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Hong Wu
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Research Profile (preview)
Chemicals & Drugs
Living Beings
Physiology
Anatomy
Disorders
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Network (preview)
14
Liu, Xin
9
Groszer, Matthias
8
Gao, Jing
8
Lesche, Ralf
8
Stiles, Bangyan
6
Mulholland, David
6
Jiao, Jing
5
Kertesz, Nathalie
5
Kornblum, Harley
5
Wang, Ying
4
Witte, Owen
4
Wong, Kelly
3
Xin, Li
3
Teitell, Michael
3
Liu, Bin
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Publications
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Geonetwork of Hong Wu (preview)
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All Publications
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2009: Mulholland David J; Xin Li; Morim Ashkan; Lawson Devon; Witte Owen; Wu Hong
Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model.
Cancer research 2009;69(22):8555-62.
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2009: Hill Reginald; Wu Hong
PTEN, stem cells, and cancer stem cells.
The Journal of biological chemistry 2009;284(18):11755-9.
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2009: Gregorian Caroline; Nakashima Jonathan; Le Belle Janel; Ohab John; Kim Rachel; Liu Annie; Smith Kate Barzan; Groszer Matthias; Garcia A Denise; Sofroniew Michael V; Carmichael S Thomas; Kornblum Harley I; Liu Xin; Wu Hong
Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(6):1874-86.
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2009: Ruan Hongmei; Li Jian; Ren Shuxun; Gao Jing; Li Guangping; Kim Rachel; Wu Hong; Wang Yibin
Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury.
Journal of molecular and cellular cardiology 2009;46(2):193-200.
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2009: Conway Anne E; Lindgren Anne; Galic Zoran; Pyle April D; Wu Hong; Zack Jerome A; Pelligrini Matteo; Teitell Michael A; Clark Amander T
A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors.
Stem cells (Dayton, Ohio) 2009;27(1):18-28.
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2009: Wang Shutao; Wang Hao; Jiao Jing; Chen Kuan-Ju; Owens Gwen E; Kamei Ken-ichiro; Sun Jing; Sherman David J; Behrenbruch Christian P; Wu Hong; Tseng Hsian-Rong
Three-dimensional nanostructured substrates toward efficient capture of circulating tumor cells.
Angewandte Chemie (International ed. in English) 2009;48(47):8970-3.
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2008: Valamehr Bahram; Jonas Steven J; Polleux Julien; Qiao Rong; Guo Shuling; Gschweng Eric H; Stiles Bangyan; Kam Korey; Luo Tzy-Jiun M; Witte Owen N; Liu Xin; Dunn Bruce; Wu Hong
Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14459-64.
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2008: Burton Jeremy B; Johnson Mai; Sato Makoto; Koh Sok Boon S; Mulholland David J; Stout David; Chatziioannou Arion F; Phelps Michael E; Wu Hong; Wu Lily
Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer.
Nature medicine 2008;14(8):882-8.
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2008: Guo Wei; Lasky Joseph L; Chang Chun-Ju; Mosessian Sherly; Lewis Xiaoman; Xiao Yun; Yeh Jennifer E; Chen James Y; Iruela-Arispe M Luisa; Varella-Garcia Marileila; Wu Hong
Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation.
Nature 2008;453(7194):529-33.
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2008: Chang Chun-Ju; Mulholland David J; Valamehr Bahram; Mosessian Sherly; Sellers William R; Wu Hong
PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression.
Molecular and cellular biology 2008;28(10):3281-9.
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2008: Mulholland David J; Jiao Jing; Wu Hong
Hormone refractory prostate cancer: Lessons learned from the PTEN prostate cancer model.
Advances in experimental medicine and biology 2008;617():87-95.
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2007: Memarzadeh Sanaz; Xin Li; Mulholland David J; Mansukhani Alka; Wu Hong; Teitell Michael A; Witte Owen N
Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor.
Cancer cell 2007;12(6):572-85.
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2007: Jiao Jing; Wang Shunyou; Qiao Rong; Vivanco Igor; Watson Philip A; Sawyers Charles L; Wu Hong
Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development.
Cancer research 2007;67(13):6083-91.
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2007: Tahk Samuel; Liu Bin; Chernishof Vasili; Wong Kelly A; Wu Hong; Shuai Ke
Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11643-8.
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2007: Vivanco Igor; Palaskas Nicolaos; Tran Chris; Finn Stephen P; Getz Gad; Kennedy Norman J; Jiao Jing; Rose Joshua; Xie Wanling; Loda Massimo; Golub Todd; Mellinghoff Ingo K; Davis Roger J; Wu Hong; Sawyers Charles L
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.
Cancer cell 2007;11(6):555-69.
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2006: Horvath S; Zhang B; Carlson M; Lu K V; Zhu S; Felciano R M; Laurance M F; Zhao W; Qi S; Chen Z; Lee Y; Scheck A C; Liau L M; Wu H; Geschwind D H; Febbo P G; Kornblum H I; Cloughesy T F; Nelson S F; Mischel P S
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17402-7.
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2006: Freeman Dan; Lesche Ralf; Kertesz Nathalie; Wang Shungyou; Li Gang; Gao Jing; Groszer Matthias; Martinez-Diaz Hilda; Rozengurt Nora; Thomas George; Liu Xin; Wu Hong
Genetic background controls tumor development in PTEN-deficient mice.
Cancer research 2006;66(13):6492-6.
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2006: Xu Xiaoling; Kobayashi Shogo; Qiao Wenhui; Li Cuiling; Xiao Cuiying; Radaeva Svetlana; Stiles Bangyan; Wang Rui-Hong; Ohara Nobuya; Yoshino Tadashi; LeRoith Derek; Torbenson Michael S; Gores Gregory J; Wu Hong; Gao Bin; Deng Chu-Xia
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
The Journal of clinical investigation 2006;116(7):1843-52.
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2006: Lei Qunying; Jiao Jing; Xin Li; Chang Chun-Ju; Wang Shunyou; Gao Jing; Gleave Martin E; Witte Owen N; Liu Xin; Wu Hong
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.
Cancer cell 2006;9(5):367-78.
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2006: Guo Wei; Lasky Joseph L; Wu Hong
Cancer stem cells.
Pediatric research 2006;59(4 Pt 2):59R-64R.
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2006: Stiles Bangyan L; Kuralwalla-Martinez Christine; Guo Wei; Gregorian Caroline; Wang Ying; Tian Jide; Magnuson Mark A; Wu Hong
Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.
Molecular and cellular biology 2006;26(7):2772-81.
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2006: Li Gang; Hu Yingchun; Huo Yanying; Liu Minli; Freeman Dan; Gao Jing; Liu Xin; Wu De-Chang; Wu Hong
PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin.
The Journal of biological chemistry 2006;281(16):10663-8.
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2006: Tsai Peter T; Ohab John J; Kertesz Nathalie; Groszer Matthias; Matter Cheryl; Gao Jing; Liu Xin; Wu Hong; Carmichael S Thomas
A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(4):1269-74.
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2006: Mulholland D J; Dedhar S; Wu H; Nelson C C
PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer.
Oncogene 2006;25(3):329-37.
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2006: Groszer Matthias; Erickson Rebecca; Scripture-Adams Deirdre D; Dougherty Joseph D; Le Belle Janel; Zack Jerome A; Geschwind Daniel H; Liu Xin; Kornblum Harley I; Wu Hong
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(1):111-6.
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2005: Stanger Ben Z; Stiles Bangyan; Lauwers Gregory Y; Bardeesy Nabeel; Mendoza Michael; Wang Ying; Greenwood Amy; Cheng Kuang-hung; McLaughlin Margaret; Brown Dennis; Depinho Ronald A; Wu Hong; Melton Douglas A; Dor Yuval
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.
Cancer cell 2005;8(3):185-95.
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2005: Nakano Ichiro; Paucar Andres A; Bajpai Ruchi; Dougherty Joseph D; Zewail Amani; Kelly Theresa K; Kim Kevin J; Ou Jing; Groszer Matthias; Imura Tetsuya; Freije William A; Nelson Stanley F; Sofroniew Michael V; Wu Hong; Liu Xin; Terskikh Alexey V; Geschwind Daniel H; Kornblum Harley I
Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.
The Journal of cell biology 2005;170(3):413-27.
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2005: Yue Qing; Groszer Matthias; Gil Jose S; Berk Arnold J; Messing Albee; Wu Hong; Liu Xin
PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization.
Development (Cambridge, England) 2005;132(14):3281-91.
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2005: Lasky Joseph L; Wu Hong
Notch signaling, brain development, and human disease.
Pediatric research 2005;57(5 Pt 2):104R-109R.
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2005: Kurlawalla-Martinez Christine; Stiles Bangyan; Wang Ying; Devaskar Sherin U; Kahn Barbara B; Wu Hong
Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue.
Molecular and cellular biology 2005;25(6):2498-510.
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2005: Shi Yijiang; Sharma Anushree; Wu Hong; Lichtenstein Alan; Gera Joseph
Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway.
The Journal of biological chemistry 2005;280(12):10964-73.
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2005: Liu Bin; Yang Randy; Wong Kelly A; Getman Crescent; Stein Natalie; Teitell Michael A; Cheng Genhong; Wu Hong; Shuai Ke
Negative regulation of NF-kappaB signaling by PIAS1.
Molecular and cellular biology 2005;25(3):1113-23.
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2004: Kertesz Nathalie; Wu Jun; Chen Tim H-P; Sucov Henry M; Wu Hong
The role of erythropoietin in regulating angiogenesis.
Developmental biology 2004;276(1):101-10.
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2004: Stiles Bangyan; Groszer Matthias; Wang Shunyou; Jiao Jing; Wu Hong
PTENless means more.
Developmental biology 2004;273(2):175-84.
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2004: Liu Bin; Mink Sheldon; Wong Kelly A; Stein Natalie; Getman Crescent; Dempsey Paul W; Wu Hong; Shuai Ke
PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity.
Nature immunology 2004;5(9):891-8.
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2004: Chang Chun-Ju; Freeman Daniel J; Wu Hong
PTEN regulates Mdm2 expression through the P1 promoter.
The Journal of biological chemistry 2004;279(28):29841-8.
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2004: Wong Kelly A; Kim Rachel; Christofk Heather; Gao Jing; Lawson Gregory; Wu Hong
Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life.
Molecular and cellular biology 2004;24(12):5577-86.
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2004: Sundaresan G; Paulmurugan R; Berger F; Stiles B; Nagayama Y; Wu H; Gambhir S S
MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene.
Gene therapy 2004;11(7):609-18.
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2004: Stiles Bangyan; Wang Ying; Stahl Andreas; Bassilian Sara; Lee W Paul; Kim Yoon-Jung; Sherwin Robert; Devaskar Sherin; Lesche Ralf; Magnuson Mark A; Wu Hong
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected].
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2082-7.
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2003: Tsai Peter T; Lee Robert A; Wu Hong
BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis.
Blood 2003;102(12):3947-53.
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2003: Freeman Daniel J; Li Andrew G; Wei Gang; Li Heng-Hong; Kertesz Nathalie; Lesche Ralf; Whale Andrew D; Martinez-Diaz Hilda; Rozengurt Nora; Cardiff Robert D; Liu Xuan; Wu Hong
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.
Cancer cell 2003;3(2):117-30.
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2002: Li Gang; Robinson Gertraud W; Lesche Ralf; Martinez-Diaz Hilda; Jiang Zhaorong; Rozengurt Nora; Wagner Kay-Uwe; Wu De-Chang; Lane Timothy F; Liu Xin; Hennighausen Lothar; Wu Hong
Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.
Development (Cambridge, England) 2002;129(17):4159-70.
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2002: Jegalian Armin G; Wu Hong
Differential roles of SOCS family members in EpoR signal transduction.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(8):853-60.
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2002: Kertesz Nathalie; Samson Jérôme; Debacker Cécile; Wu Hong; Labastie Marie-Claude
Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases.
Gene 2002;294(1-2):13-24.
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2002: Stiles Bangyan; Gilman Valeriya; Khanzenzon Natalya; Lesche Ralf; Li Annie; Qiao Rong; Liu Xin; Wu Hong
Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.
Molecular and cellular biology 2002;22(11):3842-51.
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2002: Jegalian Armin G; Acurio Adriana; Dranoff Glenn; Wu Hong
Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3.
Blood 2002;99(7):2603-5.
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2002: Lesche Ralf; Groszer Matthias; Gao Jing; Wang Ying; Messing Albee; Sun Hong; Liu Xin; Wu Hong
Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.
Genesis (New York, N.Y. : 2000) 2002;32(2):148-9.
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2002: Jegalian Armin G; Wu Hong
Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.
The Journal of biological chemistry 2002;277(3):2345-52.
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2001: Groszer M; Erickson R; Scripture-Adams D D; Lesche R; Trumpp A; Zack J A; Kornblum H I; Liu X; Wu H
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.
Science (New York, N.Y.) 2001;294(5549):2186-9.
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2001: Lee R; Kertesz N; Joseph S B; Jegalian A; Wu H
Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis.
Blood 2001;98(5):1408-15.
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2000: Satterthwaite A B; Willis F; Kanchanastit P; Fruman D; Cantley L C; Helgason C D; Humphries R K; Lowell C A; Simon M; Leitges M; Tarakhovsky A; Tedder T F; Lesche R; Wu H; Witte O N
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6687-92.
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1999: Wu H; Lee S H; Gao J; Liu X; Iruela-Arispe M L
Inactivation of erythropoietin leads to defects in cardiac morphogenesis.
Development (Cambridge, England) 1999;126(16):3597-605.
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