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Walter Wouters

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F Tack; M Noppe; A Van Dijck; N Dekeyzer; B J Van Der Leede; A Bakker; Walter Wouters; M Janicot; M E Brewster
Delivery of a DNAzyme targeting c-myc to HT29 colon carcinoma cells using a gold nanoparticulate approach.
Patrick Angibaud; Laurence Mevellec; Christophe Meyer; Xavier Bourdrez; Patricia Lezouret; Isabelle Pilatte; Virginie Poncelet; Bruno Roux; Sophie Merillon; David W End; Jacky Van Dun; Walter Wouters; Marc Venet
Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra series.
Patrick Angibaud; Xavier Bourdrez; David W End; Eddy Freyne; Michel Janicot; Patricia Lezouret; Yannick Ligny; Geert Mannens; Siegrid Damsch; Laurence Mevellec; Christophe Meyer; Philippe Muller; Isabelle Pilatte; Virginie Poncelet; Bruno Roux; Gerda Smets; Jacky Van Dun; Pieter Van Remoortere; Marc Venet; Walter Wouters
Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.

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All Publications

2008: F Tack; M Noppe; A Van Dijck; N Dekeyzer; B J Van Der Leede; A Bakker; Walter Wouters; M Janicot; M E Brewster
Delivery of a DNAzyme targeting c-myc to HT29 colon carcinoma cells using a gold nanoparticulate approach.
Die Pharmazie 2008;63(3):221-5.
2007: Patrick Angibaud; Laurence Mevellec; Christophe Meyer; Xavier Bourdrez; Patricia Lezouret; Isabelle Pilatte; Virginie Poncelet; Bruno Roux; Sophie Merillon; David W End; Jacky Van Dun; Walter Wouters; Marc Venet
Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra series.
European journal of medicinal chemistry 2007;42(5):702-14.
2003: Patrick Angibaud; Xavier Bourdrez; David W End; Eddy Freyne; Michel Janicot; Patricia Lezouret; Yannick Ligny; Geert Mannens; Siegrid Damsch; Laurence Mevellec; Christophe Meyer; Philippe Muller; Isabelle Pilatte; Virginie Poncelet; Bruno Roux; Gerda Smets; Jacky Van Dun; Pieter Van Remoortere; Marc Venet; Walter Wouters
Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(24):4365-9.
2003: Patrick Angibaud; Ashis K Saha; Xavier Bourdrez; David W End; Eddy Freyne; Patricia Lezouret; Geert Mannens; Laurence Mevellec; Christophe Meyer; Isabelle Pilatte; Virginie Poncelet; Bruno Roux; Gerda Smets; Jacky Van Dun; Marc Venet; Walter Wouters
4-methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA.
Bioorganic & medicinal chemistry letters 2003;13(24):4361-4.
2003: Jodi A Laakso; Ursula M Mocek; Jacky Van Dun; Walter Wouters; Michel Janicot
R176502, a new bafilolide metabolite with potent antiproliferative activity from a novel Micromonospora species.
The Journal of antibiotics 2003;56(11):909-16.
2003: Yasumichi Hitoshi; Tarikere L Gururaja; Denise M Pearsall; Wayne Lang; Poonam Sharma; Betty Huang; Susan M Catalano; John McLaughlin; Erlina Pali; Beau Peelle; Jorge Vialard; Michel Janicot; Walter Wouters; Walter H M L Luyten; Mark K Bennett; Dave C Anderson; Donald G Payan; James B Lorens; Jakob Bogenberger; Susan D Demo
Cellular localization and antiproliferative effect of peptides discovered from a functional screen of a retrovirally delivered random peptide library.
Chemistry & biology 2003;10(10):975-87.
2003: Patrick Angibaud; Xavier Bourdrez; Ann Devine; David W End; Eddy Freyne; Yannick Ligny; Philippe Muller; Geert Mannens; Isabelle Pilatte; Virginie Poncelet; Stacy Skrzat; Gerda Smets; Jacky Van Dun; Pieter Van Remoortere; Marc Venet; Walter Wouters
5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(9):1543-7.
2003: William Gunning; Paula M Kramer; Ronald A Lubet; Vernon E Steele; David W End; Walter Wouters; Michael A Pereira
Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1927-30.
2003: Stefanie De Schepper; Hélène Bruwiere; Tinne Verhulst; Ulf Steller; Luc Andries; Walter Wouters; Michel Janicot; Janine Arts; Jim Van Heusden
Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin.
The Journal of pharmacology and experimental therapeutics 2003;304(2):881-8.
2002: Weidong He; Miroslav Cik; Luc Van Puyvelde; Jacky Van Dun; Giovanni Appendino; Anne Lesage; Ilse Van der Lindin; Josée E Leysen; Walter Wouters; Simon G Mathenge; Francis P Mudida; Norbert De Kimpe
Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii.
Bioorganic & medicinal chemistry 2002;10(10):3245-55.
2002: Jean-Pierre Bongartz; Raymond Stokbroekx; Marcel Van der Aa; Marcel Luyckx; Marc Willems; Marc Ceusters; Lieven Meerpoel; Gerda Smets; Tine Jansen; Walter Wouters; Charlie Bowden; Lisa Valletta; Mark Herb; Rose Tominovich; Robert W Tuman
Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives.
Bioorganic & medicinal chemistry letters 2002;12(4):589-91.
2002: Jim Van Heusden; R Van Ginckel; Hélène Bruwiere; P Moelans; B Janssen; wim joanna floren; B J van der Leede; Jacky Van Dun; G Sanz; Marc Venet; Lieve Dillen; C Van Hove; Gustaaf H M Willemsens; Michel Janicot; Walter Wouters
Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity.
British journal of cancer 2002;86(4):605-11.
2001: David W End; Gerda Smets; Alison V Todd; T L Applegate; Caroline J Fuery; Patrick Angibaud; Marc Venet; G Sanz; H Poignet; Stacy Skrzat; A Devine; Walter Wouters; Charlie Bowden
Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.
Cancer research 2001;61(1):131-7.
1998: Jim Van Heusden; Walter Wouters; Frans C S Ramaekers; MD Krekels; Lieve Dillen; Marcel Borgers; Gerda Smets
The antiproliferative activity of all-trans-retinoic acid catabolites and isomers is differentially modulated by liarozole-fumarate in MCF-7 human breast cancer cells.
British journal of cancer 1998;77(8):1229-35.
1998: Eddy Freyne; A Raeymaekers; Marc Venet; G Sanz; Walter Wouters; R De Coster; J V Wauwe
Synthesis of LIAZAL, a retinoic acid metabolism blocking agent (RAMBA) with potential clinical applications in oncology and dermatology.
Bioorganic & medicinal chemistry letters 1998;8(3):267-72.
1998: Jim Van Heusden; Walter Wouters; Frans C S Ramaekers; MD Krekels; Lieve Dillen; Marcel Borgers; Gerda Smets
All-trans-retinoic acid metabolites significantly inhibit the proliferation of MCF-7 human breast cancer cells in vitro.
British journal of cancer 1998;77(1):26-32.
1997: MD Krekels; A Verhoeven; Jacky Van Dun; W Cools; C Van Hove; Lieve Dillen; M C Coene; Walter Wouters
Induction of the oxidative catabolism of retinoid acid in MCF-7 cells.
British journal of cancer 1997;75(8):1098-104.
1996: Jim Van Heusden; Marcel Borgers; Frans C S Ramaekers; B Xhonneux; Walter Wouters; R De Coster; Gerda Smets
Liarozole potentiates the all-trans-retinoic acid-induced structural remodelling in human breast carcinoma MCF-7 cells in vitro.
European journal of cell biology 1996;71(1):89-98.
1996: M D Krekels; J Zimmerman; B Janssens; R Van Ginckel; W Cools; C Van Hove; M C Coene; Walter Wouters
Analysis of the oxidative catabolism of retinoic acid in rat Dunning R3327G prostate tumors.
The Prostate 1996;29(1):36-41.
1996: R De Coster; Walter Wouters; J Bruynseels
P450-dependent enzymes as targets for prostate cancer therapy.
The Journal of steroid biochemistry and molecular biology 1996;56(1-6 Spec No):133-43.
1994: Walter Wouters; Eric Snoeck; R De Coster
Vorozole, a specific non-steroidal aromatase inhibitor.
Breast cancer research and treatment 1994;30(1):89-94.
1993: Walter Wouters; R Van Ginckel; M Krekels; C Bowden; R De Coster
Pharmacology of vorozole.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):617-21.
1992: R De Coster; Walter Wouters; R Van Ginckel; D End; M Krekels; M C Coene; C Bowden
Experimental studies with liarozole (R 75,251): an antitumoral agent which inhibits retinoic acid breakdown.
The Journal of steroid biochemistry and molecular biology 1992;43(1-3):197-201.
1992: Walter Wouters; J van Dun; A Dillen; M C Coene; W Cools; R De Coster
Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells.
Cancer research 1992;52(10):2841-6.
1992: M D Krekels; Walter Wouters; R Van Ginckel; B Janssens; M Callens; R De Coster
Aromatase inhibition by R 83 842, the dextro isomer of R 76 713, in JEG-3 choriocarcinoma grown in ovariectomized nude mice.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):761-4.
1991: M D Krekels; Walter Wouters; R De Coster; R Van Ginckel; A Leonaers; Paul A J Janssen
Aromatase in the human choriocarcinoma JEG-3: inhibition by R 76 713 in cultured cells and in tumors grown in nude mice.
The Journal of steroid biochemistry and molecular biology 1991;38(4):415-22.
1990: Walter Wouters; R De Coster; J van Dun; M D Krekels; A Dillen; A Raeymaekers; E Freyne; J Van Gelder; G Sanz; M Venet
Comparative effects of the aromatase inhibitor R76713 and of its enantiomers R83839 and R83842 on steroid biosynthesis in vitro and in vivo.
The Journal of steroid biochemistry and molecular biology 1990;37(6):1049-54.
1990: R De Coster; Walter Wouters; C R Bowden; Hugo F Vanden Bossche; J Bruynseels; R W Tuman; R Van Ginckel; Eric Snoeck; Achiel Van Peer; Paul A J Janssen
New non-steroidal aromatase inhibitors: focus on R76713.
The Journal of steroid biochemistry and molecular biology 1990;37(3):335-41.
1990: Walter Wouters; R De Coster; D Beerens; R Doolaege; J A Gruwez; K Van Camp; H Van Der Pas; B van Herendael
Potency and selectivity of the aromatase inhibitor R 76,713. A study in human ovarian, adipose stromal, testicular and adrenal cells.
Journal of steroid biochemistry 1990;36(1-2):57-65.
1990: M D Krekels; Walter Wouters; R De Coster
Aromatase inhibition by R 76 713: a kinetic analysis in rat ovarian homogenates.
Steroids 1990;55(2):69-73.
1990: R Van Ginckel; R De Coster; Walter Wouters; W Vanherck; R van der Veer; N Goeminne; E Jagers; H Van Cauteren; Luc Wouters; W Distelmans
Antitumoral effects of R 75251 on the growth of transplantable R3327 prostatic adenocarcinoma in rats.
The Prostate 1990;16(4):313-23.
1990: J Bruynseels; R De Coster; P Van Rooy; Walter Wouters; M C Coene; Eric Snoeck; A Raeymaekers; E Freyne; G Sanz; G Vanden Bussche
R 75251, a new inhibitor of steroid biosynthesis.
The Prostate 1990;16(4):345-57.
1990: R De Coster; R Van Ginckel; Walter Wouters; N Goeminne; W Vanherck; M Byloos
Endocrine and antitumoral effects of R76713 in rats.
Journal of enzyme inhibition 1990;4(2):159-67.
1989: Walter Wouters; R De Coster; M Krekels; J van Dun; D Beerens; C Haelterman; A Raeymaekers; E Freyne; J Van Gelder; M Venet
R 76713, a new specific non-steroidal aromatase inhibitor.
Journal of steroid biochemistry 1989;32(6):781-8.
1989: Walter Wouters; R De Coster; R W Tuman; C R Bowden; J Bruynseels; H Vanderpas; P Van Rooy; W K Amery; Paul A J Janssen
Aromatase inhibition by R 76713: experimental and clinical pharmacology.
Journal of steroid biochemistry 1989;34(1-6):427-30.
1988: R De Coster; Walter Wouters; D Beerens; C Haelterman; R Doolaege; N Goeminne; M Krekels
Comparative effects of etomidate and its fluoro analogue, R 8110 on testicular, adrenal and ovarian steroid biosynthesis.
Journal of veterinary pharmacology and therapeutics 1988;11(4):345-53.
1988: Walter Wouters; R De Coster; N Goeminne; D Beerens; J van Dun
Aromatase inhibition by the antifungal ketoconazole.
Journal of steroid biochemistry 1988;30(1-6):387-9.
1987: Walter Wouters; J Van Dun; P M Laduron
Identification of the serotonin-S2 receptor ligand binding site by photoaffinity labelling with 7-azido-8-[125I]ketanserin ([125I]AZIK).
FEBS letters 1987;213(2):359-64.
1986: Walter Wouters; J Van Dun; P M Laduron
7-Amino-8-[125I]-ketanserin ([125I]AMIK), a highly sensitive, serotonin-S2 receptor ligand.
Biochemical pharmacology 1986;35(19):3199-202.
1986: Walter Wouters; C G Janssen; J Van Dun; J B Thijssen; P M Laduron
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.
Journal of medicinal chemistry 1986;29(9):1663-8.
1986: Walter Wouters; J J van Hertrooy; M D Krekels; P M Laduron
Reconstitution of solubilized serotonin-S2 receptors into phospholipid vesicles.
Journal of receptor research 1986;6(3-4):271-82.
1985: Walter Wouters; J Van Dun; J E Leysen; P M Laduron
Solubilization of rat brain serotonin-S2 receptors using CHAPS/salt.
European journal of pharmacology 1985;115(1):1-9.
1985: Walter Wouters; J Van Dun; J E Leysen; P M Laduron
Photoaffinity probes for serotonin and histamine receptors. Synthesis and characterization of two azide analogues of ketanserin.
The Journal of biological chemistry 1985;260(14):8423-9.
1985: Walter Wouters; J Van Dun; J E Leysen; P M Laduron
Differential photoaffinity labelling of serotonin-S2 receptors and histamine-H1 receptors using 7-azidoketanserin.
FEBS letters 1985;182(2):291-6.
1985: Walter Wouters; J Van Dun; J E Leysen; P M Laduron
Photoaffinity labelling of serotonin-S2 receptors with 7-azidoketanserin.
European journal of pharmacology 1985;107(3):399-400.
1984: Walter Wouters; J van Dun; P M Laduron
Characterization of cholate-solubilized dopamine receptors from human, dog and rat brain.
Biochemical pharmacology 1984;33(24):4039-44.
1984: Walter Wouters; J Van Dun; P M Laduron
Photoaffinity labelling of dopamine receptors. Synthesis and binding characteristics of azapride.
European journal of biochemistry / FEBS 1984;145(2):273-8.
1984: Walter Wouters; J Van Dun; P M Laduron
Photoaffinity labeling of human brain dopamine receptors.
Biochemical pharmacology 1984;33(21):3517-20.