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Maria Bretner

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Laszlo Gyenis; Agnieszka Kuś; Maria Bretner; David W Litchfield
Functional proteomics strategy for validation of protein kinase inhibitors reveals new targets for a TBB-derived inhibitor of protein kinase CK2.
Laszlo Gyenis; Maria Bretner; James S Duncan; Jacob P Turowec; David W Litchfield
Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2.
Małgorzata Makowska; Patrycja Wińska; Edyta Łukowska-Chojnacka; Aleksandra Bilińska-Chomik; Agnieszka Kuś; Maria Bretner
Design and synthesis of CK2 inhibitors.

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All Publications

2013: Laszlo Gyenis; Agnieszka Kuś; Maria Bretner; David W Litchfield
Functional proteomics strategy for validation of protein kinase inhibitors reveals new targets for a TBB-derived inhibitor of protein kinase CK2.
Journal of proteomics 2013;81():70-9.
2011: Laszlo Gyenis; Maria Bretner; James S Duncan; Jacob P Turowec; David W Litchfield
Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2.
Journal of proteome research 2011;10(11):4887-901.
2011: Małgorzata Makowska; Patrycja Wińska; Edyta Łukowska-Chojnacka; Aleksandra Bilińska-Chomik; Agnieszka Kuś; Maria Bretner
Design and synthesis of CK2 inhibitors.
Molecular and cellular biochemistry 2011;356(1-2):91-6.
2011: Nils Bischoff; Maria Bretner; Olaf-Georg Issinger; Birgitte Olsen; Jennifer Raaf; Karsten Niefind
Enzymatic activity with an incomplete catalytic spine: insights from a comparative structural analysis of human CK2α and its paralogous isoform CK2α'.
Molecular and cellular biochemistry 2011;356(1-2):57-65.
2011: Damian Graczyk; Janusz Debski; Grazyna Muszyńska; Maria Bretner; Olivier Lefebvre; Magdalena Boguta
Casein kinase II-mediated phosphorylation of general repressor Maf1 triggers RNA polymerase III activation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(12):4926-31.
2011: Nils Bischoff; Birgitte Olsen; Jennifer Raaf; Maria Bretner; Olaf-Georg Issinger; Karsten Niefind
Structure of the human protein kinase CK2 catalytic subunit CK2α' and interaction thermodynamics with the regulatory subunit CK2β.
Journal of molecular biology 2011;407(1):1-12.
2010: Andzelika Najda-Bernatowicz; Mariusz Krawczyk; Anna Stankiewicz-Drogoń; Maria Bretner; Anna M Boguszewska-Chachulska
Studies on the anti-hepatitis C virus activity of newly synthesized tropolone derivatives: identification of NS3 helicase inhibitors that specifically inhibit subgenomic HCV replication.
Bioorganic & medicinal chemistry 2010;18(14):5129-36.
2009: Bozena Kaminska; Aleksandra Ellert-Miklaszewska; Agata Oberbek; Pawel Wisniewski; Beata Kaza; Malgorzata Makowska; Maria Bretner; Zygmunt Kazimierczuk
Efficacy and mechanism of anti-tumor action of new potential CK2 inhibitors toward glioblastoma cells.
International journal of oncology 2009;35(5):1091-100.
2009: Andzelika Najda-Bernatowicz; Maja Łebska; Andrzej Orzeszko; Katarzyna Kopańska; Ewa Krzywińska; Grazyna Muszyńska; Maria Bretner
Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2.
Bioorganic & medicinal chemistry 2009;17(4):1573-8.
2008: Maria Bretner; Andzelika Najda-Bernatowicz; Maja Łebska; Grazyna Muszyńska; Anna Kilanowicz; Andrzej Sapota
New inhibitors of protein kinase CK2, analogues of benzimidazole and benzotriazole.
Molecular and cellular biochemistry 2008;316(1-2):87-9.
2008: James S Duncan; Laszlo Gyenis; John Lenehan; Maria Bretner; Lee M Graves; Timothy A Haystead; David W Litchfield
An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets.
Molecular & cellular proteomics : MCP 2008;7(6):1077-88.
2007: Jarosław Poznański; Andzelika Najda; Maria Bretner; David Shugar
Experimental (13C NMR) and theoretical (ab initio molecular orbital calculations) studies on the prototropic tautomerism of benzotriazole and some derivatives symmetrically substituted on the benzene ring.
The journal of physical chemistry. A 2007;111(28):6501-9.
2006: Ganna Panasyuk; Ivan Nemazanyy; Alexander Zhyvoloup; Maria Bretner; David W Litchfield; Valeriy Filonenko; Ivan T Gout
Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser-17.
The Journal of biological chemistry 2006;281(42):31188-201.
2006: Anna M Boguszewska-Chachulska; Mariusz Krawczyk; Andzelika Najda; Katarzyna Kopańska; Anna Stankiewicz-Drogoń; Wlodzimierz Zagórski-Ostoja; Maria Bretner
Searching for a new anti-HCV therapy: synthesis and properties of tropolone derivatives.
Biochemical and biophysical research communications 2006;341(2):641-7.
2005: Piotr Zien; James S Duncan; Janusz S Skierski; Maria Bretner; David W Litchfield; David Shugar
Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.
Biochimica et biophysica acta 2005;1754(1-2):271-80.
2005: Katarzyna Domanska-Vannieuwenhuyse; Rafał Zieliński; Konrad Kubiński; Ewa Sajnaga; Maciej Masłyk; Maria Bretner; Ryszard Szyszka
Different properties of four molecular forms of protein kinase CK2 from Saccharomyces cerevisiae.
Acta biochimica Polonica 2005;52(4):947-51.
2005: Maria Bretner; Andrea Baier; Katarzyna Kopańska; Andzelika Najda; Anna Schoof; Michael Reinholz; Andrzej Lipniacki; Andrzej Piasek; Tadeusz Kulikowski; Peter Borowski
Synthesis and biological activity of 1H-benzotriazole and 1H-benzimidazole analogues--inhibitors of the NTpase/helicase of HCV and of some related Flaviviridae.
Antiviral chemistry & chemotherapy 2005;16(5):315-26.
2005: Maria Bretner
Existing and future therapeutic options for hepatitis C virus infection.
Acta biochimica Polonica 2005;52(1):57-70.
2004: Maria Bretner; Andzelika Najda; Romualda Podwińska; Andrea Baier; Katarzyna Paruch; Andrzej Lipniacki; Andrzej Piasek; Peter Borowski; Tadeusz Kulikowski
Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses.
Acta poloniae pharmaceutica 2004;61 Suppl():26-8.
2004: Katarzyna Kopańska; Andzelika Najda; Justyna Zebrowska; Lidia Chomicz; Janusz Piekarczyk; Przemyslaw Myjak; Maria Bretner
Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii.
Bioorganic & medicinal chemistry 2004;12(10):2617-24.
2004: Maria Bretner; Sarah Schalinski; Annemarie Haag; Melanie Lang; Herbert Schmitz; Andrea Baier; Sven-E Behrens; Tadeusz Kulikowski; Peter Borowski
Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses.
Antiviral chemistry & chemotherapy 2004;15(1):35-42.
2003: Piotr Zień; Olga Abramczyk; Katarzyna Domanska-Vannieuwenhuyse; Maria Bretner; Ryszard Szyszka
TBBz but not TBBt discriminates between two molecular forms of CK2 in vivo and its implications.
Biochemical and biophysical research communications 2003;312(3):623-8.
2003: Ning Zhang; Huan-Ming Chen; Verena Koch; Herbert Schmitz; Ching-Len Liao; Maria Bretner; Vishweshwar S Bhadti; Ali I Fattom; Robert B Naso; Ramachandra S Hosmane; Peter Borowski
Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus.
Journal of medicinal chemistry 2003;46(19):4149-64.
2003: Piotr Zień; Maria Bretner; Katarzyna Zastapiło; Ryszard Szyszka; David Shugar
Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources.
Biochemical and biophysical research communications 2003;306(1):129-33.
2003: Maria Bretner; Sarah Schalinski; Peter Borowski; Tadeusz Kulikowski
5'-O-fluorosulfonylbenzoyl esters of purine nucleosides as potential inhibitors of NTPase/helicase and polymerase of Flaviviridae viruses.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1531-3.
2003: A Miazga; Krzysztof Felczak; Maria Bretner; Maria A Siwecka; Andrzej Piasek; Tadeusz Kulikowski
Thiated analogues of 2',3'-dideoxy-3'-fluorothymidine and their phosphorylated and phosphonylated derivatives: synthesis, interaction with HIV reverse transcriptase, and in vitro anti-HIV activity.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):973-5.
2003: Jarek Poznanski; Maria Bretner; Tadeusz Kulikowski; Jan Balzarini; Arthur Van Aerschot; Erik De Clercq
Synthesis, solution conformation and anti-HIV activity of novel 3'-substituted-2',3'-dideoxy-5-hydroxymethyluridines and their 4,5-substituted analogues.
Antiviral chemistry & chemotherapy 2003;14(3):127-38.
2003: Peter Borowski; Johanna Deinert; Sarah Schalinski; Maria Bretner; Krzysztof Ginalski; Tadeusz Kulikowski; David Shugar
Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses.
European journal of biochemistry / FEBS 2003;270(8):1645-53.
2002: Peter Borowski; Andreas Niebuhr; Herbert Schmitz; Ramachandra S Hosmane; Maria Bretner; Maria A Siwecka; Tadeusz Kulikowski
NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme.
Acta biochimica Polonica 2002;49(3):597-614.
2001: J Poznański; Krzysztof Felczak; Maria Bretner; Tadeusz Kulikowski; M Remin
1H NMR conformational study of a variety of alpha-anomers of C5-substituted 2'-deoxyuridines: comparison to their antiherpetic beta counterparts.
Biochemical and biophysical research communications 2001;283(5):1142-9.
2001: J K Gill; L Wang; Maria Bretner; R Newman; Natasha Kyprianou; Ramachandra S Hosmane
Potent in vitro anticancer activities of ring-expanded ("fat") nucleosides containing the imidazo[4,5-e][1,3]diazepine ring system.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1043-5.
2001: Peter Borowski; Andreas Niebuhr; O Mueller; Maria Bretner; Krzysztof Felczak; Tadeusz Kulikowski; Herbert Schmitz
Purification and characterization of West Nile virus nucleoside triphosphatase (NTPase)/helicase: evidence for dissociation of the NTPase and helicase activities of the enzyme.
Journal of virology 2001;75(7):3220-9.
2000: Krzysztof Felczak; A Miazga; J Poznański; Maria Bretner; Tadeusz Kulikowski; Jolanta M Dzik; B Gołos; Z Zieliński; J Cieśla; Wojciech Rode
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Journal of medicinal chemistry 2000;43(24):4647-56.
1999: Maria Bretner; T D Beckett; Ramesh Sood; D M Baldisseri; Ramachandra S Hosmane
Substrate/inhibition studies of bacteriophage T7 RNA polymerase with the 5'-triphosphate derivative of a ring-expanded ('fat') nucleoside possessing potent antiviral and anticancer activities.
Bioorganic & medicinal chemistry 1999;7(12):2931-6.
1999: Maria Bretner; Dorothy Beckett; Ramachandra S Hosmane
Potent anti-hepatitis B viral activity and inhibition of bacteriophage T7 RNA polymerase by a "fat" nucleoside and its 5'-triphosphate derivative: synthetic, biochemical, and biological studies of 4,8-diamino-6-imino-6H-1-beta-D-ribofuranosyl-imidazo[4,5-E] [1,3]diazepine-5'-triphosphate.
Nucleosides & nucleotides 1999;18(4-5):837-8.
1998: A Jarmuła; R Anulewicz; A Leś; M K Cyrański; Ludwik Adamowicz; Maria Bretner; Krzysztof Felczak; Tadeusz Kulikowski; Tadeusz M Krygowski; Wojciech Rode
Crystal structures of 5-fluoro-dUrd and its 2 and/or 4-thio analogues: models of substituted dUMP pyrimidine ring interacting with thymidylate synthase.
Biochimica et biophysica acta 1998;1382(2):277-86.
1998: Krzysztof Felczak; B Gołos; Jolanta M Dzik; Wojciech Rode; Maria Bretner; David Shugar; Tadeusz Kulikowski
Acyclic analogues of 5-fluoro-dUMP and 5-fluoro-2'-deoxyuridine: synthesis and inhibition of thymidylate synthase and tumour cell growth.
Acta biochimica Polonica 1998;45(1):75-82.
1998: Krzysztof Felczak; Maria Bretner; Jolanta M Dzik; B Gołos; Z Zieliński; Wojciech Rode; Tadeusz Kulikowski
N4-hydroxy-5-halogeno-2'-deoxycytidine S and their 5'-mono-phosphates as inhibitors of thymidylate synthase and in vitro antileukemic agents.
Advances in experimental medicine and biology 1998;431():617-21.
1996: Jolanta M Dzik; Maria Bretner; Tadeusz Kulikowski; B Gołos; A Jarmuła; J Poznański; Wojciech Rode; David Shugar
Synthesis and interactions with thymidylate synthase of 2,4-dithio analogues of dUMP and 5-fluoro-dUMP.
Biochimica et biophysica acta 1996;1293(1):1-8.
1995: J Cieśla; B Gołos; Jolanta M Dzik; K Pawełczak; M Kempny; M Makowski; Maria Bretner; Tadeusz Kulikowski; B Machnicka; B Rzeszotarska
Thymidylate synthases from Hymenolepis diminuta and regenerating rat liver: purification, properties, and inhibition by substrate and cofactor analogues.
Biochimica et biophysica acta 1995;1249(2):127-36.
1993: Maria Bretner; Tadeusz Kulikowski; Jolanta M Dzik; M Balińska; Wojciech Rode; David Shugar
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Journal of medicinal chemistry 1993;36(23):3611-7.
1993: Jolanta M Dzik; Z Zieliński; J Cieśla; Maria Bretner; Tadeusz Kulikowski; David Shugar; J R Bertino; Wojciech Rode
Interaction of 2-thio-5-fluoro-dUMP and 4-thio-5-fluoro-dUMP with mammalian normal and tumour and helminthic thymidylate synthases: influence of C(4)-substituents on specificity for enzyme inactivation.
Biochemical and biophysical research communications 1993;195(3):1301-8.
1993: H Rostkowska; M J Nowak; L Lapinski; Maria Bretner; Tadeusz Kulikowski; A Leś; Ludwik Adamowicz
Theoretical and matrix-isolation experimental studies on 2-thiocytosine and 5-fluoro-2-thiocytosine.
Biochimica et biophysica acta 1993;1172(3):239-46.
1993: Jolanta M Dzik; Z Zieliński; J Cieśla; Wojciech Rode; Maria Bretner; Tadeusz Kulikowski; David Shugar
Interaction with 2(4)-thio-5-fluoro-dUMP of thymidylate synthases with differing sensitivities to 5-fluoro-dUMP.
Advances in experimental medicine and biology 1993;338():617-20.
1990: Wojciech Rode; Z Zieliński; Jolanta M Dzik; Tadeusz Kulikowski; Maria Bretner; B Kierdaszuk; J Cieśla; David Shugar
Mechanism of inhibition of mammalian tumor and other thymidylate synthases by N4-hydroxy-dCMP, N4-hydroxy-5-fluoro-dCMP, and related analogues.
Biochemistry 1990;29(48):10835-42.
1988: Jolanta M Dzik; Maria Bretner; Tadeusz Kulikowski; J Ciesla; J M Ciesla; Wojciech Rode; David Shugar
Interaction of the 5'-phosphates of the anti-HIV agents, 3'-azido-3'-deoxythymidine and 3'-azido-2',3'-dideoxyuridine, with thymidylate synthase.
Biochemical and biophysical research communications 1988;155(3):1418-23.
1987: Tadeusz Kulikowski; Maria Bretner; Jolanta M Dzik; Z Zieliński; J Cieśla; Wojciech Rode; J A Vilpo; David Shugar
Synthesis and antimetabolic properties of 4,5-substituted pyrimidine 2'-deoxynucleosides and their 5'-monophosphates.
Nucleic acids symposium series 1987;(18):61-4.