David Brenner

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Anatomy

Living Beings

Chemicals & Drugs

Disorders

Liver Cirrhosis

Physiology

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Publications

TOP 3
Kodama Yuzo; Kisseleva Tatiana; Iwaisako Keiko; Miura Kouichi; Taura Kojiro; De Minicis Samuele; Osterreicher Christoph H; Schnabl Bernd; Seki Ekihiro; Brenner David A
c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice.
Osterreicher Christoph H; Taura Kojiro; De Minicis Samuele; Seki Ekihiro; Penz-Osterreicher Melitta; Kodama Yuzo; Kluwe Johannes; Schuster Manfred; Oudit Gavin Y; Penninger Josef M; Brenner David A
Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice.
Seki Ekihiro; De Minicis Samuele; Gwak Geum-Youn; Kluwe Johannes; Inokuchi Sayaka; Bursill Christina A; Llovet Josep M; Brenner David A; Schwabe Robert F
CCR1 and CCR5 promote hepatic fibrosis in mice.

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All Publications

2009: Kodama Yuzo; Kisseleva Tatiana; Iwaisako Keiko; Miura Kouichi; Taura Kojiro; De Minicis Samuele; Osterreicher Christoph H; Schnabl Bernd; Seki Ekihiro; Brenner David A
c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice.
Gastroenterology 2009;137(4):1467-1477.e5.
2009: Osterreicher Christoph H; Taura Kojiro; De Minicis Samuele; Seki Ekihiro; Penz-Osterreicher Melitta; Kodama Yuzo; Kluwe Johannes; Schuster Manfred; Oudit Gavin Y; Penninger Josef M; Brenner David A
Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice.
Hepatology (Baltimore, Md.) 2009;50(3):929-38.
2009: Seki Ekihiro; De Minicis Samuele; Gwak Geum-Youn; Kluwe Johannes; Inokuchi Sayaka; Bursill Christina A; Llovet Josep M; Brenner David A; Schwabe Robert F
CCR1 and CCR5 promote hepatic fibrosis in mice.
The Journal of clinical investigation 2009;119(7):1858-70.
2009: Seki Ekihiro; de Minicis Samuele; Inokuchi Sayaka; Taura Kojiro; Miyai Katsumi; van Rooijen Nico; Schwabe Robert F; Brenner David A
CCR2 promotes hepatic fibrosis in mice.
Hepatology (Baltimore, Md.) 2009;50(1):185-97.
2009: Kodama Yuzo; Taura Kojiro; Miura Kouichi; Schnabl Bernd; Osawa Yosuke; Brenner David A
Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis.
Gastroenterology 2009;136(4):1423-34.
2009: Gäbele Erwin; Froh Matthias; Arteel Gavin E; Uesugi Takehiko; Hellerbrand Claus; Schölmerich Jürgen; Brenner David A; Thurman Ronald G; Rippe Richard A
TNFalpha is required for cholestasis-induced liver fibrosis in the mouse.
Biochemical and biophysical research communications 2009;378(3):348-53.
2008: De Minicis Samuele; Seki Ekihiro; Oesterreicher Christoph; Schnabl Bernd; Schwabe Robert F; Brenner David A
Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells.
Hepatology (Baltimore, Md.) 2008;48(6):2016-26.
2008: Taura Kojiro; De Minicis Samuele; Seki Ekihiro; Hatano Etsuro; Iwaisako Keiko; Osterreicher Christoph H; Kodama Yuzo; Miura Kouichi; Ikai Iwao; Uemoto Shinji; Brenner David A
Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis.
Gastroenterology 2008;135(5):1729-38.
2008: Miura Kouichi; Taura Kojiro; Kodama Yuzo; Schnabl Bernd; Brenner David A
Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity.
Hepatology (Baltimore, Md.) 2008;48(5):1420-9.
2008: Schnabl Bernd; Scholten David; Brenner David A
What is the potential role of antifibrotic agents for the treatment of liver disease?
Nature clinical practice. Gastroenterology & hepatology 2008;5(9):496-7.
2008: Seki Ekihiro; Brenner David A
Toll-like receptors and adaptor molecules in liver disease: update.
Hepatology (Baltimore, Md.) 2008;48(1):322-35.
2008: Kisseleva Tatiana; Brenner David A
Fibrogenesis of parenchymal organs.
Proceedings of the American Thoracic Society 2008;5(3):338-42.
2008: De Minicis Samuele; Brenner David A
Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex.
Journal of gastroenterology and hepatology 2008;23 Suppl 1():S98-103.
2008: Kisseleva Tatiana; Brenner David A
Mechanisms of fibrogenesis.
Experimental biology and medicine (Maywood, N.J.) 2008;233(2):109-22.
2008: Adachi Masayuki; Brenner David A
High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase.
Hepatology (Baltimore, Md.) 2008;47(2):677-85.
2007: Tacke Frank; Gäbele Erwin; Bataille Frauke; Schwabe Robert F; Hellerbrand Claus; Klebl Frank; Straub Rainer H; Luedde Tom; Manns Michael P; Trautwein Christian; Brenner David A; Schölmerich Jürgen; Schnabl Bernd
Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells.
Digestive diseases and sciences 2007;52(12):3404-15.
2007: Seki Ekihiro; De Minicis Samuele; Osterreicher Christoph H; Kluwe Johannes; Osawa Yosuke; Brenner David A; Schwabe Robert F
TLR4 enhances TGF-beta signaling and hepatic fibrosis.
Nature medicine 2007;13(11):1324-32.
2007: Mencin Ali; Seki Ekihiro; Osawa Yosuke; Kodama Yuzo; De Minicis Samuele; Knowles Michael; Brenner David A
Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis.
Hepatology (Baltimore, Md.) 2007;46(5):1443-52.
2007: Tacke Frank; Trautwein Christian; Yagmur Eray; Hellerbrand Claus; Wiest Reiner; Brenner David A; Schnabl Bernd
Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course.
Journal of gastroenterology and hepatology 2007;22(8):1256-64.
2007: Seki Ekihiro; Brenner David A
The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor?
Journal of hepatology 2007;47(2):307-9.
2007: Kisseleva Tatiana; Brenner David A
Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis.
Journal of gastroenterology and hepatology 2007;22 Suppl 1():S73-8.
2007: De Minicis Samuele; Brenner David A
NOX in liver fibrosis.
Archives of biochemistry and biophysics 2007;462(2):266-72.
2007: De Minicis Samuele; Seki Ekihiro; Uchinami Hiroshi; Kluwe Johannes; Zhang Yonghui; Brenner David A; Schwabe Robert F
Gene expression profiles during hepatic stellate cell activation in culture and in vivo.
Gastroenterology 2007;132(5):1937-46.
2007: Osterreicher Christoph H; Brenner David A
The genetics of nonalcoholic fatty liver disease.
Annals of hepatology : official journal of the Mexican Association of Hepatology 2007;6(2):83-8.
2007: Adachi Masayuki; Osawa Yosuke; Uchinami Hiroshi; Kitamura Tadahiro; Accili Domenico; Brenner David A
The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells.
Gastroenterology 2007;132(4):1434-46.
2007: Osterreicher Christoph H; Stickel Felix; Brenner David A
Genomics of liver fibrosis and cirrhosis.
Seminars in liver disease 2007;27(1):28-43.
2006: Osawa Yosuke; Seki Ekihiro; Adachi Masayuki; Taura Kojiro; Kodama Yuzo; Siegmund Soren V; Schwabe Robert F; Brenner David A
Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(9):1138-47.
2006: Kisseleva Tatiana; Brenner David A
Hepatic stellate cells and the reversal of fibrosis.
Journal of gastroenterology and hepatology 2006;21 Suppl 3():S84-7.
2006: Kisseleva Tatiana; Uchinami Hiroshi; Feirt Nikki; Quintana-Bustamante Oscar; Segovia Jose Carlos; Schwabe Robert F; Brenner David A
Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis.
Journal of hepatology 2006;45(3):429-38.
2006: Lehnert Mark; Uehara Tetsuya; Bradford Blair U; Lind Henrik; Zhong Zhi; Brenner David A; Marzi Ingo; Lemasters John J
Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(3):G456-63.
2006: Uchinami Hiroshi; Seki Ekihiro; Brenner David A; D'Armiento Jeanine
Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis.
Hepatology (Baltimore, Md.) 2006;44(2):420-9.
2006: Zhong Zhi; Schwabe Robert F; Kai Yoichiro; He Lihua; Yang Liu; Bunzendahl Hartwig; Brenner David A; Lemasters John J
Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply.
Transplantation 2006;82(2):241-50.
2006: De Minicis Samuele; Bataller Ramón; Brenner David A
NADPH oxidase in the liver: defensive, offensive, or fibrogenic?
Gastroenterology 2006;131(1):272-5.
2006: Schwabe Robert F; Seki Ekihiro; Brenner David A
Toll-like receptor signaling in the liver.
Gastroenterology 2006;130(6):1886-900.
2006: Lehmann Thorsten G; Luedde Tom; Schwabe Robert F; Bunzendahl Hartwig; Samulski R Jude; Lemasters John J; Brenner David A
Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2006;12(4):550-9.
2006: Schwabe Robert F; Brenner David A
Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(4):G583-9.
2005: Osawa Yosuke; Hannun Yusuf A; Proia Richard L; Brenner David A
Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver.
Hepatology (Baltimore, Md.) 2005;42(6):1320-8.
2005: Siegmund Sören V; Brenner David A
Molecular pathogenesis of alcohol-induced hepatic fibrosis.
Alcoholism, clinical and experimental research 2005;29(11 Suppl):102S-109S.
2005: Stefanovic Lela; Brenner David A; Stefanovic Branko
Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils.
Experimental biology and medicine (Maywood, N.J.) 2005;230(8):573-86.
2005: Schnabl Bernd; Hu Kanghong; Mühlbauer Marcus; Hellerbrand Claus; Stefanovic Branko; Brenner David A; Schölmerich Jürgen
Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10.
Biochemical and biophysical research communications 2005;335(1):87-96.
2005: Yang Liu; Magness Scott T; Bataller Ramon; Rippe Richard A; Brenner David A
NF-kappaB activation in Kupffer cells after partial hepatectomy.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(3):G530-8.
2005: Yang Liu; Bataller Ramón; Dulyx Jennyfer; Coffman Thomas M; Ginès Pere; Rippe Richard A; Brenner David A
Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.
Journal of hepatology 2005;43(2):317-23.
2005: Osawa Yosuke; Uchinami Hiroshi; Bielawski Jacek; Schwabe Robert F; Hannun Yusuf A; Brenner David A
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
The Journal of biological chemistry 2005;280(30):27879-87.
2005: Uehara Tetsuya; Bennett Brydon; Sakata Steve T; Satoh Yoshitaka; Bilter Graham K; Westwick John K; Brenner David A
JNK mediates hepatic ischemia reperfusion injury.
Journal of hepatology 2005;42(6):850-9.
2005: Li Yankun; Schwabe Robert F; DeVries-Seimon Tracie; Yao Pin Mei; Gerbod-Giannone Marie-Christine; Tall Alan R; Davis Roger J; Flavell Richard; Brenner David A; Tabas Ira
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis.
The Journal of biological chemistry 2005;280(23):21763-72.
2005: Siegmund Sören V; Uchinami Hiroshi; Osawa Yosuke; Brenner David A; Schwabe Robert F
Anandamide induces necrosis in primary hepatic stellate cells.
Hepatology (Baltimore, Md.) 2005;41(5):1085-95.
2005: Bataller Ramón; Gäbele Erwin; Parsons Christopher J; Morris Terry; Yang Liu; Schoonhoven Robert; Brenner David A; Rippe Richard A
Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats.
Hepatology (Baltimore, Md.) 2005;41(5):1046-55.
2005: Luedde Tom; Assmus Ulrike; Wüstefeld Torsten; Meyer zu Vilsendorf Andreas; Roskams Tania; Schmidt-Supprian Mark; Rajewsky Klaus; Brenner David A; Manns Michael P; Pasparakis Manolis; Trautwein Christian
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.
The Journal of clinical investigation 2005;115(4):849-59.
2005: Gäbele Erwin; Reif Shimon; Tsukada Shigeki; Bataller Ramon; Yata Yutaka; Morris Terry; Schrum Laura W; Brenner David A; Rippe Richard A
The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation.
The Journal of biological chemistry 2005;280(14):13374-82.
2005: Siegmund Soren V; Dooley Steven; Brenner David A
Molecular mechanisms of alcohol-induced hepatic fibrosis.
Digestive diseases (Basel, Switzerland) 2005;23(3-4):264-74.
2005: Adachi Masayuki; Brenner David A
Clinical syndromes of alcoholic liver disease.
Digestive diseases (Basel, Switzerland) 2005;23(3-4):255-63.
2004: Magness Scott T; Bataller Ramón; Yang Liu; Brenner David A
A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations.
Hepatology (Baltimore, Md.) 2004;40(5):1151-9.
2004: Parsons Christopher J; Bradford Blair U; Pan Clark Q; Cheung Ellen; Schauer Michael; Knorr Andreas; Krebs Barbara; Kraft Sabine; Zahn Stefan; Brocks Bodo; Feirt Nikki; Mei Baisong; Cho Myung-Sam; Ramamoorthi Roopa; Roldan Greg; Ng Paul; Lum Peggy; Hirth-Dietrich Claudia; Tomkinson Adrian; Brenner David A
Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats.
Hepatology (Baltimore, Md.) 2004;40(5):1106-15.
2004: Uehara Tetsuya; Xi Peng Xing; Bennett Brydon; Satoh Yoshi; Friedman Glenn; Currin Robert; Brenner David A; Lemasters John
c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation.
Transplantation 2004;78(3):324-32.
2004: Magness Scott T; Jijon Humberto; Van Houten Fisher Nancy; Sharpless Ned E; Brenner David A; Jobin Christian
In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1561-70.
2004: Black Dalliah; Bird Mark A; Hayden Melissa; Schrum Laura W; Lange Patricia; Samson Charles; Hatano Etsuro; Rippe Richard A; Brenner David A; Behrns Kevin E
TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein.
Surgery 2004;135(6):619-28.
2004: Black Dalliah; Bird Mark A; Samson Charles M; Lyman Suzanne; Lange Patty A; Schrum Laura W; Qian Ting; Lemasters J J; Brenner David A; Rippe Richard A; Behrns Kevin E
Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism.
Journal of hepatology 2004;40(6):942-51.
2004: Lindquist Jeffrey N; Parsons Christopher J; Stefanovic Branko; Brenner David A
Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region.
The Journal of biological chemistry 2004;279(22):23822-9.
2004: Schwabe Robert F; Uchinami Hiroshi; Qian Ting; Bennett Brydon L; Lemasters John J; Brenner David A
Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(6):720-2.
2004: Bataller Ramó; Paik Yong-Han; Lindquist Jeffrey N; Lemasters John J; Brenner David A
Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells.
Gastroenterology 2004;126(2):529-40.
2004: Stefanovic Branko; Stefanovic Lela; Schnabl Bernd; Bataller Ramon; Brenner David A
TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis.
Molecular and cellular biology 2004;24(4):1758-68.
2004: Brenner David A
Gastrointestinal basic science 2002-2003: the year in review.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2004;2(1):9-13.
2003: Bataller Ramon; Schwabe Robert F; Choi Youkyung H; Yang Liu; Paik Yong Han; Lindquist Jeffrey; Qian Ting; Schoonhoven Robert; Hagedorn Curt H; Lemasters John J; Brenner David A
NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.
The Journal of clinical investigation 2003;112(9):1383-94.
2003: Schwabe Robert F; Bataller Ramon; Brenner David A
Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(5):G949-58.
2003: Bataller Ramón; Gäbele Erwin; Schoonhoven Robert; Morris Terry; Lehnert Mark; Yang Liu; Brenner David A; Rippe Richard A
Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(3):G642-51.
2003: Lehmann Thorsten G; Wheeler Michael D; Froh Matthias; Schwabe Robert F; Bunzendahl Hartwig; Samulski R Jude; Lemasters John J; Brenner David A; Thurman Ronald G
Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat.
Transplantation 2003;76(1):28-37.
2003: Kweon Young-Oh; Paik Yong-Han; Schnabl Bernd; Qian Ting; Lemasters John J; Brenner David A
Gliotoxin-mediated apoptosis of activated human hepatic stellate cells.
Journal of hepatology 2003;39(1):38-46.
2003: Paik Yong-Han; Schwabe Robert F; Bataller Ramón; Russo Maria P; Jobin Christian; Brenner David A
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells.
Hepatology (Baltimore, Md.) 2003;37(5):1043-55.
2003: Oh Ki-Wan; Qian Ting; Brenner David A; Lemasters John J
Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(1):44-52.
2003: Luedde Tom; Rodriguez Maria E; Tacke Frank; Xiong Yue; Brenner David A; Trautwein Christian
p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver.
Hepatology (Baltimore, Md.) 2003;37(4):833-41.
2003: Schwabe Robert F; Bradham Cynthia A; Uehara Tetsuya; Hatano Etsuro; Bennett Brydon L; Schoonhoven Robert; Brenner David A
c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration.
Hepatology (Baltimore, Md.) 2003;37(4):824-32.
2003: Bataller Ramón; North Kari E; Brenner David A
Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal.
Hepatology (Baltimore, Md.) 2003;37(3):493-503.
2003: Reif Shimon; Lang Alon; Lindquist Jeffery N; Yata Yutaka; Gabele Erwin; Scanga Andrew; Brenner David A; Rippe Richard A
The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression.
The Journal of biological chemistry 2003;278(10):8083-90.
2003: Yata Yutaka; Scanga Andrew; Gillan Andrea; Yang Liu; Reif Shimon; Breindl Michael; Brenner David A; Rippe Richard A
DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells.
Hepatology (Baltimore, Md.) 2003;37(2):267-76.
2003: Gäbele Erwin; Brenner David A; Rippe Richard A
Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell.
Frontiers in bioscience : a journal and virtual library 2003;8():d69-77.
2003: Stefanovic Branko; Brenner David A
5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo.
The Journal of biological chemistry 2003;278(2):927-33.
2002: Kim Young-Soo; Schwabe Robert F; Qian Ting; Lemasters John J; Brenner David A
TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells.
Hepatology (Baltimore, Md.) 2002;36(6):1498-508.
2002: Lemasters John J; Qian Ting; He Lihua; Kim Jae-Sung; Elmore Steven P; Cascio Wayne E; Brenner David A
Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy.
Antioxidants & redox signaling 2002;4(5):769-81.
2002: Samson Charles M; Schrum Laura W; Bird Mark A; Lange Patricia A; Brenner David A; Rippe Richard A; Behrns Kevin E
Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism.
Surgery 2002;132(3):441-9.
2002: Magness Scott T; Maeda Nobuyo; Brenner David A
An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria.
Blood 2002;100(4):1470-7.
2002: Liedtke Christian; Plümpe Jörg; Kubicka Stefan; Bradham Cynthia A; Manns Michael P; Brenner David A; Trautwein Christian
Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells.
Hepatology (Baltimore, Md.) 2002;36(2):315-25.
2002: Russo Maria P; Bennett Brydon L; Manning Anthony M; Brenner David A; Jobin Christian
Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas.
American journal of physiology. Cell physiology 2002;283(1):C347-57.
2002: Stefanovic Branko; Schnabl Bernd; Brenner David A
Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy.
The Journal of biological chemistry 2002;277(20):18229-37.
2002: Schnabl Bernd; Choi Youkyung Hwang; Olsen John C; Hagedorn Curt H; Brenner David A
Immortal activated human hepatic stellate cells generated by ectopic telomerase expression.
Laboratory investigation; a journal of technical methods and pathology 2002;82(3):323-33.
2001: Hatano E; Brenner D A
Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(6):G1357-68.
2001: Schnabl B; Bradham C A; Bennett B L; Manning A M; Stefanovic B; Brenner D A
TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells.
Hepatology (Baltimore, Md.) 2001;34(5):953-63.
2001: Bradham C A; Hatano E; Brenner D A
Dominant-negative TAK1 induces c-Myc and G(0) exit in liver.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(5):G1279-89.
2001: Enomoto N; Schemmer P; Ikejima K; Takei Y; Sato N; Brenner D A; Thurman R G
Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide.
Alcoholism, clinical and experimental research 2001;25(9):1360-7.
2001: Bataller R; Brenner D A
Hepatic stellate cells as a target for the treatment of liver fibrosis.
Seminars in liver disease 2001;21(3):437-51.
2001: Schnabl B; Kweon Y O; Frederick J P; Wang X F; Rippe R A; Brenner D A
The role of Smad3 in mediating mouse hepatic stellate cell activation.
Hepatology (Baltimore, Md.) 2001;34(1):89-100.
2001: Schwabe R F; Schnabl B; Kweon Y O; Brenner D A
CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(11):6812-9.
2001: Kono H; Nakagami M; Rusyn I; Connor H D; Stefanovic B; Brenner D A; Mason R P; Arteel G E; Thurman R G
Development of an animal model of chronic alcohol-induced pancreatitis in the rat.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(6):G1178-86.
2001: Hatano E; Bennett B L; Manning A M; Qian T; Lemasters J J; Brenner D A
NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis.
Gastroenterology 2001;120(5):1251-62.
2001: Schwabe R F; Bennett B L; Manning A M; Brenner D A
Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes.
Hepatology (Baltimore, Md.) 2001;33(1):81-90.
2001: Schrum L W; Bird M A; Salcher O; Burchardt E R; Grisham J W; Brenner D A; Rippe R A; Behrns K E
Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(1):G139-48.
2000: Lang A; Schrum L W; Schoonhoven R; Tuvia S; Solís-Herruzo J A; Tsukamoto H; Brenner D A; Rippe R A
Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(6):G1333-42.
2000: Lehmann T G; Wheeler M D; Schwabe R F; Connor H D; Schoonhoven R; Bunzendahl H; Brenner D A; Jude Samulski R; Zhong Z; Thurman R G
Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat.
Hepatology (Baltimore, Md.) 2000;32(6):1255-64.
2000: Lindquist J N; Kauschke S G; Stefanovic B; Burchardt E R; Brenner D A
Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA.
Nucleic acids research 2000;28(21):4306-16.
2000: Lang A; Schoonhoven R; Tuvia S; Brenner D A; Rippe R A
Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells.
Journal of hepatology 2000;33(1):49-58.
2000: Enomoto N; Ikejima K; Yamashina S; Enomoto A; Nishiura T; Nishimura T; Brenner D A; Schemmer P; Bradford B U; Rivera C A; Zhong Z; Thurman R G
Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(1):G100-6.
2000: Magness S T; Tugores A; Brenner D A
Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells.
Blood 2000;95(11):3568-77.
2000: Böcker U; Schottelius A; Watson J M; Holt L; Licato L L; Brenner D A; Sartor R B; Jobin C
Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells.
The Journal of biological chemistry 2000;275(16):12207-13.
2000: Hatano E; Bradham C A; Stark A; Iimuro Y; Lemasters J J; Brenner D A
The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes.
The Journal of biological chemistry 2000;275(16):11814-23.
2000: Enomoto N; Ikejima K; Bradford B U; Rivera C A; Kono H; Goto M; Yamashina S; Schemmer P; Kitamura T; Oide H; Takei Y; Hirose M; Shimizu H; Miyazaki A; Brenner D A; Sato N; Thurman R G
Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury.
Journal of gastroenterology and hepatology 2000;15 Suppl():D20-5.
2000: Schrum L W; Black D; Iimuro Y; Rippe R A; Brenner D A; Behrns K E
c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy.
The Journal of surgical research 2000;88(2):142-9.
2000: Stefanovic B; Lindquist J; Brenner D A
The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix.
Nucleic acids research 2000;28(2):641-7.
2000: Lindquist J N; Stefanovic B; Brenner D A
Regulation of collagen alpha1(I) expression in hepatic stellate cells.
Journal of gastroenterology 2000;35 Suppl 12():80-3.
2000: Brenner D A; Waterboer T; Choi S K; Lindquist J N; Stefanovic B; Burchardt E; Yamauchi M; Gillan A; Rippe R A
New aspects of hepatic fibrosis.
Journal of hepatology 2000;32(1 Suppl):32-8.
1999: Rusyn I; Bradham C A; Cohn L; Schoonhoven R; Swenberg J A; Brenner D A; Thurman R G
Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms.
Carcinogenesis 1999;20(11):2095-100.
1999: Rippe R A; Schrum L W; Stefanovic B; Solís-Herruzo J A; Brenner D A
NF-kappaB inhibits expression of the alpha1(I) collagen gene.
DNA and cell biology 1999;18(10):751-61.
1999: Solís-Herruzo J A; Rippe R A; Schrum L W; de La Torre P; García I; Jeffrey J J; Muñoz-Yagüe T; Brenner D A
Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts.
The Journal of biological chemistry 1999;274(43):30919-26.
1999: Enomoto N; Yamashina S; Schemmer P; Rivera C A; Bradford B U; Enomoto A; Brenner D A; Thurman R G
Estriol sensitizes rat Kupffer cells via gut-derived endotoxin.
The American journal of physiology 1999;277(3 Pt 1):G671-7.
1999: Jobin C; Bradham C A; Russo M P; Juma B; Narula A S; Brenner D A; Sartor R B
Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3474-83.
1999: Lemasters J J; Qian T; Bradham C A; Brenner D A; Cascio W E; Trost L C; Nishimura Y; Nieminen A L; Herman B
Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death.
Journal of bioenergetics and biomembranes 1999;31(4):305-19.
1999: Uzawa K; Grzesik W J; Nishiura T; Kuznetsov S A; Robey P G; Brenner D A; Yamauchi M
Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(8):1272-80.
1999: Bradham C A; Schemmer P; Stachlewitz R F; Thurman R G; Brenner D A
Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells.
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 1999;5(4):282-93.
1999: Enomoto N; Yamashina S; Kono H; Schemmer P; Rivera C A; Enomoto A; Nishiura T; Nishimura T; Brenner D A; Thurman R G
Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells.
Hepatology (Baltimore, Md.) 1999;29(6):1680-9.
1999: Stefanovic B; Hellerbrand C; Brenner D A
Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA.
Molecular and cellular biology 1999;19(6):4334-42.
1999: Jobin C; Holt L; Bradham C A; Streetz K; Brenner D A; Sartor R B
TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4447-54.
1999: Ikejima K; Enomoto N; Seabra V; Ikejima A; Brenner D A; Thurman R G
Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells.
The American journal of physiology 1999;276(3 Pt 1):G591-8.
1999: Magness S T; Brenner D A
Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion.
Biochimica et biophysica acta 1999;1453(1):161-74.
1999: Hellerbrand C; Stefanovic B; Giordano F; Burchardt E R; Brenner D A
The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo.
Journal of hepatology 1999;30(1):77-87.
1999: Lemasters J J; Qian T; Trost L C; Herman B; Cascio W E; Bradham C A; Brenner D A; Nieminen A L
Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death.
Biochemical Society symposium 1999;66():205-22.
1998: Bradham C A; Qian T; Streetz K; Trautwein C; Brenner D A; Lemasters J J
The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release.
Molecular and cellular biology 1998;18(11):6353-64.
1998: Scarlett Y V; Brenner D A
Porphyrias.
Journal of clinical gastroenterology 1998;27(3):192-8.
1998: Brenner D A
Signal transduction during liver regeneration.
Journal of gastroenterology and hepatology 1998;13 Suppl():S93-5.
1998: Bradham C A; Plümpe J; Manns M P; Brenner D A; Trautwein C
Mechanisms of hepatic toxicity. I. TNF-induced liver injury.
The American journal of physiology 1998;275(3 Pt 1):G387-92.
1998: Lemasters J J; Nieminen A L; Qian T; Trost L C; Elmore S P; Nishimura Y; Crowe R A; Cascio W E; Bradham C A; Brenner D A; Herman B
The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.
Biochimica et biophysica acta 1998;1366(1-2):177-96.
1998: Hellerbrand C; Jobin C; Licato L L; Sartor R B; Brenner D A
Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells.
The American journal of physiology 1998;275(2 Pt 1):G269-78.
1998: Enomoto N; Ikejima K; Bradford B; Rivera C; Kono H; Brenner D A; Thurman R G
Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin.
Gastroenterology 1998;115(2):443-51.
1998: Licato L L; Brenner D A
Analysis of signaling protein kinases in human colon or colorectal carcinomas.
Digestive diseases and sciences 1998;43(7):1454-64.
1998: Magness S T; Tugores A; Diala E S; Brenner D A
Analysis of the human ferrochelatase promoter in transgenic mice.
Blood 1998;92(1):320-8.
1998: Jobin C; Hellerbrand C; Licato L L; Brenner D A; Sartor R B
Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors.
Gut 1998;42(6):779-87.
1998: Hellerbrand C; Jobin C; Iimuro Y; Licato L; Sartor R B; Brenner D A
Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor.
Hepatology (Baltimore, Md.) 1998;27(5):1285-95.
1998: Trautwein C; Rakemann T; Brenner D A; Streetz K; Licato L; Manns M P; Tiegs G
Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice.
Gastroenterology 1998;114(5):1035-45.
1998: Ikejima K; Enomoto N; Iimuro Y; Ikejima A; Fang D; Xu J; Forman D T; Brenner D A; Thurman R G
Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin.
The American journal of physiology 1998;274(4 Pt 1):G669-76.
1998: Scarlett Y V; Brenner D A; Bloomer J R
Hepatic porphyrias.
Clinics in liver disease 1998;2(1):77-102, vi.
1998: Iimuro Y; Nishiura T; Hellerbrand C; Behrns K E; Schoonhoven R; Grisham J W; Brenner D A
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.
The Journal of clinical investigation 1998;101(4):802-11.
1998: Jobin C; Panja A; Hellerbrand C; Iimuro Y; Didonato J; Brenner D A; Sartor R B
Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):410-8.
1998: Lemasters J J; Qian T; Elmore S P; Trost L C; Nishimura Y; Herman B; Bradham C A; Brenner D A; Nieminen A L
Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy.
BioFactors (Oxford, England) 1998;8(3-4):283-5.
1997: Licato L L; Keku T O; Wurzelmann J I; Murray S C; Woosley J T; Sandler R S; Brenner D A
In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia.
Gastroenterology 1997;113(5):1589-98.
1997: Stefanovic B; Hellerbrand C; Holcik M; Briendl M; Aliebhaber S; Brenner D A
Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells.
Molecular and cellular biology 1997;17(9):5201-9.
1997: Bradham C A; Stachlewitz R F; Gao W; Qian T; Jayadev S; Jenkins G; Hannun Y; Lemasters J J; Thurman R G; Brenner D A
Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases.
Hepatology (Baltimore, Md.) 1997;25(5):1128-35.
1997: Rippe R A; Umezawa A; Kimball J P; Breindl M; Brenner D A
Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription.
The Journal of biological chemistry 1997;272(3):1753-60.
1996: Westwick J K; Fleckenstein J; Yin M; Yang S Q; Bradham C A; Brenner D A; Diehl A M
Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo.
The American journal of physiology 1996;271(5 Pt 1):G780-90.
1996: Iimuro Y; Bradford B U; Gao W; Kadiiska M; Mason R P; Stefanovic B; Brenner D A; Thurman R G
Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat.
Molecular pharmacology 1996;50(3):656-61.
1996: Hellerbrand; Wang S C; Tsukamoto H; Brenner D A; Rippe R A
Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells.
Hepatology (Baltimore, Md.) 1996;24(3):670-6.
1996: Brenner D A
New functions for the aryl hydrocarbon receptor.
Hepatology (Baltimore, Md.) 1996;23(2):379-80.
1995: Magness S T; Brenner D A
Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells.
Human gene therapy 1995;6(10):1285-90.
1995: Kandil H M; Argenzio R A; Chen W; Berschneider H M; Stiles A D; Westwick J K; Rippe R A; Brenner D A; Rhoads J M
L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line.
The American journal of physiology 1995;269(4 Pt 1):G591-9.
1995: Westwick J K; Bielawska A E; Dbaibo G; Hannun Y A; Brenner D A
Ceramide activates the stress-activated protein kinases.
The Journal of biological chemistry 1995;270(39):22689-92.
1995: Rippe R A; Almounajed G; Brenner D A
Sp1 binding activity increases in activated Ito cells.
Hepatology (Baltimore, Md.) 1995;22(1):241-51.
1995: Westwick J K; Weitzel C; Leffert H L; Brenner D A
Activation of Jun kinase is an early event in hepatic regeneration.
The Journal of clinical investigation 1995;95(2):803-10.
1995: Stefanovic B; Hellerbrand C; Brenner D A
Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells.
Nucleic acids symposium series 1995;(33):212-4.
1995: Westwick J K; Brenner D A
Methods for analyzing c-Jun kinase.
Methods in enzymology 1995;255():342-59.
1994: Tugores A; Magness S T; Brenner D A
A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene.
The Journal of biological chemistry 1994;269(49):30789-97.
1994: Brenner D A; Rippe R A; Rhodes K; Trotter J F; Breindl M
Fibrogenesis and type I collagen gene regulation.
The Journal of laboratory and clinical medicine 1994;124(6):755-60.
1994: Diehl A M; Yin M; Fleckenstein J; Yang S Q; Lin H Z; Brenner D A; Westwick J; Bagby G; Nelson S
Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury.
The American journal of physiology 1994;267(4 Pt 1):G552-61.
1994: Westwick J K; Weitzel C; Minden A; Karin M; Brenner D A
Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase.
The Journal of biological chemistry 1994;269(42):26396-401.
1994: Rhodes K; Rippe R A; Umezawa A; Nehls M; Brenner D A; Breindl M
DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism.
Molecular and cellular biology 1994;14(9):5950-60.
1994: Magness S T; Tugores A; Christensen S R; Wagner-Mcpherson C; Evans G A; Naylor E W; Brenner D A
Deletion of the ferrochelatase gene in a patient with protoporphyria.
Human molecular genetics 1994;3(9):1695-7.
1994: Cox A D; Garcia A M; Westwick J K; Kowalczyk J J; Lewis M D; Brenner D A; Der C J
The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation.
The Journal of biological chemistry 1994;269(30):19203-6.
1994: Westwick J K; Cox A D; Der C J; Cobb M H; Hibi M; Karin M; Brenner D A
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6030-4.
1991: Houglum K P; Brenner D A; Chojkier M
Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation.
The American journal of clinical nutrition 1991;54(6 Suppl):1141S-1143S.
1991: Houglum K; Brenner D A; Chojkier M
d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation.
The Journal of clinical investigation 1991;87(6):2230-5.
1989: Chojkier M; Houglum K; Solis-Herruzo J; Brenner D A
Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation?
The Journal of biological chemistry 1989;264(28):16957-62.
1989: Chojkier M; Brenner D A; Leffert H L
Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes.
The Journal of biological chemistry 1989;264(16):9583-91.
1989: Rippe R A; Lorenzen S I; Brenner D A; Breindl M
Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene.
Molecular and cellular biology 1989;9(5):2224-7.
1988: Chojkier M; Flaherty M; Peterkofsky B; Majmudar G H; Spanheimer R G; Brenner D A
Different mechanisms decrease hepatic collagen and albumin production in fasted rats.
Hepatology (Baltimore, Md.) 1988;8(5):1040-5.
1988: Solis-Herruzo J A; Brenner D A; Chojkier M
Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts.
The Journal of biological chemistry 1988;263(12):5841-5.
1987: Brenner D A; Chojkier M
Acetaldehyde increases collagen gene transcription in cultured human fibroblasts.
The Journal of biological chemistry 1987;262(36):17690-5.

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