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Lingyun Wu

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Guangdong Yang; Kexin Zhao; Lingyun Wu; Qiuhui Cao; Youngjun Ju; Neelam Khaper; Sarathi Mani; Stephanie Puukila; Rui Wang
Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2.
Jianghai Liu; Rui Wang; Kaushik Desai; Lingyun Wu
Up-regulation of aldolase A and methylglyoxal production in adipocytes.
G Tang; Lingyun Wu; G Yang; L Zhang; Rui Wang
Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells.

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2013: Guangdong Yang; Kexin Zhao; Lingyun Wu; Qiuhui Cao; Youngjun Ju; Neelam Khaper; Sarathi Mani; Stephanie Puukila; Rui Wang
Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2.
Antioxidants & redox signaling 2013;18(15):1906-19.
2013: Jianghai Liu; Rui Wang; Kaushik Desai; Lingyun Wu
Up-regulation of aldolase A and methylglyoxal production in adipocytes.
British journal of pharmacology 2013;168(7):1639-46.
2013: G Tang; Lingyun Wu; G Yang; L Zhang; Rui Wang
Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells.
Diabetologia 2013;56(3):533-41.
2013: Ling Zhang; Youngjun Ju; Ashley Untereiner; Lingyun Wu; Guangdong Yang; Rui Wang
Hydrogen sulfide impairs glucose utilization and increases gluconeogenesis in hepatocytes.
Endocrinology 2013;154(1):114-26.
2012: Bo Wu; Lingyun Wu; Guangdong Yang; Huajian Teng; Rui Wang
Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α.
British journal of pharmacology 2012;167(7):1492-505.
2012: Yang Su; Lingyun Wu; Xi Lei; Lixin Liu
The role of endothelial cell adhesion molecules P-selectin, E-selectin and intercellular adhesion molecule-1 in leucocyte recruitment induced by exogenous methylglyoxal.
Immunology 2012;137(1):65-79.
2012: Indu Dhar; Lingyun Wu; Arti Dhar; Kaushik Desai
Arginine attenuates methylglyoxal- and high glucose-induced endothelial dysfunction and oxidative stress by an endothelial nitric-oxide synthase-independent mechanism.
The Journal of pharmacology and experimental therapeutics 2012;342(1):196-204.
2012: Guangdong Yang; Kexin Zhao; Lingyun Wu; Changqing Xu; Qiuhui Cao; Hongzhu Li; Guanghua Tang; Rui Wang
Increased neointimal formation in cystathionine gamma-lyase deficient mice: role of hydrogen sulfide in α5β1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells.
Journal of molecular and cellular cardiology 2012;52(3):677-88.
2012: Ming Fu; Hongzhu Li; Lingyun Wu; Guangdong Yang; Weihua Zhang; Rui Wang
Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):2943-8.
2012: Gamarallage V K Senanayake; Lingyun Wu; Ali Banigesh; Paul Lee; Bernhard H J Juurlink
The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats.
American journal of hypertension 2012;25(2):229-35.
2012: Jianghai Liu; Timothy Chun-Ping Mak; Rui Wang; Ali Banigesh; Kaushik Desai; Lingyun Wu
Aldolase B knockdown prevents high glucose-induced methylglyoxal overproduction and cellular dysfunction in endothelial cells.
PloS one 2012;7(7):e41495.
2012: Hongzhu Li; Sarathi Mani; Wei Cao; Christopher Lai; Lingyun Wu; Guangdong Yang; Rui Wang
Interaction of hydrogen sulfide and estrogen on the proliferation of vascular smooth muscle cells.
PloS one 2012;7(8):e41614.
2012: Xuming Jia; Thomas W Wilson; Tuanjie Chang; Lingyun Wu
Methylglyoxal mediates adipocyte proliferation by increasing phosphorylation of Akt1.
PloS one 2012;7(5):e36610.
2011: Yanxi Pei; Bo Wu; Lingyun Wu; Qiuhui Cao; Guangdong Yang
Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells.
Toxicology and applied pharmacology 2011;257(3):420-8.
2011: Jianghai Liu; Rui Wang; Kaushik Desai; Lingyun Wu
Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome.
Cardiovascular research 2011;92(3):494-503.
2011: Tuanjie Chang; Rui Wang; Douglas J H Olson; Darrell D Mousseau; Andrew R S Ross; Lingyun Wu
Modification of Akt1 by methylglyoxal promotes the proliferation of vascular smooth muscle cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(5):1746-57.
2011: Arti Dhar; Indu Dhar; Bo Jiang; Kaushik M Desai; Lingyun Wu
Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats.
Diabetes 2011;60(3):899-908.
2011: Kaushik M Desai; Ashley Untereiner; Tuanjie Chang; Lingyun Wu
Hydrogen sulfide and the metabolic syndrome.
Expert review of clinical pharmacology 2011;4(1):63-73.
2010: Arti Dhar; Indu Dhar; Kaushik M Desai; Lingyun Wu
Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose.
British journal of pharmacology 2010;161(8):1843-56.
2010: Guanghua Tang; Lingyun Wu; Rui Wang
Interaction of hydrogen sulfide with ion channels.
Clinical and experimental pharmacology & physiology 2010;37(7):753-63.
2010: Guangdong Yang; Lingyun Wu; Sean Bryan; Neelam Khaper; Sarathi Mani; Rui Wang
Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells.
Cardiovascular research 2010;86(3):487-95.
2010: Tuanjie Chang; Ashley Untereiner; Jianghai Liu; Lingyun Wu
Interaction of methylglyoxal and hydrogen sulfide in rat vascular smooth muscle cells.
Antioxidants & redox signaling 2010;12(9):1093-100.
2010: Kaushik M Desai; Tuanjie Chang; Hui Wang; Ali Banigesh; Arti Dhar; Jianghai Liu; Ashley Untereiner; Lingyun Wu
Oxidative stress and aging: is methylglyoxal the hidden enemy?
Canadian journal of physiology and pharmacology 2010;88(3):273-84.
2010: Arti Dhar; Kaushik M Desai; Lingyun Wu
Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats.
British journal of pharmacology 2010;159(1):166-75.
2009: Hui Wang; Jianghai Liu; Lingyun Wu
Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells.
Biochemical pharmacology 2009;77(11):1709-16.
2009: Arti Dhar; Kaushik Desai; Jianghai Liu; Lingyun Wu
Methylglyoxal, protein binding and biological samples: are we getting the true measure?
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(11-12):1093-100.
2009: Lingyun Wu; Wei Yang; Xuming Jia; Guangdong Yang; Dessislava Duridanova; Kun Cao; Rui Wang
Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats.
Laboratory investigation; a journal of technical methods and pathology 2009;89(1):59-67.
2008: Mei-Ping Lu; Rui Wang; Xiuyuan Song; Xiaoxia Wang; Lingyun Wu; Qing H Meng
Modulation of methylglyoxal and glutathione by soybean isoflavones in mild streptozotocin-induced diabetic rats.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2008;18(9):618-23.
2008: Guangdong Yang; Lingyun Wu; Bo Jiang; Wei Yang; Jiansong Qi; Kun Cao; Qinghe Meng; Asif K Mustafa; Weitong Mu; Shengming Zhang; Solomon H Snyder; Rui Wang
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.
Science (New York, N.Y.) 2008;322(5901):587-90.
2008: Arti Dhar; Kaushik Desai; Michael Kazachmov; Peter Yu; Lingyun Wu
Methylglyoxal production in vascular smooth muscle cells from different metabolic precursors.
Metabolism: clinical and experimental 2008;57(9):1211-20.
2008: Xiaoxia Wang; Xuming Jia; Tuanjie Chang; Kaushik Desai; Lingyun Wu
Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats.
Journal of hypertension 2008;26(4):765-72.
2008: Kaushik M Desai; Lingyun Wu
Free radical generation by methylglyoxal in tissues.
Drug metabolism and drug interactions 2008;23(1-2):151-73.
2007: Bo Jiang; Lingyun Wu; Rui Wang
Sulphonylureas induced vasorelaxation of mouse arteries.
European journal of pharmacology 2007;577(1-3):124-8.
2007: Xuming Jia; Lingyun Wu
Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats.
Molecular and cellular biochemistry 2007;306(1-2):133-9.
2007: Hui Wang; Qing H Meng; John R. Gordon; Hasnain M Khandwala; Lingyun Wu
Proinflammatory and proapoptotic effects of methylglyoxal on neutrophils from patients with type 2 diabetes mellitus.
Clinical biochemistry 2007;40(16-17):1232-9.
2007: Kaushik Desai; Lingyun Wu
Methylglyoxal and advanced glycation endproducts: new therapeutic horizons?
Recent patents on cardiovascular drug discovery 2007;2(2):89-99.
2007: Xiaoxia Wang; Tuanjie Chang; Bo Jiang; Kaushik Desai; Lingyun Wu
Attenuation of hypertension development by aminoguanidine in spontaneously hypertensive rats: role of methylglyoxal.
American journal of hypertension 2007;20(6):629-36.
2007: Guangdong Yang; Wei Yang; Lingyun Wu; Rui Wang
H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells.
The Journal of biological chemistry 2007;282(22):16567-76.
2007: Qing H Meng; Guangdong Yang; Wei Yang; Bo Jiang; Lingyun Wu; Rui Wang
Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries.
The American journal of pathology 2007;170(4):1406-14.
2006: Sheng-kai Yan; Tuanjie Chang; Hui Wang; Lingyun Wu; Rui Wang; Qing H Meng
Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cells.
Biochemical and biophysical research communications 2006;351(2):485-91.
2006: Tuanjie Chang; Lingyun Wu
Methylglyoxal, oxidative stress, and hypertension.
Canadian journal of physiology and pharmacology 2006;84(12):1229-38.
2006: Hui Wang; Qing H Meng; Tuanjie Chang; Lingyun Wu
Fructose-induced peroxynitrite production is mediated by methylglyoxal in vascular smooth muscle cells.
Life sciences 2006;79(26):2448-54.
2006: Rui Wang; Rany Shamloul; Xiaoxia Wang; Qinghe Meng; Lingyun Wu
Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump.
Hypertension 2006;48(4):685-92.
2006: Tuanjie Chang; Lingyun Wu; Rui Wang
Altered expression of BK channel beta1 subunit in vascular tissues from spontaneously hypertensive rats.
American journal of hypertension 2006;19(7):678-85.
2006: Xuming Jia; Douglas J H Olson; Andrew R S Ross; Lingyun Wu
Structural and functional changes in human insulin induced by methylglyoxal.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1555-7.
2006: Guangdong Yang; Lingyun Wu; Rui Wang
Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):553-5.
2006: Mohammad Hossein Noyan Ashraf; Lingyun Wu; Rui Wang; Bernhard H J Juurlink
Dietary approaches to positively influence fetal determinants of adult health.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(2):371-3.
2006: Y Huang; Lingyun Wu; C Xu; B Yang; Rui Wang
Increased HO-1 expression and decreased iNOS expression in the hippocampus from adult spontaneously hypertensive rats.
Cell biochemistry and biophysics 2006;46(1):35-42.
2006: Lingyun Wu
Is methylglyoxal a causative factor for hypertension development?
Canadian journal of physiology and pharmacology 2006;84(1):129-39.
2006: Xiaoxia Wang; Kaushik Desai; Bernhard H J Juurlink; J de Champlain; Lingyun Wu
Gender-related differences in advanced glycation endproducts, oxidative stress markers and nitric oxide synthases in rats.
Kidney international 2006;69(2):281-7.
2005: Lingyun Wu; Rui Wang
Carbon monoxide: endogenous production, physiological functions, and pharmacological applications.
Pharmacological reviews 2005;57(4):585-630.
2005: Wei Yang; Guangdong Yang; Xuming Jia; Lingyun Wu; Rui Wang
Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms.
The Journal of physiology 2005;569(Pt 2):519-31.
2005: Guanghua Tang; Lingyun Wu; Wenbin Liang; Rui Wang
Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells.
Molecular pharmacology 2005;68(6):1757-64.
2005: Xiaoxia Wang; Kaushik Desai; Tuanjie Chang; Lingyun Wu
Vascular methylglyoxal metabolism and the development of hypertension.
Journal of hypertension 2005;23(8):1565-73.
2005: Guanghua Tang; Lingyun Wu; Rui Wang
The effect of hydroxylamine on KATP channels in vascular smooth muscle and underlying mechanisms.
Molecular pharmacology 2005;67(5):1723-31.
2005: Tuanjie Chang; Rui Wang; Lingyun Wu
Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells.
Free radical biology & medicine 2005;38(2):286-93.
2005: Lingyun Wu
The pro-oxidant role of methylglyoxal in mesenteric artery smooth muscle cells.
Canadian journal of physiology and pharmacology 2005;83(1):63-8.
2004: Xiaoxia Wang; Kaushik Desai; Jes Thorn Clausen; Lingyun Wu
Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats.
Kidney international 2004;66(6):2315-21.
2004: Guangdong Yang; Kun Cao; Lingyun Wu; Rui Wang
Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1.
The Journal of biological chemistry 2004;279(47):49199-205.
2004: Lingyun Wu; Rui Wang; Jacques De Champlain; Thomas W Wilson
Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats.
American journal of hypertension 2004;17(9):749-56.
2004: Lingyun Wu; Mohammad Hossein Noyan Ashraf; Marina Facci; Rui Wang; Phyllis G Paterson; Alison Ferrie; Bernhard H J Juurlink
Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7094-9.
2003: Rui Wang; Changqing Xu; Weimin Zhao; Jing Zhang; Kun Cao; Baofeng Yang; Lingyun Wu
Calcium and polyamine regulated calcium-sensing receptors in cardiac tissues.
European journal of biochemistry / FEBS 2003;270(12):2680-8.
2003: Joseph Fomusi Ndisang; Lingyun Wu; Weimin Zhao; Rui Wang
Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats.
Blood 2003;101(10):3893-900.
2003: Rui Wang; Lingyun Wu
Interaction of selective amino acid residues of K(ca) channels with carbon monoxide.
Experimental biology and medicine (Maywood, N.J.) 2003;228(5):474-80.
2002: Lingyun Wu; Kun Cao; Yanjie Lu; Rui Wang
Different mechanisms underlying the stimulation of K(Ca) channels by nitric oxide and carbon monoxide.
The Journal of clinical investigation 2002;110(5):691-700.
2002: Lingyun Wu; Bernhard H J Juurlink
Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells.
Hypertension 2002;39(3):809-14.
2002: Lingyun Wu; Gerald F Davies; William J Roesler; Bernhard H J Juurlink
Regulation of the glyoxalase pathway in human brain microvascular endothelium: effects of troglitazone and tertiary butylhydroperoxide.
Endothelium : journal of endothelial cell research 2002;9(4):273-8.
2001: Lingyun Wu; E Eftekharpour; Gerald F Davies; William J Roesler; Bernhard H J Juurlink
Troglitazone selectively inhibits glyoxalase I gene expression.
Diabetologia 2001;44(11):2004-12.
2001: Gerald F Davies; Ramji L Khandelwal; Lingyun Wu; Bernhard H J Juurlink; William J Roesler
Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism.
Biochemical pharmacology 2001;62(8):1071-9.
2001: Lingyun Wu; Bernhard H J Juurlink
The impaired glutathione system and its up-regulation by sulforaphane in vascular smooth muscle cells from spontaneously hypertensive rats.
Journal of hypertension 2001;19(10):1819-25.
2001: Rui Wang; Z Wang; Lingyun Wu; Salma Toma Hanna; R Peterson-Wakeman
Reduced vasorelaxant effect of carbon monoxide in diabetes and the underlying mechanisms.
Diabetes 2001;50(1):166-74.
2000: Lingyun Wu; Z Wang; Rui Wang
Tetraethylammonium-evoked oscillatory contractions of rat tail artery: a K-K model.
Canadian journal of physiology and pharmacology 2000;78(9):696-707.
2000: Rui Wang; Y Wu; Guanghua Tang; Lingyun Wu; Salma Toma Hanna
Altered L-type Ca(2+) channel currents in vascular smooth muscle cells from experimental diabetic rats.
American journal of physiology. Heart and circulatory physiology 2000;278(3):H714-22.
1998: Z Wang; Lingyun Wu; Rui Wang
Kinin B2 receptor-mediated contraction of tail arteries from normal or streptozotocin-induced diabetic rats.
British journal of pharmacology 1998;125(1):143-51.