FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

David Wyllie

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Procedures

Patch-Clamp Techniques

Concepts & Ideas

Occupations

Electrophysiology

Physiology

Co-author Network

Publications

TOP 3
Lasani S WIjetunge; David J A Wyllie; Sumantra Chattarji; Peter C Kind
Fragile X syndrome: from targets to treatments.
S Edman; Giles E Hardingham; M R Livesey; L J Macdonald; S McKay; M Samadi; David J A Wyllie
TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
Rickie Patani; Clare A Puddifoot; Siddharthan Chandran; Giles E Hardingham; John Hardy; Patrick A Lewis; Colin Smith; Daniah Trabzuni; Robert Walker; Michael Weale; David J A Wyllie; Mina Ryten
Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of David Wyllie (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Lasani S WIjetunge; David J A Wyllie; Sumantra Chattarji; Peter C Kind
Fragile X syndrome: from targets to treatments.
Neuropharmacology 2013;68():83-96.
2012: S Edman; Giles E Hardingham; M R Livesey; L J Macdonald; S McKay; M Samadi; David J A Wyllie
TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
Neuropharmacology 2012;63(3):441-9.
2012: Rickie Patani; Clare A Puddifoot; Siddharthan Chandran; Giles E Hardingham; John Hardy; Patrick A Lewis; Colin Smith; Daniah Trabzuni; Robert Walker; Michael Weale; David J A Wyllie; Mina Ryten
Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis.
Journal of neurochemistry 2012;122(4):738-51.
2012: S McKay; P A Butters; N H Griffiths; G E Hardingham; E B Thubron; David J A Wyllie
Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.
British journal of pharmacology 2012;166(3):924-37.
2012: Clare Puddifoot; Francesc X Soriano; antonio vidal-puig; David J A Wyllie; Alberto Camacho; Marc-Andre Martel; Giles E Hardingham
PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(20):6995-7000.
2012: Marc-André Martel; Aoife McMahon; Tomas John Ryan; David J A Wyllie; Bashayer Al-Mubarak; Karen F S Bell; Jill H Fowler; Seth G N Grant; Karen Horsburgh; Peter Cornell Kind; Noboru H Komiyama; Giles E Hardingham
The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.
Neuron 2012;74(3):543-56.
2012: Bilada Bilican; Monica Carrasco; Sami J Barmada; George Q Daley; Steven Finkbeiner; Judy Fletcher; Brad A Friedman; Giles E Hardingham; Tom Maniatis; Agnes Lumi Nishimura; In-Hyun Park; Hemali P Phatnani; Clare A Puddifoot; Andrea Serio; Christopher E Shaw; David Story; Gareth J Sullivan; Ian Wilmut; David J A Wyllie; Siddharthan Chandran
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(15):5803-8.
2012: David J A Wyllie; Stephen F Traynelis
NMDA receptor permeation: a light in the tunnel.
Nature neuroscience 2012;15(3):343-4.
2012: A C McMahon; T S O'Leary; Sofia Papadia; P N Stoney; David J A Wyllie; Mark W Barnett; Jyoti S Choudhary; Mark Collins; S G N Grant; Giles E Hardingham; Noboru H Komiyama; Peter Cornell Kind
SynGAP isoforms exert opposing effects on synaptic strength.
Nature communications 2012;3():900.
2011: Timothy O'Leary; David J A Wyllie
Neuronal homeostasis: time for a change?
The Journal of physiology 2011;589(Pt 20):4811-26.
2011: H J Otton; A Lawson McLean; M A Pannozzo; Ceri H Davies; David J A Wyllie
Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs.
Neuropharmacology 2011;60(2-3):388-96.
2011: R Patani; A J Hollins; T M Wishart; C A Puddifoot; S Alvarez; A R de Lera; David J A Wyllie; D A S Compston; Roger A Pedersen; T H Gillingwater; Giles E Hardingham; Nicholas D Allen; Siddharthan Chandran
Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state.
Nature communications 2011;2():214.
2010: Emma L Clayton; Nancy Sue; Karen J Smillie; Timothy O'Leary; Nicolai Bache; Giselle Cheung; Adam R Cole; David J A Wyllie; Calum Sutherland; Phillip J Robinson; Michael A Cousin
Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.
Nature neuroscience 2010;13(7):845-51.
2010: Emma M Perkins; Yvonne L Clarkson; Nancy Sabatier; David M Longhurst; Christopher P Millward; Jennifer Jack; Junko Toraiwa; Mitsunori Watanabe; Jeffrey rothstein; Alastair R Lyndon; David J A Wyllie; Mayank B Dutia; Mandy Jackson
Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(14):4857-67.
2010: Frédéric Léveillé; Sofia Papadia; Michael Fricker; Karen F S Bell; Francesc X Soriano; Marc-André Martel; Clare Puddifoot; Marlen Habel; David J A Wyllie; Chrysanthy Ikonomidou; Aviva M Tolkovsky; Giles E Hardingham
Suppression of the intrinsic apoptosis pathway by synaptic activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(7):2623-35.
2010: Timothy O'Leary; Mark C W van Rossum; David J A Wyllie
Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization.
The Journal of physiology 2010;588(Pt 1):157-70.
2009: Hannah J Otton; Ariane Janssen; David J A Wyllie
Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies.
Biochemical Society transactions 2009;37(Pt 6):1423-5.
2009: Timothy O'Leary; David J A Wyllie
Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits.
Biochemical Society transactions 2009;37(Pt 6):1347-54.
2009: Hannah J Otton; Ariane Janssen; Timothy O'Leary; Philip E Chen; David J A Wyllie
Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit.
European journal of pharmacology 2009;614(1-3):14-21.
2009: C A Puddifoot; Philip E Chen; R Schoepfer; David J A Wyllie
Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes.
British journal of pharmacology 2009;156(3):509-18.
2009: M-A Martel; David J A Wyllie; Giles E Hardingham
In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death.
Neuroscience 2009;158(1):334-43.
2009: Rickie Patani; Alastair Compston; Clare A Puddifoot; David J A Wyllie; Giles E Hardingham; Nicholas D Allen; Siddharthan Chandran
Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.
PloS one 2009;4(10):e7327.
2009: Marc-Andre Martel; Francesc X Soriano; Paul Baxter; Colin Rickman; Rory Duncan; David J A Wyllie; Giles E Hardingham
Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression.
Channels (Austin, Tex.) 2009;3(1):12-5.
2008: Francesc X Soriano; Marc-Andre Martel; Sofia Papadia; Anne Vaslin; Paul Baxter; Colin Rickman; Joan Forder; Michael Tymianski; Rory Duncan; Michelle Aarts; Peter Clarke; David J A Wyllie; Giles E Hardingham
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(42):10696-710.
2008: Sofia Papadia; Francesc X Soriano; Frédéric Léveillé; Marc-Andre Martel; Kelly A Dakin; Henrik H Hansen; Angela Kaindl; Marco Sifringer; Jill Fowler; Vanya Stefovska; Grahame McKenzie; Marie Craigon; Roderick Corriveau; Peter Ghazal; Karen Horsburgh; Bruce A Yankner; David J A Wyllie; Chrysanthy Ikonomidou; Giles E Hardingham
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.
Nature neuroscience 2008;11(4):476-87.
2008: David J A Wyllie
2B or 2B and 2D? - that is the question.
The Journal of physiology 2008;586(3):693.
2008: David C Wrighton; Edward J Baker; Philip E Chen; David J A Wyllie
Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes.
The Journal of physiology 2008;586(1):211-25.
2008: Philip E Chen; Matthew T Geballe; Elyse Katz; Kevin Erreger; Matthew R Livesey; Kate K O'Toole; Phuong Le; C Justin Lee; James P Snyder; Stephen F Traynelis; David J A Wyllie
Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes.
The Journal of physiology 2008;586(1):227-45.
2007: Kevin Erreger; Matthew T Geballe; Anders Skov Kristensen; Philip E Chen; Kasper B Hansen; C Justin Lee; Hongjie Yuan; Phuong Le; Polina Lyuboslavsky; Nicola Micale; Lars Jørgensen; Rasmus P Clausen; David J A Wyllie; James P Snyder; Stephen F Traynelis
Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors.
Molecular pharmacology 2007;72(4):907-20.
2007: Catherine Vickers; David J A Wyllie
Late-phase, protein synthesis-dependent long-term potentiation in hippocampal CA1 pyramidal neurones with destabilized microtubule networks.
British journal of pharmacology 2007;151(7):1071-7.
2007: David J A Wyllie; Philip E Chen
Taking the time to study competitive antagonism.
British journal of pharmacology 2007;150(5):541-51.
2006: Pamela A Frizelle; Philip E Chen; David J A Wyllie
Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies of synaptic transmission.
Molecular pharmacology 2006;70(3):1022-32.
2006: David J A Wyllie; Alexander R Johnston; Diane Lipscombe; Philip E Chen
Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit.
The Journal of physiology 2006;574(Pt 2):477-89.
2006: Andrew W Baxter; David J A Wyllie
Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L-type calcium channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(20):5456-69.
2006: Philip E Chen; David J A Wyllie
Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors.
British journal of pharmacology 2006;147(8):839-53.
2006: Thomas H Gillingwater; Thomas M Wishart; Philip E Chen; Jane E Haley; Kevin Robertson; Stephen H-F MacDonald; Susan Middleton; Kolja Wawrowski; Michael Shipston; Shlomo Melmed; David J A Wyllie; Paul A Skehel; Michael P Coleman; Richard R Ribchester
The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells.
Human molecular genetics 2006;15(4):625-35.
2005: Catherine Vickers; Kirsten S Dickson; David J A Wyllie
Induction and maintenance of late-phase long-term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones.
The Journal of physiology 2005;568(Pt 3):803-13.
2005: Kevin Erreger; Matthew T Geballe; Shashank M Dravid; James P Snyder; David J A Wyllie; Stephen F Traynelis
Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(34):7858-66.
2005: Philip E Chen; Matthew T Geballe; Phillip J Stansfeld; Alexander R Johnston; Hongjie Yuan; Amanda L Jacob; James P Snyder; Stephen F Traynelis; David J A Wyllie
Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling.
Molecular pharmacology 2005;67(5):1470-84.
2005: Kevin Erreger; Shashank M Dravid; Tue G Banke; David J A Wyllie; Stephen F Traynelis
Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles.
The Journal of physiology 2005;563(Pt 2):345-58.
2004: Philip E Chen; Alexander R Johnston; M H Selina Mok; Ralf Schoepfer; David J A Wyllie
Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors.
The Journal of physiology 2004;558(Pt 1):45-58.
2004: Kevin Erreger; Philip E Chen; David J A Wyllie; Stephen F Traynelis
Glutamate receptor gating.
Critical reviews in neurobiology 2004;16(3):187-224.
2000: L C Anson; Ralf Schoepfer; David Colquhoun; David J A Wyllie
Single-channel analysis of an NMDA receptor possessing a mutation in the region of the glutamate binding site.
The Journal of physiology 2000;527 Pt 2():225-37.
2000: Charu Misra; Stephen G Brickley; David J A Wyllie; Stuart G Cull-Candy
Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells.
The Journal of physiology 2000;525 Pt 2():299-305.
1998: David J A Wyllie; P Béhé; David Colquhoun
Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors.
The Journal of physiology 1998;510 ( Pt 1)():1-18.
1998: L C Anson; Philip E Chen; David J A Wyllie; David Colquhoun; Ralf Schoepfer
Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(2):581-9.
1997: Alasdair J Gibb; David J A Wyllie
Single cell RT-PCR reaches out to the NMDA receptor.
The Journal of physiology 1997;499(Pt 1):1.
1996: David J A Wyllie; P Béhé; M Nassar; Ralf Schoepfer; David Colquhoun
Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes.
Proceedings. Biological sciences / The Royal Society 1996;263(1373):1079-86.
1995: P Béhé; P Stern; David J A Wyllie; M Nassar; Ralf Schoepfer; David Colquhoun
Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors.
Proceedings. Biological sciences / The Royal Society 1995;262(1364):205-13.
1994: David J A Wyllie; Stuart G Cull-Candy
A comparison of non-NMDA receptor channels in type-2 astrocytes and granule cells from rat cerebellum.
The Journal of physiology 1994;475(1):95-114.
1993: David J A Wyllie; Stephen F Traynelis; Stuart G Cull-Candy
Evidence for more than one type of non-NMDA receptor in outside-out patches from cerebellar granule cells of the rat.
The Journal of physiology 1993;463():193-226.
1991: Stuart G Cull-Candy; David J A Wyllie
Glutamate-receptor channels in mammalian glial cells.
Annals of the New York Academy of Sciences 1991;633():458-74.
1991: David J A Wyllie; A Mathie; C J Symonds; Stuart G Cull-Candy
Activation of glutamate receptors and glutamate uptake in identified macroglial cells in rat cerebellar cultures.
The Journal of physiology 1991;432():235-58.