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Richard Wyatt

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Chemicals & Drugs

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HIV-1

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Neutralization Tests

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Jinghe Huang; Hiromi Imamichi; Peter D Kwong; Leo Laub; Nancy S Longo; Mark K Louder; John R Mascola; Stephen A Migueles; Gilad Ofek; Shailendra K Sharma; Tao Wang; Richard Wyatt; Yongping Yang; Baoshan Zhang; S Munir Alam; Robert T Bailer; Bimal Chakrabarti; Nicole A Doria-Rose; Barton F Haynes; Mark Connors
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
Takayuki Ota; Pascal Poignard; William R Schief; Devin Sok; Xueling Wu; Richard Wyatt; James M Binley; Dennis R Burton; Bimal K Chakrabarti; Anthony B Cooper; Katie J Doores; Colleen Doyle-Cooper; Emilia Falkowska; Lars Hangartner; Michael Huber; Joseph Jardine; Khoa Le; Jeffrey Lifson; John R Mascola; David Nemazee
Anti-HIV B Cell lines as candidate vaccine biosensors.
Dennis R Burton; Salvatore T Butera; Shane Crotty; Adam Godzik; Daniel E Kaufmann; M Juliana McElrath; Michel C Nussenzweig; Bali Pulendran; Chris N Scanlan; William R Schief; Guido Silvestri; Hendrik Streeck; Bruce D Walker; Laura M Walker; Andrew B Ward; Ian A Wilson; Rafi Ahmed; Dan H Barouch; Richard Wyatt
A Blueprint for HIV Vaccine Discovery.

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All Publications

2012: Jinghe Huang; Hiromi Imamichi; Peter D Kwong; Leo Laub; Nancy S Longo; Mark K Louder; John R Mascola; Stephen A Migueles; Gilad Ofek; Shailendra K Sharma; Tao Wang; Richard Wyatt; Yongping Yang; Baoshan Zhang; S Munir Alam; Robert T Bailer; Bimal Chakrabarti; Nicole A Doria-Rose; Barton F Haynes; Mark Connors
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
Nature 2012;491(7424):406-12.
2012: Takayuki Ota; Pascal Poignard; William R Schief; Devin Sok; Xueling Wu; Richard Wyatt; James M Binley; Dennis R Burton; Bimal K Chakrabarti; Anthony B Cooper; Katie J Doores; Colleen Doyle-Cooper; Emilia Falkowska; Lars Hangartner; Michael Huber; Joseph Jardine; Khoa Le; Jeffrey Lifson; John R Mascola; David Nemazee
Anti-HIV B Cell lines as candidate vaccine biosensors.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):4816-24.
2012: Dennis R Burton; Salvatore T Butera; Shane Crotty; Adam Godzik; Daniel E Kaufmann; M Juliana McElrath; Michel C Nussenzweig; Bali Pulendran; Chris N Scanlan; William R Schief; Guido Silvestri; Hendrik Streeck; Bruce D Walker; Laura M Walker; Andrew B Ward; Ian A Wilson; Rafi Ahmed; Dan H Barouch; Richard Wyatt
A Blueprint for HIV Vaccine Discovery.
Cell host & microbe 2012;12(4):396-407.
2012: Yuxing Li; Nancy S Longo; Mark K Louder; John R Mascola; Sijy O'Dell; Christian Poulsen; Mario Roederer; Stephen D Schmidt; Richard Wilson; Xueling Wu; Bimal K Chakrabarti; Mark Connors; Nicole Doria-Rose; Javier Guenaga; Carl-Magnus Hogerkorp; Richard Wyatt
HIV-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins.
Journal of virology 2012;86(20):11231-41.
2012: Christopher Sundling; Richard Wilson; Richard Wyatt; Yu Feng; Nick Huynh; Yuxing Li; John R Mascola; Sijy O'Dell; Christian Poulsen; Gunilla B Karlsson Hedestam
High-resolution definition of vaccine-elicited B cell responses against the HIV primary receptor binding site.
Science translational medicine 2012;4(142):142ra96.
2012: Pia Dosenovic; Emilie K Grasset; Michael P Cancro; Mikael C I Karlsson; John R Mascola; Sijy O'Dell; Nadège Pelletier; Jean L Scholz; Martina Soldemo; Richard Wyatt; Gunilla B Karlsson Hedestam
BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):6018-26.
2012: Xueling Wu; Richard Wyatt; Zhongjia Yang; Sijy O'Dell; George M Shaw; Charlene Wang; Mark Connors; Nicole Doria-Rose; James A Hoxie; Hiromi Imamichi; Brandon F Keele; Yuxing Li; John R Mascola
Selection pressure on HIV-1 envelope by broadly neutralizing antibodies to the conserved CD4-binding site.
Journal of virology 2012;86(10):5844-56.
2012: Emilia Falkowska; Yu Feng; Peter D Kwong; John R Mascola; Stephanie Moquin; Pascal Poignard; Alejandra Ramos; Michael S Seaman; Laura M Walker; Terri Wrin; Xueling Wu; Richard Wyatt; Tongqing Zhou; Dennis R Burton
PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.
Journal of virology 2012;86(8):4394-403.
2012: Yu Feng; Mattias N Forsell; Gunilla B Karlsson Hedestam; John R Mascola; Krisha McKee; Sijy O'Dell; Adhuna Phogat; Stephen D Schmidt; Karen Tran; Richard Wyatt
Biochemically defined HIV-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the CD4-binding site.
The Journal of biological chemistry 2012;287(8):5673-86.
2012: Javier Guenaga; Richard Wyatt
Structure-guided alterations of the gp41-directed HIV-1 broadly neutralizing antibody 2F5 reveal new properties regarding its neutralizing function.
PLoS pathogens 2012;8(7):e1002806.
2011: Yuxing Li; Mark K Louder; Dennis R Burton; Yu Feng; Barney S Graham; Javier Guenaga; Barton F Haynes; Julie E Ledgerwood; Krisha McKee; Sijy O'Dell; Stephen D Schmidt; Laura M Walker; Xueling Wu; Richard Wyatt; John R Mascola
Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01.
Journal of virology 2011;85(17):8954-67.
2011: B K Chakrabarti; A Ghobbeh; J F Guenaga; Pascal Poignard; L M Walker; Dennis R Burton; Richard Wyatt
Direct antibody access to the HIV-1 membrane-proximal external region positively correlates with neutralization sensitivity.
Journal of virology 2011;85(16):8217-26.
2011: Bimal K Chakrabarti; Javier Guenaga; John Mascola; Krisha McKee; Sijy O'Dell; Marie Pancera; Sanjay Phogat; James Robinson; Richard Wyatt
HIV type 1 Env precursor cleavage state affects recognition by both neutralizing and nonneutralizing gp41 antibodies.
AIDS research and human retroviruses 2011;27(8):877-87.
2011: Javier Guenaga; Pia Dosenovic; Gilad Ofek; David Baker; William R Schief; Peter D Kwong; Gunilla B Karlsson Hedestam; Richard Wyatt
Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant.
PloS one 2011;6(1):e16074.
2010: Gilad Ofek; F Javier Guenaga; William R Schief; Jeff Skinner; David Baker; Richard Wyatt; Peter D Kwong
Elicitation of structure-specific antibodies by epitope scaffolds.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):17880-7.
2010: Christopher Sundling; Sijy O'Dell; Iyadh Douagi; Mattias N Forsell; Andreas Mörner; Karin Loré; John R Mascola; Richard Wyatt; Gunilla B Karlsson Hedestam
Immunization with wild-type or CD4-binding-defective HIV-1 Env trimers reduces viremia equivalently following heterologous challenge with simian-human immunodeficiency virus.
Journal of virology 2010;84(18):9086-95.
2010: Christopher Sundling; Mattias N E Forsell; Sijy O'Dell; Yu Feng; Bimal Chakrabarti; SRINIVAS RAO; Karin Loré; John R Mascola; Richard Wyatt; Iyadh Douagi; Gunilla B Karlsson Hedestam
Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates.
The Journal of experimental medicine 2010;207(9):2003-17.
2010: Xueling Wu; Zhi-Yong Yang; Yuxing Li; Carl-Magnus Hogerkorp; William R Schief; Michael S Seaman; Tongqing Zhou; Stephen D Schmidt; Lan Wu; Ling Xu; Nancy S Longo; Krisha McKee; Sijy O'Dell; Mark K Louder; Diane L Wycuff; Yu Feng; Martha Nason; Nicole Doria-Rose; Mark Connors; Peter D Kwong; Mario Roederer; Richard Wyatt; Gary Nabel; John R Mascola
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1.
Science (New York, N.Y.) 2010;329(5993):856-61.
2010: Iyadh Douagi; Mattias N E Forsell; Christopher Sundling; Sijy O'Dell; Yu Feng; Pia Dosenovic; Yuxing Li; Robert Seder; Karin Loré; John R Mascola; Richard Wyatt; Gunilla B Karlsson Hedestam
Influence of novel CD4 binding-defective HIV-1 envelope glycoprotein immunogens on neutralizing antibody and T-cell responses in nonhuman primates.
Journal of virology 2010;84(4):1683-95.
2010: Nicole A Doria-Rose; Rachel M Klein; Marcus G Daniels; Sijy O'Dell; Martha Nason; Alan Lapedes; Tanmoy Bhattacharya; Stephen A Migueles; Richard Wyatt; Bette T Korber; John R Mascola; Mark Connors
Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables.
Journal of virology 2010;84(3):1631-6.
2010: Marie Pancera; Shahzad Majeed; Yih-En Andrew Ban; Lei Chen; Chih-chin Huang; Leopold Kong; Young Do Kwon; Jonathan Stuckey; Tongqing Zhou; James E Robinson; William R Schief; Joseph Sodroski; Richard Wyatt; Peter D Kwong
Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(3):1166-71.
2009: Lei Chen; Young Do Kwon; Tongqing Zhou; Xueling Wu; Sijy O'Dell; Lisa Cavacini; Ann J Hessell; Marie Pancera; Min Tang; Ling Xu; Zhi-Yong Yang; Mei-Yun Zhang; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Gary Nabel; Marshall R Posner; Joseph Sodroski; Richard Wyatt; John R Mascola; Peter D Kwong
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Science (New York, N.Y.) 2009;326(5956):1123-7.
2009: Xueling Wu; Tongqing Zhou; Sijy O'Dell; Richard Wyatt; Peter D Kwong; John R Mascola
Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment.
Journal of virology 2009;83(21):10892-907.
2009: Mattias N E Forsell; William R Schief; Richard Wyatt
Immunogenicity of HIV-1 envelope glycoprotein oligomers.
Current opinion in HIV and AIDS 2009;4(5):380-7.
2009: Pia Dosenovic; Bimal Chakrabarti; Martina Soldemo; Iyadh Douagi; Mattias N E Forsell; Yuxing Li; Adhuna Phogat; Staffan Paulie; James Hoxie; Richard Wyatt; Gunilla B Karlsson Hedestam
Selective expansion of HIV-1 envelope glycoprotein-specific B cell subsets recognizing distinct structural elements following immunization.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):3373-82.
2009: Barna Dey; Krisha Svehla; Ling Xu; Dianne Wycuff; Tongqing Zhou; Gerald Voss; Adhuna Phogat; Bimal K Chakrabarti; Yuxing Li; George Shaw; Peter D Kwong; Gary Nabel; John R Mascola; Richard Wyatt
Structure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding site.
PLoS pathogens 2009;5(5):e1000445.
2009: Johannes F Scheid; Hugo Mouquet; Niklas Feldhahn; Bruce D Walker; Florencia Pereyra; Emily Cutrell; Michael S Seaman; John R Mascola; Richard Wyatt; Hedda Wardemann; Michel C Nussenzweig
A method for identification of HIV gp140 binding memory B cells in human blood.
Journal of immunological methods 2009;343(2):65-7.
2009: Johannes F Scheid; Hugo Mouquet; Niklas Feldhahn; Michael S Seaman; Klara Velinzon; John Pietzsch; Rene G Ott; Robert M Anthony; Henry Zebroski; Arlene Hurley; Adhuna Phogat; Bimal Chakrabarti; Yuxing Li; Mark Connors; Florencia Pereyra; Bruce D Walker; Hedda Wardemann; David Ho; Richard Wyatt; John R Mascola; Jeffrey V Ravetch; Michel C Nussenzweig
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals.
Nature 2009;458(7238):636-40.
2009: Andreas Mörner; Iyadh Douagi; Mattias Forsell; Christopher Sundling; Pia Dosenovic; Sijy O'Dell; Barna Dey; Peter D Kwong; Gerald Voss; Rigmor Thorstensson; John R Mascola; Richard Wyatt; Gunilla B Karlsson Hedestam
Human immunodeficiency virus type 1 env trimer immunization of macaques and impact of priming with viral vector or stabilized core protein.
Journal of virology 2009;83(2):540-51.
2009: Yuxing Li; Krisha Svehla; Mark K Louder; Diane Wycuff; Sanjay Phogat; Min Tang; Stephen A Migueles; Xueling Wu; Adhuna Phogat; George M Shaw; Mark Connors; James A Hoxie; John R Mascola; Richard Wyatt
Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals.
Journal of virology 2009;83(2):1045-59.
2009: Nicole A Doria-Rose; Rachel M Klein; Maura M Manion; Sijy O'Dell; Adhuna Phogat; Bimal K Chakrabarti; Claire W Hallahan; Stephen A Migueles; Jens Wrammert; Rafi Ahmed; Martha Nason; Richard Wyatt; John R Mascola; Mark Connors
Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies.
Journal of virology 2009;83(1):188-99.
2008: Christopher Sundling; Karin Schön; Andreas Mörner; Mattias Forsell; Richard Wyatt; Rigmor Thorstensson; Gunilla B Karlsson Hedestam; Nils Y Lycke
CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization.
The Journal of general virology 2008;89(Pt 12):2954-64.
2008: Son N Lam; Priyamvada Acharya; Richard Wyatt; Peter D Kwong; Carole A Bewley
Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry.
Bioorganic & medicinal chemistry 2008;16(23):10113-20.
2008: Navid Madani; Arne Schön; Amy M Princiotto; Judith M Lalonde; Joel R Courter; Takahiro Soeta; Danny Ng; Liping Wang; Evan T Brower; Shi-Hua Xiang; Young Do Kwon; Chih-Chin Huang; Richard Wyatt; Peter D Kwong; Ernesto Freire; Amos B Smith; Joseph Sodroski
Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.
Structure (London, England : 1993) 2008;16(11):1689-701.
2008: Sanjay Phogat; Krisha Svehla; Min Tang; A Spadaccini; J Muller; John R Mascola; I Berkower; Richard Wyatt
Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis B surface antigen particles.
Virology 2008;373(1):72-84.
2008: Suganya Selvarajah; Bridget A Puffer; Fang-Hua Lee; Ping Zhu; Yuxing Li; Richard Wyatt; Kenneth H Roux; Robert W Doms; Dennis R Burton
Focused dampening of antibody response to the immunodominant variable loops by engineered soluble gp140.
AIDS research and human retroviruses 2008;24(2):301-14.
2008: Gunilla B Karlsson Hedestam; Ron A M Fouchier; Sanjay Phogat; Dennis R Burton; Joseph Sodroski; Richard Wyatt
The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.
Nature reviews. Microbiology 2008;6(2):143-55.
2008: Mattias Forsell; Barna Dey; Andreas Mörner; Krisha Svehla; Sijy O'dell; Carl-Magnus Högerkorp; Gerald Voss; Rigmor Thorstensson; George M Shaw; John R Mascola; Gunilla B Karlsson Hedestam; Richard Wyatt
B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4.
PLoS pathogens 2008;4(10):e1000171.
2007: Hui Xie; Danny Ng; Sergey N Savinov; Barna Dey; Peter D Kwong; Richard Wyatt; Amos B Smith; Wayne A Hendrickson
Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus.
Journal of medicinal chemistry 2007;50(20):4898-908.
2007: Chih-Chin Huang; Son N Lam; Priyamvada Acharya; Min Tang; Shi-Hua Xiang; Syed Shahzad-Ul Hussan; Robyn L Stanfield; James Robinson; Joseph Sodroski; Ian A Wilson; Richard Wyatt; Carole A Bewley; Peter D Kwong
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.
Science (New York, N.Y.) 2007;317(5846):1930-4.
2007: Yuxing Li; Stephen A Migueles; Brent Welcher; Krisha Svehla; Adhuna Phogat; Mark K Louder; Xueling Wu; George M Shaw; Mark Connors; Richard Wyatt; John R Mascola
Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
Nature medicine 2007;13(9):1032-4.
2007: Sanjay Phogat; Richard Wyatt; G B Karlsson Hedestam
Inhibition of HIV-1 entry by antibodies: potential viral and cellular targets.
Journal of internal medicine 2007;262(1):26-43.
2007: Barna Dey; Marie Pancera; Krisha Svehla; Yuuei Shu; Shi-Hua Xiang; Jeffrey Vainshtein; Yuxing Li; Joseph Sodroski; Peter D Kwong; John R Mascola; Richard Wyatt
Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the CD4-bound state: antigenicity, biophysics, and immunogenicity.
Journal of virology 2007;81(11):5579-93.
2007: Tongqing Zhou; Ling Xu; Barna Dey; Ann J Hessell; Donald Van Ryk; Shi-Hua Xiang; Xinzhen Yang; Mei-Yun Zhang; Michael B Zwick; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Joseph Sodroski; Richard Wyatt; Gary Nabel; Peter D Kwong
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Nature 2007;445(7129):732-7.
2007: Sanjay Phogat; Richard Wyatt
Rational modifications of HIV-1 envelope glycoproteins for immunogen design.
Current pharmaceutical design 2007;13(2):213-27.
2006: Iva Navratilova; Marie Pancera; Richard Wyatt; David G Myszka
A biosensor-based approach toward purification and crystallization of G protein-coupled receptors.
Analytical biochemistry 2006;353(2):278-83.
2006: Yan Li; Krisha Svehla; Nathalie Mathy; G Voss; John R Mascola; Richard Wyatt
Characterization of antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants.
Journal of virology 2006;80(3):1414-26.
2005: Chih-chin Huang; Min Tang; Mei-Yun Zhang; Shahzad Majeed; Elizabeth Montabana; Robyn L Stanfield; Dimiter S Dimitrov; Bette Korber; Joseph Sodroski; Ian A Wilson; Richard Wyatt; Peter D Kwong
Structure of a V3-containing HIV-1 gp120 core.
Science (New York, N.Y.) 2005;310(5750):1025-8.
2005: Markus Koch; James Frazier; Joseph Sodroski; Richard Wyatt
Characterization of antibody responses to purified HIV-1 gp120 glycoproteins fused with the molecular adjuvant C3d.
Virology 2005;340(2):277-84.
2005: Mattias Forsell; Yuxing Li; Maria Sundbäck; Krisha Svehla; Peter Liljeström; John R Mascola; Richard Wyatt; Gunilla B Karlsson Hedestam
Biochemical and immunogenic characterization of soluble human immunodeficiency virus type 1 envelope glycoprotein trimers expressed by semliki forest virus.
Journal of virology 2005;79(17):10902-14.
2005: Marie Pancera; Jacob Lebowitz; Arne Schön; Ping Zhu; Ernesto Freire; Peter D Kwong; Kenneth H Roux; Joseph Sodroski; Richard Wyatt
Soluble mimetics of human immunodeficiency virus type 1 viral spikes produced by replacement of the native trimerization domain with a heterologous trimerization motif: characterization and ligand binding analysis.
Journal of virology 2005;79(15):9954-69.
2005: Chih-chin Huang; François Stricher; Loic MARTIN; Julie M Decker; Shahzad Majeed; Philippe Barthe; Wayne A Hendrickson; James Robinson; Christian Roumestand; Joseph Sodroski; Richard Wyatt; George M Shaw; Claudio Vita; Peter D Kwong
Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.
Structure (London, England : 1993) 2005;13(5):755-68.
2005: Marie Pancera; Richard Wyatt
Selective recognition of oligomeric HIV-1 primary isolate envelope glycoproteins by potently neutralizing ligands requires efficient precursor cleavage.
Virology 2005;332(1):145-56.
2005: Christoph Grundner; Yuxing Li; Mark K Louder; John R Mascola; Xinzhen Yang; Joseph Sodroski; Richard Wyatt
Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins.
Virology 2005;331(1):33-46.
2004: Christoph Grundner; Marie Pancera; Joung-Mo Kang; Markus Koch; Joseph Sodroski; Richard Wyatt
Factors limiting the immunogenicity of HIV-1 gp120 envelope glycoproteins.
Virology 2004;330(1):233-48.
2004: Gilad Ofek; Min Tang; Anna Sambor; Hermann Katinger; John R Mascola; Richard Wyatt; Peter D Kwong
Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope.
Journal of virology 2004;78(19):10724-37.
2004: Chih-chin Huang; Miro Venturi; Shahzad Majeed; Michael J Moore; Sanjay Phogat; Mei-Yun Zhang; Dimiter S Dimitrov; Wayne A Hendrickson; James Robinson; Joseph Sodroski; Richard Wyatt; Hyeryun Choe; Michael Farzan; Peter D Kwong
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2706-11.
2004: Dennis R Burton; Ronald C Desrosiers; Robert W Doms; Wayne C Koff; Peter D Kwong; John P Moore; Gary Nabel; Joseph Sodroski; Ian A Wilson; Richard Wyatt
HIV vaccine design and the neutralizing antibody problem.
Nature immunology 2004;5(3):233-6.
2003: Aran F Labrijn; Pascal Poignard; Aarti Raja; Michael B Zwick; Karla Delgado; Michael Franti; James M Binley; Veronique Vivona; Christoph Grundner; Chih-Chin Huang; Miro Venturi; Christos J Petropoulos; Terri Wrin; Dimiter S Dimitrov; James Robinson; Peter D Kwong; Richard Wyatt; Joseph Sodroski; Dennis R Burton
Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1.
Journal of virology 2003;77(19):10557-65.
2003: Markus Koch; Marie Pancera; Peter D Kwong; Peter Kolchinsky; Christoph Grundner; Liping Wang; Wayne A Hendrickson; Joseph Sodroski; Richard Wyatt
Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition.
Virology 2003;313(2):387-400.
2002: Peter D Kwong; Michael Doyle; David J Casper; Claudia Cicala; Stephanie A Leavitt; Shahzad Majeed; Tavis D Steenbeke; Miro Venturi; Irwin Chaiken; Michael Fung; Hermann Katinger; Paul W I H Parren; James Robinson; Donald Van Ryk; Liping Wang; Dennis R Burton; Ernesto Freire; Richard Wyatt; Joseph Sodroski; Wayne A Hendrickson; James Arthos
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.
Nature 2002;420(6916):678-82.
2002: Shi-Hua Xiang; Peter D Kwong; Rishi Gupta; Carlo D Rizzuto; David J Casper; Richard Wyatt; Liping Wang; Wayne A Hendrickson; Michael Doyle; Joseph Sodroski
Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein.
Journal of virology 2002;76(19):9888-99.
2002: Xinzhen Yang; Juliette Lee; Erin M Mahony; Peter D Kwong; Richard Wyatt; Joseph Sodroski
Highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of T4 bacteriophage fibritin.
Journal of virology 2002;76(9):4634-42.
2002: Christoph Grundner; Tajib Mirzabekov; Joseph Sodroski; Richard Wyatt
Solid-phase proteoliposomes containing human immunodeficiency virus envelope glycoproteins.
Journal of virology 2002;76(7):3511-21.
2001: Wei Zhang; Alexis P Godillot; Richard Wyatt; Joseph Sodroski; Irwin Chaiken
Antibody 17b binding at the coreceptor site weakens the kinetics of the interaction of envelope glycoprotein gp120 with CD4.
Biochemistry 2001;40(6):1662-70.
2001: X Yang; Richard Wyatt; Joseph Sodroski
Improved elicitation of neutralizing antibodies against primary human immunodeficiency viruses by soluble stabilized envelope glycoprotein trimers.
Journal of virology 2001;75(3):1165-71.
2000: Peter D Kwong; Richard Wyatt; Shahzad Majeed; James Robinson; Raymond W Sweet; Joseph Sodroski; Wayne A Hendrickson
Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.
Structure (London, England : 1993) 2000;8(12):1329-39.
2000: David G Myszka; Raymond W Sweet; Preston Hensley; Michael Brigham-Burke; Peter D Kwong; Wayne A Hendrickson; Richard Wyatt; Joseph Sodroski; Michael Doyle
Energetics of the HIV gp120-CD4 binding reaction.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9026-31.
2000: Xinzhen Yang; Michael Farzan; Richard Wyatt; Joseph Sodroski
Characterization of stable, soluble trimers containing complete ectodomains of human immunodeficiency virus type 1 envelope glycoproteins.
Journal of virology 2000;74(12):5716-25.
2000: Xinzhen Yang; L Florin; Michael Farzan; Peter Kolchinsky; Peter D Kwong; Joseph Sodroski; Richard Wyatt
Modifications that stabilize human immunodeficiency virus envelope glycoprotein trimers in solution.
Journal of virology 2000;74(10):4746-54.
2000: Peter D Kwong; Richard Wyatt; Quentin J Sattentau; Joseph Sodroski; Wayne A Hendrickson
Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus.
Journal of virology 2000;74(4):1961-72.
2000: Maxime Moulard; Hugues Lortat-Jacob; I Mondor; G Roca; Richard Wyatt; Joseph Sodroski; L Zhao; W Olson; Peter D Kwong; Quentin J Sattentau
Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120.
Journal of virology 2000;74(4):1948-60.
1999: Tajib Mirzabekov; N Bannert; Michael Farzan; Wolfgang Hofmann; Peter Kolchinsky; Lizi Wu; Richard Wyatt; Joseph Sodroski
Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor.
The Journal of biological chemistry 1999;274(40):28745-50.
1999: Wei Zhang; Gabriela Canziani; Carmela G Plugariu; Richard Wyatt; Joseph Sodroski; R Sweet; Peter D Kwong; Wayne A Hendrickson; Irwin Chaiken
Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic.
Biochemistry 1999;38(29):9405-16.
1999: Michael Farzan; Tajib Mirzabekov; Peter Kolchinsky; Richard Wyatt; Mark Cayabyab; Norma P Gerard; Craig Gerard; Joseph Sodroski; Hyeryun Choe
Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.
Cell 1999;96(5):667-76.
1999: Peter D Kwong; Richard Wyatt; E Desjardins; James Robinson; J S Culp; B D Hellmig; Raymond W Sweet; Joseph Sodroski; Wayne A Hendrickson
Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1).
The Journal of biological chemistry 1999;274(7):4115-23.
1998: GB Karlsson; M Halloran; D Schenten; Juliette Lee; Paul Racz; Klara Tenner-Racz; Judith Manola; Rebecca Gelman; Bijan Etemad-Moghadam; E Desjardins; Richard Wyatt; Norma P Gerard; L Marcon; David H Margolin; John W Fanton; Michael K Axthelm; Norman L Letvin; Joseph Sodroski
The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques.
The Journal of experimental medicine 1998;188(6):1159-71.
1998: I Mondor; Maxime Moulard; S Ugolini; Per Johan Klasse; James A Hoxie; Ali Amara; Thierry Delaunay; Richard Wyatt; Joseph Sodroski; Quentin J Sattentau
Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies.
Virology 1998;248(2):394-405.
1998: Michael Farzan; Hyeryun Choe; E Desjardins; YanPing Sun; J Kuhn; J Cao; D Archambault; Peter Kolchinsky; Markus Koch; Richard Wyatt; Joseph Sodroski
Stabilization of human immunodeficiency virus type 1 envelope glycoprotein trimers by disulfide bonds introduced into the gp41 glycoprotein ectodomain.
Journal of virology 1998;72(9):7620-5.
1998: Carlo D Rizzuto; Richard Wyatt; N Hernández-Ramos; Ying Sun; Peter D Kwong; Wayne A Hendrickson; Joseph Sodroski
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.
Science (New York, N.Y.) 1998;280(5371):1949-53.
1998: Richard Wyatt; Joseph Sodroski
The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens.
Science (New York, N.Y.) 1998;280(5371):1884-8.
1998: Richard Wyatt; Peter D Kwong; E Desjardins; Raymond W Sweet; James Robinson; Wayne A Hendrickson; Joseph Sodroski
The antigenic structure of the HIV gp120 envelope glycoprotein.
Nature 1998;393(6686):705-11.
1998: Peter D Kwong; Richard Wyatt; James Robinson; Raymond W Sweet; Joseph Sodroski; Wayne A Hendrickson
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.
Nature 1998;393(6686):648-59.
1998: James M Binley; Richard Wyatt; E Desjardins; Peter D Kwong; Wayne A Hendrickson; John P Moore; Joseph Sodroski
Analysis of the interaction of antibodies with a conserved enzymatically deglycosylated core of the HIV type 1 envelope glycoprotein 120.
AIDS research and human retroviruses 1998;14(3):191-8.
1998: Michael Farzan; Hyeryun Choe; L Vaca; K Martin; YanPing Sun; E Desjardins; N Ruffing; Lijun Wu; Richard Wyatt; Norma P Gerard; Craig Gerard; Joseph Sodroski
A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5.
Journal of virology 1998;72(2):1160-4.
1998: Shan Lu; Richard Wyatt; JF Richmond; Farah Mustafa; Shixia Wang; J Weng; David C Montefiori; Joseph Sodroski; Harriet L Robinson
Immunogenicity of DNA vaccines expressing human immunodeficiency virus type 1 envelope glycoprotein with and without deletions in the V1/2 and V3 regions.
AIDS research and human retroviruses 1998;14(2):151-5.
1997: J Cao; N Sullivan; E Desjardin; Cristina Parolin; J Robinson; Richard Wyatt; Joseph Sodroski
Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein.
Journal of virology 1997;71(12):9808-12.
1997: Richard Wyatt; E Desjardin; U Olshevsky; C Nixon; James M Binley; V Olshevsky; Joseph Sodroski
Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein.
Journal of virology 1997;71(12):9722-31.
1997: KA Martin; Richard Wyatt; Michael Farzan; Hyeryun Choe; L Marcon; E Desjardins; James Robinson; Joseph Sodroski; Craig Gerard; Norma P Gerard
CD4-independent binding of SIV gp120 to rhesus CCR5.
Science (New York, N.Y.) 1997;278(5342):1470-3.
1996: Lijun Wu; Norma P Gerard; Richard Wyatt; Hyeryun Choe; Cristina Parolin; N Ruffing; Alessandra Borsetti; Angelo A Cardoso; E Desjardin; W Newman; Craig Gerard; Joseph Sodroski
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.
Nature 1996;384(6605):179-83.
1996: Joseph Sodroski; Richard Wyatt; U Olshevsky; V Olshevsky; J Moore
Conformation of the HIV-1 gp 120 envelope glycoprotein.
Antibiotics and chemotherapy 1996;48():184-7.
1995: Richard Wyatt; J Moore; MA Accola; E Desjardin; J Robinson; Joseph Sodroski
Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding.
Journal of virology 1995;69(9):5723-33.
1994: J P Moore; Quentin J Sattentau; Richard Wyatt; Joseph Sodroski
Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies.
Journal of virology 1994;68(1):469-84.
1993: Richard Wyatt; N Sullivan; M Thali; H Repke; D Ho; J Robinson; Marshall R Posner; Joseph Sodroski
Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions.
Journal of virology 1993;67(8):4557-65.
1992: Richard Wyatt; M Thali; S Tilley; A Pinter; Marshall R Posner; D Ho; J Robinson; Joseph Sodroski
Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region.
Journal of virology 1992;66(12):6997-7004.