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Matthias Wymann

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Dominik Erhart; Beat Ernst; Olivier Jacques; Matthias B Wittwer; Florent Beaufils; Edwin Constable; Mirjam Zimmermann; Marketa Zvelebil; Matthias P Wymann
Chemical development of intracellular protein heterodimerizers.
C Schmidt; N Schneble; Matthias P Wymann; R Bauer; E Hirsch; R Marone; Jörg P Müller; A Perino; Sergei D Rybalkin; Reinhard Wetzker
Phosphoinositide 3-kinase γ mediates microglial phagocytosis via lipid kinase-independent control of cAMP.
Matthias P Wymann; Giovanni Solinas
Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors.

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2013: Dominik Erhart; Beat Ernst; Olivier Jacques; Matthias B Wittwer; Florent Beaufils; Edwin Constable; Mirjam Zimmermann; Marketa Zvelebil; Matthias P Wymann
Chemical development of intracellular protein heterodimerizers.
Chemistry & biology 2013;20(4):549-57.
2013: C Schmidt; N Schneble; Matthias P Wymann; R Bauer; E Hirsch; R Marone; Jörg P Müller; A Perino; Sergei D Rybalkin; Reinhard Wetzker
Phosphoinositide 3-kinase γ mediates microglial phagocytosis via lipid kinase-independent control of cAMP.
Neuroscience 2013;233():44-53.
2013: Matthias P Wymann; Giovanni Solinas
Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors.
Annals of the New York Academy of Sciences 2013;1280():44-7.
2013: Manoj K Barthwal; Thomas Bohnacker; Matthias P Wymann; Qing Xu; Joshua J Anzinger; Howard S Kruth
Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation.
PloS one 2013;8(3):e58054.
2012: Stephanie J Harris; Loredana Ciuclan; Peter M Finan; Christoph Walker; Stephen G Ward; John Westwick; Matthias P Wymann; Matthew J Thomas
Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels.
European journal of immunology 2012;42(12):3394-404.
2012: Matthias P Wymann; Carsten Schultz
The chemical biology of phosphoinositide 3-kinases.
Chembiochem : a European journal of chemical biology 2012;13(14):2022-35.
2012: Christoph A Reichel; Bernd Uhl; Matthias P Wymann; Stefan Zahler; Gabriele Zuchtriegel; Nina Berberich; Bruno Luckow; Daniel Puhr-Westerheide; Fritz Krombach
C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms.
Blood 2012;120(4):880-90.
2012: A Fougerat; Stéphanie Gayral; E Hirsch; N Malet; B Perret; L O Martinez; N F Smirnova; Matthias P Wymann; M Douillon; Muriel Laffargue
Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration.
British journal of pharmacology 2012;166(5):1643-53.
2011: Barbara Becattini; Abdul G Dulloo; Romina Marone; Jean-Pierre Montani; Frédéric Preitner; Josiane Seydoux; Bernard Thorens; Matthias P Wymann; Fabio Zani; Denis Arsenijevic; Giovanni Solinas
PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(42):E854-63.
2011: Alessia Perino; Alessandra Ghigo; Enrico Ferrero; Fulvio Morello; Gaetano Santulli; George S Baillie; Federico Damilano; Allan J Dunlop; Catherine Pawson; Romy Walser; Renzo Levi; Fiorella Altruda; Lorenzo Silengo; Lorene K Langeberg; Gitte Neubauer; Stephane Heymans; Giuseppe Lembo; Matthias P Wymann; Reinhard Wetzker; Miles D Houslay; Guido Iaccarino; John D Scott; Emilio Hirsch
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Molecular cell 2011;42(1):84-95.
2011: Matthias P Wymann; Markus R Wenk
Neutral not a loss: phosphoinositides beyond the head group.
Nature methods 2011;8(3):219-20.
2011: Christoph Reichel; Max Lerchenberger; Bernd Uhl; Markus Rehberg; Nina Berberich; Stefan Zahler; Matthias P Wymann; Fritz Krombach
Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.
PloS one 2011;6(2):e17229.
2010: Elisa Ciraolo; Fulvio Morello; Robin M Hobbs; Frieder Wolf; Romina Marone; Manuela Iezzi; Xiaoyun Lu; Giulio Mengozzi; Fiorella Altruda; Giovanni Sorba; Kaomei Guan; Pier Paolo Pandolfi; Matthias P Wymann; Emilio Hirsch
Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.
Molecular biology of the cell 2010;21(5):704-11.
2009: Barbara Kurig; Aliaksei Shymanets; Thomas Bohnacker; Carsten Brock; Mohammad Reza Ahmadian; Michael Schaefer; Antje Gohla; Christian Harteneck; Matthias P Wymann; Elisabeth Jeanclos; Bernd Nürnberg
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20312-7.
2009: Sandra Santos-Sierra; Sachin D Deshmukh; Julia Kalnitski; Peter Küenzi; Matthias P Wymann; Douglas T Golenbock; Philipp Henneke
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.
The EMBO journal 2009;28(14):2018-27.
2009: Romina Marone; Dominik Erhart; Ann C Mertz; Thomas Bohnacker; Christian Schnell; Vladimir Cmiljanovic; Frédéric Stauffer; Carlos Garcia-Echeverria; Bernd Giese; Sauveur-Michel Maira; Matthias P Wymann
Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.
Molecular cancer research : MCR 2009;7(4):601-13.
2009: Laura Barberis; Christian Pasquali; Dominique Bertschy-Meier; Alessandra Cuccurullo; Carlotta Costa; Chiara Ambrogio; FRancis VILBOIS; Roberto Chiarle; Matthias P Wymann; Fiorella Altruda; Christian Rommel; Emilio Hirsch
Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin.
European journal of immunology 2009;39(4):1136-46.
2009: Matthew Thomas; Matthew J Edwards; Elzbieta Sawicka; Nicholas Duggan; Emilio Hirsch; Matthias P Wymann; Charles Owen; Alexandre Trifilieff; Christoph Walker; John Westwick; Peter Finan
Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation.
Immunology 2009;126(3):413-22.
2009: Thomas Bohnacker; Romina Marone; Emilie Collmann; Ronan Calvez; Emilio Hirsch; Matthias P Wymann
PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.
Science signaling 2009;2(74):ra27.
2008: Rosaline C-Y Hui; Ana R Gomes; Demetra Constantinidou; Joana R Costa; Christina T Karadedou; Silvia Fernandez de Mattos; Matthias P Wymann; Jan J Brosens; Almut Schulze; Eric W-F Lam
The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression.
Molecular and cellular biology 2008;28(19):5886-98.
2008: Anne Fougerat; Stéphanie Gayral; Pierre Gourdy; Alexia Schambourg; Thomas Rückle; Matthias K Schwarz; Christian Rommel; Emilio Hirsch; jean francois arnal; Jean-Pierre Salles; Bertrand PERRET; Monique Breton-Douillon; Matthias P Wymann; Muriel Laffargue
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.
Circulation 2008;117(10):1310-7.
2008: Matthias P Wymann; Roger Schneiter
Lipid signalling in disease.
Nature reviews. Molecular cell biology 2008;9(2):162-76.
2008: Elisa Ciraolo; Manuela Iezzi; Romina Marone; Stefano Marengo; Claudia Curcio; Carlotta Costa; Ornella Azzolino; Cristiano Gonella; Cristina Rubinetto; Haiyan Wu; Walter Dastrù; Erica L Martin; Lorenzo Silengo; Fiorella Altruda; Emilia Turco; Letizia Lanzetti; Piero Musiani; Thomas Rückle; Christian Rommel; Jonathan M Backer; Guido Forni; Matthias P Wymann; Emilio Hirsch
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.
Science signaling 2008;1(36):ra3.
2008: Romina Marone; Vladimir Cmiljanovic; Bernd Giese; Matthias P Wymann
Targeting phosphoinositide 3-kinase: moving towards therapy.
Biochimica et biophysica acta 2008;1784(1):159-85.
2007: Isabela Alcázar; Miriam Marqués; Amit Kumar; Emilio Hirsch; Matthias P Wymann; Ana Carrera; Domingo F Barber
Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation.
The Journal of experimental medicine 2007;204(12):2977-87.
2007: Hong Ji; Felix Rintelen; Caroline Waltzinger; Dominique Bertschy Meier; Antonio Bilancio; Wayne Pearce; Emilio Hirsch; Matthias P Wymann; Thomas Rückle; Montserrat Camps; Bart Vanhaesebroeck; Klaus Okkenhaug; Christian Rommel
Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.
Blood 2007;110(8):2940-7.
2007: Carlotta Costa; Laura Barberis; Chiara Ambrogio; Andrea D Manazza; Enrico Patrucco; Ornella Azzolino; Paul O Neilsen; Elisa Ciraolo; Fiorella Altruda; Glenn D Prestwich; Roberto Chiarle; Matthias P Wymann; Anne Ridley; Emilio Hirsch
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(36):14354-9.
2007: César Nombela-Arrieta; Thorsten R Mempel; Silvia F Soriano; Irina B Mazo; Matthias P Wymann; Emilio Hirsch; Carlos Martínez-A; Yoshinori Fukui; Ulrich H von Andrian; Jens V Stein
A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress.
The Journal of experimental medicine 2007;204(3):497-510.
2007: Gordon ferguson; Laura Milne; Suhasini Kulkarni; Takehiko Sasaki; Simon Walker; Simon Andrews; Tom Crabbe; Peter Finan; Gareth Jones; Shaun Jackson; Montserrat Camps; Christian Rommel; Matthias P Wymann; Emilio Hirsch; Phillip T Hawkins; Len Stephens
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.
Nature cell biology 2007;9(1):86-91.
2006: Vincenzo Lionetti; Alberto Lisi; Enrico Patrucco; Paolo De Giuli; Maria Giovanna Milazzo; Simone Ceci; Matthias P Wymann; Annalisa Lena; Vittorio Gremigni; Vito Fanelli; Emilio Hirsch; V Marco Ranieri
Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury.
Critical care medicine 2006;34(1):134-41.
2006: Domingo F Barber; Almira Bartolomé; Carmen Hernandez; Juana M Flores; Cristina Fernandez-Arias; Luis Rodríguez-Borlado; Emilio Hirsch; Matthias P Wymann; Dimitrios Balomenos; Ana Carrera
Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):589-93.
2005: Montserrat Camps; Thomas Rückle; Hong Ji; Vittoria Ardissone; Felix Rintelen; Jeffrey Shaw; Chiara Ferrandi; Christian Chabert; Corine Gillieron; Bernard Françon; Thierry Martin; Denise Gretener; Dominique Perrin; Didier Leroy; Pierre-Alain Vitte; Emilio Hirsch; Matthias P Wymann; Rocco Cirillo; Matthias K Schwarz; Christian Rommel
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
Nature medicine 2005;11(9):936-43.
2005: Louise M C Webb; Elena Vigorito; Matthias P Wymann; Emilio Hirsch; Martin Turner
Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):2783-7.
2005: Alison M Condliffe; Keith Davidson; Karen E Anderson; Chris D Ellson; Tom Crabbe; Klaus Okkenhaug; Bart Vanhaesebroeck; Martin Turner; Louise Webb; Matthias P Wymann; Emilio Hirsch; Thomas Ruckle; Montserrat Camps; Christian Rommel; Shaun P Jackson; Edwin R Chilvers; Len R Stephens; Phillip T Hawkins
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Blood 2005;106(4):1432-40.
2005: franz wittwer; Malika Jaquenoud; Walter Brogiolo; Marcel Zarske; Philipp Wüstemann; Rafael Fernandez; Hugo Stocker; Matthias P Wymann; Ernst Hafen
Susi, a negative regulator of Drosophila PI3-kinase.
Developmental cell 2005;8(6):817-27.
2005: Carmine Vecchione; Enrico Patrucco; Gennaro Marino; Laura Barberis; Roberta Poulet; Alessandra Aretini; Angelo Maffei; Maria Teresa Gentile; marianna storto; Ornella Azzolino; Mara Brancaccio; Gian Luca Colussi; Umberto Bettarini; Fiorella Altruda; Lorenzo Silengo; Guido Tarone; Matthias P Wymann; Emilio Hirsch; Giuseppe Lembo
Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma.
The Journal of experimental medicine 2005;201(8):1217-28.
2005: Matthias P Wymann; Romina Marone
Phosphoinositide 3-kinase in disease: timing, location, and scaffolding.
Current opinion in cell biology 2005;17(2):141-9.
2005: Matthew J Thomas; Alexandra Smith; Denise H Head; Laura Milne; Andrew Nicholls; Wayne Pearce; Bart Vanhaesebroeck; Matthias P Wymann; Emilio Hirsch; Alexandre Trifilieff; Christoph Walker; Peter Finan; John Westwick
Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases.
European journal of immunology 2005;35(4):1283-91.
2005: Giuseppe Alloatti; andrea marcantoni; Renzo Levi; Maria Pia Gallo; Lorenzo Del Sorbo; Enrico Patrucco; Laura Barberis; Daniela Malan; Ornella Azzolino; Matthias P Wymann; Emilio Hirsch; Giuseppe Montrucchio
Phosphoinositide 3-kinase gamma controls autonomic regulation of the mouse heart through Gi-independent downregulation of cAMP level.
FEBS letters 2005;579(1):133-40.
2004: Enrico Lupia; Alberto Goffi; Paolo De Giuli; Ornella Azzolino; Ornella Bosco; Enrico Patrucco; Maria Cristina Vivaldo; Marco Ricca; Matthias P Wymann; Emilio Hirsch; Giuseppe Montrucchio; Giorgio Emanuelli
Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis.
The American journal of pathology 2004;165(6):2003-11.
2004: Giovanni Solinas; Serge Summermmatter; Davide Mainieri; Marcel Gubler; Luciano Pirola; Matthias P Wymann; Sandro Rusconi; Jean-Pierre Montani; Josiane Seydoux; Abdul G Dulloo
The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation.
FEBS letters 2004;577(3):539-44.
2004: Annalisa Del Prete; William Vermi; Erica Dander; Karel Otero; Laura Barberis; Walter Luini; Sergio Bernasconi; Marina Sironi; Amerigo Santoro; Cecilia Garlanda; Fabio Facchetti; Matthias P Wymann; Annunciata Vecchi; Emilio Hirsch; Alberto Mantovani; Silvano Sozzani
Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice.
The EMBO journal 2004;23(17):3505-15.
2004: Enrico Patrucco; Antonella Notte; Laura Barberis; Giulio Selvetella; Angelo Maffei; Mara Brancaccio; Stefano Marengo; Giovanni Russo; Ornella Azzolino; Sergei D Rybalkin; Lorenzo Silengo; Fiorella Altruda; Reinhard Wetzker; Matthias P Wymann; Giuseppe Lembo; Emilio Hirsch
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.
Cell 2004;118(3):375-87.
2004: Regina Pietrucha; Ignacio Rubio; Matthias P Wymann; Reinhard Wetzker
Phosphoinositide 3-kinase gamma mediates Jun kinase activation via its lipid-kinase activity.
Advances in enzyme regulation 2004;44():299-308.
2003: Giuseppe Alloatti; Renzo Levi; Daniela Malan; Lorenzo Del Sorbo; Ornella Bosco; Laura Barberis; andrea marcantoni; Ivano Bedendi; Claudia Penna; Ornella Azzolino; Fiorella Altruda; Matthias P Wymann; Emilio Hirsch; Giuseppe Montrucchio
Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility.
Cardiovascular research 2003;60(2):242-9.
2003: Gareth E Jones; Elena Prigmore; Ronan Calvez; Catherine Hogan; Graham A Dunn; Emilio Hirsch; Matthias P Wymann; Anne J Ridley
Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1.
Experimental cell research 2003;290(1):120-31.
2003: Matthias P Wymann; Marketa Zvelebil; Muriel Laffargue
Phosphoinositide 3-kinase signalling--which way to target?
Trends in pharmacological sciences 2003;24(7):366-76.
2003: Heng-Ye Man; Qinhua Wang; Wei-Yang Lu; William Ju; Gholamreza Ahmadian; Lidong Liu; Sandra D'Souza; Tak Pan Wong; Changiz Taghibiglou; Jie Lu; Lawrence E Becker; Lin Pei; Fang Liu; Matthias P Wymann; John F MacDonald; Yu Tian Wang
Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons.
Neuron 2003;38(4):611-24.
2003: Luis Rodríguez-Borlado; Domingo F Barber; Carmen Hernández; Miguel A Rodríguez-Marcos; Arsenio Sánchez; Emilio Hirsch; Matthias P Wymann; Carlos Martínez-A; Ana Carrera
Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4475-82.
2003: Matthias P Wymann; K Björklöf; Ronan Calvez; Peter Finan; M Thomast; Alexandre Trifilieff; Maryse Barbier; Fiorella Altruda; Emilio Hirsch; Muriel Laffargue
Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy.
Biochemical Society transactions 2003;31(Pt 1):275-80.
2003: Paolo Lova; Simona Paganini; Emilio Hirsch; Laura Barberis; Matthias P Wymann; Fabiola Sinigaglia; Carlo L Balduini; Mauro Torti
A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B.
The Journal of biological chemistry 2003;278(1):131-8.
2002: Michael A Crackower; Gavin Y Oudit; Ivona Kozieradzki; Renu Sarao; Hui Sun; Takehiko Sasaki; Emilio Hirsch; Akira Suzuki; Tetsuo Shioi; Junko Irie-Sasaki; Rajan Sah; Hai-Ying M Cheng; Vitalyi O Rybin; Giuseppe Lembo; Luigi Fratta; Antonio J Oliveira-dos-Santos; Jeffery L Benovic; C Ronald Kahn; Seigo Izumo; Susan F Steinberg; Matthias P Wymann; Peter H Backx; Josef M Penninger
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
Cell 2002;110(6):737-49.
2002: Sean Oldham; Hugo Stocker; Muriel Laffargue; franz wittwer; Matthias P Wymann; Ernst Hafen
The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels.
Development (Cambridge, England) 2002;129(17):4103-9.
2002: Philipp Berger; Sonja Bonneick; Susan Willi; Matthias P Wymann; Ueli Suter
Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1.
Human molecular genetics 2002;11(13):1569-79.
2002: Lorenz Roggo; Vincent Bernard; Attila L Kovacs; Ann M Rose; Fabienne Savoy; Monique Zetka; Matthias P Wymann; Fritz Müller
Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane.
The EMBO journal 2002;21(7):1673-83.
2002: Hugo Stocker; Mirjana Andjelkovic; Sean Oldham; Muriel Laffargue; Matthias P Wymann; Brian A Hemmings; Ernst Hafen
Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.
Science (New York, N.Y.) 2002;295(5562):2088-91.
2002: Muriel Laffargue; Ronan Calvez; Peter Finan; Alexandre Trifilieff; Maryse Barbier; Fiorella Altruda; Emilio Hirsch; Matthias P Wymann
Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function.
Immunity 2002;16(3):441-51.
2001: Maryse Barbier; Samir Attoub; Ronan Calvez; Muriel Laffargue; A Jarry; M Mareel; Fiorella Altruda; Christian Gespach; D Wu; B Lu; Emilio Hirsch; Matthias P Wymann
Tumour biology. Weakening link to colorectal cancer?
Nature 2001;413(6858):796.
2001: Emilio Hirsch; Ornella Bosco; P Tropel; Muriel Laffargue; Ronan Calvez; Fiorella Altruda; Matthias P Wymann; Giuseppe Montrucchio
Resistance to thromboembolism in PI3Kgamma-deficient mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):2019-21.
2001: Luciano Pirola; Marketa Zvelebil; G Bulgarelli-Leva; Emmanuel Van Obberghen; Michael D Waterfield; Matthias P Wymann
Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.
The Journal of biological chemistry 2001;276(24):21544-54.
2000: Samir Attoub; V Noe; Luciano Pirola; Erik Bruyneel; Eric Chastre; Marc Mareel; Matthias P Wymann; Christian Gespach
Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(14):2329-38.
2000: Emilio Hirsch; Matthias P Wymann; Enrico Patrucco; Emanuela Tolosano; G Bulgarelli-Leva; Stefano Marengo; Mariano Rocchi; Fiorella Altruda
Analysis of the murine phosphoinositide 3-kinase gamma gene.
Gene 2000;256(1-2):69-81.
2000: EH Walker; Michael E Pacold; Olga Perisic; Len Stephens; Phillip T Hawkins; Matthias P Wymann; Roger L Williams
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.
Molecular cell 2000;6(4):909-19.
2000: Matthias P Wymann; S Sozzani; Fiorella Altruda; A Mantovani; Emilio Hirsch
Lipids on the move: phosphoinositide 3-kinases in leukocyte function.
Immunology today 2000;21(6):260-4.
2000: Emilio Hirsch; VL Katanaev; Cecilia Garlanda; Ornella Azzolino; Luciano Pirola; Lorenzo Silengo; S Sozzani; A Mantovani; Fiorella Altruda; Matthias P Wymann
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.
Science (New York, N.Y.) 2000;287(5455):1049-53.
1999: Matthias P Wymann; Luciano Pirola; VL Katanaev; G Bulgarelli-Leva
Phosphoinositide 3-kinase signalling: no lipids.
Biochemical Society transactions 1999;27(4):629-34.
1998: Matthias P Wymann; Luciano Pirola
Structure and function of phosphoinositide 3-kinases.
Biochimica et biophysica acta 1998;1436(1-2):127-50.
1998: VL Katanaev; Matthias P Wymann
Microquantification of cellular and in vitro F-actin by rhodamine phalloidin fluorescence enhancement.
Analytical biochemistry 1998;264(2):185-90.
1998: Tzvetanka Bondeva; Luciano Pirola; G Bulgarelli-Leva; Ignacio Rubio; Reinhard Wetzker; Matthias P Wymann
Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK.
Science (New York, N.Y.) 1998;282(5387):293-6.
1998: VL Katanaev; Matthias P Wymann
GTPgammaS-induced actin polymerisation in vitro: ATP- and phosphoinositide-independent signalling via Rho-family proteins and a plasma membrane-associated guanine nucleotide exchange factor.
Journal of cell science 1998;111 ( Pt 11)():1583-94.
1997: Stefka Stoyanova; G Bulgarelli-Leva; Cornelia Kirsch; Theodor Hanck; Reinhard Klinger; Reinhard Wetzker; Matthias P Wymann
Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.
The Biochemical journal 1997;324 ( Pt 2)():489-95.
1996: Matthias P Wymann; G Bulgarelli-Leva; Marketa Zvelebil; Luciano Pirola; Bart Vanhaesebroeck; Michael D Waterfield; George Panayotou
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.
Molecular and cellular biology 1996;16(4):1722-33.
1995: Matthias P Wymann; P Kernen; Vinzenz von Tscharner; P C Tai; C J Spry; Marco Baggiolini
Activation of the respiratory burst in eosinophil leucocytes--a transduction sequence decoupled from cytosolic Ca2+ rise.
European journal of clinical investigation 1995;25(1):25-31.
1994: M Thelen; Matthias P Wymann; H Langen
Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4960-4.
1994: Matthias P Wymann; A Arcaro
Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts.
The Biochemical journal 1994;298 Pt 3():517-20.
1993: A Arcaro; Matthias P Wymann
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.
The Biochemical journal 1993;296 ( Pt 2)():297-301.
1993: B Johansson; Matthias P Wymann; K Holmgren-Peterson; Karl-Eric Magnusson
N-formyl peptide receptors in human neutrophils display distinct membrane distribution and lateral mobility when labeled with agonist and antagonist.
The Journal of cell biology 1993;121(6):1281-9.
1991: Per Follin; Matthias P Wymann; B Dewald; M Ceska; Claes Dahlgren
Human neutrophil migration into skin chambers is associated with production of NAP-1/IL8 and C5a.
European journal of haematology 1991;47(1):71-6.
1991: P Kernen; Matthias P Wymann; Vinzenz von Tscharner; D A Deranleau; P C Tai; C J Spry; Clemens Dahinden; Marco Baggiolini
Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils.
The Journal of clinical investigation 1991;87(6):2012-7.
1990: Marco Baggiolini; Matthias P Wymann
Turning on the respiratory burst.
Trends in biochemical sciences 1990;15(2):69-72.
1990: Matthias P Wymann; P Kernen; Torbjörn Bengtsson; Tommy Andersson; Marco Baggiolini; D A Deranleau
Corresponding oscillations in neutrophil shape and filamentous actin content.
The Journal of biological chemistry 1990;265(2):619-22.
1989: B Dewald; M Thelen; Matthias P Wymann; Marco Baggiolini
Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils.
The Biochemical journal 1989;264(3):879-84.
1989: Matthias P Wymann; P Kernen; D A Deranleau; Marco Baggiolini
Respiratory burst oscillations in human neutrophils and their correlation with fluctuations in apparent cell shape.
The Journal of biological chemistry 1989;264(27):15829-34.
1989: Marco Baggiolini; D A Deranleau; B Dewald; M Thelen; Vinzenz von Tscharner; Matthias P Wymann
[Properties and activation mechanism of neutrophilic leukocytes].
Arzneimittel-Forschung 1989;39(1A):177-80.
1988: Torbjörn Bengtsson; Ingemar Rundquist; Olle Stendahl; Matthias P Wymann; Tommy Andersson
Increased breakdown of phosphatidylinositol 4,5-bisphosphate is not an initiating factor for actin assembly in human neutrophils.
The Journal of biological chemistry 1988;263(33):17385-9.
1987: Matthias P Wymann; Vinzenz von Tscharner; D A Deranleau; Marco Baggiolini
The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process.
The Journal of biological chemistry 1987;262(25):12048-53.
1987: Matthias P Wymann; Vinzenz von Tscharner; D A Deranleau; Marco Baggiolini
Chemiluminescence detection of H2O2 produced by human neutrophils during the respiratory burst.
Analytical biochemistry 1987;165(2):371-8.
1987: Matthias P Wymann; P Kernen; D A Deranleau; B Dewald; Vinzenz von Tscharner; Marco Baggiolini
Oscillatory motion in human neutrophils responding to chemotactic stimuli.
Biochemical and biophysical research communications 1987;147(1):361-8.