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Nicholas Wright

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TOP 3
Ann-Marie Baker; Trevor A Graham; Nicholas A Wright
Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development.
Anna M Nicholson; Marco Novelli; Manuel Rodriguez-Justo; Ashley Simpson; Nicholas A Wright; Nicola Burch; Trevor A Graham; Rebecca Harrison; Adam Humphries; Stuart A C McDonald; Janusz A Jankowski
Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor.
Naomi J Guppy; Rosemary E Jeffery; Hemant M Kocher; William R Otto; Richard Poulsom; Yassar A Qureshi; Nicholas A Wright; Mona E El-Bahrawy; Kornelia Fritsch; Malcolm R Alison
Trefoil factor family peptides in normal and diseased human pancreas.

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All Publications

2013: Ann-Marie Baker; Trevor A Graham; Nicholas A Wright
Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development.
The Journal of pathology 2013;229(4):502-14.
2012: Anna M Nicholson; Marco Novelli; Manuel Rodriguez-Justo; Ashley Simpson; Nicholas A Wright; Nicola Burch; Trevor A Graham; Rebecca Harrison; Adam Humphries; Stuart A C McDonald; Janusz A Jankowski
Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor.
Gut 2012;61(10):1380-9.
2012: Naomi J Guppy; Rosemary E Jeffery; Hemant M Kocher; William R Otto; Richard Poulsom; Yassar A Qureshi; Nicholas A Wright; Mona E El-Bahrawy; Kornelia Fritsch; Malcolm R Alison
Trefoil factor family peptides in normal and diseased human pancreas.
Pancreas 2012;41(6):888-96.
2012: Nicholas A Wright
Stem cell identification--in vivo lineage analysis versus in vitro isolation and clonal expansion.
The Journal of pathology 2012;227(3):255-66.
2012: Susan Galandiuk; Yong Cheng; George Elia; Rosemary Jeffery; Simon J Leedham; Stuart A C McDonald; Anna M Nicholson; Dahmane Oukrif; Manuel Rodriguez-Justo; Nicholas A Wright; Trevor A Graham
Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis.
Gastroenterology 2012;142(4):855-864.e8.
2011: Nadine T Gaisa; Trevor A Graham; Axel Heidenreich; Gerhard Jakse; Ruth Knuechel; Stuart Ac McDonald; Richard Poulsom; Nicholas A Wright
Clonal architecture of human prostatic epithelium in benign and malignant conditions.
The Journal of pathology 2011;225(2):172-80.
2011: Nadine T Gaisa; Trevor A Graham; Axel Heidenreich; Gerhard Jakse; Ruth Knuechel; Stuart A C McDonald; Richard Poulsom; Paul J Tadrous; Sagrario Cañadillas-Lopez; Nicholas A Wright
The human urothelium consists of multiple clonal units, each maintained by a stem cell.
The Journal of pathology 2011;225(2):163-71.
2011: Trevor A Graham; Stuart Ac McDonald; Nicholas A Wright
Field cancerization in the GI tract.
Future oncology (London, England) 2011;7(8):981-93.
2011: Lydia Gutierrez-Gonzalez; Trevor A Graham; Manuel Rodriguez-Justo; Simon J Leedham; Marco Novelli; Laura J Gay; Tania Ventayol-Garcia; Alicia Green; Ian Mitchell; David L Stoker; Sean L Preston; Shigeki Bamba; Eiji Yamada; Yuuki Kishi; Rebecca Harrison; Janusz A Jankowski; Nicholas A Wright; Stuart A C McDonald
The clonal origins of dysplasia from intestinal metaplasia in the human stomach.
Gastroenterology 2011;140(4):1251-1260.e1-6.
2011: Trevor A Graham; Adam Humphries; Theodore Sanders; Manuel Rodriguez-Justo; Paul J Tadrous; Sean L Preston; Marco Novelli; Simon J Leedham; Stuart A C McDonald; Nicholas A Wright
Use of methylation patterns to determine expansion of stem cell clones in human colon tissue.
Gastroenterology 2011;140(4):1241-1250.e1-9.
2011: Sebastian S Zeki; Trevor A Graham; Nicholas A Wright
Stem cells and their implications for colorectal cancer.
Nature reviews. Gastroenterology & hepatology 2011;8(2):90-100.
2011: Chung-Yin Lee; Malcolm R Alison; Gillian Hutchinson; Rosemary Jeffery; Richard Poulsom; Nicholas A Wright; William R Otto
Bone marrow cells in murine colitis: multi-signal analysis confirms pericryptal myofibroblast engraftment without epithelial involvement.
PloS one 2011;6(10):e26082.
2011: William R Otto; Nicholas A Wright
Mesenchymal stem cells: from experiment to clinic.
Fibrogenesis & tissue repair 2011;4():20.
2010: Malcolm R Alison; Shahriar Islam; Nicholas A Wright
Stem cells in cancer: instigators and propagators?
Journal of cell science 2010;123(Pt 14):2357-68.
2010: Trevor A Graham; Noor Jawad; Nicholas A Wright
Spindles losing their bearings: does disruption of orientation in stem cells predict the onset of cancer?
BioEssays : news and reviews in molecular, cellular and developmental biology 2010;32(6):468-72.
2010: Christina Thirlwell; Olivia C C Will; E Domingo; Trevor A Graham; Stuart A C McDonald; Dahmane Oukrif; Rosemary Jeffrey; Maggie Gorman; Manuel Rodriguez-Justo; Joanne Chin-Aleong; Susan Clark; Marco Novelli; Janusz A Jankowski; Nicholas A Wright; Ian P M Tomlinson; Simon J Leedham
Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.
Gastroenterology 2010;138(4):1441-54, 1454.e1-7.
2010: Wey-Ran Lin; Siew-Na Lim; Stuart A C McDonald; Trevor Graham; Victoria L Wright; Claire L Peplow; Adam Humphries; Hemant M Kocher; Nicholas A Wright; Amar P Dhillon; Malcolm R Alison
The histogenesis of regenerative nodules in human liver cirrhosis.
Hepatology (Baltimore, Md.) 2010;51(3):1017-26.
2010: Alan R Watson; Simon C Pitchford; Louise E Reynolds; Natalie Direkze; Mairi Brittan; Malcolm R Alison; Sara Rankin; Nicholas A Wright; Kairbaan M Hodivala-Dilke
Deficiency of bone marrow beta3-integrin enhances non-functional neovascularization.
The Journal of pathology 2010;220(4):435-45.
2010: Marco Nooteboom; Riem Johnson; Robert W Taylor; Nicholas A Wright; Robert N Lightowlers; Thomas B L Kirkwood; John C Mathers; Doug M Turnbull; Laura C Greaves
Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts.
Aging cell 2010;9(1):96-9.
2009: Stuart McDonald; Trevor A Graham; Stefanie Schier; Nicholas A Wright; Malcolm R Alison
Stem cells and solid cancers.
Virchows Archiv : an international journal of pathology 2009;455(1):1-13.
2009: Tariq G Fellous; Stuart McDonald; Julia Burkert; Adam Humphries; Shahriar Islam; Nemantha M W De-Alwis; Lydia Gutierrez-Gonzalez; Paul J Tadrous; George Elia; Hemant M Kocher; Satyajit Bhattacharya; Lisa Mears; Mona El-Bahrawy; Douglas M Turnbull; Robert W Taylor; Laura C Greaves; Patrick F Chinnery; Christopher P Day; Nicholas A Wright; Malcolm R Alison
A methodological approach to tracing cell lineage in human epithelial tissues.
Stem cells (Dayton, Ohio) 2009;27(6):1410-20.
2009: Tariq G Fellous; Shahriar Islam; Paul J Tadrous; George Elia; Hemant M Kocher; Satyajit Bhattacharya; Lisa Mears; Douglas M Turnbull; Robert W Taylor; Laura C Greaves; Patrick F Chinnery; Geoffery Taylor; Stuart A C McDonald; Nicholas A Wright; Stuart McDonald
Locating the stem cell niche and tracing hepatocyte lineages in human liver.
Hepatology (Baltimore, Md.) 2009;49(5):1655-63.
2009: Lydia Gutierrez-Gonzalez; Maesha Deheragoda; George Elia; Simon J Leedham; Arjun Shankar; Charles Imber; Janusz A Jankowski; Douglass M Turnbull; Marco Novelli; Nicholas A Wright; Stuart McDonald
Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations.
The Journal of pathology 2009;217(4):489-96.
2009: Simon J Leedham; Trevor A Graham; Dahmane Oukrif; Stuart McDonald; Manuel Rodriguez-Justo; Rebecca F Harrison; Neil A Shepherd; Marco Novelli; Janusz A Z Jankowski; Nicholas A Wright
Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.
Gastroenterology 2009;136(2):542-50.e6.
2009: Stefania Segditsas; Andrew J Rowan; Kimberley Howarth; Angela Jones; S Leedham; Nicholas A Wright; Patricia Gorman; W Chambers; E Domingo; Rebecca R Roylance; Elinor J Sawyer; Oliver Sieber; Ian P M Tomlinson
APC and the three-hit hypothesis.
Oncogene 2009;28(1):146-55.
2008: Simon J Leedham; S L Preston; S A C McDonald; George Elia; P Bhandari; D Poller; R Harrison; Marco Novelli; J A Jankowski; Nicholas A Wright
Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus.
Gut 2008;57(8):1041-8.
2008: L Gutiérrez-González; Nicholas A Wright
Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2008;40(7):510-22.
2008: Stuart McDonald; Laura C Greaves; Lydia Gutierrez-Gonzalez; Manuel Rodriguez-Justo; Maesha Deheragoda; Simon J Leedham; Robert W Taylor; Chung Yin Lee; Sean L Preston; Matthew Lovell; Toby Hunt; George Elia; Dahmane Oukrif; Rebecca Harrison; Marco Novelli; Ian Mitchell; David L Stoker; Douglass M Turnbull; Janusz A Jankowski; Nicholas A Wright
Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells.
Gastroenterology 2008;134(2):500-10.
2008: Sean L Preston; Simon J Leedham; Dahmane Oukrif; M Deheregoda; Robert A Goodlad; Richard Poulsom; Stuart McDonald; Nicholas A Wright; Marco Novelli
The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse.
The Journal of pathology 2008;214(3):294-301.
2008: Simon J Leedham; Nicholas A Wright
Expansion of a mutated clone: from stem cell to tumour.
Journal of clinical pathology 2008;61(2):164-71.
2007: Tzung-Hai Yen; Malcolm R Alison; H Terence Cook; Rosemary Jeffery; William R Otto; Nicholas A Wright; Richard Poulsom
The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment.
Cell proliferation 2007;40(2):143-56.
2007: Akira Andoh; Shigeki Bamba; Mairi Brittan; Yoshihide Fujiyama; Nicholas A Wright
Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut.
Pharmacology & therapeutics 2007;114(1):94-106.
2007: Mairi Brittan; Stuart McDonald; Stefanie Schier; Nicholas A Wright
Bone marrow stem cell-mediated regeneration in IBD: where do we go from here?
Gastroenterology 2007;132(3):1171-3.
2006: William R Otto; Ketan Patel; Iain McKinnell; Marissa D Evans; Chung-Yin Lee; David Frith; Sarah Hanrahan; Kenneth Blight; nikolaus blin; Tuncay Kayademir; Richard Poulsom; Rosemary Jeffery; Toby Hunt; Nicholas A Wright; Fiona McGregor; Karin A Oien
Identification of blottin: a novel gastric trefoil factor family-2 binding protein.
Proteomics 2006;6(15):4235-45.
2006: Stuart McDonald; Matthew J Lovell; Natalie C Direkze; Nicholas A Wright; Richard Poulsom
Stem cell plasticity and tumour formation.
European journal of cancer (Oxford, England : 1990) 2006;42(9):1247-56.
2006: Shigeki Bamba; C-Y Lee; Mairi Brittan; Sean L Preston; Natalie C Direkze; Richard Poulsom; Stuart McDonald; Nicholas A Wright; William R Otto
Bone marrow transplantation ameliorates pathology in interleukin-10 knockout colitic mice.
The Journal of pathology 2006;209(2):265-73.
2006: Stuart McDonald; Sean L Preston; Matthew J Lovell; Nicholas A Wright; Janusz A Jankowski
Mechanisms of disease: from stem cells to colorectal cancer.
Nature clinical practice. Gastroenterology & hepatology 2006;3(5):267-74.
2006: Stuart McDonald; Sean L Preston; Laura C Greaves; Simon J Leedham; Matthew A Lovell; Janusz A Jankowski; Douglass M Turnbull; Nicholas A Wright
Clonal expansion in the human gut: mitochondrial DNA mutations show us the way.
Cell cycle (Georgetown, Tex.) 2006;5(8):808-11.
2006: Stuart McDonald; Richard Poulsom; Mairi Brittan; Stefanie Schier; Julia Burkert; Nicholas A Wright
Isolation of gut SP cells does not automatically enrich for stem cells.
Gastroenterology 2006;130(3):1012-3; author reply 1013-4.
2006: Natalie C Direkze; Rosemary Jeffery; Kairbaan M Hodivala-Dilke; Toby Hunt; Raymond J Playford; George Elia; Richard Poulsom; Nicholas A Wright; Malcolm R Alison
Bone marrow-derived stromal cells express lineage-related messenger RNA species.
Cancer research 2006;66(3):1265-9.
2006: Pamela Vig; Francesco P Russo; Robert J Edwards; Paul J Tadrous; Nicholas A Wright; Howard Thomas; Stuart McDonald; Stuart J Forbes
The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice.
Hepatology (Baltimore, Md.) 2006;43(2):316-24.
2006: Simon J Leedham; Mairi Brittan; Sean L Preston; Stuart McDonald; Nicholas A Wright
The stomach periglandular fibroblast sheath: all present and correct.
Gut 2006;55(2):295-6.
2006: Laura C Greaves; Sean L Preston; Paul J Tadrous; Robert W Taylor; Martin J Barron; Dahmane Oukrif; Simon J Leedham; Maesha Deheragoda; Peter Sasieni; Marco Novelli; Janusz A Jankowski; Douglass M Turnbull; Nicholas A Wright; Stuart McDonald
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(3):714-9.
2006: Tzung-Hai Yen; Nicholas A Wright
The gastrointestinal tract stem cell niche.
Stem cell reviews 2006;2(3):203-12.
2006: Stuart McDonald; Mairi Brittan; Matthew J Lovell; Nicholas A Wright
Markers of adult tissue-based stem cells.
Handbook of experimental pharmacology 2006;(174):185-227.
2005: Akira Andoh; Shigeki Bamba; Yoshihide Fujiyama; Mairi Brittan; Nicholas A Wright
Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response.
Journal of gastroenterology 2005;40(12):1089-99.
2005: Simon J Leedham; Stefanie Schier; Andrew T Thliveris; Richard B Halberg; Michael A Newton; Nicholas A Wright
From gene mutations to tumours--stem cells in gastrointestinal carcinogenesis.
Cell proliferation 2005;38(6):387-405.
2005: Raffaele Del Buono; Chung Y Lee; Christopher J Hawkey; Nicholas A Wright
Isolated crypts form spheres prior to full intestinal differentiation when grown as xenografts: an in vivo model for the study of intestinal differentiation and crypt neogenesis, and for the abnormal crypt architecture of juvenile polyposis coli.
The Journal of pathology 2005;206(4):395-401.
2005: C Albera; Julia M Polak; S Janes; M J D Griffiths; Stuart McDonald; Nicholas A Wright; S Navaratnarasah; Richard Poulsom; Rosemary Jeffery; C Fisher; M Burke; Anne E Bishop
Repopulation of human pulmonary epithelium by bone marrow cells: a potential means to promote repair.
Tissue engineering 2005;11(7-8):1115-21.
2005: Mairi Brittan; Victoria Chance; George Elia; Richard Poulsom; Stuart McDonald; Thomas T MacDonald; Nicholas A Wright
A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts.
Gastroenterology 2005;128(7):1984-95.
2005: Te-Chao Fang; Stuart McDonald; H Terence Cook; Rosemary Jeffery; Nicholas A Wright; Richard Poulsom
Proliferation of bone marrow-derived cells contributes to regeneration after folic acid-induced acute tubular injury.
Journal of the American Society of Nephrology : JASN 2005;16(6):1723-32.
2005: Simon J Leedham; Andrew T Thliveris; Richard B Halberg; Michael A Newton; Nicholas A Wright
Gastrointestinal stem cells and cancer: bridging the molecular gap.
Stem cell reviews 2005;1(3):233-41.
2005: Stefanie Schier; Nicholas A Wright
Stem cell relationships and the origin of gastrointestinal cancer.
Oncology 2005;69 Suppl 1():9-13.
2005: Simon J Leedham; Mairi Brittan; Stuart McDonald; Nicholas A Wright
Intestinal stem cells.
Journal of cellular and molecular medicine 2005;9(1):11-24.
2005: Mairi Brittan; Kristin Braun; Louise E Reynolds; Francesco J Conti; Andrew R Reynolds; Richard Poulsom; Stuart McDonald; Nicholas A Wright; Kairbaan M Hodivala-Dilke
Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion.
The Journal of pathology 2005;205(1):1-13.
2004: Natalie C Direkze; Kairbaan M Hodivala-Dilke; Rosemary Jeffery; Toby Hunt; Richard Poulsom; Dahmane Oukrif; Stuart McDonald; Nicholas A Wright
Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts.
Cancer research 2004;64(23):8492-5.
2004: Te-Chao Fang; Stuart McDonald; Nicholas A Wright; Richard Poulsom
Adult stem cell plasticity: will engineered tissues be rejected?
International journal of experimental pathology 2004;85(3):115-24.
2004: Stuart J Forbes; Francesco P Russo; Virginia Rey; Marco Senzolo; Massimo Rugge; Nicholas A Wright; Stuart McDonald
A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis.
Gastroenterology 2004;126(4):955-63.
2004: Candice Roufosse; Natalie C Direkze; William R Otto; Nicholas A Wright
Circulating mesenchymal stem cells.
The international journal of biochemistry & cell biology 2004;36(4):585-97.
2004: Mairi Brittan; Nicholas A Wright
The gastrointestinal stem cell.
Cell proliferation 2004;37(1):35-53.
2004: Stuart McDonald; Richard Poulsom; William R Otto; Pamela Vig; Mairi Brittan; Natalie C Direkze; M Lovell; Te-Chao Fang; Sean L Preston; Nicholas A Wright
Recipes for adult stem cell plasticity: fusion cuisine or readymade?
Journal of clinical pathology 2004;57(2):113-20.
2003: Sean L Preston; Wai-Man Wong; Annie On-On Chan; Richard Poulsom; Rosemary Jeffery; Robert A Goodlad; Nikki Mandir; George Elia; Marco Novelli; Walter F Bodmer; Ian P M Tomlinson; Nicholas A Wright
Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.
Cancer research 2003;63(13):3819-25.
2003: Richard Poulsom; Stuart McDonald; Terry Cook; Rosemary Jeffery; Eoin Ryan; Stuart J Forbes; Toby Hunt; Susannah Wyles; Nicholas A Wright
Bone marrow stem cells contribute to healing of the kidney.
Journal of the American Society of Nephrology : JASN 2003;14 Suppl 1():S48-54.
2003: Sean L Preston; Stuart McDonald; Stuart J Forbes; Natalie C Direkze; Richard Poulsom; Nicholas A Wright
The new stem cell biology: something for everyone.
Molecular pathology : MP 2003;56(2):86-96.
2003: Stuart McDonald; Richard Poulsom; William R Otto; Pamela Vig; Mairi Brittan; Natalie C Direkze; Sean L Preston; Nicholas A Wright
Plastic adult stem cells: will they graduate from the school of hard knocks?
Journal of cell science 2003;116(Pt 4):599-603.
2003: Natalie C Direkze; Stuart J Forbes; Mairi Brittan; Toby Hunt; Rosemary Jeffery; Sean L Preston; Richard Poulsom; Kairbaan M Hodivala-Dilke; Stuart McDonald; Nicholas A Wright
Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice.
Stem cells (Dayton, Ohio) 2003;21(5):514-20.
2002: Stuart J Forbes; Pamela Vig; Richard Poulsom; Nicholas A Wright; Stuart McDonald
Adult stem cell plasticity: new pathways of tissue regeneration become visible.
Clinical science (London, England : 1979) 2002;103(4):355-69.
2002: Nicholas A Wright; R Poulsom
Top down or bottom up? Competing management structures in the morphogenesis of colorectal neoplasms.
Gut 2002;51(3):306-8.
2002: Mairi Brittan; Nicholas A Wright
Gastrointestinal stem cells.
The Journal of pathology 2002;197(4):492-509.
2002: Richard Poulsom; Stuart McDonald; Stuart J Forbes; Nicholas A Wright
Adult stem cell plasticity.
The Journal of pathology 2002;197(4):441-56.
2002: Stuart McDonald; Richard Poulsom; Stuart Forbes; Nicholas A Wright
An introduction to stem cells.
The Journal of pathology 2002;197(4):419-23.
2002: Mairi Brittan; Toby Hunt; Rosemary Jeffery; Richard Poulsom; Stuart J Forbes; Kairbaan M Hodivala-Dilke; J Goldman; Stuart McDonald; Nicholas A Wright
Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon.
Gut 2002;50(6):752-7.
2002: Stuart J Forbes; R Poulsom; Nicholas A Wright
Hepatic and renal differentiation from blood-borne stem cells.
Gene therapy 2002;9(10):625-30.
2002: M Sasaki; Anthony J FitzGerald; G Grant; Mohammad A Ghatei; Nicholas A Wright; Robert A Goodlad
Lectins can reverse the distal intestinal atrophy associated with elemental diets in mice.
Alimentary pharmacology & therapeutics 2002;16(3):633-42.
2002: W-M Wong; Nikki Mandir; Robert A Goodlad; Benjamin Chun-Yu Wong; SB Garcia; Shiu Kum Lam; Nicholas A Wright
Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fission.
Gut 2002;50(2):212-7.
2001: M Sasaki; Anthony J FitzGerald; Nikki Mandir; K Sasaki; Nicholas A Wright; Robert A Goodlad
Glicentin, an active enteroglucagon, has a significant trophic role on the small intestine but not on the colon in the rat.
Alimentary pharmacology & therapeutics 2001;15(10):1681-6.
2001: Richard Poulsom; Stuart J Forbes; Kairbaan M Hodivala-Dilke; E Ryan; S Wyles; S Navaratnarasah; Rosemary Jeffery; Toby Hunt; Stuart McDonald; T Cook; Charles D Pusey; Nicholas A Wright
Bone marrow contributes to renal parenchymal turnover and regeneration.
The Journal of pathology 2001;195(2):229-35.
2001: Nicholas A Wright
Interaction of trefoil family factors with mucins: clues to their mechanism of action?
Gut 2001;48(3):293-4.
2000: Stuart McDonald; Richard Poulsom; Rosemary Jeffery; A P Dhillon; A Quaglia; J Jacob; Marco Novelli; G Prentice; J Williamson; Nicholas A Wright
Hepatocytes from non-hepatic adult stem cells.
Nature 2000;406(6793):257.
2000: SB Garcia; M Novelli; Nicholas A Wright
The clonal origin and clonal evolution of epithelial tumours.
International journal of experimental pathology 2000;81(2):89-116.
2000: W M Wong; Gordon Stamp; G Elia; Richard Poulsom; Nicholas A Wright
Proliferative populations in intestinal metaplasia: evidence of deregulation in Paneth and goblet cells, but not endocrine cells.
The Journal of pathology 2000;190(1):107-13.
1999: Anthony J FitzGerald; Robert A Goodlad; Nicholas A Wright
GM food debate.
Lancet 1999;354(9191):1725-6; author reply 1726-7.
1999: Marco Novelli; Harpreet Wasan; I Rosewell; Julie Bee; Ian P M Tomlinson; Nicholas A Wright; Walter F Bodmer
Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12553-8.
1999: W M Wong; Nicholas A Wright
Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation.
JPEN. Journal of parenteral and enteral nutrition 1999;23(5 Suppl):S83-8.
1999: W M Wong; S B Garcia; Nicholas A Wright
Origins and morphogenesis of colorectal neoplasms.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999;107(6):535-44.
1999: W M Wong; Richard Poulsom; Nicholas A Wright
Trefoil peptides.
Gut 1999;44(6):890-5.
1999: W M Wong; Nicholas A Wright
Cell proliferation in gastrointestinal mucosa.
Journal of clinical pathology 1999;52(5):321-33.
1999: SB Garcia; H S Park; M Novelli; Nicholas A Wright
Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets.
The Journal of pathology 1999;187(1):61-81.
1998: Harpreet Wasan; H S Park; K C Liu; Nikki Mandir; A Winnett; P Sasieni; Walter F Bodmer; Robert A Goodlad; Nicholas A Wright
APC in the regulation of intestinal crypt fission.
The Journal of pathology 1998;185(3):246-55.
1998: JA Efstathiou; M Noda; A Rowan; C Dixon; R Chinery; Aida U Jawhari; T Hattori; Nicholas A Wright; Walter F Bodmer; Massimo Pignatelli
Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):3122-7.
1998: S Singh; Richard Poulsom; Andrew M Hanby; L A Rogers; Nicholas A Wright; M C Sheppard; M J Langman
Expression of oestrogen receptor and oestrogen-inducible genes pS2 and ERD5 in large bowel mucosa and cancer.
The Journal of pathology 1998;184(2):153-60.
1997: H S Park; Robert A Goodlad; Nicholas A Wright
The incidence of aberrant crypt foci and colonic carcinoma in dimethylhydrazine-treated rats varies in a site-specific manner and depends on tumor histology.
Cancer research 1997;57(20):4507-10.
1997: H S Park; Robert A Goodlad; D J Ahnen; A Winnett; Peter Sasieni; C Y Lee; Nicholas A Wright
Effects of epidermal growth factor and dimethylhydrazine on crypt size, cell proliferation, and crypt fission in the rat colon. Cell proliferation and crypt fission are controlled independently.
The American journal of pathology 1997;151(3):843-52.
1996: Nicholas A Wright
Migration of the ductular elements of gut-associated glands gives clues to the histogenesis of structures associated with responses to acid hypersecretory state: the origins of "gastric metaplasia" in the duodenum of the specialized mucosa of barrett's esophagus and of pseudopyloric metaplasia.
The Yale journal of biology and medicine 1996;69(2):147-53.
1996: Robert A Goodlad; Nicholas A Wright
Epidermal growth factor (EGF).
Baillière's clinical gastroenterology 1996;10(1):33-47.
1996: Robert A Goodlad; Nicholas A Wright
Clinical gastroenterology. Introduction.
Baillière's clinical gastroenterology 1996;10(1):ix-xii.
1996: W R Otto; J Rao; Helen M Cox; E Kotzian; C Y Lee; R A Goodlad; A Lane; M Gorman; Paul S Freemont; H F Hansen; D Pappin; Nicholas A Wright
Effects of pancreatic spasmolytic Polypeptide (PSP) on epithelial cell function.
European journal of biochemistry / FEBS 1996;235(1-2):64-72.
1995: H S Park; Robert A Goodlad; Nicholas A Wright
Crypt fission in the small intestine and colon. A mechanism for the emergence of G6PD locus-mutated crypts after treatment with mutagens.
The American journal of pathology 1995;147(5):1416-27.
1995: Robert A Goodlad; Nicholas A Wright
Epidermal growth factor and transforming growth factor-alpha actions on the gut.
European journal of gastroenterology & hepatology 1995;7(10):928-32.
1995: Robert A Goodlad; B Ratcliffe; C Y Lee; Nicholas A Wright
Dietary fibre and the gastrointestinal tract: differing trophic effects on muscle and mucosa of the stomach, small intestine and colon.
European journal of clinical nutrition 1995;49 Suppl 3():S178-81.
1995: Catherine Sarraf; Malcolm R Alison; T W Ansari; Nicholas A Wright
Subcellular distribution of peptides associated with gastric mucosal healing and neoplasia.
Microscopy research and technique 1995;31(3):234-47.
1995: Stuart McDonald; R Chinery; Richard Poulsom; Paul Ashwood; J M Longcroft; Nicholas A Wright
Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor and transforming growth factor alpha mRNAs in rat stomach.
The Journal of pathology 1995;175(4):405-14.
1994: G Elia; R Chinery; Andrew M Hanby; Richard Poulsom; Nicholas A Wright
The production and characterization of a new monoclonal antibody to the trefoil peptide human spasmolytic polypeptide.
The Histochemical journal 1994;26(8):644-7.
1994: D J Ahnen; Richard Poulsom; G W Stamp; G Elia; C Pike; R Jeffery; J Longcroft; M C Rio; P Chambon; Nicholas A Wright
The ulceration-associated cell lineage (UACL) reiterates the Brunner's gland differentiation programme but acquires the proliferative organization of the gastric gland.
The Journal of pathology 1994;173(4):317-26.
1994: J A Jankowski; Robert A Goodlad; Nicholas A Wright
Maintenance of normal intestinal mucosa: function, structure, and adaptation.
Gut 1994;35(1 Suppl):S1-4.
1993: Andrew M Hanby; Richard Poulsom; S Singh; G Elia; R E Jeffery; Nicholas A Wright
Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach.
Gastroenterology 1993;105(4):1110-6.
1993: Richard Poulsom; Nicholas A Wright
Trefoil peptides: a newly recognized family of epithelial mucin-associated molecules.
The American journal of physiology 1993;265(2 Pt 1):G205-13.
1993: Nicholas A Wright
Trefoil peptides and the gut.
Gut 1993;34(5):577-9.
1993: Andrew M Hanby; Richard Poulsom; G Elia; S Singh; J M Longcroft; Nicholas A Wright
The expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in 'gastric metaplasia' of the proximal duodenum: implications for the nature of 'gastric metaplasia'.
The Journal of pathology 1993;169(3):355-60.
1993: R Chinery; Richard Poulsom; G Elia; Andrew M Hanby; Nicholas A Wright
Expression and purification of a trefoil peptide motif in a beta-galactosidase fusion protein and its use to search for trefoil-binding sites.
European journal of biochemistry / FEBS 1993;212(2):557-63.
1993: Robert A Goodlad; C Y Lee; M R Alison; Catherine Sarraf; M A Ghatei; S R Bloom; Nicholas A Wright
Evaluation of a proposed technique to assess unscheduled DNA synthesis and genotoxicity.
Gut 1993;34(2):235-41.
1993: Nicholas A Wright; Richard Poulsom; Gordon Stamp; S Van Noorden; Catherine Sarraf; G Elia; D Ahnen; R Jeffery; J Longcroft; C Pike
Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease.
Gastroenterology 1993;104(1):12-20.
1993: Richard Poulsom; R Chinery; Catherine Sarraf; S Van Noorden; Gordon Stamp; EN Lalani; G Elia; Nicholas A Wright
Trefoil peptide gene expression in small intestinal Crohn's disease and dietary adaptation.
Journal of clinical gastroenterology 1993;17 Suppl 1():S78-91.
1992: J A Jankowski; Nicholas A Wright
Epithelial stem cells in gastrointestinal morphogenesis, adaptation and carcinogenesis.
Seminars in cell biology 1992;3(6):445-56.
1992: Robert A Goodlad; C Y Lee; Nicholas A Wright
Cell proliferation in the small intestine and colon of intravenously fed rats: effects of urogastrone-epidermal growth factor.
Cell proliferation 1992;25(5):393-404.
1992: G W Stamp; Richard Poulsom; L P Chung; Satish Keshav; R E Jeffery; J A Longcroft; M Pignatelli; Nicholas A Wright
Lysozyme gene expression in inflammatory bowel disease.
Gastroenterology 1992;103(2):532-8.
1992: R Chinery; Richard Poulsom; L A Rogers; R E Jeffery; J M Longcroft; Andrew M Hanby; Nicholas A Wright
Localization of intestinal trefoil-factor mRNA in rat stomach and intestine by hybridization in situ.
The Biochemical journal 1992;285 ( Pt 1)():5-8.
1992: S Levi; Robert A Goodlad; C Y Lee; Mark J Walport; Nicholas A Wright; Humphrey Hodgson
Effects of nonsteroidal anti-inflammatory drugs and misoprostol on gastroduodenal epithelial proliferation in arthritis.
Gastroenterology 1992;102(5):1605-11.
1992: K C Liu; Nicholas A Wright
The migration pathway of epithelial cells on human duodenal villi: the origin and fate of 'gastric metaplastic' cells in duodenal mucosa.
Epithelial cell biology 1992;1(2):53-8.
1992: R Del Buono; K A Fleming; A L Morey; P A Hall; Nicholas A Wright
A nude mouse xenograft model of fetal intestine development and differentiation.
Development (Cambridge, England) 1992;114(1):67-73.
1992: C M Quinn; Nicholas A Wright
The usefulness of clinical measurements of cell proliferation in gynecological cancer.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1992;11(2):131-43.
1992: S Levi; Robert A Goodlad; C Y Lee; G Stamp; Mark J Walport; Nicholas A Wright; Humphrey Hodgson
Non-steroidal anti-inflammatory drugs inhibit the processes of mucosal cell proliferation associated with duodenal ulcer healing.
Digestion 1992;53(3-4):129-33.
1992: Nicholas A Wright; Richard Poulsom; Gordon Stamp; S Van Norden; Catherine Sarraf; G Elia; D Ahnen; R Jeffery; J Longcroft; C Pike
Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease.
Scandinavian journal of gastroenterology. Supplement 1992;193():76-82.
1992: Robert A Goodlad; M A Ghatei; S R Bloom; S Levin; Nicholas A Wright
Plasma and tissue hormones in the dog after administration of the prostaglandin analogue, misoprostol.
Digestion 1992;53(1-2):1-7.
1991: Robert A Goodlad; S Levi; C Y Lee; Nikki Mandir; H Hodgson; Nicholas A Wright
Morphometry and cell proliferation in endoscopic biopsies: evaluation of a technique.
Gastroenterology 1991;101(5):1235-41.
1991: Robert A Goodlad; Nikki Mandir; S Levin; J L Allen; Nicholas A Wright
Prostaglandins and the colonic epithelium. Effects of misoprostol on crypt size, cell production, and cell migration in the dog.
Gastroenterology 1991;101(5):1229-34.
1991: Robert A Goodlad; M A Ghatei; S R Bloom; Nicholas A Wright
Glucagon 1-21 reduces intestinal epithelial cell proliferation in parenterally fed rats.
Experimental physiology 1991;76(6):943-9.
1991: S D Slater; M G Cook; C Fisher; Nicholas A Wright; C S Foster
A comparative study of proliferation indices and ploidy in dysplastic naevi and malignant melanomas using flow cytometry.
Histopathology 1991;19(4):337-44.
1991: R J Scott; P A Hall; J S Haldane; Susan Van Noorden; Y Price; D P Lane; Nicholas A Wright
A comparison of immunohistochemical markers of cell proliferation with experimentally determined growth fraction.
The Journal of pathology 1991;165(2):173-8.
1991: Robert A Goodlad; K B Raja; T J Peters; Nicholas A Wright
Effects of urogastrone-epidermal growth factor on intestinal brush border enzymes and mitotic activity.
Gut 1991;32(9):994-8.
1991: Robert A Goodlad; C Y Lee; S Levin; Nicholas A Wright
Effects of the prostaglandin analogue misoprostol on cell proliferation in the canine small intestine.
Experimental physiology 1991;76(4):561-6.
1991: John Calam; Robert A Goodlad; C Y Lee; B Ratcliffe; M E Coates; G W Stamp; Nicholas A Wright
Achlorhydria-induced hypergastrinaemia: the role of bacteria.
Clinical science (London, England : 1979) 1991;80(4):281-4.
1991: R Del Buono; Massimo Pignatelli; W F Bodmer; Nicholas A Wright
The role of the arginine-glycine-aspartic acid-directed cellular binding to type I collagen and rat mesenchymal cells in colorectal tumour differentiation.
Differentiation; research in biological diversity 1991;46(2):97-103.
1990: Nicholas A Wright; Richard Poulsom; G W Stamp; P A Hall; R E Jeffery; J M Longcroft; M C Rio; Catherine Tomasetto; P Chambon
Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues.
The Journal of pathology 1990;162(4):279-84.
1990: S Levi; Robert A Goodlad; C Y Lee; G Stamp; Mark J Walport; Nicholas A Wright; Humphrey Hodgson
Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing.
Lancet 1990;336(8719):840-3.
1990: M Thompson; K A Fleming; D J Evans; R Fundele; M A Surani; Nicholas A Wright
Gastric endocrine cells share a clonal origin with other gut cell lineages.
Development (Cambridge, England) 1990;110(2):477-81.
1990: Nicholas A Wright
Endocrine cells in non-endocrine tumours.
The Journal of pathology 1990;161(1):85-7.
1990: E M Thompson; Y E Price; Nicholas A Wright
Kinetics of enteroendocrine cells with implications for their origin: a study of the cholecystokinin and gastrin subpopulations combining tritiated thymidine labelling with immunocytochemistry in the mouse.
Gut 1990;31(4):406-11.
1990: C M Quinn; Nicholas A Wright
The clinical assessment of proliferation and growth in human tumours: evaluation of methods and applications as prognostic variables.
The Journal of pathology 1990;160(2):93-102.
1990: Nicholas A Wright; C M Pike; G Elia
Ulceration induces a novel epidermal growth factor-secreting cell lineage in human gastrointestinal mucosa.
Digestion 1990;46 Suppl 2():125-33.
1990: Robert A Goodlad; A J Madgwick; M R Moffatt; S Levin; J L Allen; Nicholas A Wright
The effects of the prostaglandin analogue, misoprostol, on cell proliferation and cell migration in the canine stomach.
Digestion 1990;46 Suppl 2():182-7.
1990: R A Goodlad; M A Ghatei; J Domin; S R Bloom; Nicholas A Wright
Is peptide YY trophic to the intestinal epithelium of parenterally fed rats?
Digestion 1990;46 Suppl 2():177-81.
1990: Robert A Goodlad; A J Madgwick; M R Moffatt; S Levin; J L Allen; Nicholas A Wright
Prostaglandins and the dog stomach: effects of misoprostol on the proportion of mucosa to muscle and on the proportion of different epithelial cell types.
Digestion 1990;45(4):212-6.
1990: Robert A Goodlad; A J Madgwick; M R Moffatt; S Levin; J L Allen; Nicholas A Wright
Effects of misoprostol on cell migration and transit in the dog stomach.
Gastroenterology 1990;98(1):90-5.
1990: Nicholas A Wright
DNA synthesis and genotoxicity.
Digestion 1990;47 Suppl 1():24-30; discussion 49-52.
1989: Nicholas A Wright; J Carter; M Irwin
The measurement of villus cell population size in the mouse small intestine in normal and abnormal states: a comparison of absolute measurements with morphometric estimators in sectioned immersion-fixed material.
Cell and tissue kinetics 1989;22(6):425-50.
1989: S M Kaftan; Nicholas A Wright
Studies on the mechanisms of mucous cell depletion in experimental colitis.
The Journal of pathology 1989;159(1):75-85.
1989: Robert A Goodlad; B Ratcliffe; J P Fordham; Mohammad A Ghatei; J Domin; Stephen R Bloom; Nicholas A Wright
Plasma enteroglucagon, gastrin and peptide YY in conventional and germ-free rats refed with a fibre-free or fibre-supplemented diet.
Quarterly journal of experimental physiology (Cambridge, England) 1989;74(4):437-42.
1989: Robert A Goodlad; B Ratcliffe; J P Fordham; Nicholas A Wright
Does dietary fibre stimulate intestinal epithelial cell proliferation in germ free rats?
Gut 1989;30(6):820-5.
1989: Robert A Goodlad; H Gregory; Nicholas A Wright
Is polyamine synthesis involved in the proliferative response of the intestinal epithelium to urogastrone-epidermal growth factor?
Clinical science (London, England : 1979) 1989;76(6):595-8.
1989: Robert A Goodlad; A J Madgwick; M R Moffatt; S Levin; J L Allen; Nicholas A Wright
Prostaglandins and the gastric epithelium: effects of misoprostol on gastric epithelial cell proliferation in the dog.
Gut 1989;30(3):316-21.
1988: Gordon Stamp; A Quaba; A Braithwaite; Nicholas A Wright
Basal cell carcinoma xenografts in nude mice: studies on epithelial differentiation and stromal relationships.
The Journal of pathology 1988;156(3):213-25.
1988: Robert A Goodlad; A P Savage; W Lenton; Mohammad A Ghatei; H Gregory; Stephen R Bloom; Nicholas A Wright
Does resection enhance the response of the intestine to urogastrone-epidermal growth factor in the rat?
Clinical science (London, England : 1979) 1988;75(2):121-6.
1988: Robert A Goodlad; J A Plumb; Nicholas A Wright
Epithelial cell proliferation and intestinal absorptive function during starvation and refeeding in the rat.
Clinical science (London, England : 1979) 1988;74(3):301-6.
1987: I W Thompson; D W Day; Nicholas A Wright
Subnuclear vacuolated mucous cells: a novel abnormality of simple mucin-secreting cells of non-specialized gastric mucosa and Brunner's glands.
Histopathology 1987;11(10):1067-81.
1987: Robert A Goodlad; T J Wilson; W Lenton; H Gregory; K G McCullagh; Nicholas A Wright
Intravenous but not intragastric urogastrone-EGF is trophic to the intestine of parenterally fed rats.
Gut 1987;28(5):573-82.
1987: Robert A Goodlad; W Lenton; Mohammad A Ghatei; T E Adrian; Stephen R Bloom; Nicholas A Wright
Effects of an elemental diet, inert bulk and different types of dietary fibre on the response of the intestinal epithelium to refeeding in the rat and relationship to plasma gastrin, enteroglucagon, and PYY concentrations.
Gut 1987;28(2):171-80.
1987: Robert A Goodlad; J A Plumb; Nicholas A Wright
Simultaneous measurement of intestinal crypt cell production rate and water absorption.
Gut 1987;28 Suppl():189-92.
1987: Robert A Goodlad; T J Wilson; W Lenton; H Gregory; K G McCullagh; Nicholas A Wright
Proliferative effects of urogastrone-EGF on the intestinal epithelium.
Gut 1987;28 Suppl():37-43.
1987: Robert A Goodlad; W Lenton; Mohammad A Ghatei; T E Adrian; Stephen R Bloom; Nicholas A Wright
Proliferative effects of 'fibre' on the intestinal epithelium: relationship to gastrin, enteroglucagon and PYY.
Gut 1987;28 Suppl():221-6.
1985: A P Savage; G E Gornacz; T E Adrian; Mohammad A Ghatei; Robert A Goodlad; Nicholas A Wright; Stephen R Bloom
Is raised plasma peptide YY after intestinal resection in the rat responsible for the trophic response?
Gut 1985;26(12):1353-8.
1985: Robert A Goodlad; T J Wilson; W Lenton; H Gregory; K G McCullough; Nicholas A Wright
Urogastrone-epidermal growth factor is trophic to the intestinal epithelium of parenterally fed rats.
Experientia 1985;41(9):1161-3.