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Makoto Akaike

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Hiroshi Tamagawa; Kazuhito Tuschida; Takuo Watanabe; Naoto Yamamoto; Kazue Yoshihara; Munetaka Masuda; Soichiro Morinaga; Masakatsu Numata; Takashi Oshima; Manabu Shiozawa; Makoto Akaike; Toshio lmada
The expression of the phosphatase regenerating liver 3 gene is associated with outcome in patients with colorectal cancer.
Soichiro Morinaga; Yoshiyasu Nakamura; Shinnichi Ohkawa; Manabu Shiozawa; Hiroshi Tamagawa; Takuo Watanabe; Naoto Yamamoto; Makoto Akaike; Yoichi Kameda; Hiroshi Mikayama; Yohei Miyagi
Immunohistochemical analysis of human equilibrative nucleoside transporter-1 (hENT1) predicts survival in resected pancreatic cancer patients treated with adjuvant gemcitabine monotherapy.
Hiroshi Tamagawa; Naoto Yamamoto; Makoto Akaike; Yoichi Kameda; Munetaka Masuda; Yohei Miyagi; Soichiro Morinaga; Masakatsu Numata; Yuji Sakuma; Hironobu Sekiguchi; Akiko Sekiyama; Manabu Shiozawa; Toshio Imada
Comparison of the chemosensitivity of the primary lesion and a pancreatic metastasis of colon cancer: a case report.

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All Publications

2012: Hiroshi Tamagawa; Kazuhito Tuschida; Takuo Watanabe; Naoto Yamamoto; Kazue Yoshihara; Munetaka Masuda; Soichiro Morinaga; Masakatsu Numata; Takashi Oshima; Manabu Shiozawa; Makoto Akaike; Toshio lmada
The expression of the phosphatase regenerating liver 3 gene is associated with outcome in patients with colorectal cancer.
Hepato-gastroenterology 2012;59(119):2122-6.
2012: Soichiro Morinaga; Yoshiyasu Nakamura; Shinnichi Ohkawa; Manabu Shiozawa; Hiroshi Tamagawa; Takuo Watanabe; Naoto Yamamoto; Makoto Akaike; Yoichi Kameda; Hiroshi Mikayama; Yohei Miyagi
Immunohistochemical analysis of human equilibrative nucleoside transporter-1 (hENT1) predicts survival in resected pancreatic cancer patients treated with adjuvant gemcitabine monotherapy.
Annals of surgical oncology 2012;19 Suppl 3():S558-64.
2012: Hiroshi Tamagawa; Naoto Yamamoto; Makoto Akaike; Yoichi Kameda; Munetaka Masuda; Yohei Miyagi; Soichiro Morinaga; Masakatsu Numata; Yuji Sakuma; Hironobu Sekiguchi; Akiko Sekiyama; Manabu Shiozawa; Toshio Imada
Comparison of the chemosensitivity of the primary lesion and a pancreatic metastasis of colon cancer: a case report.
Anticancer research 2012;32(4):1457-61.
2011: Naoto Yamamoto; Daisuke Inagaki; Amane Kanazawa; Soichiro Morinaga; Yasushi Rino; Manabu Shiozawa; Nobuhiro Sugano; Makoto Akaike
Massive portal vein tumor thrombus from colorectal cancer without any metastatic nodules in the liver parenchyma.
Rare tumors 2011;3(4):e47.
2011: Masakatsu Numata; Takashi Oshima; Yasushi Rino; Manabu Shiozawa; Hiroshi Tamagawa; Katsuaki Tanaka; Kazuhito Tsuchida; Takuo Watanabe; Naoto Yamamoto; Kazue Yoshihara; Makoto Akaike; Chikara Kunisaki; Munetaka Masuda; Soichiro Morinaga; Toshio Imada
Relationship between RegIV gene expression to outcomes in colorectal cancer.
Journal of surgical oncology 2011;104(2):205-9.
2011: Takashi Oshima; Seiich Takenoshita; Makoto Akaike; Chikara Kunisaki; Shoich Fujii; Akito Nozaki; Kazushi Numata; Manabu Shiozawa; Yasushi Rino; Katsuaki Tanaka; Munetaka Masuda; Toshio Imada
Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer.
Oncology reports 2011;25(5):1439-46.
2011: Shuzo Tamura; Takashi Oshima; Kazue Yoshihara; Amane Kanazawa; Takanobu Yamada; Daisuke Inagaki; Tsutomu Sato; Naoto Yamamoto; Manabu Shiozawa; Soichiro Morinaga; Makoto Akaike; Chikara Kunisaki; Katsuaki Tanaka; Munetaka Masuda; Toshio Imada
Clinical significance of STC1 gene expression in patients with colorectal cancer.
Anticancer research 2011;31(1):325-9.
2010: Amane Kanazawa; Takashi Oshima; Kazue Yoshihara; Shuzo Tamura; Takanobu Yamada; Daisuke Inagaki; Tsutomu Sato; Naoto Yamamoto; Manabu Shiozawa; Soichiro Morinaga; Makoto Akaike; Chikara Kunisaki; Katsuaki Tanaka; Munetaka Masuda; Toshio Imada
Relation of MT1-MMP gene expression to outcomes in colorectal cancer.
Journal of surgical oncology 2010;102(6):571-5.
2010: Daisuke Inagaki; Takashi Oshima; Kazue Yoshihara; Shuzo Tamura; Amane Kanazawa; Takanobu Yamada; Naoto Yamamoto; Tsutomu Sato; Manabu Shiozawa; Soichiro Morinaga; Makoto Akaike; Shoichi Fujii; Kazushi Numata; Chikara Kunisaki; Yasushi Rino; Katsuaki Tanaka; Munetaka Masuda; Toshio Imada
Overexpression of tissue inhibitor of metalloproteinase-1 gene correlates with poor outcomes in colorectal cancer.
Anticancer research 2010;30(10):4127-30.
2010: Amane Kanazawa; Manabu Shiozawa; Daisuke Inagaki; Soichiro Morinaga; Yukio Sugimasa; Takashi Oshima; Yasushi Rino; Munetaka Masuda; Toshio Imada; Makoto Akaike
Risk factors for intrahepatic recurrence after curative surgical treatment of colorectal liver metastases.
Hepato-gastroenterology 2010;57(102-103):1183-6.
2010: Takanobu Yamada; Takashi Oshima; Kazue Yoshihara; Shuzo Tamura; Amane Kanazawa; Daisuke Inagaki; Naoto Yamamoto; Tsutomu Sato; Shoichi Fujii; Kazushi Numata; Chikara Kunisaki; Manabu Shiozawa; Soichiro Morinaga; Makoto Akaike; Yasushi Rino; Katsuaki Tanaka; Munetaka Masuda; Toshio Imada
Overexpression of MMP-13 gene in colorectal cancer with liver metastasis.
Anticancer research 2010;30(7):2693-9.
2010: Norio Yukawa; Yuji Yamamoto; Makoto Akaike; Manabu Shiozawa; Makoto Takahashi; Ryuji Shiraishi; Hiroshi Matsukawa; Hiroharu Suzuki; Isao Tamura; Yukihiro Ozawa; N Yamamoto; Yasushi Rino; Munetaka Masuda; Toshio Imada
[Modified FOLFIRI (l-LV, 5-fluorouracil and irinotecan) therapy for Japanese patients with metastatic colorectal cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 2010;37(7):1291-5.
2010: Nobuhiro Sugano; Tetsuji Suda; Ten-I Godai; Kazuhito Tsuchida; Manabu Shiozawa; Hironobu Sekiguchi; Mitsuyo Yoshihara; Shoichi Matsukuma; Yuji Sakuma; Eiju Tsuchiya; Yoichi Kameda; Makoto Akaike; Yohei Miyagi
MDM2 gene amplification in colorectal cancer is associated with disease progression at the primary site, but inversely correlated with distant metastasis.
Genes, chromosomes & cancer 2010;49(7):620-9.
2009: N Yamamoto; Takashi Oshima; Kazue Yoshihara; Tsutomu Sato; Roppei Yamada; Shoichi Fujii; Yasuhiko Nagano; Manabu Shiozawa; Makoto Akaike; Nobuyuki Wada; Yasushi Rino; Chikara Kunisaki; Munetaka Masuda; Katsuaki Tanaka; Toshio Imada
Reduced expression of the AdipoR1 gene is correlated with venous invasion in colorectal cancer.
Molecular medicine reports 2009;2(4):555-9.
2009: Manabu Shiozawa; Nobuhiro Sugano; Kazuhito Tsuchida; Soichiro Morinaga; Makoto Akaike; Yukio Sugimasa
A phase I study of combination therapy with S-1 and irinotecan (CPT-11) in patients with advanced colorectal cancer.
Journal of cancer research and clinical oncology 2009;135(3):365-70.
2009: Ten-i Godai; Tetsuji Suda; Nobuhiro Sugano; Kazuhito Tsuchida; Manabu Shiozawa; Hironobu Sekiguchi; Akiko Sekiyama; Mitsuyo Yoshihara; Shoichi Matsukuma; Yuji Sakuma; Eiju Tsuchiya; Yoichi Kameda; Makoto Akaike; Yohei Miyagi
Identification of colorectal cancer patients with tumors carrying the TP53 mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy.
BMC cancer 2009;9():420.
2008: Takashi Oshima; Makoto Akaike; Kazue Yoshihara; Manabu Shiozawa; Naoto Yamamoto; Tsutomu Sato; Nozaki Akihito; Yasuhiko Nagano; Shoich Fujii; Chikara Kunisaki; Nobuyuki Wada; Yasushi Rino; Katsuaki Tanaka; Munetaka Masuda; Toshio Imada
Overexpression of EphA4 gene and reduced expression of EphB2 gene correlates with liver metastasis in colorectal cancer.
International journal of oncology 2008;33(3):573-7.
2008: Soichiro Morinaga; Yuji Yamamoto; Nobuhiro Sugano; Hiroo Wada; Manabu Shiozawa; Makoto Akaike; Yukio Sugimasa
Long-term survival after multimodal therapy in a patient demonstrating intrahepatic cholangiocarcinoma with hilar invasion and intrahepatic metastases.
International journal of clinical oncology 2008;13(4):361-4.
2008: Takashi Oshima; Makoto Akaike; Kazue Yoshihara; Manabu Shiozawa; Naoto Yamamoto; Tsutomu Sato; Roppei Yamada; Shoich Fujii; Yasushi Rino; Chikara Kunisaki; Katsuaki Tanaka; Munetaka Masuda; Toshio Imada
Clinicopathological significance of the gene expression of matrix metalloproteinase-7, insulin-like growth factor-1, insulin-like growth factor-2 and insulin-like growth factor-1 receptor in patients with colorectal cancer: insulin-like growth factor-1 receptor gene expression is a useful predictor of liver metastasis from colorectal cancer.
Oncology reports 2008;20(2):359-64.
2008: Kazuhito Tsuchida; Manabu Shiozawa; Nobuhiro Sugano; Soichiro Morinaga; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya; Yoichi Kameda; Yasushi Rino; Toshio Imada
[Case of GIST of the rectum successfully treated with imatinib mesylate neoadjuvant therapy].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2008;105(6):830-5.
2008: Takashi Oshima; Chikara Kunisaki; Kazue Yoshihara; Roppei Yamada; Naoto Yamamoto; Tsutomu Sato; Hirochika Makino; Shigeru Yamagishi; Yasuhiko Nagano; Shoich Fujii; Manabu Shiozawa; Makoto Akaike; Nobuyuki Wada; Yasushi Rino; Munetaka Masuda; Katsuaki Tanaka; Toshio Imada
Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer.
Oncology reports 2008;19(5):1285-91.
2008: Takashi Oshima; Chikara Kunisaki; Kazue Yoshihara; Roppei Yamada; Naoto Yamamoto; Tsutomu Sato; Hirochika Makino; Shigeru Yamagishi; Yasuhiko Nagano; Shoich Fujii; Manabu Shiozawa; Makoto Akaike; Nobuyuki Wada; Yasushi Rino; Munetaka Masuda; Katsuaki Tanaka; Toshio Imada
Reduced expression of the claudin-7 gene correlates with venous invasion and liver metastasis in colorectal cancer.
Oncology reports 2008;19(4):953-9.
2007: Soichiro Morinaga; Kazuo Tarao; Yuji Yamamoto; Yoshiyasu Nakamura; Yasushi Rino; Kaoru Miyakawa; Shinichi Ohkawa; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya
Overexpressed cyclo-oxygenase-2 in the background liver is associated with the clinical course of hepatitis C virus-related cirrhosis patients after curative surgery for hepatocellular carcinoma.
Journal of gastroenterology and hepatology 2007;22(8):1249-55.
2007: Hiroyuki Saeki; Shunsuke Yanoma; Shoji Takemiya; Yukio Sugimasa; Makoto Akaike; Norio Yukawa; Yasushi Rino; Toshio Imada
Antitumor activity of a combination of trastuzumab (Herceptin) and oral fluoropyrimidine S-1 on human epidermal growth factor receptor 2-overexpressing pancreatic cancer.
Oncology reports 2007;18(2):433-9.
2007: Manabu Shiozawa; Makoto Akaike; Roppei Yamada; Teni Godai; Naoto Yamamoto; Hiroshige Saito; Yukio Sugimasa; Shoji Takemiya; Yasushi Rino; Toshio Imada
Lateral lymph node dissection for lower rectal cancer.
Hepato-gastroenterology 2007;54(76):1066-70.
2007: Norio Yukawa; Takaki Yoshikawa; Makoto Akaike; Yukio Sugimasa; Yasushi Rino; Munetaka Masuda; Toshio Imada
Impact of plasma tissue inhibitor of matrix metalloproteinase-1 on long-term survival in patients with colorectal cancer.
Oncology 2007;72(3-4):205-8.
2007: Manabu Shiozawa; Makoto Akaike; Roppei Yamada; Teni Godai; Naoto Yamamoto; Hiroshige Saito; Yukio Sugimasa; Shoji Takemiya; Yasushi Rino; Toshio Imada
Clinicopathological features of skip metastasis in colorectal cancer.
Hepato-gastroenterology 2007;54(73):81-4.
2006: Kazuhito Tsuchida; Soichiro Morinaga; Nobuhiro Sugano; Manabu Shiozawa; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya; Hiroyuki Hayashi; Yasushi Rino; Toshio Imada
[A case of flat elevated type carcinoma in adenoma of the duodenum with gastric cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 2006;33(12):1878-80.
2006: Roppei Yamada; Shunsuke Yanoma; Makoto Akaike; Akira Tsuburaya; Yukio Sugimasa; Shoji Takemiya; Hisahiko Motohashi; Yasushi Rino; Yoshinori Takanashi; Toshio Imada
Water-generated negative air ions activate NK cell and inhibit carcinogenesis in mice.
Cancer letters 2006;239(2):190-7.
2005: Soichiro Morinaga; Naoki Ishiwa; Yoshikazu Noguchi; Yuji Yamamoto; Yasushi Rino; Toshio Imada; Yoshinori Takanashi; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya
Growth index, assessed with Ki-67 and ssDNA labeling; a significant prognosticator for patients undergoing curative resection for hepatocellular carcinoma.
Journal of surgical oncology 2005;92(4):331-6.
2004: Soichiro Morinaga; Yoshiyasu Nakamura; Naoki Ishiwa; Takaki Yoshikawa; Yoshikazu Noguchi; Yuji Yamamoto; Yasushi Rino; Toshio Imada; Yoshinori Takanashi; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya
Expression of survivin mRNA associates with apoptosis, proliferation and histologically aggressive features in hepatocellular carcinoma.
Oncology reports 2004;12(6):1189-94.
2004: Norio Yukawa; Takaki Yoshikawa; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya; Shunsuke Yanoma; Toshio Imada; Yoshikazu Noguchi
Prognostic impact of tissue inhibitor of matrix metalloproteinase-1 in plasma of patients with colorectal cancer.
Anticancer research 2004;24(3b):2101-5.
2003: Soichiro Morinaga; Yuji Yamamoto; Yoshikazu Noguchi; Toshio Imada; Yasushi Rino; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya; Yoshinori Takanashi
Platelet-derived endothelial cell growth factor (PD-ECGF) is up-regulated in human hepatocellular carcinoma (HCC) and the corresponding hepatitis liver.
Hepato-gastroenterology 2003;50(53):1521-6.
2002: Hiroyuki Saeki; Yukio Sugimasa; Roppei Yamada; Makoto Akaike; Shoji Takemiya; Takahiro Masaki; Kaoru Miyagawa; Shinichi Okawa
[Intraoperative radiotherapy (IORT) for unresectable stage IVb pancreatic cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29(12):2221-3.
2002: Shinichi Ohkawa; Satoru Hirokawa; Takahiro Masaki; Kaoru Miyakawa; Kazuo Tarao; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya; Motonori Sairenji; Hisahiko Motohashi
[Examination of percutaneous microwave coagulation and radiofrequency ablation therapy for metastatic liver cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 2002;29(12):2149-51.
2002: Soichiro Morinaga; Yuji Yamamoto; Yoshikazu Noguchi; Toshio Imada; Yasushi Rino; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya; Yoichi Kameda; Yoshinori Takanashi
Cyclooxygenase-2 mRNA is up-regulated in cirrhotic or chronic hepatitis liver adjacent to hepatocellular carcinoma.
Journal of gastroenterology and hepatology 2002;17(10):1110-6.
2001: Norio Yukawa; Takaki Yoshikawa; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya; Shunsuke Yanoma; Yoshikazu Noguchi; Yoshinori Takanashi
Plasma concentration of tissue inhibitor of matrix metalloproteinase 1 in patients with colorectal carcinoma.
The British journal of surgery 2001;88(12):1596-601.
2001: Norio Yukawa; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya; Hisahiko Motohashi
[Therapeutic strategy for hepatic metastasis of primary colon cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(11):1565-8.
2001: Soichiro Morinaga; Toshio Imada; A Shimizu; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya; Yoshinori Takanashi
Angiogenesis in hepatocellular carcinoma as evaluated by alpha smooth muscle actin immunohistochemistry.
Hepato-gastroenterology 2001;48(37):224-8.
1999: A Miyamatsu; Soichiro Morinaga; Norio Yukawa; Makoto Akaike; Yukio Sugimasa; Shoji Takemiya
[Intraoperative radiation therapy (IORT) for locally unresectable pancreatic cancer].
Gan to kagaku ryoho. Cancer & chemotherapy 1999;26(12):1846-8.
1998: Youkatsu Ohhama; Masato Shinkai; Shogo Fujita; Toshiji Nishi; H Yamamoto; K Torigai; A Satoh; Shoji Takemiya; Yukio Sugimasa; Makoto Akaike; H Tanabe
The first cooperative living-related donor liver transplantation performed by two separate institution teams: The Kanagawa Liver Transplantation Program.
Surgery today 1998;28(2):173-7.
1997: Kazuo Tarao; Shoji Takemiya; Setsuo Tamai; Yukio Sugimasa; Shinichi Ohkawa; Makoto Akaike; H Tanabe; A Shimizu; Muneki Yoshida; Akira Kakita
Relationship between the recurrence of hepatocellular carcinoma (HCC) and serum alanine aminotransferase levels in hepatectomized patients with hepatitis C virus-associated cirrhosis and HCC.
Cancer 1997;79(4):688-94.
1994: Kazuo Tarao; H Hoshino; A Shimizu; Shinichi Ohkawa; Y Nakamura; M Harada; Y Ito; Setsuo Tamai; Makoto Akaike; Yukio Sugimasa
Role of increased DNA synthesis activity of hepatocytes in multicentric hepatocarcinogenesis in residual liver of hepatectomized cirrhotic patients with hepatocellular carcinoma.
Japanese journal of cancer research : Gann 1994;85(10):1040-4.