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Patrick Brennan

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Hee Jin Kim; Kalyani Prithiviraj; Patrick J Brennan; Nathan A Groathouse; John S Spencer
Gene expression profile and immunological evaluation of unique hypothetical unknown proteins of Mycobacterium leprae by using quantitative real-time PCR.
Patrick J Brennan; Roland Brosch; Bruce Birren; Bruno Sobral
TBCAP; tuberculosis annotation project.
Amanda Nogueira Brum Fontes; Harrison Magdinier Gomes; Heitor de Sá Gonçalves; Flávio Alves Lara; Norma Lucena-Silva; Maria Manuela da Fonseca Moura; Maria Cristina Vidal Pessolani; Maria Araci de Andrade Pontes; Denise Silva Rezende; Euzenir N Sarno; Ida Maria Foschiani Dias Baptista; Patrick J Brennan; Varalakshmi D Vissa; Edson Cláudio Araripe de Albuquerque; Marcelo Ivens de Araujo; Philip N Suffys
Genotyping of Mycobacterium leprae present on Ziehl-Neelsen-stained microscopic slides and in skin biopsy samples from leprosy patients in different geographic regions of Brazil.

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All Publications

2013: Hee Jin Kim; Kalyani Prithiviraj; Patrick J Brennan; Nathan A Groathouse; John S Spencer
Gene expression profile and immunological evaluation of unique hypothetical unknown proteins of Mycobacterium leprae by using quantitative real-time PCR.
Clinical and vaccine immunology : CVI 2013;20(2):181-90.
2013: Patrick J Brennan; Roland Brosch; Bruce Birren; Bruno Sobral
TBCAP; tuberculosis annotation project.
Tuberculosis (Edinburgh, Scotland) 2013;93(1):1-5.
2012: Amanda Nogueira Brum Fontes; Harrison Magdinier Gomes; Heitor de Sá Gonçalves; Flávio Alves Lara; Norma Lucena-Silva; Maria Manuela da Fonseca Moura; Maria Cristina Vidal Pessolani; Maria Araci de Andrade Pontes; Denise Silva Rezende; Euzenir N Sarno; Ida Maria Foschiani Dias Baptista; Patrick J Brennan; Varalakshmi D Vissa; Edson Cláudio Araripe de Albuquerque; Marcelo Ivens de Araujo; Philip N Suffys
Genotyping of Mycobacterium leprae present on Ziehl-Neelsen-stained microscopic slides and in skin biopsy samples from leprosy patients in different geographic regions of Brazil.
Memórias do Instituto Oswaldo Cruz 2012;107 Suppl 1():143-9.
2012: John S Spencer; William H Wheat; Marivic F Balagon; Patrick J Brennan; Delphi Chatterjee; Malcolm Duthie; Annemieke Geluk; Mary Jackson; Hee Jin Kim; Jade N Kurihara; Wei Li; Armi Maghanoy; Irene Mallari; Paul Saunderson; Hazel M Dockrell
Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy.
Memórias do Instituto Oswaldo Cruz 2012;107 Suppl 1():79-89.
2012: Gérald Larrouy-Maumus; Jerome Nigou; Audrey Noguera; Ha Pham; Germain Puzo; Lucia Valentínová; Anne Drumond Villela; Sophie Zuberogoitia; Katarína Mikusová; Henrieta Škovierová; Shiva Kumar Angala; Patrick J Brennan; Rabeb Dhouib; Martine GILLERON; Jana Korduláková; Mary Jackson
A small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteria.
The Journal of biological chemistry 2012;287(47):39933-41.
2012: Anna E Grzegorzewicz; Vijay Gundi; Juan M Belardinelli; Sarah E M Born; Patrick J Brennan; Rebecca M Crew; Mamadou Daffé; Brigitte Gicquel; Victoria Jones; Jana Korduláková; Françoise Laval; Jan Madacki; Michael R McNeil; HECTOR MORBIDONI; Annaïk Quémard; Nawel Slama; Adrien Vaquié; Julien Vaubourgeix; Mary Jackson
A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone.
The Journal of biological chemistry 2012;287(46):38434-41.
2012: Jordi B Torrelles; Nannan Zhang; John T Belisle; Patrick J Brennan; Mark A Keen; Michael R McNeil; Robert L Modlin; Peter Allan Sieling; Delphi Chatterjee
Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells.
Glycobiology 2012;22(8):1118-27.
2012: Saioa Urresti; Mark J van der Woerd; David Albesa-Jové; Pedro M Alzari; Patrick J Brennan; Ana Carreras-González; Petra Gest; Mary Jackson; Devinder Kaur; Sonia López-Fernández; Ha T Pham; Francis Schaeffer; Marcelo E Guerin
Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.
The Journal of biological chemistry 2012;287(29):24649-61.
2012: Marcia V S B Martins; Maria Cristina Vidal Pessolani; Maria A A Pontes; John S Spencer; Jolien J van der Ploeg-van Schip; Tereza J P G Bandeira; Patrick J Brennan; Fernanda M Carvalho; Luciana S Costa; Janvier P de Morais; Annemieke Geluk; Heitor S Gonçalves; Marjorie M da S Guimarães; Mariana A V B Hacker; Geraldo Pereira
Pathogen-specific epitopes as epidemiological tools for defining the magnitude of Mycobacterium leprae transmission in areas endemic for leprosy.
PLoS neglected tropical diseases 2012;6(4):e1616.
2012: Benjawan Phetsuksiri; Janisara Rudeeaneksin; Rama Murthy Sakamuri; Sopa Srisungngam; Patrick J Brennan; Supranee Bunchoo; Atchariya Lukebua; Soontara Paitoon; Ruch Wongtrungkapun; Varalakshmi Vissa
SNP genotypes of Mycobacterium leprae isolates in Thailand and their combination with rpoT and TTC genotyping for analysis of leprosy distribution and transmission.
Japanese journal of infectious diseases 2012;65(1):52-6.
2012: Andrés Obregón-Henao; Blanca L Ortiz; Mauricio Rojas; Patrick J Brennan; María A Duque-Correa; Luis F García; John T Belisle
Stable extracellular RNA fragments of Mycobacterium tuberculosis induce early apoptosis in human monocytes via a caspase-8 dependent mechanism.
PloS one 2012;7(1):e29970.
2011: John S Spencer; Patrick J Brennan
The role of Mycobacterium leprae phenolic glycolipid I (PGL-I) in serodiagnosis and in the pathogenesis of leprosy.
Leprosy review 2011;82(4):344-57.
2011: Wei Li; Danielle E Lyons; Armi A Maghanoy; Irene B Mallari; Indira Nath; Florenda M Orcullo; Sakamuri Rama Murthy; Vidyagouri Shinde; Esterlina V Tan; Marivic Balagon; Patrick J Brennan; Edred Lao Dela Pena; Varalakshmi D Vissa
Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.
Antimicrobial agents and chemotherapy 2011;55(11):5384-7.
2011: Petronela Dianišková; Mary Jackson; Devinder Kaur; Jana Korduláková; Patrick J Brennan; Henrieta Skovierová; Katarína Mikušová
Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster.
General physiology and biophysics 2011;30(3):239-50.
2011: Reem Al-Mubarak; Marivic Balagon; Patrick J Brennan; Corey D Broeckling; Jason Vander Heiden; Varalakshmi D Vissa
Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis.
PLoS neglected tropical diseases 2011;5(9):e1303.
2011: Suresh Bhamidi; Patrick J Brennan; Dean Crick; Victoria Jones; John Belisle; Michael S Scherman; Michael R McNeil
Detailed structural and quantitative analysis reveals the spatial organization of the cell walls of in vivo grown Mycobacterium leprae and in vitro grown Mycobacterium tuberculosis.
The Journal of biological chemistry 2011;286(26):23168-77.
2011: Craig A Umscheid; Matthew D Mitchell; Jalpa A Doshi; Rajender Agarwal; Kendal Williams; Patrick J Brennan
Estimating the proportion of healthcare-associated infections that are reasonably preventable and the related mortality and costs.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 2011;32(2):101-14.
2011: John S Spencer; Hee Jin Kim; William H Wheat; Delphi Chatterjee; Marivic V Balagon; Roland V Cellona; Esterlina V Tan; Robert Gelber; Paul Saunderson; Malcolm S Duthie; Stephen T Reece; William Burman; Robert Belknap; William R Mac Kenzie; Annemieke Geluk; Linda Oskam; Hazel M Dockrell; Patrick J Brennan
Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy.
Clinical and vaccine immunology : CVI 2011;18(2):260-7.
2010: Henrieta Skovierová; Gérald Larrouy-Maumus; Ha Pham; Martina Belanová; Nathalie Barilone; Arunava Dasgupta; Katarína Mikusová; Brigitte Gicquel; Martine GILLERON; Patrick J Brennan; Germain Puzo; Jerome Nigou; Mary Jackson
Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis.
The Journal of biological chemistry 2010;285(53):41348-55.
2010: Craig A Umscheid; Kendal Williams; Patrick J Brennan
Hospital-based comparative effectiveness centers: translating research into practice to improve the quality, safety and value of patient care.
Journal of general internal medicine 2010;25(12):1352-5.
2010: Marcelo E Guerin; Jana Korduláková; Pedro Alzari; Patrick J Brennan; Mary Jackson
Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria.
The Journal of biological chemistry 2010;285(44):33577-83.
2010: Matthew D Mitchell; Kendal Williams; Patrick J Brennan; Craig A Umscheid
Integrating local data into hospital-based healthcare technology assessment: two case studies.
International journal of technology assessment in health care 2010;26(3):294-300.
2010: Jian Zhang; Delphi Chatterjee; Patrick J Brennan; John S Spencer; Avraham Liav
A modified synthesis and serological evaluation of neoglycoproteins containing the natural disaccharide of PGL-I from Mycobacterium leprae.
Bioorganic & medicinal chemistry letters 2010;20(11):3250-3.
2010: Craig A Umscheid; Rajender K Agarwal; Patrick J Brennan
Updating the guideline development methodology of the Healthcare Infection Control Practices Advisory Committee (HICPAC).
American journal of infection control 2010;38(4):264-73.
2010: prabagaran narayanasamy; HyungJin Eoh; Patrick J Brennan; Dean Crick
Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF.
Chemistry & biology 2010;17(2):117-22.
2009: HyungJin Eoh; prabagaran narayanasamy; Amanda C Brown; Tanya Parish; Patrick J Brennan; Dean Crick
Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens.
Chemistry & biology 2009;16(12):1230-9.
2009: Kara B Mascitti; Scott Manaker; Jeff Rohrbach; Patrick J Brennan; Neil O Fishman
Limitations in using aspiration pneumonia as a quality measure.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 2009;30(12):1233-5.
2009: Hataichanok Scherman; Devinder Kaur; Ha Pham; Henrieta Skovierová; Mary Jackson; Patrick J Brennan
Identification of a polyprenylphosphomannosyl synthase involved in the synthesis of mycobacterial mannosides.
Journal of bacteriology 2009;191(21):6769-72.
2009: Henrieta Skovierová; Gérald Larrouy-Maumus; Jian Zhang; Devinder Kaur; Nathalie Barilone; Jana Korduláková; Martine GILLERON; Stéphanie Guadagnini; Martina Belanová; Marie-Christine Prevost; Brigitte Gicquel; Germain Puzo; Delphi Chatterjee; Patrick J Brennan; Jerome Nigou; Mary Jackson
AftD, a novel essential arabinofuranosyltransferase from mycobacteria.
Glycobiology 2009;19(11):1235-47.
2009: Marcelo E Guerin; Devinder Kaur; B S Somashekar; Sara Gibbs; Petra Gest; Delphi Chatterjee; Patrick J Brennan; Mary Jackson
New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis.
The Journal of biological chemistry 2009;284(38):25687-96.
2009: Amanda Nogueira Brum Fontes; Sakamuri Rama Murthy; Ida Maria Foschiani Dias Baptista; Somei Ura; Milton O Moraes; Alejandra Nóbrega Martínez; Euzenir N Sarno; Patrick J Brennan; Varalakshmi D Vissa; Philip N Suffys
Genetic diversity of mycobacterium leprae isolates from Brazilian leprosy patients.
Leprosy review 2009;80(3):302-15.
2009: Sopa Srisungnam; Janisara Rudeeaneksin; Atchariya Lukebua; Sukanya Wattanapokayakit; Supanee Pasadorn; Krisada Mahotarn; Sakamuri Rama Murthy; Miyako Kimura; Patrick J Brennan; Benjawan Phetsuksiri; Varalakshmi D Vissa
Molecular epidemiology of leprosy based on VNTR typing in Thailand.
Leprosy review 2009;80(3):280-9.
2009: Sakamuri Rama Murthy; Jordan Harrison; Robert Gelber; Paul Saunderson; Patrick J Brennan; Marivic Balagon; Varalakshmi D Vissa
A continuation: study and characterisation of Mycobacterium leprae short tandem repeat genotypes and transmission of leprosy in Cebu, Philippines.
Leprosy review 2009;80(3):272-9.
2009: Rama Murthy Sakamuri; Miyako Kimura; Wei Li; Hyun-Chul Kim; Hyeyoung Lee; Madanahally D Kiran; William C Black; Marivic Balagon; Robert Gelber; Sang-Nae Cho; Patrick J Brennan; Varalakshmi D Vissa
Population-based molecular epidemiology of leprosy in Cebu, Philippines.
Journal of clinical microbiology 2009;47(9):2844-54.
2009: Leanne B Gasink; Patrick J Brennan
Isolation precautions for antibiotic-resistant bacteria in healthcare settings.
Current opinion in infectious diseases 2009;22(4):339-44.
2009: Miyako Kimura; Sakamuri Rama Murthy; Nathan A Groathouse; Becky L Rivoire; David Gingrich; Susan Krueger-Koplin; Sang-Nae Cho; Patrick J Brennan; Varalakshmi D Vissa
Rapid variable-number tandem-repeat genotyping for Mycobacterium leprae clinical specimens.
Journal of clinical microbiology 2009;47(6):1757-66.
2009: Varalakshmi D Vissa; Wei Li; Sakamuri Rama Murthy; Patrick J Brennan
Defining mycobacteria: Shared and specific genome features for different lifestyles.
Indian journal of microbiology 2009;49(1):11-47.
2009: Cristiana Soares de Lima; Maria A M Marques; Anne-Sophie Debrie; Elza C C Almeida; Carlos A M Silva; Patrick J Brennan; Euzenir N Sarno; Franco D Menozzi; Maria Cristina Vidal Pessolani
Heparin-binding hemagglutinin (HBHA) of Mycobacterium leprae is expressed during infection and enhances bacterial adherence to epithelial cells.
FEMS microbiology letters 2009;292(2):162-9.
2009: Annemieke Geluk; John S Spencer; Kidist Bobosha; Maria C V Pessolani; Geraldo Pereira; Sayera Banu; Nadine Honoré; Stephen T Reece; Murdo Macdonald; Bishwa Sapkota; Chaman Ranjit; Kees L M C Franken; Martha Zewdie; Abraham Aseffa; Rabia Hussain; Mariane M Stefani; Sang-Nae Cho; Linda Oskam; Patrick J Brennan; Hazel M Dockrell
From genome-based in silico predictions to ex vivo verification of leprosy diagnosis.
Clinical and vaccine immunology : CVI 2009;16(3):352-9.
2009: Mary Jackson; Patrick J Brennan
Polymethylated polysaccharides from Mycobacterium species revisited.
The Journal of biological chemistry 2009;284(4):1949-53.
2009: Devinder Kaur; Ha Pham; Gérald Larrouy-Maumus; Michel Rivière; Varalakshmi D Vissa; Marcelo E Guerin; Germain Puzo; Patrick J Brennan; Mary Jackson
Initiation of methylglucose lipopolysaccharide biosynthesis in mycobacteria.
PloS one 2009;4(5):e5447.
2009: HyungJin Eoh; Patrick J Brennan; Dean Crick
The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.
Tuberculosis (Edinburgh, Scotland) 2009;89(1):1-11.
2008: Petra Gest; Devinder Kaur; Ha T Pham; Mark van der Woerd; Emily Hansen; Patrick J Brennan; Mary Jackson; Marcelo E Guerin
Preliminary crystallographic analysis of GpgS, a key glucosyltransferase involved in methylglucose lipopolysaccharide biosynthesis in Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 12):1121-4.
2008: Devinder Kaur; Andrés Obregón-Henao; Ha Pham; Delphi Chatterjee; Patrick J Brennan; Mary Jackson
Lipoarabinomannan of Mycobacterium: mannose capping by a multifunctional terminal mannosyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17973-7.
2008: Jordi B Torrelles; Rose Knaup; Avina Kolareth; Tatiana Slepushkina; Thomas M Kaufman; Peter Kang; Preston J Hill; Patrick J Brennan; Delphi Chatterjee; John Belisle; James M Musser; Larry S Schlesinger
Identification of Mycobacterium tuberculosis clinical isolates with altered phagocytosis by human macrophages due to a truncated lipoarabinomannan.
The Journal of biological chemistry 2008;283(46):31417-28.
2008: Lorene R Martinez; Beth Harris; William C Black; Robert M Meyer; Patrick J Brennan; Varalakshmi D Vissa; Robert L Jones
Genotyping North American animal Mycobacterium bovis isolates using multilocus variable number tandem repeat analysis.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 2008;20(6):707-15.
2008: Janisara Rudeeaneksin; Sopa Srisungngam; Pathom Sawanpanyalert; Thaverit Sittiwakin; Sirirat Likanonsakul; Supannee Pasadorn; Prasit Palittapongarnpim; Patrick J Brennan; Benjawan Phetsuksiri
LightCycler real-time PCR for rapid detection and quantitation of Mycobacterium leprae in skin specimens.
FEMS immunology and medical microbiology 2008;54(2):263-70.
2008: Marc Monot; Nadine Honoré; Charlotte Balière; Baohong Ji; Samba Sow; Patrick J Brennan; Stewart T Cole
Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?
Journal of clinical microbiology 2008;46(7):2291-7.
2008: Maria Angela M Marques; Ana Gisele C Neves-Ferreira; Erika K Xavier da Silveira; Richard H Valente; Alex Chapeaurouge; Jonas Perales; Renato da Silva Bernardes; Karen M Dobos; John S Spencer; Patrick J Brennan; Maria Cristina Vidal Pessolani
Deciphering the proteomic profile of Mycobacterium leprae cell envelope.
Proteomics 2008;8(12):2477-91.
2008: Avraham Liav; Shiva K Angala; Patrick J Brennan; Mary Jackson
N-D-aldopentofuranosyl-N'-[p-(isoamyloxy)phenyl]-thiourea derivatives: potential anti-TB therapeutic agents.
Bioorganic & medicinal chemistry letters 2008;18(8):2649-51.
2008: Martina Belánová; Petronela Dianisková; Patrick J Brennan; Gladys Completo; Natisha L Rose; Todd L Lowary; Katarína Mikusová
Galactosyl transferases in mycobacterial cell wall synthesis.
Journal of bacteriology 2008;190(3):1141-5.
2008: Sebabrata Mahapatra; Dean Crick; Michael R McNeil; Patrick J Brennan
Unique structural features of the peptidoglycan of Mycobacterium leprae.
Journal of bacteriology 2008;190(2):655-61.
2007: HyungJin Eoh; Amanda C Brown; Lori Buetow; William N Hunter; Tanya Parish; Devinder Kaur; Patrick J Brennan; Dean Crick
Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development.
Journal of bacteriology 2007;189(24):8922-7.
2007: Alan G Wasserstein; Patrick J Brennan; Arthur H Rubenstein
Institutional leadership and faculty response: fostering professionalism at the University of Pennsylvania School of Medicine.
Academic medicine : journal of the Association of American Medical Colleges 2007;82(11):1049-56.
2007: Jana Korduláková; Yves L Janin; Avraham Liav; Nathalie Barilone; Tiago Dos Vultos; Jean Rauzier; Patrick J Brennan; Brigitte Gicquel; Mary Jackson
Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 2007;51(11):3824-9.
2007: Devinder Kaur; Michael R McNeil; Kay-Hooi Khoo; Delphi Chatterjee; Dean Crick; Mary Jackson; Patrick J Brennan
New insights into the biosynthesis of mycobacterial lipomannan arising from deletion of a conserved gene.
The Journal of biological chemistry 2007;282(37):27133-40.
2007: Eleanor Z Kincaid; Andrea J Wolf; Ludovic Desvignes; Sebabrata Mahapatra; Dean Crick; Patrick J Brennan; Martin S Pavelka; Joel D Ernst
Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3187-95.
2007: Xiaoman Weng; Zheng Wang; Jian Liu; Miyako Kimura; William C Black; Patrick J Brennan; Huanying Li; Varalakshmi D Vissa
Identification and distribution of Mycobacterium leprae genotypes in a region of high leprosy prevalence in China: a 3-year molecular epidemiological study.
Journal of clinical microbiology 2007;45(6):1728-34.
2007: Stefan Berg; Devinder Kaur; Mary Jackson; Patrick J Brennan
The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates.
Glycobiology 2007;17(6):35-56R.
2007: Marcia Valéria B S Martins; Monica C B S Lima; Nádia Cristina Duppre; Haroldo J Matos; John S Spencer; Patrick J Brennan; Euzenir N Sarno; Leila Fonseca; Geraldo Pereira; Maria Cristina Vidal Pessolani
The level of PPD-specific IFN-gamma-producing CD4+ T cells in the blood predicts the in vivo response to PPD.
Tuberculosis (Edinburgh, Scotland) 2007;87(3):202-11.
2007: Franck Biet; Maria Angela de Melo Marques; Maggy Grayon; Erika Kopp Xavier da Silveira; Patrick J Brennan; Hervé Drobecq; Dominique Raze; Maria Cristina Vidal Pessolani; Camille Locht; Franco D Menozzi
Mycobacterium smegmatis produces an HBHA homologue which is not involved in epithelial adherence.
Microbes and infection / Institut Pasteur 2007;9(2):175-82.
2007: Patrick J Brennan; Dean Crick
The cell-wall core of Mycobacterium tuberculosis in the context of drug discovery.
Current topics in medicinal chemistry 2007;7(5):475-88.
2006: Benjawan Phetsuksiri; Janisara Rudeeaneksin; Prapaporn Supapkul; Suksawat Wachapong; Krisada Mahotarn; Patrick J Brennan
A simplified reverse transcriptase PCR for rapid detection of Mycobacterium leprae in skin specimens.
FEMS immunology and medical microbiology 2006;48(3):319-28.
2006: Nathan A Groathouse; Amol Amin; Maria Angela M Marques; John S Spencer; Robert Gelber; Dennis L Knudson; John Belisle; Patrick J Brennan; Richard Slayden
Use of protein microarrays to define the humoral immune response in leprosy patients and identification of disease-state-specific antigenic profiles.
Infection and immunity 2006;74(11):6458-66.
2006: Devinder Kaur; Stefan Berg; Premkumar Dinadayala; Brigitte Gicquel; Delphi Chatterjee; Michael R McNeil; Varalakshmi D Vissa; Dean Crick; Mary Jackson; Patrick J Brennan
Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13664-9.
2006: Katarína Mikusová; Martina Belánová; Jana Korduláková; Kristine Honda; Michael R McNeil; Sebabrata Mahapatra; Dean Crick; Patrick J Brennan
Identification of a novel galactosyl transferase involved in biosynthesis of the mycobacterial cell wall.
Journal of bacteriology 2006;188(18):6592-8.
2006: Premkumar Dinadayala; Devinder Kaur; Stefan Berg; Anita G Amin; Varalakshmi D Vissa; Delphi Chatterjee; Patrick J Brennan; Dean Crick
Genetic basis for the synthesis of the immunomodulatory mannose caps of lipoarabinomannan in Mycobacterium tuberculosis.
The Journal of biological chemistry 2006;281(29):20027-35.
2006: Romulo Aráoz; Nadine Honoré; Sayera Banu; Caroline Demangel; Yacouba Cissoko; Charles Arama; Mohammad Khaja Mafij Uddin; S K Abdul Hadi; Marc Monot; Sang-Nae Cho; Baohong Ji; Patrick J Brennan; Samba Sow; Stewart T Cole
Towards an immunodiagnostic test for leprosy.
Microbes and infection / Institut Pasteur 2006;8(8):2270-6.
2006: Patrick J Brennan; Sandra J Saouaf; Steven J Van Dyken; Jamey D Marth; Bin LI; Avinash Bhandoola; Mark I Greene
Sialylation regulates peripheral tolerance in CD4+ T cells.
International immunology 2006;18(5):627-35.
2006: Nathan A Groathouse; Susan E Brown; Dennis L Knudson; Patrick J Brennan; Richard Slayden
Isothermal amplification and molecular typing of the obligate intracellular pathogen Mycobacterium leprae isolated from tissues of unknown origins.
Journal of clinical microbiology 2006;44(4):1502-8.
2006: Romulo Aráoz; Nadine Honoré; Sungae Cho; Jong-Pill Kim; Sang-Nae Cho; Marc Monot; Caroline Demangel; Patrick J Brennan; Stewart T Cole
Antigen discovery: a postgenomic approach to leprosy diagnosis.
Infection and immunity 2006;74(1):175-82.
2005: John S Spencer; Hazel M Dockrell; Hee Jin Kim; Maria Angela M Marques; Diana L Williams; Marcia V S B Martins; Marcio L F Martins; Monica C B S Lima; Euzenir N Sarno; Geraldo Pereira; Haroldo J Matos; Leila S Fonseca; Elizabeth P Sampaio; Tom H M Ottenhoff; Annemieke Geluk; Sang-Nae Cho; neil stoker; Stewart T Cole; Patrick J Brennan; Maria Cristina Vidal Pessolani
Identification of specific proteins and peptides in Mycobacterium leprae suitable for the selective diagnosis of leprosy.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):7930-8.
2005: Katarína Mikusová; Hairong Huang; Tetsuya Yagi; Marcelle Holsters; Danny Vereecke; Wim D'Haeze; Michael S Scherman; Patrick J Brennan; Michael R McNeil; Dean Crick
Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose.
Journal of bacteriology 2005;187(23):8020-5.
2005: Annemieke Geluk; Michel Klein; Kees L M C Franken; Krista E van Meijgaarden; Brigitte Wieles; Kelly Pereira; Samira Bührer-Sékula; Paul R Klatser; Patrick J Brennan; John S Spencer; Diana L Williams; Maria Cristina Vidal Pessolani; Elizabeth P Sampaio; Tom H M Ottenhoff
Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection.
Infection and immunity 2005;73(9):5636-44.
2005: Cristiana Soares de Lima; Laurence Zulianello; Maria Angela M Marques; Heejin Kim; Michelle Iespa Portugal; Sérgio Luiz Gomes Antunes; Franco D Menozzi; Tom H M Ottenhoff; Patrick J Brennan; Maria Cristina Vidal Pessolani
Mapping the laminin-binding and adhesive domain of the cell surface-associated Hlp/LBP protein from Mycobacterium leprae.
Microbes and infection / Institut Pasteur 2005;7(9-10):1097-109.
2005: Marc Monot; Nadine Honoré; Thierry Garnier; Romulo Araoz; Jean-Yves Coppée; Céline Lacroix; Samba Sow; John S Spencer; Richard W Truman; Diana L Williams; Robert Gelber; Marcos Virmond; Béatrice Flageul; Sang-Nae Cho; Baohong Ji; Alberto Paniz-Mondolfi; Jacinto Convit; Saroj Young; Paul E Fine; Voahangy Rasolofo; Patrick J Brennan; Stewart T Cole
On the origin of leprosy.
Science (New York, N.Y.) 2005;308(5724):1040-2.
2005: Sebabrata Mahapatra; Tetsuya Yagi; John Belisle; Benjamin J Espinosa; Preston J Hill; Michael R McNeil; Patrick J Brennan; Dean Crick
Mycobacterial lipid II is composed of a complex mixture of modified muramyl and peptide moieties linked to decaprenyl phosphate.
Journal of bacteriology 2005;187(8):2747-57.
2005: Sebabrata Mahapatra; Hataichanok Scherman; Patrick J Brennan; Dean Crick
N Glycolylation of the nucleotide precursors of peptidoglycan biosynthesis of Mycobacterium spp. is altered by drug treatment.
Journal of bacteriology 2005;187(7):2341-7.
2005: Peter Allan Sieling; Jordi B Torrelles; Steffen Stenger; Woosin Chung; Anne E Burdick; Thomas H Rea; Patrick J Brennan; John Belisle; Steven A Porcelli; Robert L Modlin
The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2637-44.
2005: Stefan Berg; James Starbuck; Jordi B Torrelles; Varalakshmi D Vissa; Dean Crick; Delphi Chatterjee; Patrick J Brennan
Roles of conserved proline and glycosyltransferase motifs of EmbC in biosynthesis of lipoarabinomannan.
The Journal of biological chemistry 2005;280(7):5651-63.
2004: Devinder Kaur; Patrick J Brennan; Dean Crick
Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis.
Journal of bacteriology 2004;186(22):7564-70.
2004: Maria Angela M Marques; Benjamin J Espinosa; Erika K Xavier da Silveira; Maria Cristina Vidal Pessolani; Alex Chapeaurouge; Jonas Perales; Karen M Dobos; John Belisle; John S Spencer; Patrick J Brennan
Continued proteomic analysis of Mycobacterium leprae subcellular fractions.
Proteomics 2004;4(10):2942-53.
2004: Jordi B Torrelles; Kay-Hooi Khoo; Peter Allan Sieling; Robert L Modlin; Nannan Zhang; Angela M Marques; Achim Treumann; Christopher D Rithner; Patrick J Brennan; Delphi Chatterjee
Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis.
The Journal of biological chemistry 2004;279(39):41227-39.
2004: Nancy L Wengenack; Brian D Lane; Preston J Hill; James R Uhl; Gudrun S Lukat-Rodgers; Leslie Hall; Glenn D Roberts; Franklin R Cockerill; Patrick J Brennan; Kenton R Rodgers; John Belisle; Frank Rusnak
Purification and characterization of Mycobacterium tuberculosis KatG, KatG(S315T), and Mycobacterium bovis KatG(R463L).
Protein expression and purification 2004;36(2):232-43.
2004: John S Spencer; Hee Jin Kim; Angela M Marques; Mercedes Gonzalez-Juarerro; Monica C B S Lima; Varalakshmi D Vissa; Richard W Truman; Maria Laura Gennaro; Sang-Nae Cho; Stewart T Cole; Patrick J Brennan
Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10.
Infection and immunity 2004;72(6):3161-70.
2004: Rakesh K Dhiman; Mark C Schulbach; Sebabrata Mahapatra; Alain Baulard; Varalakshmi D Vissa; Patrick J Brennan; Dean Crick
Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis.
Journal of lipid research 2004;45(6):1140-7.
2004: Yasuko Yamashita; Yumi Maeda; Fumihiko Takeshita; Patrick J Brennan; Masahiko Makino
Role of the polypeptide region of a 33kDa mycobacterial lipoprotein for efficient IL-12 production.
Cellular immunology 2004;229(1):13-20.
2004: Nathan A Groathouse; Becky Rivoire; Hansuk Kim; Hyeyoung Lee; Sang-Nae Cho; Patrick J Brennan; Varalakshmi D Vissa
Multiple polymorphic loci for molecular typing of strains of Mycobacterium leprae.
Journal of clinical microbiology 2004;42(4):1666-72.
2004: Robert E Hunger; Peter Allan Sieling; Maria Teresa Ochoa; Makoto Sugaya; Anne E Burdick; Thomas H Rea; Patrick J Brennan; John Belisle; Andrew Blauvelt; Steven A Porcelli; Robert L Modlin
Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.
The Journal of clinical investigation 2004;113(5):701-8.
2004: Yumi Maeda; Patrick J Brennan; Masahiko Makino
Studies of lipoproteins of Mycobacterium leprae.
Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association 2004;73(1):15-21.
2004: Kelly J Henning; Patrick J Brennan; Cindy Hoegg; Eileen O'Rourke; Bernard D Dyer; Thomas L Grace
Health system preparedness for bioterrorism: bringing the tabletop to the hospital.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 2004;25(2):146-55.
2004: Geoffrey D Coxon; Juma'a R Al Dulayymi; Caroline Morehouse; Patrick J Brennan; Gurdyal S Besra; Mark S Baird; David E Minnikin
Synthesis and properties of methyl 5-(1'R,2'S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega-19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids.
Chemistry and physics of lipids 2004;127(1):35-46.
2003: Benjawan Phetsuksiri; Mary Jackson; Hataichanok Scherman; Michael McNeil; Gurdyal S Besra; Alain Baulard; Richard Slayden; Andrea DeBarber; Clifton E Barry; Mark S Baird; Dean Crick; Patrick J Brennan
Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis.
The Journal of biological chemistry 2003;278(52):53123-30.
2003: Nannan Zhang; Jordi B Torrelles; Michael R McNeil; Vincent E Escuyer; Kay-Hooi Khoo; Patrick J Brennan; Delphi Chatterjee
The Emb proteins of mycobacteria direct arabinosylation of lipoarabinomannan and arabinogalactan via an N-terminal recognition region and a C-terminal synthetic region.
Molecular microbiology 2003;50(1):69-76.
2003: Jana Korduláková; Martine GILLERON; Germain Puzo; Patrick J Brennan; Brigitte Gicquel; Katarína Mikusová; Mary Jackson
Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species.
The Journal of biological chemistry 2003;278(38):36285-95.
2003: Tetsuya Yagi; Sebabrata Mahapatra; Katarina Mikusova; Dean Crick; Patrick J Brennan
Polymerization of mycobacterial arabinogalactan and ligation to peptidoglycan.
The Journal of biological chemistry 2003;278(29):26497-504.
2003: Boosbun Chua-Intra; Sukanya Wattanapokayakit; Sopa Srisungngam; Tawee Srisungngam; Krisada Mahotarn; Patrick J Brennan; Juraj Ivanyi
T-cell recognition of peptides from the Mycobacterium leprae 35 kDa protein in Thai leprosy patients, healthy contacts, and non-contacts.
Immunology letters 2003;88(1):71-6.
2003: Stephan R Krutzik; Maria Teresa Ochoa; Peter Allan Sieling; Satoshi Uematsu; Yolanda W Ng; Annaliza J Legaspi; Philip T Liu; Stewart T Cole; Paul J Godowski; Yumi Maeda; Euzenir N Sarno; Michael V Norgard; Patrick J Brennan; Shizuo Akira; Thomas H Rea; Robert L Modlin
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.
Nature medicine 2003;9(5):525-32.
2003: Paul C McGovern; Ebbing Lautenbach; Patrick J Brennan; Robert Lustig; Neil O Fishman
Risk factors for postcraniotomy surgical site infection after 1,3-bis (2-chloroethyl)-1-nitrosourea (Gliadel) wafer placement.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2003;36(6):759-65.
2003: Sandra J Saouaf; Patrick J Brennan; Yuan Shen; Mark I Greene
Mechanisms of peripheral immune tolerance: conversion of the immune to the unresponsive phenotype.
Immunologic research 2003;28(3):193-9.
2003: Patrick J Brennan; Sandra J Saouaf; Mark I Greene; Yuan Shen
Anergy and suppression as coexistent mechanisms for the maintenance of peripheral T cell tolerance.
Immunologic research 2003;27(2-3):295-302.
2003: Patrick J Brennan
Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2003;83(1-3):91-7.
2002: Ann Marie Bailey; Sebabrata Mahapatra; Patrick J Brennan; Dean Crick
Identification, cloning, purification, and enzymatic characterization of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase.
Glycobiology 2002;12(12):813-20.
2002: Ian C Hancock; Stephen Carman; Gurdyal S Besra; Patrick J Brennan; Emma Waite
Ligation of arabinogalactan to peptidoglycan in the cell wall of Mycobacterium smegmatis requires concomitant synthesis of the two wall polymers.
Microbiology (Reading, England) 2002;148(Pt 10):3059-67.
2002: Devinder Kaur; Todd L Lowary; Varalakshmi D Vissa; Dean Crick; Patrick J Brennan
Characterization of the epitope of anti-lipoarabinomannan antibodies as the terminal hexaarabinofuranosyl motif of mycobacterial arabinans.
Microbiology (Reading, England) 2002;148(Pt 10):3049-57.
2002: Jana Korduláková; Martine GILLERON; Katarina Mikusova; Germain Puzo; Patrick J Brennan; Brigitte Gicquel; Mary Jackson
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria.
The Journal of biological chemistry 2002;277(35):31335-44.
2002: Yumi Maeda; Masahiko Makino; Dean Crick; Sebabrata Mahapatra; Sopa Srisungnam; Takemasa Takii; Yoshiko Kashiwabara; Patrick J Brennan
Novel 33-kilodalton lipoprotein from Mycobacterium leprae.
Infection and immunity 2002;70(8):4106-11.
2002: Sudagar S Gurcha; Alain Baulard; Laurent Kremer; Camille Locht; D Branch Moody; Walter Muhlecker; Catherine E Costello; Dean Crick; Patrick J Brennan; Gurdyal S Besra
Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.
The Biochemical journal 2002;365(Pt 2):441-50.
2002: Howard N Cooper; Sudagar S Gurcha; Jerome Nigou; Patrick J Brennan; John Belisle; Gurdyal S Besra; Douglas Young
Characterization of mycobacterial protein glycosyltransferase activity using synthetic peptide acceptors in a cell-free assay.
Glycobiology 2002;12(7):427-34.
2002: Laurent Kremer; Lynn Dover; Séverine Carrère; K Madhavan Nampoothiri; Sarah Lesjean; Alistair K Brown; Patrick J Brennan; David E Minnikin; Camille Locht; Gurdyal S Besra
Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.
The Biochemical journal 2002;364(Pt 2):423-30.
2002: Laurent Kremer; Sudagar S Gurcha; Pablo Bifani; Paul G Hitchen; Alain Baulard; Howard R Morris; Anne Dell; Patrick J Brennan; Gurdyal S Besra
Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.
The Biochemical journal 2002;363(Pt 3):437-47.
2002: John S Spencer; Maria Angela M Marques; Monica C B S Lima; Ana Paula Junqueira-Kipnis; Bruce C Gregory; Richard W Truman; Patrick J Brennan
Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6.
Infection and immunity 2002;70(2):1010-3.
2002: Jordi B Torrelles; D Ellis; T Osborne; A Hoefer; Ian M Orme; Delphi Chatterjee; Patrick J Brennan; Andrea M Cooper
Characterization of virulence, colony morphotype and the glycopeptidolipid of Mycobacterium avium strain 104.
Tuberculosis (Edinburgh, Scotland) 2002;82(6):293-300.
2001: Vincent E Escuyer; Marie-Annick Lety; Jordi B Torrelles; Kay-Hooi Khoo; J B Tang; Christopher D Rithner; Claude Frehel; Michael R McNeil; Patrick J Brennan; Delphi Chatterjee
The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan.
The Journal of biological chemistry 2001;276(52):48854-62.
2001: Patrick J Brennan; Varalakshmi D Vissa
Genomic evidence for the retention of the essential mycobacterial cell wall in the otherwise defective Mycobacterium leprae.
Leprosy review 2001;72(4):415-28.
2001: Vincent Lo Re; Patrick J Brennan; Jill Wadlin; Ransom Weaver; Irving Nachamkin
Infected branchial cleft cyst due to Bordetella bronchiseptica in an immunocompetent patient.
Journal of clinical microbiology 2001;39(11):4210-2.
2001: Dean Crick; Sebabrata Mahapatra; Patrick J Brennan
Biosynthesis of the arabinogalactan-peptidoglycan complex of Mycobacterium tuberculosis.
Glycobiology 2001;11(9):107R-118R.
2001: Laurent Kremer; K Madhavan Nampoothiri; Sarah Lesjean; Lynn Dover; S Graham; J Betts; Patrick J Brennan; David E Minnikin; Camille Locht; Gurdyal S Besra
Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.
The Journal of biological chemistry 2001;276(30):27967-74.
2001: Laurent Kremer; Lynn Dover; Caroline Morehouse; P Hitchin; M Everett; Howard R Morris; Anne Dell; Patrick J Brennan; M R McNeil; C Flaherty; K Duncan; Gurdyal S Besra
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase.
The Journal of biological chemistry 2001;276(28):26430-40.
2001: Mark C Schulbach; Sebabrata Mahapatra; Marco Macchia; Silvia Barontini; Chiara Papi; Filippo Minutolo; Simone Bertini; Patrick J Brennan; Dean Crick
Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.
The Journal of biological chemistry 2001;276(15):11624-30.
2001: J R Brown; R A Field; A Barker; M Guy; R Grewal; Kay-Hooi Khoo; Patrick J Brennan; Gurdyal S Besra; D Chatterjec
Synthetic mannosides act as acceptors for mycobacterial alpha1-6 mannosyltransferase.
Bioorganic & medicinal chemistry 2001;9(4):815-24.
2001: Maria Angela M Marques; S Mahapatra; Euzenir N Sarno; S Santos; John S Spencer; Patrick J Brennan; Maria Cristina Vidal Pessolani
Further biochemical characterization of Mycobacterium leprae laminin-binding proteins.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2001;34(4):463-70.
2001: Rohit K Katial; Joyce N Hershey; T Purohit-Seth; John Belisle; Patrick J Brennan; John S Spencer; Renata J M Engler
Cell-mediated immune response to tuberculosis antigens: comparison of skin testing and measurement of in vitro gamma interferon production in whole-blood culture.
Clinical and diagnostic laboratory immunology 2001;8(2):339-45.
2001: Varalakshmi D Vissa; Patrick J Brennan
The genome of Mycobacterium leprae: a minimal mycobacterial gene set.
Genome biology 2001;2(8):REVIEWS1023.
2001: Maria Angela M Marques; V L Ant nio; Euzenir N Sarno; Patrick J Brennan; Maria Cristina Vidal Pessolani
Binding of alpha2-laminins by pathogenic and non-pathogenic mycobacteria and adherence to Schwann cells.
Journal of medical microbiology 2001;50(1):23-8.
2000: Patrick J Brennan
Skin test development in leprosy: progress with first-generation skin test antigens, and an approach to the second generation.
Leprosy review 2000;71 Suppl():S50-4.
2000: Sebabrata Mahapatra; Dean Crick; Patrick J Brennan
Comparison of the UDP-N-acetylmuramate:L-alanine ligase enzymes from Mycobacterium tuberculosis and Mycobacterium leprae.
Journal of bacteriology 2000;182(23):6827-30.
2000: Katarína Mikusová; Tetsuya Yagi; R Stern; Michael R McNeil; Gurdyal S Besra; Dean Crick; Patrick J Brennan
Biosynthesis of the galactan component of the mycobacterial cell wall.
The Journal of biological chemistry 2000;275(43):33890-7.
2000: M A de Melo Marques; S Mahapatra; D Nandan; T Dick; Euzenir N Sarno; Patrick J Brennan; Maria Cristina Vidal Pessolani
Bacterial and host-derived cationic proteins bind alpha2-laminins and enhance Mycobacterium leprae attachment to human Schwann cells.
Microbes and infection / Institut Pasteur 2000;2(12):1407-17.
2000: Dean Crick; Mark C Schulbach; E E Zink; Marco Macchia; Silvia Barontini; Gurdyal S Besra; Patrick J Brennan
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.
Journal of bacteriology 2000;182(20):5771-8.
2000: Mary Jackson; Dean Crick; Patrick J Brennan
Phosphatidylinositol is an essential phospholipid of mycobacteria.
The Journal of biological chemistry 2000;275(39):30092-9.
2000: Alain Baulard; J C Betts; Jean Engohang-Ndong; S Quan; Ruth A McAdam; Patrick J Brennan; Camille Locht; Gurdyal S Besra
Activation of the pro-drug ethionamide is regulated in mycobacteria.
The Journal of biological chemistry 2000;275(36):28326-31.
2000: Mark C Schulbach; Patrick J Brennan; Dean Crick
Identification of a short (C15) chain Z-isoprenyl diphosphate synthase and a homologous long (C50) chain isoprenyl diphosphate synthase in Mycobacterium tuberculosis.
The Journal of biological chemistry 2000;275(30):22876-81.
2000: Laurent Kremer; James D Douglas; Alain Baulard; Caroline Morehouse; M R Guy; DAvid Alland; Lynn Dover; Jeremy H Lakey; William R. Jacobs Jr.; Patrick J Brennan; David E Minnikin; Gurdyal S Besra
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.
The Journal of biological chemistry 2000;275(22):16857-64.
1999: Merrill L Schaeffer; Kay-Hooi Khoo; Gurdyal S Besra; Delphi Chatterjee; Patrick J Brennan; John Belisle; Julia M Inamine
The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis.
The Journal of biological chemistry 1999;274(44):31625-31.
1999: Patrick J Brennan
The US-Japan Joint Leprosy Research Program meeting, San Francisco, June 28-30, 1999.
Leprosy review 1999;70(3):250-3.
1999: Hans D Brightbill; D H Libraty; Stephan R Krutzik; RB Yang; John Belisle; Joshua R Bleharski; M Maitland; Michael V Norgard; Scott Plevy; S T Smale; Patrick J Brennan; Barry R Bloom; Paul J Godowski; Robert L Modlin
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
Science (New York, N.Y.) 1999;285(5428):732-6.
1999: Ebbing Lautenbach; Warren B Bilker; Patrick J Brennan
Enterococcal bacteremia: risk factors for vancomycin resistance and predictors of mortality.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 1999;20(5):318-23.
1999: Benjawan Phetsuksiri; Alain Baulard; A M Cooper; David E Minnikin; James D Douglas; Gurdyal S Besra; Patrick J Brennan
Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis.
Antimicrobial agents and chemotherapy 1999;43(5):1042-51.
1998: Ebbing Lautenbach; Mindy G Schuster; Warren B Bilker; Patrick J Brennan
The role of chloramphenicol in the treatment of bloodstream infection due to vancomycin-resistant Enterococcus.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998;27(5):1259-65.
1998: Torsten M Eckstein; F S Silbaq; Delphi Chatterjee; N J Kelly; Patrick J Brennan; John Belisle
Identification and recombinant expression of a Mycobacterium avium rhamnosyltransferase gene (rtfA) involved in glycopeptidolipid biosynthesis.
Journal of bacteriology 1998;180(21):5567-73.
1998: F S Silbaq; Sang-Nae Cho; Stewart T Cole; Patrick J Brennan
Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis.
Infection and immunity 1998;66(11):5576-9.
1998: Maria Angela M Marques; S Chitale; Patrick J Brennan; Maria Cristina Vidal Pessolani
Mapping and identification of the major cell wall-associated components of Mycobacterium leprae.
Infection and immunity 1998;66(6):2625-31.
1998: Richard E Lee; Patrick J Brennan; Gurdyal S Besra
Synthesis of beta-D-arabinofuranosyl-1-monophosphoryl polyprenols: examination of their function as mycobacterial arabinosyl transferase donors.
Bioorganic & medicinal chemistry letters 1998;8(8):951-4.
1997: Richard E Lee; Patrick J Brennan; Gurdyal S Besra
Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assay.
Glycobiology 1997;7(8):1121-8.
1997: A S Morgan; Patrick J Brennan; Neil O Fishman
Impact of a vancomycin restriction policy on use and cost of vancomycin and incidence of vancomycin-resistant Enterococcus.
The Annals of pharmacotherapy 1997;31(9):970-3.
1997: Gurdyal S Besra; Patrick J Brennan
The mycobacterial cell wall: biosynthesis of arabinogalactan and lipoarabinomannan.
Biochemical Society transactions 1997;25(3):845-50.
1997: Patrick J Brennan
Tuberculosis in the context of emerging and reemerging diseases.
FEMS immunology and medical microbiology 1997;18(4):263-9.
1997: Gurdyal S Besra; C B Morehouse; C M Rittner; C J Waechter; Patrick J Brennan
Biosynthesis of mycobacterial lipoarabinomannan.
The Journal of biological chemistry 1997;272(29):18460-6.
1997: Richard E Lee; J W Armour; K Takayama; Patrick J Brennan; Gurdyal S Besra
Mycolic acid biosynthesis: definition and targeting of the Claisen condensation step.
Biochimica et biophysica acta 1997;1346(3):275-84.
1997: Yi Xin; Richard E Lee; Michael S Scherman; Kay-Hooi Khoo; Gurdyal S Besra; Patrick J Brennan; Michael McNeil
Characterization of the in vitro synthesized arabinan of mycobacterial cell walls.
Biochimica et biophysica acta 1997;1335(3):231-4.
1997: John Belisle; Varalakshmi D Vissa; T Sievert; K Takayama; Patrick J Brennan; Gurdyal S Besra
Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis.
Science (New York, N.Y.) 1997;276(5317):1420-2.
1997: Patrick J Brennan; Gurdyal S Besra
Structure, function and biogenesis of the mycobacterial cell wall.
Biochemical Society transactions 1997;25(1):188-94.
1996: Richard Slayden; Richard E Lee; J W Armour; A M Cooper; Ian M Orme; Patrick J Brennan; Gurdyal S Besra
Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis.
Antimicrobial agents and chemotherapy 1996;40(12):2813-9.
1996: Patrick J Brennan; Sang-Nae Cho; Paul R Klatser
Bangkok Workshop on Leprosy Research. Immunodiagnostics, including skin tests.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1996;64(4 Suppl):S58-62.
1996: M C Pessolani; Patrick J Brennan
Molecular definition and identification of new proteins of Mycobacterium leprae.
Infection and immunity 1996;64(12):5425-7.
1996: Kay-Hooi Khoo; E Douglas; P Azadi; J M Inamine; Gurdyal S Besra; K Mikusová; Patrick J Brennan; Delphi Chatterjee
Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutol.
The Journal of biological chemistry 1996;271(45):28682-90.
1996: AE Belanger; Gurdyal S Besra; Michael E Ford; K Mikusová; John Belisle; Patrick J Brennan; J M Inamine
The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11919-24.
1996: Hazel M Dockrell; S K Young; K Britton; Patrick J Brennan; B Rivoire; M F Waters; Sebastian Lucas; Firdaus Shahid; M Dojki; T J Chiang; Q Ehsan; Keith P W J McAdam; Rabia Hussain
Induction of Th1 cytokine responses by mycobacterial antigens in leprosy.
Infection and immunity 1996;64(10):4385-9.
1996: Kay-Hooi Khoo; R Suzuki; Anne Dell; H R Morris; Michael R McNeil; Patrick J Brennan; Gurdyal S Besra
Chemistry of the lyxose-containing mycobacteriophage receptors of Mycobacterium phlei/Mycobacterium smegmatis.
Biochemistry 1996;35(36):11812-9.
1996: Kay-Hooi Khoo; Delphi Chatterjee; Anne Dell; H R Morris; Patrick J Brennan; P Draper
Novel O-methylated terminal glucuronic acid characterizes the polar glycopeptidolipids of Mycobacterium habana strain TMC 5135.
The Journal of biological chemistry 1996;271(21):12333-42.
1996: K M Dobos; Kay-Hooi Khoo; K M Swiderek; Patrick J Brennan; John Belisle
Definition of the full extent of glycosylation of the 45-kilodalton glycoprotein of Mycobacterium tuberculosis.
Journal of bacteriology 1996;178(9):2498-506.
1996: K Mikusová; M Mikus; Gurdyal S Besra; I Hancock; Patrick J Brennan
Biosynthesis of the linkage region of the mycobacterial cell wall.
The Journal of biological chemistry 1996;271(13):7820-8.
1996: R E Lee; Patrick J Brennan; Gurdyal S Besra
Mycobacterium tuberculosis cell envelope.
Current topics in microbiology and immunology 1996;215():1-27.
1995: K Mikusová; Richard Slayden; Gurdyal S Besra; Patrick J Brennan
Biogenesis of the mycobacterial cell wall and the site of action of ethambutol.
Antimicrobial agents and chemotherapy 1995;39(11):2484-9.
1995: Patrick J Brennan; E Abrutyn
Developing policies and guidelines.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 1995;16(9):512-7.
1995: K M Dobos; K Swiderek; Kay-Hooi Khoo; Patrick J Brennan; John Belisle
Evidence for glycosylation sites on the 45-kilodalton glycoprotein of Mycobacterium tuberculosis.
Infection and immunity 1995;63(8):2846-53.
1995: Alan D. Roberts; MG Sonnenberg; D J Ordway; S K Furney; Patrick J Brennan; John Belisle; Ian M Orme
Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis.
Immunology 1995;85(3):502-8.
1995: Nathalie Winter; James A Triccas; B Rivoire; M C Pessolani; K Eiglmeier; E M Lim; S W Hunter; Patrick J Brennan; Warwick J Britton
Characterization of the gene encoding the immunodominant 35 kDa protein of Mycobacterium leprae.
Molecular microbiology 1995;16(5):865-76.
1995: Kay-Hooi Khoo; Anne Dell; H R Morris; Patrick J Brennan; Delphi Chatterjee
Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium.
The Journal of biological chemistry 1995;270(21):12380-9.
1995: A H Norris; J P Reilly; Paul H Edelstein; Patrick J Brennan; Mindy G Schuster
Chloramphenicol for the treatment of vancomycin-resistant enterococcal infections.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1995;20(5):1137-44.
1995: Gurdyal S Besra; Kay-Hooi Khoo; Michael R McNeil; Anne Dell; H R Morris; Patrick J Brennan
A new interpretation of the structure of the mycolyl-arabinogalactan complex of Mycobacterium tuberculosis as revealed through characterization of oligoglycosylalditol fragments by fast-atom bombardment mass spectrometry and 1H nuclear magnetic resonance spectroscopy.
Biochemistry 1995;34(13):4257-66.
1995: L Deng; K Mikusová; K G Robuck; Michael S Scherman; Patrick J Brennan; Michael R McNeil
Recognition of multiple effects of ethambutol on metabolism of mycobacterial cell envelope.
Antimicrobial agents and chemotherapy 1995;39(3):694-701.
1995: V Sastry; Patrick J Brennan; M M Levy; N Fishman; A L Friedman; Ali Naji; Clyde F Barker; Kenneth L Brayman
Vancomycin-resistant enterococci: an emerging pathogen in immunosuppressed transplant recipients.
Transplantation proceedings 1995;27(1):954-5.
1995: D J Shulkin; Patrick J Brennan
The cost of caring for patients with tuberculosis: planning for a disease on the rise.
American journal of infection control 1995;23(1):1-4.
1995: Patrick J Brennan; H Nikaido
The envelope of mycobacteria.
Annual review of biochemistry 1995;64():29-63.
1995: GO Aspinall; Delphi Chatterjee; Patrick J Brennan
The variable surface glycolipids of mycobacteria: structures, synthesis of epitopes, and biological properties.
Advances in carbohydrate chemistry and biochemistry 1995;51():169-242.
1994: Gurdyal S Besra; T Sievert; Richard E Lee; Richard Slayden; Patrick J Brennan; K Takayama
Identification of the apparent carrier in mycolic acid synthesis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12735-9.
1994: Gurdyal S Besra; S S Gurcha; Kay-Hooi Khoo; H R Morris; Anne Dell; M E Hamid; David E Minnikin; M Goodfellow; Patrick J Brennan
Characterization of the specific antigenicity of representatives of M. senegalense and related bacteria.
Zentralblatt für Bakteriologie : international journal of medical microbiology 1994;281(4):415-32.
1994: J A Mills; Michael R McNeil; John Belisle; William R. Jacobs Jr.; Patrick J Brennan
Loci of Mycobacterium avium ser2 gene cluster and their functions.
Journal of bacteriology 1994;176(16):4803-8.
1994: M C Pessolani; D R Smith; B Rivoire; J McCormick; S A Hefta; S T Cole; Patrick J Brennan
Purification, characterization, gene sequence, and significance of a bacterioferritin from Mycobacterium leprae.
The Journal of experimental medicine 1994;180(1):319-27.
1994: B Rivoire; M C Pessolani; C M Bozic; S W Hunter; S A Hefta; V Mehra; Patrick J Brennan
Chemical definition, cloning, and expression of the major protein of the leprosy bacillus.
Infection and immunity 1994;62(6):2417-25.
1994: Ian M Orme; S K Furney; P S Skinner; AD Roberts; Patrick J Brennan; D G Russell; Hiroe Clerk Shiratsuchi; Jerrold Jay Ellner; W Y Weiser
Inhibition of growth Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor.
Infection and immunity 1994;62(5):2141.
1994: S Prinzis; B Rivoire; Patrick J Brennan
Search for the molecular basis of morphological variation in Mycobacterium avium.
Infection and immunity 1994;62(5):1946-51.
1994: Michael R McNeil; K G Robuck; M Harter; Patrick J Brennan
Enzymatic evidence for the presence of a critical terminal hexa-arabinoside in the cell walls of Mycobacterium tuberculosis.
Glycobiology 1994;4(2):165-73.
1994: John Belisle; Patrick J Brennan
Molecular basis of colony morphology in Mycobacterium avium.
Research in microbiology 1994;145(3):237-42.
1994: Gurdyal S Besra; Kay-Hooi Khoo; John Belisle; Michael R McNeil; H R Morris; Anne Dell; Patrick J Brennan
New pyruvylated, glycosylated acyltrehaloses from Mycobacterium smegmatis strains, and their implications for phage resistance in mycobacteria.
Carbohydrate research 1994;251():99-114.
1994: Patrick J Brennan; Delphi Chatterjee; T Fujiwara; Sang-Nae Cho
Leprosy-specific neoglycoconjugates: synthesis and application to serodiagnosis of leprosy.
Methods in enzymology 1994;242():27-37.
1993: E Seltzer; Kevin Schulman; Patrick J Brennan; L A Lynn
Patient attitudes toward rooming with persons with HIV infection.
The Journal of family practice 1993;37(6):564-8.
1993: Gurdyal S Besra; Michael R McNeil; Kay-Hooi Khoo; Anne Dell; H R Morris; Patrick J Brennan
Trehalose-containing lipooligosaccharides of Mycobacterium gordonae: presence of a mono-O-methyltetra-O-acyltrehalose "core" and branching in the oligosaccharide backbone.
Biochemistry 1993;32(47):12705-14.
1993: M Daffe; Michael McNeil; Patrick J Brennan
Major structural features of the cell wall arabinogalactans of Mycobacterium, Rhodococcus, and Nocardia spp.
Carbohydrate research 1993;249(2):383-98.
1993: S Prinzis; Delphi Chatterjee; Patrick J Brennan
Structure and antigenicity of lipoarabinomannan from Mycobacterium bovis BCG.
Journal of general microbiology 1993;139(11):2649-58.
1993: Delphi Chatterjee; Kay-Hooi Khoo; Michael R McNeil; Anne Dell; H R Morris; Patrick J Brennan
Structural definition of the non-reducing termini of mannose-capped LAM from Mycobacterium tuberculosis through selective enzymatic degradation and fast atom bombardment-mass spectrometry.
Glycobiology 1993;3(5):497-506.
1993: Mindy G Schuster; Patrick J Brennan; Paul H Edelstein
Persistent bacteremia with Erysipelothrix rhusiopathiae in a hospitalized patient.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1993;17(4):783-4.
1993: M C Pessolani; S W Hunter; Patrick J Brennan
Relationship between host histones and armadillo-derived Mycobacterium leprae.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1993;61(3):381-8.
1993: John Belisle; K Klaczkiewicz; Patrick J Brennan; William R. Jacobs Jr.; J M Inamine
Rough morphological variants of Mycobacterium avium. Characterization of genomic deletions resulting in the loss of glycopeptidolipid expression.
The Journal of biological chemistry 1993;268(14):10517-23.
1993: John Belisle; Michael R McNeil; Delphi Chatterjee; J M Inamine; Patrick J Brennan
Expression of the core lipopeptide of the glycopeptidolipid surface antigens in rough mutants of Mycobacterium avium.
The Journal of biological chemistry 1993;268(14):10510-6.
1993: Gurdyal S Besra; Michael R McNeil; B Rivoire; Kay-Hooi Khoo; H R Morris; Anne Dell; Patrick J Brennan
Further structural definition of a new family of glycopeptidolipids from Mycobacterium xenopi.
Biochemistry 1993;32(1):347-55.
1993: Ian M Orme; S K Furney; P S Skinner; AD Roberts; Patrick J Brennan; D G Russell; Hiroe Clerk Shiratsuchi; Jerrold Jay Ellner; W Y Weiser
Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor.
Infection and immunity 1993;61(1):338-42.
1992: GO Aspinall; D W Gammon; R K Sood; Delphi Chatterjee; B Rivoire; Patrick J Brennan
Structures of the glycopeptidolipid antigens of serovars 25 and 26 of the Mycobacterium avium serocomplex, synthesis of allyl glycosides of the outer disaccharide units and serology of the derived neoglycoproteins.
Carbohydrate research 1992;237():57-77.
1992: M C Pessolani; Patrick J Brennan
Mycobacterium leprae produces extracellular homologs of the antigen 85 complex.
Infection and immunity 1992;60(11):4452-9.
1992: Gurdyal S Besra; R C Bolton; Michael R McNeil; Malin Ridell; K E Simpson; J Glushka; H van Halbeek; Patrick J Brennan; David E Minnikin
Structural elucidation of a novel family of acyltrehaloses from Mycobacterium tuberculosis.
Biochemistry 1992;31(40):9832-7.
1992: Saroj Khanolkar-Young; Arend H J Kolk; Ase B Andersen; J Bennedsen; Patrick J Brennan; B Rivoire; Sjoukje Kuijper; Keith P W J McAdam; C Abe; H V Batra
Results of the third immunology of leprosy/immunology of tuberculosis antimycobacterial monoclonal antibody workshop.
Infection and immunity 1992;60(9):3925-7.
1992: Gurdyal S Besra; Michael R McNeil; Patrick J Brennan
Characterization of the specific antigenicity of Mycobacterium fortuitum.
Biochemistry 1992;31(28):6504-9.
1992: Peter F Barnes; D Chatterjee; J S Abrams; S Lu; E Wang; M Yamamura; Patrick J Brennan; Robert L Modlin
Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(2):541-7.
1992: B Y Lee; S A Hefta; Patrick J Brennan
Characterization of the major membrane protein of virulent Mycobacterium tuberculosis.
Infection and immunity 1992;60(5):2066-74.
1992: Peter F Barnes; D Chatterjee; Patrick J Brennan; Thomas H Rea; Robert L Modlin
Tumor necrosis factor production in patients with leprosy.
Infection and immunity 1992;60(4):1441-6.
1992: Delphi Chatterjee; karen lowell; B Rivoire; Michael R McNeil; Patrick J Brennan
Lipoarabinomannan of Mycobacterium tuberculosis. Capping with mannosyl residues in some strains.
The Journal of biological chemistry 1992;267(9):6234-9.
1992: Delphi Chatterjee; S W Hunter; Michael McNeil; Patrick J Brennan
Lipoarabinomannan. Multiglycosylated form of the mycobacterial mannosylphosphatidylinositols.
The Journal of biological chemistry 1992;267(9):6228-33.
1992: Peter F Barnes; V Mehra; B Rivoire; S J Fong; Patrick J Brennan; M S Voegtline; P Minden; R A Houghten; Barry R Bloom; Robert L Modlin
Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1835-40.
1992: Delphi Chatterjee; Alan D. Roberts; karen lowell; Patrick J Brennan; Ian M Orme
Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor.
Infection and immunity 1992;60(3):1249-53.
1992: A Y Tsang; J C Denner; Patrick J Brennan; J K McClatchy
Clinical and epidemiological importance of typing of Mycobacterium avium complex isolates.
Journal of clinical microbiology 1992;30(2):479-84.
1992: J C Denner; A Y Tsang; Delphi Chatterjee; Patrick J Brennan
Comprehensive approach to identification of serovars of Mycobacterium avium complex.
Journal of clinical microbiology 1992;30(2):473-8.
1992: V Mehra; Barry R Bloom; A C Bajardi; C L Grisso; Peter Allan Sieling; DAvid Alland; Jacinto Convit; X D Fan; S W Hunter; Patrick J Brennan
A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein.
The Journal of experimental medicine 1992;175(1):275-84.
1992: Ian M Orme; E S Miller; Alan D. Roberts; S K Furney; J P Griffin; K M Dobos; D Chi; B Rivoire; Patrick J Brennan
T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(1):189-96.
1991: John Belisle; L Pascopella; J M Inamine; Patrick J Brennan; William R. Jacobs Jr.
Isolation and expression of a gene cluster responsible for biosynthesis of the glycopeptidolipid antigens of Mycobacterium avium.
Journal of bacteriology 1991;173(21):6991-7.
1991: GO Aspinall; N K Khare; R K Sood; Delphi Chatterjee; B Rivoire; Patrick J Brennan
Structure of the glycopeptidolipid antigen of serovar 20 of the Mycobacterium avium serocomplex, synthesis of allyl glycosides of the outer di- and tri-saccharide units of the antigens of serovars 14 and 20, and serology of the derived neoglycoproteins.
Carbohydrate research 1991;216():357-73.
1991: GO Aspinall; A M Crane; D W Gammon; I H Ibrahim; N K Khare; Delphi Chatterjee; B Rivoire; Patrick J Brennan
Synthesis of allyl glycosides for conversion into neoglycoproteins bearing epitopes of mycobacterial glycolipid antigens.
Carbohydrate research 1991;216():337-55.
1991: Gurdyal S Besra; Michael McNeil; David E Minnikin; F Portaels; Malin Ridell; Patrick J Brennan
Structural elucidation and antigenicity of a novel phenolic glycolipid antigen from Mycobacterium haemophilum.
Biochemistry 1991;30(31):7772-7.
1991: Michael McNeil; M Daffe; Patrick J Brennan
Location of the mycolyl ester substituents in the cell walls of mycobacteria.
The Journal of biological chemistry 1991;266(20):13217-23.
1991: Delphi Chatterjee; C M Bozic; Michael McNeil; Patrick J Brennan
Structural features of the arabinan component of the lipoarabinomannan of Mycobacterium tuberculosis.
The Journal of biological chemistry 1991;266(15):9652-60.
1991: B Y Lee; Delphi Chatterjee; C M Bozic; Patrick J Brennan; D L Cohn; J D Bales; S M Harrison; L A Andron; Ian M Orme
Prevalence of serum antibody to the type-specific glycopeptidolipid antigens of Mycobacterium avium in human immunodeficiency virus-positive and -negative individuals.
Journal of clinical microbiology 1991;29(5):1026-9.
1991: Michael R McNeil; Patrick J Brennan
Structure, function and biogenesis of the cell envelope of mycobacteria in relation to bacterial physiology, pathogenesis and drug resistance; some thoughts and possibilities arising from recent structural information.
Research in microbiology 1991;142(4):451-63.
1991: John Chan; X D Fan; S W Hunter; Patrick J Brennan; Barry R Bloom
Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages.
Infection and immunity 1991;59(5):1755-61.
1991: M Daffe; Michael McNeil; Patrick J Brennan
Novel type-specific lipooligosaccharides from Mycobacterium tuberculosis.
Biochemistry 1991;30(2):378-88.
1991: M Daffe; Sang-Nae Cho; Delphi Chatterjee; Patrick J Brennan
Chemical synthesis and seroreactivity of a neoantigen containing the oligosaccharide hapten of the Mycobacterium tuberculosis-specific phenolic glycolipid.
The Journal of infectious diseases 1991;163(1):161-8.
1990: Michael McNeil; M Daffe; Patrick J Brennan
Evidence for the nature of the link between the arabinogalactan and peptidoglycan of mycobacterial cell walls.
The Journal of biological chemistry 1990;265(30):18200-6.
1990: S W Hunter; B Rivoire; V Mehra; Barry R Bloom; Patrick J Brennan
The major native proteins of the leprosy bacillus.
The Journal of biological chemistry 1990;265(24):14065-8.
1990: Peter F Barnes; S J Fong; Patrick J Brennan; P E Twomey; A Mazumder; Robert L Modlin
Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):149-54.
1990: S W Hunter; Patrick J Brennan
Evidence for the presence of a phosphatidylinositol anchor on the lipoarabinomannan and lipomannan of Mycobacterium tuberculosis.
The Journal of biological chemistry 1990;265(16):9272-9.
1990: M Daffe; Patrick J Brennan; Michael McNeil
Predominant structural features of the cell wall arabinogalactan of Mycobacterium tuberculosis as revealed through characterization of oligoglycosyl alditol fragments by gas chromatography/mass spectrometry and by 1H and 13C NMR analyses.
The Journal of biological chemistry 1990;265(12):6734-43.
1990: G R Hirschfield; Michael McNeil; Patrick J Brennan
Peptidoglycan-associated polypeptides of Mycobacterium tuberculosis.
Journal of bacteriology 1990;172(2):1005-13.
1989: Peter F Barnes; V Mehra; G R Hirschfield; S J Fong; C Abou-Zeid; Graham Rook; S W Hunter; Patrick J Brennan; Robert L Modlin
Characterization of T cell antigens associated with the cell wall protein-peptidoglycan complex of Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(8):2656-62.
1989: B Rivoire; B J Ranchoff; Delphi Chatterjee; H Gaylord; A Y Tsang; Arend H J Kolk; GO Aspinall; Patrick J Brennan
Generation of monoclonal antibodies to the specific sugar epitopes of Mycobacterium avium complex serovars.
Infection and immunity 1989;57(10):3147-58.
1989: John Belisle; Patrick J Brennan
Chemical basis of rough and smooth variation in mycobacteria.
Journal of bacteriology 1989;171(6):3465-70.
1989: S W Hunter; Michael McNeil; Robert L Modlin; V Mehra; Barry R Bloom; Patrick J Brennan
Isolation and characterization of the highly immunogenic cell wall-associated protein of Mycobacterium leprae.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(8):2864-72.
1989: I Jardine; G Scanlan; Michael McNeil; Patrick J Brennan
Plasma desorption mass spectrometric analysis of mycobacterial glycolipids.
Analytical chemistry 1989;61(5):416-22.
1989: Patrick J Brennan
Structure of mycobacteria: recent developments in defining cell wall carbohydrates and proteins.
Reviews of infectious diseases 1989;11 Suppl 2():S420-30.
1989: Delphi Chatterjee; C M Bozic; C Knisley; Sang-Nae Cho; Patrick J Brennan
Phenolic glycolipids of Mycobacterium bovis: new structures and synthesis of a corresponding seroreactive neoglycoprotein.
Infection and immunity 1989;57(2):322-30.
1989: Delphi Chatterjee; S W Hunter; Michael McNeil; I Jardine; Patrick J Brennan
Structure and function of mycobacterial glycolipids and glycopeptidolipids.
Acta leprologica 1989;7 Suppl 1():81-4.
1988: Delphi Chatterjee; Sang-Nae Cho; C Stewart; J T Douglas; T Fujiwara; Patrick J Brennan
Synthesis and immunoreactivity of neoglycoproteins containing the trisaccharide unit of phenolic glycolipid I of Mycobacterium leprae.
Carbohydrate research 1988;183(2):241-60.
1988: C M Bozic; Michael McNeil; Delphi Chatterjee; I Jardine; Patrick J Brennan
Further novel amido sugars within the glycopeptidolipid antigens of Mycobacterium avium.
The Journal of biological chemistry 1988;263(29):14984-91.
1988: R T Camphausen; R L Jones; Patrick J Brennan
Antigenic relationship between Mycobacterium paratuberculosis and Mycobacterium avium.
American journal of veterinary research 1988;49(8):1307-10.
1988: Michael McNeil; H Gaylord; Patrick J Brennan
N-formylkansosaminyl-(1----3)-2-O-methyl-D-rhamnopyranose: the type-specific determinant of serovariant 14 of the Mycobacterium avium complex.
Carbohydrate research 1988;177():185-98.
1988: Delphi Chatterjee; C Bozic; GO Aspinall; Patrick J Brennan
Glucuronic acid- and branched sugar-containing glycolipid antigens of Mycobacterium avium.
The Journal of biological chemistry 1988;263(9):4092-7.
1988: S W Hunter; V L Barr; Michael McNeil; I Jardine; Patrick J Brennan
Trehalose-containing lipooligosaccharide antigens of Mycobacterium sp.: presence of a mono-O-methyltri-O-acyltrehalose "core".
Biochemistry 1988;27(5):1549-56.
1988: Barry R Bloom; V Mehra; J Melancon-Kaplan; M Castes; Jacinto Convit; Patrick J Brennan; Thomas H Rea; Robert L Modlin
Mechanisms of immunological unresponsiveness in the spectra of leprosy and leishmaniasis.
Advances in experimental medicine and biology 1988;239():263-78.
1987: R T Camphausen; Michael McNeil; I Jardine; Patrick J Brennan
Location of acyl groups of trehalose-containing lipooligosaccharides of mycobacteria.
Journal of bacteriology 1987;169(12):5473-80.
1987: H Gaylord; Patrick J Brennan; D B Young; Thomas Mark Buchanan
Most Mycobacterium leprae carbohydrate-reactive monoclonal antibodies are directed to lipoarabinomannan.
Infection and immunity 1987;55(11):2860-3.
1987: Michael McNeil; S J Wallner; S W Hunter; Patrick J Brennan
Demonstration that the galactosyl and arabinosyl residues in the cell-wall arabinogalactan of Mycobacterium leprae and Mycobacterium tuberculosis are furanoid.
Carbohydrate research 1987;166(2):299-308.
1987: Michael McNeil; A Y Tsang; J K McClatchy; C Stewart; I Jardine; Patrick J Brennan
Definition of the surface antigens of Mycobacterium malmoense and use in studying the etiology of a form of mycobacteriosis.
Journal of bacteriology 1987;169(7):3312-20.
1987: H Gaylord; Patrick J Brennan
Leprosy and the leprosy bacillus: recent developments in characterization of antigens and immunology of the disease.
Annual review of microbiology 1987;41():645-75.
1986: I Jardine; S W Hunter; Patrick J Brennan; Catherine J McNeal; R D Macfarlane
Heterogeneity of bacterial antigenic lipooligosaccharides determined by californium-252 plasma desorption mass spectrometry.
Biomedical & environmental mass spectrometry 1986;13(6):273-6.
1985: C V Knisley; J J Damato; J K McClatchy; Patrick J Brennan
Rapid and sensitive identification of Mycobacterium tuberculosis.
Journal of clinical microbiology 1985;22(5):761-7.
1985: S W Hunter; I Jardine; D L Yanagihara; Patrick J Brennan
Trehalose-containing lipooligosaccharides from mycobacteria: structures of the oligosaccharide segments and recognition of a unique N-acylkanosamine-containing epitope.
Biochemistry 1985;24(11):2798-805.
1985: D L Yanagihara; V L Barr; C V Knisley; A Y Tsang; J K McClatchy; Patrick J Brennan
Enzyme-linked immunosorbent assay of glycolipid antigens for identification of mycobacteria.
Journal of clinical microbiology 1985;21(4):569-74.
1984: V Mehra; Patrick J Brennan; Elsa Rada; Jacinto Convit; Barry R Bloom
Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid.
Nature 1984;308(5955):194-6.