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Rui-Ping Xiao

Research Profile

Chemicals & Drugs

Anatomy

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Rats
Mouse

Physiology

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Myocardial Contraction

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Ruisheng Song; Hong-Kun Wu; Mao Zhang; Xin Zhang; Xiuqin Zhang; Yan Zhang; Chun-Mei Cao; Yongxing Cao; Jiaojiao Guo; Ping Jiang; Peng Jiang; Li Jin; Fenghua Liu; Fengxiang Lv; Shaoshuai Meng; Wei Peng; Yanbin Pi; Rui-Ping Xiao
Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders.
Yan Zhang; Ting Zhang; Chun-Mei Cao; Rui-Ping Xiao
mTOR: good, bad, or ugly?
Weizhong Zhu; Aizhi Zhao; Khalid Chakir; J Kurt Chuprun; Gerald W Dorn; Arthur M Feldman; Erhe Gao; Walter J Koch; Edward G Lakatta; Natalia Petrashevskaya; Shuxun Ren; Mark Talan; Yibin Wang; Rui-Ping Xiao
Gi-biased β2AR signaling links GRK2 upregulation to heart failure.

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All Publications

2013: Ruisheng Song; Hong-Kun Wu; Mao Zhang; Xin Zhang; Xiuqin Zhang; Yan Zhang; Chun-Mei Cao; Yongxing Cao; Jiaojiao Guo; Ping Jiang; Peng Jiang; Li Jin; Fenghua Liu; Fengxiang Lv; Shaoshuai Meng; Wei Peng; Yanbin Pi; Rui-Ping Xiao
Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders.
Nature 2013;494(7437):375-9.
2012: Yan Zhang; Ting Zhang; Chun-Mei Cao; Rui-Ping Xiao
mTOR: good, bad, or ugly?
Cardiovascular research 2012;95(3):261-2.
2012: Weizhong Zhu; Aizhi Zhao; Khalid Chakir; J Kurt Chuprun; Gerald W Dorn; Arthur M Feldman; Erhe Gao; Walter J Koch; Edward G Lakatta; Natalia Petrashevskaya; Shuxun Ren; Mark Talan; Yibin Wang; Rui-Ping Xiao
Gi-biased β2AR signaling links GRK2 upregulation to heart failure.
Circulation research 2012;110(2):265-74.
2011: Mark I Talan; Rui-Ping Xiao; Ismayil Ahmet; Edward G Lakatta
β₂ AR agonists in treatment of chronic heart failure: long path to translation.
Journal of molecular and cellular cardiology 2011;51(4):529-33.
2011: Khalid Chakir; Charlene Depry; Veronica L Dimaano; Nickolai Dulin; Theodore P Abraham; Jozef Bartunek; Shu-bai Liu; Eiki Takimoto; Gordon F Tomaselli; Marc Vanderheyden; Yang K Xiang; Rui-Ping Xiao; Jin Zhang; Manling Zhang; Wei-Zhong Zhu; David A Kass
Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart.
Science translational medicine 2011;3(100):100ra88.
2011: Yan Zhang; Chun-Mei Cao; Li Jin; Fengxiang Lv; Jianjie Ma; Wei Peng; Ruisheng Song; Rui-Ping Xiao
MG53 participates in ischaemic postconditioning through the RISK signalling pathway.
Cardiovascular research 2011;91(1):108-15.
2011: Khalid Chakir; Weizhong Zhu; Sharon Tsang; Anthony Yiu-Ho Woo; Dongmei Yang; Xianhua Wang; Xiaokun Zeng; Man-Hee Rhee; Ulrike Mende; Norimichi Koitabashi; Eiki Takimoto; Kendall J Blumer; Edward G Lakatta; David A Kass; Rui-Ping Xiao
RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.
Journal of molecular and cellular cardiology 2011;50(6):1000-7.
2011: Zhongcui Sun; Jifeng Zhang; Ji Zhang; Chunlei Chen; Quan Du; Lin Chang; Chunmei Cao; Ming Zheng; Minerva Garcia-Barrio; Chen Lab; Rui-Ping Xiao; Jieming Mao; Xiaojun Zhu
Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase.
Biochemical and biophysical research communications 2011;409(1):52-7.
2011: Krzysztof Jozwiak; Anita Plazinska; Lawrence Toll; Anthony Woo; Rui-Ping Xiao; Lucita Jimenez; irving william wainer
Effect of fenoterol stereochemistry on the β2 adrenergic receptor system: ligand-directed chiral recognition.
Chirality 2011;23 Suppl 1():E1-6.
2010: Ming Zheng; Rui-Ping Xiao
Role of mitofusin 2 in cardiovascular oxidative injury.
Journal of molecular medicine (Berlin, Germany) 2010;88(10):987-91.
2010: Xianhua Wang; Wenjun Xie; Yi Zhang; Peihui Lin; Liang Han; Peidong Han; Yanru Wang; Zheng Chen; Guangju Ji; Ming Zheng; Noah Weisleder; Rui-Ping Xiao; Hiroshi Takeshima; Jianjie Ma; Heping Cheng
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair.
Circulation research 2010;107(1):76-83.
2010: Chun-Mei Cao; Yan Zhang; Noah Weisleder; Christopher Ferrante; Xianhua Wang; Fengxiang Lv; Yi Zhang; Ruisheng Song; Moonsun Hwang; Li Jin; Jiaojiao Guo; Wei Peng; Geng Li; Miyuki Nishi; Hiroshi Takeshima; Jianjie Ma; Rui-Ping Xiao
MG53 constitutes a primary determinant of cardiac ischemic preconditioning.
Circulation 2010;121(23):2565-74.
2010: Krzysztof Jozwiak; Lawrence Toll; Lucita Jimenez; Anthony Yiu-Ho Woo; Rui-Ping Xiao; irving william wainer
The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptor.
Biochemical pharmacology 2010;79(11):1610-5.
2010: Qian Li; Geng Li; Xiaomei Lan; Ming Zheng; Kuang-Hueih Chen; Chun-Mei Cao; Rui-Ping Xiao
Receptor interacting protein 3 suppresses vascular smooth muscle cell growth by inhibition of the phosphoinositide 3-kinase-Akt axis.
The Journal of biological chemistry 2010;285(13):9535-44.
2010: Krzysztof Jozwiak; Anthony Woo; Mary J Tanga; Lawrence Toll; Lucita Jimenez; Joseph A Kozocas; Anita Plazinska; Rui-Ping Xiao; irving william wainer
Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists.
Bioorganic & medicinal chemistry 2010;18(2):728-36.
2010: Wei Peng; Yan Zhang; Ming Zheng; Heping Cheng; Weizhong Zhu; Chun-Mei Cao; Rui-Ping Xiao
Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70.
Circulation research 2010;106(1):102-10.
2010: Sharon Tsang; Anthony Woo; Weizhong Zhu; Rui-Ping Xiao
Deregulation of RGS2 in cardiovascular diseases.
Frontiers in bioscience (Scholar edition) 2010;2():547-57.
2008: Ismayil Ahmet; Melissa Krawczyk; Weizhong Zhu; Anthony Woo; Christopher Morrell; Suresh Poosala; Rui-Ping Xiao; Edward G Lakatta; Mark I Talan
Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction.
The Journal of pharmacology and experimental therapeutics 2008;325(2):491-9.
2008: Dali Luo; Dongmei Yang; Xiaomei Lan; Kaitao Li; Xiaodong Li; Ju Chen; Youyi Zhang; Rui-Ping Xiao; Qide Han; Heping Cheng
Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes.
Cell calcium 2008;43(2):165-74.
2007: Xiaomei Guo; Kuang-Hueih Chen; Yanhong Guo; Hua Liao; Jian Tang; Rui-Ping Xiao
Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway.
Circulation research 2007;101(11):1113-22.
2007: Tao Shen; Ming Zheng; Chunmei Cao; Chunlei Chen; Jian Tang; Wanrui Zhang; Heping Cheng; Kuang-Hueih Chen; Rui-Ping Xiao
Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis.
The Journal of biological chemistry 2007;282(32):23354-61.
2007: Krzysztof Jozwiak; Chakir Khalid; Mary J Tanga; Ilona Berzetei-Gurske; Lucita Jimenez; Joseph A Kozocas; Anthony Woo; Weizhong Zhu; Rui-Ping Xiao; Darrell R. Abernethy; irving william wainer
Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.
Journal of medicinal chemistry 2007;50(12):2903-15.
2007: Weizhong Zhu; Anthony Woo; Dongmei Yang; Heping Cheng; Michael T Crow; Rui-Ping Xiao
Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis.
The Journal of biological chemistry 2007;282(14):10833-9.
2007: Dongmei Yang; Wei-Zhong Zhu; Bailong Xiao; Didier Brochet; S R Wayne Chen; Edward G Lakatta; Rui-Ping Xiao; Heping Cheng
Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes.
Circulation research 2007;100(3):399-407.
2006: Yingbo Yang; Wei-Zhong Zhu; Mei-ling Joiner; Rong Zhang; Carmine V Oddis; Yue Hou; Jinying Yang; Edward E Price; Linda A Gleaves; Mesut Eren; Gemin Ni; Douglas E Vaughan; Rui-Ping Xiao; Mark E Anderson
Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo.
American journal of physiology. Heart and circulatory physiology 2006;291(6):H3065-75.
2006: Farideh Beigi; Carlo Bertucci; Weizhong Zhu; Khalid Chakir; irving william wainer; Rui-Ping Xiao; Darrell R. Abernethy
Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol.
Chirality 2006;18(10):822-7.
2006: Da-li Luo; Jian Gao; Xiao-mei Lan; Gang Wang; Sheng Wei; Rui-Ping Xiao; Qi-De Han
Role of inositol 1,4,5-trisphosphate receptors in alpha1-adrenergic receptor-induced cardiomyocyte hypertrophy.
Acta pharmacologica Sinica 2006;27(7):895-900.
2006: Rui-Ping Xiao; Weizhong Zhu; Ming Zheng; Chunmei Cao; Youyi Zhang; Edward G Lakatta; Qide Han
Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart.
Trends in pharmacological sciences 2006;27(6):330-7.
2006: Tatiana M Vinogradova; Alexey E Lyashkov; Weizhong Zhu; Abdul M Ruknudin; Syevda G Sirenko; Dongmei Yang; Shekhar Deo; Matthew Barlow; Shavsha Johnson; James L Caffrey; Ying-Ying Zhou; Rui-Ping Xiao; Heping Cheng; Michael D Stern; Victor A Maltsev; Edward G Lakatta
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells.
Circulation research 2006;98(4):505-14.
2005: Ming Zheng; Weizhong Zhu; Qide Han; Rui-Ping Xiao
Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
Pharmacology & therapeutics 2005;108(3):257-68.
2005: Wei-Zhong Zhu; Khalid Chakir; Shengjun Zhang; Dongmei Yang; Catherine Lavoie; Michel Bouvier; Terence E Hébert; Edward G Lakatta; Heping Cheng; Rui-Ping Xiao
Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility.
Circulation research 2005;97(3):244-51.
2005: Dali Luo; Hongli Sun; Rui-Ping Xiao; Qide Han
Caffeine induced Ca2+ release and capacitative Ca2+ entry in human embryonic kidney (HEK293) cells.
European journal of pharmacology 2005;509(2-3):109-15.
2005: Ming Zheng; Cherilynn Reynolds; Su-Hyun Jo; Robert P Wersto; Qide Han; Rui-Ping Xiao
Intracellular acidosis-activated p38 MAPK signaling and its essential role in cardiomyocyte hypoxic injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):109-11.
2004: Farideh Beigi; Khalid Chakir; Rui-Ping Xiao; irving william wainer
G-protein-coupled receptor chromatographic stationary phases. 2. Ligand-induced conformational mobility in an immobilized beta2-adrenergic receptor.
Analytical chemistry 2004;76(24):7187-93.
2004: Veronique Leblais; Su-Hyun Jo; Khalid Chakir; Victor A Maltsev; Ming Zheng; Michael T Crow; Wang Wang; Edward G Lakatta; Rui-Ping Xiao
Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.
Circulation research 2004;95(12):1183-90.
2004: Wang Wang; Weizhong Zhu; Shiqiang Wang; Dongmei Yang; Michael T Crow; Rui-Ping Xiao; Heping Cheng
Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway.
Circulation research 2004;95(8):798-806.
2004: Ming Zheng; Rong Hou; Rui-Ping Xiao
Acidosis-induced p38 MAPK activation and its implication in regulation of cardiac contractility.
Acta pharmacologica Sinica 2004;25(10):1299-305.
2004: Kuang-Hueih Chen; Xiaomei Guo; Dalong Ma; Yanhong Guo; Qian Li; Dongmei Yang; Pengfei Li; Xiaoyan Qiu; Shaojun Wen; Rui-Ping Xiao; Jian Tang
Dysregulation of HSG triggers vascular proliferative disorders.
Nature cell biology 2004;6(9):872-83.
2004: Rui-Ping Xiao; Weizhong Zhu; Ming Zheng; Khalid Chakir; Richard Bond; Edward G Lakatta; Heping Cheng
Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications.
Trends in pharmacological sciences 2004;25(7):358-65.
2004: Ming Zheng; Rong Hou; Qide Han; Rui-Ping Xiao
Different regulation of ERK1/2 activation by beta-adrenergic receptor subtypes in adult mouse cardiomyocytes.
Heart, lung & circulation 2004;13(2):179-83.
2004: Ming Zheng; Qi-De Han; Rui-Ping Xiao
Distinct beta-adrenergic receptor subtype signaling in the heart and their pathophysiological relevance.
Sheng li xue bao : [Acta physiologica Sinica] 2004;56(1):1-15.
2004: Guoxiang Chu; Gregory F Egnaczyk; Wen Zhao; Su-Hyun Jo; Guo-Chang Fan; John E Maggio; Rui-Ping Xiao; Evangelia G Kranias
Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20.
Circulation research 2004;94(2):184-93.
2004: Rui-Ping Xiao; C William Balke
Na+/Ca2+ exchange linking beta2-adrenergic G(i) signaling to heart failure: associated defect of adrenergic contractile support.
Journal of molecular and cellular cardiology 2004;36(1):7-11.
2003: Khalid Chakir; Yang Xiang; Dongmei Yang; Sheng-Jun Zhang; Heping Cheng; Brian K Kobilka; Rui-Ping Xiao
The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor.
Molecular pharmacology 2003;64(5):1048-58.
2003: Rui-Ping Xiao; Sheng-Jun Zhang; Khalid Chakir; Pavel Avdonin; Weizhong Zhu; Richard A Bond; C William Balke; Edward G Lakatta; Heping Cheng
Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts.
Circulation 2003;108(13):1633-9.
2003: Dongmei Yang; Long-Sheng Song; Wei-Zhong Zhu; Khalid Chakir; Wei Wang; Caihong Wu; Yibin Wang; Rui-Ping Xiao; S R Wayne Chen; Heping Cheng
Calmodulin regulation of excitation-contraction coupling in cardiac myocytes.
Circulation research 2003;92(6):659-67.
2003: Norihito Sasaki; Mitsushige Murata; Yiru Guo; Su-Hyun Jo; Andreas Ohler; Masaharu Akao; Brian O'Rourke; Rui-Ping Xiao; Roberto Bolli; Eduardo Marban
MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning.
Circulation 2003;107(8):1183-8.
2003: Wei-Zhong Zhu; Shi-Qiang Wang; Khalid Chakir; Dongmei Yang; Tong Zhang; Joan Heller Brown; Eric Devic; Brian K Kobilka; Heping Cheng; Rui-Ping Xiao
Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.
The Journal of clinical investigation 2003;111(5):617-25.
2002: Catherine Lavoie; Jean-François Mercier; Ali Salahpour; Dhiviya Umapathy; Andreas Breit; Louis Villeneuve; Wei-Zhong Zhu; Rui-Ping Xiao; Edward G Lakatta; Michel Bouvier; Terence E Hébert
Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy.
The Journal of biological chemistry 2002;277(38):35402-10.
2002: Su-Hyun Jo; Veronique Leblais; Ping H Wang; Michael T Crow; Rui-Ping Xiao
Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation.
Circulation research 2002;91(1):46-53.
2002: Long-Sheng Song; Antonio Guia; James N Muth; Marta Rubio; Shi-Qiang Wang; Rui-Ping Xiao; Ira R Josephson; Edward G Lakatta; Arnold Schwartz; Heping Cheng
Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel.
Circulation research 2002;90(2):174-81.
2002: Dirk Hagemann; Rui-Ping Xiao
Dual site phospholamban phosphorylation and its physiological relevance in the heart.
Trends in cardiovascular medicine 2002;12(2):51-6.
2001: Rui-Ping Xiao
Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
Science's STKE : signal transduction knowledge environment 2001;2001(104):re15.
2001: Long-Sheng Song; Shi-Qiang Wang; Rui-Ping Xiao; Harold A Spurgeon; Edward G Lakatta; Heping Cheng
beta-Adrenergic stimulation synchronizes intracellular Ca(2+) release during excitation-contraction coupling in cardiac myocytes.
Circulation research 2001;88(8):794-801.
2001: Wei-Zhong Zhu; Ming Zheng; Walter J Koch; RJ Lefkowitz; Brian K Kobilka; Rui-Ping Xiao
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1607-12.
2000: Ming Zheng; Sheng-Jun Zhang; Wei-Zhong Zhu; Bruce D Ziman; Brian K Kobilka; Rui-Ping Xiao
beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes.
The Journal of biological chemistry 2000;275(51):40635-40.
2000: Alan Chesley; MS Lundberg; T Asai; Rui-Ping Xiao; S Ohtani; Edward G Lakatta; Michael T Crow
The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase.
Circulation research 2000;87(12):1172-9.
2000: Ye Chen-Izu; Rui-Ping Xiao; Leighton Izu; Heping Cheng; Meike Kuschel; Harold A Spurgeon; Edward G Lakatta
G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels.
Biophysical journal 2000;79(5):2547-56.
2000: Ying-Ying Zhou; Dongmei Yang; Wei-Zhong Zhu; Sheng-Jun Zhang; D J Wang; Daniel K Rohrer; E Devic; Brian K Kobilka; Edward G Lakatta; Heping Cheng; Rui-Ping Xiao
Spontaneous activation of beta(2)- but not beta(1)-adrenoceptors expressed in cardiac myocytes from beta(1)beta(2) double knockout mice.
Molecular pharmacology 2000;58(5):887-94.
2000: Tatiana M Vinogradova; Ying-Ying Zhou; Konstantin Y Bogdanov; Dongmei Yang; Meike Kuschel; Heping Cheng; Rui-Ping Xiao
Sinoatrial node pacemaker activity requires Ca(2+)/calmodulin-dependent protein kinase II activation.
Circulation research 2000;87(9):760-7.
2000: Dirk Hagemann; Meike Kuschel; T Kuramochi; Weizhong Zhu; Heping Cheng; Rui-Ping Xiao
Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes.
The Journal of biological chemistry 2000;275(29):22532-6.
2000: Sheng-Jun Zhang; Heping Cheng; Ying-Ying Zhou; D J Wang; Weizhong Zhu; Bruce D Ziman; H Spurgoen; RJ Lefkowitz; Edward G Lakatta; Walter J Koch; Rui-Ping Xiao
Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
The Journal of biological chemistry 2000;275(28):21773-9.
2000: Ying-Ying Zhou; Shi-Qiang Wang; Wei-Zhong Zhu; AJ Chruscinski; Brian K Kobilka; Bruce D Ziman; Su Wang; Edward G Lakatta; Heping Cheng; Rui-Ping Xiao
Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H429-36.
1999: Ying-Ying Zhou; Long-Sheng Song; Edward G Lakatta; Rui-Ping Xiao; Heping Cheng
Constitutive beta2-adrenergic signalling enhances sarcoplasmic reticulum Ca2+ cycling to augment contraction in mouse heart.
The Journal of physiology 1999;521 Pt 2():351-61.
1999: Rui-Ping Xiao; Heping Cheng; Ying-Ying Zhou; Meike Kuschel; Edward G Lakatta
Recent advances in cardiac beta(2)-adrenergic signal transduction.
Circulation research 1999;85(11):1092-100.
1999: Ying-Ying Zhou; Heping Cheng; Long-Sheng Song; D Wang; Edward G Lakatta; Rui-Ping Xiao
Spontaneous beta(2)-adrenergic signaling fails to modulate L-type Ca(2+) current in mouse ventricular myocytes.
Molecular pharmacology 1999;56(3):485-93.
1999: Meike Kuschel; Ying-Ying Zhou; Heping Cheng; Sheng-Jun Zhang; Ye Chen-Izu; Edward G Lakatta; Rui-Ping Xiao
G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling.
The Journal of biological chemistry 1999;274(31):22048-52.
1999: Meike Kuschel; Ying-Ying Zhou; Harold A Spurgeon; Sabine Bartel; Peter Karczewski; Sheng-Jun Zhang; Ernst-Georg Krause; Edward G Lakatta; Rui-Ping Xiao
beta2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart.
Circulation 1999;99(18):2458-65.
1999: Rui-Ping Xiao; Pavel Avdonin; Ying-Ying Zhou; Heping Cheng; S A Akhter; T Eschenhagen; RJ Lefkowitz; Walter J Koch; Edward G Lakatta
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
Circulation research 1999;84(1):43-52.
1998: Ying-Ying Zhou; Edward G Lakatta; Rui-Ping Xiao
Age-associated alterations in calcium current and its modulation in cardiac myocytes.
Drugs & aging 1998;13(2):159-71.
1998: Rui-Ping Xiao; E D Tomhave; D J Wang; X Ji; Marvin O Boluyt; Heping Cheng; Edward G Lakatta; Walter J Koch
Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases.
The Journal of clinical investigation 1998;101(6):1273-82.
1997: Ying-Ying Zhou; Heping Cheng; Konstantin Y Bogdanov; C Hohl; Ruth A Altschuld; Edward G Lakatta; Rui-Ping Xiao
Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling.
The American journal of physiology 1997;273(3 Pt 2):H1611-8.
1997: Rui-Ping Xiao; Héctor H Valdivia; Konstantin Y Bogdanov; C Valdivia; Edward G Lakatta; Heping Cheng
The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart.
The Journal of physiology 1997;500 ( Pt 2)():343-54.
1997: Salvatore Pepe; Rui-Ping Xiao; C Hohl; Ruth A Altschuld; Edward G Lakatta
'Cross talk' between opioid peptide and adrenergic receptor signaling in isolated rat heart.
Circulation 1997;95(8):2122-9.
1997: Rui-Ping Xiao; Salvatore Pepe; Harold A Spurgeon; M C Capogrossi; Edward G Lakatta
Opioid peptide receptor stimulation reverses beta-adrenergic effects in rat heart cells.
The American journal of physiology 1997;272(2 Pt 2):H797-805.
1997: D H Korzick; Rui-Ping Xiao; Bruce D Ziman; Walter J Koch; RJ Lefkowitz; Edward G Lakatta
Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine.
The American journal of physiology 1997;272(1 Pt 2):H590-6.
1996: Heping Cheng; M R Lederer; Rui-Ping Xiao; Ana Gomez; Ying-Ying Zhou; Bruce D Ziman; Harold A Spurgeon; Edward G Lakatta; William Lederer
Excitation-contraction coupling in heart: new insights from Ca2+ sparks.
Cell calcium 1996;20(2):129-40.
1995: Rui-Ping Xiao; X Ji; Edward G Lakatta
Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes.
Molecular pharmacology 1995;47(2):322-9.
1994: Rui-Ping Xiao; Harold A Spurgeon; F O'Connor; Edward G Lakatta
Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling.
The Journal of clinical investigation 1994;94(5):2051-9.
1994: Rui-Ping Xiao; CM Hohl; Ruth A Altschuld; L Jones; B Livingston; Bruce D Ziman; B Tantini; Edward G Lakatta
Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation.
The Journal of biological chemistry 1994;269(29):19151-6.
1993: Rui-Ping Xiao; Edward G Lakatta
Beta 1-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2+, and Ca2+ current in single rat ventricular cells.
Circulation research 1993;73(2):286-300.
1993: Rui-Ping Xiao; Harold A Spurgeon; Maurizio C Capogrossi; Edward G Lakatta
Stimulation of opioid receptors on cardiac ventricular myocytes reduces L type Ca2+ channel current.
Journal of molecular and cellular cardiology 1993;25(6):661-6.
1992: Rui-Ping Xiao; Edward G Lakatta
Deterioration of beta-adrenergic modulation of cardiovascular function with aging.
Annals of the New York Academy of Sciences 1992;673():293-310.
1992: M Sakai; Robert S Danziger; Rui-Ping Xiao; Harold A Spurgeon; Edward G Lakatta
Contractile response of individual cardiac myocytes to norepinephrine declines with senescence.
The American journal of physiology 1992;262(1 Pt 2):H184-9.