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Yan Xia

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Weiwei Yang; M James You; Lin Zhang; Yanhua Zheng; Inder M Verma; Yan Xia; Kenneth Aldape; Wen Bu; Yu Cao; Paul J Chiao; Gilbert Cote; Mei Yee Koh; Yi Li; Zhimin Lu
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Weiwei Yang; Yanhua Zheng; Costas A Lyssiotis; Yan Xia; Kenneth Aldape; Lewis C Cantley; Xiaomin Chen; Fang Guo; Haitao Ji; Zhimin Lu
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Weiwei Yang; Yan Xia; Dongming Xing; Kenneth Aldape; W K Alfred Yung; David Hawke; Tony Hunter; Xinjian Li; Ji Liang; Zhimin Lu
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.

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All Publications

2012: Weiwei Yang; M James You; Lin Zhang; Yanhua Zheng; Inder M Verma; Yan Xia; Kenneth Aldape; Wen Bu; Yu Cao; Paul J Chiao; Gilbert Cote; Mei Yee Koh; Yi Li; Zhimin Lu
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Molecular cell 2012;48(5):771-84.
2012: Weiwei Yang; Yanhua Zheng; Costas A Lyssiotis; Yan Xia; Kenneth Aldape; Lewis C Cantley; Xiaomin Chen; Fang Guo; Haitao Ji; Zhimin Lu
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Nature cell biology 2012;14(12):1295-304.
2012: Weiwei Yang; Yan Xia; Dongming Xing; Kenneth Aldape; W K Alfred Yung; David Hawke; Tony Hunter; Xinjian Li; Ji Liang; Zhimin Lu
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.
Cell 2012;150(4):685-96.
2011: Weiwei Yang; Yanhua Zheng; Yan Xia; Kenneth Aldape; Xiang Gao; Wenhua Huang; Haitao Ji; Ji Liang; Zhimin Lu
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.
Nature 2011;480(7375):118-22.
2011: Yanhua Zheng; David Hawke; David X Liu; Yan Xia; Weiwei Yang; Zhimin Lu
Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST.
Molecular and cellular biology 2011;31(21):4258-69.
2009: Yanhua Zheng; Yan Xia; David Hawke; Maxime Halle; Michel L Tremblay; Xiang Gao; Xiao Zhen Zhou; Kenneth Aldape; Melanie H Cobb; Keping Xie; Jie He; Zhimin Lu
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
Molecular cell 2009;35(1):11-25.
2009: Hehua Chen; Yan Xia; Dexing Fang; David Hawke; Zhimin Lu
Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis.
Molecular and cellular biology 2009;29(13):3657-64.
2007: Dexing Fang; David Hawke; Yanhua Zheng; Yan Xia; Jill Meisenhelder; Heinz Nika; Gordon B Mills; Ryuji Kobayashi; Tony Hunter; Zhimin Lu
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.
The Journal of biological chemistry 2007;282(15):11221-9.
2007: Yan Xia; Ji Wang; Ta-Jen Liu; W K Alfred Yung; Tony Hunter; Zhimin Lu
c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis.
Molecular cell 2007;25(2):219-32.
2007: Yan Xia; Ji Wang; Shuichan Xu; Gary L Johnson; Tony Hunter; Zhimin Lu
MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress.
Molecular and cellular biology 2007;27(2):510-7.
2000: Jinke Cheng; Jianhua Yang; Yan Xia; Michael Karin; Bing Su
Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.
Molecular and cellular biology 2000;20(7):2334-42.

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