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David Wynford-Thomas
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33
Wyllie, Fiona
23
Bond, Jane
14
Haughton, Michèle
13
Lemoine, Nicholas
11
Jones, Christopher
11
Gire, Véronique
9
Rowson, Jan
9
Kipling, David
8
Ivan, Mircea
8
Blaydes, JP
4
Ludgate, Marian
3
Skinner, Julia
3
Smith, Paul
3
Bond, Jane
3
Bounacer, Ali
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All Publications
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2009: Hibma Merilyn H; Real Nicola C; Wiles Anna; Dobson-Le Deirdre; Dix Brett R; Wynford-Thomas David; Braithwaite Antony W; Royds Janice A
Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells.
Virus research 2009;145(1):112-20.
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2007: Bond Jane A; Gescher Andreas J; Verschoyle Richard D; Lemoine Nicholas R; Errington Rachel; Wiltshire Marie; Smith Paul J; Wynford-Thomas David
Cytotoxic action of phorbol esters on human pancreatic cancer cells.
International journal of cancer. Journal international du cancer 2007;121(7):1445-54.
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2007: Ball Elizabeth; Bond Jane; Franc Brigitte; Demicco Catherine; Wynford-Thomas David
An immunohistochemical study of p16(INK4a) expression in multistep thyroid tumourigenesis.
European journal of cancer (Oxford, England : 1990) 2007;43(1):194-201.
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2006: Gray-Schopfer V C; Cheong S C; Chong H; Chow J; Moss T; Abdel-Malek Z A; Marais R; Wynford-Thomas D; Bennett D C
Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
British journal of cancer 2006;95(4):496-505.
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2006: Di Cristofaro Julie; Marcy Myriam; Vasko Vasily; Sebag Frédéric; Fakhry Nicolas; Wynford-Thomas David; De Micco Catherine
Molecular genetic study comparing follicular variant versus classic papillary thyroid carcinomas: association of N-ras mutation in codon 61 with follicular variant.
Human pathology 2006;37(7):824-30.
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2006: Eszlinger Markus; Krohn Knut; Beck Martin; Kipling David; Forbes-Robertson Sarah; Läuter Jürgen; Toenjes Anke; Wynford-Thomas David; Paschke Ralf
Comparison of differential gene expression of hot and cold thyroid nodules with primary epithelial cell culture models by investigation of co-regulated gene sets.
Biochimica et biophysica acta 2006;1763(3):263-71.
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2006: Poghosyan Zaruhi; Wynford-Thomas David
Analysis of Ras transformation of human thyroid epithelial cells.
Methods in enzymology 2006;407():648-60.
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2005: Ridley Andrew J; Colley James; Wynford-Thomas David; Jones Christopher J
Characterisation of novel mutations in Cockayne syndrome type A and xeroderma pigmentosum group C subjects.
Journal of human genetics 2005;50(3):151-4.
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2004: Bounacer Ali; McGregor Alex; Skinner Julia; Bond Jane; Poghosyan Zara; Wynford-Thomas David
Mutant ras-induced proliferation of human thyroid epithelial cells requires three effector pathways.
Oncogene 2004;23(47):7839-45.
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2004: Skinner Julia; Bounacer Ali; Bond Jane A; Haughton Michele F; deMicco Catherine; Wynford-Thomas David
Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis.
Oncogene 2004;23(35):5994-9.
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2004: Gire Véronique; Roux Pierre; Wynford-Thomas David; Brondello Jean-Marc; Dulic Vjekoslav
DNA damage checkpoint kinase Chk2 triggers replicative senescence.
The EMBO journal 2004;23(13):2554-63.
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2004: Preto Ana; Singhrao Sim K; Haughton Michele F; Kipling David; Wynford-Thomas David; Jones Christopher J
Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy.
Oncogene 2004;23(23):4136-45.
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2004: Bond Jane; Jones Christopher; Haughton Michele; DeMicco Catherine; Kipling David; Wynford-Thomas David
Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation.
Experimental cell research 2004;292(1):151-6.
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2003: Fuhrer D; Lewis M D; Alkhafaji F; Starkey K; Paschke R; Wynford-Thomas D; Eggo M; Ludgate M
Biological activity of activating thyroid-stimulating hormone receptor mutants depends on the cellular context.
Endocrinology 2003;144(9):4018-30.
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2003: Evans Rebecca J; Wyllie Fiona S; Wynford-Thomas David; Kipling David; Jones Christopher J
A P53-dependent, telomere-independent proliferative life span barrier in human astrocytes consistent with the molecular genetics of glioma development.
Cancer research 2003;63(16):4854-61.
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2003: Sviderskaya Elena V; Gray-Schopfer Vanessa C; Hill Simon P; Smit Nico P; Evans-Whipp Tracy J; Bond Jane; Hill Lucy; Bataille Veronique; Peters Gordon; Kipling David; Wynford-Thomas David; Bennett Dorothy C
p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.
Journal of the National Cancer Institute 2003;95(10):723-32.
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2003: Wyllie Fiona; Haughton Michele; Bartek Jiri; Rowson Jan; Wynford-Thomas David
Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21(WAF1) expression.
Experimental cell research 2003;285(2):236-42.
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2003: Davis Terence; Singhrao Sim K; Wyllie Fiona S; Haughton Michele F; Smith Paul J; Wiltshire Marie; Wynford-Thomas David; Jones Christopher J; Faragher Richard G A; Kipling David
Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms.
Journal of cell science 2003;116(Pt 7):1349-57.
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2003: Baird Duncan M; Rowson Jan; Wynford-Thomas David; Kipling David
Extensive allelic variation and ultrashort telomeres in senescent human cells.
Nature genetics 2003;33(2):203-7.
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2002: Morris Mark; Hepburn Peter; Wynford-Thomas David
Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function.
Oncogene 2002;21(27):4277-88.
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2001: Matthews P; Jones C J; Skinner J; Haughton M; de Micco C; Wynford-Thomas D
Telomerase activity and telomere length in thyroid neoplasia: biological and clinical implications.
The Journal of pathology 2001;194(2):183-93.
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2001: Jasani B; Jones C J; Radu C; Wynford-Thomas D; Navabi H; Mason M; Adams M; Gibbs A
Simian virus 40 detection in human mesothelioma: reliability and significance of the available molecular evidence.
Frontiers in bioscience : a journal and virtual library 2001;6():E12-22.
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2000: Jones C J; Kipling D; Morris M; Hepburn P; Skinner J; Bounacer A; Wyllie F S; Ivan M; Bartek J; Wynford-Thomas D; Bond J A
Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells.
Molecular and cellular biology 2000;20(15):5690-9.
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2000: Gire V; Marshall C; Wynford-Thomas D
PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS.
Oncogene 2000;19(19):2269-76.
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2000: Webley K; Bond J A; Jones C J; Blaydes J P; Craig A; Hupp T; Wynford-Thomas D
Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage.
Molecular and cellular biology 2000;20(8):2803-8.
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2000: Gire V; Wynford-Thomas D
RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation.
Oncogene 2000;19(6):737-44.
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2000: Wyllie F S; Jones C J; Skinner J W; Haughton M F; Wallis C; Wynford-Thomas D; Faragher R G; Kipling D
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts.
Nature genetics 2000;24(1):16-7.
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1999: Gire V; Marshall C J; Wynford-Thomas D
Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras.
Oncogene 1999;18(34):4819-32.
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1999: Ludgate M; Gire V; Crisp M; Ajjan R; Weetman A; Ivan M; Wynford-Thomas D
Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells.
Oncogene 1999;18(34):4798-807.
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1999: Bond J A; Webley K; Wyllie F S; Jones C J; Craig A; Hupp T; Wynford-Thomas D
p53-Dependent growth arrest and altered p53-immunoreactivity following metabolic labelling with 32P ortho-phosphate in human fibroblasts.
Oncogene 1999;18(25):3788-92.
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1999: Bond J A; Haughton M F; Rowson J M; Smith P J; Gire V; Wynford-Thomas D; Wyllie F S
Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis.
Molecular and cellular biology 1999;19(4):3103-14.
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1999: Wyllie F S; Haughton M F; Rowson J M; Wynford-Thomas D
Human thyroid cancer cells as a source of iso-genic, iso-phenotypic cell lines with or without functional p53.
British journal of cancer 1999;79(7-8):1111-20.
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1999: Wynford-Thomas D
Cellular senescence and cancer.
The Journal of pathology 1999;187(1):100-11.
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1999: Wynford-Thomas D
[Molecular basis of tumors arising in thyroid follicular cells]
Annales de chirurgie 1999;53(3):237-43.
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1998: Parry E M; Ulucan H; Wyllie F S; Wynford-Thomas D; Parry J M
Segregational fidelity of chromosomes in human thyroid tumour cells.
Chromosoma 1998;107(6-7):491-7.
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1998: Fischer A H; Bond J A; Taysavang P; Battles O E; Wynford-Thomas D
Papillary thyroid carcinoma oncogene (RET/PTC) alters the nuclear envelope and chromatin structure.
The American journal of pathology 1998;153(5):1443-50.
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1998: Hall-Jackson C A; Jones T; Eccles N G; Dawson T P; Bond J A; Gescher A; Wynford-Thomas D
Induction of cell death by stimulation of protein kinase C in human epithelial cells expressing a mutant ras oncogene: a potential therapeutic target.
British journal of cancer 1998;78(5):641-51.
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1998: Blaydes J P; Wynford-Thomas D
The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.
Oncogene 1998;16(25):3317-22.
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1998: Soares P; Fonseca E; Wynford-Thomas D; Sobrinho-Simões M
Sporadic ret-rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms?
The Journal of pathology 1998;185(1):71-8.
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1998: Jones C J; Soley A; Skinner J W; Gupta J; Haughton M F; Wyllie F S; Schlumberger M; Bacchetti S; Wynford-Thomas D
Dissociation of telomere dynamics from telomerase activity in human thyroid cancer cells.
Experimental cell research 1998;240(2):333-9.
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1998: Gire V; Wynford-Thomas D
Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies.
Molecular and cellular biology 1998;18(3):1611-21.
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1998: Gibbs A R; Jasani B; Pepper C; Navabi H; Wynford-Thomas D
SV40 DNA sequences in mesotheliomas.
Developments in biological standardization 1998;94():41-5.
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1998: Gire V; Wynford-Thomas D
[Origin and progression of thyroid epithelial tumors: molecular and cellular mechanisms]
Archives d'anatomie et de cytologie pathologiques 1998;46(1-2):11-8.
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1997: Ivan M; Ludgate M; Gire V; Bond J A; Wynford-Thomas D
An amphotropic retroviral vector expressing a mutant gsp oncogene: effects on human thyroid cells in vitro.
The Journal of clinical endocrinology and metabolism 1997;82(8):2702-9.
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1997: Crisp M S; Lane C; Halliwell M; Wynford-Thomas D; Ludgate M
Thyrotropin receptor transcripts in human adipose tissue.
The Journal of clinical endocrinology and metabolism 1997;82(6):2003-5.
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1997: Ivan M; Bond J A; Prat M; Comoglio P M; Wynford-Thomas D
Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells.
Oncogene 1997;14(20):2417-23.
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1997: Wynford-Thomas D
Proliferative lifespan checkpoints: cell-type specificity and influence on tumour biology.
European journal of cancer (Oxford, England : 1990) 1997;33(5):716-26.
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1997: Blaydes J P; Gire V; Rowson J M; Wynford-Thomas D
Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.
Oncogene 1997;14(15):1859-68.
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1997: Ham J; Ivan M; Wynford-Thomas D; Scanlon M F
GH3 cells expressing constitutively active Gs alpha (Q227L) show enhanced hormone secretion and proliferation.
Molecular and cellular endocrinology 1997;127(1):41-7.
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1997: Lemoine N R; Wynford-Thomas D
Transfection and transformation of human thyroid epithelial cells.
Methods in molecular biology (Clifton, N.J.) 1997;75():441-7.
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1997: Williams D W; Wynford-Thomas D
Human thyroid epithelial cells.
Methods in molecular biology (Clifton, N.J.) 1997;75():163-72.
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1997: Wynford-Thomas D
Origin and progression of thyroid epithelial tumours: cellular and molecular mechanisms.
Hormone research 1997;47(4-6):145-57.
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1996: Bond J; Haughton M; Blaydes J; Gire V; Wynford-Thomas D; Wyllie F
Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.
Oncogene 1996;13(10):2097-104.
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1996: Wynford-Thomas D
p53: guardian of cellular senescence.
The Journal of pathology 1996;180(2):118-21.
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1996: Bond J A; Oddweig Ness G; Rowson J; Ivan M; White D; Wynford-Thomas D
Spontaneous de-differentiation correlates with extended lifespan in transformed thyroid epithelial cells: an epigenetic mechanism of tumour progression?
International journal of cancer. Journal international du cancer 1996;67(4):563-72.
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1996: Eccles N; Ivan M; Wynford-Thomas D
Mitogenic stimulation of normal and oncogene-transformed human thyroid epithelial cells by hepatocyte growth factor.
Molecular and cellular endocrinology 1996;117(2):247-51.
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1996: Wyllie F S; Haughton M F; Bond J A; Rowson J M; Jones C J; Wynford-Thomas D
S phase cell-cycle arrest following DNA damage is independent of the p53/p21(WAF1) signalling pathway.
Oncogene 1996;12(5):1077-82.
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1996: Blaydes J P; Wynford-Thomas D
Loss of responsiveness to transforming growth factor beta (TGFbeta) is tightly linked to tumorigenicity in a model of thyroid tumour progression.
International journal of cancer. Journal international du cancer 1996;65(4):525-30.
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1996: Jones C J; Shaw J J; Wyllie F S; Gaillard N; Schlumberger M; Wynford-Thomas D
High frequency deletion of the tumour suppressor gene P16INK4a (MTS1) in human thyroid cancer cell lines.
Molecular and cellular endocrinology 1996;116(1):115-9.
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1995: Dawson T; Wynford-Thomas D
Does autocrine growth factor secretion form part of a mechanism which paradoxically protects against tumour development?
British journal of cancer 1995;71(6):1136-41.
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1995: Bond J A; Blaydes J P; Rowson J; Haughton M F; Smith J R; Wynford-Thomas D; Wyllie F S
Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1.
Cancer research 1995;55(11):2404-9.
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1995: Wynford-Thomas D; Bond J A; Wyllie F S; Jones C J
Does telomere shortening drive selection for p53 mutation in human cancer?
Molecular carcinogenesis 1995;12(3):119-23.
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1995: Dawson T P; Radulescu A; Wynford-Thomas D
Expression of mutant p21ras induces insulin-like growth factor 1 secretion in thyroid epithelial cells.
Cancer research 1995;55(4):915-20.
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1995: Blaydes J P; Schlumberger M; Wynford-Thomas D; Wyllie F S
Interaction between p53 and TGF beta 1 in control of epithelial cell proliferation.
Oncogene 1995;10(2):307-17.
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1995: Wyllie F S; Haughton M F; Blaydes J P; Schlumberger M; Wynford-Thomas D
Evasion of p53-mediated growth control occurs by three alternative mechanisms in transformed thyroid epithelial cells.
Oncogene 1995;10(1):49-59.
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1994: Bond J A; Wyllie F S; Wynford-Thomas D
Escape from senescence in human diploid fibroblasts induced directly by mutant p53.
Oncogene 1994;9(7):1885-9.
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1994: Bond J A; Wyllie F S; Rowson J; Radulescu A; Wynford-Thomas D
In vitro reconstruction of tumour initiation in a human epithelium.
Oncogene 1994;9(1):281-90.
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1993: McClure F; Dawson T; Wynford-Thomas D
Construction of an ecotropic retroviral vector expressing human insulin-like growth factor-I.
Journal of molecular endocrinology 1993;11(1):49-57.
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1993: Bond J A; Wyllie F S; Ivan M; Dawson T; Wynford-Thomas D
A variant epithelial sub-population in normal thyroid with high proliferative capacity in vitro.
Molecular and cellular endocrinology 1993;93(2):175-83.
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1993: Wyllie F S; Lemoine N R; Barton C M; Dawson T; Bond J; Wynford-Thomas D
Direct growth stimulation of normal human epithelial cells by mutant p53.
Molecular carcinogenesis 1993;7(2):83-8.
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1993: Wynford-Thomas D
Molecular basis of epithelial tumorigenesis: the thyroid model.
Critical reviews in oncogenesis 1993;4(1):1-23.
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1993: Wynford-Thomas D
In vitro models of thyroid cancer.
Cancer surveys 1993;16():115-34.
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1993: Dawson T; Bond J; Eccles N; Wynford-Thomas D
Toxicity of phorbol esters for human epithelial cells expressing a mutant ras oncogene.
Molecular carcinogenesis 1993;8(4):280-9.
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1992: Wyllie F S; Bond J A; Dawson T; White D; Davies R; Wynford-Thomas D
A phenotypically and karyotypically stable human thyroid epithelial line conditionally immortalized by SV40 large T antigen.
Cancer research 1992;52(10):2938-45.
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1992: Bond J A; Graham G J; Freshney M; Dawson T; Sawhney N; Williams E D; Wynford-Thomas D
Detection and partial purification of a potent mitogenic factor for human thyroid follicular cells.
Molecular and cellular endocrinology 1992;84(1-2):R15-21.
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1992: Bond J; Dawson T; Lemoine N; Wynford-Thomas D
Effect of serum growth factors and phorbol ester on growth and survival of human thyroid epithelial cells expressing mutant ras.
Molecular carcinogenesis 1992;5(2):129-35.
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1992: Burns J S; Blaydes J P; Wright P A; Lemoine L; Bond J A; Williams E D; Wynford-Thomas D
Stepwise transformation of primary thyroid epithelial cells by a mutant Ha-ras oncogene: an in vitro model of tumor progression.
Molecular carcinogenesis 1992;6(2):129-39.
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1991: Wynford-Thomas D
Oncogenes and anti-oncogenes; the molecular basis of tumour behaviour.
The Journal of pathology 1991;165(3):187-201.
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1991: Wright P A; Lemoine N R; Goretzki P E; Wyllie F S; Bond J; Hughes C; Röher H D; Williams E D; Wynford-Thomas D
Mutation of the p53 gene in a differentiated human thyroid carcinoma cell line, but not in primary thyroid tumours.
Oncogene 1991;6(9):1693-7.
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1991: Dawson T P; Wyllie F S; Wynford-Thomas D
In vitro responsiveness to serum growth factors is inversely related to in vivo malignancy in human thyroid epithelial cells.
British journal of cancer 1991;63(6):897-900.
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1991: Wyllie F S; Dawson T; Bond J A; Goretzki P; Game S; Prime S; Wynford-Thomas D
Correlated abnormalities of transforming growth factor-beta 1 response and p53 expression in thyroid epithelial cell transformation.
Molecular and cellular endocrinology 1991;76(1-3):13-21.
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1991: Wright P A; Williams E D; Lemoine N R; Wynford-Thomas D
Radiation-associated and 'spontaneous' human thyroid carcinomas show a different pattern of ras oncogene mutation.
Oncogene 1991;6(3):471-3.
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1990: Wright P A; Wynford-Thomas D
The polymerase chain reaction: miracle or mirage? A critical review of its uses and limitations in diagnosis and research.
The Journal of pathology 1990;162(2):99-117.
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1990: Wynford-Thomas D; Bond J A; Wyllie F S; Burns J S; Williams E D; Jones T; Sheer D; Lemoine N R
Conditional immortalization of human thyroid epithelial cells: a tool for analysis of oncogene action.
Molecular and cellular biology 1990;10(10):5365-77.
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1990: Jasani B; Wyllie F S; Wright P A; Lemoine N R; Williams E D; Wynford-Thomas D
Immunocytochemically detectable TGF-beta associated with malignancy in thyroid epithelial neoplasia.
Growth factors (Chur, Switzerland) 1990;2(2-3):149-55.
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1989: Wyllie F S; Lemoine N R; Williams E D; Wynford-Thomas D
Structure and expression of nuclear oncogenes in multi-stage thyroid tumorigenesis.
British journal of cancer 1989;60(4):561-5.
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1989: Wright P A; Lemoine N R; Mayall E S; Wyllie F S; Hughes D; Williams E D; Wynford-Thomas D
Papillary and follicular thyroid carcinomas show a different pattern of ras oncogene mutation.
British journal of cancer 1989;60(4):576-7.
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1989: Williams N W; Wynford-Thomas D
Oncoprotein p53 expression in normal, immortalized, and transformed mouse fibroblasts.
Experimental cell research 1989;184(2):316-28.
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1989: Burns J S; Lemoine L; Lemoine N R; Williams E D; Wynford-Thomas D
Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.
British journal of cancer 1989;59(5):755-60.
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1989: Wynford-Thomas D; Bond J A; Paterson H
Suppression of transformation and immortality in human/Chinese hamster fibroblast hybrids--a model for suppressor gene isolation.
International journal of cancer. Journal international du cancer 1989;43(2):293-9.
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1989: Lemoine N R; Mayall E S; Wyllie F S; Williams E D; Goyns M; Stringer B; Wynford-Thomas D
High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis.
Oncogene 1989;4(2):159-64.
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1989: Williams D W; Williams E D; Wynford-Thomas D
Evidence for autocrine production of IGF-1 in human thyroid adenomas.
Molecular and cellular endocrinology 1989;61(1):139-43.
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1988: Lemoine N R; Mayall E S; Williams E D; Thurston V; Wynford-Thomas D
Agent-specific ras oncogene activation in rat thyroid tumours.
Oncogene 1988;3(5):541-4.
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1988: Lemoine N R; Mayall E S; Wyllie F S; Farr C J; Hughes D; Padua R A; Thurston V; Williams E D; Wynford-Thomas D
Activated ras oncogenes in human thyroid cancers.
Cancer research 1988;48(16):4459-63.
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1988: Boultwood J; Wyllie F S; Williams E D; Wynford-Thomas D
N-myc expression in neoplasia of human thyroid C-cells.
Cancer research 1988;48(14):4073-7.
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1988: Williams D W; Williams E D; Wynford-Thomas D
Loss of dependence on IGF-1 for proliferation of human thyroid adenoma cells.
British journal of cancer 1988;57(6):535-9.
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1988: Wyllie F S; Wynford-Thomas V; Lemoine N R; Williams G T; Williams E D; Wynford-Thomas D
Ha-ras restriction fragment length polymorphisms in colorectal cancer.
British journal of cancer 1988;57(2):135-8.
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