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Lesley Wright

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TOP 3
A Rosemary Siafakas; Tania C Sorrell; Lesley C Wright; Christabel Wilson; Michelle Larsen; Ross Boadle; Peter R Williamson; Julianne T Djordjevic
Cell wall-linked cryptococcal phospholipase B1 is a source of secreted enzyme and a determinant of cell wall integrity.
Peter M Jones; Kylie M Turner; Julianne T Djordjevic; Tania C Sorrell; Lesley C Wright; Anthony M George
Role of conserved active site residues in catalysis by phospholipase B1 from Cryptococcus neoformans.
Daniel Obando; Fred Widmer; Lesley C Wright; Tania C Sorrell; Katrina A Jolliffe
Synthesis, antifungal and antimicrobial activity of alkylphospholipids.

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2007: A Rosemary Siafakas; Tania C Sorrell; Lesley C Wright; Christabel Wilson; Michelle Larsen; Ross Boadle; Peter R Williamson; Julianne T Djordjevic
Cell wall-linked cryptococcal phospholipase B1 is a source of secreted enzyme and a determinant of cell wall integrity.
The Journal of biological chemistry 2007;282(52):37508-14.
2007: Peter M Jones; Kylie M Turner; Julianne T Djordjevic; Tania C Sorrell; Lesley C Wright; Anthony M George
Role of conserved active site residues in catalysis by phospholipase B1 from Cryptococcus neoformans.
Biochemistry 2007;46(35):10024-32.
2007: Daniel Obando; Fred Widmer; Lesley C Wright; Tania C Sorrell; Katrina A Jolliffe
Synthesis, antifungal and antimicrobial activity of alkylphospholipids.
Bioorganic & medicinal chemistry 2007;15(15):5158-65.
2007: Zhongsheng Tong; Fred Widmer; Tania C Sorrell; Zofia Guse; Katrina A Jolliffe; Catriona Halliday; Ok Cha Lee; Fanrong Kong; Lesley C Wright; Sharon C A Chen
In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes.
Antimicrobial agents and chemotherapy 2007;51(6):2219-22.
2007: Clarissa K L Ng; Vatsala Singhal; Fred Widmer; Lesley C Wright; Tania C Sorrell; Katrina A Jolliffe
Synthesis, antifungal and haemolytic activity of a series of bis(pyridinium)alkanes.
Bioorganic & medicinal chemistry 2007;15(10):3422-9.
2007: Lesley C Wright; Rosemary M Santangelo; Ranjini Ganendren; Jackie Payne; Julianne T Djordjevic; Tania C Sorrell
Cryptococcal lipid metabolism: phospholipase B1 is implicated in transcellular metabolism of macrophage-derived lipids.
Eukaryotic cell 2007;6(1):37-47.
2006: Kylie M Turner; Lesley C Wright; Tania C Sorrell; Julianne T Djordjevic
N-linked glycosylation sites affect secretion of cryptococcal phospholipase B1, irrespective of glycosylphosphatidylinositol anchoring.
Biochimica et biophysica acta 2006;1760(10):1569-79.
2006: Tania C Sorrell; Lesley C Wright; Richard Malik; Uwe Himmelreich
Application of proton nuclear magnetic resonance spectroscopy to the study of Cryptococcus and cryptococcosis.
FEMS yeast research 2006;6(4):558-66.
2006: A Rosemary Siafakas; Lesley C Wright; Tania C Sorrell; Julianne T Djordjevic
Lipid rafts in Cryptococcus neoformans concentrate the virulence determinants phospholipase B1 and Cu/Zn superoxide dismutase.
Eukaryotic cell 2006;5(3):488-98.
2006: Fred Widmer; Lesley C Wright; Daniel Obando; Rosemary Handke; Ranjini Ganendren; David H Ellis; Tania C Sorrell
Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.
Antimicrobial agents and chemotherapy 2006;50(2):414-21.
2006: Clarissa K L Ng; Daniel Obando; Fred Widmer; Lesley C Wright; Tania C Sorrell; Katrina A Jolliffe
Correlation of antifungal activity with fungal phospholipase inhibition using a series of bisquaternary ammonium salts.
Journal of medicinal chemistry 2006;49(2):811-6.
2005: Julianne T Djordjevic; Maurizio Del Poeta; Tania C Sorrell; Kylie M Turner; Lesley C Wright
Secretion of cryptococcal phospholipase B1 (PLB1) is regulated by a glycosylphosphatidylinositol (GPI) anchor.
The Biochemical journal 2005;389(Pt 3):803-12.
2005: Rosemary T Santangelo; Sharon C A Chen; Tania C Sorrell; Lesley C Wright
Detection of antibodies to phospholipase B in patients infected with Cryptococcus neoformans by enzyme-linked immunosorbent assay (ELISA).
Medical mycology : official publication of the International Society for Human and Animal Mycology 2005;43(4):335-41.
2004: Lesley C Wright; Jackie Payne; Rosemary T Santangelo; Mukoma F Simpanya; Sharon C A Chen; Fred Widmer; Tania C Sorrell
Cryptococcal phospholipases: a novel lysophospholipase discovered in the pathogenic fungus Cryptococcus gattii.
The Biochemical journal 2004;384(Pt 2):377-84.
2004: Yun C Chang; Lesley C Wright; RL Tscharke; Tania C Sorrell; Christabel F Wilson; Kyung J Kwon-Chung
Regulatory roles for the homeodomain and C2H2 zinc finger regions of Cryptococcus neoformans Ste12alphap.
Molecular microbiology 2004;53(5):1385-96.
2003: John G S Coe; Christabel F Wilson; Tania C Sorrell; Nicolas G Latouche; Lesley C Wright
Cloning of CnLYSO1, a novel extracellular lysophospholipase of the pathogenic fungus Cryptococcus neoformans.
Gene 2003;316():67-78.
2003: Nalayini Sathasivam; Susan Brammah; Lesley C Wright; Edward Delikatny
Inhibition of tetraphenylphosphonium-induced NMR-visible lipid accumulation in human breast cells by chlorpromazine.
Biochimica et biophysica acta 2003;1633(3):149-60.
2003: Lesley C Wright; Julianne T Djordjevic; Stephen D Schibeci; Uwe Himmelreich; Nick Muljadi; Peter Williamson; Garry W Lynch
Detergent-resistant membrane fractions contribute to the total 1H NMR-visible lipid signal in cells.
European journal of biochemistry / FEBS 2003;270(9):2091-100.
2002: Lesley C Wright; Sharon C A Chen; Christabel F Wilson; Mukoma F Simpanya; Rebecca Blackstock; Gary M Cox; Juneann W Murphy; Tania C Sorrell
Strain-dependent effects of environmental signals on the production of extracellular phospholipase by Cryptococcus neoformans.
FEMS microbiology letters 2002;209(2):175-81.
2001: Gary M Cox; Henry C McDade; S C Chen; S C Tucker; Magnus Gottfredsson; Lesley C Wright; Tania C Sorrell; Steven D Leidich; Arturo Casadevall; Mahmoud A Ghannoum; John R Perfect
Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans.
Molecular microbiology 2001;39(1):166-75.
2000: Sharon C A Chen; Lesley C Wright; J C Golding; Tania C Sorrell
Purification and characterization of secretory phospholipase B, lysophospholipase and lysophospholipase/transacylase from a virulent strain of the pathogenic fungus Cryptococcus neoformans.
The Biochemical journal 2000;347(Pt 2):431-9.
2000: Lesley C Wright; K L Obbink; Edward Delikatny; Rosemary T Santangelo; Tania C Sorrell
The origin of 1H NMR-visible triacylglycerol in human neutrophils. Highfatty acid environments result in preferential sequestration of palmitic acid into plasma membrane triacylglycerol.
European journal of biochemistry / FEBS 2000;267(1):68-78.
1999: William A Bubb; Lesley C Wright; Michelle Cagney; Rosemary T Santangelo; Tania C Sorrell; Philip W Kuchel
Heteronuclear NMR studies of metabolites produced by Cryptococcus neoformans in culture media: identification of possible virulence factors.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1999;42(3):442-53.
1999: Rosemary T Santangelo; MH Nouri-Sorkhabi; Tania C Sorrell; Michelle Cagney; Sharon C A Chen; Philip W Kuchel; Lesley C Wright
Biochemical and functional characterisation of secreted phospholipase activities from Cryptococcus neoformans in their naturally occurring state.
Journal of medical microbiology 1999;48(8):731-40.
1997: G L May; Lesley C Wright; K G Obbink; P M Byleveld; M L Garg; Z I Ahmad; Tania C Sorrell
Increased saturated triacylglycerol levels in plasma membranes of human neutrophils stimulated by lipopolysaccharide.
Journal of lipid research 1997;38(8):1562-70.
1997: Sharon C A Chen; Michael Muller; J Z Zhou; Lesley C Wright; Tania C Sorrell
Phospholipase activity in Cryptococcus neoformans: a new virulence factor?
The Journal of infectious diseases 1997;175(2):414-20.
1997: Sharon C A Chen; Lesley C Wright; Rosemary T Santangelo; Michael Muller; V R Moran; Philip W Kuchel; Tania C Sorrell
Identification of extracellular phospholipase B, lysophospholipase, and acyltransferase produced by Cryptococcus neoformans.
Infection and immunity 1997;65(2):405-11.
1997: Lesley C Wright; MH Nouri-Sorkhabi; G L May; L S Danckwerts; Philip W Kuchel; Tania C Sorrell
Changes in cellular and plasma membrane phospholipid composition after lipopolysaccharide stimulation of human neutrophils, studied by 31P NMR.
European journal of biochemistry / FEBS 1997;243(1-2):328-35.
1996: MH Nouri-Sorkhabi; Lesley C Wright; D R Sullivan; Philip W Kuchel
Quantitative 31P nuclear magnetic resonance analysis of the phospholipids of erythrocyte membranes using detergent.
Lipids 1996;31(7):765-70.
1995: Lesley C Wright; S Chen; Basil D Roufogalis
Regulation of the activity and phosphorylation of the plasma membrane Ca(2+)-ATPase by adriamycin in intact human erythrocytes.
Archives of biochemistry and biophysics 1995;321(2):459-66.
1993: Lesley C Wright; S Chen; Basil D Roufogalis
Regulation of the activity and phosphorylation of the plasma membrane Ca(2+)-ATPase by protein kinase C in intact human erythrocytes.
Archives of biochemistry and biophysics 1993;306(1):277-84.
1991: Lesley C Wright; G L May; W B Mackinnon; P Gregory; K T Holmes; M Dyne; D Sullivan; Carolyn E Mountford
Tumour evolution in rats monitored by changes to serum and lipoproteins.
Invasion & metastasis 1991;11(6):332-47.
1989: Lesley C Wright; D R Sullivan; Michael Muller; M Dyne; M H Tattersall; Carolyn E Mountford
Elevated apolipoprotein(a) levels in cancer patients.
International journal of cancer. Journal international du cancer 1989;43(2):241-4.
1989: K T Holmes; M Dyne; P G Williams; G L May; E Tripp; Lesley C Wright; Carolyn E Mountford
Vinblastine sensitivity of leukaemic lymphoblasts modulated by serum lipid.
FEBS letters 1989;244(1):103-7.
1988: G L May; Lesley C Wright; M Dyne; W B Mackinnon; R M Fox; Carolyn E Mountford
Plasma membrane lipid composition of vinblastine sensitive and resistant human leukaemic lymphoblasts.
International journal of cancer. Journal international du cancer 1988;42(5):728-33.
1988: Lesley C Wright; G L May; P Gregory; M Dyne; K T Holmes; P G Williams; Carolyn E Mountford
Inhibition of metastatic potential by fucosidase: an NMR study identifies a cell surface metastasis marker.
Journal of cellular biochemistry 1988;37(1):49-59.
1988: C E Mountford; Lesley C Wright
Organization of lipids in the plasma membranes of malignant and stimulated cells: a new model.
Trends in biochemical sciences 1988;13(5):172-7.
1988: K T Holmes; W B Mackinnon; G L May; Lesley C Wright; M Dyne; M H Tattersall; Carolyn E Mountford; D Sullivan
Hyperlipidemia as a biochemical basis of magnetic resonance plasma test for cancer.
NMR in biomedicine 1988;1(1):44-9.
1987: Carolyn E Mountford; G L May; Lesley C Wright; W B Mackinnon; M Dyne; K T Holmes; C van Haaften-Day; M H Tattersall
Proteolipid identified by magnetic resonance spectroscopy in plasma of a patient with borderline ovarian tumour.
Lancet 1987;1(8537):829-34.
1986: Lesley C Wright; M Dyne; K T Holmes; T Romeo; Carolyn E Mountford
Cellular resistance to vinblastine is associated with altered respiratory function.
Biochemistry international 1986;13(2):295-305.
1986: Lesley C Wright; G L May; M Dyne; Carolyn E Mountford
A proteolipid in cancer cells is the origin of their high-resolution NMR spectrum.
FEBS letters 1986;203(2):164-8.
1986: K T Holmes; P G Williams; G L May; P Gregory; Lesley C Wright; M Dyne; Carolyn E Mountford
Cell surface involvement in cancer metastasis: an NMR study.
FEBS letters 1986;202(1):122-6.
1986: G L May; Lesley C Wright; K T Holmes; P G Williams; I C Smith; Peter Wright; R M Fox; Carolyn E Mountford
Assignment of methylene proton resonances in NMR spectra of embryonic and transformed cells to plasma membrane triglyceride.
The Journal of biological chemistry 1986;261(7):3048-53.
1985: Lesley C Wright; M Dyne; K T Holmes; Carolyn E Mountford
Phospholipid and ether linked phospholipid content alter with cellular resistance to vinblastine.
Biochemical and biophysical research communications 1985;133(2):539-45.
1985: P G Williams; M A Helmer; Lesley C Wright; M Dyne; R M Fox; K T Holmes; G L May; Carolyn E Mountford
Lipid domain in cancer cell plasma membrane shown by 1H NMR to be similar to a lipoprotein.
FEBS letters 1985;192(1):159-64.
1984: Carolyn E Mountford; Lesley C Wright; K T Holmes; W B Mackinnon; P Gregory; R M Fox
High-resolution proton nuclear magnetic resonance analysis of metastatic cancer cells.
Science (New York, N.Y.) 1984;226(4681):1415-8.