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Li Wu

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TOP 3
Mazdak Khajehpour; Li Wu; Sijiu Liu; Nick Zhadin; Zhong-Yin Zhang; Robert Callender
Loop dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase.
Daniel F McCain; Piotr K Grzyska; Li Wu; Alvan C Hengge; Zhong-Yin Zhang
Mechanistic studies of protein tyrosine phosphatases YopH and Cdc25A with m-nitrobenzyl phosphate.
Daniel F McCain; Li Wu; Peter Nickel; Matthias U Kassack; Annett Kreimeyer; Antonio Gagliardi; Delwood C Collins; Zhong-Yin Zhang
Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases.

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All Publications

2007: Mazdak Khajehpour; Li Wu; Sijiu Liu; Nick Zhadin; Zhong-Yin Zhang; Robert Callender
Loop dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase.
Biochemistry 2007;46(14):4370-8.
2004: Daniel F McCain; Piotr K Grzyska; Li Wu; Alvan C Hengge; Zhong-Yin Zhang
Mechanistic studies of protein tyrosine phosphatases YopH and Cdc25A with m-nitrobenzyl phosphate.
Biochemistry 2004;43(25):8256-64.
2004: Daniel F McCain; Li Wu; Peter Nickel; Matthias U Kassack; Annett Kreimeyer; Antonio Gagliardi; Delwood C Collins; Zhong-Yin Zhang
Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases.
The Journal of biological chemistry 2004;279(15):14713-25.
2003: Jin-Peng Sun; Li Wu; Alexander A Fedorov; Steven C Almo; Zhong-Yin Zhang
Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor.
The Journal of biological chemistry 2003;278(35):33392-9.
2002: Hu Cheng; Ivana Nikolic-Hughes; Jianghua H Wang; Hua Deng; Patrick O'Brien; Li Wu; Zhong-Yin Zhang; Daniel Herschlag; Robert Callender
Environmental effects on phosphoryl group bonding probed by vibrational spectroscopy: implications for understanding phosphoryl transfer and enzymatic catalysis.
Journal of the American Chemical Society 2002;124(38):11295-306.
2001: Kui Shen; YF Keng; Li Wu; X L Guo; David S Lawrence; Zhong-Yin Zhang
Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure.
The Journal of biological chemistry 2001;276(50):47311-9.
2001: Bo Zhou; Li Wu; Kui Shen; J Zhang; David S Lawrence; Zhong-Yin Zhang
Multiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2.
The Journal of biological chemistry 2001;276(9):6506-15.
2000: Yan-Ling Zhang; Z J Yao; M Sarmiento; Li Wu; T R Burke; Zhong-Yin Zhang
Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants.
The Journal of biological chemistry 2000;275(44):34205-12.
2000: M Sarmiento; Yoram A Puius; S W Vetter; YF Keng; Li Wu; Y Zhao; David S Lawrence; Steven C Almo; Zhong-Yin Zhang
Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry 2000;39(28):8171-9.
1999: Yan-Ling Zhang; F Hollfelder; S J Gordon; L Chen; YF Keng; Li Wu; D Herschlag; Zhong-Yin Zhang
Impaired transition state complementarity in the hydrolysis of O-arylphosphorothioates by protein-tyrosine phosphatases.
Biochemistry 1999;38(37):12111-23.
1999: M Taing; YF Keng; Kui Shen; Li Wu; David S Lawrence; Zhong-Yin Zhang
Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B.
Biochemistry 1999;38(12):3793-803.
1999: YF Keng; Li Wu; Zhong-Yin Zhang
Probing the function of the conserved tryptophan in the flexible loop of the Yersinia protein-tyrosine phosphatase.
European journal of biochemistry / FEBS 1999;259(3):809-14.
1999: A Buist; Y L Zhang; Y F Keng; Li Wu; Zhong-Yin Zhang; Jeroen den Hertog
Restoration of potent protein-tyrosine phosphatase activity into the membrane-distal domain of receptor protein-tyrosine phosphatase alpha.
Biochemistry 1999;38(3):914-22.
1998: Fang Wang; W Li; Mark R Emmett; Christopher L Hendrickson; A G Marshall; Yan-Ling Zhang; Li Wu; Zhong-Yin Zhang
Conformational and dynamic changes of Yersinia protein tyrosine phosphatase induced by ligand binding and active site mutation and revealed by H/D exchange and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.
Biochemistry 1998;37(44):15289-99.
1998: Yan-Ling Zhang; YF Keng; Yu Zhao; Li Wu; Zhong-Yin Zhang
Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases.
The Journal of biological chemistry 1998;273(20):12281-7.
1998: Yu Zhao; Li Wu; S J Noh; K L Guan; Zhong-Yin Zhang
Altering the nucleophile specificity of a protein-tyrosine phosphatase-catalyzed reaction. Probing the function of the invariant glutamine residues.
The Journal of biological chemistry 1998;273(10):5484-92.
1997: Li Wu; A Buist; Jeroen den Hertog; Zhong-Yin Zhang
Comparative kinetic analysis and substrate specificity of the tandem catalytic domains of the receptor-like protein-tyrosine phosphatase alpha.
The Journal of biological chemistry 1997;272(11):6994-7002.
1997: Zhong-Yin Zhang; Li Wu
The single sulfur to oxygen substitution in the active site nucleophile of the Yersinia protein-tyrosine phosphatase leads to substantial structural and functional perturbations.
Biochemistry 1997;36(6):1362-9.
1996: Li Wu; Zhong-Yin Zhang
Probing the function of Asp128 in the lower molecular weight protein-tyrosine phosphatase-catalyzed reaction. A pre-steady-state and steady-state kinetic investigation.
Biochemistry 1996;35(17):5426-34.
1996: Zhong-Yin Zhang; A B Walsh; Li Wu; Dennis J McNamara; Ellen M Dobrusin; W Todd Miller
Determinants of substrate recognition in the protein-tyrosine phosphatase, PTP1.
The Journal of biological chemistry 1996;271(10):5386-92.
1995: Zhong-Yin Zhang; Bruce A Palfey; Li Wu; Yu Zhao
Catalytic function of the conserved hydroxyl group in the protein tyrosine phosphatase signature motif.
Biochemistry 1995;34(50):16389-96.
1995: Zhong-Yin Zhang; Li Wu; L Chen
Transition state and rate-limiting step of the reaction catalyzed by the human dual-specificity phosphatase, VHR.
Biochemistry 1995;34(49):16088-96.
1995: Zhong-Yin Zhang; G Zhou; John M Denu; Li Wu; X Tang; O Mondesert; P Russell; Elizabeth R Butch; K L Guan
Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe.
Biochemistry 1995;34(33):10560-8.