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David Brenner

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Bernd Schnabl; David A Brenner
Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis.
Tatiana Kisseleva; David A Brenner
Inactivation of myofibroblasts during regression of liver fibrosis.
Kouichi Miura; Hirohide Ohnishi; Nico van Rooijen; Ling Yang; David A Brenner; Ekihiro Seki
Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice.

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All Publications

2013: Bernd Schnabl; David A Brenner
Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis.
Gut 2013;62(3):335-6.
2013: Tatiana Kisseleva; David A Brenner
Inactivation of myofibroblasts during regression of liver fibrosis.
Cell cycle (Georgetown, Tex.) 2013;12(3):381-2.
2013: Kouichi Miura; Hirohide Ohnishi; Nico van Rooijen; Ling Yang; David A Brenner; Ekihiro Seki
Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice.
Hepatology (Baltimore, Md.) 2013;57(2):577-89.
2012: Tomonori Aoyama; Laetitia Fioraso-Cartier; Francesca Gaggini; Freddy Heitz; Benoît Laleu; Cédric Merlot; Sophie Molango; Patrick Page; Yong Han Paik; Cédric Szyndralewiez; Sumio Watanabe; David A Brenner
Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent.
Hepatology (Baltimore, Md.) 2012;56(6):2316-27.
2012: Phillipp Hartmann; Magdalena Mazagova; David A Brenner; Michael Haimerl; Bernd Schnabl
Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice.
Gastroenterology 2012;143(5):1330-40.e1.
2012: Fanli Meng; Christoph H Osterreicher; Yonghan Paik; David Scholten; Felix Stickel; Kai Wang; Mingjun Zhang; Tomonori Aoyama; David A Brenner; Min Cong; Sergei I Grivennikov; Keiko Iwaisako; Klaus Ley; Xiao Liu; Tatiana Kisseleva
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice.
Gastroenterology 2012;143(3):765-76.e1-3.
2012: Tsuyoshi Hirota; Keiko Iwaisako; David A Brenner; Francis J Doyle; Jae Wook Lee; Takako Noguchi; Pagkapol Y Pongsawakul; Mariko Sawa; Peter G Schultz; Tim Sonntag; Peter C St John; David K Welsh; Steve A Kay
Identification of small molecule activators of cryptochrome.
Science (New York, N.Y.) 2012;337(6098):1094-7.
2012: Ekihiro Seki; David A Brenner; Michael Karin
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.
Gastroenterology 2012;143(2):307-20.
2012: Tatiana Kisseleva; Thomas Moore-Morris; Yonghan Paik; David Scholten; Brian Scott; Hidekazu Tsukamoto; Min Cong; Wolfgang Dillmann; Sylvia M Evans; Christopher K Glass; Keiko Iwaisako; Chunyan Jiang; Chris Benner; David A Brenner
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(24):9448-53.
2012: Keiko Iwaisako; Yuzo Kodama; Yong Han Paik; David A Brenner; Michael Downes; Ronald M Evans; Michael Haimerl; Claude Sirlin; Kojiro Taura; Elizabeth Yu; Ruth T Yu; Bernd Schnabl
Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(21):E1369-76.
2012: Tatiana Kisseleva; David A Brenner
The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis.
Journal of hepatology 2012;56(4):965-72.
2012: Keiko Iwaisako; David A Brenner; Tatiana Kisseleva
What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis.
Journal of gastroenterology and hepatology 2012;27 Suppl 2():65-8.
2012: Mamie H Dong; Elizabeth Barrett-Connor; Ricki Bettencourt; David A Brenner; Rohit Loomba
Serum levels of alanine aminotransferase decrease with age in longitudinal analysis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2012;10(3):285-90.e1.
2011: Tatiana Kisseleva; Mitchell Kronenberg; Shauna M McGillvray; Victor Nizet; Donna Reichart; Maren von Köckritz-Blickwede; Gerhard Wingender; Christopher K Glass; David A Brenner
Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection.
Journal of molecular medicine (Berlin, Germany) 2011;89(10):997-1013.
2011: David Scholten; Jens Lindert; Yong Han Paik; Donna Reichart; Jahar Bhattacharya; David A Brenner; Christopher K Glass; Tatiana Kisseleva
Migration of fibrocytes in fibrogenic liver injury.
The American journal of pathology 2011;179(1):189-98.
2011: Tatiana Kisseleva; David A Brenner
Is it the end of the line for the EMT?
Hepatology (Baltimore, Md.) 2011;53(5):1433-5.
2011: Yong Han Paik; Keiko Iwaisako; Ekihiro Seki; Sayaka Inokuchi; Bernd Schnabl; Christoph H Osterreicher; Tatiana Kisseleva; David A Brenner
The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice.
Hepatology (Baltimore, Md.) 2011;53(5):1730-41.
2011: Tatiana Kisseleva; David A Brenner
Anti-fibrogenic strategies and the regression of fibrosis.
Best practice & research. Clinical gastroenterology 2011;25(2):305-17.
2011: Bin Gao; Ekihiro Seki; David A Brenner; Scott Friedman; Jessica I Cohen; Laura Nagy; Gyongyi Szabo; Samir Zakhari
Innate immunity in alcoholic liver disease.
American journal of physiology. Gastrointestinal and liver physiology 2011;300(4):G516-25.
2011: Christoph H Österreicher; Melitta Penz-Österreicher; Sergei I Grivennikov; Monica Guma; Ekaterina K Koltsova; Christian Datz; Roman Sasik; Hardiman Gary; Michael Karin; David A Brenner
Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):308-13.
2010: Samuele De Minicis; Ekihiro Seki; Yong-Han Paik; Christoph H Osterreicher; Yuzo Kodama; Johannes Kluwe; Luciano Torozzi; Katsumi Miyai; Antonio Benedetti; Robert F Schwabe; David A Brenner
Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis.
Hepatology (Baltimore, Md.) 2010;52(4):1420-30.
2010: Tomonori Aoyama; Sayaka Inokuchi; David A Brenner; Ekihiro Seki
CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice.
Hepatology (Baltimore, Md.) 2010;52(4):1390-400.
2010: David Scholten; Christoph H Osterreicher; Anjali Scholten; Keiko Iwaisako; Guoqiang Gu; David A Brenner; Tatiana Kisseleva
Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice.
Gastroenterology 2010;139(3):987-98.
2010: Rohit Loomba; Fangwen Rao; Lian Zhang; Srikrishna Khandrika; Michael G Ziegler; David A Brenner; Daniel T O'Connor
Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins.
Gastroenterology 2010;139(3):836-45, 845.e1.
2010: Kouichi Miura; Yuzo Kodama; Sayaka Inokuchi; Bernd Schnabl; Tomonori Aoyama; Hirohide Ohnishi; Jerrold M Olefsky; David A Brenner; Ekihiro Seki
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice.
Gastroenterology 2010;139(1):323-34.e7.
2010: Kojiro Taura; Kouichi Miura; Keiko Iwaisako; Christoph H Osterreicher; Yuzo Kodama; Melitta Penz-Osterreicher; David A Brenner
Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice.
Hepatology (Baltimore, Md.) 2010;51(3):1027-36.
2010: Montserrat Moreno; Teresa Gonzalo; Robbert J Kok; Pau Sancho-Bru; Marike van Beuge; Josine Swart; Jai Prakash; Kai Temming; Constantino Fondevila; Leonie Beljaars; Marie Lacombe; Paul van der Hoeven; Vicente Arroyo; Klaas Poelstra; David A Brenner; Pere Ginès; Ramón Bataller
Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats.
Hepatology (Baltimore, Md.) 2010;51(3):942-52.
2010: Zhi Zhong; Shigeki Tsukada; Hasibur Rehman; Christopher J Parsons; Tom Theruvath; Richard A Rippe; David A Brenner; John J Lemasters
Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2010;16(2):181-90.
2010: Sayaka Inokuchi; Tomonori Aoyama; Kouichi Miura; Christoph H Osterreicher; Yuzo Kodama; Katsumi Miyai; Shizuo Akira; David A Brenner; Ekihiro Seki
Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):844-9.
2010: Pau Sancho-Bru; Elena Juez; Montserrat Moreno; Valeria Khurdayan; Manuel Morales-Ruiz; Jordi Colmenero; Vicente Arroyo; David A Brenner; Pere Ginès; Ramón Bataller
Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells.
Liver international : official journal of the International Association for the Study of the Liver 2010;30(1):31-41.
2009: Yong Han Paik; J K Kim; Joung Il Lee; S H Kang; D Y Kim; S H An; Se-Jun Lee; Dong Ki Lee; Kwang-Hyub Han; Chae Yoon Chon; SI Lee; Kkot Sil Lee; David A Brenner
Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats.
Gut 2009;58(11):1517-27.
2009: Jordi Colmenero; Ramón Bataller; Pau Sancho-Bru; Marlene Domínguez; Montserrat Moreno; Xavier Forns; Miquel Bruguera; Vicente Arroyo; David A Brenner; Pere Ginès
Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C.
American journal of physiology. Gastrointestinal and liver physiology 2009;297(4):G726-34.
2009: Yuzo Kodama; Tatiana Kisseleva; Keiko Iwaisako; Kouichi Miura; Kojiro Taura; Samuele De Minicis; Christoph H Osterreicher; Bernd Schnabl; Ekihiro Seki; David A Brenner
c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice.
Gastroenterology 2009;137(4):1467-1477.e5.
2009: David A Brafman; Samuele De Minicis; Ekihiro Seki; Kevan D Shah; Dayu Teng; David A Brenner; Karl Willert; Shu Chien
Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments.
Integrative biology : quantitative biosciences from nano to macro 2009;1(8-9):513-24.
2009: Christoph H Osterreicher; Kojiro Taura; Samuele De Minicis; Ekihiro Seki; Melitta Penz-Osterreicher; Yuzo Kodama; Johannes Kluwe; Manfred Schuster; Gavin Y Oudit; Josef M Penninger; David A Brenner
Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice.
Hepatology (Baltimore, Md.) 2009;50(3):929-38.
2009: Ekihiro Seki; Samuele De Minicis; Geum-Youn Gwak; Johannes Kluwe; Sayaka Inokuchi; Christina A Bursill; Josep M Llovet; David A Brenner; Robert F Schwabe
CCR1 and CCR5 promote hepatic fibrosis in mice.
The Journal of clinical investigation 2009;119(7):1858-70.
2009: Ekihiro Seki; Samuele De Minicis; Sayaka Inokuchi; Kojiro Taura; Katsumi Miyai; Nico van Rooijen; Robert F Schwabe; David A Brenner
CCR2 promotes hepatic fibrosis in mice.
Hepatology (Baltimore, Md.) 2009;50(1):185-97.
2009: Yuzo Kodama; Kojiro Taura; Kouichi Miura; Bernd Schnabl; Yosuke Osawa; David A Brenner
Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis.
Gastroenterology 2009;136(4):1423-34.
2009: Katharina Brandl; Sophie Rutschmann; Xiaohong Li; Xin Du; Nengming Xiao; Bernd Schnabl; David A Brenner; Bruce Beutler
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3300-5.
2009: Erwin Gäbele; Matthias Froh; Gavin E Arteel; Takehiko Uesugi; Claus Hellerbrand; Jürgen Schölmerich; David A Brenner; Ronald G Thurman; Richard A Rippe
TNFalpha is required for cholestasis-induced liver fibrosis in the mouse.
Biochemical and biophysical research communications 2009;378(3):348-53.
2009: David A Brenner
Molecular pathogenesis of liver fibrosis.
Transactions of the American Clinical and Climatological Association 2009;120():361-8.
2009: David H Adler; John A Phillips; Joy D Cogan; Tina M Iverson; Nathalie Schnetz-Boutaud; Jeffrey A Stein; David A Brenner; Ginger L Milne; Jason D Morrow; Olivier Boutaud; John A Oates
The enteropathy of prostaglandin deficiency.
Journal of gastroenterology 2009;44 Suppl 19():1-7.
2009: Yuzo Kodama; David A Brenner
c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps.
Hepatology (Baltimore, Md.) 2009;49(1):6-8.
2009: George Notas; Tatiana Kisseleva; David A Brenner
NK and NKT cells in liver injury and fibrosis.
Clinical immunology (Orlando, Fla.) 2009;130(1):16-26.
2008: Samuele De Minicis; Ekihiro Seki; Christoph Oesterreicher; Bernd Schnabl; Robert F Schwabe; David A Brenner
Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells.
Hepatology (Baltimore, Md.) 2008;48(6):2016-26.
2008: Shuei-Liong Lin; Tatiana Kisseleva; David A Brenner; Jeremy S Duffield
Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney.
The American journal of pathology 2008;173(6):1617-27.
2008: Kojiro Taura; Samuele De Minicis; Ekihiro Seki; Etsuro Hatano; Keiko Iwaisako; Christoph H Osterreicher; Yuzo Kodama; Kouichi Miura; Iwao Ikai; Shinji Uemoto; David A Brenner
Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis.
Gastroenterology 2008;135(5):1729-38.
2008: Kouichi Miura; Kojiro Taura; Yuzo Kodama; Bernd Schnabl; David A Brenner
Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity.
Hepatology (Baltimore, Md.) 2008;48(5):1420-9.
2008: Bernd Schnabl; David Scholten; David A Brenner
What is the potential role of antifibrotic agents for the treatment of liver disease?
Nature clinical practice. Gastroenterology & hepatology 2008;5(9):496-7.
2008: Vishnudutt Purohit; J Christian Bode; Christiane Bode; David A Brenner; Mashkoor A Choudhry; Frank Hamilton; Y James Kang; Ali Keshavarzian; Radhakrishna Rao; Ryan Sartor; Christine Swanson; Jerrold R Turner
Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium.
Alcohol (Fayetteville, N.Y.) 2008;42(5):349-61.
2008: Ekihiro Seki; David A Brenner
Toll-like receptors and adaptor molecules in liver disease: update.
Hepatology (Baltimore, Md.) 2008;48(1):322-35.
2008: David H Adler; Joy D Cogan; John A Phillips; Nathalie Schnetz-Boutaud; Ginger L Milne; Tina Iverson; Jeffrey A Stein; David A Brenner; Jason D Morrow; Olivier Boutaud; John A Oates
Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.
The Journal of clinical investigation 2008;118(6):2121-31.
2008: Tatiana Kisseleva; David A Brenner
Fibrogenesis of parenchymal organs.
Proceedings of the American Thoracic Society 2008;5(3):338-42.
2008: Samuele De Minicis; David A Brenner
Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex.
Journal of gastroenterology and hepatology 2008;23 Suppl 1():S98-103.
2008: Tatiana Kisseleva; David A Brenner
Mechanisms of fibrogenesis.
Experimental biology and medicine (Maywood, N.J.) 2008;233(2):109-22.
2008: Masayuki Adachi; David A Brenner
High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase.
Hepatology (Baltimore, Md.) 2008;47(2):677-85.
2008: Yuji Iimuro; David A Brenner
Matrix metalloproteinase gene delivery for liver fibrosis.
Pharmaceutical research 2008;25(2):249-58.
2007: Pau Sancho-Bru; Ramón Bataller; Guillermo Fernández-Varo; Montserrat Moreno; Leandra N Ramalho; Jordi Colmenero; Montserrat Marí; Joan Clària; Wladimiro Jiménez; Vicente Arroyo; David A Brenner; Pere Ginès
Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury.
Gastroenterology 2007;133(6):2019-28.
2007: Kouichi Miura; Ryutaro Yoshino; Yohei Hirai; Takashi Goto; Shigetoshi Ohshima; Ken-Ichiro Mikami; Kazuo Yoneyama; Daisuke Watanabe; Mitsuru Sato; Haruki Senoo; Yuzo Kodama; Yosuke Osawa; David A Brenner; Sumio Watanabe
Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB.
Journal of hepatology 2007;47(6):834-43.
2007: Frank Tacke; Erwin Gäbele; Frauke Bataille; Robert F Schwabe; Claus Hellerbrand; Frank Klebl; Rainer H Straub; Tom Luedde; Michael P Manns; Christian Trautwein; David A Brenner; Jürgen Schölmerich; Bernd Schnabl
Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells.
Digestive diseases and sciences 2007;52(12):3404-15.
2007: Ekihiro Seki; Samuele De Minicis; Christoph H Osterreicher; Johannes Kluwe; Yosuke Osawa; David A Brenner; Robert F Schwabe
TLR4 enhances TGF-beta signaling and hepatic fibrosis.
Nature medicine 2007;13(11):1324-32.
2007: Ali Mencin; Ekihiro Seki; Yosuke Osawa; Yuzo Kodama; Samuele De Minicis; Michael Knowles; David A Brenner
Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis.
Hepatology (Baltimore, Md.) 2007;46(5):1443-52.
2007: Frank Tacke; Christian Trautwein; Eray Yagmur; Claus Hellerbrand; Reiner Wiest; David A Brenner; Bernd Schnabl
Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course.
Journal of gastroenterology and hepatology 2007;22(8):1256-64.
2007: Ekihiro Seki; David A Brenner
The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor?
Journal of hepatology 2007;47(2):307-9.
2007: Samuele De Minicis; David A Brenner
NOX in liver fibrosis.
Archives of biochemistry and biophysics 2007;462(2):266-72.
2007: Robert F Schwabe; David A Brenner
Nuclear factor-kappaB in the liver: friend or foe?
Gastroenterology 2007;132(7):2601-4.
2007: Tatiana Kisseleva; David A Brenner
Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis.
Journal of gastroenterology and hepatology 2007;22 Suppl 1():S73-8.
2007: Lee M Kaplan; Samuel Klein; Guenther Boden; David A Brenner; Christopher J Gostout; Joel Edward Lavine; Barry M Popkin; Bruce D Schirmer; Randy J Seeley; Susan Z Yanovski; Fabio Cominelli
Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force.
Gastroenterology 2007;132(6):2272-5.
2007: Samuele De Minicis; Ekihiro Seki; Hiroshi Uchinami; Johannes Kluwe; Yonghui Zhang; David A Brenner; Robert F Schwabe
Gene expression profiles during hepatic stellate cell activation in culture and in vivo.
Gastroenterology 2007;132(5):1937-46.
2007: Christoph H Osterreicher; David A Brenner
The genetics of nonalcoholic fatty liver disease.
Annals of hepatology 2007;6(2):83-8.
2007: Masayuki Adachi; Yosuke Osawa; Hiroshi Uchinami; Tadahiro Kitamura; Domenico Accili; David A Brenner
The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells.
Gastroenterology 2007;132(4):1434-46.
2007: Christoph H Osterreicher; Felix Stickel; David A Brenner
Genomics of liver fibrosis and cirrhosis.
Seminars in liver disease 2007;27(1):28-43.
2006: Yosuke Osawa; Ekihiro Seki; Masayuki Adachi; Kojiro Taura; Yuzo Kodama; Soeren Siegmund; Robert F Schwabe; David A Brenner
Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(9):1138-47.
2006: Pau Sancho-Bru; Ramón Bataller; Jordi Colmenero; Xavier Gasull; Montserrat Moreno; Vicente Arroyo; David A Brenner; Pere Ginès
Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(5):G877-84.
2006: Tatiana Kisseleva; David A Brenner
Hepatic stellate cells and the reversal of fibrosis.
Journal of gastroenterology and hepatology 2006;21 Suppl 3():S84-7.
2006: Yong Han Paik; David A Brenner
Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis.
Gastroenterology 2006;131(3):957-60.
2006: Tatiana Kisseleva; Hiroshi Uchinami; Nikki Feirt; Oscar Quintana-Bustamante; Jose C Segovia; Robert F Schwabe; David A Brenner
Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis.
Journal of hepatology 2006;45(3):429-38.
2006: Mark Lehnert; Tetsuya Uehara; Blair U Bradford; Henrik Lind; Zhi Zhong; David A Brenner; Ingo Marzi; John J Lemasters
Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(3):G456-63.
2006: Hiroshi Uchinami; Ekihiro Seki; David A Brenner; Jeanine D'Armiento
Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis.
Hepatology (Baltimore, Md.) 2006;44(2):420-9.
2006: Zhi Zhong; Robert F Schwabe; Yoichiro Kai; Lihua He; Liu Yang; Hartwig Bunzendahl; David A Brenner; John J Lemasters
Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply.
Transplantation 2006;82(2):241-50.
2006: Samuele De Minicis; Ramón Bataller; David A Brenner
NADPH oxidase in the liver: defensive, offensive, or fibrogenic?
Gastroenterology 2006;131(1):272-5.
2006: Yong Han Paik; Kwan Sik Lee; Hyun Jin Lee; Kyung Min Yang; Se Jun Lee; Dong Ki Lee; Kwang-Hyub Han; Chae Yoon Chon; Sang In Lee; Young Myoung Moon; David A Brenner
Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid.
Laboratory investigation; a journal of technical methods and pathology 2006;86(7):676-86.
2006: Robert F Schwabe; Ekihiro Seki; David A Brenner
Toll-like receptor signaling in the liver.
Gastroenterology 2006;130(6):1886-900.
2006: Samuel Klein; Bettina Mittendorfer; J Christopher Eagon; Bruce Patterson; Lafaine Grant; Nikki Feirt; Ekihiro Seki; David A Brenner; Kevin Korenblat; Jennifer McCrea
Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease.
Gastroenterology 2006;130(6):1564-72.
2006: David A Brenner
The future of gastroenterology and gastroenterology.
Gastroenterology 2006;130(6):1562.
2006: Thorsten G Lehmann; Tom Luedde; Robert F Schwabe; Hartwig Bunzendahl; R Jude Samulski; John J Lemasters; David A Brenner
Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2006;12(4):550-9.
2006: Robert F Schwabe; David A Brenner
Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(4):G583-9.
2006: Vishnudutt Purohit; David A Brenner
Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium.
Hepatology (Baltimore, Md.) 2006;43(4):872-8.
2005: Yosuke Osawa; Yusuf A Hannun; Richard L Proia; David A Brenner
Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver.
Hepatology (Baltimore, Md.) 2005;42(6):1320-8.
2005: Soeren Siegmund; David A Brenner
Molecular pathogenesis of alcohol-induced hepatic fibrosis.
Alcoholism, clinical and experimental research 2005;29(11 Suppl):102S-109S.
2005: Bernd Schnabl; Kanghong Hu; Marcus Mühlbauer; Claus Hellerbrand; Branko Stefanovic; David A Brenner; Jürgen Schölmerich
Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10.
Biochemical and biophysical research communications 2005;335(1):87-96.
2005: Lela Stefanovic; David A Brenner; Branko Stefanovic
Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils.
Experimental biology and medicine (Maywood, N.J.) 2005;230(8):573-86.
2005: Ramón Bataller; Pau Sancho-Bru; Pere Ginès; David A Brenner
Liver fibrogenesis: a new role for the renin-angiotensin system.
Antioxidants & redox signaling 2005;7(9-10):1346-55.
2005: Liu Yang; Scott T Magness; Ramón Bataller; Richard A Rippe; David A Brenner
NF-kappaB activation in Kupffer cells after partial hepatectomy.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(3):G530-8.
2005: Liu Yang; Ramón Bataller; Jennyfer Dulyx; Thomas M Coffman; Pere Ginès; Richard A Rippe; David A Brenner
Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.
Journal of hepatology 2005;43(2):317-23.
2005: Yosuke Osawa; Hiroshi Uchinami; Jacek Bielawski; Robert F Schwabe; Yusuf A Hannun; David A Brenner
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
The Journal of biological chemistry 2005;280(30):27879-87.
2005: Yankun Li; Robert F Schwabe; Tracie DeVries-Seimon; Pin Mei Yao; Marie-Christine Gerbod-Giannone; Alan R Tall; Roger J Davis; Richard Flavell; David A Brenner; Ira Tabas
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis.
The Journal of biological chemistry 2005;280(23):21763-72.
2005: Tetsuya Uehara; Brydon Bennett; Steve T Sakata; Yoshitaka Satoh; Graham K Bilter; John K Westwick; David A Brenner
JNK mediates hepatic ischemia reperfusion injury.
Journal of hepatology 2005;42(6):850-9.
2005: Soeren Siegmund; Hiroshi Uchinami; Yosuke Osawa; David A Brenner; Robert F Schwabe
Anandamide induces necrosis in primary hepatic stellate cells.
Hepatology (Baltimore, Md.) 2005;41(5):1085-95.
2005: Ramón Bataller; Erwin Gäbele; Christopher J Parsons; Terry Morris; Liu Yang; Robert Schoonhoven; David A Brenner; Richard A Rippe
Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats.
Hepatology (Baltimore, Md.) 2005;41(5):1046-55.
2005: Erwin Gäbele; Shimon Reif; Shigeki Tsukada; Ramón Bataller; Yutaka Yata; Terry Morris; Laura W Schrum; David A Brenner; Richard A Rippe
The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation.
The Journal of biological chemistry 2005;280(14):13374-82.
2005: Tom Luedde; Ulrike Assmus; Torsten Wüstefeld; Andreas Meyer zu Vilsendorf; Tania Roskams; Marc Schmidt-Supprian; Klaus Rajewsky; David A Brenner; Michael P Manns; Manolis Pasparakis; Christian Trautwein
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.
The Journal of clinical investigation 2005;115(4):849-59.
2005: Irvin M Modlin; Guido Adler; Kathey Alexander; Rudolf Arnold; David A Brenner; Enrico Corazziari; Martin H Floch; Ronald E LaPorte; Walter L Peterson; Eamonn M Quigley; Michael D Shapiro; Stuart Jon Spechler; Robin C Spiller; G N J Tytgat; Wolfram Wiegers
Information assimilation and distribution challenges and goals for real and virtual journals.
Journal of clinical gastroenterology 2005;39(3):181-8.
2005: Ramón Bataller; David A Brenner
Liver fibrosis.
The Journal of clinical investigation 2005;115(2):209-18.
2005: Soeren Siegmund; Steven Dooley; David A Brenner
Molecular mechanisms of alcohol-induced hepatic fibrosis.
Digestive diseases (Basel, Switzerland) 2005;23(3-4):264-74.
2005: Masayuki Adachi; David A Brenner
Clinical syndromes of alcoholic liver disease.
Digestive diseases (Basel, Switzerland) 2005;23(3-4):255-63.
2005: S Sanz; Jolanta B Pucilowska; S Liu; Carlos M Rodríguez-Ortigosa; P Kay Lund; David A Brenner; C Randall Fuller; James G Simmons; A Pardo; María L Martínez-Chantar; James A Fagin; Jesús Prieto
Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury.
Gut 2005;54(1):134-41.
2004: David A Brenner
Data from arrays: an embarrassment of riches.
Gastroenterology 2004;127(6):1659.
2004: Scott T Magness; Ramón Bataller; Liu Yang; David A Brenner
A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations.
Hepatology (Baltimore, Md.) 2004;40(5):1151-9.
2004: Christopher J Parsons; Blair U Bradford; Clark Q Pan; Ellen Cheung; Michael Schauer; Andreas Knorr; Barbara Krebs; Sabine Kraft; Stefan Zahn; Bodo Brocks; Nikki Feirt; Baisong Mei; Myung-Sam Cho; Roopa Ramamoorthi; Greg Roldan; Paul Ng; Peggy Lum; Claudia Hirth-Dietrich; Adrian Tomkinson; David A Brenner
Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats.
Hepatology (Baltimore, Md.) 2004;40(5):1106-15.
2004: Nobuko Harada; Etsuro Hatano; Naoki Koizumi; Takashi Nitta; Masanori Yoshida; Naritaka Yamamoto; David A Brenner; Yoshio Yamaoka
Akt activation protects rat liver from ischemia/reperfusion injury.
The Journal of surgical research 2004;121(2):159-70.
2004: Richard A Rippe; David A Brenner
From quiescence to activation: Gene regulation in hepatic stellate cells.
Gastroenterology 2004;127(4):1260-2.
2004: Tetsuya Uehara; Xing Xi Peng; Brydon Bennett; Yoshi Satoh; Glenn Friedman; Robert T Currin; David A Brenner; John J Lemasters
c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation.
Transplantation 2004;78(3):324-32.
2004: Scott T Magness; Humberto B Jijon; Nancy Van Houten Fisher; Norman E Sharpless; David A Brenner; Christian Jobin
In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1561-70.
2004: Dalliah Black; Mark A Bird; Melissa Hayden; Laura W Schrum; Patricia A Lange; Charles M Samson; Etsuro Hatano; Richard A Rippe; David A Brenner; Kevin E Behrns
TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein.
Surgery 2004;135(6):619-28.
2004: Dalliah Black; Mark A Bird; Charles M Samson; Suzanne Lyman; Patricia A Lange; Laura W Schrum; Ting Qian; John J Lemasters; David A Brenner; Richard A Rippe; Kevin E Behrns
Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism.
Journal of hepatology 2004;40(6):942-51.
2004: Jeffrey N Lindquist; Christopher J Parsons; Branko Stefanovic; David A Brenner
Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region.
The Journal of biological chemistry 2004;279(22):23822-9.
2004: Robert F Schwabe; Hiroshi Uchinami; Ting Qian; Brydon L Bennett; John J Lemasters; David A Brenner
Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(6):720-2.
2004: Ramón Bataller; Yong Han Paik; Jeffrey N Lindquist; John J Lemasters; David A Brenner
Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells.
Gastroenterology 2004;126(2):529-40.
2004: Branko Stefanovic; Lela Stefanovic; Bernd Schnabl; Ramón Bataller; David A Brenner
TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis.
Molecular and cellular biology 2004;24(4):1758-68.
2004: David A Brenner
Gastrointestinal basic science 2002-2003: the year in review.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2004;2(1):9-13.
2003: Ramón Bataller; Robert F Schwabe; Youkyung H Choi; Liu Yang; Yong Han Paik; Jeffrey Lindquist; Ting Qian; Robert Schoonhoven; Curt H Hagedorn; John J Lemasters; David A Brenner
NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.
The Journal of clinical investigation 2003;112(9):1383-94.
2003: Robert F Schwabe; Ramón Bataller; David A Brenner
Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(5):G949-58.
2003: Motoaki Imose; Masahito Nagaki; Takafumi Naiki; Yosuke Osawa; David A Brenner; Takahiko Asano; Hideki Hayashi; Tomohiro Kato; Hisataka Moriwaki
Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice.
Liver international : official journal of the International Association for the Study of the Liver 2003;23(5):386-96.
2003: Robert S Brown; David A Brenner
MELD and the practicing gastroenterologist.
Gastroenterology 2003;125(4):1009.
2003: Ramón Bataller; Erwin Gäbele; Robert Schoonhoven; Terry Morris; Mark Lehnert; Liu Yang; David A Brenner; Richard A Rippe
Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(3):G642-51.
2003: Thorsten G Lehmann; Michael D Wheeler; Matthias Froh; Robert F Schwabe; Hartwig Bunzendahl; R Jude Samulski; John J Lemasters; David A Brenner; Ronald G Thurman
Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat.
Transplantation 2003;76(1):28-37.
2003: Young Oh Kweon; Yong Han Paik; Bernd Schnabl; Ting Qian; John J Lemasters; David A Brenner
Gliotoxin-mediated apoptosis of activated human hepatic stellate cells.
Journal of hepatology 2003;39(1):38-46.
2003: Yong Han Paik; Robert F Schwabe; Ramón Bataller; Maria P Russo; Christian Jobin; David A Brenner
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells.
Hepatology (Baltimore, Md.) 2003;37(5):1043-55.
2003: Ki-Wan Oh; Ting Qian; David A Brenner; John J Lemasters
Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(1):44-52.
2003: Yosuke Osawa; Masahito Nagaki; Yoshiko Banno; David A Brenner; Yoshinori Nozawa; Hisataka Moriwaki; Shigeru Nakashima
Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4053-60.
2003: Tom Luedde; Maria E Rodriguez; Frank Tacke; Yue Xiong; David A Brenner; Christian Trautwein
p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver.
Hepatology (Baltimore, Md.) 2003;37(4):833-41.
2003: Robert F Schwabe; Cynthia A Bradham; Tetsuya Uehara; Etsuro Hatano; Brydon L Bennett; Robert Schoonhoven; David A Brenner
c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration.
Hepatology (Baltimore, Md.) 2003;37(4):824-32.
2003: Toshihiro Nishio; Yuji Iimuro; Takashi Nitta; Nobuko Harada; Masanori Yoshida; Tetsuro Hirose; Naritaka Yamamoto; Taisuke Morimoto; David A Brenner; Yoshio Yamaoka
Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat.
Journal of hepatology 2003;38(4):468-75.
2003: Shimon Reif; Alon Lang; Jeffrey N Lindquist; Yutaka Yata; Erwin Gabele; Andrew Scanga; David A Brenner; Richard A Rippe
The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression.
The Journal of biological chemistry 2003;278(10):8083-90.
2003: Bernd Schnabl; Carrie A Purbeck; Youkyung Hwang Choi; Curt H Hagedorn; David A Brenner
Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype.
Hepatology (Baltimore, Md.) 2003;37(3):653-64.
2003: Ramón Bataller; Kari E North; David A Brenner
Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal.
Hepatology (Baltimore, Md.) 2003;37(3):493-503.
2003: Yuji Iimuro; Toshihiro Nishio; Taisuke Morimoto; Takashi Nitta; Branko Stefanovic; Sung Kyu Choi; David A Brenner; Yoshio Yamaoka
Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat.
Gastroenterology 2003;124(2):445-58.
2003: Yutaka Yata; Andrew Scanga; Andrea Gillan; Liu Yang; Shimon Reif; Michael Breindl; David A Brenner; Richard A Rippe
DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells.
Hepatology (Baltimore, Md.) 2003;37(2):267-76.
2003: Branko Stefanovic; David A Brenner
5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo.
The Journal of biological chemistry 2003;278(2):927-33.
2003: Erwin Gäbele; David A Brenner; Richard A Rippe
Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell.
Frontiers in bioscience : a journal and virtual library 2003;8():d69-77.
2002: Young-Soo Kim; Robert F Schwabe; Ting Qian; John J Lemasters; David A Brenner
TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells.
Hepatology (Baltimore, Md.) 2002;36(6):1498-508.
2002: Yosuke Osawa; Masahito Nagaki; Yoshiko Banno; David A Brenner; Takahiko Asano; Yoshinori Nozawa; Hisataka Moriwaki; Shigeru Nakashima
Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes.
Infection and immunity 2002;70(11):6294-301.
2002: John J Lemasters; Ting Qian; Lihua He; Jae-Sung Kim; Steven P Elmore; Wayne E Cascio; David A Brenner
Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy.
Antioxidants & redox signaling 2002;4(5):769-81.
2002: Charles M Samson; Laura W Schrum; Mark A Bird; Patricia A Lange; David A Brenner; Richard A Rippe; Kevin E Behrns
Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism.
Surgery 2002;132(3):441-9.
2002: David A Brenner; Michael Camilleri
Joint statement on missions and submissions of papers to AGA journals.
Gastroenterology 2002;123(3):877-8.
2002: Scott T Magness; Nobuyo Maeda; David A Brenner
An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria.
Blood 2002;100(4):1470-7.
2002: Christian Liedtke; Jörg Plümpe; Stefan Kubicka; Cynthia A Bradham; Michael P Manns; David A Brenner; Christian Trautwein
Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells.
Hepatology (Baltimore, Md.) 2002;36(2):315-25.
2002: Robert F Schwabe; David A Brenner
Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(1):G204-11.
2002: Maria P Russo; Brydon L Bennett; Anthony Manning; David A Brenner; Christian Jobin
Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas.
American journal of physiology. Cell physiology 2002;283(1):C347-57.
2002: Branko Stefanovic; Bernd Schnabl; David A Brenner
Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy.
The Journal of biological chemistry 2002;277(20):18229-37.
2002: Bernd Schnabl; Youkyung Hwang Choi; John C Olsen; Curt H Hagedorn; David A Brenner
Immortal activated human hepatic stellate cells generated by ectopic telomerase expression.
Laboratory investigation; a journal of technical methods and pathology 2002;82(3):323-33.
2001: Y O Kweon; Zachary D Goodman; Jules L Dienstag; Eugene R Schiff; N A Brown; E Burchardt; Robert Schoonhoven; David A Brenner; Michael W Fried; E Burkhardt
Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B.
Journal of hepatology 2001;35(6):749-55.
2001: Etsuro Hatano; David A Brenner
Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(6):G1357-68.
2001: Bernd Schnabl; Cynthia A Bradham; Brydon L Bennett; Anthony Manning; Branko Stefanovic; David A Brenner
TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells.
Hepatology (Baltimore, Md.) 2001;34(5):953-63.
2001: Cynthia A Bradham; Etsuro Hatano; David A Brenner
Dominant-negative TAK1 induces c-Myc and G(0) exit in liver.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(5):G1279-89.
2001: N Enomoto; Peter Schemmer; Kenichi Ikejima; Yoshiyuki Takei; Nobuhiro Sato; David A Brenner; Ronald G Thurman
Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide.
Alcoholism, clinical and experimental research 2001;25(9):1360-7.
2001: R Bataller; David A Brenner
Hepatic stellate cells as a target for the treatment of liver fibrosis.
Seminars in liver disease 2001;21(3):437-51.
2001: Bernd Schnabl; Young Oh Kweon; J P Frederick; X F Wang; Richard A Rippe; David A Brenner
The role of Smad3 in mediating mouse hepatic stellate cell activation.
Hepatology (Baltimore, Md.) 2001;34(1):89-100.
2001: Yosuke Osawa; Yoshiko Banno; Masahito Nagaki; David A Brenner; Takafumi Naiki; Yoshinori Nozawa; Shigeru Nakashima; Hisataka Moriwaki
TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):173-80.
2001: Robert F Schwabe; Bernd Schnabl; Young Oh Kweon; David A Brenner
CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(11):6812-9.
2001: Hiroshi Kono; M Nakagami; Ivan Rusyn; Henry D Connor; Branko Stefanovic; David A Brenner; Ronald P Mason; Gavin E Arteel; Ronald G Thurman
Development of an animal model of chronic alcohol-induced pancreatitis in the rat.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(6):G1178-86.
2001: Manuela G Neuman; David A Brenner; B Rehermann; J Taieb; Sylvie Chollet-Martin; M Cohard; JJ Garaud; T Poynard; Gady G Katz; Ross G Cameron; Neil H Shear; B Gao; Masashi Takamatsu; Masayoshi Yamauchi; Mitsuru Ohata; Saburo Saito; Shiro Maeyama; Toshiyuki Uchikoshi; Gotaro Toda; Teru Kumagi; Sk Md Fazle Akbar; M Abe; Kojiro Michitaka; Norio Horiike; Morikazu Onji
Mechanisms of alcoholic liver disease: cytokines.
Alcoholism, clinical and experimental research 2001;25(5 Suppl ISBRA):251S-253S.
2001: Etsuro Hatano; Brydon L Bennett; Anthony Manning; Ting Qian; John J Lemasters; David A Brenner
NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis.
Gastroenterology 2001;120(5):1251-62.
2001: Richard A Rippe; David A Brenner; A Tugores
Techniques to measure nucleic acid-protein binding and specificity. Nuclear extract preparations, DNase I footprinting, and mobility shift assays.
Methods in molecular biology (Clifton, N.J.) 2001;160():459-79.
2001: Robert F Schwabe; Brydon L Bennett; Anthony Manning; David A Brenner
Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes.
Hepatology (Baltimore, Md.) 2001;33(1):81-90.
2001: Laura W Schrum; Mark A Bird; O Salcher; ER Burchardt; Joe W Grisham; David A Brenner; Richard A Rippe; Kevin E Behrns
Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(1):G139-48.
2000: A Lang; Laura W Schrum; Robert Schoonhoven; S Tuvia; José A Solís-Herruzo; H Tsukamoto; David A Brenner; Richard A Rippe
Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(6):G1333-42.
2000: Masahito Nagaki; Takafumi Naiki; David A Brenner; Yosuke Osawa; Motoaki Imose; Hideki Hayashi; Yoshiko Banno; Shigeru Nakashima; Hisataka Moriwaki
Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB.
Hepatology (Baltimore, Md.) 2000;32(6):1272-9.
2000: Thorsten G Lehmann; Michael D Wheeler; Robert F Schwabe; Henry D Connor; Robert Schoonhoven; Hartwig Bunzendahl; David A Brenner; R Jude Samulski; Zhi Zhong; Ronald G Thurman
Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat.
Hepatology (Baltimore, Md.) 2000;32(6):1255-64.
2000: Jeffrey N Lindquist; SG Kauschke; Branko Stefanovic; ER Burchardt; David A Brenner
Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA.
Nucleic acids research 2000;28(21):4306-16.
2000: David A Brenner
Moderate alcohol drinking: effects on the heart and liver.
Gastroenterology 2000;119(5):1399-401.
2000: Li-Hui Xu; X Yang; C A Bradham; David A Brenner; Albert S Baldwin; Rolf J Craven; William G Cance
The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways.
The Journal of biological chemistry 2000;275(39):30597-604.
2000: Konrad L Streetz; Ludger Leifeld; D Grundmann; Jan Ramakers; K Eckert; Ulrich Spengler; David A Brenner; Michael P Manns; Christian Trautwein
Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure.
Gastroenterology 2000;119(2):446-60.
2000: A Lang; Robert Schoonhoven; S Tuvia; David A Brenner; Richard A Rippe
Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells.
Journal of hepatology 2000;33(1):49-58.
2000: N Enomoto; Kenichi Ikejima; S Yamashina; A Enomoto; T Nishiura; T Nishimura; David A Brenner; Peter Schemmer; Blair U Bradford; CA Rivera; Zhi Zhong; Ronald G Thurman
Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(1):G100-6.
2000: Scott T Magness; A Tugores; David A Brenner
Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells.
Blood 2000;95(11):3568-77.
2000: Ulrich Böcker; Arndt Schottelius; Joanna M Watson; L Holt; LL Licato; David A Brenner; Ryan Sartor; Christian Jobin
Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells.
The Journal of biological chemistry 2000;275(16):12207-13.
2000: Etsuro Hatano; Cynthia A Bradham; A Stark; Yuji Iimuro; John J Lemasters; David A Brenner
The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes.
The Journal of biological chemistry 2000;275(16):11814-23.
2000: N Enomoto; Kenichi Ikejima; Blair U Bradford; CA Rivera; Hiroshi Kono; M Goto; S Yamashina; Peter Schemmer; Tsuneo Kitamura; H Oide; Yoshiyuki Takei; Miyoko Hirose; H Shimizu; Akihisa Miyazaki; David A Brenner; Nobuhiro Sato; Ronald G Thurman
Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury.
Journal of gastroenterology and hepatology 2000;15 Suppl():D20-5.
2000: T Nishiura; Tetsuro Nishimura; Suzan DeSerres; Virginia L Godfrey; C A Bradham; T Nakagawa; David A Brenner; Anthony A Meyer
Gene expression and cytokine and enzyme activation in the liver after a burn injury.
The Journal of burn care & rehabilitation 2000;21(2):135-41.
2000: Yuji Iimuro; Blair U Bradford; S Yamashina; Ivan Rusyn; M Nakagami; N Enomoto; Hiroshi Kono; W Frey; Donald Forman; David A Brenner; Ronald G Thurman
The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat.
Hepatology (Baltimore, Md.) 2000;31(2):391-8.
2000: Laura W Schrum; Dalliah Black; Yuji Iimuro; Richard A Rippe; David A Brenner; Kevin E Behrns
c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy.
The Journal of surgical research 2000;88(2):142-9.
2000: Branko Stefanovic; Jeffrey N Lindquist; David A Brenner
The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix.
Nucleic acids research 2000;28(2):641-7.
2000: Jeffrey N Lindquist; Branko Stefanovic; David A Brenner
Regulation of collagen alpha1(I) expression in hepatic stellate cells.
Journal of gastroenterology 2000;35 Suppl 12():80-3.
2000: David A Brenner; T Waterboer; S K Choi; Jeffrey N Lindquist; Branko Stefanovic; ER Burchardt; Mitsuo Yamauchi; Andrea Gillan; Richard A Rippe
New aspects of hepatic fibrosis.
Journal of hepatology 2000;32(1 Suppl):32-8.
2000: Tetsuro Nishimura; T Nishiura; Suzan DeSerres; T Nakagawa; David A Brenner; Anthony A Meyer
Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels.
The Journal of trauma 2000;48(1):39-44.
2000: Jon Rhoads; Robert A Argenzio; W Chen; Lee M Graves; L L Licato; Anthony T Blikslager; J Smith; John Gatzy Jr; David A Brenner
Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism.
Gastroenterology 2000;118(1):90-100.
1999: Ivan Rusyn; Cynthia A Bradham; L Cohn; Robert Schoonhoven; James A Swenberg; David A Brenner; Ronald G Thurman
Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms.
Carcinogenesis 1999;20(11):2095-100.
1999: José A Solís-Herruzo; Richard A Rippe; Laura W Schrum; Paz de la Torre; I García; J J Jeffrey; Teresa Muñoz-Yagüe; David A Brenner
Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts.
The Journal of biological chemistry 1999;274(43):30919-26.
1999: Richard A Rippe; Laura W Schrum; Branko Stefanovic; José A Solís-Herruzo; David A Brenner
NF-kappaB inhibits expression of the alpha1(I) collagen gene.
DNA and cell biology 1999;18(10):751-61.
1999: Christian Jobin; Cynthia A Bradham; Maria P Russo; B Juma; A S Narula; David A Brenner; Ryan Sartor
Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3474-83.
1999: N Enomoto; S Yamashina; Peter Schemmer; CA Rivera; Blair U Bradford; A Enomoto; David A Brenner; Ronald G Thurman
Estriol sensitizes rat Kupffer cells via gut-derived endotoxin.
The American journal of physiology 1999;277(3 Pt 1):G671-7.
1999: John J Lemasters; Ting Qian; Cynthia A Bradham; David A Brenner; Wayne E Cascio; LC Trost; Yoshiya Nishimura; Anna-Liisa Nieminen; Brian Herman
Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death.
Journal of bioenergetics and biomembranes 1999;31(4):305-19.
1999: Katsuhiro Uzawa; Wojciech J Grzesik; T Nishiura; Sergei A Kuznetsov; Pamela Robey; David A Brenner; Mitsuo Yamauchi
Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(8):1272-80.
1999: R K Batra; Denis C Guttridge; David A Brenner; S M Dubinett; Albert S Baldwin; Richard C Boucher
IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death.
American journal of respiratory cell and molecular biology 1999;21(2):238-45.
1999: Cynthia A Bradham; Peter Schemmer; Robert Stachlewitz; Ronald G Thurman; David A Brenner
Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells.
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 1999;5(4):282-93.
1999: N Enomoto; S Yamashina; Hiroshi Kono; Peter Schemmer; CA Rivera; A Enomoto; T Nishiura; T Nishimura; David A Brenner; Ronald G Thurman
Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells.
Hepatology (Baltimore, Md.) 1999;29(6):1680-9.
1999: Branko Stefanovic; Claus Hellerbrand; David A Brenner
Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA.
Molecular and cellular biology 1999;19(6):4334-42.
1999: Christian Jobin; L Holt; Cynthia A Bradham; K Streetz; David A Brenner; Ryan Sartor
TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4447-54.
1999: Christian Jobin; Kevin E Behrns; David A Brenner
Molecular and cellular biology of the small intestine.
Current opinion in gastroenterology 1999;15(2):103-7.
1999: A Lang; David A Brenner
Gene regulation in hepatic stellate cell.
Italian journal of gastroenterology and hepatology 1999;31(2):173-9.
1999: Kenichi Ikejima; N Enomoto; VITOR SEABRA; A Ikejima; David A Brenner; Ronald G Thurman
Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells.
The American journal of physiology 1999;276(3 Pt 1):G591-8.
1999: Scott T Magness; David A Brenner
Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion.
Biochimica et biophysica acta 1999;1453(1):161-74.
1999: John J Lemasters; Ting Qian; LC Trost; Brian Herman; Wayne E Cascio; Cynthia A Bradham; David A Brenner; Anna-Liisa Nieminen
Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death.
Biochemical Society symposium 1999;66():205-22.
1999: K Krempen; D Grotkopp; K Hall; A Bache; Andrea Gillan; Richard A Rippe; David A Brenner; Michael Breindl
Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice.
Gene expression 1999;8(3):151-63.
1999: Claus Hellerbrand; Branko Stefanovic; F Giordano; ER Burchardt; David A Brenner
The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo.
Journal of hepatology 1999;30(1):77-87.
1998: Cynthia A Bradham; Ting Qian; K Streetz; Christian Trautwein; David A Brenner; John J Lemasters
The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release.
Molecular and cellular biology 1998;18(11):6353-64.
1998: Yolanda Scarlett; David A Brenner
Porphyrias.
Journal of clinical gastroenterology 1998;27(3):192-8.
1998: Y Xu; S Bialik; Brett E Jones; Y Iimuro; Richard N Kitsis; A Srinivasan; David A Brenner; Mark J Czaja
NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis.
The American journal of physiology 1998;275(4 Pt 1):C1058-66.
1998: David A Brenner
Signal transduction during liver regeneration.
Journal of gastroenterology and hepatology 1998;13 Suppl():S93-5.
1998: Ronald G Thurman; Blair U Bradford; Yuji Iimuro; KT Knecht; Gavin E Arteel; M Yin; Henry D Connor; C Wall; James Raleigh; MV Frankenberg; Y Adachi; Donald Forman; David A Brenner; Maria B Kadiiska; Ronald P Mason
The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury.
Journal of gastroenterology and hepatology 1998;13 Suppl():S39-50.
1998: Cynthia A Bradham; Jörg Plümpe; Michael P Manns; David A Brenner; Christian Trautwein
Mechanisms of hepatic toxicity. I. TNF-induced liver injury.
The American journal of physiology 1998;275(3 Pt 1):G387-92.
1998: John J Lemasters; Anna-Liisa Nieminen; Ting Qian; LC Trost; Steven P Elmore; Yoshiya Nishimura; R A Crowe; Wayne E Cascio; Cynthia A Bradham; David A Brenner; Brian Herman
The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.
Biochimica et biophysica acta 1998;1366(1-2):177-96.
1998: Claus Hellerbrand; Christian Jobin; LL Licato; Ryan Sartor; David A Brenner
Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells.
The American journal of physiology 1998;275(2 Pt 1):G269-78.
1998: N Enomoto; Kenichi Ikejima; Blair U Bradford; C Rivera; Hiroshi Kono; David A Brenner; Ronald G Thurman
Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin.
Gastroenterology 1998;115(2):443-51.
1998: LL Licato; David A Brenner
Analysis of signaling protein kinases in human colon or colorectal carcinomas.
Digestive diseases and sciences 1998;43(7):1454-64.
1998: Joseph R Bloomer; C Bruzzone; L Zhu; Yolanda Scarlett; Scott T Magness; David A Brenner
Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation.
The Journal of clinical investigation 1998;102(1):107-14.
1998: Scott T Magness; A Tugores; E S Diala; David A Brenner
Analysis of the human ferrochelatase promoter in transgenic mice.
Blood 1998;92(1):320-8.
1998: Christian Jobin; Claus Hellerbrand; LL Licato; David A Brenner; Ryan Sartor
Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors.
Gut 1998;42(6):779-87.
1998: Claus Hellerbrand; Christian Jobin; Yuji Iimuro; LL Licato; Ryan Sartor; David A Brenner
Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor.
Hepatology (Baltimore, Md.) 1998;27(5):1285-95.
1998: Christian Trautwein; T Rakemann; David A Brenner; Konrad L Streetz; L Licato; Michael P Manns; Gisa Tiegs
Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice.
Gastroenterology 1998;114(5):1035-45.
1998: Kenichi Ikejima; N Enomoto; Yuji Iimuro; A Ikejima; D Fang; J Xu; Donald Forman; David A Brenner; Ronald G Thurman
Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin.
The American journal of physiology 1998;274(4 Pt 1):G669-76.
1998: Yuji Iimuro; T Nishiura; Claus Hellerbrand; Kevin E Behrns; Robert Schoonhoven; Joe W Grisham; David A Brenner
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.
The Journal of clinical investigation 1998;101(4):802-11.
1998: Yolanda Scarlett; David A Brenner; J R Bloomer
Hepatic porphyrias.
Clinics in liver disease 1998;2(1):77-102, vi.
1998: John J Lemasters; Ting Qian; Steven P Elmore; LC Trost; Yoshiya Nishimura; Brian Herman; Cynthia A Bradham; David A Brenner; Anna-Liisa Nieminen
Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy.
BioFactors (Oxford, England) 1998;8(3-4):283-5.
1998: Christian Jobin; Asit Panja; Claus Hellerbrand; Yuji Iimuro; J Didonato; David A Brenner; Ryan Sartor
Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):410-8.
1997: LL Licato; Temitope Keku; J I Wurzelmann; SC Murray; John T Woosley; Robert S Sandler; David A Brenner
In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia.
Gastroenterology 1997;113(5):1589-98.
1997: Y Xu; C Bradham; David A Brenner; Mark J Czaja
Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation.
The American journal of physiology 1997;273(4 Pt 1):G795-803.
1997: Branko Stefanovic; Claus Hellerbrand; Martin Holcik; M Briendl; S Aliebhaber; David A Brenner
Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells.
Molecular and cellular biology 1997;17(9):5201-9.
1997: Jon Rhoads; Robert A Argenzio; W Chen; Richard A Rippe; J K Westwick; Adrienne D Cox; H M Berschneider; David A Brenner
L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases.
The American journal of physiology 1997;272(5 Pt 1):G943-53.
1997: Cynthia A Bradham; Robert Stachlewitz; W Gao; Ting Qian; Supriya Jayadev; G Jenkins; Yusuf A Hannun; John J Lemasters; Ronald G Thurman; David A Brenner
Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases.
Hepatology (Baltimore, Md.) 1997;25(5):1128-35.
1997: Richard A Rippe; A Umezawa; J P Kimball; Michael Breindl; David A Brenner
Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription.
The Journal of biological chemistry 1997;272(3):1753-60.
1996: Ariane Mallat; Anne-Marie Préaux; Claudine Serradeil-Le Gal; Danielle Raufaste; C Gallois; David A Brenner; C Bradham; Jacques Maclouf; V Iourgenko; L Fouassier; Daniel Dhumeaux; Philippe Mavier; Sophie Lotersztajn
Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors.
The Journal of clinical investigation 1996;98(12):2771-8.
1996: JK Westwick; J Fleckenstein; M Yin; Shi Qi Yang; C A Bradham; David A Brenner; Anna Mae Diehl
Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo.
The American journal of physiology 1996;271(5 Pt 1):G780-90.
1996: Yuji Iimuro; Blair U Bradford; W Gao; Maria B Kadiiska; Ronald P Mason; Branko Stefanovic; David A Brenner; Ronald G Thurman
Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat.
Molecular pharmacology 1996;50(3):656-61.
1996: S C Wang; H Tsukamoto; David A Brenner; Richard A Rippe
Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells.
Hepatology (Baltimore, Md.) 1996;24(3):670-6.
1996: David A Brenner
New functions for the aryl hydrocarbon receptor.
Hepatology (Baltimore, Md.) 1996;23(2):379-80.
1995: Scott T Magness; David A Brenner
Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells.
Human gene therapy 1995;6(10):1285-90.
1995: H M Kandil; Robert A Argenzio; W Chen; H M Berschneider; Alan D Stiles; JK Westwick; Richard A Rippe; David A Brenner; Jon Rhoads
L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line.
The American journal of physiology 1995;269(4 Pt 1):G591-9.
1995: JK Westwick; Alicja Bielawska; Ghassan Dbaibo; Yusuf A Hannun; David A Brenner
Ceramide activates the stress-activated protein kinases.
The Journal of biological chemistry 1995;270(39):22689-92.
1995: J G Simmons; E C Hoyt; J K Westwick; David A Brenner; J B Pucilowska; P Kay Lund
Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells.
Molecular endocrinology (Baltimore, Md.) 1995;9(9):1157-65.
1995: Richard A Rippe; G Almounajed; David A Brenner
Sp1 binding activity increases in activated Ito cells.
Hepatology (Baltimore, Md.) 1995;22(1):241-51.
1995: James F Trotter; David A Brenner
Current and prospective therapies for hepatic fibrosis.
Comprehensive therapy 1995;21(6):303-7.
1995: JK Westwick; C Weitzel; Hyam L Leffert; David A Brenner
Activation of Jun kinase is an early event in hepatic regeneration.
The Journal of clinical investigation 1995;95(2):803-10.
1995: Branko Stefanovic; Claus Hellerbrand; David A Brenner
Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells.
Nucleic acids symposium series 1995;(33):212-4.
1995: JK Westwick; David A Brenner
Methods for analyzing c-Jun kinase.
Methods in enzymology 1995;255():342-59.
1994: A Tugores; Scott T Magness; David A Brenner
A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene.
The Journal of biological chemistry 1994;269(49):30789-97.
1994: David A Brenner; Richard A Rippe; K Rhodes; J F Trotter; Michael Breindl
Fibrogenesis and type I collagen gene regulation.
The Journal of laboratory and clinical medicine 1994;124(6):755-60.
1994: JK Westwick; C Weitzel; Audrey Minden; Michael Karin; David A Brenner
Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase.
The Journal of biological chemistry 1994;269(42):26396-401.
1994: Anna Mae Diehl; M Yin; J Fleckenstein; Shi Qi Yang; HZ Lin; David A Brenner; JK Westwick; G Bagby; S Nelson
Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury.
The American journal of physiology 1994;267(4 Pt 1):G552-61.
1994: K Rhodes; Richard A Rippe; Akihiro Umezawa; M Nehls; David A Brenner; Michael Breindl
DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism.
Molecular and cellular biology 1994;14(9):5950-60.
1994: Scott T Magness; A Tugores; S R Christensen; C Wagner-Mcpherson; G A Evans; E W Naylor; David A Brenner
Deletion of the ferrochelatase gene in a patient with protoporphyria.
Human molecular genetics 1994;3(9):1695-7.
1994: A Tugores; David A Brenner
A method for in vitro DNase I footprinting analysis on supercoiled templates.
BioTechniques 1994;17(3):410-2.
1994: Adrienne D Cox; AM Garcia; JK Westwick; J J Kowalczyk; MD Lewis; David A Brenner; Channing J Der
The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation.
The Journal of biological chemistry 1994;269(30):19203-6.
1994: JK Westwick; Adrienne D Cox; Channing J Der; M H Cobb; Masahiko Hibi; Michael Karin; David A Brenner
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6030-4.
1993: M C Nehls; David A Brenner; H J Gruss; H Dierbach; R Mertelsmann; F Herrmann
Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast.
The Journal of clinical investigation 1993;92(6):2916-21.
1993: kenneth roebuck; David A Brenner; Martin F Kagnoff
Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1.
The Journal of clinical investigation 1993;92(3):1336-48.
1993: Katherine S Koch; R G Fletcher; M P Grond; A I Inyang; X P Lu; David A Brenner; Hyam L Leffert
Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes.
Cancer research 1993;53(10 Suppl):2279-86.
1993: David A Brenner; J Westwick; M Breindl
Type I collagen gene regulation and the molecular pathogenesis of cirrhosis.
The American journal of physiology 1993;264(4 Pt 1):G589-95.
1993: David A Brenner; L Veloz; Rudolf Jaenisch; J M Alcorn
Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis.
Hepatology (Baltimore, Md.) 1993;17(2):287-92.
1993: M Hattori; A Tugores; J K Westwick; L Veloz; Hyam L Leffert; Michael Karin; David A Brenner
Activation of activating protein 1 during hepatic acute phase response.
The American journal of physiology 1993;264(1 Pt 1):G95-103.
1993: David A Brenner
Transforming growth factor-beta 1: there is regulation beyond transcription.
Hepatology (Baltimore, Md.) 1993;17(1):164-6.
1992: A Lin; Jeffrey A Frost; T Deng; T Smeal; N al-Alawi; U Kikkawa; Tony Hunter; David A Brenner; Michael Karin
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.
Cell 1992;70(5):777-89.
1992: M C Nehls; M L Grapilon; David A Brenner
NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression.
DNA and cell biology 1992;11(6):443-52.
1992: David A Brenner; J M Didier; F Frasier; S R Christensen; G A Evans; Harry A. Dailey
A molecular defect in human protoporphyria.
American journal of human genetics 1992;50(6):1203-10.
1992: Katherine S Koch; X P Lu; David A Brenner; Hyam L Leffert
Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture.
Biochemical and biophysical research communications 1992;183(1):184-92.
1991: K Houglum; David A Brenner; M Chojkier
Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation.
The American journal of clinical nutrition 1991;54(6 Suppl):1141S-1143S.
1991: David A Brenner
Transforming growth factor B and hepatic fibrosis: cause or effect?
Hepatology (Baltimore, Md.) 1991;14(4 Pt 1):740-2.
1991: M C Nehls; Richard A Rippe; L Veloz; David A Brenner
Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter.
Molecular and cellular biology 1991;11(8):4065-73.
1991: K Houglum; David A Brenner; M Chojkier
d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation.
The Journal of clinical investigation 1991;87(6):2230-5.
1991: M Bishr Omary; David A Brenner; L Y de Grandpre; kenneth roebuck; Douglas D Richman; Martin F Kagnoff
HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines.
AIDS (London, England) 1991;5(3):275-81.
1991: David A Brenner; F Frasier
Cloning of murine ferrochelatase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):849-53.
1991: Martin F Kagnoff; M Bishr Omary; L Y de Grandpre; kenneth roebuck; Douglas D Richman; David A Brenner
Expression of human immunodeficiency virus-1 in human colonic cells.
Immunologic research 1991;10(3-4):452-5.
1990: M Hattori; A Tugores; L Veloz; Michael Karin; David A Brenner
A simplified method for the preparation of transcriptionally active liver nuclear extracts.
DNA and cell biology 1990;9(10):777-81.
1990: Katherine S Koch; X P Lu; David A Brenner; G H Fey; A Martinez-Conde; Hyam L Leffert
Mitogens and hepatocyte growth control in vivo and in vitro.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1990;26(11):1011-23.
1990: J A Alcorn; S P Feitelberg; David A Brenner
Transient induction of c-jun during hepatic regeneration.
Hepatology (Baltimore, Md.) 1990;11(6):909-15.
1990: David A Brenner; J M Alcorn; S P Feitelberg; Hyam L Leffert; M Chojkier
Expression of collagen genes in the liver.
Molecular biology & medicine 1990;7(2):105-15.
1990: David A Brenner; J M Alcorn
Therapy for hepatic fibrosis.
Seminars in liver disease 1990;10(1):75-83.
1990: Richard A Rippe; David A Brenner; Hyam L Leffert
DNA-mediated gene transfer into adult rat hepatocytes in primary culture.
Molecular and cellular biology 1990;10(2):689-95.
1990: David A Brenner; M Buck; S P Feitelberg; M Chojkier
Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia.
The Journal of clinical investigation 1990;85(1):248-55.
1990: Hyam L Leffert; Katherine S Koch; X P Lu; David A Brenner; Michael Karin; H F Skelly; Richard A Rippe; G Fey; M Chojkier
Cellular and molecular biology of hepatocyte growth, regeneration and gene expression.
Advances in second messenger and phosphoprotein research 1990;24():352-8.
1989: M Chojkier; K Houglum; J Solis-Herruzo; David A Brenner
Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation?
The Journal of biological chemistry 1989;264(28):16957-62.
1989: B A Volk; David A Brenner; Martin F Kagnoff
Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies.
Gut 1989;30(9):1220-4.
1989: David A Brenner; Richard A Rippe; L Veloz
Analysis of the collagen alpha 1(I) promoter.
Nucleic acids research 1989;17(15):6055-64.
1989: M Chojkier; David A Brenner; Hyam L Leffert
Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes.
The Journal of biological chemistry 1989;264(16):9583-91.
1989: Richard A Rippe; S I Lorenzen; David A Brenner; Michael Breindl
Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene.
Molecular and cellular biology 1989;9(5):2224-7.
1989: David A Brenner; Katherine S Koch; Hyam L Leffert
Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes.
DNA (Mary Ann Liebert, Inc.) 1989;8(4):279-85.
1989: David A Brenner; M O'Hara; P Angel; M Chojkier; Michael Karin
Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha.
Nature 1989;337(6208):661-3.
1988: M Chojkier; M Flaherty; B Peterkofsky; G H Majmudar; R G Spanheimer; David A Brenner
Different mechanisms decrease hepatic collagen and albumin production in fasted rats.
Hepatology (Baltimore, Md.) 1988;8(5):1040-5.
1988: J A Solis-Herruzo; David A Brenner; M Chojkier
Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts.
The Journal of biological chemistry 1988;263(12):5841-5.
1988: M Chojkier; David A Brenner
Therapeutic strategies for hepatic fibrosis.
Hepatology (Baltimore, Md.) 1988;8(1):176-82.
1987: David A Brenner; M Chojkier
Acetaldehyde increases collagen gene transcription in cultured human fibroblasts.
The Journal of biological chemistry 1987;262(36):17690-5.
1980: David A Brenner; J R Bloomer
The enzymatic defect in variegate prophyria. Studies with human cultured skin fibroblasts.
The New England journal of medicine 1980;302(14):765-9.
1980: David A Brenner; J R Bloomer
A fluorometric assay for measurement of protoporphyrinogen oxidase activity in mammalian tissue.
Clinica chimica acta; international journal of clinical chemistry 1980;100(3):259-66.
1979: David A Brenner; J R Bloomer
Comparison of human and bovine protoporphyria.
The Yale journal of biology and medicine 1979;52(5):449-54.
1977: J R Bloomer; David A Brenner; M J Mahoney
Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria.
The Journal of clinical investigation 1977;60(6):1354-61.
1977: David A Brenner; J R Bloomer
Heme content of normal and porphyric cultured skin fibroblasts.
Biochemical genetics 1977;15(11-12):1061-70.