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Chaodong Wu

Research Profile

Chemicals & Drugs

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Insulin Resistance

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Publications

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Weiyu Zhang; Jianguo Wang; Huan Wang; Rong Tang; John D Belcher; Benoit Viollet; Jian-Guo Geng; Chunxiang Zhang; Chaodong Wu; Arne Slungaard; Chuhong Zhu; Yuqing Huo
Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.
Huan Wang; Weiyu Zhang; Rong Tang; Chuhong Zhu; christoph bucher; Bruce R Blazar; Jian-Guo Geng; Chunxiang Zhang; Joel Linden; Chaodong Wu; Yuqing Huo
Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice.
Yuqing Huo; Xin Guo; Honggui Li; Huan Wang; Weiyu Zhang; Ying Wang; Huaijun Zhou; Zhanguo Gao; Sucheta Telang; Jason Chesney; Chen Lab; Jianping Ye; Robert S Chapkin; Chaodong Wu
Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response.

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All Publications

2010: Weiyu Zhang; Jianguo Wang; Huan Wang; Rong Tang; John D Belcher; Benoit Viollet; Jian-Guo Geng; Chunxiang Zhang; Chaodong Wu; Arne Slungaard; Chuhong Zhu; Yuqing Huo
Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(5):1000-6.
2010: Huan Wang; Weiyu Zhang; Rong Tang; Chuhong Zhu; christoph bucher; Bruce R Blazar; Jian-Guo Geng; Chunxiang Zhang; Joel Linden; Chaodong Wu; Yuqing Huo
Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(5):915-22.
2010: Yuqing Huo; Xin Guo; Honggui Li; Huan Wang; Weiyu Zhang; Ying Wang; Huaijun Zhou; Zhanguo Gao; Sucheta Telang; Jason Chesney; Chen Lab; Jianping Ye; Robert S Chapkin; Chaodong Wu
Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response.
The Journal of biological chemistry 2010;285(6):3713-21.
2009: Huan Wang; Weiyu Zhang; Chuhong Zhu; christoph bucher; Bruce R Blazar; Chunxiang Zhang; Jiang-Fan Chen; Joel Linden; Chaodong Wu; Yuqing Huo
Inactivation of the adenosine A2A receptor protects apolipoprotein E-deficient mice from atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(7):1046-52.
2007: W Ed Smith; Sara Langer; Chaodong Wu; Simone Baltrusch; David A Okar
Molecular coordination of hepatic glucose metabolism by the 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase:glucokinase complex.
Molecular endocrinology (Baltimore, Md.) 2007;21(6):1478-87.
2006: Chaodong Wu; Salmaan A Khan; Li-Jen Peng; Honggui Li; Steven G Carmella; Alex J Lange
Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E536-43.
2006: Chaodong Wu; Salmaan A Khan; Li-Jen Peng; Alex J Lange
Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes.
Advances in enzyme regulation 2006;46():72-88.
2005: Chaodong Wu; Salmaan A Khan; Alex J Lange
Regulation of glycolysis-role of insulin.
Experimental gerontology 2005;40(11):894-9.
2005: Colleen M Niswender; Brandon S Willis; Angela R Wallen; Ian R Sweet; Thomas L Jetton; Brian R Thompson; Chaodong Wu; Alex J Lange; G Stanley McKnight
Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.
Genesis (New York, N.Y. : 2000) 2005;43(3):109-19.
2005: Chaodong Wu; Johnthomas E Kang; Li-Jen Peng; Honggui Li; Salmaan A Khan; Christopher J Hillard; David A Okar; Alex J Lange
Enhancing hepatic glycolysis reduces obesity: differential effects on lipogenesis depend on site of glycolytic modulation.
Cell metabolism 2005;2(2):131-40.
2005: Victoria A Payne; Catherine Arden; Chaodong Wu; Alex J Lange; Loranne Agius
Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes.
Diabetes 2005;54(7):1949-57.
2005: Chaodong Wu; David A Okar; Johnthomas Kang; Alex J Lange
Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes.
Current drug targets. Immune, endocrine and metabolic disorders 2005;5(1):51-9.
2005: Rachel A Baar; Carlus S Dingfelder; Lisa A Smith; David A Bernlohr; Chaodong Wu; Alex J Lange; Elizabeth J Parks
Investigation of in vivo fatty acid metabolism in AFABP/aP2(-/-) mice.
American journal of physiology. Endocrinology and metabolism 2005;288(1):E187-93.
2004: Rajakumar V Donthi; Gang Ye; Chaodong Wu; Donald A McClain; Alex J Lange; Paul N Epstein
Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity.
The Journal of biological chemistry 2004;279(46):48085-90.
2004: Chaodong Wu; David A Okar; Angela K Stoeckman; Li-Jen Peng; Amy H Herrera; Julio E Herrera; Howard C Towle; Alex J Lange
A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.
Endocrinology 2004;145(2):650-8.
2004: David A Okar; Chaodong Wu; Alex J Lange
Regulation of the regulatory enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Advances in enzyme regulation 2004;44():123-54.
2002: In-Young Choi; Chaodong Wu; David A Okar; Alex J Lange; Rolf Gruetter
Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo (13)C NMR measurements of hepatic carbohydrate metabolism.
European journal of biochemistry / FEBS 2002;269(18):4418-26.
2002: Chaodong Wu; David A Okar; Christopher B Newgard; Alex J Lange
Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2002;282(1):E38-45.
2001: Chaodong Wu; David A Okar; Christopher B Newgard; Alex J Lange
Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production.
The Journal of clinical investigation 2001;107(1):91-8.