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Wu-Nan Wu

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Wu-Nan Wu; Linda A McKown; Allen B Reitz
Metabolic fate of the antipsychotic agent, mazapertine, in man--API-MS and MS/MS identification of urinary metabolites.
Wu-Nan Wu; Linda A McKown; Allen B Reitz
Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism.
Wu-Nan Wu; Linda A McKown; GH Kuo
Hepatic metabolism of two alpha-1A-adrenergic receptor antagonists, phthalimide-phenylpiperazine analogs (RWJ-69205 and RWJ-69471), in the rat, dog and human.

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All Publications

2007: Wu-Nan Wu; Linda A McKown; Allen B Reitz
Metabolic fate of the antipsychotic agent, mazapertine, in man--API-MS and MS/MS identification of urinary metabolites.
European journal of drug metabolism and pharmacokinetics 2007;32(3):171-6.
2006: Wu-Nan Wu; Linda A McKown; Allen B Reitz
Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism.
European journal of drug metabolism and pharmacokinetics 2006;31(4):277-83.
2006: Wu-Nan Wu; Linda A McKown; GH Kuo
Hepatic metabolism of two alpha-1A-adrenergic receptor antagonists, phthalimide-phenylpiperazine analogs (RWJ-69205 and RWJ-69471), in the rat, dog and human.
European journal of drug metabolism and pharmacokinetics 2006;31(4):271-6.
2006: Ellen E Codd; John R Carson; Raymond W Colburn; Scott L Dax; Daksha Desai-Krieger; Rebecca P Martinez; Linda A McKown; Lou Anne Neilson; Philip M Pitis; P L Stahle; Dennis J Stone; A J Streeter; Wu-Nan Wu; Sui-Po Zhang
The novel, orally active, delta opioid RWJ-394674 is biotransformed to the potent mu opioid RWJ-413216.
The Journal of pharmacology and experimental therapeutics 2006;318(3):1273-9.
2006: Wu-Nan Wu; Linda A McKown; Ellen E Codd; Robert Raffa
Metabolism of two analgesic agents, tramadol-n-oxide and tramadol, in specific pathogen-free and axenic mice.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(6):551-65.
2006: Gary W Caldwell; Wu-Nan Wu; Linda A McKown; A Diane Gauthier; John A Masucci; William J Jones; Gregory C Leo; Allen B Reitz
Distribution and metabolism of the antipsychotic agent mazapertine succinate in rats.
Journal of pharmaceutical and biomedical analysis 2006;41(2):500-9.
2005: Gary W Caldwell; Wu-Nan Wu; John A Masucci; Linda A McKown; D Gauthier; William J Jones; Gregory C Leo; Bruce E Maryanoff
Metabolism and excretion of the antiepileptic/antimigraine drug, Topiramate in animals and humans.
European journal of drug metabolism and pharmacokinetics 2005;30(3):151-64.
2005: Wu-Nan Wu; Linda A McKown; GH Kuo
Metabolism of the new alpha-1A-adrenergic receptor antagonist, phthalimide-phenylpiperazine analog (RWJ-69442), in rat, dog and human hepatic S9 fractions, and in rats.
European journal of drug metabolism and pharmacokinetics 2005;30(1-2):113-20.
2005: Wu-Nan Wu; Linda A McKown; GH Kuo
Metabolism of the alpha-1A-adrenergic receptor antagonist, pyridine-phenylpiperazine analog (RWJ-69597), in rat, dog and human hepatic S9 fractions -API-MS/MS identification of metabolites.
European journal of drug metabolism and pharmacokinetics 2005;30(1-2):105-11.
2004: Wu-Nan Wu; Linda A McKown; Allen B Reitz
Metabolism of the new nonbenzodiazepine anxiolytic agent, RWJ-51204, in mouse, rat, dog, monkey and human hepatic S9 fractions, and in rats, dogs and humans.
European journal of drug metabolism and pharmacokinetics 2004;29(4):263-8.
2004: Wu-Nan Wu; Linda A McKown; Allen B Reitz
Human hepatic metabolism of the anxiolytic agent, RWJ-51521--API-MS/MS identification of metabolites.
European journal of drug metabolism and pharmacokinetics 2004;29(4):257-62.
2004: Wu-Nan Wu; Linda A McKown; Michael D Moyer; W Cheung
Metabolism of the antineoplastic and immunosuppressive drug 2-CdA (Leustatin) in animals and humans.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(6):591-606.
2004: Wu-Nan Wu; Linda A McKown; V Sashi Gopaul
In-vitro metabolism of isotetrandrine, a bisbenzylisoquinoline alkaloid, in rat hepatic S9 fraction by high-performance liquid chromatography-atmospheric pressure ionization mass spectrometry.
The Journal of pharmacy and pharmacology 2004;56(6):749-55.
2004: John R Carson; Steven J Coats; Ellen E Codd; Scott L Dax; Jung Lee; Rebecca P Martinez; Linda A McKown; Lou Anne Neilson; Philip M Pitis; Wu-Nan Wu; Sui-Po Zhang
N-alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, micro and delta opioid agonists: a micro address.
Bioorganic & medicinal chemistry letters 2004;14(9):2113-6.
2004: Wu-Nan Wu; Michael D Moyer
API-ionspray MS and MS/MS study on the structural characterization of bisbenzylisoquinoline alkaloids.
Journal of pharmaceutical and biomedical analysis 2004;34(1):53-66.
2004: Wu-Nan Wu; Michael D Moyer
Electrospray tandem mass spectrometry for structural characterization of aporphine- benzylisoquinoline alkaloids.
European journal of mass spectrometry (Chichester, England) 2004;10(5):683-9.
2003: Wu-Nan Wu; Linda A McKown; Allen B Reitz
Hepatic metabolism of the new antipsychotic agent, mazapertine, in rat--API-MS/MS identification of metabolites.
European journal of drug metabolism and pharmacokinetics 2003;28(4):279-86.
2003: Wu-Nan Wu; Linda A McKown; John L Melton; Allen B Reitz
In-vitro metabolism of the new anxiolytic agent, RWJ-50172, in rat hepatic S9 fraction and microbial transformation in fungi, Cunninghamella sp.
The Journal of pharmacy and pharmacology 2003;55(8):1099-105.
2003: Wu-Nan Wu; Linda A McKown; Philip J Rybczynski; Keith T Demarest
Hepatic biotransformation of the new calcium-mimetic agent, RWJ-68025, in the rat and in man--API-MS/MS identification of metabolites.
The Journal of pharmacy and pharmacology 2003;55(5):631-7.
2003: Wu-Nan Wu; Linda A McKown; John R Carson
In vitro biotransformation of the analgesic agent, RWJ-51784, in rat, dog and human.
European journal of drug metabolism and pharmacokinetics 2003;28(2):107-11.
2003: Wu-Nan Wu; Linda A McKown; John R Carson
In vitro metabolism of the analgesic agent, RWJ-37874, in rat and human.
European journal of drug metabolism and pharmacokinetics 2003;28(2):101-5.
2003: Wu-Nan Wu; Linda A McKown; Allen B Reitz
In vitro metabolism of the new anxiolytic agent, RWJ-52763 in human hepatic S9 fraction-API-MS/MS identification of metabolites.
Journal of pharmaceutical and biomedical analysis 2003;31(1):95-102.
2002: Zhengyin Yan; Gary W Caldwell; Wu-Nan Wu; Linda A McKown; Bryan M Rafferty; W Jones; John A Masucci
In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(11):949-62.
2002: Alfonzo D Jordan; Anil Vaidya; Daniel I Rosenthal; Barry Dubinsky; Cheryl P Kordik; Pauline J Sanfilippo; Wu-Nan Wu; Allen B Reitz
Potential anxiolytic agents. Part 4: novel orally-active N(5)-substituted pyrido[1,2-a]benzimidazoles with high GABA-A receptor affinity.
Bioorganic & medicinal chemistry letters 2002;12(17):2381-6.
2002: Wu-Nan Wu; Linda A McKown
The in vitro metabolism of thalicarpine, an aporphine-benzyltetrahydroisoquinoline alkaloid, in the rat. API-MS/MS identification of thalicarpine and metabolites.
Journal of pharmaceutical and biomedical analysis 2002;30(1):141-50.
2002: Wu-Nan Wu; Linda A McKown; Ellen E Codd; Robert Raffa
In vitro metabolism of the analgesic agent, tramadol-N-oxide, in mouse, rat, and human.
European journal of drug metabolism and pharmacokinetics 2002;27(3):193-7.
2002: Wu-Nan Wu; G W Caldwell; John A Masucci
Evaluation of the excretion and metabolism of the new analgesic agent RWJ-22757 in male and female CR Wistar rats.
Journal of pharmaceutical and biomedical analysis 2002;28(3-4):659-71.
2002: Wu-Nan Wu; Linda A McKown; S Liao
Metabolism of the analgesic drug ULTRAM (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(5):411-25.
2001: G W Caldwell; Wu-Nan Wu; John A Masucci
Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man.
Xenobiotica; the fate of foreign compounds in biological systems 2001;31(11):823-39.
2001: Wu-Nan Wu; G W Caldwell; John A Masucci; A D Gauthier
Evaluation of the excretion, and metabolism of the cardiotonic agent bemoradan in male rats and female beagle dogs.
European journal of drug metabolism and pharmacokinetics 2001;26(4):263-71.
2001: Wu-Nan Wu; G W Caldwell; John A Masucci
Evaluation of the absorption, excretion, and metabolism of the antihypertensive agent RWJ-26899 in male and female CR Wistar rats and Beagle dogs.
European journal of drug metabolism and pharmacokinetics 2001;26(3):155-66.
2001: Wu-Nan Wu; Linda A McKown; A D Gauthier; William J Jones; Robert Raffa
Metabolism of the analgesic drug, tramadol hydrochloride, in rat and dog.
Xenobiotica; the fate of foreign compounds in biological systems 2001;31(7):423-41.
2000: Wu-Nan Wu; Linda A McKown; Michael D Moyer; Allen B Reitz
In vitro biotransformation of the new antipsychotic agent, RWJ-46344 in rat hepatic S9 fraction: API-MS/MS/MS identification of metabolites.
Journal of pharmaceutical and biomedical analysis 2000;24(2):307-16.
2000: Wu-Nan Wu; Linda A McKown
Recent advances in biotransformation of CNS and cardiovascular agents.
Current drug metabolism 2000;1(3):255-70.
1999: Wu-Nan Wu; Linda A McKown; Michael D Moyer; T B Johannsen; A R Takacs
In vitro metabolism of mifepristone (RU-486) in rat, monkey and human hepatic S9 fractions: identification of three new mifepristone metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(11):1089-100.
1999: Wu-Nan Wu; Linda A McKown; K A Yorgey; J F Pritchard
In vitro metabolic products of RWJ-34130, an antiarrythmic agent, in rat liver preparations.
Journal of pharmaceutical and biomedical analysis 1999;20(4):687-95.
1999: Wu-Nan Wu; Linda A McKown; A R Takacs; William J Jones; Allen B Reitz
Biotransformation of the antipsychotic agent, mazapertine, in dog--mass spectral characterization and identification of metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(5):453-66.
1998: Wu-Nan Wu; John A Masucci; G W Caldwell
Biotransformation of an antihypertensive arylalkylamine analogue in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1998;28(10):957-72.
1998: Wu-Nan Wu
Metabolic fate of the hypoglycemic agent pirogliride in laboratory animals and humans.
Journal of pharmaceutical and biomedical analysis 1998;17(4-5):689-97.
1998: Wu-Nan Wu; John A Masucci; G W Caldwell; John R Carson
Excretion and metabolism of the antihypertensive agent, RWJ-26240 (McN-5691) in dogs.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(2):115-25.
1997: Samuel O Nortey; Wu-Nan Wu; Bruce E Maryanoff
Synthesis of hydroxylated derivatives of topiramate, a novel antiepileptic drug based on D-fructose: investigation of oxidative metabolites.
Carbohydrate research 1997;304(1):29-38.
1996: Robert Raffa; M L Haslego; C A Maryanoff; F J Villani; Ellen E Codd; CD Connelly; R P Martinez; J J Schupsky; J A Buben; Wu-Nan Wu; A N Takacs; Linda A McKown
Unexpected antinociceptive effect of the N-oxide (RWJ 38705) of tramadol hydrochloride.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1098-104.
1995: Wu-Nan Wu; M S Mutter
Biotransformation of linogliride, a hypoglycemic agent in laboratory animals and humans.
Journal of pharmaceutical and biomedical analysis 1995;13(7):857-67.
1995: Wu-Nan Wu; John A Masucci; Linda A McKown; J D Rodgers
Identification of four plasma metabolites of Etoperidone in dogs.
Journal of pharmaceutical and biomedical analysis 1995;13(2):177-84.
1995: Wu-Nan Wu; Linda A McKown; P J O'Neill
In vitro and in vivo metabolism of the antianxiolytic agent fenobam in the rat.
Journal of pharmaceutical sciences 1995;84(2):185-9.
1994: Wu-Nan Wu; J F Hills; S Y Chang
In vivo biotransformation of fenoctimine in rat, dog and man.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(11):1133-48.
1994: Wu-Nan Wu; J F Hills; R S Egan
Metabolism of xilobam in laboratory animals and man.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(7):649-62.
1994: Linda A McKown; Wu-Nan Wu; P J O'Neill
Characterization and identification of the metabolites of fenoctimine using in vitro drug metabolizing systems.
Journal of pharmaceutical and biomedical analysis 1994;12(6):771-5.
1994: Wu-Nan Wu; John A Masucci
Identification of two new suprofen metabolites in human urine.
Journal of pharmaceutical and biomedical analysis 1994;12(4):569-71.
1992: Wu-Nan Wu; J F Pritchard; K T Ng; J F Hills; J A Uetz; K A Yorgey; Linda A McKown; P J O'Neill
Disposition of bepridil in laboratory animals and man.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(2):153-69.
1988: Wu-Nan Wu; J F Hills; S Y Chang; K T Ng
Metabolism of bepridil in laboratory animals and humans.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(1):69-77.
1980: Wu-Nan Wu; L E Weaner; J Kalbron; P J O'Neill; J M Grindel
The metabolism of zomepirac sodium. II. Isolation and identification of the urinary metabolites in rat, mouse, rhesus monkey, and man.
Drug metabolism and disposition: the biological fate of chemicals 1980;8(5):349-52.
1980: J M Grindel; P J O'Neill; K A Yorgey; M H Schwartz; Linda A McKown; B H Migdalof; Wu-Nan Wu
The metabolism of zomepirac sodium. I. Disposition in laboratory animals and man.
Drug metabolism and disposition: the biological fate of chemicals 1980;8(5):343-8.