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Xiaodong Xiao

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Weizao Chen; Xiaodong Xiao; Yanping Wang; Zhongyu Zhu; Dimiter S Dimitrov
Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates.
Kristin Loomis; Brandon Smith; Yang Feng; Himanshu Garg; Amichai Yavlovich; Ryan Campbell-Massa; Dimiter S Dimitrov; Robert Blumenthal; Xiaodong Xiao; Anu Puri
Specific targeting to B cells by lipid-based nanoparticles conjugated with a novel CD22-ScFv.
Xiaodong Xiao; Zhongyu Zhu; Jennifer L Dankmeyer; Michael M Wormald; Randy L Fast; Patricia L Worsham; Christopher K Cote; Kei Amemiya; Dimiter S Dimitrov
Human anti-plague monoclonal antibodies protect mice from Yersinia pestis in a bubonic plague model.

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All Publications

2010: Weizao Chen; Xiaodong Xiao; Yanping Wang; Zhongyu Zhu; Dimiter S Dimitrov
Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates.
Antiviral research 2010;88(1):107-15.
2010: Kristin Loomis; Brandon Smith; Yang Feng; Himanshu Garg; Amichai Yavlovich; Ryan Campbell-Massa; Dimiter S Dimitrov; Robert Blumenthal; Xiaodong Xiao; Anu Puri
Specific targeting to B cells by lipid-based nanoparticles conjugated with a novel CD22-ScFv.
Experimental and molecular pathology 2010;88(2):238-49.
2010: Xiaodong Xiao; Zhongyu Zhu; Jennifer L Dankmeyer; Michael M Wormald; Randy L Fast; Patricia L Worsham; Christopher K Cote; Kei Amemiya; Dimiter S Dimitrov
Human anti-plague monoclonal antibodies protect mice from Yersinia pestis in a bubonic plague model.
PloS one 2010;5(10):e13047.
2009: Xiaodong Xiao; Weizao Chen; Yang Feng; Zhongyu Zhu; Prabakaran Ponraj; Yanping Wang; Mei-Yun Zhang; Nancy S Longo; Dimiter S Dimitrov
Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens.
Biochemical and biophysical research communications 2009;390(3):404-9.
2009: Xiaodong Xiao; Yang Feng; Weizao Chen; Dimiter S Dimitrov
Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies.
Viruses 2009;1(3):802-17.
2009: Xiaodong Xiao; Yang Feng; Bang K Vu; Rieko Ishima; Dimiter S Dimitrov
A large library based on a novel (CH2) scaffold: identification of HIV-1 inhibitors.
Biochemical and biophysical research communications 2009;387(2):387-92.
2009: Xiaodong Xiao; Mitchell Ho; Zhongyu Zhu; Ira Pastan; Dimiter S Dimitrov
Identification and characterization of fully human anti-CD22 monoclonal antibodies.
mAbs 2009;1(3):297-303.
2009: Yang Feng; Xiaodong Xiao; Zhongyu Zhu; Emily Streaker; Mitchell Ho; Ira Pastan; Dimiter S Dimitrov
A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity.
Molecular cancer therapeutics 2009;8(5):1113-8.
2009: Prabakaran Ponraj; Zhongyu Zhu; Xiaodong Xiao; Arya Biragyn; Antony S Dimitrov; Christopher C Broder; Dimiter S Dimitrov
Potent human monoclonal antibodies against SARS CoV, Nipah and Hendra viruses.
Expert opinion on biological therapy 2009;9(3):355-68.
2009: Weizao Chen; Zhongyu Zhu; Xiaodong Xiao; Dimiter S Dimitrov
Construction of a human antibody domain (VH) library.
Methods in molecular biology (Clifton, N.J.) 2009;525():81-99, xiii.
2008: Weizao Chen; Zhongyu Zhu; Yang Feng; Xiaodong Xiao; Dimiter S Dimitrov
Construction of a large phage-displayed human antibody domain library with a scaffold based on a newly identified highly soluble, stable heavy chain variable domain.
Journal of molecular biology 2008;382(3):779-89.
2007: Zhongyu Zhu; Samitabh Chakraborti; Yuxian He; Anjeanette Roberts; Timothy Sheahan; Xiaodong Xiao; Lisa E Hensley; Prabakaran Ponraj; Barry Rockx; Igor Sidorov; Davide Corti; Leatrice Vogel; Yang Feng; Jae-Ouk Kim; Lin-Fa Wang; Ralph S Baric; Antonio Lanzavecchia; Kris Curtis; Gary Nabel; Kanta Subbarao; Shibo Jiang; Dimiter S Dimitrov
Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12123-8.
2006: Prabakaran Ponraj; Jianhua Gan; Yang Feng; Zhongyu Zhu; Vidita Choudhry; Xiaodong Xiao; Xinhua Ji; Dimiter S Dimitrov
Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody.
The Journal of biological chemistry 2006;281(23):15829-36.
2006: Zhongyu Zhu; Antony S Dimitrov; Samitabh Chakraborti; Dimana Dimitrova; Xiaodong Xiao; Christopher C Broder; Dimiter S Dimitrov
Development of human monoclonal antibodies against diseases caused by emerging and biodefense-related viruses.
Expert review of anti-infective therapy 2006;4(1):57-66.
2006: Zhongyu Zhu; Antony S Dimitrov; Katharine N Bossart; Gary Crameri; Kimberly A Bishop; Vidita Choudhry; Bruce A Mungall; Yan-Ru Feng; Anil Choudhary; Mei-Yun Zhang; Yang Feng; Lin-Fa Wang; Xiaodong Xiao; Bryan T Eaton; Christopher C Broder; Dimiter S Dimitrov
Potent neutralization of Hendra and Nipah viruses by human monoclonal antibodies.
Journal of virology 2006;80(2):891-9.
2005: Samitabh Chakraborti; Prabakaran Ponraj; Xiaodong Xiao; Dimiter S Dimitrov
The SARS coronavirus S glycoprotein receptor binding domain: fine mapping and functional characterization.
Virology journal 2005;2():73.
2004: Xiaodong Xiao; Dimiter S Dimitrov
The SARS-CoV S glycoprotein.
Cellular and molecular life sciences : CMLS 2004;61(19-20):2428-30.
2004: Xiaodong Xiao; Yang Feng; Samitabh Chakraborti; Dimiter S Dimitrov
Oligomerization of the SARS-CoV S glycoprotein: dimerization of the N-terminus and trimerization of the ectodomain.
Biochemical and biophysical research communications 2004;322(1):93-9.
2004: Mei-Yun Zhang; Xiaodong Xiao; Igor A Sidorov; Vidita Choudhry; Fatim Cham; Peng Fei Zhang; Peter Bouma; Michael B Zwick; Anil Choudhary; David C Montefiori; Christopher C Broder; Dennis R Burton; Gerald V Quinnan; Dimiter S Dimitrov
Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody.
Journal of virology 2004;78(17):9233-42.
2004: Prabakaran Ponraj; Xiaodong Xiao; Dimiter S Dimitrov
A model of the ACE2 structure and function as a SARS-CoV receptor.
Biochemical and biophysical research communications 2004;314(1):235-41.
2003: Xiaodong Xiao; Samitabh Chakraborti; Anthony S Dimitrov; Kosi Gramatikoff; Dimiter S Dimitrov
The SARS-CoV S glycoprotein: expression and functional characterization.
Biochemical and biophysical research communications 2003;312(4):1159-64.
2003: Mei-Yun Zhang; Yuuei Shu; Sanjay Phogat; Xiaodong Xiao; Fatim Cham; Peter Bouma; Anil Choudhary; Yan-Ru Feng; Inaki Sanz; Susanna M Rybak; Christopher C Broder; Gerald V Quinnan; Thomas Evans; Dimiter S Dimitrov
Broadly cross-reactive HIV neutralizing human monoclonal antibody Fab selected by sequential antigen panning of a phage display library.
Journal of immunological methods 2003;283(1-2):17-25.
2003: Xiaodong Xiao; Meropi Athanasiou; Igor A Sidorov; Izumi Horikawa; Gina Cremona; Donald Blair; J Carl Barret; Dimiter S Dimitrov
Role of Ets/Id proteins for telomerase regulation in human cancer cells.
Experimental and molecular pathology 2003;75(3):238-47.
2003: Xiaodong Xiao; Sanjay Phogat; Yuuei Shu; Adhuna Phogat; Yen-Hung Chow; Olivia L Wei; Harris Goldstein; Christopher C Broder; Dimiter S Dimitrov
Purified complexes of HIV-1 envelope glycoproteins with CD4 and CCR5(CXCR4): production, characterization and immunogenicity.
Vaccine 2003;21(27-30):4275-84.
2003: Robert Staudinger; Sanjay Phogat; Xiaodong Xiao; Xiahong Wang; Dimiter S Dimitrov; Susan Zolla-Pazner
Evidence for CD4-enchanced signaling through the chemokine receptor CCR5.
The Journal of biological chemistry 2003;278(12):10389-92.
2002: Xiaodong Xiao; Sanjay Phogat; Igor A Sidorov; J Yang; I Horikawa; D Prieto; J Adelesberger; Richard A Lempicki; J C Barrett; Dimiter S Dimitrov
Identification and characterization of rapidly dividing U937 clones with differential telomerase activity and gene expression profiles: role of c-Myc/Mad1 and Id/Ets proteins.
Leukemia 2002;16(9):1877-80.
2002: Maxime Moulard; Sanjay Phogat; Yuuei Shu; Aran F Labrijn; Xiaodong Xiao; James M Binley; Mei-Yun Zhang; Igor A Sidorov; Christopher C Broder; James Robinson; Paul W H I Parren; Dennis R Burton; Dimiter S Dimitrov
Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6913-8.
2001: Antony S Dimitrov; Xiaodong Xiao; Dimiter S Dimitrov; Robert Blumenthal
Early intermediates in HIV-1 envelope glycoprotein-mediated fusion triggered by CD4 and co-receptor complexes.
The Journal of biological chemistry 2001;276(32):30335-41.
2000: P Hug; Han-Ming Joseph Lin; T Korte; Xiaodong Xiao; Dimiter S Dimitrov; Ji Ming Wang; Anu Puri; Robert Blumenthal
Glycosphingolipids promote entry of a broad range of human immunodeficiency virus type 1 isolates into cell lines expressing CD4, CXCR4, and/or CCR5.
Journal of virology 2000;74(14):6377-85.
2000: Xiaodong Xiao; D Norwood; Yan-Ru Feng; M Moriuchi; Agnes Jones-Trower; Tzanko S Stantchev; H Moriuchi; Christopher C Broder; Dimiter S Dimitrov
Inefficient formation of a complex among CXCR4, CD4 and gp120 in U937 clones resistant to X4 gp120-gp41-mediated fusion.
Experimental and molecular pathology 2000;68(3):139-46.
2000: Xiaodong Xiao; A Kinter; Christopher C Broder; Dimiter S Dimitrov
Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells.
Experimental and molecular pathology 2000;68(3):133-8.
1999: Xiaodong Xiao; L Wu; Tzanko S Stantchev; Yan-Ru Feng; S Ugolini; H Chen; Z Shen; James L Riley; Christopher C Broder; Quentin J Sattentau; Dimiter S Dimitrov
Constitutive cell surface association between CD4 and CCR5.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7496-501.
1999: Dimiter S Dimitrov; D Norwood; Tzanko S Stantchev; Y Feng; Xiaodong Xiao; Christopher C Broder
A mechanism of resistance to HIV-1 entry: inefficient interactions of CXCR4 with CD4 and gp120 in macrophages.
Virology 1999;259(1):1-6.
1999: Riri Shibata; Yan-Ru Feng; Dennis Gee; D Norwood; Xiaodong Xiao; Steven L Zeichner; Malcolm Martin; Dimiter S Dimitrov
Telomere dynamics in monkeys: increased cell turnover in macaques infected with chimeric simian-human immunodeficiency viruses.
Journal of medical primatology 1999;28(1):1-10.
1998: Yan-Ru Feng; D Norwood; Riri Shibata; Dennis Gee; Xiaodong Xiao; Malcolm Martin; Steven L Zeichner; Dimiter S Dimitrov
Telomere dynamics in HIV-1 infected and uninfected chimpanzees measured by an improved method based on high-resolution two-dimensional calibration of DNA sizes.
Journal of medical primatology 1998;27(5):258-65.
1994: S Goodman; Xiaodong Xiao; Robert E Donahue; A Moulton; J Miller; Christopher E Walsh; Neal S Young; R Jude Samulski; A W Nienhuis
Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells.
Blood 1994;84(5):1492-500.
1992: Christopher E Walsh; Johnson Ming-Yu Liu; Xiaodong Xiao; Neal S Young; A W Nienhuis; R Jude Samulski
Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):7257-61.