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Kenneth Wu

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Chemicals & Drugs

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Hong C Shen; Fa-Xiang Ding; Subharekha Raghavan; Qiaolin Deng; Silvi Luell; Michael J Forrest; Ester Carballo-Jane; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Qing Chen; Junying Wang; Michael S Wolff; Xinchun Tong; Tom G Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
Hong Shen; Fa-Xiang Ding; Qiaolin Deng; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Ester Carballo-Jane; Ning Ren; Tian-Quan Cai; Tsuei-Ju Wu; Kenneth K Wu; Kang Cheng; Qing Chen; Michael S Wolff; Xinchun Tong; Tom Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
Hong Shen; Michael J Szymonifka; Divya Kharbanda; Qiaolin Deng; Ester Carballo-Jane; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Andrew K P Taggart; Junying Wang; Xinchun Tong; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.

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All Publications

2010: Hong C Shen; Fa-Xiang Ding; Subharekha Raghavan; Qiaolin Deng; Silvi Luell; Michael J Forrest; Ester Carballo-Jane; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Qing Chen; Junying Wang; Michael S Wolff; Xinchun Tong; Tom G Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
Journal of medicinal chemistry 2010;53(6):2666-70.
2009: Hong Shen; Fa-Xiang Ding; Qiaolin Deng; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Ester Carballo-Jane; Ning Ren; Tian-Quan Cai; Tsuei-Ju Wu; Kenneth K Wu; Kang Cheng; Qing Chen; Michael S Wolff; Xinchun Tong; Tom Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
Journal of medicinal chemistry 2009;52(8):2587-602.
2007: Hong Shen; Michael J Szymonifka; Divya Kharbanda; Qiaolin Deng; Ester Carballo-Jane; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Andrew K P Taggart; Junying Wang; Xinchun Tong; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.
Bioorganic & medicinal chemistry letters 2007;17(24):6723-8.
2007: Hong Shen; Fa-Xiang Ding; Silvi Luell; Michael J Forrest; Ester Carballo-Jane; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K Taggart; Ning Ren; Tian-Quan Cai; Qiaolin Deng; Qing Chen; Junying Wang; Michael S Wolff; Xinchun Tong; Tom Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
Journal of medicinal chemistry 2007;50(25):6303-6.
2006: Kang Cheng; Tsuei-Ju Wu; Kenneth K Wu; Claudio Sturino; Kathleen M Metters; Keith M Gottesdiener; Samuel D Wright; Zhaoyin Wang; Gary O'Neill; Eseng Lai; M Gerard Waters
Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6682-7.
2005: Kenneth K Wu; Tsuei-Ju Wu; Jayne Chin; Lyndon J Mitnaul; Melba Hernandez; Tian-Quan Cai; Ning Ren; M Gerard Waters; Samuel D Wright; Kang Cheng
Increased hypercholesterolemia and atherosclerosis in mice lacking both ApoE and leptin receptor.
Atherosclerosis 2005;181(2):251-9.