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Tsuei-Ju Wu

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Hong C Shen; Fa-Xiang Ding; Subharekha Raghavan; Qiaolin Deng; Silvi Luell; Michael J Forrest; Ester Carballo-Jane; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Qing Chen; Junying Wang; Michael S Wolff; Xinchun Tong; Tom G Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
Hong Shen; Fa-Xiang Ding; Qiaolin Deng; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Ester Carballo-Jane; Ning Ren; Tian-Quan Cai; Tsuei-Ju Wu; Kenneth K Wu; Kang Cheng; Qing Chen; Michael S Wolff; Xinchun Tong; Tom Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
Hong Shen; Michael J Szymonifka; Divya Kharbanda; Qiaolin Deng; Ester Carballo-Jane; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Andrew K P Taggart; Junying Wang; Xinchun Tong; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.

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All Publications

2010: Hong C Shen; Fa-Xiang Ding; Subharekha Raghavan; Qiaolin Deng; Silvi Luell; Michael J Forrest; Ester Carballo-Jane; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Qing Chen; Junying Wang; Michael S Wolff; Xinchun Tong; Tom G Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
Journal of medicinal chemistry 2010;53(6):2666-70.
2009: Hong Shen; Fa-Xiang Ding; Qiaolin Deng; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Ester Carballo-Jane; Ning Ren; Tian-Quan Cai; Tsuei-Ju Wu; Kenneth K Wu; Kang Cheng; Qing Chen; Michael S Wolff; Xinchun Tong; Tom Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
Journal of medicinal chemistry 2009;52(8):2587-602.
2007: Hong Shen; Michael J Szymonifka; Divya Kharbanda; Qiaolin Deng; Ester Carballo-Jane; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Andrew K P Taggart; Junying Wang; Xinchun Tong; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.
Bioorganic & medicinal chemistry letters 2007;17(24):6723-8.
2007: Hong Shen; Fa-Xiang Ding; Silvi Luell; Michael J Forrest; Ester Carballo-Jane; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K Taggart; Ning Ren; Tian-Quan Cai; Qiaolin Deng; Qing Chen; Junying Wang; Michael S Wolff; Xinchun Tong; Tom Holt; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
Journal of medicinal chemistry 2007;50(25):6303-6.
2006: Kang Cheng; Tsuei-Ju Wu; Kenneth K Wu; Claudio Sturino; Kathleen M Metters; Keith M Gottesdiener; Samuel D Wright; Zhaoyin Wang; Gary O'Neill; Eseng Lai; M Gerard Waters
Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6682-7.
2005: Kenneth K Wu; Tsuei-Ju Wu; Jayne Chin; Lyndon J Mitnaul; Melba Hernandez; Tian-Quan Cai; Ning Ren; M Gerard Waters; Samuel D Wright; Kang Cheng
Increased hypercholesterolemia and atherosclerosis in mice lacking both ApoE and leptin receptor.
Atherosclerosis 2005;181(2):251-9.
2005: Andrew K P Taggart; Jukka Kero; Xiaodong Gan; Tian-Quan Cai; Kang Cheng; Marc Ippolito; Ning Ren; Rebecca Kaplan; Kenneth Wu; Tsuei-Ju Wu; Lan Jin; Chen Liaw; Ruoping Chen; Jeremy G Richman; Daniel Connolly; Stefan Offermanns; Samuel D Wright; M Gerard Waters
(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.
The Journal of biological chemistry 2005;280(29):26649-52.
2002: Jonathan R Young; Song X Huang; Thomas F Walsh; Matthew J Wyvratt; Yi Tien Yang; Joel B Yudkovitz; Jisong Cui; George R Mount; Rena Ning Ren; Tsuei-Ju Wu; Xiaolan Shen; Kathryn A Lyons; Ann Mao; Josephine R Carlin; Bindhu V Karanam; Stella H Vincent; Kang Cheng; Mark T Goulet
2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: optimization of the tryptamine side chain.
Bioorganic & medicinal chemistry letters 2002;12(5):827-32.
2001: Wallace T Ashton; Rosemary M Sisco; Gerard Kieczykowski; Yi Tien Yang; Joel B Yudkovitz; Jisong Cui; George R Mount; Rena Ning Ren; Tsuei-Ju Wu; X Shen; Kathryn A Lyons; Ann Mao; Josephine R Carlin; Bindhu V Karanam; Stella H Vincent; Kang Cheng; Mark T Goulet
Orally bioavailable, indole-based nonpeptide GnRH receptor antagonists with high potency and functional activity.
Bioorganic & medicinal chemistry letters 2001;11(19):2597-602.
1998: Lihu Yang; Scott Berk; Susan P Rohrer; Ralph T Mosley; Liangqin Guo; Dennis J Underwood; Byron H Arison; Elizabeth T Birzin; Edward C Hayes; Sudha Warrier Mitra; Rupa M Parmar; Kang Cheng; Tsuei-Ju Wu; B S Butler; F Foor; Alexander Pasternak; Y Pan; M Silva; Roger M Freidinger; Roy G Smith; Kevin Chapman; James M Schaeffer; Arthur A Patchett
Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10836-41.