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Wen Xie

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Jinhan He; Bingfang Hu; Min Huang; Eric E Kelley; Peipei Lu; Xiongjie Shi; Eric R Weidert; Meishu Xu; Wen Xie
Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase sirt3.
Yu Zhang; Zhuo-jia Chen; Qian Fu; Jia-li Li; Long-Shan Liu; Wen-ying Shu; Chang-Xi Wang; Xue-ding Wang; Wen Xie; Min Huang
Associations of ABCB1, NFKB1, CYP3A, and NR1I2 polymorphisms with cyclosporine trough concentrations in Chinese renal transplant recipients.
Mengxi Jiang; Wen Xie
Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor.

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All Publications

2013: Jinhan He; Bingfang Hu; Min Huang; Eric E Kelley; Peipei Lu; Xiongjie Shi; Eric R Weidert; Meishu Xu; Wen Xie
Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase sirt3.
Molecular and cellular biology 2013;33(10):2047-55.
2013: Yu Zhang; Zhuo-jia Chen; Qian Fu; Jia-li Li; Long-Shan Liu; Wen-ying Shu; Chang-Xi Wang; Xue-ding Wang; Wen Xie; Min Huang
Associations of ABCB1, NFKB1, CYP3A, and NR1I2 polymorphisms with cyclosporine trough concentrations in Chinese renal transplant recipients.
Acta pharmacologica Sinica 2013;34(4):555-60.
2013: Mengxi Jiang; Wen Xie
Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor.
Drug metabolism reviews 2013;45(1):156-63.
2013: Lei Xiao; Wen Xie; Mengxi Jiang; Jing Wang; Yonggong Zhai
The emerging role of constitutive androstane receptor and its cross talk with liver X receptors and peroxisome proliferator-activated receptor A in lipid metabolism.
Vitamins and hormones 2013;91():243-58.
2013: Zhimin Ou; Songrong Ren; Marjorie Romkes; Xiongjie Shi; Stephen C Strom; Hongbing Wang; Richard K Gilroy; Roberto Gramignoli; Min Huang; Mengxi Jiang; Levent Kirisci; Caitlin Lynch; Meishu Xu; Wen Xie
Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases.
Molecular endocrinology (Baltimore, Md.) 2013;27(1):106-15.
2012: Jie Gao; Wen Xie
Targeting xenobiotic receptors PXR and CAR for metabolic diseases.
Trends in pharmacological sciences 2012;33(10):552-8.
2011: Simrat P S Saini; Hui Tian; Michael A Tortorici; Hirdesh Uppal; Raman Venkataramanan; Jie Gao; Jung Hoon Lee; Mengxi Jiang; Yongdong Niu; Samuel M Poloyac; Wenxin Qin; Yonggong Zhai; Bin Zhang; Wen Xie
Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice.
Hepatology (Baltimore, Md.) 2011;54(6):2208-17.
2011: Jinhan He; Jung Hoon Lee; Maria Febbraio; Wen Xie
The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease.
Experimental biology and medicine (Maywood, N.J.) 2011;236(10):1116-21.
2011: Taira Wada; Su Zeng; Xiaojuan Chai; Jie Gao; Chibueze A Ihunnah; Kacey Marra; Brian J Philips; J Peter Rubin; Wen Xie
Estrogen sulfotransferase inhibits adipocyte differentiation.
Molecular endocrinology (Baltimore, Md.) 2011;25(9):1612-23.
2011: Chibueze A Ihunnah; Mengxi Jiang; Wen Xie
Nuclear receptor PXR, transcriptional circuits and metabolic relevance.
Biochimica et biophysica acta 2011;1812(8):956-63.
2011: Jiang Li; Chandrashekhar R Gandhi; Xiang Gao; Ramalinga Kuruba; Wen Xie; Yifei Zhang; Song Li
Roles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cells.
Molecular pharmacology 2011;80(1):191-200.
2011: Jinhan He; Shigeru Nishida; Meishu Xu; Makoto Makishima; Wen Xie
PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts.
Gastroenterology 2011;140(7):2095-106.
2011: Zhimin Ou; Taira Wada; Roberto Gramignoli; Song Li; Stephen C Strom; Min Huang; Wen Xie
MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation.
Molecular endocrinology (Baltimore, Md.) 2011;25(4):584-96.
2010: Bin Zhang; Qiuqiong Cheng; Zhimin Ou; Jung Hoon Lee; Meishu Xu; Upasana Kochhar; Songrong Ren; Min Huang; Beth R Pflug; Wen Xie
Pregnane X receptor as a therapeutic target to inhibit androgen activity.
Endocrinology 2010;151(12):5721-9.
2010: Jie Gao; Wen Xie
Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(12):2091-5.
2010: Yonggong Zhai; Tara Wada; Bin Zhang; Shaheen Khadem; Songrong Ren; Ramalinga Kuruba; Song Li; Wen Xie
A functional cross-talk between liver X receptor-α and constitutive androstane receptor links lipogenesis and xenobiotic responses.
Molecular pharmacology 2010;78(4):666-74.
2010: Jung Hoon Lee; Taira Wada; Maria Febbraio; Jinhan He; Tsutomu Matsubara; Min Jae Lee; Frank J Gonzalez; Wen Xie
A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis.
Gastroenterology 2010;139(2):653-63.
2010: Zhimin Ou; Min Huang; Lizi Zhao; Wen Xie
Use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies.
Drug metabolism reviews 2010;42(1):123-31.
2010: Jinhan He; Qiuqiong Cheng; Wen Xie
Minireview: Nuclear receptor-controlled steroid hormone synthesis and metabolism.
Molecular endocrinology (Baltimore, Md.) 2010;24(1):11-21.
2009: Jiang Li; Annette Wilson; Xiang Gao; Ramalinga Kuruba; Youhua Liu; Samuel M Poloyac; Bruce Pitt; Wen Xie; Song Li
Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine.
The Journal of pharmacology and experimental therapeutics 2009;331(1):234-43.
2009: Ming-Jie Liu; Yuki Takahashi; Taira Wada; Jinhan He; Jie Gao; Yanan Tian; Song Li; Wen Xie
The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor.
Molecular pharmacology 2009;76(3):604-11.
2009: Taira Wada; Jie Gao; Wen Xie
PXR and CAR in energy metabolism.
Trends in endocrinology and metabolism: TEM 2009;20(6):273-9.
2009: Jinhan He; Wen Xie
Nuclear xenobiotic receptors: integrating gene regulation to physiological functions.
Progress in molecular biology and translational science 2009;87():87-116.
2009: Michael A Tortorici; Ying Mu; Patrick M Kochanek; Wen Xie; Samuel M Poloyac
Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats.
Critical care medicine 2009;37(1):263-9.
2009: Yi Lu; Qiuyan Chen; Eva Corey; Wen Xie; Jie Fan; Atsushi Mizokami; Jian Zhang
Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone.
Clinical & experimental metastasis 2009;26(2):161-9.
2008: Bin Zhang; Wen Xie; Matthew D Krasowski
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.
Pharmacogenomics 2008;9(11):1695-709.
2008: Taira Wada; Hong Soon Kang; Anton M Jetten; Wen Xie
The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation.
Experimental biology and medicine (Maywood, N.J.) 2008;233(10):1191-201.
2008: Haibiao Gong; Michael J Jarzynka; Timothy J Cole; Jung Hoon Lee; Taira Wada; Bin Zhang; Jie Gao; Wen-Chao Song; Donald B DeFranco; Shi-Yuan Cheng; Wen Xie
Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase.
Cancer research 2008;68(18):7386-93.
2008: Fengtian He; Qiuhong Zhang; Ramalinga Kuruba; Xiang Gao; Jiang Li; Yong Li; Wei Gong; Yu Jiang; Wen Xie; Song Li
Upregulation of decorin by FXR in vascular smooth muscle cells.
Biochemical and biophysical research communications 2008;372(4):746-51.
2008: Jung Hoon Lee; Haibiao Gong; Shaheen Khadem; Yi Lu; Xiang Gao; Song Li; Jian Zhang; Wen Xie
Androgen deprivation by activating the liver X receptor.
Endocrinology 2008;149(8):3778-88.
2008: Hirdesh Uppal; Yonggong Zhai; Archana Gangopadhyay; Shaheen Khadem; Songrong Ren; James A Moser; Wen Xie
Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization.
Hepatology (Baltimore, Md.) 2008;47(4):1331-42.
2008: Jie Zhou; Mingjie Liu; Yonggong Zhai; Wen Xie
The antiapoptotic role of pregnane X receptor in human colon cancer cells.
Molecular endocrinology (Baltimore, Md.) 2008;22(4):868-80.
2008: Taira Wada; Hong Soon Kang; Martin Angers; Gong Herbert; Shikha Bhatia; Shaheen Khadem; Songrong Ren; Ewa Ellis; Stephen C Strom; Anton M Jetten; Wen Xie
Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3).
Molecular pharmacology 2008;73(3):891-9.
2008: Jie Zhou; Maria Febbraio; Taira Wada; Yonggong Zhai; Ramalinga Kuruba; Jinhan He; Jung Hoon Lee; Shaheen Khadem; Songrong Ren; Song Li; Roy L Silverstein; Wen Xie
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis.
Gastroenterology 2008;134(2):556-67.
2008: Qiuhong Zhang; Fengtian He; Ramalinga Kuruba; Xiang Gao; Annette Wilson; Jiang Li; Timothy R Billiar; Bruce R Pitt; Wen Xie; Song Li
FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells.
Cardiovascular research 2008;77(3):560-9.
2008: Jiang Li; Annette Wilson; Ramalinga Kuruba; Qiuhong Zhang; Xiang Gao; Fengtian He; Li-Ming Zhang; Bruce R Pitt; Wen Xie; Song Li
FXR-mediated regulation of eNOS expression in vascular endothelial cells.
Cardiovascular research 2008;77(1):169-77.
2007: M Teresa Sáenz-Robles; David Toma; Paul Cantalupo; Jie Zhou; Gong Herbert; C Edwards; James M Pipas; Wen Xie
Repression of intestinal drug metabolizing enzymes by the SV40 large T antigen.
Oncogene 2007;26(35):5124-31.
2007: Gong Herbert; Ping Guo; Yonggong Zhai; Jie Zhou; Hirdesh Uppal; Michael J Jarzynka; Wen-Chao Song; Shi-Yuan Cheng; Wen Xie
Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor.
Molecular endocrinology (Baltimore, Md.) 2007;21(8):1781-90.
2007: William Alaynick; Richard P Kondo; Wen Xie; Weimin He; Catherine Dufour; Michael Downes; johan jonker; Wayne Giles; Robert K Naviaux; Vincent Giguère; Ronald M Evans
ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart.
Cell metabolism 2007;6(1):13-24.
2007: Peter Wipf; Gong Herbert; Jelena M Janjic; Song Li; Billy W Day; Wen Xie
New opportunities for pregnane X receptor (PXR) targeting in drug development. lessons from Enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues.
Mini reviews in medicinal chemistry 2007;7(6):617-25.
2007: Hirdesh Uppal; Simrat P S Saini; Antonio Moschetta; Ying Mu; Jie Zhou; Gong Herbert; Yonggong Zhai; Songrong Ren; George K Michalopoulos; David J Mangelsdorf; Wen Xie
Activation of LXRs prevents bile acid toxicity and cholestasis in female mice.
Hepatology (Baltimore, Md.) 2007;45(2):422-32.
2007: Yonggong Zhai; Harish V Pai; Jie Zhou; Janet A Amico; Regis R Vollmer; Wen Xie
Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis.
Molecular endocrinology (Baltimore, Md.) 2007;21(1):138-47.
2006: Wen Xie; Yanan Tian
Xenobiotic receptor meets NF-kappaB, a collision in the small bowel.
Cell metabolism 2006;4(3):177-8.
2006: Jie Zhou; Yonggong Zhai; Ying Mu; Gong Herbert; Hirdesh Uppal; David Toma; Songrong Ren; Ronald M Evans; Wen Xie
A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway.
The Journal of biological chemistry 2006;281(21):15013-20.
2006: Ying Mu; Jinnan Zhang; Shimin Zhang; Hong-Hao Zhou; David Toma; Songrong Ren; Leaf Huang; Maria Yaramus; Andrew Baum; Raman Venkataramanan; Wen Xie
Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1369-77.
2006: Fengtian He; Jiang Li; Ying Mu; Ramalinga Kuruba; Zheng Ma; Annette Wilson; Sean Alber; Yu Jiang; Troy Stevens; simon simon watkins; Bruce R Pitt; Wen Xie; Song Li
Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells.
Circulation research 2006;98(2):192-9.
2006: Gong Herbert; Shivendra V Singh; Sharda P Singh; Ying Mu; Jung Hoon Lee; Simrat P S Saini; David Toma; Songrong Ren; Valerian E Kagan; Billy W Day; Piotr Zimniak; Wen Xie
Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells.
Molecular endocrinology (Baltimore, Md.) 2006;20(2):279-90.
2005: Jie Zhou; J Zhang; Wen Xie
Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyl-transferases.
Current drug metabolism 2005;6(4):289-98.
2005: Ying Mu; Corey R J Stephenson; Christopher Kendall; Simrat P S Saini; David Toma; Songrong Ren; Hongbo Cai; Stephen C Strom; Billy W Day; Peter Wipf; Wen Xie
A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development.
Molecular pharmacology 2005;68(2):403-13.
2005: Simrat P S Saini; Ying Mu; Gong Herbert; David Toma; Hirdesh Uppal; Songrong Ren; Song Li; Samuel M Poloyac; Wen Xie
Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice.
Hepatology (Baltimore, Md.) 2005;41(3):497-505.
2005: Jelena M Janjic; Ying Mu; Christopher Kendall; Corey R J Stephenson; Raghavan Balachandran; Brianne S Raccor; Ying Lu; Guangyu Zhu; Wen Xie; Peter Wipf; Billy W Day
New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides.
Bioorganic & medicinal chemistry 2005;13(1):157-64.
2005: Gong Herbert; Michael W Sinz; Yan Feng; Taosheng Chen; Raman Venkataramanan; Wen Xie
Animal models of xenobiotic receptors in drug metabolism and diseases.
Methods in enzymology 2005;400():598-618.
2005: Hirdesh Uppal; David Toma; Simrat P S Saini; Songrong Ren; Thomas J Jones; Wen Xie
Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice.
Hepatology (Baltimore, Md.) 2005;41(1):168-76.
2004: Samuel M Poloyac; Michael A Tortorici; Danielle I Przychodzin; Robert B Reynolds; Wen Xie; Reginald F Frye; Michael A Zemaitis
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(7):727-33.
2004: Wen Xie; Hirdesh Uppal; Simrat P S Saini; Ying Mu; Joanna M Little; Anna Radominska-Pandya; Michael A Zemaitis
Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism.
Drug discovery today 2004;9(10):442-9.
2004: Gong Herbert; Wen Xie
Orphan nuclear receptors, PXR and LXR: new ligands and therapeutic potential.
Expert opinion on therapeutic targets 2004;8(1):49-54.
2004: Simrat P S Saini; Junichiro Sonoda; Li Xu; David Toma; Hirdesh Uppal; Ying Mu; Songrong Ren; David D Moore; Ronald M Evans; Wen Xie
A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.
Molecular pharmacology 2004;65(2):292-300.
2003: John M Rosenfeld; Reynaldo Vargas; Wen Xie; Ronald M Evans
Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1268-82.
2003: Wen Xie; Mei-Fei Yeuh; Anna Radominska-Pandya; Simrat P S Saini; Yoichi Negishi; Bobbie Sue Bottroff; Geraldine Y Cabrera; Robert H Tukey; Ronald M Evans
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4150-5.
2003: Wen Xie; Hirdesh Uppal
Drug discovery perspective of chemical-driven mouse mutagenesis.
Drug discovery today 2003;8(5):199.
2003: Junichiro Sonoda; John M Rosenfeld; Li Xu; Ronald M Evans; Wen Xie
A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection.
Current drug metabolism 2003;4(1):59-72.
2002: Junichiro Sonoda; Wen Xie; John M Rosenfeld; Joyce L Barwick; Philip S Guzelian; Ronald M Evans
Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13801-6.
2002: Wen Xie; Ronald M Evans
Pharmaceutical use of mouse models humanized for the xenobiotic receptor.
Drug discovery today 2002;7(9):509-15.
2001: Wen Xie; Ronald M Evans
Orphan nuclear receptors: the exotics of xenobiotics.
The Journal of biological chemistry 2001;276(41):37739-42.
2001: Y Shi; Michael Downes; Wen Xie; Hung-Ying Kao; P Ordentlich; Chih-Cheng Tsai; M Hon; Ronald M Evans
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.
Genes & development 2001;15(9):1140-51.
2001: Wen Xie; A Radominska-Pandya; Yanhong Shi; CM Simon; Michael C Nelson; Estelita S Ong; D J Waxman; Ronald M Evans
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3375-80.
2000: Wen Xie; Joyce L Barwick; CM Simon; A M Pierce; S Safe; B Blumberg; Philip S Guzelian; Ronald M Evans
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR.
Genes & development 2000;14(23):3014-23.
2000: Wen Xie; Joyce L Barwick; Michael Downes; B Blumberg; CM Simon; Michael C Nelson; Brent A Neuschwander-Tetri; E M Brunt; Philip S Guzelian; Ronald M Evans
Humanized xenobiotic response in mice expressing nuclear receptor SXR.
Nature 2000;406(6794):435-9.
1999: Wen Xie; H Hong; N N Yang; RJ Lin; CM Simon; M R Stallcup; Ronald M Evans
Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2.
Molecular endocrinology (Baltimore, Md.) 1999;13(12):2151-62.
1999: Huaming Chen; RJ Lin; Wen Xie; D Wilpitz; Ronald M Evans
Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.
Cell 1999;98(5):675-86.
1999: P Ordentlich; Michael Downes; Wen Xie; Anna Genin; Nancy B Spinner; Ronald M Evans
Unique forms of human and mouse nuclear receptor corepressor SMRT.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2639-44.