Jeffrey Wrana

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Physiology

Chemicals & Drugs

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Eberhard Yanina; McDermott Sean P; Wang Xiaoming; Gronda Marcela; Venugopal Amudha; Wood Tabitha E; Hurren Rose; Datti Alessandro; Batey Robert A; Wrana Jeffrey; Antholine William E; Dick John; Schimmer Aaron D
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Viloria-Petit Alicia M; David Laurent; Jia Jun Yong; Erdemir Tuba; Bane Anita L; Pinnaduwage Dushanthi; Roncari Luba; Narimatsu Masahiro; Bose Rohit; Moffat Jason; Wong John W; Kerbel Robert S; O'Malley Frances P; Andrulis Irene L; Wrana Jeffrey L
A role for the TGFbeta-Par6 polarity pathway in breast cancer progression.
Sopko Richelle; Silva Elizabeth; Clayton Lesley; Gardano Laura; Barrios-Rodiles Miriam; Wrana Jeff; Varelas Xaralabos; Arbouzova Natalia I; Shaw Sanjeev; Saburi Sakura; Matakatsu Hitoshi; Blair Seth; McNeill Helen
Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown.

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All Publications

2009: Eberhard Yanina; McDermott Sean P; Wang Xiaoming; Gronda Marcela; Venugopal Amudha; Wood Tabitha E; Hurren Rose; Datti Alessandro; Batey Robert A; Wrana Jeffrey; Antholine William E; Dick John; Schimmer Aaron D
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Blood 2009;114(14):3064-73.
2009: Viloria-Petit Alicia M; David Laurent; Jia Jun Yong; Erdemir Tuba; Bane Anita L; Pinnaduwage Dushanthi; Roncari Luba; Narimatsu Masahiro; Bose Rohit; Moffat Jason; Wong John W; Kerbel Robert S; O'Malley Frances P; Andrulis Irene L; Wrana Jeffrey L
A role for the TGFbeta-Par6 polarity pathway in breast cancer progression.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):14028-33.
2009: Sopko Richelle; Silva Elizabeth; Clayton Lesley; Gardano Laura; Barrios-Rodiles Miriam; Wrana Jeff; Varelas Xaralabos; Arbouzova Natalia I; Shaw Sanjeev; Saburi Sakura; Matakatsu Hitoshi; Blair Seth; McNeill Helen
Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown.
Current biology : CB 2009;19(13):1112-7.
2009: Luga Valbona; McLean Sarah; Le Roy Christine; O'Connor-McCourt Maureen; Wrana Jeffrey L; Di Guglielmo Gianni M
The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning.
The Biochemical journal 2009;421(1):119-31.
2009: Narimatsu Masahiro; Bose Rohit; Pye Melanie; Zhang Liang; Miller Bryan; Ching Peter; Sakuma Rui; Luga Valbona; Roncari Luba; Attisano Liliana; Wrana Jeffrey L
Regulation of planar cell polarity by Smurf ubiquitin ligases.
Cell 2009;137(2):295-307.
2009: Simpson Craig D; Mawji Imtiaz A; Anyiwe Kika; Williams Moyo A; Wang Xiaoming; Venugopal Amudha L; Gronda Marcela; Hurren Rose; Cheng Sonia; Serra Stefano; Zavareh Reza Beheshti; Datti Alessandro; Wrana Jeffrey L; Ezzat Shereen; Schimmer Aaron D
Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.
Cancer research 2009;69(7):2739-47.
2009: Taylor Ian W; Linding Rune; Warde-Farley David; Liu Yongmei; Pesquita Catia; Faria Daniel; Bull Shelley; Pawson Tony; Morris Quaid; Wrana Jeffrey L
Dynamic modularity in protein interaction networks predicts breast cancer outcome.
Nature biotechnology 2009;27(2):199-204.
2009: MacNeil Lesley T; Hardy W Rod; Pawson Tony; Wrana Jeffrey L; Culotti Joseph G
UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.
Nature neuroscience 2009;12(2):150-5.
2009: Wrana Jeffrey L
The secret life of Smad4.
Cell 2009;136(1):13-4.
2009: Braun Pascal; Tasan Murat; Dreze Matija; Barrios-Rodiles Miriam; Lemmens Irma; Yu Haiyuan; Sahalie Julie M; Murray Ryan R; Roncari Luba; de Smet Anne-Sophie; Venkatesan Kavitha; Rual Jean-François; Vandenhaute Jean; Cusick Michael E; Pawson Tony; Hill David E; Tavernier Jan; Wrana Jeffrey L; Roth Frederick P; Vidal Marc
An experimentally derived confidence score for binary protein-protein interactions.
Nature methods 2009;6(1):91-7.
2009: Miller Bryan W; Lau Garnet; Grouios Chris; Mollica Emanuela; Barrios-Rodiles Miriam; Liu Yongmei; Datti Alessandro; Morris Quaid; Wrana Jeffrey L; Attisano Liliana
Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway.
Molecular systems biology 2009;5():315.
2008: Zavareh Reza Beheshti; Lau Ken S; Hurren Rose; Datti Alessandro; Ashline David J; Gronda Marcela; Cheung Pam; Simpson Craig D; Liu Wei; Wasylishen Amanda R; Boutros Paul C; Shi Hui; Vengopal Amudha; Jurisica Igor; Penn Linda Z; Reinhold Vern N; Ezzat Shereen; Wrana Jeff; Rose David R; Schachter Harry; Dennis James W; Schimmer Aaron D
Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function.
Cancer research 2008;68(16):6688-97.
2008: Mao Xinliang; Liang Sheng-ben; Hurren Rose; Gronda Marcela; Chow Sue; Xu G Wei; Wang Xiaoming; Zavareh Reza Beheshti; Jamal Nazir; Messner Hans; Hedley David W; Datti Alessandro; Wrana Jeff L; Zhu Yuanxiao; Shi Chang-xin; Lee Kyle; Tiedemann Rodger; Trudel Suzanne; Stewart A Keith; Schimmer Aaron D
Cyproheptadine displays preclinical activity in myeloma and leukemia.
Blood 2008;112(3):760-9.
2008: Varelas Xaralabos; Sakuma Rui; Samavarchi-Tehrani Payman; Peerani Raheem; Rao Balaji M; Dembowy Joanna; Yaffe Michael B; Zandstra Peter W; Wrana Jeffrey L
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
Nature cell biology 2008;10(7):837-48.
2008: Townsend Todd A; Wrana Jeffrey L; Davis George E; Barnett Joey V
Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA.
The Journal of biological chemistry 2008;283(20):13834-41.
2008: Taylor Ian W; Wrana Jeffrey L
SnapShot: The TGFbeta pathway interactome.
Cell 2008;133(2):378.e1.
2008: To Ciric; Kulkarni Sarang; Pawson Tony; Honda Tadashi; Gribble Gordon W; Sporn Michael B; Wrana Jeffrey L; Di Guglielmo Gianni M
The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex.
The Journal of biological chemistry 2008;283(17):11700-13.
2008: Silvestri Cristoforo; Narimatsu Masahiro; von Both Ingo; Liu Yongmei; Tan Nicholas B J; Izzi Luisa; McCaffery Peter; Wrana Jeffrey L; Attisano Liliana
Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development.
Developmental cell 2008;14(3):411-23.
2008: Xu G Wei; Mawji Imtiaz A; Macrae Chloe J; Koch C Anne; Datti Alessandro; Wrana Jeffrey L; Dennis James W; Schimmer Aaron D
A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization.
Apoptosis : an international journal on programmed cell death 2008;13(3):413-22.
2008: Groppe Jay; Hinck Cynthia S; Samavarchi-Tehrani Payman; Zubieta Chloe; Schuermann Jonathan P; Taylor Alexander B; Schwarz Patricia M; Wrana Jeffrey L; Hinck Andrew P
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.
Molecular cell 2008;29(2):157-68.
2007: Mao Xinliang; Stewart A Keith; Hurren Rose; Datti Alessandro; Zhu Xuegong; Zhu Yuanxiao; Shi Changxin; Lee Kyle; Tiedemann Rodger; Eberhard Yanina; Trudel Suzanne; Liang Shengben; Corey Seth J; Gillis Lisa C; Barber Dwayne L; Wrana Jeffery L; Ezzat Shereen; Schimmer Aaron D
A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin.
Blood 2007;110(12):4047-54.
2007: Fujisawa Kazuko; Wrana Jeffrey L; Culotti Joseph G
The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans.
Science (New York, N.Y.) 2007;317(5846):1934-8.
2007: Mawji Imtiaz A; Simpson Craig D; Gronda Marcela; Williams Moyo A; Hurren Rose; Henderson Clare J; Datti Alessandro; Wrana Jeffrey L; Schimmer Aaron D
A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis.
Cancer research 2007;67(17):8307-15.
2007: Wiesner Silke; Ogunjimi Abiodun A; Wang Hong-Rui; Rotin Daniela; Sicheri Frank; Wrana Jeffrey L; Forman-Kay Julie D
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.
Cell 2007;130(4):651-62.
2007: Izzi Luisa; Silvestri Cristoforo; von Both Ingo; Labbé Etienne; Zakin Lise; Wrana Jeffrey L; Attisano Liliana
Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development.
The EMBO journal 2007;26(13):3132-43.
2007: Savas Sevtap; Taylor Ian W; Wrana Jeff L; Ozcelik Hilmi
Functional nonsynonymous single nucleotide polymorphisms from the TGF-beta protein interaction network.
Physiological genomics 2007;29(2):109-17.
2007: Gumienny Tina L; MacNeil Lesley T; Wang Huang; de Bono Mario; Wrana Jeffrey L; Padgett Richard W
Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans.
Current biology : CB 2007;17(2):159-64.
2006: Chong P Andrew; Lin Hong; Wrana Jeffrey L; Forman-Kay Julie D
An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2.
The Journal of biological chemistry 2006;281(25):17069-75.
2006: Park Hyun-Joo; Partridge Emily; Cheung Pam; Pawling Judy; Donovan Rob; Wrana Jeffrey L; Dennis James W
Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth.
Cancer research 2006;66(7):3558-66.
2006: Bose Rohit; Wrana Jeffrey L
Regulation of Par6 by extracellular signals.
Current opinion in cell biology 2006;18(2):206-12.
2006: Wang Hong-Rui; Ogunjimi Abiodun A; Zhang Yue; Ozdamar Barish; Bose Rohit; Wrana Jeffrey L
Degradation of RhoA by Smurf1 ubiquitin ligase.
Methods in enzymology 2006;406():437-47.
2005: Klüppel Michael; Wight Thomas N; Chan Christina; Hinek Aleksander; Wrana Jeffrey L
Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis.
Development (Cambridge, England) 2005;132(17):3989-4003.
2005: Varga Alison C; Wrana Jeffrey L
The disparate role of BMP in stem cell biology.
Oncogene 2005;24(37):5713-21.
2005: Ogunjimi Abiodun A; Briant Douglas J; Pece-Barbara Nadia; Le Roy Christine; Di Guglielmo Gianni M; Kavsak Peter; Rasmussen Richele K; Seet Bruce T; Sicheri Frank; Wrana Jeffrey L
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain.
Molecular cell 2005;19(3):297-308.
2005: Le Roy Christine; Wrana Jeffrey L
Signaling and endocytosis: a team effort for cell migration.
Developmental cell 2005;9(2):167-8.
2005: Pece-Barbara Nadia; Vera Sonia; Kathirkamathamby Kirishanthy; Liebner Stefan; Di Guglielmo Gianni M; Dejana Elisabetta; Wrana Jeffrey L; Letarte Michelle
Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway.
The Journal of biological chemistry 2005;280(30):27800-8.
2005: Barrios-Rodiles Miriam; Brown Kevin R; Ozdamar Barish; Bose Rohit; Liu Zhong; Donovan Robert S; Shinjo Fukiko; Liu Yongmei; Dembowy Joanna; Taylor Ian W; Luga Valbona; Przulj Natasa; Robinson Mark; Suzuki Harukazu; Hayashizaki Yoshihide; Jurisica Igor; Wrana Jeffrey L
High-throughput mapping of a dynamic signaling network in mammalian cells.
Science (New York, N.Y.) 2005;307(5715):1621-5.
2005: Ozdamar Barish; Bose Rohit; Barrios-Rodiles Miriam; Wang Hong-Rui; Zhang Yue; Wrana Jeffrey L
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.
Science (New York, N.Y.) 2005;307(5715):1603-9.
2005: Le Roy Christine; Wrana Jeffrey L
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
Nature reviews. Molecular cell biology 2005;6(2):112-26.
2005: Klüppel Michael; Wrana Jeffrey L
Turning it up a Notch: cross-talk between TGF beta and Notch signaling.
BioEssays : news and reviews in molecular, cellular and developmental biology 2005;27(2):115-8.
2004: Lee-Hoeflich Si Tuen; Causing Carrie G; Podkowa Monika; Zhao Xin; Wrana Jeffrey L; Attisano Liliana
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis.
The EMBO journal 2004;23(24):4792-801.
2004: Lickert Heiko; Takeuchi Jun K; Von Both Ingo; Walls Johnathon R; McAuliffe Fionnuala; Adamson S Lee; Henkelman R Mark; Wrana Jeffrey L; Rossant Janet; Bruneau Benoit G
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.
Nature 2004;432(7013):107-12.
2004: Partridge Emily A; Le Roy Christine; Di Guglielmo Gianni M; Pawling Judy; Cheung Pam; Granovsky Maria; Nabi Ivan R; Wrana Jeffrey L; Dennis James W
Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.
Science (New York, N.Y.) 2004;306(5693):120-4.
2004: Swallow Carol J; Partridge Emily A; Macmillan Jennifer C; Tajirian Tania; DiGuglielmo Gianni M; Hay Kazy; Szweras Melanie; Jahnen-Dechent Willi; Wrana Jeff L; Redston Mark; Gallinger Steven; Dennis James W
alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression.
Cancer research 2004;64(18):6402-9.
2004: von Both Ingo; Silvestri Cristoforo; Erdemir Tuba; Lickert Heiko; Walls Johnathon R; Henkelman R Mark; Rossant Janet; Harvey Richard P; Attisano Liliana; Wrana Jeffrey L
Foxh1 is essential for development of the anterior heart field.
Developmental cell 2004;7(3):331-45.
2004: Le Roy Christine; Wrana Jeffrey L
Cell biology: an unexpected social servant.
Nature 2004;431(7005):142.
2004: Chong P Andrew; Ozdamar Barish; Wrana Jeffrey L; Forman-Kay Julie D
Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity.
The Journal of biological chemistry 2004;279(39):40707-14.
2004: Kimura Yuki; Jones Nina; Klüppel Michael; Hirashima Masanori; Tachibana Kazunobu; Cohn Jason B; Wrana Jeffrey L; Pawson Tony; Bernstein Alan
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6015-20.
2004: Zhang Yue; Wang Hong-Rui; Wrana Jefferey L
Smurf1: a link between cell polarity and ubiquitination.
Cell cycle (Georgetown, Tex.) 2004;3(4):391-2.
2003: Wang Hong-Rui; Zhang Yue; Ozdamar Barish; Ogunjimi Abiodun A; Alexandrova Evguenia; Thomsen Gerald H; Wrana Jeffrey L
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation.
Science (New York, N.Y.) 2003;302(5651):1775-9.
2003: Xiao Changchun; Shim Jae-hyuck; Klüppel Michael; Zhang Samuel Shao-Min; Dong Chen; Flavell Richard A; Fu Xin-Yuan; Wrana Jeffrey L; Hogan Brigid L M; Ghosh Sankar
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
Genes & development 2003;17(23):2933-49.
2003: Subramaniam V; Li H; Wong M; Kitching R; Attisano L; Wrana J; Zubovits J; Burger A M; Seth A
The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.
British journal of cancer 2003;89(8):1538-44.
2003: Rebbapragada A; Benchabane H; Wrana J L; Celeste A J; Attisano L
Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis.
Molecular and cellular biology 2003;23(20):7230-42.
2003: Benchabane Hassina; Wrana Jeffrey L
GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations.
Molecular and cellular biology 2003;23(18):6646-61.
2003: Reguly Teresa; Wrana Jeffrey L
In or out? The dynamics of Smad nucleocytoplasmic shuttling.
Trends in cell biology 2003;13(5):216-20.
2003: Di Guglielmo Gianni M; Le Roy Christine; Goodfellow Anne F; Wrana Jeffrey L
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.
Nature cell biology 2003;5(5):410-21.
2002: Wrana Jeffrey L
Structural biology: On the wings of inhibition.
Nature 2002;420(6916):613-4.
2002: Klüppel Michael; Vallis Katherine A; Wrana Jeffrey L
A high-throughput induction gene trap approach defines C4ST as a target of BMP signaling.
Mechanisms of development 2002;118(1-2):77-89.
2002: Takaku Kazuaki; Wrana Jeffrey L; Robertson Elizabeth J; Taketo Makoto M
No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice.
Cancer research 2002;62(16):4558-61.
2002: Attisano Liliana; Wrana Jeffrey L
Signal transduction by the TGF-beta superfamily.
Science (New York, N.Y.) 2002;296(5573):1646-7.
2002: Panopoulou Ekaterini; Gillooly David J; Wrana Jeffrey L; Zerial Marino; Stenmark Harald; Murphy Carol; Fotsis Theodore
Early endosomal regulation of Smad-dependent signaling in endothelial cells.
The Journal of biological chemistry 2002;277(20):18046-52.
2002: Wrana Jeffrey L
Phosphoserine-dependent regulation of protein-protein interactions in the Smad pathway.
Structure (London, England : 1993) 2002;10(1):5-7.
2002: Mehra Arun; Wrana Jeffrey L
TGF-beta and the Smad signal transduction pathway.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(5):605-22.
2001: Stroschein S L; Bonni S; Wrana J L; Luo K
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.
Genes & development 2001;15(21):2822-36.
2001: Bonni S; Wang H R; Causing C G; Kavsak P; Stroschein S L; Luo K; Wrana J L
TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.
Nature cell biology 2001;3(6):587-95.
2001: Hoodless P A; Pye M; Chazaud C; Labbé E; Attisano L; Rossant J; Wrana J L
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.
Genes & development 2001;15(10):1257-71.
2000: Kavsak P; Rasmussen R K; Causing C G; Bonni S; Zhu H; Thomsen G H; Wrana J L
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.
Molecular cell 2000;6(6):1365-75.
2000: Hua X; Miller Z A; Benchabane H; Wrana J L; Lodish H F
Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-beta-induced transcription of the Smad7 gene.
The Journal of biological chemistry 2000;275(43):33205-8.
2000: Attisano L; Wrana J L
Smads as transcriptional co-modulators.
Current opinion in cell biology 2000;12(2):235-43.
2000: Wrana J L
Crossing Smads.
Science's STKE : signal transduction knowledge environment 2000;2000(23):re1.
2000: Wrana J L; Attisano L
The Smad pathway.
Cytokine & growth factor reviews 2000;11(1-2):5-13.
2000: Wrana J L
Regulation of Smad activity.
Cell 2000;100(2):189-92.
2000: Sirard C; Kim S; Mirtsos C; Tadich P; Hoodless P A; Itié A; Maxson R; Wrana J L; Mak T W
Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.
The Journal of biological chemistry 2000;275(3):2063-70.
2000: Gupta I R; Macias-Silva M; Kim S; Zhou X; Piscione T D; Whiteside C; Wrana J L; Rosenblum N D
BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis.
Journal of cell science 2000;113 Pt 2():269-78.
2000: Wu G; Chen Y G; Ozdamar B; Gyuricza C A; Chong P A; Wrana J L; Massagué J; Shi Y
Structural basis of Smad2 recognition by the Smad anchor for receptor activation.
Science (New York, N.Y.) 2000;287(5450):92-7.
2000: Mehra A; Attisano L; Wrana J L
Characterization of Smad phosphorylation and Smad-receptor interaction.
Methods in molecular biology (Clifton, N.J.) 2000;142():67-78.
1999: Gupta I R; Piscione T D; Grisaru S; Phan T; Macias-Silva M; Zhou X; Whiteside C; Wrana J L; Rosenblum N D
Protein kinase A is a negative regulator of renal branching morphogenesis and modulates inhibitory and stimulatory bone morphogenetic proteins.
The Journal of biological chemistry 1999;274(37):26305-14.
1999: Zhu H; Kavsak P; Abdollah S; Wrana J L; Thomsen G H
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.
Nature 1999;400(6745):687-93.
1999: Hoodless P A; Tsukazaki T; Nishimatsu S; Attisano L; Wrana J L; Thomsen G H
Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus.
Developmental biology 1999;207(2):364-79.
1999: Brummel T; Abdollah S; Haerry T E; Shimell M J; Merriam J; Raftery L; Wrana J L; O'Connor M B
The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development.
Genes & development 1999;13(1):98-111.
1998: Tsukazaki T; Chiang T A; Davison A F; Attisano L; Wrana J L
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.
Cell 1998;95(6):779-91.
1998: Macías-Silva M; Hoodless P A; Tang S J; Buchwald M; Wrana J L
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.
The Journal of biological chemistry 1998;273(40):25628-36.
1998: Labbé E; Silvestri C; Hoodless P A; Wrana J L; Attisano L
Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2.
Molecular cell 1998;2(1):109-20.
1998: Tang S J; Hoodless P A; Lu Z; Breitman M L; McInnes R R; Wrana J L; Buchwald M
The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development.
Development (Cambridge, England) 1998;125(10):1877-87.
1998: Attisano L; Wrana J L
Mads and Smads in TGF beta signalling.
Current opinion in cell biology 1998;10(2):188-94.
1998: Waldrip W R; Bikoff E K; Hoodless P A; Wrana J L; Robertson E J
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.
Cell 1998;92(6):797-808.
1998: Hoodless P A; Wrana J L
Mechanism and function of signaling by the TGF beta superfamily.
Current topics in microbiology and immunology 1998;228():235-72.
1997: Piscione T D; Yager T D; Gupta I R; Grinfeld B; Pei Y; Attisano L; Wrana J L; Rosenblum N D
BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis.
The American journal of physiology 1997;273(6 Pt 2):F961-75.
1997: Pece N; Vera S; Cymerman U; White R I; Wrana J L; Letarte M
Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative.
The Journal of clinical investigation 1997;100(10):2568-79.
1997: Abdollah S; Macías-Silva M; Tsukazaki T; Hayashi H; Attisano L; Wrana J L
TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.
The Journal of biological chemistry 1997;272(44):27678-85.
1997: Li M; Li J; Hoodless P A; Tzukazaki T; Wrana J L; Attisano L; Tsang B K
Mothers against decapentaplegic-related protein 2 expression in avian granulosa cells is up-regulated by transforming growth factor beta during ovarian follicular development.
Endocrinology 1997;138(9):3659-65.
1997: Newfeld S J; Mehra A; Singer M A; Wrana J L; Attisano L; Gelbart W M
Mothers against dpp participates in a DDP/TGF-beta responsive serine-threonine kinase signal transduction cascade.
Development (Cambridge, England) 1997;124(16):3167-76.
1997: Hayashi H; Abdollah S; Qiu Y; Cai J; Xu Y Y; Grinnell B W; Richardson M A; Topper J N; Gimbrone M A; Wrana J L; Falb D
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.
Cell 1997;89(7):1165-73.
1996: Wrana J L; Attisano L
MAD-related proteins in TGF-beta signalling.
Trends in genetics : TIG 1996;12(12):493-6.
1996: Attisano L; Wrana J L
Signal transduction by members of the transforming growth factor-beta superfamily.
Cytokine & growth factor reviews 1996;7(4):327-39.
1996: Macías-Silva M; Abdollah S; Hoodless P A; Pirone R; Attisano L; Wrana J L
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling.
Cell 1996;87(7):1215-24.
1996: Holley S A; Neul J L; Attisano L; Wrana J L; Sasai Y; O'Connor M B; De Robertis E M; Ferguson E L
The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor.
Cell 1996;86(4):607-17.
1996: Eppert K; Scherer S W; Ozcelik H; Pirone R; Hoodless P; Kim H; Tsui L C; Bapat B; Gallinger S; Andrulis I L; Thomsen G H; Wrana J L; Attisano L
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
Cell 1996;86(4):543-52.
1996: Hoodless P A; Haerry T; Abdollah S; Stapleton M; O'Connor M B; Attisano L; Wrana J L
MADR1, a MAD-related protein that functions in BMP2 signaling pathways.
Cell 1996;85(4):489-500.
1996: Attisano L; Wrana J L; Montalvo E; Massagué J
Activation of signalling by the activin receptor complex.
Molecular and cellular biology 1996;16(3):1066-73.
1995: Vivien D; Wrana J L
Ligand-induced recruitment and phosphorylation of reduced TGF-beta type I receptor.
Experimental cell research 1995;221(1):60-5.
1995: Wieser R; Wrana J L; Massagué J
GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.
The EMBO journal 1995;14(10):2199-208.
1995: Vivien D; Attisano L; Wrana J L; Massagué J
Signaling activity of homologous and heterologous transforming growth factor-beta receptor kinase complexes.
The Journal of biological chemistry 1995;270(13):7134-41.
1995: Letsou A; Arora K; Wrana J L; Simin K; Twombly V; Jamal J; Staehling-Hampton K; Hoffmann F M; Gelbart W M; Massagué J
Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family.
Cell 1995;80(6):899-908.
1995: Manova K; De Leon V; Angeles M; Kalantry S; Giarré M; Attisano L; Wrana J; Bachvarova R F
mRNAs for activin receptors II and IIB are expressed in mouse oocytes and in the epiblast of pregastrula and gastrula stage mouse embryos.
Mechanisms of development 1995;49(1-2):3-11.
1994: Ventura F; Doody J; Liu F; Wrana J L; Massagué J
Reconstitution and transphosphorylation of TGF-beta receptor complexes.
The EMBO journal 1994;13(23):5581-9.
1994: Wrana J L; Attisano L; Wieser R; Ventura F; Massagué J
Mechanism of activation of the TGF-beta receptor.
Nature 1994;370(6488):341-7.
1994: Brummel T J; Twombly V; Marqués G; Wrana J L; Newfeld S J; Attisano L; Massagué J; O'Connor M B; Gelbart W M
Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila.
Cell 1994;78(2):251-61.
1994: Penton A; Chen Y; Staehling-Hampton K; Wrana J L; Attisano L; Szidonya J; Cassill J A; Massagué J; Hoffmann F M
Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor.
Cell 1994;78(2):239-50.
1994: Cárcamo J; Weis F M; Ventura F; Wieser R; Wrana J L; Attisano L; Massagué J
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.
Molecular and cellular biology 1994;14(6):3810-21.
1994: Massagué J; Attisano L; Wrana J L
The TGF-beta family and its composite receptors.
Trends in cell biology 1994;4(5):172-8.
1994: Attisano L; Wrana J L; López-Casillas F; Massagué J
TGF-beta receptors and actions.
Biochimica et biophysica acta 1994;1222(1):71-80.
1994: Wrana J L; Tran H; Attisano L; Arora K; Childs S R; Massagué J; O'Connor M B
Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.
Molecular and cellular biology 1994;14(2):944-50.
1993: Wieser R; Attisano L; Wrana J L; Massagué J
Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region.
Molecular and cellular biology 1993;13(12):7239-47.
1993: Attisano L; Cárcamo J; Ventura F; Weis F M; Massagué J; Wrana J L
Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.
Cell 1993;75(4):671-80.
1993: Childs S R; Wrana J L; Arora K; Attisano L; O'Connor M B; Massagué J
Identification of a Drosophila activin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9475-9.
1993: Estevez M; Attisano L; Wrana J L; Albert P S; Massagué J; Riddle D L
The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development.
Nature 1993;365(6447):644-9.
1993: López-Casillas F; Wrana J L; Massagué J
Betaglycan presents ligand to the TGF beta signaling receptor.
Cell 1993;73(7):1435-44.
1992: Wrana J L; Attisano L; Cárcamo J; Zentella A; Doody J; Laiho M; Wang X F; Massagué J
TGF beta signals through a heteromeric protein kinase receptor complex.
Cell 1992;71(6):1003-14.
1992: Zhang Q; Wrana J L; Sodek J
Characterization of the promoter region of the porcine opn (osteopontin, secreted phosphoprotein 1) gene. Identification of positive and negative regulatory elements and a 'silent' second promoter.
European journal of biochemistry / FEBS 1992;207(2):649-59.
1992: Massagué J; Andres J; Attisano L; Cheifetz S; López-Casillas F; Ohtsuki M; Wrana J L
TGF-beta receptors.
Molecular reproduction and development 1992;32(2):99-104.
1992: Attisano L; Wrana J L; Cheifetz S; Massagué J
Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors.
Cell 1992;68(1):97-108.
1992: Heersche J N; Reimers S M; Wrana J L; Waye M M; Gupta A K
Changes in expression of alpha 1 type 1 collagen and osteocalcin mRNA in osteoblasts and odontoblasts at different stages of maturity as shown by in situ hybridization.
Proceedings of the Finnish Dental Society. Suomen Hammaslääkäriseuran toimituksia 1992;88 Suppl 1():173-82.
1992: Wrana J L; Cárcamo J; Attisano L; Cheifetz S; Zentella A; López-Casillas F; Massagué J
The type II TGF-beta receptor signals diverse responses in cooperation with the type I receptor.
Cold Spring Harbor symposia on quantitative biology 1992;57():81-6.
1991: Overall C M; Wrana J L; Sodek J
Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression.
The Journal of biological chemistry 1991;266(21):14064-71.
1991: Kasugai S; Zhang Q; Overall C M; Wrana J L; Butler W T; Sodek J
Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter.
Bone and mineral 1991;13(3):235-50.
1991: Overall C M; Wrana J L; Sodek J
Induction of formative and resorptive cellular phenotypes in human gingival fibroblasts by TGF-beta 1 and concanavalin A: regulation of matrix metalloproteinases and TIMP.
Journal of periodontal research 1991;26(3 Pt 2):279-82.
1991: Wrana J L; Overall C M; Sodek J
Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor beta. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen.
European journal of biochemistry / FEBS 1991;197(2):519-28.
1991: Wrana J L; Kubota T; Zhang Q; Overall C M; Aubin J E; Butler W T; Sodek J
Regulation of transformation-sensitive secreted phosphoprotein (SPPI/osteopontin) expression by transforming growth factor-beta. Comparisons with expression of SPARC (secreted acidic cysteine-rich protein).
The Biochemical journal 1991;273 ( Pt 3)():523-31.
1990: Zhang Q; Domenicucci C; Goldberg H A; Wrana J L; Sodek J
Characterization of fetal porcine bone sialoproteins, secreted phosphoprotein I (SPPI, osteopontin), bone sialoprotein, and a 23-kDa glycoprotein. Demonstration that the 23-kDa glycoprotein is derived from the carboxyl terminus of SPPI.
The Journal of biological chemistry 1990;265(13):7583-9.
1989: Wrana J L; Zhang Q; Sodek J
Full length cDNA sequence of porcine secreted phosphoprotein-I (SPP-I, osteopontin).
Nucleic acids research 1989;17(23):10119.
1989: Overall C M; Wrana J L; Sodek J
Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta.
The Journal of biological chemistry 1989;264(3):1860-9.
1989: Overall C M; Wrana J L; Sodek J
Transforming growth factor-beta regulation of collagenase, 72 kDa-progelatinase, TIMP and PAI-1 expression in rat bone cell populations and human fibroblasts.
Connective tissue research 1989;20(1-4):289-94.
1988: Wrana J L; Maeno M; Hawrylyshyn B; Yao K L; Domenicucci C; Sodek J
Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations.
The Journal of cell biology 1988;106(3):915-24.
1987: Petkovich P M; Wrana J L; Grigoriadis A E; Heersche J N; Sodek J
1,25-Dihydroxyvitamin D3 increases epidermal growth factor receptors and transforming growth factor beta-like activity in a bone-derived cell line.
The Journal of biological chemistry 1987;262(28):13424-8.

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