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Howard Worman

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Gregg G Gundersen; Howard J Worman
Nuclear positioning.
Jason C Choi; Howard J Worman
Reactivation of autophagy ameliorates LMNA cardiomyopathy.
Carolina Duarte-Rey; Juan-Manuel Anaya; DIMITRIOS BOGDANOS; Patrick S C Leung; Krista Roberts; Howard J Worman; Chen-Yen Yang; M Eric Gershwin
Primary biliary cirrhosis and the nuclear pore complex.

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All Publications

2013: Gregg G Gundersen; Howard J Worman
Nuclear positioning.
Cell 2013;152(6):1376-89.
2013: Jason C Choi; Howard J Worman
Reactivation of autophagy ameliorates LMNA cardiomyopathy.
Autophagy 2013;9(1):110-1.
2012: Carolina Duarte-Rey; Juan-Manuel Anaya; DIMITRIOS BOGDANOS; Patrick S C Leung; Krista Roberts; Howard J Worman; Chen-Yen Yang; M Eric Gershwin
Primary biliary cirrhosis and the nuclear pore complex.
Autoimmunity reviews 2012;11(12):898-902.
2012: Yuexia Wang; Jason C Choi; Gregg G Gundersen; Theresa C Swayne; Cecilia Ostlund; Howard J Worman
Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins.
Nucleus (Austin, Tex.) 2012;3(5):452-62.
2012: Jason C Choi; Shunichi Homma; Shinichi Iwata; John P Morrow; Antoine Muchir; Wei Wu; Howard J Worman
Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation.
Science translational medicine 2012;4(144):144ra102.
2012: Iván Méndez-López; Howard J Worman
Inner nuclear membrane proteins: impact on human disease.
Chromosoma 2012;121(2):153-67.
2012: Antoine Muchir; Sarah A Reilly; Gisèle Bonne; Shunichi Homma; Shinichi Iwata; Wei Wu; Howard J Worman
Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene.
Cardiovascular research 2012;93(2):311-9.
2012: Howard J Worman
Nuclear lamins and laminopathies.
The Journal of pathology 2012;226(2):316-25.
2011: Isabelle Duband-Goulet; Sylvaine Gasparini; Aurélie Gombault; Emilie Kondé; Cecilia Ostlund; Pascal Roussel; Carine Tellier-Lebègue; Nathalie Vadrot; Patrick Vicart; Stephanie Woerner; Howard J Worman; Sophie Zinn-Justin; Wikayatou Attanda; Constantin T Craescu; Brigitte Buendia
Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins.
Experimental cell research 2011;317(20):2800-13.
2011: Jonathan T Lu; Antoine Muchir; Peter L Nagy; Howard J Worman
LMNA cardiomyopathy: cell biology and genetics meet clinical medicine.
Disease models & mechanisms 2011;4(5):562-8.
2011: Guanghua Rong; Howard J Worman; Chen-Yen Yang; Guo-Xiang Yang; Renqian Zhong; Aftab A Ansari; Christopher L Bowlus; Ross L Coppel; Dean A Cuebas; Gregory J Gores; Xiaosong He; Pietro Invernizzi; Patrick S C Leung; Ana Lleo; Gary Norman; M Eric Gershwin
Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2011;54(1):196-203.
2011: G W Gant Luxton; Howard J Worman; Eric S Folker; Edgar R Gomes; Gregg G Gundersen
TAN lines: a novel nuclear envelope structure involved in nuclear positioning.
Nucleus (Austin, Tex.) 2011;2(3):173-81.
2011: Wei Wu; Antoine Muchir; Jian Shan; Gisèle Bonne; Howard J Worman
Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene.
Circulation 2011;123(1):53-61.
2011: Eric S Folker; Cecilia Ostlund; G W Gant Luxton; Howard J Worman; Gregg G Gundersen
Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):131-6.
2010: Haiying Liu; Gary L Norman; Zakera Shums; Howard J Worman; Edward L Krawitt; Nicola Bizzaro; Diego Vergani; Dimitrios P Bogdanos; George N Dalekos; Piotr Milkiewicz; Albert J Czaja; E Jenny Heathcote; Gideon M Hirschfield; Eng M Tan; Kiyomitsu Miyachi; Monica Bignotto; Pier Maria Battezzati; Ana Lleo; Patrick S C Leung; Mauro Podda; M Eric Gershwin; Pietro Invernizzi
PBC screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis.
Journal of autoimmunity 2010;35(4):436-42.
2010: Antoine Muchir; Wei Wu; Howard J Worman
Mitogen-activated protein kinase inhibitor regulation of heart function and fibrosis in cardiomyopathy caused by lamin A/C gene mutation.
Trends in cardiovascular medicine 2010;20(7):217-21.
2010: Emilie Kondé; Benjamin Bourgeois; Carine Tellier-Lebegue; Wei Wu; Javier Pérez; Sandrine Caputo; Wika Attanda; Sylvaine Gasparini; Jean-Baptiste Charbonnier; Bernard Gilquin; Howard J Worman; Sophie Zinn-Justin
Structural analysis of the Smad2-MAN1 interaction that regulates transforming growth factor-β signaling at the inner nuclear membrane.
Biochemistry 2010;49(37):8020-32.
2010: Antoine Muchir; Howard J Worman
Signaling defects and the nuclear envelope in progeria.
Developmental cell 2010;19(3):355-6.
2010: Yuexia Wang; Cecilia Ostlund; Howard J Worman
Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome.
Nucleus (Austin, Tex.) 2010;1(5):432-9.
2010: Ana Lleo; Christopher L Bowlus; Guo-Xiang Yang; Pietro Invernizzi; Mauro Podda; Judith A van de Water; Aftab A Ansari; Ross L Coppel; Howard J Worman; Gregory J Gores; M Eric Gershwin
Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2010;52(3):987-98.
2010: Francine Bruston; Erwan Delbarre; Cecilia Ostlund; Howard J Worman; Brigitte Buendia; Isabelle Duband-Goulet
Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin.
FEBS letters 2010;584(14):2999-3004.
2010: Wei Wu; Jian Shan; Gisèle Bonne; Howard J Worman; Antoine Muchir
Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene.
Biochimica et biophysica acta 2010;1802(7-8):632-8.
2010: Angelika Lüdtke; G M Roos; M van Hettinga; B A J Horst; Howard J Worman; Hartmut H-J Schmidt
Post-mortem findings in Dunnigan-type familial partial lipodystrophy.
Diabetic medicine : a journal of the British Diabetic Association 2010;27(2):245-6.
2010: Howard J Worman; Cecilia Ostlund; Yuexia Wang
Diseases of the nuclear envelope.
Cold Spring Harbor perspectives in biology 2010;2(2):a000760.
2010: Howard J Worman; Roland Foisner
The nuclear envelope from basic biology to therapy.
Biochemical Society transactions 2010;38(Pt 1):253-6.
2010: Howard J Worman
Prelamin A prenylation and the treatment of progeria.
Journal of lipid research 2010;51(2):223-5.
2009: Cecilia Ostlund; Eric S Folker; Jason C Choi; Edgar R Gomes; Gregg G Gundersen; Howard J Worman
Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins.
Journal of cell science 2009;122(Pt 22):4099-108.
2009: Cecilia Ostlund; Tinglu Guan; Denise A Figlewicz; Arthur P Hays; Howard J Worman; Larry Gerace; Eric C Schirmer
Reduction of a 4q35-encoded nuclear envelope protein in muscle differentiation.
Biochemical and biophysical research communications 2009;389(2):279-83.
2009: Howard J Worman; Loren G Fong; Antoine Muchir; Stephen G Young
Laminopathies and the long strange trip from basic cell biology to therapy.
The Journal of clinical investigation 2009;119(7):1825-36.
2009: Valerie L R M Verstraeten; Sandrine Caputo; Maurice A M van Steensel; Isabelle Duband-Goulet; Sophie Zinn-Justin; Miriam Kamps; Helma J H Kuijpers; Cecilia Ostlund; Howard J Worman; Jacob J Briedé; Caroline Le Dour; Carlo L M Marcelis; Michel van Geel; Peter M Steijlen; Arthur van den Wijngaard; Frans C S Ramaekers; Jos L V Broers
The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress.
Journal of cellular and molecular medicine 2009;13(5):959-71.
2009: Antoine Muchir; Wei Wu; Howard J Worman
Reduced expression of A-type lamins and emerin activates extracellular signal-regulated kinase in cultured cells.
Biochimica et biophysica acta 2009;1792(1):75-81.
2008: Yuexia Wang; Andrey Panteleyev; David M Owens; Karima Djabali; Colin L Stewart; Howard J Worman
Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin.
Human molecular genetics 2008;17(15):2357-69.
2008: Howard J Worman
Diagnosis and treatment of chronic hepatitis C in incarcerated patients.
The virtual mentor : VM 2008;10(2):102-5.
2007: Carlo Selmi; M Eric Gershwin; Keith D Lindor; Howard J Worman; Ellen B Gold; Mitchell Watnik; Jessica Utts; Pietro Invernizzi; Marshall M Kaplan; John M Vierling; Christopher L Bowlus; Marina G Silveira; Ilaria Bossi
Quality of life and everyday activities in patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2007;46(6):1836-43.
2007: Howard J Worman
Nuclear envelope protein autoantigens in primary biliary cirrhosis.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37 Suppl 3():S406-11.
2007: Howard J Worman
Re-evaluating the use of growth factors as adjuvant treatment of chronic hepatitis C.
Hepatology (Baltimore, Md.) 2007;46(4):1307-8; author reply 1307-8.
2007: Angelika Lüdtke; Janine Buettner; Hartmut H-J Schmidt; Howard J Worman
New PPARG mutation leads to lipodystrophy and loss of protein function that is partially restored by a synthetic ligand.
Journal of medical genetics 2007;44(9):e88.
2007: Antoine Muchir; Paul Pavlidis; Gisèle Bonne; Yukiko K Hayashi; Howard J Worman
Activation of MAPK in hearts of EMD null mice: similarities between mouse models of X-linked and autosomal dominant Emery Dreifuss muscular dystrophy.
Human molecular genetics 2007;16(15):1884-95.
2007: Howard J Worman; Gisèle Bonne
"Laminopathies": a wide spectrum of human diseases.
Experimental cell research 2007;313(10):2121-33.
2007: Angelika Lüdtke; Janine Buettner; Wei Wu; Antoine Muchir; Andreas Schroeter; Sophie Zinn-Justin; Simone Spuler; Hartmut H-J Schmidt; Howard J Worman
Peroxisome proliferator-activated receptor-gamma C190S mutation causes partial lipodystrophy.
The Journal of clinical endocrinology and metabolism 2007;92(6):2248-55.
2007: Antoine Muchir; Paul Pavlidis; Valérie Decostre; Alan J Herron; Takuro Arimura; Gisèle Bonne; Howard J Worman
Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy.
The Journal of clinical investigation 2007;117(5):1282-93.
2007: Antoine Muchir; Howard J Worman
Emery-Dreifuss muscular dystrophy.
Current neurology and neuroscience reports 2007;7(1):78-83.
2006: Antoine Muchir; Catherine Massart; B G M van Engelen; Martin Lammens; Gisèle Bonne; Howard J Worman
Proteasome-mediated degradation of integral inner nuclear membrane protein emerin in fibroblasts lacking A-type lamins.
Biochemical and biophysical research communications 2006;351(4):1011-7.
2006: Yuexia Wang; Alan J Herron; Howard J Worman
Pathology and nuclear abnormalities in hearts of transgenic mice expressing M371K lamin A encoded by an LMNA mutation causing Emery-Dreifuss muscular dystrophy.
Human molecular genetics 2006;15(16):2479-89.
2006: Sandrine Caputo; Joël Couprie; Isabelle Duband-Goulet; Emilie Kondé; Feng Lin; Sandrine Braud; Muriel Gondry; Bernard Gilquin; Howard J Worman; Sophie Zinn-Justin
The carboxyl-terminal nucleoplasmic region of MAN1 exhibits a DNA binding winged helix domain.
The Journal of biological chemistry 2006;281(26):18208-15.
2006: Józefa Wesierska-Gadek; Edward Penner; Pier Maria Battezzati; Carlo Selmi; Massimo Zuin; Eva Hitchman; Howard J Worman; M Eric Gershwin; Mauro Podda; Pietro Invernizzi
Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2006;43(5):1135-44.
2006: Howard J Worman
Inner nuclear membrane and regulation of Smad-mediated signaling.
Biochimica et biophysica acta 2006;1761(5-6):626-31.
2006: Revekka L Boguslavsky; Colin L Stewart; Howard J Worman
Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy.
Human molecular genetics 2006;15(4):653-63.
2006: Cecilia Ostlund; Teresa Sullivan; Colin L Stewart; Howard J Worman
Dependence of diffusional mobility of integral inner nuclear membrane proteins on A-type lamins.
Biochemistry 2006;45(5):1374-82.
2006: Howard J Worman; Gregg G Gundersen
Here come the SUNs: a nucleocytoskeletal missing link.
Trends in cell biology 2006;16(2):67-9.
2006: Sandrine Caputo; Feng Lin; Bernard Gilquin; Howard J Worman; Sophie Zinn-Justin; Joël Couprie
NMR assignment of region 655-775 of human MAN1.
Journal of biomolecular NMR 2006;36 Suppl 1():2.
2005: Howard J Worman
Inner nuclear membrane and signal transduction.
Journal of cellular biochemistry 2005;96(6):1185-92.
2005: M Eric Gershwin; Carlo Selmi; Howard J Worman; Ellen B Gold; Mitchell Watnik; Jessica Utts; Keith D Lindor; Marshall M Kaplan; John M Vierling
Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients.
Hepatology (Baltimore, Md.) 2005;42(5):1194-202.
2005: Angelika Lüdtke; K Heck; Janine Genschel; H Mehnert; Simone Spuler; Howard J Worman; Hartmut H-J Schmidt
Long-term treatment experience in a subject with Dunnigan-type familial partial lipodystrophy: efficacy of rosiglitazone.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(11):1611-3.
2005: Angelika Lüdtke; Janine Genschel; Georg Brabant; Juergen Bauditz; Matthias Taupitz; Martin Koch; Wolfram Wermke; Howard J Worman; Hartmut H-J Schmidt
Hepatic steatosis in Dunnigan-type familial partial lipodystrophy.
The American journal of gastroenterology 2005;100(10):2218-24.
2005: Jos L V Broers; Helma J H Kuijpers; Cecilia Ostlund; Howard J Worman; Jorike Endert; Frans C S Ramaekers
Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization.
Experimental cell research 2005;304(2):582-92.
2005: Cecilia Ostlund; Ruth M Garcia-Carrasquillo; Alexandra Belayew; Howard J Worman
Intracellular trafficking and dynamics of double homeodomain proteins.
Biochemistry 2005;44(7):2378-84.
2005: Feng Lin; Juliet M Morrison; Wei Wu; Howard J Worman
MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling.
Human molecular genetics 2005;14(3):437-45.
2005: Howard J Worman
Approach to the patient with alcoholic liver disease.
The virtual mentor : VM 2005;7(9):.
2005: Howard J Worman; Jean-Claude Courvalin
Nuclear envelope, nuclear lamina, and inherited disease.
International review of cytology 2005;246():231-79.
2005: Mauro Paradisi; Dayle McClintock; Revekka L Boguslavsky; Cristina Pedicelli; Howard J Worman; Karima Djabali
Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress.
BMC cell biology 2005;6():27.
2005: Howard J Worman
Components of the nuclear envelope and their role in human disease.
Novartis Foundation symposium 2005;264():35-42; discussion 42-50, 227-30.
2004: Susan Gilchrist; Nick Gilbert; Paul Perry; Cecilia Ostlund; Howard J Worman; Wendy A Bickmore
Altered protein dynamics of disease-associated lamin A mutants.
BMC cell biology 2004;5(1):46.
2004: Christopher J Hutchison; Howard J Worman
A-type lamins: guardians of the soma?
Nature cell biology 2004;6(11):1062-7.
2004: Nora V Bergasa; Andrew Mason; Annarosa Floreani; Jenny Heathcote; Mark G Swain; David E J Jones; Keith M Lindor; Margaret F Bassendine; Howard J Worman
Primary biliary cirrhosis: report of a focus study group.
Hepatology (Baltimore, Md.) 2004;40(4):1013-20.
2004: Antoine Muchir; Howard J Worman
The nuclear envelope and human disease.
Physiology (Bethesda, Md.) 2004;19():309-14.
2004: Antoine Muchir; Jacques Medioni; M Laluc; Catherine Massart; Takuro Arimura; Anneke J van der Kooi; Isabelle Desguerre; M Mayer; Xavier Ferrer; Sylvain Briault; M Hirano; Howard J Worman; Alain Mallet; Manfred Wehnert; Ketty Schwartz; Gisèle Bonne
Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations.
Muscle & nerve 2004;30(4):444-50.
2004: Elizabeth C Verna; Alberto Larghi; Sami G Faddoul; Jeffrey A Stein; Howard J Worman
Portal vein thrombosis associated with Fusobacterium nucleatum septicemia in a patient with ulcerative colitis.
Journal of clinical gastroenterology 2004;38(7):611-2.
2004: Howard J Worman; Jean-Claude Courvalin
How do mutations in lamins A and C cause disease?
The Journal of clinical investigation 2004;113(3):349-51.
2004: Cecilia Ostlund; Howard J Worman
Lamin-associated proteins.
Methods in cell biology 2004;78():829-59.
2004: Howard J Worman
Nuclear envelope proteins and human disease.
Symposia of the Society for Experimental Biology 2004;(56):41-55.
2003: Girdhar G Sharma; Kyu-Kye Hwang; Raj K Pandita; Arun Gupta; Sonu Dhar; Julie Parenteau; Manjula Agarwal; Howard J Worman; Raymund J Wellinger; Tej K Pandita
Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation.
Molecular and cellular biology 2003;23(22):8363-76.
2003: Ian Holt; Cecilia Ostlund; Colin L Stewart; Nguyen thi Man; Howard J Worman; Glenn E Morris
Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo.
Journal of cell science 2003;116(Pt 14):3027-35.
2003: Howard J Worman; Jean-Claude Courvalin
Antinuclear antibodies specific for primary biliary cirrhosis.
Autoimmunity reviews 2003;2(4):211-7.
2003: Shinji Shimoda; Minoru Nakamura; Hiromi Ishibashi; Akira Kawano; Takashi Kamihira; Norihiro Sakamoto; Sho Matsushita; Atsushi Tanaka; Howard J Worman; M Eric Gershwin; Mine Harada
Molecular mimicry of mitochondrial and nuclear autoantigens in primary biliary cirrhosis.
Gastroenterology 2003;124(7):1915-25.
2003: Vérène Stierlé; Joël Couprie; Cecilia Ostlund; Isabelle Krimm; Sophie Zinn-Justin; Paul Hossenlopp; Howard J Worman; Jean-Claude Courvalin; Isabelle Duband-Goulet
The carboxyl-terminal region common to lamins A and C contains a DNA binding domain.
Biochemistry 2003;42(17):4819-28.
2003: Cecilia Ostlund; Howard J Worman
Nuclear envelope proteins and neuromuscular diseases.
Muscle & nerve 2003;27(4):393-406.
2003: Alberto Larghi; Daniel Leffler; Harold Frucht; Moshe Rubin; Carol E Semrad; Jay H Lefkowitch; Howard J Worman
Hepatitis B virus reactivation after kidney transplantation and new onset lymphoma.
Journal of clinical gastroenterology 2003;36(3):276-80.
2003: Catherine Favreau; Emmanuelle Dubosclard; Cecilia Ostlund; Corinne Vigouroux; Jacqueline Capeau; Manfred Wehnert; Dominique Higuet; Howard J Worman; Jean-Claude Courvalin; Brigitte Buendia
Expression of lamin A mutated in the carboxyl-terminal tail generates an aberrant nuclear phenotype similar to that observed in cells from patients with Dunnigan-type partial lipodystrophy and Emery-Dreifuss muscular dystrophy.
Experimental cell research 2003;282(1):14-23.
2002: Howard J Worman; Jean-Claude Courvalin
The nuclear lamina and inherited disease.
Trends in cell biology 2002;12(12):591-8.
2002: Arti Parikh-Patel; Ellen B Gold; Jessica Utts; Howard J Worman; Kathryn E Krivy; M Eric Gershwin
Functional status of patients with primary biliary cirrhosis.
The American journal of gastroenterology 2002;97(11):2871-9.
2002: Isabelle Krimm; Cecilia Ostlund; Bernard Gilquin; Joël Couprie; Paul Hossenlopp; Jean-Paul Mornon; Gisèle Bonne; Jean-Claude Courvalin; Howard J Worman; Sophie Zinn-Justin
The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy.
Structure (London, England : 1993) 2002;10(6):811-23.
2002: Kyu-Kye Hwang; Howard J Worman
Gene regulation by human orthologs of Drosophila heterochromatin protein 1.
Biochemical and biophysical research communications 2002;293(4):1217-22.
2002: Robert M Dettmer; John F Reinus; David Clain; Ayse Aytaman; Hulya Levendoglu; Alan Bloom; Mary P Isaacson; Mitchel Spinnell; Douglas Meyer; Viyada Sarabanchong; Yatian Zhang; Reuben J Garcia-Carrasquillo; David D Markowitz; Arthur M Magun; Howard J Worman
Interferon-alpha-2b and ribavirin for retreatment of chronic hepatitis C.
Hepato-gastroenterology 2002;49(45):758-63.
2002: Isabelle Krimm; Joël Couprie; Cecilia Ostlund; Howard J Worman; Sophie Zinn-Justin
1H, 13C and 15N resonance assignments of the C-terminal domain of human lamin A/C.
Journal of biomolecular NMR 2002;22(4):371-2.
2002: Wei Wu; Feng Lin; Howard J Worman
Intracellular trafficking of MAN1, an integral protein of the nuclear envelope inner membrane.
Journal of cell science 2002;115(Pt 7):1361-71.
2002: Gisèle Bonne; Jaqueline Capeau; Marianne De Visser; Denis Duboc; Luciano Merlini; Glenn E Morris; Francesco Muntoni; Dominique Recan; Caroline Sewry; Stefano Squarzoni; Colin Stewart; Beril Talim; Anneke J van der Kooi; Howard J Worman; Ketty Schwartz
82nd ENMC international workshop, 5th international Emery-Dreifuss muscular dystrophy (EDMD) workshop, 1st Workshop of the MYO-CLUSTER project EUROMEN (European muscle envelope nucleopathies), 15-16 September 2000, Naarden, The Netherlands.
Neuromuscular disorders : NMD 2002;12(2):187-94.
2001: Cecilia Ostlund; Gisèle Bonne; K Schwartz; Howard J Worman
Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy.
Journal of cell science 2001;114(Pt 24):4435-45.
2001: L Holmer; Howard J Worman
Inner nuclear membrane proteins: functions and targeting.
Cellular and molecular life sciences : CMLS 2001;58(12-13):1741-7.
2001: Birgit Terjung; Howard J Worman; Volker Herzog; T Sauerbruch; Ulrich Spengler
Differentiation of antineutrophil nuclear antibodies in inflammatory bowel and autoimmune liver diseases from antineutrophil cytoplasmic antibodies (p-ANCA) using immunofluorescence microscopy.
Clinical and experimental immunology 2001;126(1):37-46.
2001: Kyu-Kye Hwang; Joel C Eissenberg; Howard J Worman
Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11423-7.
2001: Birgit Terjung; Howard J Worman
Anti-neutrophil antibodies in primary sclerosing cholangitis.
Best practice & research. Clinical gastroenterology 2001;15(4):629-42.
2001: C Laguri; Bernard Gilquin; Nicolas Wolff; Régine Romi-Lebrun; K Courchay; Isabelle Callebaut; Howard J Worman; Sophie Zinn-Justin
Structural characterization of the LEM motif common to three human inner nuclear membrane proteins.
Structure (London, England : 1993) 2001;9(6):503-11.
2001: Katherine L Wilson; Ricardo Benavente; B Burke; R Craigie; Roland Foisner; K Furukawa; L Gerace; R D Goldman; Y Gruenbaum; C Harris; Christopher J Hutchison; Georg Krohne; G E Morris; Henning Otto; A J Simon; Howard J Worman
Problems with LAP nomenclature.
Nature cell biology 2001;3(4):E90.
2001: J Ma; Kyu-Kye Hwang; Howard J Worman; Jean-Claude Courvalin; Joel C Eissenberg
Expression and functional analysis of three isoforms of human heterochromatin-associated protein HP1 in Drosophila.
Chromosoma 2001;109(8):536-44.
2001: Arti Parikh-Patel; Ellen B Gold; Howard J Worman; K E Krivy; M Eric Gershwin
Risk factors for primary biliary cirrhosis in a cohort of patients from the united states.
Hepatology (Baltimore, Md.) 2001;33(1):16-21.
2000: Howard J Worman; Jean-Claude Courvalin
The inner nuclear membrane.
The Journal of membrane biology 2000;177(1):1-11.
2000: Birgit Terjung; Ulrich Spengler; T Sauerbruch; Howard J Worman
"Atypical p-ANCA" in IBD and hepatobiliary disorders react with a 50-kilodalton nuclear envelope protein of neutrophils and myeloid cell lines.
Gastroenterology 2000;119(2):310-22.
2000: Feng Lin; D L Blake; I Callebaut; Ilona Skerjanc; L Holmer; M W McBurney; M Paulin-Levasseur; Howard J Worman
MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin.
The Journal of biological chemistry 2000;275(7):4840-7.
1999: R M Barton; Howard J Worman
Prenylated prelamin A interacts with Narf, a novel nuclear protein.
The Journal of biological chemistry 1999;274(42):30008-18.
1999: E Minc; Y Allory; Howard J Worman; Jean-Claude Courvalin; Brigitte Buendia
Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells.
Chromosoma 1999;108(4):220-34.
1999: Cecilia Ostlund; Jan Ellenberg; Einar Hallberg; Jennifer Lippincott-Schwartz; Howard J Worman
Intracellular trafficking of emerin, the Emery-Dreifuss muscular dystrophy protein.
Journal of cell science 1999;112 ( Pt 11)():1709-19.
1999: N Mamiya; Howard J Worman
Hepatitis C virus core protein binds to a DEAD box RNA helicase.
The Journal of biological chemistry 1999;274(22):15751-6.
1999: Stefano Quaranta; Howard M Shulman; Alaa Ahmed; Yehuda Shoenfeld; J Peter; G B McDonald; Judith A van de Water; Ross Coppel; Cecilia Ostlund; Howard J Worman; Mario Rizzetto; Koichi tsuneyama; Yasuni Nakanuma; Aftab A Ansari; F Locatelli; S Paganin; Floriano Rosina; M Manns; M Eric Gershwin
Autoantibodies in human chronic graft-versus-host disease after hematopoietic cell transplantation.
Clinical immunology (Orlando, Fla.) 1999;91(1):106-16.
1998: L Holmer; A Pezhman; Howard J Worman
The human lamin B receptor/sterol reductase multigene family.
Genomics 1998;54(3):469-76.
1998: A Park; L Holmer; Howard J Worman
A human HP1 pseudogene maps to chromosome 11p14.
Somatic cell and molecular genetics 1998;24(6):353-6.
1998: E De La Riva; Reuben J Garcia-Carrasquillo; M D Puppo; P J Mustacchia; S Factor; A Joe; J Finegold; T H Riley; V Sarabanchong; RJ Ligresti; D D Markowitz; D J McMahon; Arthur M Magun; Howard J Worman
Escalating interferon-alpha-2b dose for patients with chronic hepatitis C.
Hepato-gastroenterology 1998;45(24):2308-14.
1998: Birgit Terjung; Volker Herzog; Howard J Worman; Ingo Gestmann; C Bauer; Tilman Sauerbruch; Ulrich Spengler
Atypical antineutrophil cytoplasmic antibodies with perinuclear fluorescence in chronic inflammatory bowel diseases and hepatobiliary disorders colocalize with nuclear lamina proteins.
Hepatology (Baltimore, Md.) 1998;28(2):332-40.
1998: Q Ye; R M Barton; Howard J Worman
Nuclear lamin-binding proteins.
Sub-cellular biochemistry 1998;31():587-610.
1997: F Lin; Howard J Worman
Expression of nuclear lamins in human tissues and cancer cell lines and transcription from the promoters of the lamin A/C and B1 genes.
Experimental cell research 1997;236(2):378-84.
1997: A Mattalia; B Lüttig; Floriano Rosina; Patrick S C Leung; Judith A van de Water; M Bauducci; A Ciancio; K H Böker; Howard J Worman; R L Cooper; M Manns; Aftab A Ansari; Mario Rizzetto; M Eric Gershwin
Persistence of autoantibodies against recombinant mitochondrial and nuclear pore proteins after orthotopic liver transplantation for primary biliary cirrhosis.
Journal of autoimmunity 1997;10(5):491-7.
1997: Isabelle Callebaut; Jean-Claude Courvalin; Howard J Worman; Jean-Paul Mornon
Hydrophobic cluster analysis reveals a third chromodomain in the Tetrahymena Pdd1p protein of the chromo superfamily.
Biochemical and biophysical research communications 1997;235(1):103-7.
1997: Q Ye; I Callebaut; A Pezhman; Jean-Claude Courvalin; Howard J Worman
Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR.
The Journal of biological chemistry 1997;272(23):14983-9.
1997: A Nishio; Judith A van de Water; Patrick S C Leung; Ruth E Joplin; James M Neuberger; J Lake; A Björkland; Thomas H Tötterman; M Peters; Howard J Worman; Aftab A Ansari; Ross Coppel; M Eric Gershwin
Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 1997;25(5):1085-9.
1997: Jean-Claude Courvalin; Howard J Worman
Nuclear envelope protein autoantibodies in primary biliary cirrhosis.
Seminars in liver disease 1997;17(1):79-90.
1996: Q Ye; Howard J Worman
Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1.
The Journal of biological chemistry 1996;271(25):14653-6.
1996: C Favreau; Howard J Worman; Richard W Wozniak; T Frappier; Jean-Claude Courvalin
Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210.
Biochemistry 1996;35(24):8035-44.
1996: F Lin; C M Noyer; Q Ye; Jean-Claude Courvalin; Howard J Worman
Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR.
Hepatology (Baltimore, Md.) 1996;23(1):57-61.
1995: B Soullam; Howard J Worman
Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane.
The Journal of cell biology 1995;130(1):15-27.
1995: Q Ye; Howard J Worman
Protein-protein interactions between human nuclear lamins expressed in yeast.
Experimental cell research 1995;219(1):292-8.
1995: F Lin; Howard J Worman
Structural organization of the human gene (LMNB1) encoding nuclear lamin B1.
Genomics 1995;27(2):230-6.
1995: F Tartakovsky; Howard J Worman
Detection of Gp210 autoantibodies in primary biliary cirrhosis using a recombinant protein containing the predominant autoepitope.
Hepatology (Baltimore, Md.) 1995;21(2):495-500.
1994: Howard J Worman
Primary biliary cirrhosis and the molecular cell biology of the nuclear envelope.
The Mount Sinai journal of medicine, New York 1994;61(6):461-75.
1994: E Schuler; F Lin; Howard J Worman
Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane.
The Journal of biological chemistry 1994;269(15):11312-7.
1994: Q Ye; Howard J Worman
Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane.
The Journal of biological chemistry 1994;269(15):11306-11.
1994: R E Nickowitz; Richard W Wozniak; F Schaffner; Howard J Worman
Autoantibodies against integral membrane proteins of the nuclear envelope in patients with primary biliary cirrhosis.
Gastroenterology 1994;106(1):193-9.
1993: R E Nickowitz; Howard J Worman
Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the cytoplasmic tail of nuclear pore membrane glycoprotein Gp210.
The Journal of experimental medicine 1993;178(6):2237-42.
1993: F Lin; Howard J Worman
Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C.
The Journal of biological chemistry 1993;268(22):16321-6.
1993: B Soullam; Howard J Worman
The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal.
The Journal of cell biology 1993;120(5):1093-100.
1992: Jean-Claude Courvalin; N Segil; Günter Blobel; Howard J Worman
The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase.
The Journal of biological chemistry 1992;267(27):19035-8.
1992: Paul D Berk; Howard J Worman
An introduction to molecular biology and recombinant DNA technology for the hepatologist.
Seminars in liver disease 1992;12(3):227-45.
1991: Howard J Worman; Jean-Claude Courvalin
Autoantibodies against nuclear envelope proteins in liver disease.
Hepatology (Baltimore, Md.) 1991;14(6):1269-79.
1990: Howard J Worman
Cellular intermediate filament networks and their derangement in alcoholic hepatitis.
Alcoholism, clinical and experimental research 1990;14(6):789-804.
1990: Howard J Worman; C D Evans; Günter Blobel
The lamin B receptor of the nuclear envelope inner membrane: a polytopic protein with eight potential transmembrane domains.
The Journal of cell biology 1990;111(4):1535-42.
1990: Jean-Claude Courvalin; Kaiss Lassoued; Howard J Worman; Günter Blobel
Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis.
The Journal of experimental medicine 1990;172(3):961-7.
1988: Howard J Worman; J Yuan; Günter Blobel; Spyros D Georgatos
A lamin B receptor in the nuclear envelope.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8531-4.
1988: Howard J Worman; I Lazaridis; Spyros D Georgatos
Nuclear lamina heterogeneity in mammalian cells. Differential expression of the major lamins and variations in lamin B phosphorylation.
The Journal of biological chemistry 1988;263(24):12135-41.