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Richard Brennan

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Nicola Horstmann; Jillian Orans; Samuel A Shelburne; Poul Valentin-Hansen; Richard G Brennan
Structural mechanism of Staphylococcus aureus Hfq binding to an RNA A-tract.
Nicola Horstmann; Muthiah Kumaraswami; James M Musser; Randall J Olsen; Pranoti Sahasrabhojane; Richard G Brennan; Anthony Flores; Bryce Suber; Samuel A Shelburne
Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis.
Samuel A Shelburne; Randall J Olsen; Pranoti Sahasrobhajane; Bryce Suber; Richard G Brennan; Michael T Davenport; Nicola Horstmann; David B Keith; Muthiah Kumaraswami; James M Musser
Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein.

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All Publications

2012: Nicola Horstmann; Jillian Orans; Samuel A Shelburne; Poul Valentin-Hansen; Richard G Brennan
Structural mechanism of Staphylococcus aureus Hfq binding to an RNA A-tract.
Nucleic acids research 2012;40(21):11023-35.
2011: Nicola Horstmann; Muthiah Kumaraswami; James M Musser; Randall J Olsen; Pranoti Sahasrabhojane; Richard G Brennan; Anthony Flores; Bryce Suber; Samuel A Shelburne
Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis.
PLoS pathogens 2011;7(10):e1002311.
2011: Samuel A Shelburne; Randall J Olsen; Pranoti Sahasrobhajane; Bryce Suber; Richard G Brennan; Michael T Davenport; Nicola Horstmann; David B Keith; Muthiah Kumaraswami; James M Musser
Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein.
Molecular microbiology 2011;81(2):500-14.
2011: Maria A Schumacher; Mareen Sprehe; Maike Bartholomae; Wolfgang Hillen; Richard G Brennan
Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators.
Nucleic acids research 2011;39(7):2931-42.
2011: Kate M Peters; Benjamin E Brooks; Maria A Schumacher; Ronald A Skurray; Richard G Brennan; Melissa H Brown
A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity.
PloS one 2011;6(1):e15974.
2010: Kyucheol Cho; Travis G Vaught; Hong Ji; Dongmin Gu; Catherine Papasakelariou-Yared; Nicola Horstmann; Jean Marie Jennings; Moonsup Lee; Lisa M Sevilla; Malgorzata Kloc; Albert B Reynolds; Fiona M Watt; Richard G Brennan; Andrew P Kowalczyk; Pierre D McCrea
Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.
Journal of cell science 2010;123(Pt 23):4128-44.
2010: Anders Steno Olsen; Jakob Møller-Jensen; Richard G Brennan; Poul Valentin-Hansen
C-terminally truncated derivatives of Escherichia coli Hfq are proficient in riboregulation.
Journal of molecular biology 2010;404(2):173-82.
2010: Muthiah Kumaraswami; Kate J Newberry; Richard G Brennan
Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR.
Journal of molecular biology 2010;398(2):264-75.
2010: Samuel A Shelburne; Randall J Olsen; Bryce Suber; Pranoti Sahasrabhojane; Paul Sumby; Richard G Brennan; James M Musser
A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection.
PLoS pathogens 2010;6(3):e1000817.
2010: Michiko M Nakano; Ann Lin; Cole S Zuber; Kate J Newberry; Richard G Brennan; Peter Zuber
Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit.
PloS one 2010;5(1):e8664.
2009: Todd M Link; Poul Valentin-Hansen; Richard G Brennan
Structure of Escherichia coli Hfq bound to polyriboadenylate RNA.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(46):19292-7.
2009: Kate E Stoll; William E Draper; Joseph I Kliegman; Misha V Golynskiy; Rhoda A T Brew-Appiah; Rebecca K Phillips; Hattie K Brown; Wendy A Breyer; Nicholas S Jakubovics; Howard F Jenkinson; Richard G Brennan; Seth M Cohen; Arthur Glasfeld
Characterization and structure of the manganese-responsive transcriptional regulator ScaR.
Biochemistry 2009;48(43):10308-20.
2009: Karl A Hassan; Zhiqiang Xu; Ryan E Watkins; Richard G Brennan; Ronald A Skurray; Melissa H Brown
Optimized production and analysis of the staphylococcal multidrug efflux protein QacA.
Protein expression and purification 2009;64(2):118-24.
2009: Muthiah Kumaraswami; Jason T Schuman; Susan M Seo; Glenn W Kaatz; Richard G Brennan
Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.
Nucleic acids research 2009;37(4):1211-24.
2009: Maria A Schumacher; Kevin M Piro; Weijun Xu; Sonja Hansen; Kim Lewis; Richard G Brennan
Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
Science (New York, N.Y.) 2009;323(5912):396-401.
2008: Kate J Newberry; Joy L Huffman; Marshall C Miller; Nora C Vazquez-Laslop; Alex A Neyfakh; Richard G Brennan
Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion.
The Journal of biological chemistry 2008;283(39):26795-804.
2008: Kate M Peters; Jason T Schuman; Ronald A Skurray; Marion H Brown; Richard G Brennan; Maria A Schumacher
QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization.
Biochemistry 2008;47(31):8122-9.
2007: Kate J Newberry; Mayuree Fuangthong; Warunya Panmanee; skorn Mongkolsuk; Richard G Brennan
Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR.
Molecular cell 2007;28(4):652-64.
2007: Benjamin E Brooks; Kevin M Piro; Richard G Brennan
Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions.
Journal of the American Chemical Society 2007;129(26):8389-95.
2007: Maria A Schumacher; Gerald Seidel; Wolfgang Hillen; Richard G Brennan
Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate.
Journal of molecular biology 2007;368(4):1042-50.
2007: Richard G Brennan; Todd M Link
Hfq structure, function and ligand binding.
Current opinion in microbiology 2007;10(2):125-33.
2007: Mark A DeWitt; Joseph I Kliegman; John Helmann; Richard G Brennan; David L Farrens; Arthur Glasfeld
The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state.
Journal of molecular biology 2007;365(5):1257-65.
2006: Kirsten Mattison; J Scott Wilbur; Magdalene So; Richard G Brennan
Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.
The Journal of biological chemistry 2006;281(49):37942-51.
2006: Joseph I Kliegman; Sarah L Griner; John Helmann; Richard G Brennan; Arthur Glasfeld
Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis.
Biochemistry 2006;45(11):3493-505.
2006: Maria A Schumacher; Gerald Seidel; Wolfgang Hillen; Richard G Brennan
Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation.
The Journal of biological chemistry 2006;281(10):6793-800.
2005: Kate J Newberry; Shunji Nakano; Peter Zuber; Richard G Brennan
Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15839-44.
2005: Minsun Hong; Mayuree Fuangthong; John Helmann; Richard G Brennan
Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family.
Molecular cell 2005;20(1):131-41.
2005: J Scott Wilbur; Peter T Chivers; Kirsten Mattison; Laura Potter; Richard G Brennan; Magdalene So
Neisseria gonorrhoeae FitA interacts with FitB to bind DNA through its ribbon-helix-helix motif.
Biochemistry 2005;44(37):12515-24.
2005: Katherine M Hoffmann; Daniel Williams; William M Shafer; Richard G Brennan
Characterization of the multiple transferable resistance repressor, MtrR, from Neisseria gonorrhoeae.
Journal of bacteriology 2005;187(14):5008-12.
2004: Maria A Schumacher; Gregory S Allen; Marco Diel; Gerald Seidel; Wolfgang Hillen; Richard G Brennan
Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P.
Cell 2004;118(6):731-41.
2004: Maria A Schumacher; Marshall C Miller; Richard G Brennan
Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein.
The EMBO journal 2004;23(15):2923-30.
2004: Kate J Newberry; Richard G Brennan
The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus.
The Journal of biological chemistry 2004;279(19):20356-62.
2004: David S Murray; Maria A Schumacher; Richard G Brennan
Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.
The Journal of biological chemistry 2004;279(14):14365-71.
2003: Arthur Glasfeld; Emmanuel Guedon; John Helmann; Richard G Brennan
Structure of the manganese-bound manganese transport regulator of Bacillus subtilis.
Nature structural biology 2003;10(8):652-7.
2003: Maria A Schumacher; Richard G Brennan
Deciphering the molecular basis of multidrug recognition: crystal structures of the Staphylococcus aureus multidrug binding transcription regulator QacR.
Research in microbiology 2003;154(2):69-77.
2003: Gregory S Allen; Katrin Steinhauer; Wolfgang Hillen; Jörg Stülke; Richard G Brennan
Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae.
Journal of molecular biology 2003;326(4):1203-17.
2002: Michael Godsey; Ekaterina E Zheleznova Heldwein; Richard G Brennan
Structural biology of bacterial multidrug resistance gene regulators.
The Journal of biological chemistry 2002;277(43):40169-72.
2002: Maria A Schumacher; Richard G Brennan
Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors.
Molecular microbiology 2002;45(4):885-93.
2002: Maria A Schumacher; Robert F Pearson; Thorleif Møller; Poul Valentin-Hansen; Richard G Brennan
Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein.
The EMBO journal 2002;21(13):3546-56.
2002: Caleb J Bashor; John M Denu; Richard G Brennan; Buddy Ullman
Kinetic mechanism of adenine phosphoribosyltransferase from Leishmania donovani.
Biochemistry 2002;41(12):4020-31.
2002: Maria A Schumacher; Marshall C Miller; Steve Grkovic; Marion H Brown; Ronald A Skurray; Richard G Brennan
Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR.
The EMBO journal 2002;21(5):1210-8.
2002: Katrin Steinhauer; Gregory S Allen; Wolfgang Hillen; Jörg Stülke; Richard G Brennan
Crystallization, preliminary X-ray analysis and biophysical characterization of HPr kinase/phosphatase of Mycoplasma pneumoniae.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 3):515-8.
2002: Joy L Huffman; Richard G Brennan
Prokaryotic transcription regulators: more than just the helix-turn-helix motif.
Current opinion in structural biology 2002;12(1):98-106.
2002: Joy L Huffman; Fu Lu; Howard Zalkin; Richard G Brennan
Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
Biochemistry 2002;41(2):511-20.
2002: Maria A Schumacher; Caleb J Bashor; Minsun Hong Song; Kanao Otsu; Shuren Zhu; Ronald J Parry; Buddy Ullman; Richard G Brennan
The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):78-83.
2002: Thorleif Møller; Thomas Franch; Peter Højrup; Douglas R Keene; Hans Peter Bächinger; Richard G Brennan; Poul Valentin-Hansen
Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction.
Molecular cell 2002;9(1):23-30.
2001: Michael Godsey; Natalya N Baranova; Alex A Neyfakh; Richard G Brennan
Crystal structure of MtaN, a global multidrug transporter gene activator.
The Journal of biological chemistry 2001;276(50):47178-84.
2001: Maria A Schumacher; Marshall C Miller; Steve Grkovic; Marion H Brown; Ronald A Skurray; Richard G Brennan
Structural mechanisms of QacR induction and multidrug recognition.
Science (New York, N.Y.) 2001;294(5549):2158-63.
2001: Steve Grkovic; Marion H Brown; Maria A Schumacher; Richard G Brennan; Ronald A Skurray
The staphylococcal QacR multidrug regulator binds a correctly spaced operator as a pair of dimers.
Journal of bacteriology 2001;183(24):7102-9.
2001: Joy L Huffman; A Mokashi; Hans Peter Bächinger; Richard G Brennan
The basic helix-loop-helix domain of the aryl hydrocarbon receptor nuclear transporter (ARNT) can oligomerize and bind E-box DNA specifically.
The Journal of biological chemistry 2001;276(44):40537-44.
2001: J C Craig; Maria A Schumacher; Steven E Mansoor; David L Farrens; Richard G Brennan; Richard H Goodman
Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties.
The Journal of biological chemistry 2001;276(15):11719-28.
2001: E E Heldwein; Richard G Brennan
Crystal structure of the transcription activator BmrR bound to DNA and a drug.
Nature 2001;409(6818):378-82.
2001: Maria A Schumacher; Barry K Hurlburt; Richard G Brennan
Crystal structures of SarA, a pleiotropic regulator of virulence genes in S. aureus.
Nature 2001;409(6817):215-9.
2000: Maria A Schumacher; Richard H Goodman; Richard G Brennan
The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding.
The Journal of biological chemistry 2000;275(45):35242-7.
2000: Michael Godsey; Natalya N Baranova; Alex A Neyfakh; Richard G Brennan
Crystallization and preliminary X-ray diffraction studies on the DNA-binding domain of the multidrug transporter activation protein (MtaN) from Bacillus subtilis.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1456-8.
2000: EE Zheleznova; Jorge H Crosa; Richard G Brennan
Characterization of the DNA- and metal-binding properties of Vibrio anguillarum fur reveals conservation of a structural Zn(2+) ion.
Journal of bacteriology 2000;182(21):6264-7.
2000: McKay Brown; Maria A Schumacher; gregory wiens; Richard G Brennan; Marvin B Rittenberg
The structural basis of repertoire shift in an immune response to phosphocholine.
The Journal of experimental medicine 2000;191(12):2101-12.
2000: Maria A Schumacher; DM Scott; I I Mathews; S E Ealick; DS Roos; Buddy Ullman; Richard G Brennan
Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
Journal of molecular biology 2000;298(5):875-93.
2000: Jean-René Cardinaux; J C Notis; Qinghong Zhang; Ngan Vo; J C Craig; Daniel M Fass; Richard G Brennan; Richard H Goodman
Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation.
Molecular and cellular biology 2000;20(5):1546-52.
2000: Maria A Schumacher; DM Scott; I I Mathews; S E Ealick; DS Roos; Buddy Ullman; Richard G Brennan
Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
Journal of molecular biology 2000;296(2):549-67.
1999: Arthur Glasfeld; A N Koehler; Maria A Schumacher; Richard G Brennan
The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions.
Journal of molecular biology 1999;291(2):347-61.
1999: TM Rechtin; Allison F Gillaspy; Maria A Schumacher; Richard G Brennan; Mark S Smeltzer; Barry K Hurlburt
Characterization of the SarA virulence gene regulator of Staphylococcus aureus.
Molecular microbiology 1999;33(2):307-16.
1999: C L Phillips; Buddy Ullman; Richard G Brennan; Christopher P Hill
Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani.
The EMBO journal 1999;18(13):3533-45.
1999: EE Zheleznova; PN Markham; Alex A Neyfakh; Richard G Brennan
Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter.
Cell 1999;96(3):353-62.
1998: F Lu; Richard G Brennan; Howard Zalkin
Escherichia coli purine repressor: key residues for the allosteric transition between active and inactive conformations and for interdomain signaling.
Biochemistry 1998;37(45):15680-90.
1998: James R Lundblad; Roland P S Kwok; M E Laurance; M S Huang; J P Richards; Richard G Brennan; Richard H Goodman
The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove.
The Journal of biological chemistry 1998;273(30):19251-9.
1998: Maria A Schumacher; Darrick Carter; DM Scott; DS Roos; Buddy Ullman; Richard G Brennan
Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.
The EMBO journal 1998;17(12):3219-32.
1998: Dennis N Arvidson; F Lu; C Faber; Howard Zalkin; Richard G Brennan
The structure of PurR mutant L54M shows an alternative route to DNA kinking.
Nature structural biology 1998;5(6):436-41.
1998: F Lu; Maria A Schumacher; Dennis N Arvidson; Andreas Haldimann; Barry L Wanner; Howard Zalkin; Richard G Brennan
Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190.
Biochemistry 1998;37(4):971-82.
1997: EE Zheleznova; PN Markham; Alex A Neyfakh; Richard G Brennan
Preliminary structural studies on the multi-ligand-binding domain of the transcription activator, BmrR, from Bacillus subtilis.
Protein science : a publication of the Protein Society 1997;6(11):2465-8.
1997: Maria A Schumacher; Arthur Glasfeld; Howard Zalkin; Richard G Brennan
The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity.
The Journal of biological chemistry 1997;272(36):22648-53.
1997: Maria A Schumacher; EE Zheleznova; K S Poundstone; R Kluger; Richard T Jones; Richard G Brennan
Allosteric intermediates indicate R2 is the liganded hemoglobin end state.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):7841-4.
1996: Maria A Schumacher; Darrick Carter; Buddy Ullman; D S Roos; Richard G Brennan
Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop.
Nature structural biology 1996;3(10):881-7.
1996: C L Phillíps; Buddy Ullman; Richard G Brennan
Crystallization of the purine salvage enzyme adenine phosphoribosyltransferase.
Proteins 1996;25(4):510-3.
1996: J P Richards; Hans Peter Bächinger; Richard H Goodman; Richard G Brennan
Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB.
The Journal of biological chemistry 1996;271(23):13716-23.
1996: Mitchell Lewis; Geoffrey A. Chang; N C Horton; M A Kercher; H C Pace; Maria A Schumacher; Richard G Brennan; Ponzy Lu
Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science (New York, N.Y.) 1996;271(5253):1247-54.
1995: Aritaka Nagadoi; S Morikawa; H Nakamura; M Enari; K Kobayashi; H Yamamoto; G Sampei; K Mizobuchi; Maria A Schumacher; Richard G Brennan
Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain.
Structure (London, England : 1993) 1995;3(11):1217-24.
1995: Maria A Schumacher; Kang-Yell Choi; F Lu; H Zalkin; Richard G Brennan
Mechanism of corepressor-mediated specific DNA binding by the purine repressor.
Cell 1995;83(1):147-55.
1995: Maria A Schumacher; M M Dixon; Ronald Kluger; Richard T Jones; Richard G Brennan
Allosteric transition intermediates modelled by crosslinked haemoglobins.
Nature 1995;375(6526):84-7.
1995: Aritaka Nagadoi; K Nakazawa; S Morikawa; H Nakamura; G Sampei; K Mizobuchi; H Yamamoto; Maria A Schumacher; Richard G Brennan; Yoshifumi Nishimura
Conformational changes of purine repressor DNA-binding domain upon complexation with DNA.
Nucleic acids symposium series 1995;(34):63-4.
1994: D A Brickey; J G Bann; Y L Fong; L Perrino; Richard G Brennan; Thomas R Soderling
Mutational analysis of the autoinhibitory domain of calmodulin kinase II.
The Journal of biological chemistry 1994;269(46):29047-54.
1994: Marc Loriaux; Richard G Brennan; Richard H Goodman
Modulatory function of CREB.CREM alpha heterodimers depends upon CREM alpha phosphorylation.
The Journal of biological chemistry 1994;269(46):28839-43.
1994: Maria A Schumacher; Kang-Yell Choi; H Zalkin; Richard G Brennan
Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices.
Science (New York, N.Y.) 1994;266(5186):763-70.
1994: Maria A Schumacher; Kang-Yell Choi; H Zalkin; Richard G Brennan
Crystallization and preliminary X-ray analysis of an Escherichia coli purine repressor-hypoxanthine-DNA complex.
Journal of molecular biology 1994;242(3):302-5.
1994: Roland P S Kwok; James R Lundblad; J C Chrivia; J P Richards; Hans Peter Bächinger; Richard G Brennan; S G Roberts; M R Green; Richard H Goodman
Nuclear protein CBP is a coactivator for the transcription factor CREB.
Nature 1994;370(6486):223-6.
1993: Marc Loriaux; R P Rehfuss; Richard G Brennan; Richard H Goodman
Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9046-50.
1993: Richard G Brennan
The winged-helix DNA-binding motif: another helix-turn-helix takeoff.
Cell 1993;74(5):773-6.
1993: Maria A Schumacher; J R Macdonald; J Björkman; S L Mowbray; Richard G Brennan
Structural analysis of the purine repressor, an Escherichia coli DNA-binding protein.
The Journal of biological chemistry 1993;268(17):12282-8.
1993: Craig Spiro; J P Richards; S Chandrasekaran; Richard G Brennan; Cynthia T McMurray
Secondary structure creates mismatched base pairs required for high-affinity binding of cAMP response element-binding protein to the human enkephalin enhancer.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4606-10.
1992: K P Wilson; L M Shewchuk; Richard G Brennan; A J Otsuka; Brian W Matthews
Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9257-61.
1992: Maria A Schumacher; Kang-Yell Choi; H Zalkin; Richard G Brennan
Crystallization and preliminary X-ray studies on the co-repressor binding domain of the Escherichia coli purine repressor.
Journal of molecular biology 1992;225(4):1131-3.
1991: M M Dixon; Richard G Brennan; Brian W Matthews
Structure of gamma-chymotrypsin in the range pH 2.0 to pH 10.5 suggests that gamma-chymotrypsin is a covalent acyl-enzyme adduct at low pH.
International journal of biological macromolecules 1991;13(2):89-96.
1990: Richard G Brennan; Steven L Roderick; Y Takeda; Brian W Matthews
Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):8165-9.
1989: Richard G Brennan; Brian W Matthews
The helix-turn-helix DNA binding motif.
The Journal of biological chemistry 1989;264(4):1903-6.
1989: Richard G Brennan; S Vasu; Brian W Matthews; A J Otsuka
Crystallization of the bifunctional biotin operon repressor.
The Journal of biological chemistry 1989;264(1):5.