Schnell; Frederic Cumin; Joël Menard; Randy L Webb
Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats.
Journal of hypertension 2005;23(2):417-26.
2003: Jeanette M Wood; Jürgen Maibaum; Joseph Rahuel; Markus G Grütter; Nissim-Claude Cohen; Vittorio Rasetti; Heinrich Rüger; Richard Göschke; Stefan Stutz; Walter Fuhrer; Walter Schilling; Pascal Rigollier; Yasuchika Yamaguchi; Frederic Cumin; Hans-Peter Baum; Christian R Schnell; Peter Herold; Robert Mah; Chris Jensen; Eoin O'Brien; Alice Stanton; Martin P Bedigian
Structure-based design of aliskiren, a novel orally effective renin inhibitor.
Biochemical and biophysical research communications 2003;308(4):698-705.
2002: Paul W Manley; Georg Martiny-Baron; Jean-Marc Schlaeppi; Jeanette M Wood
Therapies directed at vascular endothelial growth factor.
Expert opinion on investigational drugs 2002;11(12):1715-36.
2000: Joseph Rahuel; Vittorio Rasetti; Jürgen Maibaum; H Rüeger; Richard Göschke; Nissim-Claude Cohen; Stefan Stutz; Frederic Cumin; Walter Fuhrer; Jeanette M Wood; M G Grütter
Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin.
Chemistry & biology 2000;7(7):493-504.
2000: Jeanette M Wood; Guido Bold; Elisabeth Buchdunger; Robert Cozens; S Ferrari; Joerg Frei; Francesco Hofmann; Jürgen Mestan; Helmut Mett; Terence O'Reilly; E Persohn; J Rösel; Christian R Schnell; DR Stover; A Theuer; H Towbin; Fritz Wenger; K Woods-Cook; Andreas Menrad; Gerhard Siemeister; Michael Schirner; Karl-Heinz Thierauch; Martin R Schneider; Joachim Drevs; Georg Martiny-Baron; Frank Totzke
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.
Cancer research 2000;60(8):2178-89.
2000: Jeanette M Wood
Inhibition of vascular endothelial growth factor (VEGF) as a novel approach for cancer therapy.
Medicina 2000;60 Suppl 2():41-7.