Franz Worek

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Wille T; Tenberken O; Reiter G; Müller S; Le Provost R; Lafont O; Estour F; Thiermann H; Worek F
Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay.
Artursson Elisabet; Akfur Christine; Hörnberg Andreas; Worek Franz; Ekström Fredrik
Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis.
Thiermann Horst; Worek Franz; Eyer Peter; Eyer Florian; Felgenhauer Norbert; Zilker Thomas
Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships.

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2009: Wille T; Tenberken O; Reiter G; Müller S; Le Provost R; Lafont O; Estour F; Thiermann H; Worek F
Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay.
Toxicology 2009;265(3):96-100.
2009: Artursson Elisabet; Akfur Christine; Hörnberg Andreas; Worek Franz; Ekström Fredrik
Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis.
Toxicology 2009;265(3):108-14.
2009: Thiermann Horst; Worek Franz; Eyer Peter; Eyer Florian; Felgenhauer Norbert; Zilker Thomas
Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships.
Clinical toxicology (Philadelphia, Pa.) 2009;47(8):807-13.
2009: Eyer Florian; Worek Franz; Eyer Peter; Felgenhauer Norbert; Haberkorn Mike; Zilker Thomas; Thiermann Horst
Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness.
Clinical toxicology (Philadelphia, Pa.) 2009;47(8):798-806.
2009: Eyer Florian; Roberts Darren M; Buckley Nicholas A; Eddleston Michael; Thiermann Horst; Worek Franz; Eyer Peter
Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF).
Biochemical pharmacology 2009;78(5):531-7.
2009: Carletti Eugénie; Aurbek Nadine; Gillon Emilie; Loiodice Mélanie; Nicolet Yvain; Fontecilla-Camps Juan-Carlos; Masson Patrick; Thiermann Horst; Nachon Florian; Worek Franz
Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.
The Biochemical journal 2009;421(1):97-106.
2009: Eddleston Michael; Eyer Peter; Worek Franz; Juszczak Edmund; Alder Nicola; Mohamed Fahim; Senarathna Lalith; Hittarage Ariyasena; Azher Shifa; Jeganathan K; Jayamanne Shaluka; von Meyer Ludwig; Dawson Andrew H; Sheriff Mohamed Hussain Rezvi; Buckley Nick A
Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial.
PLoS medicine 2009;6(6):e1000104.
2009: Worek F; Herkert N M; Koller M; Aurbek N; Thiermann H
Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study.
Toxicology letters 2009;187(2):119-23.
2009: Theirmann Horst; Worek Franz; Eyer Peter
Comments on "Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI 6".
Toxicology mechanisms and methods 2009;19(4):334; author reply 335.
2009: Aurbek N; Thiermann H; Eyer F; Eyer P; Worek F
Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
Toxicology 2009;259(3):133-9.
2009: Herkert Nadja M; Lallement Guy; Clarençon Didier; Thiermann Horst; Worek Franz
Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.
Toxicology 2009;258(2-3):79-83.
2008: Eyer Peter; Eddleston Michael; Thiermann Horst; Worek Franz; Buckley Nick A
Are we using the right dose? - a tale of mole and gram.
British journal of clinical pharmacology 2008;66(4):451-2.
2008: Reiter Georg; Mikler John; Hill Ira; Weatherby Kendal; Thiermann Horst; Worek Franz
Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;873(1):86-94.
2008: Maxwell Donald M; Koplovitz Irwin; Worek Franz; Sweeney Richard E
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
Toxicology and applied pharmacology 2008;231(2):157-64.
2008: Kehe K; Raithel K; Kreppel H; Jochum M; Worek F; Thiermann H
Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells.
Archives of toxicology 2008;82(7):461-70.
2008: Blum Marc-Michael; Timperley Christopher M; Williams Gareth R; Thiermann Horst; Worek Franz
Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.
Biochemistry 2008;47(18):5216-24.
2008: Eyer Peter; Radtke Maria; Worek Franz
Reactions of isodimethoate with human red cell acetylcholinesterase.
Biochemical pharmacology 2008;75(10):2045-53.
2008: John Harald; Worek Franz; Thiermann Horst
LC-MS-based procedures for monitoring of toxic organophosphorus compounds and verification of pesticide and nerve agent poisoning.
Analytical and bioanalytical chemistry 2008;391(1):97-116.
2008: Herkert Nadja M; Eckert Saskia; Eyer Peter; Bumm Rudolf; Weber Georg; Thiermann Horst; Worek Franz
Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors.
Toxicology 2008;246(2-3):188-92.
2008: Eckert Saskia; Eyer Peter; Melzer Marco; Thiermann H; Worek Franz
Effects of oximes on rate of decarbamylation of human red blood cell AChE measured with two different methods.
Biochemical pharmacology 2008;75(7):1561-6.
2008: Worek F; Aurbek N; Wetherell J; Pearce P; Mann T; Thiermann H
Inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds: pig versus minipig acetylcholinesterase.
Toxicology 2008;244(1):35-41.
2008: Eckert Saskia; Eyer Peter; Herkert Nadja; Bumm Rudolf; Weber Georg; Thiermann Horst; Worek Franz
Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.
Biochemical pharmacology 2008;75(3):698-703.
2007: Reiter Georg; Koller Marianne; Thiermann Horst; Dorandeu Frederic; Mikler John; Worek Franz
Development and application of procedures for the highly sensitive quantification of cyclosarin enantiomers in hemolysed swine blood samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;859(1):9-15.
2007: Stenzel J; Worek F; Eyer P
Preparation and characterization of dialkylphosphoryl-obidoxime conjugates, potent anticholinesterase derivatives that are quickly hydrolyzed by human paraoxonase (PON1192Q).
Biochemical pharmacology 2007;74(9):1390-400.
2007: Worek F; Aurbek N; Thiermann H
Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro.
Journal of applied toxicology : JAT 2007;27(6):582-8.
2007: Thiermann Horst; Kehe Kai; Steinritz Dirk; Mikler John; Hill Ira; Zilker Thomas; Eyer Peter; Worek Franz
Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds.
Arhiv za higijenu rada i toksikologiju 2007;58(3):359-66.
2007: Worek Franz; Aurbek Nadine; Koller Marianne; Becker Christian; Eyer Peter; Thiermann Horst
Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates.
Biochemical pharmacology 2007;73(11):1807-17.
2007: Becker G; Kawan A; Gutzeit D; Worek F; Szinicz L
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
Archives of toxicology 2007;81(6):415-20.
2007: Steinritz D; Emmler J; Hintz M; Worek F; Kreppel H; Szinicz L; Kehe K
Apoptosis in sulfur mustard treated A549 cell cultures.
Life sciences 2007;80(24-25):2199-201.
2007: Seeger T; Worek F; Szinicz L; Thiermann H
Reevaluation of indirect field stimulation technique to demonstrate oxime effectiveness in OP-poisoning in muscles in vitro.
Toxicology 2007;233(1-3):209-13.
2007: Thiermann H; Szinicz L; Eyer P; Felgenhauer N; Zilker T; Worek F
Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning.
Toxicology 2007;233(1-3):145-54.
2007: Eckert Saskia; Eyer Peter; Worek Franz
Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge.
Toxicology 2007;233(1-3):180-6.
2007: Dorandeu F; Mikler J R; Thiermann H; Tenn C; Davidson C; Sawyer T W; Lallement G; Worek F
Swine models in the design of more effective medical countermeasures against organophosphorus poisoning.
Toxicology 2007;233(1-3):128-44.
2007: Eyer Peter; Szinicz Ladislaus; Thiermann Horst; Worek Franz; Zilker Thomas
Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality.
Toxicology 2007;233(1-3):108-19.
2007: Szinicz Ladislaus; Worek Franz; Thiermann Horst; Kehe Kai; Eckert Saskia; Eyer Peter
Development of antidotes: problems and strategies.
Toxicology 2007;233(1-3):23-30.
2007: Bartling A; Worek F; Szinicz L; Thiermann H
Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.
Toxicology 2007;233(1-3):166-72.
2007: Aurbek N; Thiermann H; Szinicz L; Worek F
Evaluation of HI 6 treatment after percutaneous VR exposure by use of a kinetic-based dynamic computer model.
Toxicology 2007;233(1-3):173-9.
2007: Worek Franz; Eyer Peter; Szinicz Ladislaus; Thiermann Horst
Simulation of cholinesterase status at different scenarios of nerve agent exposure.
Toxicology 2007;233(1-3):155-65.
2007: Worek F; Eyer P; Aurbek N; Szinicz L; Thiermann H
Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis.
Toxicology and applied pharmacology 2007;219(2-3):226-34.
2006: Worek F; Eyer P
The liberation of thiocholine from acetylthiocholine (ASCh) by pralidoxime iodide (2=PAM) and other oximes (obidoxime and diacetylmonoxime).
Toxicology letters 2006;167(3):256-7; author reply 258.
2006: Eddleston M; Mohamed F; Davies J O J; Eyer P; Worek F; Sheriff M H R; Buckley N A
Respiratory failure in acute organophosphorus pesticide self-poisoning.
QJM : monthly journal of the Association of Physicians 2006;99(8):513-22.
2006: Eckert Saskia; Eyer Peter; Mückter Harald; Worek Franz
Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds.
Biochemical pharmacology 2006;72(3):344-57.
2006: Aurbek N; Thiermann H; Szinicz L; Eyer P; Worek F
Application of kinetic-based computer modelling to evaluate the efficacy of HI 6 in percutaneous VX poisoning.
Toxicology 2006;224(1-2):74-80.
2006: Eckert Saskia; Eyer Peter; Mückter Harald; Worek Franz
Development of a dynamic model for real-time determination of membrane-bound acetylcholinesterase activity upon perfusion with inhibitors and reactivators.
Biochemical pharmacology 2006;72(3):358-65.
2006: Aurbek N; Thiermann H; Szinicz L; Eyer P; Worek F
Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase.
Toxicology 2006;224(1-2):91-9.
2005: Worek Franz; Szinicz Ladislaus; Thiermann Horst
Estimation of oxime efficacy in nerve agent poisoning: a kinetic approach.
Chemico-biological interactions 2005;157-158():349-52.
2005: Thiermann Horst; Szinicz Ladislaus; Eyer Peter; Zilker Thomas; Worek Franz
Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning.
Chemico-biological interactions 2005;157-158():345-7.
2005: Worek Franz; Szinicz Ladislaus; Eyer Peter; Thiermann Horst
Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model.
Toxicology and applied pharmacology 2005;209(3):193-202.
2005: Bartling A; Thiermann H; Szinicz L; Worek F
Effect of metoclopramide and ranitidine on the inhibition of human AChE by VX in vitro.
Journal of applied toxicology : JAT 2005;25(6):568-71.
2005: Eddleston Michael; Eyer Peter; Worek Franz; Mohamed Fahim; Senarathna Lalith; von Meyer Ludwig; Juszczak Edmund; Hittarage Ariyasena; Azhar Shifa; Dissanayake Wasantha; Sheriff M H Rezvi; Szinicz Ladislaus; Dawson Andrew H; Buckley Nick A
Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study.
Lancet 2005;366(9495):1452-9.
2005: Worek Franz; Koller Marianne; Thiermann Horst; Szinicz Ladislaus
Diagnostic aspects of organophosphate poisoning.
Toxicology 2005;214(3):182-9.
2005: Thiermann Horst; Eyer Peter; Worek Franz; Szinicz Ladislaus
Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon.
Toxicology 2005;214(3):190-7.
2005: Kiderlen D; Eyer P; Worek F
Formation and disposition of diethylphosphoryl-obidoxime, a potent anticholinesterase that is hydrolyzed by human paraoxonase (PON1).
Biochemical pharmacology 2005;69(12):1853-67.
2004: Worek Franz; Thiermann Horst; Szinicz Ladislaus; Eyer Peter
Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes.
Biochemical pharmacology 2004;68(11):2237-48.
2004: Herkenhoff S; Szinicz L; Rastogi V K; Cheng T-C; DeFrank J J; Worek F
Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase.
Archives of toxicology 2004;78(6):338-43.
2004: Worek F; Thiermann H; Szinicz L
Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines.
Archives of toxicology 2004;78(4):212-7.
2003: Eyer Peter; Worek Franz; Kiderlen Daniela; Sinko Goran; Stuglin Anita; Simeon-Rudolf Vera; Reiner Elsa
Molar absorption coefficients for the reduced Ellman reagent: reassessment.
Analytical biochemistry 2003;312(2):224-7.
2003: Eyer Florian; Meischner Veronika; Kiderlen Daniela; Thiermann Horst; Worek Franz; Haberkorn Michael; Felgenhauer Norbert; Zilker Thomas; Eyer Peter
Human parathion poisoning. A toxicokinetic analysis.
Toxicological reviews 2003;22(3):143-63.
2002: Krummer S; Thiermann H; Worek F; Eyer P
Equipotent cholinesterase reactivation in vitro by the nerve agent antidotes HI 6 dichloride and HI 6 dimethanesulfonate.
Archives of toxicology 2002;76(10):589-95.
2002: Worek F; Reiter G; Eyer P; Szinicz L
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
Archives of toxicology 2002;76(9):523-9.
2000: Kiderlen D; Worek F; Klimmek R; Eyer P
The phosphoryl oxime-destroying activity of human plasma.
Archives of toxicology 2000;74(1):27-32.
2000: Worek F; Eyer P; Kiderlen D; Thiermann H; Szinicz L
Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase.
Archives of toxicology 2000;74(1):21-6.
2000: Felgenhauer N; Zilker T; Worek F; Eyer P
Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss.
Journal of toxicology. Clinical toxicology 2000;38(7):803-8.
1999: Worek F; Mast U; Kiderlen D; Diepold C; Eyer P
Improved determination of acetylcholinesterase activity in human whole blood.
Clinica chimica acta; international journal of clinical chemistry 1999;288(1-2):73-90.
1999: Thiermann H; Szinicz L; Eyer F; Worek F; Eyer P; Felgenhauer N; Zilker T
Modern strategies in therapy of organophosphate poisoning.
Toxicology letters 1999;107(1-3):233-9.
1999: Worek F; Diepold C; Eyer P
Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics.
Archives of toxicology 1999;73(1):7-14.
1998: Worek F; Eyer P; Szinicz L
Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases.
Archives of toxicology 1998;72(9):580-7.
1998: Worek F; Widmann R; Knopff O; Szinicz L
Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds.
Archives of toxicology 1998;72(4):237-43.
1997: Worek F; Bäcker M; Thiermann H; Szinicz L; Mast U; Klimmek R; Eyer P
Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning.
Human & experimental toxicology 1997;16(8):466-72.
1997: Zilker T; Felgenhauer N; Hibler A; Pfab R; Thiermann H; Worek F; Eyer P
Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning.
Przegla¸d lekarski 1997;54(10):662-4.
1996: Worek F; Kirchner T; Bäcker M; Szinicz L
Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds.
Archives of toxicology 1996;70(8):497-503.
1995: Worek F; Kleine A; Szinicz L
Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning.
Human & experimental toxicology 1995;14(8):634-42.
1995: Worek F; Kleine A; Falke K; Szinicz L
Arrhythmias in organophosphate poisoning: effect of atropine and bispyridinium oximes.
Archives internationales de pharmacodynamie et de thérapie 1995;329(3):418-35.
1995: Worek F; Klimmek R; Szinicz L
Effects of atropine and soman on the pharmacokinetics of the oxime HLö 7 dimethanesulfonate in anesthetized guinea-pigs.
Drug and chemical toxicology 1995;18(2-3):137-49.
1995: Worek F; Kirchner T; Szinicz L
Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin.
Toxicology 1995;95(1-3):123-33.
1995: Worek F; Szinicz L
Cardiorespiratory function in nerve agent poisoned and oxime + atropine treated guinea-pigs: effect of pyridostigmine pretreatment.
Archives of toxicology 1995;69(5):322-9.
1994: Worek F; Kirchner T; Szinicz L
Effect of atropine, HLö 7 and HI 6 on respiratory and circulatory function in guinea-pigs poisoned by O-ethyl S-[2-(diisopropylamino) ethyl] methylphosponothioate (VX).
Pharmacology & toxicology 1994;75(5):302-9.
1994: Worek F; Kirchner T; Szinicz L
Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory function.
Archives of toxicology 1994;68(4):231-9.
1993: Worek F; Szinicz L
Analysis of cardiovascular and respiratory effects of various doses of soman in guinea-pigs: efficacy of atropine treatment.
Archives internationales de pharmacodynamie et de thérapie 1993;325():96-112.
1993: Worek F; Szinicz L
Investigation of acute cardiovascular and respiratory toxicity of HLö 7 dimethanesulfonate and HI 6 dichloride in anaesthetized guinea-pigs.
Pharmacology & toxicology 1993;73(2):91-5.
1993: Worek F; Szinicz L
Atropine and oxime treatment in lethal soman poisoning of anaesthetized guinea-pigs: HLö 7 dimethanesulfonate versus HI 6 dichloride.
Pharmacology & toxicology 1993;72(1):13-21.
1992: Eyer P; Hagedorn I; Klimmek R; Lippstreu P; Löffler M; Oldiges H; Spöhrer U; Steidl I; Szinicz L; Worek F
HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases.
Archives of toxicology 1992;66(9):603-21.

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