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Fionula Brennan

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Disorders

Rheumatoid Arthritis

Anatomy

Living Beings

Physiology

Lymphocyte Activation

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Publications

TOP 3
Hillyer Philippa; Larché Maggie J; Bowman Edward P; McClanahan Terrill K; de Waal Malefyt Rene; Schewitz Lauren P; Giddins Grey; Feldmann Marc; Kastelein Robert A; Brennan Fionula M
Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.
Kuai Jun; Gregory Bernard; Hill Andrew; Pittman Debra D; Feldman Jeffrey L; Brown Tom; Carito Brenda; O'Toole Margot; Ramsey Renee; Adolfsson Oskar; Shields Kathleen M; Dower Ken; Hall J Perry; Kurdi Yahya; Beech Jonathan T; Nanchahal Jagdeep; Feldmann Marc; Foxwell Brian M; Brennan Fionula M; Winkler David G; Lin Lih-Ling
TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.
Sumariwalla P F; Palmer C D; Pickford L B; Feldmann M; Foxwell B M J; Brennan F M
Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.

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All Publications

2009: Hillyer Philippa; Larché Maggie J; Bowman Edward P; McClanahan Terrill K; de Waal Malefyt Rene; Schewitz Lauren P; Giddins Grey; Feldmann Marc; Kastelein Robert A; Brennan Fionula M
Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.
Rheumatology (Oxford, England) 2009;48(12):1581-9.
2009: Kuai Jun; Gregory Bernard; Hill Andrew; Pittman Debra D; Feldman Jeffrey L; Brown Tom; Carito Brenda; O'Toole Margot; Ramsey Renee; Adolfsson Oskar; Shields Kathleen M; Dower Ken; Hall J Perry; Kurdi Yahya; Beech Jonathan T; Nanchahal Jagdeep; Feldmann Marc; Foxwell Brian M; Brennan Fionula M; Winkler David G; Lin Lih-Ling
TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.
Rheumatology (Oxford, England) 2009;48(11):1352-8.
2009: Sumariwalla P F; Palmer C D; Pickford L B; Feldmann M; Foxwell B M J; Brennan F M
Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.
Rheumatology (Oxford, England) 2009;48(1):32-8.
2008: Sacre Sandra M; Lo Alexandra; Gregory Bernard; Simmonds Rachel E; Williams Lynn; Feldmann Marc; Brennan Fionula M; Foxwell Brian M
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):8002-9.
2008: Brennan Fionula M; McInnes Iain B
Evidence that cytokines play a role in rheumatoid arthritis.
The Journal of clinical investigation 2008;118(11):3537-45.
2008: Andersson A K; Feldmann M; Brennan F M
Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis.
Scandinavian journal of immunology 2008;68(1):103-11.
2008: Brennan Fionula M; Green Patricia; Amjadi Parisa; Robertshaw Heidi J; Alvarez-Iglesias Montserrat; Takata Masao
Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism.
European journal of immunology 2008;38(4):1106-17.
2008: Elliot Michael J; Maini Ravinder N; Feldmann Marc; Long-Fox Alice; Charles Peter; Katasikis Peter; Brennan Fionula M; Bijl Hanny; Ghrayeb John; Woody James N
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
Arthritis and rheumatism 2008;58(2 Suppl):S92-S101.
2008: Andersson Anna K; Li Ching; Brennan Fionula M
Recent developments in the immunobiology of rheumatoid arthritis.
Arthritis research & therapy 2008;10(2):204.
2008: Brennan Fionula M; Smith Nicola M G; Owen Sally; Li Ching; Amjadi Parisa; Green Patricia; Andersson Anna; Palfreeman Andrew C; Hillyer Philippa; Foey Andrew; Beech Jonathan T; Feldmann Marc
Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function.
Arthritis research & therapy 2008;10(2):R36.
2007: Sacre Sandra M; Drexler Stefan K; Andreakos Evangelos; Feldmann Marc; Brennan Fionula M; Foxwell Brian M J
Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.
Annals of the rheumatic diseases 2007;66 Suppl 3():iii81-6.
2007: Zhang Zhuoli; Gorman Claire L; Vermi Anna-Chiara; Monaco Claudia; Foey Andrew; Owen Sally; Amjadi Parisa; Vallance Alena; McClinton Catherine; Marelli-Berg Federica; Isomäki Pia; Russell Andrew; Dazzi Francesco; Vyse Timothy J; Brennan Fionula M; Cope Andrew P
TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues.
Blood 2007;109(10):4328-35.
2007: Edwards Christopher J; Feldman Jeffrey L; Beech Jonathan; Shields Kathleen M; Stover Jennifer A; Trepicchio William L; Larsen Glenn; Foxwell Brian Mj; Brennan Fionula M; Feldmann Marc; Pittman Debra D
Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis.
Molecular medicine (Cambridge, Mass.) 2007;13(1-2):40-58.
2007: Beech Jonathan T; Brennan Fionula M
Preparation of mononuclear cells from synovial tissue.
Methods in molecular medicine 2007;135():105-19.
2006: Horwood Nicole J; Page Theresa H; McDaid John P; Palmer Christine D; Campbell Jamie; Mahon Tara; Brennan Fionula M; Webster David; Foxwell Brian M J
Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3635-41.
2006: Beech Jonathan T; Andreakos Evangelos; Ciesielski Cathleen J; Green Patricia; Foxwell Brian M J; Brennan Fionula M
T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFkappaB: implications for rheumatoid arthritis.
Arthritis research & therapy 2006;8(6):R168.
2006: Brennan F M; Foey A D; Feldmann M
The importance of T cell interactions with macrophages in rheumatoid cytokine production.
Current topics in microbiology and immunology 2006;305():177-94.
2005: O'Dea Kieran P; Young Arnold J; Yamamoto Hirotoshi; Robotham James L; Brennan Fionula M; Takata Masao
Lung-marginated monocytes modulate pulmonary microvascular injury during early endotoxemia.
American journal of respiratory and critical care medicine 2005;172(9):1119-27.
2005: Feldmann Marc; Brennan Fionula M; Foxwell Brian M J; Taylor Peter C; Williams Richard O; Maini R N
Anti-TNF therapy: where have we got to in 2005?
Journal of autoimmunity 2005;25 Suppl():26-8.
2004: Campbell Jamie; Ciesielski Cathleen J; Hunt Abigail E; Horwood Nicole J; Beech Jonathan T; Hayes Louise A; Denys Agnes; Feldmann Marc; Brennan Fionula M; Foxwell Brian M J
A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6928-37.
2004: Foey Andrew D; Brennan Fionula M
Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10.
Immunology 2004;112(1):44-53.
2004: Feldmann Marc; Brennan Fionula M; Williams Richard O; Woody James N; Maini Ravinder N
The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.
Best practice & research. Clinical rheumatology 2004;18(1):59-80.
2004: Feldmann Marc; Brennan Fionula M; Paleolog Ewa; Cope Andrew; Taylor Peter; Williams Richard; Woody Jim; Maini Ravinder N
Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?
Novartis Foundation symposium 2004;256():53-69; discussion 69-73, 106-11, 266-9.
2003: Yoshimura S; Bondeson J; Brennan F M; Foxwell B M J; Feldmann M
Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.
Scandinavian journal of immunology 2003;58(2):165-72.
2003: Andreakos Evangelos; Smith Clive; Kiriakidis Serafim; Monaco Claudia; de Martin Rainer; Brennan Fionula M; Paleolog Ewa; Feldmann Marc; Foxwell Brian M
Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.
Arthritis and rheumatism 2003;48(7):1901-12.
2003: Lindsay J O; Ciesielski C J; Scheinin T; Brennan F M; Hodgson H J
Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis.
Gut 2003;52(7):981-7.
2003: Horwood Nicole J; Mahon Tara; McDaid John P; Campbell Jamie; Mano Hiroyuki; Brennan Fionula M; Webster David; Foxwell Brian M J
Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production.
The Journal of experimental medicine 2003;197(12):1603-11.
2003: Calder V L; Bondeson J; Brennan F M; Foxwell B M J; Feldmann M
Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.
Scandinavian journal of immunology 2003;57(3):261-70.
2003: Lindsay J O; Ciesielski C J; Scheinin T; Brennan F M; Hodgson H J
Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis.
Gut 2003;52(3):363-9.
2003: Andreakos Evangelos; Smith Clive; Monaco Claudia; Brennan Fionula M; Foxwell Brian M; Feldmann Marc
Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.
Blood 2003;101(3):983-91.
2003: Foey Andrew D; Field Sarah; Ahmed Salman; Jain Abhilash; Feldmann Marc; Brennan Fionula M; Williams Richard
Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis.
Arthritis research & therapy 2003;5(6):R317-28.
2002: Feldmann M; Andreakos E; Smith C; Bondeson J; Yoshimura S; Kiriakidis S; Monaco C; Gasparini C; Sacre S; Lundberg A; Paleolog E; Horwood N J; Brennan F M; Foxwell B M J
Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
Annals of the rheumatic diseases 2002;61 Suppl 2():ii13-8.
2002: Andreakos Evangelos T; Foxwell Brian M; Brennan Fionula M; Maini Ravinder N; Feldmann Marc
Cytokines and anti-cytokine biologicals in autoimmunity: present and future.
Cytokine & growth factor reviews 2002;13(4-5):299-313.
2002: Brennan Fionula M; Hayes Amanda L; Ciesielski Cathleen J; Green Patricia; Foxwell Brian M J; Feldmann Marc
Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.
Arthritis and rheumatism 2002;46(1):31-41.
2002: Horwood Nicole J; Smith Clive; Andreakos Evangelos; Quattrocchi Emilia; Brennan Fionula M; Feldmann Marc; Foxwell Brian M J
High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.
Arthritis research 2002;4 Suppl 3():S215-25.
2001: Foxwell B M; Yoshimura S; Bondeson J; Brennan F M; Feldmann M
High efficiency gene transfer is an efficient way of defining therapeutic targets: a functional genomics approach.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii13-7.
2001: Foey A D; Feldmann M; Brennan F M
CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.
Cytokine 2001;16(4):131-42.
2001: Smith C; Andreakos E; Crawley J B; Brennan F M; Feldmann M; Foxwell B M
NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5895-903.
2001: Yoshimura S; Bondeson J; Brennan F M; Foxwell B M; Feldmann M
Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI.
European journal of immunology 2001;31(6):1883-93.
2001: Lindsay J O; Ciesielski C J; Scheinin T; Hodgson H J; Brennan F M
The prevention and treatment of murine colitis using gene therapy with adenoviral vectors encoding IL-10.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7625-33.
2001: Yoshimura S; Bondeson J; Foxwell B M; Brennan F M; Feldmann M
Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.
International immunology 2001;13(5):675-83.
2001: Feldmann M; Maini R N; Bondeson J; Taylor P; Foxwell B M; Brennan F M
Cytokine blockade in rheumatoid arthritis.
Advances in experimental medicine and biology 2001;490():119-27.
2001: Brennan F M
A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" by Wim B van den Berg.
Arthritis research 2001;3(4):211-3; discussion 214-5.
2000: Feldmann M; Miotla J; Paleolog E; Williams R; Malfait A M; Taylor P; Brennan F M; Maini R N
Future prospects for anti-cytokine treatment.
Annals of the rheumatic diseases 2000;59 Suppl 1():i119-22.
2000: Foey A D; Feldmann M; Brennan F M
Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression.
Cytokine 2000;12(10):1496-505.
1999: Maini R N; Taylor P C; Paleolog E; Charles P; Ballara S; Brennan F M; Feldmann M
Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis.
Annals of the rheumatic diseases 1999;58 Suppl 1():I56-60.
1999: Feldmann M; Bondeson J; Brennan F M; Foxwell B M; Maini R N
The rationale for the current boom in anti-TNFalpha treatment. Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha and minimise hazards?
Annals of the rheumatic diseases 1999;58 Suppl 1():I27-31.
1999: Hayes A L; Smith C; Foxwell B M; Brennan F M
CD45-induced tumor necrosis factor alpha production in monocytes is phosphatidylinositol 3-kinase-dependent and nuclear factor-kappaB-independent.
The Journal of biological chemistry 1999;274(47):33455-61.
1999: Butler D M; Malfait A M; Maini R N; Brennan F M; Feldmann M
Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis.
European journal of immunology 1999;29(7):2205-12.
1999: Bondeson J; Browne K A; Brennan F M; Foxwell B M; Feldmann M
Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2939-45.
1998: Feldman M; Taylor P; Paleolog E; Brennan F M; Maini R N
Anti-TNF alpha therapy is useful in rheumatoid arthritis and Crohn's disease: analysis of the mechanism of action predicts utility in other diseases.
Transplantation proceedings 1998;30(8):4126-7.
1998: Malfait A M; Butler D M; Presky D H; Maini R N; Brennan F M; Feldmann M
Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis.
Clinical and experimental immunology 1998;111(2):377-83.
1998: Foey A D; Parry S L; Williams L M; Feldmann M; Foxwell B M; Brennan F M
Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):920-8.
1997: Butler D M; Malfait A M; Mason L J; Warden P J; Kollias G; Maini R N; Feldmann M; Brennan F M
DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2867-76.
1997: Brennan F M; Browne K A; Green P A; Jaspar J M; Maini R N; Feldmann M
Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy.
British journal of rheumatology 1997;36(6):643-50.
1997: Maini R N; Elliott M; Brennan F M; Williams R O; Feldmann M
TNF blockade in rheumatoid arthritis: implications for therapy and pathogenesis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1997;105(4):257-63.
1997: Parry S L; Sebbag M; Feldmann M; Brennan F M
Contact with T cells modulates monocyte IL-10 production: role of T cell membrane TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3673-81.
1997: Sebbag M; Parry S L; Brennan F M; Feldmann M
Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-alpha, but not interleukin-10: possible relevance to pathophysiology of rheumatoid arthritis.
European journal of immunology 1997;27(3):624-32.
1996: Williams L M; Gibbons D L; Gearing A; Maini R N; Feldmann M; Brennan F M
Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.
The Journal of clinical investigation 1996;97(12):2833-41.
1995: Scallon B J; Trinh H; Nedelman M; Brennan F M; Feldmann M; Ghrayeb J
Functional comparisons of different tumour necrosis factor receptor/IgG fusion proteins.
Cytokine 1995;7(8):759-70.
1995: Maini R N; Elliott M J; Brennan F M; Feldmann M
Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)
Clinical and experimental immunology 1995;101(2):207-12.
1995: Butler D M; Maini R N; Feldmann M; Brennan F M
Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist.
European cytokine network 1995;6(4):225-30.
1995: Brennan F M; Gibbons D L; Cope A P; Katsikis P; Maini R N; Feldmann M
TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.
Scandinavian journal of immunology 1995;42(1):158-65.
1995: Maini R N; Elliott M J; Brennan F M; Williams R O; Chu C Q; Paleolog E; Charles P J; Taylor P C; Feldmann M
Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease.
Immunological reviews 1995;144():195-223.
1995: Cope A P; Aderka D; Wallach D; Kahan M; Chu N R; Brennan F M; Feldmann M
Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF.
Immunology 1995;84(1):21-30.
1995: Brennan F M; Cope A P; Katsikis P; Gibbons D L; Maini R N; Feldmann M
Selective immunosuppression of tumour necrosis factor-alpha in rheumatoid arthritis.
Chemical immunology 1995;60():48-60.
1994: Butler D M; Scallon B; Meager A; Kissonerghis M; Corcoran A; Chernajovsky Y; Feldmann M; Ghrayeb J; Brennan F M
TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells.
Cytokine 1994;6(6):616-23.
1994: Maini R N; Elliott M; Brennan F M; Williams R O; Feldmann M
Targeting TNF alpha for the therapy of rheumatoid arthritis.
Clinical and experimental rheumatology 1994;12 Suppl 11():S63-6.
1994: Butler D M; Feldmann M; Di Padova F; Brennan F M
p55 and p75 tumor necrosis factor receptors are expressed and mediate common functions in synovial fibroblasts and other fibroblasts.
European cytokine network 1994;5(5):441-8.
1994: Gibbons D L; Rowe M; Cope A P; Feldmann M; Brennan F M
Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines.
European journal of immunology 1994;24(8):1879-85.
1994: Cope A P; Londei M; Chu N R; Cohen S B; Elliott M J; Brennan F M; Maini R N; Feldmann M
Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.
The Journal of clinical investigation 1994;94(2):749-60.
1994: Katsikis P D; Chu C Q; Brennan F M; Maini R N; Feldmann M
Immunoregulatory role of interleukin 10 in rheumatoid arthritis.
The Journal of experimental medicine 1994;179(5):1517-27.
1993: Elliott M J; Maini R N; Feldmann M; Long-Fox A; Charles P; Katsikis P; Brennan F M; Walker J; Bijl H; Ghrayeb J
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
Arthritis and rheumatism 1993;36(12):1681-90.
1993: Kristensen M; Chu C Q; Eedy D J; Feldmann M; Brennan F M; Breathnach S M
Localization of tumour necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor.
Clinical and experimental immunology 1993;94(2):354-62.
1993: Cope A P; Gibbons D L; Aderka D; Foxwell B M; Wallach D; Maini R N; Feldmann M; Brennan F M
Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.
Cytokine 1993;5(3):205-12.
1993: Maini R N; Brennan F M; Williams R; Chu C Q; Cope A P; Gibbons D; Elliott M; Feldmann M
TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.
Clinical and experimental rheumatology 1993;11 Suppl 8():S173-5.
1992: Deleuran B W; Chu C Q; Field M; Brennan F M; Katsikis P; Feldmann M; Maini R N
Localization of interleukin-1 alpha, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage/pannus junction in rheumatoid arthritis.
British journal of rheumatology 1992;31(12):801-9.
1992: Kristensen M; Deleuran B; Eedy D J; Feldmann M; Breathnach S M; Brennan F M
Distribution of interleukin 1 receptor antagonist protein (IRAP), interleukin 1 receptor, and interleukin 1 alpha in normal and psoriatic skin. Decreased expression of IRAP in psoriatic lesional epidermis.
The British journal of dermatology 1992;127(4):305-11.
1992: Deleuran B W; Chu C Q; Field M; Brennan F M; Mitchell T; Feldmann M; Maini R N
Localization of tumor necrosis factor receptors in the synovial tissue and cartilage-pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor alpha.
Arthritis and rheumatism 1992;35(10):1170-8.
1992: Cope A P; Aderka D; Doherty M; Engelmann H; Gibbons D; Jones A C; Brennan F M; Maini R N; Wallach D; Feldmann M
Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases.
Arthritis and rheumatism 1992;35(10):1160-9.
1992: Brennan F M; Gibbons D L; Mitchell T; Cope A P; Maini R N; Feldmann M
Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints.
European journal of immunology 1992;22(7):1907-12.
1992: Brennan F M; Maini R N; Feldmann M
TNF alpha--a pivotal role in rheumatoid arthritis?
British journal of rheumatology 1992;31(5):293-8.
1992: Feldmann M; Brennan F M; Williams R O; Cope A P; Gibbons D L; Katsikis P D; Maini R N
Evaluation of the role of cytokines in autoimmune disease: the importance of TNF alpha in rheumatoid arthritis.
Progress in growth factor research 1992;4(3):247-55.
1991: Haworth C; Brennan F M; Chantry D; Turner M; Maini R N; Feldmann M
Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha.
European journal of immunology 1991;21(10):2575-9.
1991: Turner M; Chantry D; Katsikis P; Berger A; Brennan F M; Feldmann M
Induction of the interleukin 1 receptor antagonist protein by transforming growth factor-beta.
European journal of immunology 1991;21(7):1635-9.
1991: Feldmann M; Brennan F M; Chantry D; Haworth C; Turner M; Katsikis P; Londei M; Abney E; Buchan G; Barrett K
Cytokine assays: role in evaluation of the pathogenesis of autoimmunity.
Immunological reviews 1991;119():105-23.
1991: Brennan F M; Field M; Chu C Q; Feldmann M; Maini R N
Cytokine expression in rheumatoid arthritis.
British journal of rheumatology 1991;30 Suppl 1():76-80.
1990: Brennan F M; Zachariae C O; Chantry D; Larsen C G; Turner M; Maini R N; Matsushima K; Feldmann M
Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells.
European journal of immunology 1990;20(9):2141-4.
1990: Brennan F M; Chantry D; Turner M; Foxwell B; Maini R; Feldmann M
Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: lack of effect on spontaneous cytokine production in joint cell cultures.
Clinical and experimental immunology 1990;81(2):278-85.
1990: Maini R N; Plater-Zyberk C; Brown C M; Aghamohammadi S; Brennan F M; Feldmann M
CD5+B cells in rheumatoid arthritis and Sjögren's syndrome.
Clinical and experimental rheumatology 1990;8 Suppl 5():67-8.
1990: Feldmann M; Brennan F M; Chantry D; Haworth C; Turner M; Abney E; Buchan G; Barrett K; Barkley D; Chu A
Cytokine production in the rheumatoid joint: implications for treatment.
Annals of the rheumatic diseases 1990;49 Suppl 1():480-6.
1989: Field M; Melsom R D; Brennan F M; Williams D G; Schreiber L; McCarthy D A; Maini R N;
Rapid clearance of the lupus antigen Sm is delayed by autoantibody: a possible mechanism of autoimmunity perpetuation.
Clinical and experimental immunology 1989;78(3):460-4.
1989: Brennan F M; Chantry D; Jackson A; Maini R; Feldmann M
Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis.
Lancet 1989;2(8657):244-7.
1989: Brennan F M; Chantry D; Jackson A M; Maini R N; Feldmann M
Cytokine production in culture by cells isolated from the synovial membrane.
Journal of autoimmunity 1989;2 Suppl():177-86.
1989: Plater-Zyberk C; Brennan F M; Feldmann M; Maini R N
'Fetal-type' B and T lymphocytes in rheumatoid arthritis and primary Sjögren's syndrome.
Journal of autoimmunity 1989;2 Suppl():233-41.
1988: Brennan F M; Londei M; Jackson A M; Hercend T; Brenner M B; Maini R N; Feldmann M
T cells expressing gamma delta chain receptors in rheumatoid arthritis.
Journal of autoimmunity 1988;1(4):319-26.
1988: Brennan F M; Andrew E M; Williams D G; Maini R N
Anti-nRNP anti-nuclear antibody-secreting cells are represented in the B-lymphocyte repertoire of normal and MRL/MP-lpr/lpr lupus mice.
Immunology 1988;63(2):213-7.
1987: Field M; Brennan F M; McCarthy D; Mumford P; Maini R N
MRL-lpr/lpr mice show an impairment of IgG aggregate removal which relates to parameters of disease activity.
Immunology 1987;61(4):463-7.
1985: Field M; Brennan F M; Melsom R D; McCarthy D; Mumford P; Maini R N
MRL mice show an age-related impairment of IgG aggregate removal from the circulation.
Clinical and experimental immunology 1985;61(1):195-202.

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