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Kenneth Breslauer

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Occupations

Thermodynamics

Concepts & Ideas

Chemicals & Drugs

Phenomena

Procedures

Disorders

DNA Damage

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Co-Publications
Name
23
Plum, Eric
15
Völker, Jens
14
Pilch, Daniel
13
Chalikian, Tigran
7
Gelfand, Craig
7
Grollman, Arthur
7
Klump, Horst
7
Olson, Wilma
5
Remeta, David
4
Minetti, Conceicao
4
LaVoie, Edmond
4
Liu, Leroy
4
Erie, Dorothy
2
Dervan, Peter
2
Hogan, ME

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Publications

TOP 3
Völker Jens; Plum G Eric; Klump Horst H; Breslauer Kenneth J
DNA repair and DNA triplet repeat expansion: the impact of abasic lesions on triplet repeat DNA energetics.
Johnson Matthew D; Völker Jens; Moeller Holly V; Laws Edward; Breslauer Kenneth J; Falkowski Paul G
Universal constant for heat production in protists.
Völker Jens; Klump Horst H; Breslauer Kenneth J
DNA energy landscapes via calorimetric detection of microstate ensembles of metastable macrostates and triplet repeat diseases.

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All Publications

2009: Völker Jens; Plum G Eric; Klump Horst H; Breslauer Kenneth J
DNA repair and DNA triplet repeat expansion: the impact of abasic lesions on triplet repeat DNA energetics.
Journal of the American Chemical Society 2009;131(26):9354-60.
2009: Johnson Matthew D; Völker Jens; Moeller Holly V; Laws Edward; Breslauer Kenneth J; Falkowski Paul G
Universal constant for heat production in protists.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(16):6696-9.
2008: Völker Jens; Klump Horst H; Breslauer Kenneth J
DNA energy landscapes via calorimetric detection of microstate ensembles of metastable macrostates and triplet repeat diseases.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18326-30.
2008: Minetti Conceição A S A; Remeta David P; Breslauer Kenneth J
A continuous hyperchromicity assay to characterize the kinetics and thermodynamics of DNA lesion recognition and base excision.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):70-5.
2007: Lee Benjamin J; Barch Maryan; Castner Edward W; Völker Jens; Breslauer Kenneth J
Structure and dynamics in DNA looped domains: CAG triplet repeat sequence dynamics probed by 2-aminopurine fluorescence.
Biochemistry 2007;46(38):10756-66.
2007: Völker Jens; Klump Horst H; Breslauer Kenneth J
The energetics of i-DNA tetraplex structures formed intermolecularly by d(TC5) and intramolecularly by d[(C5T3)3C5].
Biopolymers 2007;86(2):136-47.
2007: Völker Jens; Klump Horst H; Breslauer Kenneth J
DNA metastability and biological regulation: conformational dynamics of metastable omega-DNA bulge loops.
Journal of the American Chemical Society 2007;129(16):5272-80.
2007: Plum G Eric; Breslauer David N; Breslauer Kenneth J
High resolution protein-DNA binding energy landscapes via a novel high throughput method.
Biopolymers 2007;85(5-6):vii-viii.
2007: Breslauer Kenneth J
Julian Sturtevant: scientific giant, warm humanist, social activist, nature lover, gentle teacher, kind friend.
Biophysical chemistry 2007;126(1-3):9-10.
2007: Privalov Peter L; Dragan Anatoly I; Crane-Robinson Colyn; Breslauer Kenneth J; Remeta David P; Minetti Conceição A S A
What drives proteins into the major or minor grooves of DNA?
Journal of molecular biology 2007;365(1):1-9.
2005: Völker Jens; Breslauer Kenneth J
Communication between noncontacting macromolecules.
Annual review of biophysics and biomolecular structure 2005;34():21-42.
2004: Braunlin William H; Giri Indrajit; Beadling Les; Breslauer Kenneth J
Conformational screening of oligonucleotides by variable-temperature high performance liquid chromatography: dissecting the duplex-hairpin-coil equilibria of d(CGCGAATTCGCG).
Biopolymers 2004;74(3):221-31.
2003: Minetti Conceição A S A; Remeta David P; Miller Holly; Gelfand Craig A; Plum G Eric; Grollman Arthur P; Breslauer Kenneth J
The thermodynamics of template-directed DNA synthesis: base insertion and extension enthalpies.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14719-24.
2003: Minetti Conceição A S A; Remeta David P; Zharkov Dmitry O; Plum G Eric; Johnson Francis; Grollman Arthur P; Breslauer Kenneth J
Energetics of lesion recognition by a DNA repair protein: thermodynamic characterization of formamidopyrimidine-glycosylase (Fpg) interactions with damaged DNA duplexes.
Journal of molecular biology 2003;328(5):1047-60.
2002: Völker J; Makube N; Plum G E; Klump H H; Breslauer K J
Conformational energetics of stable and metastable states formed by DNA triplet repeat oligonucleotides: implications for triplet expansion diseases.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):14700-5.
2001: Völker J; Klump H H; Manning G S; Breslauer K J
Counterion association with native and denatured nucleic acids: an experimental approach.
Journal of molecular biology 2001;310(5):1011-25.
2001: Völker J; Klump H H; Breslauer K J
Communication between noncontacting macromolecules.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7694-9.
2001: Plum G E; Breslauer K J
Fluorescence energy transfer monitored competitive equilibria of nucleic acids: applications in thermodynamics and screening.
Biopolymers 2001;61(3):214-23.
2000: Pilch D S; Dunham S U; Jamieson E R; Lippard S J; Breslauer K J
DNA sequence context modulates the impact of a cisplatin 1,2-d(GpG) intrastrand cross-link on the conformational and thermodynamic properties of duplex DNA.
Journal of molecular biology 2000;296(3):803-12.
1999: Chalikian T V; Völker J; Srinivasan A R; Olson W K; Breslauer K J
The hydration of nucleic acid duplexes as assessed by a combination of volumetric and structural techniques.
Biopolymers 1999;50(5):459-71.
1999: Völker J; Blake R D; Delcourt S G; Breslauer K J
High-resolution calorimetric and optical melting profiles of DNA plasmids: resolving contributions from intrinsic melting domains and specifically designed inserts.
Biopolymers 1999;50(3):303-18.
1999: Chalikian T V; Völker J; Plum G E; Breslauer K J
A more unified picture for the thermodynamics of nucleic acid duplex melting: a characterization by calorimetric and volumetric techniques.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7853-8.
1999: Gelfand C A; Plum G E; Mielewczyk S; Remeta D P; Breslauer K J
A quantitative method for evaluating the stabilities of nucleic acids.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6113-8.
1999: Yu C; Mielewczyk S S; Breslauer K J; Kohn J
Tyrosine-PEG-derived poly(ether carbonate)s as new biomaterials. Part II: study of inverse temperature transitions.
Biomaterials 1999;20(3):265-72.
1999: Pilch D S; Poklar N; Baird E E; Dervan P B; Breslauer K J
The thermodynamics of polyamide-DNA recognition: hairpin polyamide binding in the minor groove of duplex DNA.
Biochemistry 1999;38(7):2143-51.
1999: Plum G E; Gelfand C A; Breslauer K J
Effects of 3,N4-ethenodeoxycytidine on duplex stability and energetics.
IARC scientific publications 1999;(150):169-77.
1998: Chalikian T V; Gindikin V S; Breslauer K J
Hydration of diglycyl tripeptides with non-polar side chains: a volumetric study.
Biophysical chemistry 1998;75(1):57-71.
1998: Chalikian T V; Breslauer K J
Thermodynamic analysis of biomolecules: a volumetric approach.
Current opinion in structural biology 1998;8(5):657-64.
1998: Gelfand C A; Plum G E; Grollman A P; Johnson F; Breslauer K J
The impact of an exocyclic cytosine adduct on DNA duplex properties: significant thermodynamic consequences despite modest lesion-induced structural alterations.
Biochemistry 1998;37(36):12507-12.
1998: Gelfand C A; Plum G E; Grollman A P; Johnson F; Breslauer K J
Thermodynamic consequences of an abasic lesion in duplex DNA are strongly dependent on base sequence.
Biochemistry 1998;37(20):7321-7.
1998: Xu Z; Li T K; Kim J S; LaVoie E J; Breslauer K J; Liu L F; Pilch D S
DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazoles.
Biochemistry 1998;37(10):3558-66.
1998: Chalikian T V; Breslauer K J
Volumetric properties of nucleic acids.
Biopolymers 1998;48(4):264-80.
1997: Pilch D S; Xu Z; Sun Q; LaVoie E J; Liu L F; Breslauer K J
A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: a potential mechanism for topoisomerase I poisoning.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13565-70.
1997: Chalikian T V; Völker J; Anafi D; Breslauer K J
The native and the heat-induced denatured states of alpha-chymotrypsinogen A: thermodynamic and spectroscopic studies.
Journal of molecular biology 1997;274(2):237-52.
1997: Pilch D S; Yu C; Makhey D; LaVoie E J; Srinivasan A R; Olson W K; Sauers R R; Breslauer K J; Geacintov N E; Liu L F
Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs.
Biochemistry 1997;36(41):12542-53.
1997: Xu Z; Pilch D S; Srinivasan A R; Olson W K; Geacintov N E; Breslauer K J
Modulation of nucleic acid structure by ligand binding: induction of a DNA.RNA.DNA hybrid triplex by DAPI intercalation.
Bioorganic & medicinal chemistry 1997;5(6):1137-47.
1997: Völker J; Osborne S E; Glick G D; Breslauer K J
Thermodynamic properties of a conformationally constrained intramolecular DNA triple helix.
Biochemistry 1997;36(4):756-67.
1996: Law S M; Eritja R; Goodman M F; Breslauer K J
Spectroscopic and calorimetric characterizations of DNA duplexes containing 2-aminopurine.
Biochemistry 1996;35(38):12329-37.
1996: Mielewczyk S S; Breslauer K J; Anachi R B; Brodsky B
Binding studies of a triple-helical peptide model of macrophage scavenger receptor to tetraplex nucleic acids.
Biochemistry 1996;35(35):11396-402.
1996: Pilch D S; Poklar N; Gelfand C A; Law S M; Breslauer K J; Baird E E; Dervan P B
Binding of a hairpin polyamide in the minor groove of DNA: sequence-specific enthalpic discrimination.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8306-11.
1996: Chalikian T V; Totrov M; Abagyan R; Breslauer K J
The hydration of globular proteins as derived from volume and compressibility measurements: cross correlating thermodynamic and structural data.
Journal of molecular biology 1996;260(4):588-603.
1996: Poklar N; Pilch D S; Lippard S J; Redding E A; Dunham S U; Breslauer K J
Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7606-11.
1996: Pilch D S; Xu Z; Sun Q; Lavoie E J; Liu L F; Geacintov N E; Breslauer K J
Characterizing the DNA binding modes of a topoisomerase I-poisoning terbenzimidazole: evidence for both intercalative and minor groove binding properties.
Drug design and discovery 1996;13(3-4):115-33.
1996: Gelfand C A; Plum G E; Grollman A P; Johnson F; Breslauer K J
The impact of a bistrand abasic lesion on DNA duplex properties.
Biopolymers 1996;38(4):439-45.
1996: Chalikian T V; Breslauer K J
Compressibility as a means to detect and characterize globular protein states.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1012-4.
1996: Chalikian T V; Gindikin V S; Breslauer K J
Spectroscopic and volumetric investigation of cytochrome c unfolding at alkaline pH: characterization of the base-induced unfolded state at 25 degrees C.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(1):164-70.
1995: Plum G E; Grollman A P; Johnson F; Breslauer K J
Influence of the oxidatively damaged adduct 8-oxodeoxyguanosine on the conformation, energetics, and thermodynamic stability of a DNA duplex.
Biochemistry 1995;34(49):16148-60.
1995: Pilch D S; Kirolos M A; Breslauer K J
Berenil binding to higher ordered nucleic acid structures: complexation with a DNA and RNA triple helix.
Biochemistry 1995;34(49):16107-24.
1995: Plum G E; Breslauer K J
Calorimetry of proteins and nucleic acids.
Current opinion in structural biology 1995;5(5):682-90.
1995: Pilch D S; Kirolos M A; Liu X; Plum G E; Breslauer K J
Berenil [1,3-bis(4'-amidinophenyl)triazene] binding to DNA duplexes and to a RNA duplex: evidence for both intercalative and minor groove binding properties.
Biochemistry 1995;34(31):9962-76.
1995: Chalikian T V; Gindikin V S; Breslauer K J
Volumetric characterizations of the native, molten globule and unfolded states of cytochrome c at acidic pH.
Journal of molecular biology 1995;250(2):291-306.
1995: Pilch D S; Plum G E; Breslauer K J
The thermodynamics of DNA structures that contain lesions or guanine tetrads.
Current opinion in structural biology 1995;5(3):334-42.
1995: Plum G E; Breslauer K J
Thermodynamics of an intramolecular DNA triple helix: a calorimetric and spectroscopic study of the pH and salt dependence of thermally induced structural transitions.
Journal of molecular biology 1995;248(3):679-95.
1995: Breslauer K J
Extracting thermodynamic data from equilibrium melting curves for oligonucleotide order-disorder transitions.
Methods in enzymology 1995;259():221-42.
1995: Plum G E; Pilch D S; Singleton S F; Breslauer K J
Nucleic acid hybridization: triplex stability and energetics.
Annual review of biophysics and biomolecular structure 1995;24():319-50.
1994: Pilch D S; Breslauer K J
Ligand-induced formation of nucleic acid triple helices.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9332-6.
1994: Chalikian T V; Sarvazyan A P; Breslauer K J
Hydration and partial compressibility of biological compounds.
Biophysical chemistry 1994;51(2-3):89-107; discussion 107-9.
1994: Plum G E; Breslauer K J
DNA lesions. A thermodynamic perspective.
Annals of the New York Academy of Sciences 1994;726():45-55; discussion 55-6.
1994: Chalikian T V; Plum G E; Sarvazyan A P; Breslauer K J
Influence of drug binding on DNA hydration: acoustic and densimetric characterizations of netropsin binding to the poly(dAdT).poly(dAdT) and poly(dA).poly(dT) duplexes and the poly(dT).poly(dA).poly(dT) triplex at 25 degrees C.
Biochemistry 1994;33(29):8629-40.
1994: Chalikian T V; Sarvazyan A P; Plum G E; Breslauer K J
Influence of base composition, base sequence, and duplex structure on DNA hydration: apparent molar volumes and apparent molar adiabatic compressibilities of synthetic and natural DNA duplexes at 25 degrees C.
Biochemistry 1994;33(9):2394-401.
1994: Breslauer K J
Extracting thermodynamic data from equilibrium melting curves for oligonucleotide order-disorder transitions.
Methods in molecular biology (Clifton, N.J.) 1994;26():347-72.
1993: Jin R; Chapman W H; Srinivasan A R; Olson W K; Breslow R; Breslauer K J
Comparative spectroscopic, calorimetric, and computational studies of nucleic acid complexes with 2',5"-versus 3',5"-phosphodiester linkages.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10568-72.
1993: Chan S S; Breslauer K J; Austin R H; Hogan M E
Thermodynamics and premelting conformational changes of phased (dA)5 tracts.
Biochemistry 1993;32(44):11776-84.
1993: Remeta D P; Mudd C P; Berger R L; Breslauer K J
Thermodynamic characterization of daunomycin-DNA interactions: comparison of complete binding profiles for a series of DNA host duplexes.
Biochemistry 1993;32(19):5064-73.
1993: Erie D A; Breslauer K J; Olson W K
A Monte Carlo method for generating structures of short single-stranded DNA sequences.
Biopolymers 1993;33(1):75-105.
1993: Erie D A; Suri A K; Breslauer K J; Jones R A; Olson W K
Theoretical predictions of DNA hairpin loop conformations: correlations with thermodynamic and spectroscopic data.
Biochemistry 1993;32(2):436-54.
1992: Plum G E; Grollman A P; Johnson F; Breslauer K J
Influence of an exocyclic guanine adduct on the thermal stability, conformation, and melting thermodynamics of a DNA duplex.
Biochemistry 1992;31(48):12096-102.
1992: Jin R; Gaffney B L; Wang C; Jones R A; Breslauer K J
Thermodynamics and structure of a DNA tetraplex: a spectroscopic and calorimetric study of the tetramolecular complexes of d(TG3T) and d(TG3T2G3T).
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8832-6.
1992: Park Y W; Breslauer K J
Drug binding to higher ordered DNA structures: netropsin complexation with a nucleic acid triple helix.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6653-7.
1992: Breslauer K J; Freire E; Straume M
Calorimetry: a tool for DNA and ligand-DNA studies.
Methods in enzymology 1992;211():533-67.
1991: Remeta D P; Mudd C P; Berger R L; Breslauer K J
Thermodynamic characterization of daunomycin-DNA interactions: microcalorimetric measurements of daunomycin-DNA binding enthalpies.
Biochemistry 1991;30(40):9799-809.
1991: Vesnaver G; Breslauer K J
The contribution of DNA single-stranded order to the thermodynamics of duplex formation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3569-73.
1991: Park Y W; Breslauer K J
A spectroscopic and calorimetric study of the melting behaviors of a "bent" and a "normal" DNA duplex: [d(GA4T4C)]2 versus [d(GT4A4C)]2.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1551-5.
1990: Plum G E; Park Y W; Singleton S F; Dervan P B; Breslauer K J
Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: a spectroscopic and calorimetric study.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9436-40.
1990: Chan S S; Breslauer K J; Hogan M E; Kessler D J; Austin R H; Ojemann J; Passner J M; Wiles N C
Physical studies of DNA premelting equilibria in duplexes with and without homo dA.dT tracts: correlations with DNA bending.
Biochemistry 1990;29(26):6161-71.
1989: Snyder J G; Hartman N G; D'Estantoit B L; Kennard O; Remeta D P; Breslauer K J
Binding of actinomycin D to DNA: evidence for a nonclassical high-affinity binding mode that does not require GpC sites.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):3968-72.
1989: Vesnaver G; Chang C N; Eisenberg M; Grollman A P; Breslauer K J
Influence of abasic and anucleosidic sites on the stability, conformation, and melting behavior of a DNA duplex: correlations of thermodynamic and structural data.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3614-8.
1989: Erie D A; Jones R A; Olson W K; Sinha N K; Breslauer K J
Melting behavior of a covalently closed, single-stranded, circular DNA.
Biochemistry 1989;28(1):268-73.
1988: Jin R; Breslauer K J
Characterization of the minor groove environment in a drug-DNA complex: bisbenzimide bound to the poly[d(AT)].poly[d(AT)]duplex.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):8939-42.
1988: Senior M M; Jones R A; Breslauer K J
Influence of loop residues on the relative stabilities of DNA hairpin structures.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(17):6242-6.
1988: Senior M; Jones R A; Breslauer K J
Influence of dangling thymidine residues on the stability and structure of two DNA duplexes.
Biochemistry 1988;27(10):3879-85.
1987: Breslauer K J; Remeta D P; Chou W Y; Ferrante R; Curry J; Zaunczkowski D; Snyder J G; Marky L A
Enthalpy-entropy compensations in drug-DNA binding studies.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8922-6.
1987: Erie D; Sinha N; Olson W; Jones R; Breslauer K
A dumbbell-shaped, double-hairpin structure of DNA: a thermodynamic investigation.
Biochemistry 1987;26(22):7150-9.
1987: Chou W Y; Marky L A; Zaunczkowski D; Breslauer K J
The thermodynamics of drug-DNA interactions: ethidium bromide and propidium iodide.
Journal of biomolecular structure & dynamics 1987;5(2):345-59.
1985: Marky L A; Curry J; Breslauer K J
Netropsin binding to polyd(AT) X polyd(AT) and to polydA X polydT: a comparative thermodynamic study.
Progress in clinical and biological research 1985;172B():155-73.
1983: Marky L A; Snyder J G; Remeta D P; Breslauer K J
Thermodynamics of drug-DNA interactions.
Journal of biomolecular structure & dynamics 1983;1(2):487-507.
1983: Marky L A; Snyder J G; Breslauer K J
Calorimetric and spectroscopic investigation of drug--DNA interactions: II. Dipyrandium binding to poly d(AT).
Nucleic acids research 1983;11(16):5701-15.

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