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Malcolm Brenner

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Ulrike Gerdemann; Stephen M Gottschalk; Helen E Heslop; Usha L Katari; Jacqueline M Keirnan; Alana Kennedy-Nasser; Laura Keukens; Malcolm K Brenner; Anne P de Pagter; Chinh T Q Nguyen; Carlos A Ramos; Cliona M Rooney; Ann Leen
Immunotherapeutic strategies to prevent and treat human herpesvirus 6 reactivation after allogeneic stem cell transplantation.
Carlos A Ramos; Barbara Savoldo; Erich M Sturgis; Gayatri M Vyas; Matthew L Anderson; Malcolm K Brenner; Ulrike Gerdemann; Helen E Heslop; Ann Leen; Neeharika Narala; Cliona M Rooney
Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignancies.
Donald Shaffer; Andrea M Sheehan; Zhongzhen Yi; Catherine M Bollard; Malcolm K Brenner; Helen E Heslop; Cheryl C Rodgers; Cliona M Rooney; Stephen Gottschalk
Aggressive peripheral CD70-positive T-cell lymphoma associated with severe chronic active EBV infection.

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2013: Ulrike Gerdemann; Stephen M Gottschalk; Helen E Heslop; Usha L Katari; Jacqueline M Keirnan; Alana Kennedy-Nasser; Laura Keukens; Malcolm K Brenner; Anne P de Pagter; Chinh T Q Nguyen; Carlos A Ramos; Cliona M Rooney; Ann Leen
Immunotherapeutic strategies to prevent and treat human herpesvirus 6 reactivation after allogeneic stem cell transplantation.
Blood 2013;121(1):207-18.
2013: Carlos A Ramos; Barbara Savoldo; Erich M Sturgis; Gayatri M Vyas; Matthew L Anderson; Malcolm K Brenner; Ulrike Gerdemann; Helen E Heslop; Ann Leen; Neeharika Narala; Cliona M Rooney
Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignancies.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2013;36(1):66-76.
2012: Donald Shaffer; Andrea M Sheehan; Zhongzhen Yi; Catherine M Bollard; Malcolm K Brenner; Helen E Heslop; Cheryl C Rodgers; Cliona M Rooney; Stephen Gottschalk
Aggressive peripheral CD70-positive T-cell lymphoma associated with severe chronic active EBV infection.
Pediatric blood & cancer 2012;59(4):758-61.
2012: Ulrike Gerdemann; Stephen Gottschalk; Helen E Heslop; Leslie E Huye; Usha L Katari; Jacqueline M Keirnan; Malcolm K Brenner; Anne S Christin; Sravya Ennamuri; Serena K Perna; Cliona M Rooney; Ryu Yanagisawa; Ann Leen
Rapidly generated multivirus-specific cytotoxic T lymphocytes for the prophylaxis and treatment of viral infections.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(8):1622-32.
2011: Chrystal U Louis; Zhuyong Mei; G Douglas Myers; Martin Pule; Cliona M Rooney; Claudia Rossig; Heidi V Russell; Barbara Savoldo; Meng-Fen Wu; Eric Yvon; Oumar Diouf; Gianpietro Dotti; Adrian P Gee; Helen E Heslop; Enli Liu; Hao Liu; Malcolm K Brenner
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma.
Blood 2011;118(23):6050-6.
2011: Ulrike Gerdemann; Stephen Gottschalk; Helen E Heslop; Usha Katari; Catherine M Bollard; Malcolm K Brenner; Anne S Christin; Conrad R Cruz; Cliona M Rooney; Alexandra Rousseau; Barbara Savoldo; Tamara Tripic; Juan F Vera; Ann Leen
Cytotoxic T lymphocytes simultaneously targeting multiple tumor-associated antigens to treat EBV negative lymphoma.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(12):2258-68.
2011: Antonio Di Stasi; Gianpietro Dotti; April Durett; Yuriko Fujita; Adrian P Gee; Bambi Grilley; Helen E Heslop; Alana Kennedy-Nasser; Robert A Krance; Enli Liu; Hao Liu; Caridad Martinez; Cliona M Rooney; Barbara Savoldo; John Schindler; David M Spencer; Karin C Straathof; Siok-Keen Tey; Conrad R Cruz; Malcolm K Brenner
Inducible apoptosis as a safety switch for adoptive cell therapy.
The New England journal of medicine 2011;365(18):1673-83.
2011: Fatma Visal Okur; Madhusudan Peshwa; Eric Yvon; Ettore Biagi; George Carrum; Gianpietro Dotti; Joseph C Fratantoni; Helen Heslop; Linhong Li; Martha P Mims; Malcolm K Brenner
Comparison of two CD40-ligand/interleukin-2 vaccines in patients with chronic lymphocytic leukemia.
Cytotherapy 2011;13(9):1128-39.
2011: Concetta Quintarelli; Gianpietro Dotti; Sayyeda T Hasan; BIAGIO DE ANGELIS; Valentina Hoyos; Santa Errichiello; Martha P Mims; Luigia Luciano; Jessica Shafer; Ann Leen; Helen E Heslop; Cliona M Rooney; Fabrizio Pane; Malcolm K Brenner; Barbara Savoldo
High-avidity cytotoxic T lymphocytes specific for a new PRAME-derived peptide can target leukemic and leukemic-precursor cells.
Blood 2011;117(12):3353-62.
2011: Yu-Feng Lin; David R Lairson; Wenyaw Chan; Xianglin L Du; Kathryn S Leung; Alana A Kennedy-Nasser; Caridad A Martinez; Helen E Heslop; Malcolm K Brenner; Robert A Krance
Children with acute leukemia: a comparison of outcomes from allogeneic blood stem cell and bone marrow transplantation.
Pediatric blood & cancer 2011;56(1):143-51.
2010: Chrystal U Louis; Karin Straathof; Catherine M Bollard; Sravya Ennamuri; Claudia Gerken; Teresita T Lopez; M Helen Huls; Andrea Sheehan; Meng-Fen Wu; Hao Liu; Adrian Gee; Malcolm K Brenner; Cliona M Rooney; Helen E Heslop; Stephen Gottschalk
Adoptive transfer of EBV-specific T cells results in sustained clinical responses in patients with locoregional nasopharyngeal carcinoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2010;33(9):983-90.
2010: John A Craddock; An Lu; Adham Bear; Martin Pule; Malcolm K Brenner; Cliona M Rooney; Aaron E Foster
Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2010;33(8):780-8.
2010: Conrad Russell Cruz; Patrick J Hanley; Hao Liu; Vicky Torrano; Yu-Feng Lin; James A Arce; Stephen Gottschalk; Barbara Savoldo; Gianpietro Dotti; Chrystal U Louis; Ann M Leen; Adrian P Gee; Cliona M Rooney; Malcolm K Brenner; Catherine M Bollard; Helen E Heslop
Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience.
Cytotherapy 2010;12(6):743-9.
2010: Yu-Feng Lin; David R Lairson; Wenyaw Chan; Xianglin L Du; Kathryn S Leung; Alana A Kennedy-Nasser; Caridad A Martinez; Stephen Gottschalk; Catherine M Bollard; Helen E Heslop; Malcolm K Brenner; Robert A Krance
The costs and cost-effectiveness of allogeneic peripheral blood stem cell transplantation versus bone marrow transplantation in pediatric patients with acute leukemia.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010;16(9):1272-81.
2010: Carlos A Ramos; Zahra Asgari; Enli Liu; Eric Yvon; Helen E Heslop; Cliona M Rooney; Malcolm K Brenner; Gianpietro Dotti
An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies.
Stem cells (Dayton, Ohio) 2010;28(6):1107-15.
2010: V Hoyos; Barbara Savoldo; Concetta Quintarelli; A Mahendravada; Ming Zhang; J Vera; Helen E Heslop; Cliona M Rooney; Malcolm K Brenner; Gianpietro Dotti
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety.
Leukemia 2010;24(6):1160-70.
2010: J A Shafer; Helen E Heslop; Malcolm K Brenner; G Carrum; M F Wu; H Liu; N Ahmed; S Gottschalk; R Kamble; K S Leung; G D Myers; C M Bollard; R A Krance
Outcome of hematopoietic stem cell transplant as salvage therapy for Hodgkin's lymphoma in adolescents and young adults at a single institution.
Leukemia & lymphoma 2010;51(4):664-70.
2010: Malcolm K Brenner; Helen E Heslop
Adoptive T cell therapy of cancer.
Current opinion in immunology 2010;22(2):251-7.
2010: Aaron E Foster; F V Okur; E Biagi; A Lu; Gianpietro Dotti; Eric Yvon; Barbara Savoldo; George Carrum; Margaret A Goodell; Helen E Heslop; Malcolm K Brenner
Selective elimination of a chemoresistant side population of B-CLL cells by cytotoxic T lymphocytes in subjects receiving an autologous hCD40L/IL-2 tumor vaccine.
Leukemia 2010;24(3):563-72.
2010: Helen E Heslop; Karen S Slobod; Martin A Pule; gregory alan hale; Alexandra Rousseau; Colton A Smith; Catherine M Bollard; Hao Liu; Meng-Fen Wu; Richard J Rochester; Persis J Amrolia; Julia L Hurwitz; Malcolm K Brenner; Cliona M Rooney
Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients.
Blood 2010;115(5):925-35.
2010: Fatma V Okur; Malcolm K Brenner
Cellular immunotherapy of cancer.
Methods in molecular biology (Clifton, N.J.) 2010;651():319-45.
2009: BIAGIO DE ANGELIS; Gianpietro Dotti; Concetta Quintarelli; Leslie E Huye; Lan Zhang; Ming Zhang; Fabrizio Pane; Helen E Heslop; Malcolm K Brenner; Cliona M Rooney; Barbara Savoldo
Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506).
Blood 2009;114(23):4784-91.
2009: Ann Leen; Anne Christin; G Douglas Myers; Hao Liu; Conrad R Cruz; Patrick J Hanley; Alana A Kennedy-Nasser; Kathryn S Leung; Adrian P Gee; Robert A Krance; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney; Catherine M Bollard
Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation.
Blood 2009;114(19):4283-92.
2009: Juan F Vera; Malcolm K Brenner; Gianpietro Dotti
Immunotherapy of human cancers using gene modified T lymphocytes.
Current gene therapy 2009;9(5):396-408.
2009: Eric Yvon; Michele Del Vecchio; Barbara Savoldo; Valentina Hoyos; Aurélie Dutour; Andrea Anichini; Gianpietro Dotti; Malcolm K Brenner
Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(18):5852-60.
2009: Ulrike Gerdemann; Anne S Christin; Juan F Vera; Carlos A Ramos; Yuriko Fujita; Hao Liu; Dagmar Dilloo; Helen E Heslop; Malcolm K Brenner; Cliona M Rooney; Ann Leen
Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(9):1616-25.
2009: Patrick J Hanley; Conrad Russell Young Cruz; Barbara Savoldo; Ann Leen; Maja Stanojevic; Mariam Khalil; William Decker; Jeffrey J Molldrem; Hao Liu; Adrian P Gee; Cliona M Rooney; Helen E Heslop; Gianpietro Dotti; Malcolm K Brenner; Elizabeth J Shpall; Catherine M Bollard
Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes.
Blood 2009;114(9):1958-67.
2009: Juan F Vera; Valentina Hoyos; Barbara Savoldo; Concetta Quintarelli; Greta M P Giordano Attianese; Ann Leen; Hao Liu; Aaron E Foster; Helen E Heslop; Cliona M Rooney; Malcolm K Brenner; Gianpietro Dotti
Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(5):880-8.
2009: Chrystal U Louis; Karin C Straathof; Catherine M Bollard; Claudia Gerken; M Helen Huls; Mary V Gresik; Meng-Fen Wu; Heidi L Weiss; Adrian P Gee; Malcolm K Brenner; Cliona M Rooney; Helen E Heslop; Stephen Gottschalk
Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients.
Blood 2009;113(11):2442-50.
2009: Malcolm K Brenner; Fatma V Okur
Overview of gene therapy clinical progress including cancer treatment with gene-modified T cells.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2009;():675-81.
2009: Aaron E Foster; Fatma V Okur; Ettore Biagi; An Lu; Gianpietro Dotti; Eric Yvon; Barbara Savoldo; George Carrum; Michael Andreeff; Margaret A Goodell; Helen E Heslop; Malcolm K Brenner
Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression.
Molecular cancer 2009;8():106.
2009: Chrystal U Louis; Malcolm K Brenner
Cellular immunotherapy for neuroblastoma: a review of current vaccine and adoptive T cell therapeutics.
Current pharmaceutical design 2009;15(4):424-9.
2008: Martin A Pule; Barbara Savoldo; G Douglas Myers; Claudia Rossig; Heidi V Russell; Gianpietro Dotti; M Helen Huls; Enli Liu; Adrian P Gee; Zhuyong Mei; Eric Yvon; Heidi L Weiss; Hao Liu; Cliona M Rooney; Helen E Heslop; Malcolm K Brenner
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma.
Nature medicine 2008;14(11):1264-70.
2008: Nabil Ahmed; Kathryn S Leung; Howard Rosenblatt; Catherine M Bollard; Stephen Gottschalk; G Douglas Myers; George Carrum; Helen E Heslop; Malcolm K Brenner; Robert A Krance
Successful treatment of stem cell graft failure in pediatric patients using a submyeloablative regimen of campath-1H and fludarabine.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008;14(11):1298-304.
2008: Alana A Kennedy-Nasser; Catherine M Bollard; G Douglas Myers; Kathryn S Leung; Stephen Gottschalk; Yiqun Zhang; Hao Liu; Helen E Heslop; Malcolm K Brenner; Robert A Krance
Comparable outcome of alternative donor and matched sibling donor hematopoietic stem cell transplant for children with acute lymphoblastic leukemia in first or second remission using alemtuzumab in a myeloablative conditioning regimen.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008;14(11):1245-52.
2008: Aaron E Foster; Malcolm K Brenner; Gianpietro Dotti
Adoptive T-cell immunotherapy of chronic lymphocytic leukaemia.
Best practice & research. Clinical haematology 2008;21(3):375-89.
2008: Helen E Heslop; Malcolm K Brenner
The clone ranger?
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(9):1520-1.
2008: Yuriko Fujita; Ann Leen; Jiali Sun; Yozo Nakazawa; Eric Yvon; Helen E Heslop; Malcolm K Brenner; Cliona M Rooney
Exploiting cytokine secretion to rapidly produce multivirus-specific T cells for adoptive immunotherapy.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2008;31(7):665-74.
2008: Aaron E Foster; Gianpietro Dotti; An Lu; Mariam Khalil; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney; Catherine M Bollard
Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2008;31(5):500-5.
2008: Hongsung Kim; Guangyong Peng; John M Hicks; Heidi L Weiss; Erwin Van Meir; Malcolm K Brenner; Patricia Yotnda
Engineering human tumor-specific cytotoxic T cells to function in a hypoxic environment.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):599-606.
2008: M A Pule; A Rousseau; J Vera; Helen E Heslop; Malcolm K Brenner; E F Vanin
Flanking-sequence exponential anchored-polymerase chain reaction amplification: a sensitive and highly specific method for detecting retroviral integrant-host-junction sequences.
Cytotherapy 2008;10(5):526-39.
2008: Malcolm K Brenner
Developing T-cell therapies for cancer in an academic setting.
Advances in experimental medicine and biology 2008;610():88-99.
2008: Ann Leen; Anne Christin; Mariam Khalil; Heidi Weiss; Adrian P Gee; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney; Catherine M Bollard
Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy.
Journal of virology 2008;82(1):546-54.
2007: Alana A Kennedy-Nasser; Malcolm K Brenner
T-cell therapy after hematopoietic stem cell transplantation.
Current opinion in hematology 2007;14(6):616-24.
2007: Concetta Quintarelli; Juan F Vera; Barbara Savoldo; Greta M P Giordano Attianese; Martin Pule; Aaron E Foster; Helen E Heslop; Cliona M Rooney; Malcolm K Brenner; Gianpietro Dotti
Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes.
Blood 2007;110(8):2793-802.
2007: Catherine M Bollard; Stephen Gottschalk; Ann Leen; Heidi Weiss; Karin C Straathof; George Carrum; Mariam Khalil; Meng-fen Wu; M Helen Huls; Chung-Che Chang; Mary V Gresik; Adrian P Gee; Malcolm K Brenner; Cliona M Rooney; Helen E Heslop
Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer.
Blood 2007;110(8):2838-45.
2007: H Wang; Guang Yang; Terry L Timme; T Fujita; Koji Naruishi; Anna Frolov; Malcolm K Brenner; Dov Kadmon; Timothy C Thompson
IL-12 gene-modified bone marrow cell therapy suppresses the development of experimental metastatic prostate cancer.
Cancer gene therapy 2007;14(10):819-27.
2007: Barbara Savoldo; Cliona M Rooney; Antonio Di Stasi; Hinrich Abken; Andreas Hombach; Aaron E Foster; Lan Zhang; Helen E Heslop; Malcolm K Brenner; Gianpietro Dotti
Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease.
Blood 2007;110(7):2620-30.
2007: Rammurti Kamble; D A Clark; H N Leong; Helen E Heslop; Malcolm K Brenner; George Carrum
Transmission of integrated human herpesvirus-6 in allogeneic hematopoietic stem cell transplantation.
Bone marrow transplantation 2007;40(6):563-6.
2007: Siok-Keen Tey; Gianpietro Dotti; Cliona M Rooney; Helen E Heslop; Malcolm K Brenner
Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(8):913-24.
2007: T Vu; George Carrum; George Hutton; Helen E Heslop; Malcolm K Brenner; Rammurti Kamble
Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation.
Bone marrow transplantation 2007;39(11):705-9.
2007: Siok-Keen Tey; Malcolm K Brenner
The continuing contribution of gene marking to cell and gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(4):666-76.
2007: Alan Davis; Francis H Gannon; Mustafa Ozen; Michael Ittmann; Zbigniew Gugala; John A Hipp; Kevin M Moran; Christine M Fouletier-Dilling; Shannon Schumara-Martin; Ronald W Lindsey; Michael H Heggeness; Malcolm K Brenner; Davis Alan
Hypoxic adipocytes pattern early heterotopic bone formation.
The American journal of pathology 2007;170(2):620-32.
2006: Alana A Kennedy-Nasser; Kathryn S Leung; Anita Mahajan; Heidi L Weiss; James A Arce; Stephen Gottschalk; George Carrum; Shakila P Khan; Helen E Heslop; Malcolm K Brenner; Catherine M Bollard; Robert A Krance
Comparable outcomes of matched-related and alternative donor stem cell transplantation for pediatric severe aplastic anemia.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(12):1277-84.
2006: Juan Vera; Barbara Savoldo; Stephane Vigouroux; Ettore Biagi; Martin Pule; Claudia Rossig; Jessie Wu; Helen E Heslop; Cliona M Rooney; Malcolm K Brenner; Gianpietro Dotti
T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells.
Blood 2006;108(12):3890-7.
2006: Barbara Savoldo; John A Goss; Markus M Hammer; Lan Zhang; Teresita Lopez; Adrian P Gee; Yu-Feng Lin; Ruben E Quiros-Tejeira; Petra Reinke; Stephan Schubert; Stephen Gottschalk; Milton J Finegold; Malcolm K Brenner; Cliona M Rooney; Helen E Heslop
Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs).
Blood 2006;108(9):2942-9.
2006: Ann Leen; G Douglas Myers; Uluhan Sili; M Helen Huls; Heidi Weiss; Kathryn S Leung; George Carrum; Robert A Krance; Chung-Che Chang; Jeffrey J Molldrem; Adrian P Gee; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney; Catherine M Bollard
Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.
Nature medicine 2006;12(10):1160-6.
2006: A Loskog; V Giandomenico; Claudia Rossig; Martin Pule; Gianpietro Dotti; Malcolm K Brenner
Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells.
Leukemia 2006;20(10):1819-28.
2006: Persis J Amrolia; Giada Muccioli-Casadei; Helen Huls; Stuart Adams; April Durett; Adrian Gee; Eric Yvon; Heidi Weiss; Mark Cobbold; H Bobby Gaspar; Cliona Rooney; Ingrid Kuehnle; Victor Ghetie; John Schindler; Robert A Krance; Helen E Heslop; Paul Veys; Ellen S Vitetta; Malcolm K Brenner
Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation.
Blood 2006;108(6):1797-808.
2006: Kristine Lacuesta; Elizabeth Buza; Hanns Hauser; Laura Granville; Martin Pule; Greg Corboy; Milton Finegold; Heidi Weiss; Si Y Chen; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney; Catherine M Bollard
Assessing the safety of cytotoxic T lymphocytes transduced with a dominant negative transforming growth factor-beta receptor.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2006;29(3):250-60.
2006: Uday Popat; Helen E Heslop; April Durett; Romelia May; Robert A Krance; Malcolm K Brenner; George Carrum
Outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation (RISCT) using antilymphocyte antibodies in patients with high-risk acute myeloid leukemia (AML).
Bone marrow transplantation 2006;37(6):547-52.
2006: Raphael Rousseau; Ettore Biagi; Aurélie Dutour; Eric Yvon; Michael P Brown; Tiffany Lin; Zhuyong Mei; Bambi Grilley; Edwina Popek; Helen E Heslop; Adrian P Gee; Robert A Krance; Uday Popat; George Carrum; Judith F Margolin; Malcolm K Brenner
Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation.
Blood 2006;107(4):1332-41.
2006: Stephen Gottschalk; Catherine M Bollard; Karin C Straathof; Chrystal U Louis; Barbara Savoldo; Gianpietro Dotti; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
T cell therapies.
Ernst Schering Foundation symposium proceedings 2006;(4):69-82.
2006: Catherine M Bollard; M Helen Huls; Elizabeth Buza; Heidi Weiss; Vicky Torrano; Mary V Gresik; Jeff Chang; Adrian Gee; Stephen Gottschalk; George Carrum; Malcolm K Brenner; Cliona M Rooney; Helen E Heslop
Administration of latent membrane protein 2-specific cytotoxic T lymphocytes to patients with relapsed Epstein-Barr virus-positive lymphoma.
Clinical lymphoma & myeloma 2006;6(4):342-7.
2006: Claudia Rossig; Annette Bär; Sibylle Pscherer; Bianca Altvater; Martin Pule; Cliona M Rooney; Malcolm K Brenner; Heribert Jürgens; Josef Vormoor
Target antigen expression on a professional antigen-presenting cell induces superior proliferative antitumor T-cell responses via chimeric T-cell receptors.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2006;29(1):21-31.
2005: R Lamba; George Carrum; G Douglas Myers; Catherine M Bollard; Robert A Krance; Helen E Heslop; Malcolm K Brenner; Uday Popat
Cytomegalovirus (CMV) infections and CMV-specific cellular immune reconstitution following reduced intensity conditioning allogeneic stem cell transplantation with Alemtuzumab.
Bone marrow transplantation 2005;36(9):797-802.
2005: Martin A Pulè; Karin C Straathof; Gianpietro Dotti; Helen E Heslop; Cliona M Rooney; Malcolm K Brenner
A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(5):933-41.
2005: Raphael Rousseau; Malcolm K Brenner
Vaccine therapies for pediatric malignancies.
Cancer journal (Sudbury, Mass.) 2005;11(4):331-9.
2005: Gianpietro Dotti; Barbara Savoldo; Martin Pule; Karin C Straathof; Ettore Biagi; Eric Yvon; Stephane Vigouroux; Malcolm K Brenner; Cliona M Rooney
Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis.
Blood 2005;105(12):4677-84.
2005: Uday Popat; George Carrum; Romelia May; R Lamba; Robert A Krance; Helen E Heslop; Malcolm K Brenner
CD52 and CD45 monoclonal antibodies for reduced intensity hemopoietic stem cell transplantation from HLA matched and one antigen mismatched unrelated donors.
Bone marrow transplantation 2005;35(12):1127-32.
2005: Karin C Straathof; Martin A Pulè; Patricia Yotnda; Gianpietro Dotti; Elio F Vanin; Malcolm K Brenner; Helen E Heslop; David M Spencer; Cliona M Rooney
An inducible caspase 9 safety switch for T-cell therapy.
Blood 2005;105(11):4247-54.
2005: Karin C Straathof; Catherine M Bollard; Uday Popat; M Helen Huls; Teresita Lopez; M Craig Morriss; Mary V Gresik; Adrian P Gee; Heidi V Russell; Malcolm K Brenner; Cliona M Rooney; Helen E Heslop
Treatment of nasopharyngeal carcinoma with Epstein-Barr virus--specific T lymphocytes.
Blood 2005;105(5):1898-904.
2005: Charlotte Hirschmann-Jax; Aaron E Foster; Gerald G Wulf; Margaret A Goodell; Malcolm K Brenner
A distinct "side population" of cells in human tumor cells: implications for tumor biology and therapy.
Cell cycle (Georgetown, Tex.) 2005;4(2):203-5.
2005: Persis J Amrolia; G Mucioli-Casadei; Helen Huls; Helen E Heslop; John Schindler; Paul Veys; Ellen S Vitetta; Malcolm K Brenner
Add-back of allodepleted donor T cells to improve immune reconstitution after haplo-identical stem cell transplantation.
Cytotherapy 2005;7(2):116-25.
2004: Catherine M Bollard; Laura K Aguilar; Karin C Straathof; Benedikt Gahn; M Helen Huls; Alexandra Rousseau; John Sixbey; Mary V Gresik; George Carrum; Melissa Hudson; Dagmar Dilloo; Adrian Gee; Malcolm K Brenner; Cliona M Rooney; Helen E Heslop
Cytotoxic T lymphocyte therapy for Epstein-Barr virus+ Hodgkin's disease.
The Journal of experimental medicine 2004;200(12):1623-33.
2004: Patricia Yotnda; C Zompeta; Helen E Heslop; Michael Andreeff; Malcolm K Brenner; Frank C Marini
Comparison of the efficiency of transduction of leukemic cells by fiber-modified adenoviruses.
Human gene therapy 2004;15(12):1229-42.
2004: Ann Leen; Uluhan Sili; Elio F Vanin; Alan M Jewell; WeiDong Xie; Dario Vignali; Pedro Piedra; Malcolm K Brenner; Cliona M Rooney
Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells.
Blood 2004;104(8):2432-40.
2004: Charlotte Hirschmann-Jax; Aaron E Foster; Gerald G Wulf; Jed Nuchtern; T W Jax; U Gobel; Margaret A Goodell; Malcolm K Brenner
A distinct "side population" of cells with high drug efflux capacity in human tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):14228-33.
2004: Catherine M Bollard; Karin C Straathof; M Helen Huls; Ann Leen; Kristine Lacuesta; Alan Davis; Stephen Gottschalk; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2004;27(4):317-27.
2004: Claudia Rossig; Malcolm K Brenner
Genetic modification of T lymphocytes for adoptive immunotherapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(1):5-18.
2004: Helen E Heslop; Stephen Gottschalk; Catherine M Bollard; Karin C Straathof; M Helen Huls; Malcolm K Brenner; Cliona M Rooney
Options for T-cell based therapies.
Vox sanguinis 2004;87 Suppl 2():230-4.
2004: Stephane Vigouroux; Eric Yvon; Ettore Biagi; Malcolm K Brenner
Antigen-induced regulatory T cells.
Blood 2004;104(1):26-33.
2004: Malcolm K Brenner
Haematopoietic stem cell transplantation for autoimmune disease: limits and future potential.
Best practice & research. Clinical haematology 2004;17(2):359-74.
2004: Hans-Joachim Wagner; Yee Chung Cheng; M Helen Huls; Adrian P Gee; Ingrid Kuehnle; Robert A Krance; Malcolm K Brenner; Cliona M Rooney; Helen E Heslop
Prompt versus preemptive intervention for EBV lymphoproliferative disease.
Blood 2004;103(10):3979-81.
2004: Patricia Yotnda; Davis Alan; M J Hicks; Nancy Smyth Templeton; Malcolm K Brenner; M K Benner
Liposomal enhancement of the antitumor activity of conditionally replication-competent adenoviral plasmids.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(4):489-95.
2004: Kevin Norwood; Rui-Yu Wang; Charlotte Hirschmann-Jax; Michael Andreeff; Malcolm K Brenner; Margaret A Goodell; Gerald G Wulf
An in vivo propagated human acute myeloid leukemia expressing ABCA3.
Leukemia research 2004;28(3):295-9.
2004: kui voo; Tihui Fu; Helen Y Wang; Ross Tellam; Helen E Heslop; Malcolm K Brenner; Cliona M Rooney; Rongfu Wang
Evidence for the presentation of major histocompatibility complex class I-restricted Epstein-Barr virus nuclear antigen 1 peptides to CD8+ T lymphocytes.
The Journal of experimental medicine 2004;199(4):459-70.
2004: Hans-Joachim Wagner; Catherine M Bollard; Stephane Vigouroux; M Helen Huls; Robert Anderson; H Grant Prentice; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
A strategy for treatment of Epstein-Barr virus-positive Hodgkin's disease by targeting interleukin 12 to the tumor environment using tumor antigen-specific T cells.
Cancer gene therapy 2004;11(2):81-91.
2004: Ann Leen; Uluhan Sili; Barbara Savoldo; Alan M Jewell; Pedro Piedra; Malcolm K Brenner; Cliona M Rooney
Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications.
Blood 2004;103(3):1011-9.
2003: Alan Davis; Zbigniew Gugala; Fernando D Camargo; Francis H Gannon; KathyJo Jackson; Kirsten A Kienstra; Harold Shine; Ronald W Lindsey; Karen K Hirschi; Margaret A Goodell; Malcolm K Brenner; Davis Alan
Primitive adult hematopoietic stem cells can function as osteoblast precursors.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15877-82.
2003: Eric Yvon; Stephane Vigouroux; Raphael Rousseau; Ettore Biagi; Persis J Amrolia; Gianpietro Dotti; Hans-Joachim Wagner; Malcolm K Brenner
Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells.
Blood 2003;102(10):3815-21.
2003: Stephane Vigouroux; Eric Yvon; Hans-Joachim Wagner; Ettore Biagi; Gianpietro Dotti; Uluhan Sili; Cecilia Lira; Cliona M Rooney; Malcolm K Brenner
Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes.
Journal of virology 2003;77(20):10872-80.
2003: Persis J Amrolia; Giada Muccioli-Casadei; Eric Yvon; Helen Huls; Uluhan Sili; Eric Wieder; Catherine M Bollard; Jaroslav Michalek; Victor Ghetie; Helen E Heslop; Jeffrey J Molldrem; Cliona M Rooney; John Schlinder; Ellen S Vitetta; Malcolm K Brenner
Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses.
Blood 2003;102(6):2292-9.
2003: Satoshi Takahashi; Hoyin Mok; Michael Brandon Parrott; Frank C Marini; Michael Andreeff; Malcolm K Brenner; Michael A Barry
Selection of chronic lymphocytic leukemia binding peptides.
Cancer research 2003;63(17):5213-7.
2003: Xinping Fu; Lihua Tao; Aiwu Jin; Richard Vile; Malcolm K Brenner; Xiaoliu Zhang
Expression of a fusogenic membrane glycoprotein by an oncolytic herpes simplex virus potentiates the viral antitumor effect.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(6):748-54.
2003: Uluhan Sili; M Helen Huls; Davis Alan; Stephen Gottschalk; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2003;26(3):241-56.
2003: Malcolm K Brenner; Gerald G Wulf; Donna R Rill; Kang-Li Luo; Margaret A Goodell; Zhuyong Mei; Ingrid Kuehnle; Michael P Brown; Martin Pule; Helen E Heslop; Robert A Krance
Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man.
Annals of the New York Academy of Sciences 2003;996():80-8.
2003: Ettore Biagi; Eric Yvon; Gianpietro Dotti; Persis J Amrolia; Satoshi Takahashi; Uday Popat; Frank C Marini; Michael Andreeff; Malcolm K Brenner; Raphael Rousseau
Bystander transfer of functional human CD40 ligand from gene-modified fibroblasts to B-chronic lymphocytic leukemia cells.
Human gene therapy 2003;14(6):545-59.
2003: Robert A Krance; Ingrid Kuehnle; Donna R Rill; Zhuyong Mei; Carl Pinetta; William Evans; Michael P Brown; Martin Pulé; Helen E Heslop; Malcolm K Brenner
Hematopoietic and immunomodulatory effects of lytic CD45 monoclonal antibodies in patients with hematologic malignancy.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2003;9(4):273-81.
2003: Gerald G Wulf; Kang-Li Luo; Kathyjo A Jackson; Malcolm K Brenner; Margaret A Goodell
Cells of the hepatic side population contribute to liver regeneration and can be replenished with bone marrow stem cells.
Haematologica 2003;88(4):368-78.
2003: Gerald G Wulf; Kang-Li Luo; Margaret A Goodell; Malcolm K Brenner
Anti-CD45-mediated cytoreduction to facilitate allogeneic stem cell transplantation.
Blood 2003;101(6):2434-9.
2003: Raphael Rousseau; Ann E Haight; Charlotte Hirschmann-Jax; Eric Yvon; Donna R Rill; Zhuyong Mei; Susan C Smith; Shannon Inman; Kristine Cooper; Pat Alcoser; Bambi Grilley; Adrian Gee; Edwina Popek; Andrew Davidoff; Laura C Bowman; Malcolm K Brenner; Douglas R Strother
Local and systemic effects of an allogeneic tumor cell vaccine combining transgenic human lymphotactin with interleukin-2 in patients with advanced or refractory neuroblastoma.
Blood 2003;101(5):1718-26.
2003: Persis J Amrolia; Steven D Reid; Liquan Gao; Beate Schultheis; Gianpietro Dotti; Malcolm K Brenner; Junia V Melo; John M Goldman; Hans J Stauss
Allorestricted cytotoxic T cells specific for human CD45 show potent antileukemic activity.
Blood 2003;101(3):1007-14.
2003: Malcolm K Brenner; Helen E Heslop
Is retroviral gene marking too dangerous to use?
Cytotherapy 2003;5(3):190-3.
2003: Hans-Joachim Wagner; Uluhan Sili; Benedikt Gahn; Stephane Vigouroux; M Helen Huls; WeiDong Xie; Dario A A Vignali; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
Expansion of EBV latent membrane protein 2a specific cytotoxic T cells for the adoptive immunotherapy of EBV latency type 2 malignancies: influence of recombinant IL12 and IL15.
Cytotherapy 2003;5(3):231-40.
2002: kui voo; Tihui Fu; Helen E Heslop; Malcolm K Brenner; Cliona M Rooney; Rongfu Wang
Identification of HLA-DP3-restricted peptides from EBNA1 recognized by CD4(+) T cells.
Cancer research 2002;62(24):7195-9.
2002: Barbara Savoldo; M Helen Huls; Zhensheng Liu; Takayuki Okamura; Hans-Dieter Volk; Petra Reinke; Robert Sabat; Nina Babel; James F Jones; Jennifer Webster-Cyriaque; Adrian P Gee; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection.
Blood 2002;100(12):4059-66.
2002: Ettore Biagi; Raphael Rousseau; Eric Yvon; Stephane Vigouroux; Gianpietro Dotti; Malcolm K Brenner
Cancer vaccines: dream, reality, or nightmare?
Clinical and experimental medicine 2002;2(3):109-18.
2002: Gianpietro Dotti; Barbara Savoldo; Patricia Yotnda; Donna R Rill; Malcolm K Brenner
Transgenic expression of CD40 ligand produces an in vivo antitumor immune response against both CD40(+) and CD40(-) plasmacytoma cells.
Blood 2002;100(1):200-7.
2002: Catherine M Bollard; Claudia Rössig; M Julia Calonge; M Helen Huls; Hans-Joachim Wagner; Joan Massague; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity.
Blood 2002;99(9):3179-87.
2002: Claudia Rossig; Catherine M Bollard; Jed Nuchtern; Cliona M Rooney; Malcolm K Brenner
Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy.
Blood 2002;99(6):2009-16.
2002: Patricia Yotnda; Dong-Hua Chen; Wah Chiu; Pedro Piedra; Alan Davis; Nancy Smyth Templeton; Malcolm K Brenner
Bilamellar cationic liposomes protect adenovectors from preexisting humoral immune responses.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(3):233-41.
2002: Jason M Shohet; M John Hicks; Sharon E Plon; Susan M Burlingame; Susan Stuart; Si-Yi Chen; Malcolm K Brenner; Jed Nuchtern
Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.
Cancer research 2002;62(4):1123-8.
2002: Barbara Savoldo; Michael L Cubbage; April Durett; John Goss; M Helen Huls; Zhensheng Liu; Lopez Teresita; Adrian P Gee; Paul D Ling; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
Generation of EBV-specific CD4+ cytotoxic T cells from virus naive individuals.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):909-18.
2002: Cliona M Rooney; Catherine M Bollard; M Helen Huls; Benedikt Gahn; Stephen Gottschalk; Hans-Joachim Wagner; R Anderson; H G Prentice; Malcolm K Brenner; Helen E Heslop
Immunotherapy for Hodgkin's disease.
Annals of hematology 2002;81 Suppl 2():S39-42.
2002: Helen E Heslop; Catherine M Bollard; Stephen Gottschalk; Ingrid Kuehnle; M Helen Huls; Adrian P Gee; Malcolm K Brenner; Cliona M Rooney
Immune therapy for EBV infections after hemopoietic stem-cell transplant.
Cytotherapy 2002;4(5):433-4.
2002: Zhensheng Liu; Barbara Savoldo; Helen Huls; Teresita Lopez; Adrian Gee; Jeffery Wilson; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the prevention and treatment of EBV-associated post-transplant lymphomas.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2002;159():123-33.
2001: Claudia Rossig; Catherine M Bollard; Jed Nuchtern; D A Merchant; Malcolm K Brenner
Targeting of G(D2)-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes.
International journal of cancer. Journal international du cancer 2001;94(2):228-36.
2001: Barbara Savoldo; John Goss; Zhensheng Liu; M Helen Huls; S Doster; Adrian P Gee; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
Generation of autologous Epstein-Barr virus-specific cytotoxic T cells for adoptive immunotherapy in solid organ transplant recipients.
Transplantation 2001;72(6):1078-86.
2001: Benedikt Gahn; Fernando Siller-Lopez; A D Pirooz; Eric Yvon; Stephen Gottschalk; R Longnecker; Malcolm K Brenner; Helen E Heslop; Estuardo Aguilar-Cordova; Cliona M Rooney
Adenoviral gene transfer into dendritic cells efficiently amplifies the immune response to LMP2A antigen: a potential treatment strategy for Epstein-Barr virus--positive Hodgkin's lymphoma.
International journal of cancer. Journal international du cancer 2001;93(5):706-13.
2001: Gerald G Wulf; Rui-Yu Wang; Ingrid Kuehnle; D Weidner; F Marini; Malcolm K Brenner; Michael Andreeff; Margaret A Goodell
A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia.
Blood 2001;98(4):1166-73.
2001: Raphael Rousseau; Charlotte Hirschmann-Jax; S Takahashi; Malcolm K Brenner
Cancer vaccines.
Hematology/oncology clinics of North America 2001;15(4):741-73.
2001: Satoshi Takahashi; Patricia Yotnda; Raphael Rousseau; Zhuyong Mei; S Smith; Donna R Rill; Anas Younes; Malcolm K Brenner
Transgenic expression of CD40L and interleukin-2 induces an autologous antitumor immune response in patients with non-Hodgkin's lymphoma.
Cancer gene therapy 2001;8(5):378-87.
2001: Satoshi Takahashi; Raphael Rousseau; Patricia Yotnda; Zhuyong Mei; Gianpietro Dotti; Donna R Rill; Richard L Hurwitz; Frank C Marini; Michael Andreeff; Malcolm K Brenner
Autologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and interleukin 2 transgenes.
Human gene therapy 2001;12(6):659-70.
2001: Malcolm K Brenner
Gene transfer and the treatment of haematological malignancy.
Journal of internal medicine 2001;249(4):345-58.
2001: Stephen Gottschalk; C Y Ng; M Perez; C A Smith; C Sample; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
An Epstein-Barr virus deletion mutant associated with fatal lymphoproliferative disease unresponsive to therapy with virus-specific CTLs.
Blood 2001;97(4):835-43.
2001: Cliona M Rooney; Laura K Aguilar; M Helen Huls; Malcolm K Brenner; Helen E Heslop
Adoptive immunotherapy of EBV-associated malignancies with EBV-specific cytotoxic T-cell lines.
Current topics in microbiology and immunology 2001;258():221-9.
2000: Claudia Rossig; Jed Nuchtern; Malcolm K Brenner
Selection of human antitumor single-chain Fv antibodies from the B-cell repertoire of patients immunized against autologous neuroblastoma.
Medical and pediatric oncology 2000;35(6):692-5.
2000: Malcolm K Brenner; Helen E Heslop; Robert A Krance; M Horowitz; Douglas R Strother; Jed Nuchtern; Bambi Grilley; E Martingano; K Cooper
Phase I study of chemokine and cytokine gene-modified autologous neuroblastoma cells for treatment of relapsed/refractory neuroblastoma using an adenoviral vector.
Human gene therapy 2000;11(10):1477-88.
2000: Ingrid Kuehnle; M Helen Huls; Zijuan Liu; M Semmelmann; Robert A Krance; Malcolm K Brenner; Cliona M Rooney; Helen E Heslop
CD20 monoclonal antibody (rituximab) for therapy of Epstein-Barr virus lymphoma after hemopoietic stem-cell transplantation.
Blood 2000;95(4):1502-5.
2000: Roland Schroers; I Sinha; Harry Segall; I G Schmidt-Wolf; Cliona M Rooney; Malcolm K Brenner; Richard E Sutton; Si-Yi Chen
Transduction of human PBMC-derived dendritic cells and macrophages by an HIV-1-based lentiviral vector system.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(2):171-9.
1999: Marie Roskrow; Dagmar Dilloo; N Suzuki; W Zhong; Cliona M Rooney; Malcolm K Brenner
Autoimmune disease induced by dendritic cell immunization against leukemia.
Leukemia research 1999;23(6):549-57.
1999: K Moriwaki; Richard E Sutton; M Perez; Malcolm K Brenner; Helen E Heslop
Transduction of CD34(+) and CD34(-)/lin(-) hemopoietic progenitors by lentivirus vectors.
Cytotherapy 1999;1(6):433-8.
1999: Helen E Heslop; M Perez; Ely Benaim; Richard J Rochester; Malcolm K Brenner; Cliona M Rooney
Transfer of EBV-specific CTL to prevent EBV lymphoma post bone marrow transplant.
Journal of clinical apheresis 1999;14(3):154-6.
1998: Cliona M Rooney; C A Smith; C Y Ng; S K Loftin; John W Sixbey; Y j Gan; D K Srivastava; Laura C Bowman; Robert A Krance; Malcolm K Brenner; Helen E Heslop
Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients.
Blood 1998;92(5):1549-55.
1998: M Hutchings; K Moriwaki; Dagmar Dilloo; T Hoffmann; S Kimbrough; Hans E Johnsen; Malcolm K Brenner; Helen E Heslop
Increased transduction efficiency of primary hematopoietic cells by physical colocalization of retrovirus and target cells.
Journal of hematotherapy 1998;7(3):217-24.
1998: Marie Roskrow; Cliona M Rooney; Helen E Heslop; Malcolm K Brenner; Robert A Krance; Mary V Gresik; Kenneth L McClain; Laura K Aguilar; Bambi Grilley; E Rob; George Carrum
Administration of neomycin resistance gene marked EBV specific cytotoxic T-lymphocytes to patients with relapsed EBV-positive Hodgkin disease.
Human gene therapy 1998;9(8):1237-50.
1998: Marie Roskrow; N Suzuki; Y j Gan; John W Sixbey; C Y Ng; S Kimbrough; M Hudson; Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the treatment of patients with EBV-positive relapsed Hodgkin's disease.
Blood 1998;91(8):2925-34.
1998: Cliona M Rooney; Marie Roskrow; N Suzuki; C Y Ng; Malcolm K Brenner; Helen E Heslop
Treatment of relapsed Hodgkin's disease using EBV-specific cytotoxic T cells.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9 Suppl 5():S129-32.
1998: Cliona M Rooney; Marie Roskrow; C A Smith; Malcolm K Brenner; Helen E Heslop
Immunotherapy for Epstein-Barr virus-associated cancers.
Journal of the National Cancer Institute. Monographs 1998;(23):89-93.
1998: Cliona M Rooney; Helen E Heslop; Malcolm K Brenner
EBV specific CTL: a model for immune therapy.
Vox sanguinis 1998;74 Suppl 2():497-8.
1998: Malcolm K Brenner; Helen E Heslop; Cliona M Rooney
Gene and cell transfer for specific immunotherapy.
Vox sanguinis 1998;74 Suppl 2():87-90.
1996: Karen S Slobod; T A Bennett; Pamela J Freiden; A M Kechli; N Howlett; P M Flynn; D R Head; D K Srivastava; J M Boyett; Malcolm K Brenner; Jose Garcia-Martinez
Mobilization of CD34+ progenitor cells by granulocyte colony-stimulating factor in human immunodeficiency virus type 1-infected adults.
Blood 1996;88(9):3329-35.
1996: C A Smith; C Y Ng; S K Loftin; C Li; Helen E Heslop; Malcolm K Brenner; Cliona M Rooney
Adoptive immunotherapy for Epstein-Barr virus-related lymphoma.
Leukemia & lymphoma 1996;23(3-4):213-20.
1996: Dagmar Dilloo; Donna R Rill; M E Grossmann; Thasia Leimig; Malcolm K Brenner
Gene marking and gene therapy for transplantation medicine.
Journal of hematotherapy 1996;5(5):553-5.
1996: Malcolm K Brenner; Helen E Heslop; Donna R Rill; C Li; C Smith; Robert A Krance; Cliona M Rooney
Transfer of marker genes into hemopoietic progenitor cells.
Cytokines and molecular therapy 1996;2(3):193-200.
1996: Helen E Heslop; C Y Ng; C Li; C A Smith; S K Loftin; Robert A Krance; Malcolm K Brenner; Cliona M Rooney
Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes.
Nature medicine 1996;2(5):551-5.
1996: Helen E Heslop; Malcolm K Brenner; Robert A Krance; L Bowman; J M Cunningham; S Richardson; B Alexander; R Heideman; James M Boyett; D K Srivastava; S G Marcus; R Berenson; S Heimfeld; S Brown
Use of double marking with retroviral vectors to determine rate of reconstitution of untreated and cytokine expanded CD34+ selected marrow cells in patients undergoing autologous bone marrow transplantation.
Human gene therapy 1996;7(5):655-67.
1996: M E Cela; M S Holladay; Cliona M Rooney; S Richardson; B Alexander; Robert A Krance; Malcolm K Brenner; Helen E Heslop
Gamma delta T lymphocyte regeneration after T lymphocyte-depleted bone marrow transplantation from mismatched family members or matched unrelated donors.
Bone marrow transplantation 1996;17(2):243-7.
1996: Helen E Heslop; Cliona M Rooney; Donna R Rill; Robert A Krance; Malcolm K Brenner
Use of gene marking in bone marrow transplantation.
Cancer detection and prevention 1996;20(2):108-13.
1995: Helen E Heslop; Cliona M Rooney; Malcolm K Brenner
Gene-marking and haemopoietic stem-cell transplantation.
Blood reviews 1995;9(4):220-5.
1995: Malcolm K Brenner
Autologous bone-marrow transplantation in childhood acute lymphoblastic leukaemia.
Lancet 1995;346(8979):856-7.
1995: Helen E Heslop; Ely Benaim; Malcolm K Brenner; Robert A Krance; L M Stricklin; R J Rochester; R Billing
Response of steroid-resistant graft-versus-host disease to lymphoblast antibody CBL1.
Lancet 1995;346(8978):805-6.
1995: C A Smith; C Y Ng; Helen E Heslop; M S Holladay; S Richardson; E V Turner; S K Loftin; C Li; Malcolm K Brenner; Cliona M Rooney
Production of genetically modified Epstein-Barr virus-specific cytotoxic T cells for adoptive transfer to patients at high risk of EBV-associated lymphoproliferative disease.
Journal of hematotherapy 1995;4(2):73-9.
1995: Malcolm K Brenner
The use of cytokines to improve gene transfer to human hematopoietic stem cells.
Cytokines and molecular therapy 1995;1(1):3-9.
1995: Cliona M Rooney; C A Smith; C Y Ng; S Loftin; C Li; Robert A Krance; Malcolm K Brenner; Helen E Heslop
Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation.
Lancet 1995;345(8941):9-13.
1995: Cliona M Rooney; S K Loftin; M S Holladay; Malcolm K Brenner; Robert A Krance; Helen E Heslop
Early identification of Epstein-Barr virus-associated post-transplantation lymphoproliferative disease.
British journal of haematology 1995;89(1):98-103.
1994: Donna R Rill; Victor M Santana; W M Roberts; T Nilson; Laura C Bowman; Robert A Krance; Helen E Heslop; R C Moen; J N Ihle; Malcolm K Brenner
Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells.
Blood 1994;84(2):380-3.
1994: Malcolm K Brenner; Donna R Rill; R C Moen; Robert A Krance; Helen E Heslop; J Mirro; W F Anderson; J N Ihle
Gene marking and autologous bone marrow transplantation.
Annals of the New York Academy of Sciences 1994;716():204-14; discussion 214-5, 225-7.
1994: M Koehler; C A Hurwitz; Robert A Krance; Elaine Coustan-Smith; L L Williams; Victor M Santana; Raul C Ribeiro; Malcolm K Brenner; Helen E Heslop
XomaZyme-CD5 immunotoxin in conjunction with partial T cell depletion for prevention of graft rejection and graft-versus-host disease after bone marrow transplantation from matched unrelated donors.
Bone marrow transplantation 1994;13(5):571-5.
1994: Helen E Heslop; Malcolm K Brenner; Cliona M Rooney; Robert A Krance; W M Roberts; R Rochester; C A Smith; V Turner; John W Sixbey; R Moen
Administration of neomycin-resistance-gene-marked EBV-specific cytotoxic T lymphocytes to recipients of mismatched-related or phenotypically similar unrelated donor marrow grafts.
Human gene therapy 1994;5(3):381-97.
1994: P Mathew; P Bozeman; Robert A Krance; Malcolm K Brenner; Helen E Heslop
Bronchiolitis obliterans organizing pneumonia (BOOP) in children after allogeneic bone marrow transplantation.
Bone marrow transplantation 1994;13(2):221-3.
1994: Malcolm K Brenner; Donna R Rill
Gene marking to improve the outcome of autologous bone marrow transplantation.
Journal of hematotherapy 1994;3(1):33-6.
1994: Malcolm K Brenner; Donna R Rill
Gene marking to improve the outcome of autologous bone marrow transplantation.
Progress in clinical and biological research 1994;389():587-91.
1994: Malcolm K Brenner; Donna R Rill; Helen E Heslop; Cliona M Rooney; W M Roberts; C Li; T Nilson; Robert A Krance
Gene marking after bone marrow transplantation.
European journal of cancer (Oxford, England : 1990) 1994;30A(8):1171-6.
1994: Malcolm K Brenner; Helen E Heslop; Donna R Rill; C Li; T Nilson; M Roberts; C Smith; Robert A Krance; Cliona M Rooney
Gene transfer and bone marrow transplantation.
Cold Spring Harbor symposia on quantitative biology 1994;59():691-7.
1993: Malcolm K Brenner; Donna R Rill; M S Holladay; Helen E Heslop; R C Moen; M Buschle; Robert A Krance; Victor M Santana; W F Anderson; J N Ihle
Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients.
Lancet 1993;342(8880):1134-7.
1993: L L Williams; Cliona M Rooney; M E Conley; Malcolm K Brenner; Robert A Krance; Helen E Heslop
Correction of Duncan's syndrome by allogeneic bone marrow transplantation.
Lancet 1993;342(8871):587-8.
1993: N K Foreman; Donna R Rill; E Coustan-Smith; E C Douglass; Malcolm K Brenner
Mechanisms of selective killing of neuroblastoma cells by natural killer cells and lymphokine activated killer cells. Potential for residual disease eradication.
British journal of cancer 1993;67(5):933-8.
1993: Malcolm K Brenner; Donna R Rill; R C Moen; Robert A Krance; J Mirro; W F Anderson; J N Ihle
Gene-marking to trace origin of relapse after autologous bone-marrow transplantation.
Lancet 1993;341(8837):85-6.
1993: Robert A Krance; Helen E Heslop; Hazem H Mahmoud; R Ribeiro; E Douglass; C Hurwitz; Victor M Santana; L Kun; M M Horowitz; Malcolm K Brenner
Anti-pan T lymphocyte ricin A chain immunotoxin (H65-RTA) and methylprednisolone for acute GVHD prophylaxis following allogeneic BMT from HLA-identical sibling donors.
Bone marrow transplantation 1993;11(1):33-6.
1993: M Buschle; Dario Campana; S R Carding; C Richard; A V Hoffbrand; Malcolm K Brenner
Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia.
The Journal of experimental medicine 1993;177(1):213-8.
1993: Malcolm K Brenner
Gene transfer into human hematopoietic progenitor cells: a review of current clinical protocols.
Journal of hematotherapy 1993;2(1):7-17.
1992: Victor M Santana; Michael J Schell; R Williams; Laura C Bowman; Elizabeth Thompson; Malcolm K Brenner; J Mirro
Escalating sequential high-dose carboplatin and etoposide with autologous marrow support in children with relapsed solid tumors.
Bone marrow transplantation 1992;10(5):457-62.
1992: Donna R Rill; R C Moen; M Buschle; C Bartholomew; N K Foreman; J Mirro; Robert A Krance; J N Ihle; Malcolm K Brenner
An approach for the analysis of relapse and marrow reconstitution after autologous marrow transplantation using retrovirus-mediated gene transfer.
Blood 1992;79(10):2694-700.
1992: Donna R Rill; M Buschle; N K Foreman; C Bartholomew; R C Moen; Victor M Santana; J N Ihle; Malcolm K Brenner
Retrovirus-mediated gene transfer as an approach to analyze neuroblastoma relapse after autologous bone marrow transplantation.
Human gene therapy 1992;3(2):129-36.
1991: Helen E Heslop; Malcolm K Brenner; K Ganeshaguru; A V Hoffbrand
Possible mechanism of action of interferon alpha in chronic B-cell malignancies.
British journal of haematology 1991;79 Suppl 1():14-6.
1991: Malcolm K Brenner
Interleukin 2 and the treatment of leukemia and lymphoma.
Leukemia & lymphoma 1991;5(2-3):77-83.