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Matthew Wyvratt

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Qingmei Hong; Raman K Bakshi; Brenda L Palucki; Min K Park; Zhixiong Ye; Shuwen He; Patrick G Pollard; Iyassu K Sebhat; Jian Liu; Liangqin Guo; Doreen E Cashen; William J Martin; David Weinberg; Tanya MacNeil; Rui Tang; Constantin Tamvakopoulos; Qianping Peng; Randy R Miller; Ralph A Stearns; Howard Y Chen; Airu S Chen; Alison M Strack; Tung M Fong; D Euan MacIntyre; Matthew J Wyvratt; Ravi P Nargund
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.
S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Ronsar Eid; Michael H Fisher; William H Parsons; Matthew J Wyvratt; Kathryn A Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; Ann Weber; Joseph L Duffy
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
Shuwen He; Zhixiong Ye; Peter H Dobbelaar; Raman K Bakshi; Qingmei Hong; James P Dellureficio; Iyassu K Sebhat; Liangqin Guo; Jian Liu; Tianying Jian; Yingjie Lai; Christopher L Franklin; Mikhail Reibarkh; Mark A Holmes; David Weinberg; Tanya MacNeil; Rui Tang; Constantin Tamvakopoulos; Qianping Peng; Randy R Miller; Ralph A Stearns; Howard Y Chen; Airu S Chen; Alison M Strack; Tung M Fong; Matthew J Wyvratt; Ravi P Nargund
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.

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All Publications

2011: Qingmei Hong; Raman K Bakshi; Brenda L Palucki; Min K Park; Zhixiong Ye; Shuwen He; Patrick G Pollard; Iyassu K Sebhat; Jian Liu; Liangqin Guo; Doreen E Cashen; William J Martin; David Weinberg; Tanya MacNeil; Rui Tang; Constantin Tamvakopoulos; Qianping Peng; Randy R Miller; Ralph A Stearns; Howard Y Chen; Airu S Chen; Alison M Strack; Tung M Fong; D Euan MacIntyre; Matthew J Wyvratt; Ravi P Nargund
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.
Bioorganic & medicinal chemistry letters 2011;21(8):2330-4.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Ronsar Eid; Michael H Fisher; William H Parsons; Matthew J Wyvratt; Kathryn A Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; Ann Weber; Joseph L Duffy
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
Bioorganic & medicinal chemistry letters 2010;20(24):7479-82.
2010: Shuwen He; Zhixiong Ye; Peter H Dobbelaar; Raman K Bakshi; Qingmei Hong; James P Dellureficio; Iyassu K Sebhat; Liangqin Guo; Jian Liu; Tianying Jian; Yingjie Lai; Christopher L Franklin; Mikhail Reibarkh; Mark A Holmes; David Weinberg; Tanya MacNeil; Rui Tang; Constantin Tamvakopoulos; Qianping Peng; Randy R Miller; Ralph A Stearns; Howard Y Chen; Airu S Chen; Alison M Strack; Tung M Fong; Matthew J Wyvratt; Ravi P Nargund
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
Bioorganic & medicinal chemistry letters 2010;20(22):6524-32.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
Bioorganic & medicinal chemistry letters 2010;20(18):5536-40.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl pyrazoles as sodium channel blockers.
Bioorganic & medicinal chemistry letters 2010;20(18):5480-3.
2010: Liangqin Guo; Zhixiong Ye; Jian Liu; Shuwen He; Raman K Bakshi; Iyassu K Sebhat; Peter H Dobbelaar; Qingmei Hong; Tianying Jian; James P Dellureficio; Nancy N Tsou; Richard G Ball; David Weinberg; Tanya MacNeil; Rui Tang; Constantin Tamvakopoulos; Qianping Peng; Howard Y Chen; Airu S Chen; William J Martin; D Euan MacIntyre; Alison M Strack; Tung M Fong; Matthew J Wyvratt; Ravi P Nargund
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Bioorganic & medicinal chemistry letters 2010;20(16):4895-900.
2010: Shuwen He; Zhixiong Ye; Peter H Dobbelaar; Iyassu K Sebhat; Liangqin Guo; Jian Liu; Tianying Jian; Yingjie Lai; Christopher L Franklin; Raman K Bakshi; James P Dellureficio; Qingmei Hong; David Weinberg; Tanya MacNeil; Rui Tang; Alison M Strack; Constantin Tamvakopoulos; Qianping Peng; Randy R Miller; Ralph A Stearns; Howard Y Chen; Airu S Chen; Tung M Fong; Matthew J Wyvratt; Ravi P Nargund
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
Bioorganic & medicinal chemistry letters 2010;20(15):4399-405.
2010: Jian Liu; Shuwen He; Tianying Jian; Peter H Dobbelaar; Iyassu K Sebhat; Linus S Lin; Allan Goodman; Cheng Guo; Peter R Guzzo; Mark Hadden; Alan J Henderson; Kevin Pattamana; Megan Ruenz; Bruce J Sargent; Brian Swenson; Larry Yet; Constantin Tamvakopoulos; Qianping Peng; Jie Pan; Yanqing Kan; Oksana C Palyha; Theresa M Kelly; Xiao-Ming Guan; Andrew D Howard; Donald J Marsh; Joseph M Metzger; Marc L Reitman; Matthew J Wyvratt; Ravi P Nargund
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Bioorganic & medicinal chemistry letters 2010;20(7):2074-7.
2010: Shuwen He; Zhixiong Ye; Peter H Dobbelaar; Iyassu K Sebhat; Liangqin Guo; Jian Liu; Tianying Jian; Yingjie Lai; Christopher L Franklin; Raman K Bakshi; James P Dellureficio; Qingmei Hong; Nancy N Tsou; Richard G Ball; Doreen E Cashen; William J Martin; David Weinberg; Tanya MacNeil; Rui Tang; Constantin Tamvakopoulos; Qianping Peng; Randy R Miller; Ralph A Stearns; Howard Y Chen; Airu S Chen; Alison M Strack; Tung M Fong; D Euan MacIntyre; Matthew J Wyvratt; Ravi P Nargund
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.
Bioorganic & medicinal chemistry letters 2010;20(7):2106-10.
2009: Peter T Meinke; Steven L Colletti; Michael H Fisher; Matthew J Wyvratt; Thomas L Shih; Michelle B Ayer; Chunshi Li; J Lim; Dong Ok; Steve Salva; Lynn M Warmke; Michelle Zakson; BF Michael; Pierre Demontigny; DA Ostlind; David Fink; Marlene Drag; Dennis M Schmatz; Wesley L Shoop
Discovery of the development candidate N-tert-butyl nodulisporamide: a safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals.
Journal of medicinal chemistry 2009;52(11):3505-15.
2008: Liangqin Guo; Zhixiong Ye; Feroze Ujjainwalla; Heather L Sings; Iyassu K Sebhat; John Huber; David Weinberg; Rui Tang; Tanya MacNeil; Constantin Tamvakopoulos; Qianping Peng; Euan MacIntyre; Lex H T Van Der Ploeg; Mark T Goulet; Matthew J Wyvratt; Ravi P Nargund
Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.
Bioorganic & medicinal chemistry letters 2008;18(11):3242-7.
2008: Andrew Scribner; Richard Dennis; Shuliang Lee; Gilles Ouvry; David Perrey; Michael Fisher; Matthew J Wyvratt; Penny Leavitt; Paul A Liberator; Anne Gurnett; Chris Brown; John Mathew; Donald Thompson; Dennis M Schmatz; Szalkowski Deborah
Synthesis and biological activity of imidazopyridine anticoccidial agents: Part II.
European journal of medicinal chemistry 2008;43(6):1123-51.
2008: Scott B Hoyt; Clare London; Matthew J Wyvratt; Michael H Fisher; Doreen E Cashen; John P Felix; Maria L Garcia; Xiaohua Li; Kathryn A Lyons; D Euan MacIntyre; William J Martin; Birgit T Priest; McHardy Smith; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity.
Bioorganic & medicinal chemistry letters 2008;18(6):1963-6.
2008: Gui-Bai Liang; Xiaoxia Qian; Dennis Feng; Michael Fisher; Tami Crumley; Sandra J Darkin-Rattray; Paula M Dulski; Anne Gurnett; Penny Sue Leavitt; Paul A Liberator; Andrew S Misura; Samantha Tucker-Samaras; Tamas Tamas; Dennis M Schmatz; Matthew J Wyvratt; Szalkowski Deborah
N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents.
Bioorganic & medicinal chemistry letters 2008;18(6):2019-22.
2008: Dooseop Kim; Jennifer E Kowalchick; Linda L Brockunier; Emma R Parmee; George J Eiermann; Michael H Fisher; Huaibing He; Barbara Leiting; Kathryn Lyons; Giovanna Scapin; Sangita B Patel; Aleksandr Petrov; KellyAnn D Pryor; Ranabir Sinha Roy; Joseph K Wu; Xiaoping Zhang; Matthew J Wyvratt; Bei B Zhang; Lan Zhu; Nancy A Thornberry; Ann E Weber
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.
Journal of medicinal chemistry 2008;51(3):589-602.
2007: Andrew Scribner; Richard Dennis; Jean Hong; Shuliang Lee; Donald McIntyre; David Perrey; Dennis Feng; Michael Fisher; Matthew J Wyvratt; Penny Leavitt; Paul A Liberator; Anne Gurnett; Chris Brown; John Mathew; Donald Thompson; Dennis M Schmatz; Szalkowski Deborah
Synthesis and biological activity of imidazopyridine anticoccidial agents: part I.
European journal of medicinal chemistry 2007;42(11-12):1334-57.
2007: Scott B Hoyt; Clare London; David J. Gorin; Matthew J Wyvratt; Michael H Fisher; Catherine Abbadie; John P Felix; Maria L Garcia; Xiaohua Li; Kathryn A Lyons; Erin McGowan; D Euan MacIntyre; William J Martin; Birgit T Priest; Amy Ritter; McHardy Smith; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain.
Bioorganic & medicinal chemistry letters 2007;17(16):4630-4.
2007: Gui-Bai Liang; Xiaoxia Qian; Dennis Feng; Michael Fisher; Christine M Brown; Anne Gurnett; Penny Sue Leavitt; Paul A Liberator; Andrew S Misura; Tamas Tamas; Dennis M Schmatz; Matthew J Wyvratt; Szalkowski Deborah
Synthesis and SAR studies of potent imidazopyridine anticoccidial agents.
Bioorganic & medicinal chemistry letters 2007;17(13):3558-61.
2006: Dennis Feng; Michael Fisher; Gui-Bai Liang; Xiaoxia Qian; Chris Brown; Anne Gurnett; Penny Sue Leavitt; Paul A Liberator; John Mathew; Andrew S Misura; Samantha Tucker-Samaras; Tamas Tamas; Dennis M Schmatz; Matthew J Wyvratt; Szalkowski Deborah
Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents.
Bioorganic & medicinal chemistry letters 2006;16(23):5978-81.
2006: Xiaoxia Qian; Gui-Bai Liang; Dennis Feng; Michael Fisher; Tami Crumley; Sandra Rattray; Paula M Dulski; Anne Gurnett; Penny Sue Leavitt; Paul A Liberator; Andrew S Misura; Samantha Tucker-Samaras; Tamas Tamas; Dennis M Schmatz; Matthew J Wyvratt; Szalkowski Deborah
Synthesis and SAR studies of diarylpyrrole anticoccidial agents.
Bioorganic & medicinal chemistry letters 2006;16(10):2817-21.
2006: Szalkowski Deborah; Dennis Feng; Michael Fisher; Gui-Bai Liang; Xiaoxia Qian; Andrew Scribner; Richard Dennis; Shuliang Lee; Paul A Liberator; Chris Brown; Anne Gurnett; Penny Sue Leavitt; Donald Thompson; John Mathew; Andrew S Misura; Samantha Tucker-Samaras; Tamas Tamas; Joseph F Sina; Kathleen A McNulty; Crystal G McKnight; Dennis M Schmatz; Matthew J Wyvratt
Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents.
Bioorganic & medicinal chemistry letters 2006;16(9):2479-83.
2006: Dong Ok; Chunshi Li; Catherine Abbadie; John P Felix; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Kathryn A Lyons; William J Martin; Birgit T Priest; McHardy Smith; Brande S Williams; Matthew J Wyvratt; William H Parsons
Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers.
Bioorganic & medicinal chemistry letters 2006;16(5):1358-61.
2005: Gui-Bai Liang; Xiaoxia Qian; Szalkowski Deborah; Dennis Feng; Michael Fisher; Tami Crumley; Sandra J Darkin-Rattray; Paula M Dulski; Anne Gurnett; Penny Sue Leavitt; Paul A Liberator; Andrew S Misura; Samantha Tucker-Samaras; Tamas Tamas; Dennis M Schmatz; Matthew J Wyvratt
Hydroxylated N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives as potent broad-spectrum anticoccidial agents.
Bioorganic & medicinal chemistry letters 2005;15(20):4570-3.
2005: Zhixiong Ye; Tanya MacNeil; David Weinberg; Rubana N Kalyani; Rui Tang; Alison M Strack; Beth A Murphy; Ralph T Mosley; D Euan MacIntyre; Lex H T Van Der Ploeg; Arthur A Patchett; Matthew J Wyvratt; Ravi P Nargund
Structure-activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat.
Peptides 2005;26(10):2017-25.
2005: Feroze Ujjainwalla; Daniel Warner; Christine Snedden; Ricky D Grisson; Thomas F Walsh; Matthew J Wyvratt; Rubana N Kalyani; Tanya MacNeil; Rui Tang; David Weinberg; Lex H T Van Der Ploeg; Mark T Goulet
Design and syntheses of melanocortin subtype-4 receptor agonists. Part 2: discovery of the dihydropyridazinone motif.
Bioorganic & medicinal chemistry letters 2005;15(18):4023-8.
2005: Zhixiong Ye; Liangqin Guo; Khaled Barakat; Patrick G Pollard; Brenda L Palucki; Iyassu K Sebhat; Raman K Bakshi; Rui Tang; Rubana N Kalyani; Aurawan Vongs; Airu S Chen; Howard Y Chen; Charles I Rosenblum; Tanya MacNeil; David Weinberg; Qianping Peng; Constantin Tamvakopoulos; Randall R Miller; Ralph A Stearns; Doreen E Cashen; William J Martin; Joseph M Metzger; Alison M Strack; D Euan MacIntyre; Lex H T Van Der Ploeg; Arthur A Patchett; Matthew J Wyvratt; Ravi P Nargund
Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist.
Bioorganic & medicinal chemistry letters 2005;15(15):3501-5.
2005: Szalkowski Deborah; Dennis Feng; Mitree Ponpipom; Narindar Girotra; Gui-Bai Liang; Xiaoxia Qian; Robert Bugianesi; Joseph Simeone; Linda Chang; Anne Gurnett; Paul A Liberator; Paula M Dulski; Penny Sue Leavitt; Tami Crumley; Andrew S Misura; Terence Murphy; Sandra Rattray; Samantha Tucker-Samaras; Tamas Tamas; John Mathew; Christine Brown; Don Thompson; Dennis M Schmatz; Michael Fisher; Matthew J Wyvratt
Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
Bioorganic & medicinal chemistry letters 2005;15(13):3296-301.
2005: Pengcheng P Shao; Dong Ok; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Chunshi Li; Kathryn A Lyons; William J Martin; Peter T Meinke; Birgit T Priest; McHardy Smith; Matthew J Wyvratt; Feng Ye; William H Parsons
Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.
Bioorganic & medicinal chemistry letters 2005;15(7):1901-7.
2005: Dooseop Kim; Liping Wang; Maria G Beconi; George J Eiermann; Michael H Fisher; Huaibing He; Gerard J Hickey; Jennifer E Kowalchick; Barbara Leiting; Kathryn Lyons; Frank Marsilio; Margaret E McCann; Reshma A Patel; Aleksandr Petrov; Giovanna Scapin; Sangita B Patel; Ranabir Sinha Roy; Joseph K Wu; Matthew J Wyvratt; Bei B Zhang; Lan Zhu; Nancy A Thornberry; Ann E Weber
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal of medicinal chemistry 2005;48(1):141-51.
2004: Robert J DeVita; Mamta Parikh; Jinlong Jiang; Jason A Fair; Jonathan R Young; Thomas F Walsh; Mark T Goulet; Jane-L Lo; Ning Ren; Joel B Yudkovitz; Jisong Cui; Yi Tien Yang; Kang Cheng; Susan P Rohrer; Matthew J Wyvratt
Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2004;14(22):5599-603.
2004: Jinlong Jiang; Robert J DeVita; Mark T Goulet; Matthew J Wyvratt; Jane-L Lo; Ning Ren; Joel B Yudkovitz; Jisong Cui; Yi Tien Yang; Kang Cheng; Susan P Rohrer
Syntheses and structure-activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists.
Bioorganic & medicinal chemistry letters 2004;14(7):1795-8.
2003: Feroze Ujjainwalla; Daniel Warner; Thomas F Walsh; Matthew J Wyvratt; Changyou Zhou; Lihu Yang; Rubana N Kalyani; Tanya MacNeil; Lex H T Van Der Ploeg; Charles I Rosenblum; Rui Tang; Aurawan Vongs; David Weinberg; Mark T Goulet
Design and syntheses of melanocortin subtype-4 receptor agonists: evolution of the pyridazinone archetype.
Bioorganic & medicinal chemistry letters 2003;13(24):4431-5.
2003: Scott D Edmondson; Anthony Mastracchio; Jiafang He; Christine C Chung; Michael J Forrest; Scott Hofsess; Euan MacIntyre; Joseph Metzger; Naphtali O'Connor; Kajal Patel; Xinchun Tong; Michael R Tota; Lex H T Van Der Ploeg; Jeffrey P Varnerin; Michael H Fisher; Matthew J Wyvratt; Ann E Weber; Emma R Parmee
Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(22):3983-7.
2003: Prasun K Chakravarty; Thomas L Shih; Steven L Colletti; Michelle B Ayer; Christine Snedden; Howard Kuo; Sriram Tyagarajan; Lynn Gregory; Michelle Zakson-Aiken; Wesley L Shoop; Dennis M Schmatz; Matthew J Wyvratt; Michael H Fisher; Peter T Meinke
Nodulisporic acid side-chain modifications: access to the 2", 3", 4", and 6" registers.
Bioorganic & medicinal chemistry letters 2003;13(1):147-50.
2002: Dong Ok; Chunshi Li; Thomas L Shih; Steve Salva; Michelle B Ayer; Steven L Colletti; Prasun K Chakravarty; Matthew J Wyvratt; Michael H Fisher; Lynn Gregory; Michelle Zakson-Aiken; Wesley L Shoop; Dennis M Schmatz; Peter T Meinke
Side-chain homologation of nodulisporic acid: synthesis of potent new dienyl derivatives.
Bioorganic & medicinal chemistry letters 2002;12(13):1751-4.
2002: Prasun K Chakravarty; Sriram Tyagarajan; Thomas L Shih; Steve Salva; Christine Snedden; Matthew J Wyvratt; Michael H Fisher; Peter T Meinke
Synthesis of side chain truncated 3"-aldehyde, 3"-carboxylic acid, and 1"-aldehyde from nodulisporic acid A.
Organic letters 2002;4(8):1291-4.
2002: Jonathan R Young; Song X Huang; Thomas F Walsh; Matthew J Wyvratt; Yi Tien Yang; Joel B Yudkovitz; Jisong Cui; George R Mount; Rena Ning Ren; Tsuei-Ju Wu; Xiaolan Shen; Kathryn A Lyons; Ann Mao; Josephine R Carlin; Bindhu V Karanam; Stella H Vincent; Kang Cheng; Mark T Goulet
2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: optimization of the tryptamine side chain.
Bioorganic & medicinal chemistry letters 2002;12(5):827-32.
2001: R Berger; Wesley L Shoop; James V Pivnichny; L M Warmke; Michelle Zakson-Aiken; K A Owens; P deMontigny; Dennis M Schmatz; Matthew J Wyvratt; Michael H Fisher; Peter T Meinke; Steven L Colletti
Synthesis of nodulisporic acid 2' '-oxazoles and 2' '-thiazoles.
Organic letters 2001;3(23):3715-8.
2001: Wesley L Shoop; Michelle Zakson-Aiken; Lynn Gregory; BF Michael; James V Pivnichny; Peter T Meinke; Michael H Fisher; Matthew J Wyvratt; B Pikounis; Dennis M Schmatz
Systemic efficacy of nodulisporamides against fleas on dogs.
The Journal of parasitology 2001;87(5):1150-4.
2001: Peter Lin; Mamta Parikh; Jane-L Lo; Yi Tien Yang; Kang Cheng; Roy G Smith; Michael H Fisher; Matthew J Wyvratt; Mark T Goulet
Heterocyclic derivatives of 2-(3,5-dimethylphenyl)tryptamine as GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2001;11(8):1077-80.
2001: Peter Lin; D Marino; Jane-L Lo; Yi Tien Yang; Kang Cheng; Roy G Smith; Michael H Fisher; Matthew J Wyvratt; Mark T Goulet
2-(3,5-Dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor.
Bioorganic & medicinal chemistry letters 2001;11(8):1073-6.
2001: Gary J Hom; Michael J Forrest; TJ Bach; Edward J Brady; Mari Rios Candelore; Margaret A Cascieri; D J Fletcher; Michael H Fisher; Susan A Iliff; Robert J Mathvink; J Metzger; V Pecore; Richard Saperstein; T Shih; Ann E Weber; Matthew J Wyvratt; P Zafian; D Euan MacIntyre
Beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, facial flushing, and reflex tachycardia in anesthetized rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 2001;297(1):299-307.
2001: Robert J DeVita; Thomas F Walsh; Jonathan R Young; Jinlong Jiang; Feroze Ujjainwalla; Richard B Toupence; Mamta Parikh; Song X Huang; J A Fair; Mark T Goulet; Matthew J Wyvratt; Jane-L Lo; Ning Ren; Joel B Yudkovitz; Yi Tien Yang; Kang Cheng; Jisong Cui; George R Mount; Susan P Rohrer; James M Schaeffer; L Rhodes; Jennifer E Drisko; Erin McGowan; D Euan MacIntyre; S Vincent; Josephine R Carlin; J Cameron; Roy G Smith
A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor.
Journal of medicinal chemistry 2001;44(6):917-22.
2001: L Chu; Jane-L Lo; Yi Tien Yang; Kang Cheng; Roy G Smith; Michael H Fisher; Matthew J Wyvratt; Mark T Goulet
SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2001;11(4):515-7.
2001: L Chu; JE Hutchins; Ann E Weber; Jane-L Lo; Yi Tien Yang; Kang Cheng; Roy G Smith; Michael H Fisher; Matthew J Wyvratt; Mark T Goulet
Initial structure-activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles.
Bioorganic & medicinal chemistry letters 2001;11(4):509-13.
2001: Linda L Brockunier; Mari Rios Candelore; Margaret A Cascieri; Y Liu; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber; Emma R Parmee
Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties.
Bioorganic & medicinal chemistry letters 2001;11(3):379-82.
2001: Steven L Colletti; RW Myers; Sandra J Darkin-Rattray; Anne Gurnett; Paula M Dulski; S Galuska; John Allocco; Michelle B Ayer; Chunshi Li; J Lim; Tami Crumley; C Cannova; Dennis M Schmatz; Matthew J Wyvratt; Michael H Fisher; Peter T Meinke
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.
Bioorganic & medicinal chemistry letters 2001;11(2):113-7.
2001: Steven L Colletti; RW Myers; Sandra J Darkin-Rattray; Anne Gurnett; Paula M Dulski; S Galuska; John Allocco; Michelle B Ayer; Chunshi Li; J Lim; Tami Crumley; C Cannova; Dennis M Schmatz; Matthew J Wyvratt; Michael H Fisher; Peter T Meinke
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.
Bioorganic & medicinal chemistry letters 2001;11(2):107-11.
2000: Peter T Meinke; Steven L Colletti; G Doss; RW Myers; Anne Gurnett; Paula M Dulski; Sandra J Darkin-Rattray; John Allocco; S Galuska; Dennis M Schmatz; Matthew J Wyvratt; Michael H Fisher
Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.
Journal of medicinal chemistry 2000;43(25):4919-22.
2000: Michael J Forrest; Gary J Hom; TJ Bach; Mari Rios Candelore; Margaret A Cascieri; Catherine D Strader; Laurie M Tota; Michael H Fisher; J Szumiloski; Hyun O Ok; Ann E Weber; Matthew J Wyvratt; Pasquale P Vicario; O Marko; L Deng; C Cioffe; B Hegarty-Friscino; E MacIntyre
L-750355, a human beta3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey.
European journal of pharmacology 2000;407(1-2):175-81.
2000: Robert J Mathvink; J S Tolman; Dawn Chitty; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Randall R Miller; Ralph A Stearns; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide.
Journal of medicinal chemistry 2000;43(21):3832-6.
2000: Peter T Meinke; Michelle B Ayer; Steven L Colletti; Chunshi Li; J Lim; Dong Ok; Steve Salva; Dennis M Schmatz; Thomas L Shih; Wesley L Shoop; L M Warmke; Matthew J Wyvratt; Michelle Zakson-Aiken; Michael H Fisher
Chemical modification of nodulisporic acid A: preliminary structure-activity relationships.
Bioorganic & medicinal chemistry letters 2000;10(20):2371-4.
2000: Emma R Parmee; Linda L Brockunier; Jiafang He; Sheo B Singh; Mari Rios Candelore; Margaret A Cascieri; L Deng; Y Liu; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists.
Bioorganic & medicinal chemistry letters 2000;10(20):2283-6.
2000: Linda L Brockunier; Emma R Parmee; Hyun O Ok; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Human beta3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides.
Bioorganic & medicinal chemistry letters 2000;10(18):2111-4.
2000: Robert J Mathvink; J S Tolman; Dawn Chitty; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore.
Bioorganic & medicinal chemistry letters 2000;10(17):1971-3.
2000: Jonathan R Young; Song X Huang; I Chen; Thomas F Walsh; Robert J DeVita; Matthew J Wyvratt; Mark T Goulet; Ning Ren; J Lo; Yi Tien Yang; Joel B Yudkovitz; Kang Cheng; Roy G Smith
Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents.
Bioorganic & medicinal chemistry letters 2000;10(15):1723-7.
2000: Hyun O Ok; L B Reigle; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Catherine D Strader; Laurie M Tota; P Wang; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Substituted oxazole benzenesulfonamides as potent human beta3 adrenergic receptor agonists.
Bioorganic & medicinal chemistry letters 2000;10(14):1531-4.
2000: Szalkowski Deborah; D D Feng; Gui-Bai Liang; H Kuo; Xiaoxia Qian; Elizabeth M Naylor; Vincent J Colandrea; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Ralph A Stearns; Catherine D Strader; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents.
Bioorganic & medicinal chemistry letters 2000;10(13):1431-4.
2000: D D Feng; Szalkowski Deborah; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Randall R Miller; Ralph A Stearns; Catherine D Strader; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Discovery of an orally bioavailable alkyl oxadiazole beta3 adrenergic receptor agonist.
Bioorganic & medicinal chemistry letters 2000;10(13):1427-9.
2000: Thomas F Walsh; Richard B Toupence; Jonathan R Young; Song X Huang; Feroze Ujjainwalla; Robert J DeVita; Mark T Goulet; Matthew J Wyvratt; Michael H Fisher; Jane-L Lo; Ning Ren; Joel B Yudkovitz; Yi Tien Yang; Kang Cheng; Roy G Smith
Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides.
Bioorganic & medicinal chemistry letters 2000;10(5):443-7.
1999: Peter Lin; J M Pisano; W R Schoen; Kang Cheng; Wanda W-S Chan; Bridget Butler; Roy G Smith; Michael H Fisher; Matthew J Wyvratt
Acyclic structural variants of growth hormone secretagogue L-692,429.
Bioorganic & medicinal chemistry letters 1999;9(22):3237-42.
1999: Robert J DeVita; Mark T Goulet; Matthew J Wyvratt; Michael H Fisher; Jane-L Lo; Yi Tien Yang; Kang Cheng; Roy G Smith
Investigation of the 4-O-alkylamine substituent of non-peptide quinolone GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 1999;9(17):2621-4.
1999: Robert J DeVita; D D Hollings; Mark T Goulet; Matthew J Wyvratt; Michael H Fisher; Jane-L Lo; Yi Tien Yang; Kang Cheng; Roy G Smith
Identification and initial structure-activity relationships of a novel non-peptide quinolone GnRH receptor antagonist.
Bioorganic & medicinal chemistry letters 1999;9(17):2615-20.
1999: H M Armstrong; Frederick Wong; M A Holmes; Peter J Sinclair; Mark T Goulet; Francis J Dumont; Mary Jo Staruch; Sam L Koprak; Laurence B Peterson; R Rosa; MB Wilusz; GJ Wiederrecht; JG Cryan; Matthew J Wyvratt; William H Parsons
Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.
Bioorganic & medicinal chemistry letters 1999;9(14):2089-94.
1999: Mark T Goulet; Peter J Sinclair; Frederick Wong; Mary Jo Staruch; Francis J Dumont; JG Cryan; GJ Wiederrecht; Matthew J Wyvratt; William H Parsons
C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study.
Bioorganic & medicinal chemistry letters 1999;9(14):2085-8.
1999: Robert J Mathvink; A M Barritta; Mari Rios Candelore; Margaret A Cascieri; L Deng; Laurie M Tota; Catherine D Strader; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Potent, elective human beta3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore.
Bioorganic & medicinal chemistry letters 1999;9(13):1869-74.
1999: Thomas L Shih; Mari Rios Candelore; Margaret A Cascieri; Shuet-Hing Lee Chiu; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Randall R Miller; Ralph A Stearns; Catherine D Strader; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability.
Bioorganic & medicinal chemistry letters 1999;9(9):1251-4.
1999: Elizabeth M Naylor; Emma R Parmee; Vincent J Colandrea; L Perkins; Linda L Brockunier; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Catherine D Strader; Laurie M Tota; Pei-ran Wang; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Human beta3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides.
Bioorganic & medicinal chemistry letters 1999;9(5):755-8.
1999: Emma R Parmee; Elizabeth M Naylor; L Perkins; Vincent J Colandrea; Hyun O Ok; Mari Rios Candelore; Margaret A Cascieri; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Randall R Miller; Ralph A Stearns; Catherine D Strader; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Human beta3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides.
Bioorganic & medicinal chemistry letters 1999;9(5):749-54.
1998: Elizabeth M Naylor; Vincent J Colandrea; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Catherine D Strader; Laurie M Tota; Pei-ran Wang; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists.
Bioorganic & medicinal chemistry letters 1998;8(21):3087-92.
1998: Mark T Goulet; S R McAlpine; Mary Jo Staruch; Sam L Koprak; Francis J Dumont; JG Cryan; GJ Wiederrecht; R Rosa; MB Wilusz; Laurence B Peterson; Matthew J Wyvratt; William H Parsons
C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential.
Bioorganic & medicinal chemistry letters 1998;8(16):2253-8.
1998: Robert J DeVita; R Bochis; A J Frontier; Andrew Kotliar; Michael H Fisher; W R Schoen; Matthew J Wyvratt; Kang Cheng; Wanda W-S Chan; Bridget Butler; Thomas M Jacks; Gerard J Hickey; Klaus D Schleim; K Leung; Zhongguo Chen; S L Chiu; William P Feeney; Paul K Cunningham; Roy G Smith
A potent, orally bioavailable benzazepinone growth hormone secretagogue.
Journal of medicinal chemistry 1998;41(10):1716-28.
1998: Emma R Parmee; Hyun O Ok; Mari Rios Candelore; Laurie M Tota; L Deng; Catherine D Strader; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist.
Bioorganic & medicinal chemistry letters 1998;8(9):1107-12.
1998: Ann E Weber; Robert J Mathvink; L Perkins; JE Hutchins; Mari Rios Candelore; Laurie M Tota; Catherine D Strader; Matthew J Wyvratt; Michael H Fisher
Potent, selective benzenesulfonamide agonists of the human beta 3 adrenergic receptor.
Bioorganic & medicinal chemistry letters 1998;8(9):1101-6.
1998: F J Dumont; Sam L Koprak; Mary Jo Staruch; A Talento; Gloria C Koo; C DaSilva; Peter J Sinclair; Frederick Wong; J Woods; J Barker; James V Pivnichny; I Singer; NH Sigal; A R Williamson; William H Parsons; Matthew J Wyvratt
A tacrolimus-related immunosuppressant with reduced toxicity.
Transplantation 1998;65(1):18-26.
1998: Laurence B Peterson; JG Cryan; R Rosa; M M Martin; MB Wilusz; Peter J Sinclair; Frederick Wong; J N Parsons; S J O'Keefe; William H Parsons; Matthew J Wyvratt; NH Sigal; A R Williamson; GJ Wiederrecht
A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus.
Transplantation 1998;65(1):10-8.
1998: Arthur A Patchett; Roy G Smith; Matthew J Wyvratt
Orally active growth hormone secretagogues.
Pharmaceutical biotechnology 1998;11():525-54.
1997: Roy G Smith; Lex H T Van Der Ploeg; Andrew D Howard; Scott Feighner; Kang Cheng; Gerard J Hickey; Matthew J Wyvratt; Michael H Fisher; Ravi P Nargund; Arthur A Patchett
Peptidomimetic regulation of growth hormone secretion.
Endocrine reviews 1997;18(5):621-45.
1994: W R Schoen; J M Pisano; Kris Prendergast; Matthew J Wyvratt; Michael H Fisher; Kang Cheng; Wanda W-S Chan; Bridget Butler; Roy G Smith; R G Ball
A novel 3-substituted benzazepinone growth hormone secretagogue (L-692,429).
Journal of medicinal chemistry 1994;37(7):897-906.
1993: William H Parsons; Nolan Sigal; Matthew J Wyvratt
FK-506--a novel immunosuppressant.
Annals of the New York Academy of Sciences 1993;685():22-36.
1993: Kang Cheng; Wanda W-S Chan; Bridget Butler; L Wei; W R Schoen; Matthew J Wyvratt; Michael H Fisher; Roy G Smith
Stimulation of growth hormone release from rat primary pituitary cells by L-692,429, a novel non-peptidyl GH secretagogue.
Endocrinology 1993;132(6):2729-31.
1992: Francis J Dumont; Mary Jo Staruch; Sam L Koprak; John Siekierka; C S Lin; R Harrison; T Sewell; V M Kindt; T R Beattie; Matthew J Wyvratt
The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.
The Journal of experimental medicine 1992;176(3):751-60.
1991: J C Chabala; VB Waits; T Ikeler; Arthur A Patchett; L Payne; L H Peterson; R A Reamer; K Hoogsteen; Matthew J Wyvratt; WL Hanson
1-(substituted)benzyl-5-aminoimidazole-4-carboxamides are potent orally active inhibitors of Trypanosoma cruzi in mice.
Experientia 1991;47(1):51-3.
1988: Matthew J Wyvratt
Evolution of angiotensin-converting enzyme inhibitors.
Clinical physiology and biochemistry 1988;6(3-4):217-29.
1985: Matthew J Wyvratt; Arthur A Patchett
Recent developments in the design of angiotensin-converting enzyme inhibitors.
Medicinal research reviews 1985;5(4):483-531.
1980: A A Patchett; E Harris; E W Tristram; Matthew J Wyvratt; M T Wu; D Taub; E R Peterson; T J Ikeler; J ten Broeke; L G Payne; D L Ondeyka; E D Thorsett; W J Greenlee; N S Lohr; R D Hoffsommer; H Joshua; W V Ruyle; J W Rothrock; S D Aster; A L Maycock; F M Robinson; R Hirschmann; C S Sweet; E H Ulm; D M Gross; T C Vassil; C A Stone
A new class of angiotensin-converting enzyme inhibitors.
Nature 1980;288(5788):280-3.