Akinori Akaike

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Niidome Tetsuhiro; Goto Yasuaki; Kato Masaru; Wang Pi-Lin; Goh Saori; Tanaka Naoki; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Non-fibrillar amyloid-beta peptide reduces NMDA-induced neurotoxicity, but not AMPA-induced neurotoxicity.
Hama Yasuhiro; Katsuki Hiroshi; Izumi Yasuhiko; Kume Toshiaki; Akaike Akinori
Excitotoxicity-associated p53 expression in adult rat retina is mediated by calpain activity but not by Cl- influx.
Izumi Yasuhiko; Yamamoto Noriyuki; Matsuo Takaaki; Wakita Seiko; Takeuchi Hiroki; Kume Toshiaki; Katsuki Hiroshi; Sawada Hideyuki; Akaike Akinori
Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation.

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2009: Niidome Tetsuhiro; Goto Yasuaki; Kato Masaru; Wang Pi-Lin; Goh Saori; Tanaka Naoki; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Non-fibrillar amyloid-beta peptide reduces NMDA-induced neurotoxicity, but not AMPA-induced neurotoxicity.
Biochemical and biophysical research communications 2009;386(4):734-8.
2009: Hama Yasuhiro; Katsuki Hiroshi; Izumi Yasuhiko; Kume Toshiaki; Akaike Akinori
Excitotoxicity-associated p53 expression in adult rat retina is mediated by calpain activity but not by Cl- influx.
Journal of pharmacological sciences 2009;110(4):493-6.
2009: Izumi Yasuhiko; Yamamoto Noriyuki; Matsuo Takaaki; Wakita Seiko; Takeuchi Hiroki; Kume Toshiaki; Katsuki Hiroshi; Sawada Hideyuki; Akaike Akinori
Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation.
Journal of neurochemistry 2009;110(2):745-55.
2009: Wang Pi-Lin; Niidome Tetsuhiro; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene.
Journal of neuroscience research 2009;87(9):2105-14.
2009: Takahashi Keita; Niidome Tetsuhiro; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway.
Journal of neurochemistry 2009;109(5):1324-37.
2009: Kubota Yoshie; Yano Yoshitaka; Morimoto Takeshi; Seki Susumu; Takada Kaori; Kuramoto Nobuo; Maeda Yuko; Akaike Akinori; Hiraide Atsushi
Reliability of evaluation for communication competency in pharmaceutical objective structured clinical examination (OSCE).
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2009;129(5):609-16.
2009: Takada-Takatori Yuki; Kume Toshiaki; Izumi Yasuhiko; Ohgi Yuta; Niidome Tetsuhiro; Fujii Takeshi; Sugimoto Hachiro; Akaike Akinori
Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation.
Biological & pharmaceutical bulletin 2009;32(3):318-24.
2009: Akaike Akinori
Functional changes induced by long-term stimulation of nicotinic acetylcholine receptors. Foreword.
Biological & pharmaceutical bulletin 2009;32(3):317.
2009: Nonaka Hideki; Niidome Tetsuhiro; Shinozuka Yoriko; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
A role for SOX2 in the generation of microtubule-associated protein 2-positive cells from microglia.
Biochemical and biophysical research communications 2009;380(1):60-4.
2009: Takeuchi Hiroki; Yanagida Takashi; Inden Masatoshi; Takata Kazuyuki; Kitamura Yoshihisa; Yamakawa Kentaro; Sawada Hideyuki; Izumi Yasuhiko; Yamamoto Noriyuki; Kihara Takeshi; Uemura Kengo; Inoue Haruhisa; Taniguchi Takashi; Akaike Akinori; Takahashi Ryosuke; Shimohama Shun
Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models.
Journal of neuroscience research 2009;87(2):576-85.
2009: Nishimoto Takaaki; Kihara Takeshi; Akaike Akinori; Niidome Tetsuhiro; Sugimoto Hachiro
AMPA reduces surface expression of NR1 through regulation of GSK3beta.
Neuroreport 2009;20(2):161-5.
2009: Kume Toshiaki; Ito Ryo; Taguchi Ryota; Izumi Yasuhiko; Katsuki Hiroshi; Niidome Tetsuhiro; Takada-Takatori Yuki; Sugimoto Hachiro; Akaike Akinori
Serofendic acid promotes stellation induced by cAMP and cGMP analogs in cultured cortical astrocytes.
Journal of pharmacological sciences 2009;109(1):110-8.
2009: Ohnishi Masatoshi; Katsuki Hiroshi; Takagi Mikako; Kume Toshiaki; Akaike Akinori
Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures.
European journal of pharmacology 2009;602(2-3):288-93.
2008: Takahashi Keita; Niidome Tetsuhiro; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Phosphorylation of amyloid precursor protein (APP) at Tyr687 regulates APP processing by alpha- and gamma-secretase.
Biochemical and biophysical research communications 2008;377(2):544-9.
2008: Takada-Takatori Yuki; Kume Toshiaki; Ohgi Yuta; Izumi Yasuhiko; Niidome Tetsuhiro; Fujii Takeshi; Sugimoto Hachiro; Akaike Akinori
Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil.
Journal of neuroscience research 2008;86(16):3575-83.
2008: Oda Toru; Kume Toshiaki; Izumi Yasuhiko; Takada-Takatori Yuki; Niidome Tetsuhiro; Akaike Akinori
Bromocriptine, a dopamine D(2) receptor agonist with the structure of the amino acid ergot alkaloids, induces neurite outgrowth in PC12 cells.
European journal of pharmacology 2008;598(1-3):27-31.
2008: Kume Toshiaki; Kawato Yuka; Osakada Fumitaka; Izumi Yasuhiko; Katsuki Hiroshi; Nakagawa Takayuki; Kaneko Shuji; Niidome Tetsuhiro; Takada-Takatori Yuki; Akaike Akinori
Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype.
Neuroscience letters 2008;443(3):199-203.
2008: Hama Yasuhiro; Katsuki Hiroshi; Suminaka Chihiro; Kume Toshiaki; Akaike Akinori
Chloride-dependent acute excitotoxicity in adult rat retinal ganglion cells.
Neuropharmacology 2008;55(5):677-86.
2008: Niidome Tetsuhiro; Taniuchi Nobuhiko; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice.
Neuroreport 2008;19(14):1361-4.
2008: Shimmyo Yoshiari; Kihara Takeshi; Akaike Akinori; Niidome Tetsuhiro; Sugimoto Hachiro
Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation.
Neuroreport 2008;19(13):1329-33.
2008: Takada-Takatori Yuki; Kume Toshiaki; Ohgi Yuta; Fujii Takeshi; Niidome Tetsuhiro; Sugimoto Hachiro; Akaike Akinori
Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment.
European journal of pharmacology 2008;590(1-3):150-6.
2008: Akasofu Shigeru; Sawada Kohei; Kosasa Takashi; Hihara Hiroe; Ogura Hiroo; Akaike Akinori
Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine.
European journal of pharmacology 2008;588(2-3):189-97.
2008: Shimmyo Yoshiari; Kihara Takeshi; Akaike Akinori; Niidome Tetsuhiro; Sugimoto Hachiro
Three distinct neuroprotective functions of myricetin against glutamate-induced neuronal cell death: involvement of direct inhibition of caspase-3.
Journal of neuroscience research 2008;86(8):1836-45.
2008: Nakamura Tomohiro; Kume Toshiaki; Katsuki Hiroshi; Niidome Tetsuhiro; Sugimoto Hachiro; Akaike Akinori
Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats.
European journal of pharmacology 2008;586(1-3):151-5.
2008: Niidome Tetsuhiro; Matsuda Satoru; Nonaka Hideki; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
A molecular pathway involved in the generation of microtubule-associated protein 2-positive cells from microglia.
Biochemical and biophysical research communications 2008;370(1):184-8.
2008: Shimmyo Yoshiari; Kihara Takeshi; Akaike Akinori; Niidome Tetsuhiro; Sugimoto Hachiro
Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features.
Biochimica et biophysica acta 2008;1780(5):819-25.
2008: Matsuda Satoru; Niidome Tetsuhiro; Nonaka Hideki; Goto Yasuaki; Fujimura Kazuhiko; Kato Masaru; Nakanishi Masaya; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Microtubule-associated protein 2-positive cells derived from microglia possess properties of functional neurons.
Biochemical and biophysical research communications 2008;368(4):971-6.
2008: Nishimoto Takaaki; Kihara Takeshi; Akaike Akinori; Niidome Tetsuhiro; Sugimoto Hachiro
alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta.
Journal of neuroscience research 2008;86(5):1096-105.
2008: Goto Yasuaki; Niidome Tetsuhiro; Hongo Haruyuki; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease.
European journal of pharmacology 2008;583(1):84-91.
2008: Izumi Yasuhiko; Yamamoto Noriyuki; Kume Toshiaki; Katsuki Hiroshi; Sawada Hideyuki; Akaike Akinori
Regulation of intracellular dopamine levels by dopaminergic drugs: involvement of vesicular monoamine transporter.
European journal of pharmacology 2008;582(1-3):52-61.
2008: Fujimoto Shinji; Katsuki Hiroshi; Ohnishi Masatoshi; Takagi Mikako; Kume Toshiaki; Akaike Akinori
Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(3):506-15.
2008: Yanagisawa Daijiro; Kitamura Yoshihisa; Inden Masatoshi; Takata Kazuyuki; Taniguchi Takashi; Morikawa Shigehiro; Morita Masahito; Inubushi Toshiro; Tooyama Ikuo; Taira Takahiro; Iguchi-Ariga Sanae M M; Akaike Akinori; Ariga Hiroyoshi
DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(3):563-78.
2008: Shimmyo Yoshiari; Kihara Takeshi; Akaike Akinori; Niidome Tetsuhiro; Sugimoto Hachiro
Multifunction of myricetin on A beta: neuroprotection via a conformational change of A beta and reduction of A beta via the interference of secretases.
Journal of neuroscience research 2008;86(2):368-77.
2007: Taniuchi Nobuhiko; Niidome Tetsuhiro; Goto Yasuaki; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic mice.
Neuroreport 2007;18(17):1801-5.
2007: Terauchi Taro; Asai Naoki; Doko Takashi; Taguchi Ryota; Takenaka Osamu; Sakurai Hideki; Yonaga Masahiro; Kimura Teiji; Kajiwara Akiharu; Niidome Tetsuhiro; Kume Toshiaki; Akaike Akinori; Sugimoto Hachiro
Synthesis and pharmacological profile of serofendic acids A and B.
Bioorganic & medicinal chemistry 2007;15(22):7098-107.
2007: Katsuki Hiroshi; Watanabe Yoshinori; Fujimoto Shinji; Kume Toshiaki; Akaike Akinori
Contribution of endogenous glycine and d-serine to excitotoxic and ischemic cell death in rat cerebrocortical slice cultures.
Life sciences 2007;81(9):740-9.
2007: Oda Toru; Kume Toshiaki; Katsuki Hiroshi; Niidome Tetsuhiro; Sugimoto Hachiro; Akaike Akinori
Donepezil potentiates nerve growth factor-induced neurite outgrowth in PC12 cells.
Journal of pharmacological sciences 2007;104(4):349-54.
2007: Ohnishi Masatoshi; Katsuki Hiroshi; Fujimoto Shinji; Takagi Mikako; Kume Toshiaki; Akaike Akinori
Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury.
Experimental neurology 2007;206(1):43-52.
2007: Niidome Tetsuhiro; Takahashi Keita; Goto Yasuaki; Goh Saori; Tanaka Naoki; Kamei Kaeko; Ichida Masatoshi; Hara Saburo; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity.
Neuroreport 2007;18(8):813-6.
2007: Osakada Fumitaka; Ooto Sotaro; Akagi Tadamichi; Mandai Michiko; Akaike Akinori; Takahashi Masayo
Wnt signaling promotes regeneration in the retina of adult mammals.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(15):4210-9.
2007: Nakanishi Masaya; Niidome Tetsuhiro; Matsuda Satoru; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells.
The European journal of neuroscience 2007;25(3):649-58.
2007: Izumi Yasuhiko; Sawada Hideyuki; Yamamoto Noriyuki; Kume Toshiaki; Katsuki Hiroshi; Shimohama Shun; Akaike Akinori
Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity.
European journal of pharmacology 2007;557(2-3):132-40.
2007: Yamamoto Noriyuki; Sawada Hideyuki; Izumi Yasuhiko; Kume Toshiaki; Katsuki Hiroshi; Shimohama Shun; Akaike Akinori
Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease.
The Journal of biological chemistry 2007;282(7):4364-72.
2007: Okawara Mitsugi; Katsuki Hiroshi; Kurimoto Emi; Shibata Haruki; Kume Toshiaki; Akaike Akinori
Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults.
Biochemical pharmacology 2007;73(4):550-60.
2007: Fujimoto S; Katsuki H; Ohnishi M; Takagi M; Kume T; Akaike A
Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo.
Neuroscience 2007;144(2):694-701.
2007: Akao Masaharu; Takeda Toshihiro; Kita Toru; Kume Toshiaki; Akaike Akinori
Serofendic acid, a substance extracted from fetal calf serum, as a novel drug for cardioprotection.
Cardiovascular drug reviews 2007;25(4):333-41.
2006: Goto Yasuaki; Niidome Tetsuhiro; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Amyloid beta-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor.
Biochemical and biophysical research communications 2006;351(1):259-65.
2006: Takada-Takatori Yuki; Kume Toshiaki; Sugimoto Mitsuhiro; Katsuki Hiroshi; Niidome Tetsuhiro; Sugimoto Hachiro; Fujii Takeshi; Okabe Susumu; Akaike Akinori
Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity.
European journal of pharmacology 2006;549(1-3):19-26.
2006: Hama Yasuhiro; Katsuki Hiroshi; Tochikawa Yoshinaga; Suminaka Chihiro; Kume Toshiaki; Akaike Akinori
Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo.
Neuroscience research 2006;56(3):279-85.
2006: Niidome Tetsuhiro; Morimoto Noriko; Iijima Sohgo; Akaike Akinori; Kihara Takeshi; Sugimoto Hachiro
Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation.
European journal of pharmacology 2006;548(1-3):1-8.
2006: Yanagisawa Daijiro; Qi Meirigeng; Kim Do-hoon; Kitamura Yoshihisa; Inden Masatoshi; Tsuchiya Daiju; Takata Kazuyuki; Taniguchi Takashi; Yoshimoto Kanji; Shimohama Shun; Akaike Akinori; Sumi Shoichiro; Inoue Kazutomo
Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells.
Neuroscience letters 2006;407(1):74-9.
2006: Terauchi Taro; Doko Takashi; Yonaga Masahiro; Kajiwara Akiharu; Niidome Tetsuhiro; Taguchi Ryota; Kume Toshiaki; Akaike Akinori; Sugimoto Hachiro
Synthesis and neuroprotective effects of serofendic acid analogues.
Bioorganic & medicinal chemistry letters 2006;16(19):5080-3.
2006: Takada-Takatori Yuki; Kume Toshiaki; Sugimoto Mitsuhiro; Katsuki Hiroshi; Sugimoto Hachiro; Akaike Akinori
Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade.
Neuropharmacology 2006;51(3):474-86.
2006: Kume Toshiaki; Taguchi Ryota; Katsuki Hiroshi; Akao Masaharu; Sugimoto Hachiro; Kaneko Shuji; Akaike Akinori
Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation.
European journal of pharmacology 2006;542(1-3):69-76.
2006: Katsuki Hiroshi; Okawara Mitsugi; Shibata Haruki; Kume Toshiaki; Akaike Akinori
Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture.
Journal of neurochemistry 2006;97(5):1232-42.
2006: Takeda Toshihiro; Akao Masaharu; Matsumoto-Ida Madoka; Kato Masashi; Takenaka Hiroyuki; Kihara Yasuki; Kume Toshiaki; Akaike Akinori; Kita Toru
Serofendic acid, a novel substance extracted from fetal calf serum, protects against oxidative stress in neonatal rat cardiac myocytes.
Journal of the American College of Cardiology 2006;47(9):1882-90.
2006: Kaneko Shuji; Kawakami Seiko; Hara Yuji; Wakamori Minoru; Itoh Etsuko; Minami Toshiyuki; Takada Yuki; Kume Toshiaki; Katsuki Hiroshi; Mori Yasuo; Akaike Akinori
A critical role of TRPM2 in neuronal cell death by hydrogen peroxide.
Journal of pharmacological sciences 2006;101(1):66-76.
2006: Akaike Akinori
Preclinical evidence of neuroprotection by cholinesterase inhibitors.
Alzheimer disease and associated disorders 2006;20(2 Suppl 1):S8-11.
2006: Shirakawa Hisashi; Katsuki Hiroshi; Kume Toshiaki; Kaneko Shuji; Akaike Akinori
Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons.
British journal of pharmacology 2006;147(7):729-36.
2006: Fujimoto Shinji; Katsuki Hiroshi; Kume Toshiaki; Akaike Akinori
Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures.
Neurobiology of disease 2006;22(1):130-42.
2006: Taguchi Ryota; Shirakawa Hisashi; Yamaguchi Toshiaki; Kume Toshiaki; Katsuki Hiroshi; Akaike Akinori
Nitric oxide-mediated effect of nipradilol, an alpha- and beta-adrenergic blocker, on glutamate neurotoxicity in rat cortical cultures.
European journal of pharmacology 2006;535(1-3):86-94.
2006: Takahata K; Shimazu S; Katsuki H; Yoneda F; Akaike A
Effects of selegiline on antioxidant systems in the nigrostriatum in rat.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(2):151-8.
2006: Shibata Haruki; Katsuki Hiroshi; Okawara Mitsugi; Kume Toshiaki; Akaike Akinori
c-Jun N-terminal kinase inhibition and alpha-tocopherol protect midbrain dopaminergic neurons from interferon-gamma/lipopolysaccharide-induced injury without affecting nitric oxide production.
Journal of neuroscience research 2006;83(1):102-9.
2005: Kume Toshiaki; Sugimoto Mitsuhiro; Takada Yuki; Yamaguchi Toshiaki; Yonezawa Atsushi; Katsuki Hiroshi; Sugimoto Hachiro; Akaike Akinori
Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons.
European journal of pharmacology 2005;527(1-3):77-85.
2005: Inden Masatoshi; Kitamura Yoshihisa; Kondo Jun-Ichi; Hayashi Kousuke; Yanagida Takashi; Takata Kazuyuki; Tsuchiya Daiju; Yanagisawa Daijiro; Nishimura Kaneyasu; Taniguchi Takashi; Shimohama Shun; Sugimoto Hachiro; Akaike Akinori
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.
Journal of neurochemistry 2005;95(4):950-61.
2005: Akaike Akinori; Katsuki Hiroshi; Kume Toshiaki
[Endogenous factors regulating neuronal apoptosis]
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2005;25(5):245-50.
2005: Izumi Yasuhiko; Sawada Hideyuki; Yamamoto Noriyuki; Kume Toshiaki; Katsuki Hiroshi; Shimohama Shun; Akaike Akinori
Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells.
Journal of neuroscience research 2005;82(1):126-37.
2005: Hirami Chieko; Takahata Kazue; Shimazu Seiichiro; Yoneda Fumio; Hayashi Kyozo; Katsuki Hiroshi; Akaike Akinori
Effects of R-(-)-BPAP on the expressions of neurotrophins and their receptors in mesencephalic slices.
Biological & pharmaceutical bulletin 2005;28(8):1524-6.
2005: Katsuki Hiroshi; Akaike Akinori
Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.
Neuroreport 2005;16(11):1157-61.
2005: Kume Toshiaki; Kawai Yuko; Yoshida Kohei; Nakamizo Tomoki; Kanki Rie; Sawada Hideyuki; Katsuki Hiroshi; Shimohama Shun; Sugimoto Hachiro; Akaike Akinori
Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons.
Neuroscience letters 2005;383(3):199-202.
2005: Shirakawa Hisashi; Katsuki Hiroshi; Kume Toshiaki; Kaneko Shuji; Akaike Akinori
Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons.
The European journal of neuroscience 2005;21(9):2329-35.
2005: Kita Tomoko; Nakagawa Takayuki; Kim Tae-Soo; Iwai Koji; Takebayashi Shinji; Akaike Akinori; Ito Juichi
Serofendic acid promotes survival of auditory hair cells and neurons of mice.
Neuroreport 2005;16(7):689-92.
2005: Nakamizo Tomoki; Kawamata Jun; Yamashita Hirofumi; Kanki Rie; Kihara Takeshi; Sawada Hideyuki; Akaike Akinori; Shimohama Shun
Stimulation of nicotinic acetylcholine receptors protects motor neurons.
Biochemical and biophysical research communications 2005;330(4):1285-9.
2005: Izumi Yasuhiko; Sawada Hideyuki; Sakka Noriko; Yamamoto Noriyuki; Kume Toshiaki; Katsuki Hiroshi; Shimohama Shun; Akaike Akinori
p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.
Journal of neuroscience research 2005;79(6):849-60.
2005: Katsuki Hiroshi; Shinohara Atsumi; Fujimoto Shinji; Kume Toshiaki; Akaike Akinori
Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures.
European journal of pharmacology 2005;508(1-3):85-91.
2004: Osakada Fumitaka; Hashino Asami; Kume Toshiaki; Katsuki Hiroshi; Kaneko Shuji; Akaike Akinori
Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons.
Neuropharmacology 2004;47(6):904-15.
2004: Katsuki Hiroshi; Nonaka Miki; Shirakawa Hisashi; Kume Toshiaki; Akaike Akinori
Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices.
The Journal of pharmacology and experimental therapeutics 2004;311(2):836-44.
2004: Fujimoto Shinji; Katsuki Hiroshi; Kume Toshiaki; Kaneko Shuji; Akaike Akinori
Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures.
Neuroscience research 2004;50(2):179-87.
2004: Osakada Fumitaka; Kawato Yuka; Kume Toshiaki; Katsuki Hiroshi; Sugimoto Hachiro; Akaike Akinori
Serofendic acid, a sulfur-containing diterpenoid derived from fetal calf serum, attenuates reactive oxygen species-induced oxidative stress in cultured striatal neurons.
The Journal of pharmacology and experimental therapeutics 2004;311(1):51-9.
2004: Inden Masatoshi; Kim Dohoon; Gu Yuanjin; Kitamura Yoshihisa; Kondo Jun-ichi; Tsuchiya Daiju; Taniguchi Takashi; Shimohama Shun; Akaike Akinori; Sumi Shoichiro; Inoue Kazutomo
Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons.
Journal of pharmacological sciences 2004;96(1):53-64.
2004: Kume Toshiaki; Katsuki Hiroshi; Akaike Akinori
Endogenous factors regulating neuronal death induced by radical stress.
Biological & pharmaceutical bulletin 2004;27(7):964-7.
2004: Kanki Rie; Nakamizo Tomoki; Yamashita Hirofumi; Kihara Takeshi; Sawada Hideyuki; Uemura Kengo; Kawamata Jun; Shibasaki Hiroshi; Akaike Akinori; Shimohama Shun
Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons.
Brain research 2004;1015(1-2):73-81.
2004: Sawada Hideyuki; Kohno Ryuichi; Kihara Takeshi; Izumi Yasuhiko; Sakka Noriko; Ibi Masakazu; Nakanishi Miki; Nakamizo Tomoki; Yamakawa Kentarou; Shibasaki Hiroshi; Yamamoto Noriyuki; Akaike Akinori; Inden Masatoshi; Kitamura Yoshihisa; Taniguchi Takashi; Shimohama Shun
Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions.
The Journal of biological chemistry 2004;279(11):10710-9.
2004: Katsuki Hiroshi; Akaike Akinori
Excitotoxic degeneration of hypothalamic orexin neurons in slice culture.
Neurobiology of disease 2004;15(1):61-9.
2004: Katsuki Hiroshi; Yamamoto Rie; Nakata Daisuke; Kume Toshiaki; Akaike Akinori
Neuronal nitric oxide synthase is crucial for ganglion cell death in rat retinal explant cultures.
Journal of pharmacological sciences 2004;94(1):77-80.
2003: Sakka Noriko; Sawada Hideyuki; Izumi Yasuhiko; Kume Toshiaki; Katsuki Hiroshi; Kaneko Shuji; Shimohama Shun; Akaike Akinori
Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone.
Neuroreport 2003;14(18):2425-8.
2003: Shimazu Seiichiro; Tsunekawa Hiroko; Yoneda Fumio; Katsuki Hiroshi; Akaike Akinori; Janowsky Aaron
Transporter-mediated actions of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane.
European journal of pharmacology 2003;482(1-3):9-16.
2003: Akaike Akinori; Katsuki Hiroshi; Kume Toshiaki
Pharmacological and physiological properties of serofendic acid, a novel neuroprotective substance isolated from fetal calf serum.
Life sciences 2003;74(2-3):263-9.
2003: Taguchi Ryota; Nishikawa Hiroyuki; Kume Toshiaki; Terauchi Taro; Kaneko Shuji; Katsuki Hiroshi; Yonaga Masahiro; Sugimoto Hachiro; Akaike Akinori
Serofendic acid prevents acute glutamate neurotoxicity in cultured cortical neurons.
European journal of pharmacology 2003;477(3):195-203.
2003: Shibata Haruki; Katsuki Hiroshi; Nishiwaki Mayumi; Kume Toshiaki; Kaneko Shuji; Akaike Akinori
Lipopolysaccharide-induced dopaminergic cell death in rat midbrain slice cultures: role of inducible nitric oxide synthase and protection by indomethacin.
Journal of neurochemistry 2003;86(5):1201-12.
2003: Takahata Kazue; Katsuki Hiroshi; Kume Toshiaki; Ito Ken; Tochikawa Yoshinaga; Muraoka Shizuko; Yoneda Fumio; Kashii Satoshi; Honda Yoshihito; Akaike Akinori
Retinal neurotoxicity of nitric oxide donors with different half-life of nitric oxide release: involvement of N-methyl-D-aspartate receptor.
Journal of pharmacological sciences 2003;92(4):428-32.
2003: Yamauchi Tomofusa; Kashii Satoshi; Yasuyoshi Hiroki; Zhang Shen; Honda Yoshihito; Ujihara Hisamitsu; Akaike Akinori
Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neurons.
Neuroscience letters 2003;347(3):155-8.
2003: Takada Yuki; Yonezawa Atsushi; Kume Toshiaki; Katsuki Hiroshi; Kaneko Shuji; Sugimoto Hachiro; Akaike Akinori
Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons.
The Journal of pharmacology and experimental therapeutics 2003;306(2):772-7.
2003: Kitamura Yoshihisa; Taniguchi Takashi; Shimohama Shun; Akaike Akinori; Nomura Yasuyuki
Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists.
Neurochemical research 2003;28(7):1035-40.
2003: Yamauchi Tomofusa; Kashii Satoshi; Yasuyoshi Hiroki; Zhang Shen; Honda Yoshihito; Akaike Akinori
Mitochondrial ATP-sensitive potassium channel: a novel site for neuroprotection.
Investigative ophthalmology & visual science 2003;44(6):2750-6.
2003: Katsuki Hiroshi; Shibata Haruki; Takenaka Chikako; Kume Toshiaki; Kaneko Shuji; Akaike Akinori
N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures.
Neuroscience letters 2003;341(2):123-6.
2003: Takahata Kazue; Katsuki Hiroshi; Kume Toshiaki; Nakata Daisuke; Ito Ken; Muraoka Shizuko; Yoneda Fumio; Kashii Satoshi; Honda Yoshihito; Akaike Akinori
Retinal neuronal death induced by intraocular administration of a nitric oxide donor and its rescue by neurotrophic factors in rats.
Investigative ophthalmology & visual science 2003;44(4):1760-6.
2003: Osakada Fumitaka; Hashino Asami; Kume Toshiaki; Katsuki Hiroshi; Kaneko Shuji; Akaike Akinori
Neuroprotective effects of alpha-tocopherol on oxidative stress in rat striatal cultures.
European journal of pharmacology 2003;465(1-2):15-22.
2003: Kitamura Yoshihisa; Ishida Yuji; Takata Kazuyuki; Mizutani Hiroto; Kakimura Jun-ichi; Inden Masatoshi; Nakata Junko; Taniguchi Takashi; Tsukahara Tetsuya; Akaike Akinori; Shimohama Shun
Hyperbilirubinemia protects against focal ischemia in rats.
Journal of neuroscience research 2003;71(4):544-50.
2003: Nakamizo Tomoki; Kawamata Jun; Yoshida Kohei; Kawai Yuko; Kanki Rie; Sawada Hideyuki; Kihara Takeshi; Yamashita Hirofumi; Shibasaki Hiroshi; Akaike Akinori; Shimohama Shun
Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons.
Journal of neuroscience research 2003;71(4):485-95.
2003: Takahata Kazue; Katsuki Hiroshi; Kobayashi Yutaka; Muraoka Shizuko; Yoneda Fumio; Kume Toshiaki; Kashii Satoshi; Honda Yoshihito; Akaike Akinori
Protective effects of selegiline and desmethylselegiline against N-methyl-D-aspartate-induced rat retinal damage.
European journal of pharmacology 2003;458(1-2):81-9.
2002: Manabe Shin-ichi; Kashii Satoshi; Honda Yoshihito; Yamamoto Rie; Katsuki Hiroshi; Akaike Akinori
Quantification of axotomized ganglion cell death by explant culture of the rat retina.
Neuroscience letters 2002;334(1):33-6.
2002: Kume Toshiaki; Nishikawa Hiroyuki; Taguchi Ryota; Hashino Asami; Katsuki Hiroshi; Kaneko Shuji; Minami Masabumi; Satoh Masamichi; Akaike Akinori
Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro.
European journal of pharmacology 2002;455(2-3):91-100.
2002: Shirakawa Hisashi; Katsuki Hiroshi; Kume Toshiaki; Kaneko Shuji; Ito Juichi; Akaike Akinori
Regulation of N-methyl-D-aspartate cytotoxicity by neuroactive steroids in rat cortical neurons.
European journal of pharmacology 2002;454(2-3):165-75.
2002: Kihara Takeshi; Shimohama Shun; Sawada Hideyuki; Honda Kazuhiro; Nakamizo Tomoki; Kanki Rie; Yamashita Hiroshi; Akaike Akinori
Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.
Journal of neuroscience research 2002;70(3):274-82.
2002: Katayama Takahiro; Minami Masabumi; Nakamura Mika; Ito Misato; Katsuki Hiroshi; Akaike Akinori; Satoh Masamichi
Excitotoxic injury induces production of monocyte chemoattractant protein-1 in rat cortico-striatal slice cultures.
Neuroscience letters 2002;328(3):277-80.
2002: Sawada Hideyuki; Ibi Masakazu; Kihara Takeshi; Honda Kazuhiro; Nakamizo Tomoki; Kanki Rie; Nakanishi Miki; Sakka Noriko; Akaike Akinori; Shimohama Shun
Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model.
Neuropharmacology 2002;42(8):1056-64.
2002: Kume Toshiaki; Asai Naoki; Nishikawa Hiroyuki; Mano Nariyasu; Terauchi Taro; Taguchi Ryota; Shirakawa Hisashi; Osakada Fumitaka; Mori Hiroki; Asakawa Naoki; Yonaga Masahiro; Nishizawa Yukio; Sugimoto Hachiro; Shimohama Shun; Katsuki Hiroshi; Kaneko Shuji; Akaike Akinori
Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3288-93.
2002: Yoshida Kohei; Nakagawa Takayuki; Kaneko Shuji; Akaike Akinori; Satoh Masamichi
Adenosine 5'-triphosphate inhibits slow depolarization induced by repetitive dorsal root stimulation via P2Y purinoceptors in substantia gelatinosa neurons of the adult rat spinal cord slices with the dorsal root attached.
Neuroscience letters 2002;320(3):121-4.
2002: Yasuyoshi Hiroki; Kashii Satoshi; Kikuchi Masashi; Zhang Shen; Honda Yoshihito; Akaike Akinori
New insight into the functional role of acetylcholine in developing embryonic rat retinal neurons.
Investigative ophthalmology & visual science 2002;43(2):446-51.
2002: Akaike Akinori; Katsuki Hiroshi; Kume Toshiaki
[Role of nitric oxide in survival and death of neurons]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2002;119(1):15-20.
2002: Kaneko Shuji; Cooper Conan B; Nishioka Naoto; Yamasaki Hironobu; Suzuki Atsushi; Jarvis Scott E; Akaike Akinori; Satoh Masamichi; Zamponi Gerald W
Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(1):82-92.
2001: Kanki H; Kinoshita M; Akaike A; Satoh M; Mori Y; Kaneko S
Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channels.
Molecular pharmacology 2001;60(5):989-98.
2001: Kinoshita M; Nukada T; Asano T; Mori Y; Akaike A; Satoh M; Kaneko S
Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels.
The Journal of biological chemistry 2001;276(31):28731-8.
2001: Shimazu S; Takahata K; Katsuki H; Tsunekawa H; Tanigawa A; Yoneda F; Knoll J; Akaike A
(-)-1-(Benzofuran-2-yl)-2-propylaminopentane enhances locomotor activity in rats due to its ability to induce dopamine release.
European journal of pharmacology 2001;421(3):181-9.
2001: Honda K; Shimohama S; Sawada H; Kihara T; Nakamizo T; Shibasaki H; Akaike A
Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons.
Journal of neuroscience research 2001;64(5):466-75.
2001: Ibi M; Sawada H; Nakanishi M; Kume T; Katsuki H; Kaneko S; Shimohama S; Akaike A
Protective effects of 1 alpha,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture.
Neuropharmacology 2001;40(6):761-71.
2001: Kitamura Y; Ishida Y; Takata K; Kakimura J; Mizutani H; Shimohama S; Akaike A; Taniguchi T
Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia.
Brain research 2001;898(1):181-5.
2001: Kihara T; Shimohama S; Sawada H; Honda K; Nakamizo T; Shibasaki H; Kume T; Akaike A
alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity.
The Journal of biological chemistry 2001;276(17):13541-6.
2001: Katsuki H; Tomita M; Takenaka C; Shirakawa H; Shimazu S; Ibi M; Kume T; Kaneko S; Akaike A
Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity.
Journal of neurochemistry 2001;76(5):1336-45.
2001: Katsuki H; Takenaka C; Kume T; Kaneko S; Akaike A
Requirement of neural activity for the maintenance of dopaminergic neurons in rat midbrain slice cultures.
Neuroscience letters 2001;300(3):166-70.
2001: Urushitani M; Nakamizo T; Inoue R; Sawada H; Kihara T; Honda K; Akaike A; Shimohama S
N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx.
Journal of neuroscience research 2001;63(5):377-87.
2000: Kitamura Y; Shimohama S; Akaike A; Taniguchi T
The parkinsonian models: invertebrates to mammals.
Japanese journal of pharmacology 2000;84(3):237-43.
2000: Nakamizo T; Urushitani M; Inoue R; Shinohara A; Sawada H; Honda K; Kihara T; Akaike A; Shimohama S
Protection of cultured spinal motor neurons by estradiol.
Neuroreport 2000;11(16):3493-7.
2000: Zhang S; Kashii S; Yasuyoshi H; Kikuchi M; Honda Y; Kaneda K; Sato S; Akaike A
Protective effects of ifenprodil against glutamate-induced neurotoxicity in cultured retinal neurons.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2000;238(10):846-52.
2000: Ohmachi S; Watanabe Y; Mikami T; Kusu N; Ibi T; Akaike A; Itoh N
FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain.
Biochemical and biophysical research communications 2000;277(2):355-60.
2000: Kinoshita M; Akaike A; Satoh M; Kaneko S
Positive regulation of capacitative Ca2+ entry by intracellular Ca2+ in Xenopus oocytes expressing rat TRP4.
Cell calcium 2000;28(3):151-9.
2000: Nishikawa H; Hashino A; Kume T; Katsuki H; Kaneko S; Akaike A
Involvement of direct inhibition of NMDA receptors in the effects of sigma-receptor ligands on glutamate neurotoxicity in vitro.
European journal of pharmacology 2000;404(1-2):41-8.
2000: Yasuyoshi H; Kashii S; Zhang S; Nishida A; Yamauchi T; Honda Y; Asano Y; Sato S; Akaike A
Protective effect of bradykinin against glutamate neurotoxicity in cultured rat retinal neurons.
Investigative ophthalmology & visual science 2000;41(8):2273-8.
2000: Sawada H; Ibi M; Kihara T; Urushitani M; Honda K; Nakanishi M; Akaike A; Shimohama S
Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(9):1202-14.
2000: Honda K; Sawada H; Kihara T; Urushitani M; Nakamizo T; Akaike A; Shimohama S
Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons.
Journal of neuroscience research 2000;60(3):321-7.
2000: Yamaoka J; Kume T; Akaike A; Miyachi Y
Suppressive effect of zinc ion on iNOS expression induced by interferon-gamma or tumor necrosis factor-alpha in murine keratinocytes.
Journal of dermatological science 2000;23(1):27-35.
2000: Toriu N; Akaike A; Yasuyoshi H; Zhang S; Kashii S; Honda Y; Shimazawa M; Hara H
Lomerizine, a Ca2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rat retina.
Experimental eye research 2000;70(4):475-84.
2000: Zhang S; Kashii S; Yasuyoshi H; Honda Y; Ujihara H; Sasa M; Tamura Y; Akaike A
Involvement of NMDA-receptor in kainate-induced neurotoxicity in cultured fetal retinal neurons.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2000;238(3):243-8.
2000: Sawada H; Ibi M; Kihara T; Urushitani M; Nakanishi M; Akaike A; Shimohama S
Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons.
Journal of neurochemistry 2000;74(3):1175-84.
2000: Kume T; Nishikawa H; Tomioka H; Katsuki H; Akaike A; Kaneko S; Maeda T; Kihara T; Shimohama S
p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures.
Brain research 2000;852(2):279-89.
2000: Shimazu S; Katsuki H; Takenaka C; Tomita M; Kume T; Kaneko S; Akaike A
sigma receptor ligands attenuate N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of mesencephalic slice cultures.
European journal of pharmacology 2000;388(2):139-46.
1999: Akaike A; Katsuki H; Kume T; Maeda T
Reactive oxygen species in NMDA receptor-mediated glutamate neurotoxicity.
Parkinsonism & related disorders 1999;5(4):203-7.
1999: Kaneko S; Akaike A; Satoh M
Receptor-mediated modulation of voltage-dependent Ca2+ channels via heterotrimeric G-proteins in neurons.
Japanese journal of pharmacology 1999;81(4):324-31.
1999: Akaike A
[Neuronal response to radical stress]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114(5):273-9.
1999: Imura T; Shimohama S; Sato M; Nishikawa H; Madono K; Akaike A; Kimura J
Differential expression of small heat shock proteins in reactive astrocytes after focal ischemia: possible role of beta-adrenergic receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(22):9768-79.
1999: Katsuki H; Kume T; Kaneko S; Akaike A
[Factors regulating survival and death of midbrain dopamine neurons]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():192P-197P.
1999: Ibi M; Sawada H; Kume T; Katsuki H; Kaneko S; Shimohama S; Akaike A
Depletion of intracellular glutathione increases susceptibility to nitric oxide in mesencephalic dopaminergic neurons.
Journal of neurochemistry 1999;73(4):1696-703.
1999: Shimazu S; Katsuki H; Akaike A
Deprenyl rescues dopaminergic neurons in organotypic slice cultures of neonatal rat mesencephalon from N-methyl-D-aspartate toxicity.
European journal of pharmacology 1999;377(1):29-34.
1999: Kihara T; Shimohama S; Akaike A
Effects of nicotinic receptor agonists on beta-amyloid beta-sheet formation.
Japanese journal of pharmacology 1999;79(3):393-6.
1999: Kaneda K; Kashii S; Kurosawa T; Kaneko S; Akaike A; Honda Y; Minami M; Satoh M
Apoptotic DNA fragmentation and upregulation of Bax induced by transient ischemia of the rat retina.
Brain research 1999;815(1):11-20.
1998: Sawada H; Ibi M; Kihara T; Urushitani M; Akaike A; Shimohama S
Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death.
Journal of neuroscience research 1998;54(5):707-19.
1998: Urushitani M; Shimohama S; Kihara T; Sawada H; Akaike A; Ibi M; Inoue R; Kitamura Y; Taniguchi T; Kimura J
Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection.
Annals of neurology 1998;44(5):796-807.
1998: Kume T; Katsuki H; Kaneko S; Akaike A
[Protective effect of neurotrophin against glutamate neurotoxicity in cortical cultures]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112 Suppl 1():98P-102P.
1998: Adachi K; Kashii S; Masai H; Ueda M; Morizane C; Kaneda K; Kume T; Akaike A; Honda Y
Mechanism of the pathogenesis of glutamate neurotoxicity in retinal ischemia.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 1998;236(10):766-74.
1998: Kinoshita M; Kaneko S; Yasuno T; Yada N; Akaike A; Satoh M
Inhibitory effects of bifemelane on brain Ca2+ channel subtypes expressed in Xenopus oocytes.
Japanese journal of pharmacology 1998;78(1):39-44.
1998: Akaike A; Kume T
[Regulation of neuronal death by endogenous protective factors]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112(3):177-86.
1998: Sawada H; Ibi M; Kihara T; Urushitani M; Akaike A; Kimura J; Shimohama S
Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: mechanisms of neuroprotective treatment against oxidative stress.
Annals of neurology 1998;44(1):110-9.
1998: Maeda T; Ibi M; Shimazu S; Akaike A
Co-culture with the striatum attenuates N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of rat mesencephalic slice cultures.
Japanese journal of pharmacology 1998;77(2):161-7.
1998: Tomita Y; Kaneko S; Funayama M; Kondo H; Satoh M; Akaike A
Intracellular Ca2+ store-operated influx of Ca2+ through TRP-R, a rat homolog of TRP, expressed in Xenopus oocytes.
Neuroscience letters 1998;248(3):195-8.
1998: Nishiyori A; Minami M; Ohtani Y; Takami S; Yamamoto J; Kawaguchi N; Kume T; Akaike A; Satoh M
Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?
FEBS letters 1998;429(2):167-72.
1998: Kikuchi M; Kashii S; Mandai M; Yasuyoshi H; Honda Y; Kaneda K; Akaike A
Protective effects of FK506 against glutamate-induced neurotoxicity in retinal cell culture.
Investigative ophthalmology & visual science 1998;39(7):1227-32.
1998: Adachi K; Fujita Y; Morizane C; Akaike A; Ueda M; Satoh M; Masai H; Kashii S; Honda Y
Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina.
European journal of pharmacology 1998;350(1):53-7.
1998: Sakurai E; Maeda T; Kaneko S; Akaike A; Satoh M
Inhibition by [Arg8]-vasopressin of long term potentiation in guinea pig hippocampal slice.
Japanese journal of pharmacology 1998;77(1):103-5.
1998: Kihara T; Shimohama S; Urushitani M; Sawada H; Kimura J; Kume T; Maeda T; Akaike A
Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity.
Brain research 1998;792(2):331-4.
1998: Akaike A; Maeda T; Kume T; Kaneko S
Bifemelane protects cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.
Japanese journal of pharmacology 1998;76(3):313-6.
1998: Akaike A; Adachi K; Kaneda K
[Techniques for evaluating neuronal death of the retina in vitro and in vivo]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1998;111(2):97-104.
1998: Akaike A; Maeda T; Kaneko S; Tamura Y
Protective effect of MKC-231, a novel high affinity choline uptake enhancer, on glutamate cytotoxicity in cultured cortical neurons.
Japanese journal of pharmacology 1998;76(2):219-22.
1998: Higuchi Y; Hattori H; Kume T; Tsuji M; Akaike A; Furusho K
Increase in nitric oxide in the hypoxic-ischemic neonatal rat brain and suppression by 7-nitroindazole and aminoguanidine.
European journal of pharmacology 1998;342(1):47-9.
1998: Kaneko S; Akaike A; Satoh M
Cut-open recording techniques.
Methods in enzymology 1998;293():319-31.
1998: Kaneko S; Akaike A; Satoh M
Differential regulation of N- and Q-type Ca2+ channels by cyclic nucleotides and G-proteins.
Life sciences 1998;62(17-18):1543-7.
1997: Maeda T; Cheng N; Kume T; Kaneko S; Kouchiyama H; Akaike A; Ueda M; Satoh M; Goshima Y; Misu Y
L-DOPA neurotoxicity is mediated by glutamate release in cultured rat striatal neurons.
Brain research 1997;771(1):159-62.
1997: Kaneko S; Maeda T; Kume T; Kochiyama H; Akaike A; Shimohama S; Kimura J
Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors.
Brain research 1997;765(1):135-40.
1997: Kihara T; Shimohama S; Sawada H; Kimura J; Kume T; Kochiyama H; Maeda T; Akaike A
Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity.
Annals of neurology 1997;42(2):159-63.
1997: Kaneko S; Yada N; Fukuda K; Kikuwaka M; Akaike A; Satoh M
Inhibition of Ca2+ channel current by mu- and kappa-opioid receptors coexpressed in Xenopus oocytes: desensitization dependence on Ca2+ channel alpha 1 subunits.
British journal of pharmacology 1997;121(4):806-12.
1997: Morizane C; Adachi K; Furutani I; Fujita Y; Akaike A; Kashii S; Honda Y
N(omega)-nitro-L-arginine methyl ester protects retinal neurons against N-methyl-D-aspartate-induced neurotoxicity in vivo.
European journal of pharmacology 1997;328(1):45-9.
1997: Kume T; Kouchiyama H; Kaneko S; Maeda T; Kaneko S; Akaike A; Shimohama S; Kihara T; Kimura J; Wada K; Koizumi S
BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons.
Brain research 1997;756(1-2):200-4.
1997: Takami S; Nishikawa H; Minami M; Nishiyori A; Sato M; Akaike A; Satoh M
Induction of macrophage inflammatory protein MIP-1alpha mRNA on glial cells after focal cerebral ischemia in the rat.
Neuroscience letters 1997;227(3):173-6.
1997: Kume T; Kohchiyama H; Nishikawa H; Maeda T; Kaneko S; Akaike A; Noda N; Fujita T
Ether extract of fetal calf serum protects cultured rat cortical neurons against glutamate cytotoxicity.
Japanese journal of pharmacology 1997;73(4):371-4.
1997: Kikuchi M; Kashii S; Honda Y; Tamura Y; Kaneda K; Akaike A
Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture.
Investigative ophthalmology & visual science 1997;38(5):848-54.
1997: Kaneda K; Kikuchi M; Kashii S; Honda Y; Maeda T; Kaneko S; Akaike A
Effects of B vitamins on glutamate-induced neurotoxicity in retinal cultures.
European journal of pharmacology 1997;322(2-3):259-64.
1997: Maeda T; Kaneko S; Akaike A; Satoh M
Direct evidence for increase in excitatory amino acids release during mossy fiber LTP in rat hippocampal slices as revealed by the patch sensor methods.
Neuroscience letters 1997;224(2):103-6.
1997: Shimoshige Y; Maeda T; Kaneko S; Akaike A; Satoh M
Involvement of M2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices.
Neuroscience research 1997;27(2):175-80.
1996: Cheng N; Maeda T; Kume T; Kaneko S; Kochiyama H; Akaike A; Goshima Y; Misu Y
Differential neurotoxicity induced by L-DOPA and dopamine in cultured striatal neurons.
Brain research 1996;743(1-2):278-83.
1996: Sawada H; Shimohama S; Kawamura T; Akaike A; Kitamura Y; Taniguchi T; Kimura J
Mechanism of resistance to NO-induced neurotoxicity in cultured rat dopaminergic neurons.
Journal of neuroscience research 1996;46(4):509-18.
1996: Fukuda K; Kaneko S; Yada N; Kikuwaka M; Akaike A; Satoh M
Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes.
Neuroscience letters 1996;217(1):13-6.
1996: Sakurai E; Maeda T; Kaneko S; Akaike A; Satoh M
Galanin inhibits long-term potentiation at Schaffer collateral-CA1 synapses in guinea-pig hippocampal slices.
Neuroscience letters 1996;212(1):21-4.
1996: Akaike A; Maeda T; Tamura Y
[Experimental techniques for developing new drugs acting on dementia (11)--Experimental methods on glutamate neurotoxicity]
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 1996;16(3):91-6.
1996: Kashii S; Mandai M; Kikuchi M; Honda Y; Tamura Y; Kaneda K; Akaike A
Dual actions of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity in cultured retinal neurons.
Brain research 1996;711(1-2):93-101.
1996: Sawada H; Kawamura T; Shimohama S; Akaike A; Kimura J
Different mechanisms of glutamate-induced neuronal death between dopaminergic and non-dopaminergic neurons in rat mesencephalic culture.
Journal of neuroscience research 1996;43(4):503-10.
1996: Sawada H; Shimohama S; Tamura Y; Kawamura T; Akaike A; Kimura J
Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon.
Journal of neuroscience research 1996;43(1):55-62.
1995: Kikuchi M; Kashii S; Honda Y; Ujihara H; Sasa M; Tamura Y; Akaike A
Protective action of zinc against glutamate neurotoxicity in cultured retinal neurons.
Investigative ophthalmology & visual science 1995;36(10):2048-53.
1995: Maeda T; Shimoshige Y; Mizukami K; Shimohama S; Kaneko S; Akaike A; Satoh M
Patch sensor detection of glutamate release evoked by a single electrical shock.
Neuron 1995;15(2):253-7.
1995: Shimohama S; Akaike A; Tamura Y; Matsushima H; Kume T; Fujimoto S; Takenawa T; Kimura J
Glutamate-induced antigenic changes of phospholipase C-delta in cultured cortical neurons.
Journal of neuroscience research 1995;41(3):418-26.
1995: Ueda M; Oyama T; Kuraishi Y; Akaike A; Satoh M
Alpha 2-adrenoceptor-mediated inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices.
Neuroscience letters 1995;188(2):137-9.
1994: Kaneko S; Nakamura S; Adachi K; Akaike A; Satoh M
Mobilization of intracellular Ca2+ and stimulation of cyclic AMP production by kappa opioid receptors expressed in Xenopus oocytes.
Brain research. Molecular brain research 1994;27(2):258-64.
1994: Kaneko S; Fukuda K; Yada N; Akaike A; Mori Y; Satoh M
Ca2+ channel inhibition by kappa opioid receptors expressed in Xenopus oocytes.
Neuroreport 1994;5(18):2506-8.
1994: Akaike A; Kaneko S; Tamura Y; Nakata N; Shiomi H; Ushikubi F; Narumiya S
Prostaglandin E2 protects cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.
Brain research 1994;663(2):237-43.
1994: Akaike A
[Glutamate neurotoxicity and neuroprotective factors]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1994;103(5):193-201.
1994: Akaike A; Tamura Y; Yokota T; Shimohama S; Kimura J
Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.
Brain research 1994;644(2):181-7.
1994: Kashii S; Takahashi M; Mandai M; Shimizu H; Honda Y; Sasa M; Ujihara H; Tamura Y; Yokota T; Akaike A
Protective action of dopamine against glutamate neurotoxicity in the retina.
Investigative ophthalmology & visual science 1994;35(2):685-95.
1994: Akaike A; Tamura Y; Terada K; Nakata N
Regulation by neuroprotective factors of NMDA receptor mediated nitric oxide synthesis in the brain and retina.
Progress in brain research 1994;103():391-403.
1993: Shimohama S; Tamura Y; Akaike A; Tsukahara T; Ohara O; Watanabe S; Kimura J
Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against glutamate-induced neurotoxicity in cultured rat cortical neurons.
Neuroscience letters 1993;164(1-2):55-8.
1993: Shimohama S; Ogawa N; Tamura Y; Akaike A; Tsukahara T; Iwata H; Kimura J
Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons.
Brain research 1993;632(1-2):296-302.
1993: Akaike A; Tamura Y; Sato Y; Yokota T
Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons.
European journal of pharmacology 1993;241(1):1-6.
1993: Tamura Y; Sato Y; Yokota T; Akaike A; Sasa M; Takaori S
Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons.
The Journal of pharmacology and experimental therapeutics 1993;265(2):1017-25.
1993: Ujihara H; Akaike A; Tamura Y; Yokota T; Sasa M; Kashii S; Honda Y
Blockade of retinal NMDA receptors by sodium nitroprusside is probably due to nitric oxide formation.
Japanese journal of pharmacology 1993;61(4):375-7.
1993: Akaike A; Sasa M; Tamura Y; Ujihara H; Takaori S
Effects of protein kinase C on the muscarinic excitation of rat adrenal chromaffin cells.
Japanese journal of pharmacology 1993;61(2):145-8.
1991: Sasa M; Akaike A; Ohno Y; Hara M; Takaori S
Dopamine D1/D2 receptor interaction.
The Japanese journal of psychiatry and neurology 1991;45(2):507-10.
1990: Akaike A; Mine Y; Sasa M; Takaori S
A patch clamp study of muscarinic excitation of the rat adrenal chromaffin cells.
The Journal of pharmacology and experimental therapeutics 1990;255(1):340-5.
1990: Akaike A; Mine Y; Sasa M; Takaori S
Voltage and current clamp studies of muscarinic and nicotinic excitation of the rat adrenal chromaffin cells.
The Journal of pharmacology and experimental therapeutics 1990;255(1):333-9.
1990: Hirose A; Sasa M; Akaike A; Takaori S
Inhibition of hippocampal CA1 neurons by 5-hydroxytryptamine, derived from the dorsal raphe nucleus and the 5-hydroxytryptamine1A agonist SM-3997.
Neuropharmacology 1990;29(2):93-101.
1989: Ujihara H; Akaike A; Sasa M; Takaori S
Muscarinic regulation of spontaneously active medial vestibular neurons in vitro.
Neuroscience letters 1989;106(1-2):205-10.
1989: Hirose A; Sasa M; Akaike A; Takaori S
[Electroencephalographic study on the central action of a new anxiolytic: 3a alpha, 4 beta, 7 beta, 7a alpha-hexahydro-2-(4-(4-(2-pyrimidinyl)-1- piperazinyl)-butyl)-4, 7-methano-1H-isoindole-1, 3(2H)-dione dihydrogen citrate (SM-3997)]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1989;93(2):41-7.
1988: Ujihara H; Akaike A; Sasa M; Takaori S
Electrophysiological evidence for cholinoceptive neurons in the medial vestibular nucleus: studies on rat brain stem in vitro.
Neuroscience letters 1988;93(2-3):231-5.
1988: Akaike A; Sasa M; Takaori S
Muscarinic inhibition as a dominant role in cholinergic regulation of transmission in the caudate nucleus.
The Journal of pharmacology and experimental therapeutics 1988;246(3):1129-36.
1987: Takatani T; Sasa M; Akaike A; Takaori S
Inhibitory effects of thyrotropin-releasing hormone on neuronal activity in the nucleus accumbens.
Neuropharmacology 1987;26(9):1389-94.
1987: Akaike A; Ohno Y; Sasa M; Takaori S
Excitatory and inhibitory effects of dopamine on neuronal activity of the caudate nucleus neurons in vitro.
Brain research 1987;418(2):262-72.

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