FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Fionula Brennan

Research Profile

Disorders

Rheumatoid Arthritis

Chemicals & Drugs

Anatomy

Living Beings

Physiology

Lymphocyte Activation

Co-author Network

Publications

TOP 3
Jane Bryant; David J Ahern; Fionula M Brennan
CXCR4 and vascular cell adhesion molecule 1 are key chemokine/adhesion receptors in the migration of cytokine-activated T cells.
Gideon Agbanoma; Darren Ennis; Ching Li; Andrew C Palfreeman; Lynn M Williams; Fionula M Brennan
Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism.
Paul A Beavis; Parisa Amjadi; Adam P Cribbs; Eugene Eyo Akujuru; Patricia Green; Bernard Gregory; Alan Kennedy; Andrew C Palfreeman; Fionula M Brennan
Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Fionula Brennan (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Jane Bryant; David J Ahern; Fionula M Brennan
CXCR4 and vascular cell adhesion molecule 1 are key chemokine/adhesion receptors in the migration of cytokine-activated T cells.
Arthritis and rheumatism 2012;64(7):2137-46.
2012: Gideon Agbanoma; Darren Ennis; Ching Li; Andrew C Palfreeman; Lynn M Williams; Fionula M Brennan
Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(3):1307-17.
2011: Paul A Beavis; Parisa Amjadi; Adam P Cribbs; Eugene Eyo Akujuru; Patricia Green; Bernard Gregory; Alan Kennedy; Andrew C Palfreeman; Fionula M Brennan
Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(40):16717-22.
2011: Anna K Andersson; Henrik Agersø; David Ahern; Parisa Amjadi; Chiwen Chang; Eugene Eyo Akujuru; Claus Haase; Fiona E McCann; Kay McNamee; Vibeke W Stennicke; Percy F Sumariwalla; Ditte Tornehave; John Trowsdale; Birgitte Uraø; Fionula M Brennan
Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.
Arthritis and rheumatism 2011;63(9):2617-29.
2011: David J Ahern; Fionula M Brennan
The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: major contributors or essential homeostatic modulators?
Immunology letters 2011;136(2):115-21.
2011: Ching Li; Paul Beavis; Andrew C Palfreeman; Parisa Amjadi; Alan Kennedy; Fionula M Brennan
Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated T cells, but acts as a negative regulator in T cells activated through the T-cell receptor.
Immunology 2011;132(1):104-10.
2010: Theresa H Page; Jeremy J O Turner; Anthony C Brown; Emma M Timms; Julia J Inglis; Fionula M Brennan; Brian M J Foxwell; Keith P Ray; Eugene Eyo Akujuru
Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3694-701.
2010: Fiona E McCann; Andrew C Palfreeman; Melanie Andrews; Dany P Perocheau; Julia J Inglis; Peter Schafer; Eugene Eyo Akujuru; Richard O Williams; Fionula M Brennan
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
Arthritis research & therapy 2010;12(3):R107.
2009: Philippa Hillyer; Mark Larché; Edward P Bowman; Terrill K McClanahan; Rene de Waal Malefyt; Lauren P Schewitz; Grey Giddins; Eugene Eyo Akujuru; Robert A Kastelein; Fionula M Brennan
Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.
Rheumatology (Oxford, England) 2009;48(12):1581-9.
2009: Jun Kuai; Bernard Gregory; Andrew Hill; Debra D Pittman; Jeffrey L Feldman; Tom Brown; Brenda Carito; Margot O'Toole; Renee Ramsey; Oskar Adolfsson; Kathleen M Shields; Ken Dower; J Perry Hall; Yahya Kurdi; Jonathan T Beech; Jagdeep Nanchahal; Marc Feldmann; Brian M Foxwell; Fionula M Brennan; David G Winkler; Lih-Ling Lin
TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.
Rheumatology (Oxford, England) 2009;48(11):1352-8.
2009: Percy F Sumariwalla; C D Palmer; L B Pickford; Eugene Eyo Akujuru; Brian M J Foxwell; Fionula M Brennan
Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.
Rheumatology (Oxford, England) 2009;48(1):32-8.
2008: Sandra M Sacre; Alexandra Lo; Bernard Gregory; Rachel E Simmonds; Lynn Williams; Eugene Eyo Akujuru; Fionula M Brennan; Brian M J Foxwell
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):8002-9.
2008: Fionula M Brennan; Iain B McInnes
Evidence that cytokines play a role in rheumatoid arthritis.
The Journal of clinical investigation 2008;118(11):3537-45.
2008: A K Andersson; Eugene Eyo Akujuru; Fionula M Brennan
Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis.
Scandinavian journal of immunology 2008;68(1):103-11.
2008: Fionula M Brennan; Patricia Green; Parisa Amjadi; Heidi J Robertshaw; Montserrat Alvarez-Iglesias; Masao Takata
Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism.
European journal of immunology 2008;38(4):1106-17.
2008: Michael J Elliot; Ravinder N Maini; Eugene Eyo Akujuru; Alice Long-Fox; Peter Charles; Peter Katasikis; Fionula M Brennan; Hanny Bijl; John Ghrayeb; James N Woody
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
Arthritis and rheumatism 2008;58(2 Suppl):S92-S101.
2008: Anna K Andersson; Ching Li; Fionula M Brennan
Recent developments in the immunobiology of rheumatoid arthritis.
Arthritis research & therapy 2008;10(2):204.
2008: Fionula M Brennan; Nicola M G Smith; Sally Owen; Ching Li; Parisa Amjadi; Patricia Green; Anna Andersson; Andrew C Palfreeman; Philippa Hillyer; Andrew D Foey; Jonathan T Beech; Eugene Eyo Akujuru
Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function.
Arthritis research & therapy 2008;10(2):R36.
2007: Sandra M Sacre; Stefan K Drexler; Evangelos Andreakos; Eugene Eyo Akujuru; Fionula M Brennan; Brian M J Foxwell
Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.
Annals of the rheumatic diseases 2007;66 Suppl 3():iii81-6.
2007: Zhuoli Zhang; Claire L Gorman; Anna-Chiara Vermi; Claudia Monaco; Andrew D Foey; Sally Owen; Parisa Amjadi; Alena Vallance; Catherine McClinton; Federica M Marelli-Berg; Pia Isomäki; Andrew Russell; Francesco Dazzi; Timothy J Vyse; Fionula M Brennan; Andrew P Cope
TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues.
Blood 2007;109(10):4328-35.
2007: Jonathan T Beech; Fionula M Brennan
Preparation of mononuclear cells from synovial tissue.
Methods in molecular medicine 2007;135():105-19.
2007: Christopher J Edwards; Jeffrey L Feldman; Jonathan Beech; Kathleen M Shields; Jennifer A Stover; William L Trepicchio; Glenn Larsen; Brian Mj Foxwell; Fionula M Brennan; Eugene Eyo Akujuru; Debra D Pittman
Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis.
Molecular medicine (Cambridge, Mass.) 2007;13(1-2):40-58.
2006: Nicole J Horwood; Theresa H Page; John P McDaid; Christine D Palmer; Jamie Campbell; Tara Mahon; Fionula M Brennan; David Webster; Brian M J Foxwell
Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3635-41.
2006: Jonathan T Beech; Evangelos Andreakos; Cathleen J Ciesielski; Patricia Green; Brian M J Foxwell; Fionula M Brennan
T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFkappaB: implications for rheumatoid arthritis.
Arthritis research & therapy 2006;8(6):R168.
2006: Fionula M Brennan; Andrew D Foey; Eugene Eyo Akujuru
The importance of T cell interactions with macrophages in rheumatoid cytokine production.
Current topics in microbiology and immunology 2006;305():177-94.
2005: Kieran P O'Dea; Arnold J Young; Hirotoshi Yamamoto; James L Robotham; Fionula M Brennan; Masao Takata
Lung-marginated monocytes modulate pulmonary microvascular injury during early endotoxemia.
American journal of respiratory and critical care medicine 2005;172(9):1119-27.
2005: Eugene Eyo Akujuru; Fionula M Brennan; Brian M J Foxwell; Peter C Taylor; Richard O Williams; R N Maini
Anti-TNF therapy: where have we got to in 2005?
Journal of autoimmunity 2005;25 Suppl():26-8.
2004: Jamie Campbell; Cathleen J Ciesielski; Abigail E Hunt; Nicole J Horwood; Jonathan T Beech; Louise A Hayes; Agnes Denys; Eugene Eyo Akujuru; Fionula M Brennan; Brian M J Foxwell
A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6928-37.
2004: Andrew D Foey; Fionula M Brennan
Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10.
Immunology 2004;112(1):44-53.
2004: Eugene Eyo Akujuru; Fionula M Brennan; Richard O Williams; Jim Woody; Ravinder N Maini
The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.
Best practice & research. Clinical rheumatology 2004;18(1):59-80.
2004: Eugene Eyo Akujuru; Fionula M Brennan; Ewa Paleolog; Andrew P Cope; Peter Taylor; Richard Williams; Jim Woody; Ravinder N Maini
Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?
Novartis Foundation symposium 2004;256():53-69; discussion 69-73, 106-11, 266-9.
2003: S Yoshimura; J Bondeson; Fionula M Brennan; Brian M J Foxwell; Eugene Eyo Akujuru
Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.
Scandinavian journal of immunology 2003;58(2):165-72.
2003: Evangelos Andreakos; Clive Smith; Serafim Kiriakidis; Claudia Monaco; Rainer de Martin; Fionula M Brennan; Ewa Paleolog; Eugene Eyo Akujuru; Brian M J Foxwell
Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.
Arthritis and rheumatism 2003;48(7):1901-12.
2003: JO Lindsay; Cathleen J Ciesielski; T Scheinin; Fionula M Brennan; Humphrey Hodgson
Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis.
Gut 2003;52(7):981-7.
2003: Nicole J Horwood; Tara Mahon; John P McDaid; Jamie Campbell; Hiroyuki Mano; Fionula M Brennan; David Webster; Brian M J Foxwell
Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production.
The Journal of experimental medicine 2003;197(12):1603-11.
2003: V L Calder; J Bondeson; Fionula M Brennan; Brian M J Foxwell; Eugene Eyo Akujuru
Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.
Scandinavian journal of immunology 2003;57(3):261-70.
2003: JO Lindsay; Cathleen J Ciesielski; T Scheinin; Fionula M Brennan; Humphrey Hodgson
Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis.
Gut 2003;52(3):363-9.
2003: Evangelos Andreakos; Clive Smith; Claudia Monaco; Fionula M Brennan; Brian M J Foxwell; Eugene Eyo Akujuru
Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.
Blood 2003;101(3):983-91.
2003: Andrew D Foey; Sarah Field; Salman Ahmed; Abhilash Jain; Eugene Eyo Akujuru; Fionula M Brennan; Richard Williams
Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis.
Arthritis research & therapy 2003;5(6):R317-28.
2002: Eugene Eyo Akujuru; Evangelos Andreakos; Clive Smith; J Bondeson; S Yoshimura; Serafim Kiriakidis; Claudia Monaco; C Gasparini; Sandra M Sacre; Anna M C Lundberg; Ewa Paleolog; Nicole J Horwood; Fionula M Brennan; Brian M J Foxwell
Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
Annals of the rheumatic diseases 2002;61 Suppl 2():ii13-8.
2002: Evangelos Andreakos; Brian M J Foxwell; Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
Cytokines and anti-cytokine biologicals in autoimmunity: present and future.
Cytokine & growth factor reviews 2002;13(4-5):299-313.
2002: Nicole J Horwood; Clive Smith; Evangelos Andreakos; Emilia Quattrocchi; Fionula M Brennan; Eugene Eyo Akujuru; Brian M J Foxwell
High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.
Arthritis research 2002;4 Suppl 3():S215-25.
2002: Fionula M Brennan; Amanda L Hayes; Cathleen J Ciesielski; Patricia Green; Brian M J Foxwell; Eugene Eyo Akujuru
Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.
Arthritis and rheumatism 2002;46(1):31-41.
2001: Andrew D Foey; Eugene Eyo Akujuru; Fionula M Brennan
CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.
Cytokine 2001;16(4):131-42.
2001: Clive Smith; Evangelos Andreakos; JB Crawley; Fionula M Brennan; Eugene Eyo Akujuru; Brian M J Foxwell
NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5895-903.
2001: Brian M J Foxwell; S Yoshimura; J Bondeson; Fionula M Brennan; Eugene Eyo Akujuru
High efficiency gene transfer is an efficient way of defining therapeutic targets: a functional genomics approach.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii13-7.
2001: JO Lindsay; Cathleen J Ciesielski; T Scheinin; Humphrey Hodgson; Fionula M Brennan
The prevention and treatment of murine colitis using gene therapy with adenoviral vectors encoding IL-10.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7625-33.
2001: S Yoshimura; J Bondeson; Fionula M Brennan; Brian M J Foxwell; Eugene Eyo Akujuru
Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI.
European journal of immunology 2001;31(6):1883-93.
2001: S Yoshimura; J Bondeson; Brian M J Foxwell; Fionula M Brennan; Eugene Eyo Akujuru
Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.
International immunology 2001;13(5):675-83.
2001: Eugene Eyo Akujuru; Ravinder N Maini; J Bondeson; P Taylor; Brian M J Foxwell; Fionula M Brennan
Cytokine blockade in rheumatoid arthritis.
Advances in experimental medicine and biology 2001;490():119-27.
2001: Fionula M Brennan
A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" by Wim B van den Berg.
Arthritis research 2001;3(4):211-3; discussion 214-5.
2000: Eugene Eyo Akujuru; JM Miotla; Ewa Paleolog; R Williams; Anne-Marie Malfait; P Taylor; Fionula M Brennan; Ravinder N Maini
Future prospects for anti-cytokine treatment.
Annals of the rheumatic diseases 2000;59 Suppl 1():i119-22.
2000: Andrew D Foey; Eugene Eyo Akujuru; Fionula M Brennan
Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression.
Cytokine 2000;12(10):1496-505.
1999: A L Hayes; C Smith; Brian M J Foxwell; Fionula M Brennan
CD45-induced tumor necrosis factor alpha production in monocytes is phosphatidylinositol 3-kinase-dependent and nuclear factor-kappaB-independent.
The Journal of biological chemistry 1999;274(47):33455-61.
1999: Ravinder N Maini; P C Taylor; Ewa Paleolog; P Charles; SC Ballara; Fionula M Brennan; Eugene Eyo Akujuru
Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis.
Annals of the rheumatic diseases 1999;58 Suppl 1():I56-60.
1999: Eugene Eyo Akujuru; J Bondeson; Fionula M Brennan; Brian M J Foxwell; Ravinder N Maini
The rationale for the current boom in anti-TNFalpha treatment. Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha and minimise hazards?
Annals of the rheumatic diseases 1999;58 Suppl 1():I27-31.
1999: DM Butler; Anne-Marie Malfait; R N Maini; Fionula M Brennan; Eugene Eyo Akujuru
Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis.
European journal of immunology 1999;29(7):2205-12.
1999: J Bondeson; K A Browne; Fionula M Brennan; Brian M J Foxwell; Eugene Eyo Akujuru
Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2939-45.
1998: M Feldman; P Taylor; Ewa Paleolog; Fionula M Brennan; R N Maini
Anti-TNF alpha therapy is useful in rheumatoid arthritis and Crohn's disease: analysis of the mechanism of action predicts utility in other diseases.
Transplantation proceedings 1998;30(8):4126-7.
1998: Anne-Marie Malfait; DM Butler; D H Presky; Ravinder N Maini; Fionula M Brennan; Eugene Eyo Akujuru
Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis.
Clinical and experimental immunology 1998;111(2):377-83.
1998: Andrew D Foey; SL Parry; Lynn M Williams; Eugene Eyo Akujuru; Brian M J Foxwell; Fionula M Brennan
Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):920-8.
1997: DM Butler; Anne-Marie Malfait; LJ Mason; P J Warden; george kollias; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2867-76.
1997: Fionula M Brennan; K A Browne; P A Green; J M Jaspar; Ravinder N Maini; Eugene Eyo Akujuru
Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy.
British journal of rheumatology 1997;36(6):643-50.
1997: SL Parry; M Sebbag; Eugene Eyo Akujuru; Fionula M Brennan
Contact with T cells modulates monocyte IL-10 production: role of T cell membrane TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3673-81.
1997: Ravinder N Maini; M Elliott; Fionula M Brennan; Richard O Williams; Eugene Eyo Akujuru
TNF blockade in rheumatoid arthritis: implications for therapy and pathogenesis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1997;105(4):257-63.
1997: M Sebbag; SL Parry; Fionula M Brennan; Eugene Eyo Akujuru
Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-alpha, but not interleukin-10: possible relevance to pathophysiology of rheumatoid arthritis.
European journal of immunology 1997;27(3):624-32.
1996: L M Williams; D L Gibbons; A Gearing; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.
The Journal of clinical investigation 1996;97(12):2833-41.
1995: B J Scallon; H Trinh; M Nedelman; Fionula M Brennan; Eugene Eyo Akujuru; J Ghrayeb
Functional comparisons of different tumour necrosis factor receptor/IgG fusion proteins.
Cytokine 1995;7(8):759-70.
1995: Ravinder N Maini; M J Elliott; Fionula M Brennan; Eugene Eyo Akujuru
Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)
Clinical and experimental immunology 1995;101(2):207-12.
1995: DM Butler; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist.
European cytokine network 1995;6(4):225-30.
1995: Fionula M Brennan; D L Gibbons; A P Cope; P Katsikis; Ravinder N Maini; Eugene Eyo Akujuru
TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.
Scandinavian journal of immunology 1995;42(1):158-65.
1995: Ravinder N Maini; M J Elliott; Fionula M Brennan; R O Williams; Cong-Qiu Chu; Ewa Paleolog; P J Charles; P C Taylor; Eugene Eyo Akujuru
Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease.
Immunological reviews 1995;144():195-223.
1995: A P Cope; D Aderka; David Wallach; M Kahan; N R Chu; Fionula M Brennan; Eugene Eyo Akujuru
Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF.
Immunology 1995;84(1):21-30.
1995: Fionula M Brennan; A P Cope; P Katsikis; D L Gibbons; Ravinder N Maini; Eugene Eyo Akujuru
Selective immunosuppression of tumour necrosis factor-alpha in rheumatoid arthritis.
Chemical immunology 1995;60():48-60.
1994: DM Butler; B Scallon; A Meager; M Kissonerghis; A Corcoran; Yuti Chernajovsky; Eugene Eyo Akujuru; J Ghrayeb; Fionula M Brennan
TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells.
Cytokine 1994;6(6):616-23.
1994: Ravinder N Maini; M Elliott; Fionula M Brennan; R O Williams; Eugene Eyo Akujuru
Targeting TNF alpha for the therapy of rheumatoid arthritis.
Clinical and experimental rheumatology 1994;12 Suppl 11():S63-6.
1994: DM Butler; Eugene Eyo Akujuru; F Di Padova; Fionula M Brennan
p55 and p75 tumor necrosis factor receptors are expressed and mediate common functions in synovial fibroblasts and other fibroblasts.
European cytokine network 1994;5(5):441-8.
1994: D L Gibbons; M Rowe; A P Cope; Eugene Eyo Akujuru; Fionula M Brennan
Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines.
European journal of immunology 1994;24(8):1879-85.
1994: A P Cope; Marco Londei; N R Chu; Shara Cohen; M J Elliott; Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.
The Journal of clinical investigation 1994;94(2):749-60.
1994: P D Katsikis; Cong-Qiu Chu; Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
Immunoregulatory role of interleukin 10 in rheumatoid arthritis.
The Journal of experimental medicine 1994;179(5):1517-27.
1993: M J Elliott; Ravinder N Maini; Eugene Eyo Akujuru; A Long-Fox; P Charles; P Katsikis; Fionula M Brennan; J Walker; H Bijl; J Ghrayeb
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
Arthritis and rheumatism 1993;36(12):1681-90.
1993: M Kristensen; Cong-Qiu Chu; D J Eedy; Eugene Eyo Akujuru; Fionula M Brennan; S M Breathnach
Localization of tumour necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor.
Clinical and experimental immunology 1993;94(2):354-62.
1993: A P Cope; D L Gibbons; D Aderka; Brian M J Foxwell; David Wallach; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.
Cytokine 1993;5(3):205-12.
1993: Ravinder N Maini; Fionula M Brennan; R Williams; Cong-Qiu Chu; A P Cope; D Gibbons; M Elliott; Eugene Eyo Akujuru
TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.
Clinical and experimental rheumatology 1993;11 Suppl 8():S173-5.
1992: Bent Deleuran; Cong-Qiu Chu; M Field; Fionula M Brennan; P Katsikis; Eugene Eyo Akujuru; Ravinder N Maini
Localization of interleukin-1 alpha, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage/pannus junction in rheumatoid arthritis.
British journal of rheumatology 1992;31(12):801-9.
1992: M Kristensen; Bent Deleuran; D J Eedy; M Feldmann; S M Breathnach; Fionula M Brennan
Distribution of interleukin 1 receptor antagonist protein (IRAP), interleukin 1 receptor, and interleukin 1 alpha in normal and psoriatic skin. Decreased expression of IRAP in psoriatic lesional epidermis.
The British journal of dermatology 1992;127(4):305-11.
1992: Bent Deleuran; Cong-Qiu Chu; M Field; Fionula M Brennan; T Mitchell; Eugene Eyo Akujuru; Ravinder N Maini
Localization of tumor necrosis factor receptors in the synovial tissue and cartilage-pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor alpha.
Arthritis and rheumatism 1992;35(10):1170-8.
1992: A P Cope; D Aderka; M Doherty; Hartmut Engelmann; D Gibbons; A C Jones; Fionula M Brennan; Ravinder N Maini; David Wallach; Eugene Eyo Akujuru
Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases.
Arthritis and rheumatism 1992;35(10):1160-9.
1992: Fionula M Brennan; D L Gibbons; T Mitchell; A P Cope; Ravinder N Maini; Eugene Eyo Akujuru
Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints.
European journal of immunology 1992;22(7):1907-12.
1992: Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
TNF alpha--a pivotal role in rheumatoid arthritis?
British journal of rheumatology 1992;31(5):293-8.
1992: Eugene Eyo Akujuru; Fionula M Brennan; Richard O Williams; A P Cope; D L Gibbons; P D Katsikis; Ravinder N Maini
Evaluation of the role of cytokines in autoimmune disease: the importance of TNF alpha in rheumatoid arthritis.
Progress in growth factor research 1992;4(3):247-55.
1991: C Haworth; Fionula M Brennan; David Chantry; M Turner; Ravinder N Maini; Eugene Eyo Akujuru
Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha.
European journal of immunology 1991;21(10):2575-9.
1991: M Turner; David Chantry; P Katsikis; A Berger; Fionula M Brennan; Eugene Eyo Akujuru
Induction of the interleukin 1 receptor antagonist protein by transforming growth factor-beta.
European journal of immunology 1991;21(7):1635-9.
1991: Eugene Eyo Akujuru; Fionula M Brennan; David Chantry; C Haworth; M Turner; P Katsikis; Marco Londei; E Abney; G Buchan; K Barrett
Cytokine assays: role in evaluation of the pathogenesis of autoimmunity.
Immunological reviews 1991;119():105-23.
1991: Fionula M Brennan; M Field; Cong-Qiu Chu; Eugene Eyo Akujuru; Ravinder N Maini
Cytokine expression in rheumatoid arthritis.
British journal of rheumatology 1991;30 Suppl 1():76-80.
1990: Fionula M Brennan; C O Zachariae; David Chantry; C G Larsen; M Turner; Ravinder N Maini; K Matsushima; Eugene Eyo Akujuru
Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells.
European journal of immunology 1990;20(9):2141-4.
1990: Fionula M Brennan; David Chantry; M Turner; B Foxwell; R Maini; M Feldmann
Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: lack of effect on spontaneous cytokine production in joint cell cultures.
Clinical and experimental immunology 1990;81(2):278-85.
1990: Ravinder N Maini; C Plater-Zyberk; C M Brown; S Aghamohammadi; Fionula M Brennan; Eugene Eyo Akujuru
CD5+B cells in rheumatoid arthritis and Sjögren's syndrome.
Clinical and experimental rheumatology 1990;8 Suppl 5():67-8.
1990: Eugene Eyo Akujuru; Fionula M Brennan; David Chantry; C Haworth; M Turner; E Abney; G Buchan; K Barrett; D Barkley; A Chu
Cytokine production in the rheumatoid joint: implications for treatment.
Annals of the rheumatic diseases 1990;49 Suppl 1():480-6.
1989: M Field; R D Melsom; Fionula M Brennan; david williams; L Schreiber; Desmond A McCarthy; Ravinder N Maini; R D Nelsom
Rapid clearance of the lupus antigen Sm is delayed by autoantibody: a possible mechanism of autoimmunity perpetuation.
Clinical and experimental immunology 1989;78(3):460-4.
1989: Fionula M Brennan; David Chantry; andrew jackson; Ravinder N Maini; Eugene Eyo Akujuru
Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis.
Lancet 1989;2(8657):244-7.
1989: Fionula M Brennan; David Chantry; andrew jackson; Ravinder N Maini; Eugene Eyo Akujuru
Cytokine production in culture by cells isolated from the synovial membrane.
Journal of autoimmunity 1989;2 Suppl():177-86.
1989: C Plater-Zyberk; Fionula M Brennan; Eugene Eyo Akujuru; Ravinder N Maini
'Fetal-type' B and T lymphocytes in rheumatoid arthritis and primary Sjögren's syndrome.
Journal of autoimmunity 1989;2 Suppl():233-41.
1988: Fionula M Brennan; Marco Londei; andrew jackson; T Hercend; M B Brenner; Ravinder N Maini; Eugene Eyo Akujuru
T cells expressing gamma delta chain receptors in rheumatoid arthritis.
Journal of autoimmunity 1988;1(4):319-26.
1988: Fionula M Brennan; E M Andrew; david williams; Ravinder N Maini
Anti-nRNP anti-nuclear antibody-secreting cells are represented in the B-lymphocyte repertoire of normal and MRL/MP-lpr/lpr lupus mice.
Immunology 1988;63(2):213-7.
1987: M Field; Fionula M Brennan; D McCarthy; P Mumford; Ravinder N Maini
MRL-lpr/lpr mice show an impairment of IgG aggregate removal which relates to parameters of disease activity.
Immunology 1987;61(4):463-7.
1985: M Field; Fionula M Brennan; R D Melsom; D McCarthy; P Mumford; Ravinder N Maini
MRL mice show an age-related impairment of IgG aggregate removal from the circulation.
Clinical and experimental immunology 1985;61(1):195-202.