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Weidong Xiong

Research Profile

Chemicals & Drugs

Living Beings

Procedures

Disorders

Genes & Molecular Sequences

Transgenes

Anatomy

Physiology

Transduction, Genetic

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Publications

TOP 3
Yohei Mineharu; Mariana Puntel; Weidong Xiong; Kader Yagiz; A K M Ghulam Muhammad; Michael A Curran; Adrina Kocharian; Kurt M Kroeger; Eva Levy; Chunyan Liu; Pedro R Lowenstein; Claudia Lugo; James P Allison; Marianela Candolfi; Maria G Castro
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.
A K M Ghulam Muhammad; Catherine Farrokhi; Kyle R Kelson; Kurt M Kroeger; Liliana Lacayo; Chunyan Liu; Pedro R Lowenstein; Philip Ng; Donna Palmer; Robert N Pechnick; Mariana Puntel; Alireza Salem; Weidong Xiong; Maria G Castro
Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial.
Gwendalyn D King; Kurt M Kroeger; Daniel Larocque; Chunyan Liu; Maria G Castro; Kyle R Kelson; A K M Ghulam Muhammad; Nicholas S R Sanderson; Weidong Xiong; Pedro R Lowenstein
Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen.

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All Publications

2012: Yohei Mineharu; Mariana Puntel; Weidong Xiong; Kader Yagiz; A K M Ghulam Muhammad; Michael A Curran; Adrina Kocharian; Kurt M Kroeger; Eva Levy; Chunyan Liu; Pedro R Lowenstein; Claudia Lugo; James P Allison; Marianela Candolfi; Maria G Castro
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2012;9(4):827-43.
2012: A K M Ghulam Muhammad; Catherine Farrokhi; Kyle R Kelson; Kurt M Kroeger; Liliana Lacayo; Chunyan Liu; Pedro R Lowenstein; Philip Ng; Donna Palmer; Robert N Pechnick; Mariana Puntel; Alireza Salem; Weidong Xiong; Maria G Castro
Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial.
Human gene therapy methods 2012;23(4):271-84.
2011: Gwendalyn D King; Kurt M Kroeger; Daniel Larocque; Chunyan Liu; Maria G Castro; Kyle R Kelson; A K M Ghulam Muhammad; Nicholas S R Sanderson; Weidong Xiong; Pedro R Lowenstein
Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(10):1793-801.
2010: Marianela Candolfi; Weidong Xiong; Kader Yagiz; Chunyan Liu; A K M G Muhammad; Mariana Puntel; David Foulad; Ali Zadmehr; Gabrielle E Ahlzadeh; Kurt M Kroeger; Matthew Tesarfreund; Sharon Lee; Waldemar Debinski; Dhruv Sareen; Clive Svendsen; Ronald Rodriguez; Pedro R Lowenstein; Maria G Castro
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):20021-6.
2010: Kurt M Kroeger; A K M Ghulam Muhammad; Gregory J Baker; Hikmat Assi; Mia K Wibowo; Weidong Xiong; Kader Yagiz; Marianela Candolfi; Pedro R Lowenstein; Maria G Castro
Gene therapy and virotherapy: novel therapeutic approaches for brain tumors.
Discovery medicine 2010;10(53):293-304.
2010: A K M G Muhammad; Mariana Puntel; Marianela Candolfi; A Salem; K Yagiz; C Farrokhi; Kurt M Kroeger; Weidong Xiong; James F Curtin; Chunyan Liu; K Lawrence; N S Bondale; J Lerner; G J Baker; D Foulad; Robert N Pechnick; Donna Palmer; P Ng; Pedro R Lowenstein; Maria G Castro
Study of the efficacy, biodistribution, and safety profile of therapeutic gutless adenovirus vectors as a prelude to a phase I clinical trial for glioblastoma.
Clinical pharmacology and therapeutics 2010;88(2):204-13.
2010: Mariana Puntel; A K M G Muhammad; Marianela Candolfi; Alireza Salem; Kader Yagiz; Catherine Farrokhi; Kurt M Kroeger; Weidong Xiong; James F Curtin; Chunyan Liu; Niyati S Bondale; Jonathan Lerner; Robert N Pechnick; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics.
Journal of virology 2010;84(12):6007-17.
2010: Weidong Xiong; Marianela Candolfi; Chunyan Liu; A K M Ghulam Muhammad; Kader Yagiz; Mariana Puntel; Peter F Moore; Julie Avalos; John D Young; Dorothy Khan; Randy Donelson; G Elizabeth Pluhar; John R Ohlfest; Kolja Wawrowsky; Pedro R Lowenstein; Maria G Castro
Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial.
PloS one 2010;5(6):e11074.
2009: Marianela Candolfi; Kader Yagiz; David Foulad; Gabrielle E Alzadeh; Matthew Tesarfreund; A K M Ghulam Muhammad; Mariana Puntel; Kurt M Kroeger; Chunyan Liu; Sharon Lee; James F Curtin; Gwendalyn D King; Jonathan Lerner; Katsuaki Sato; Yohei Mineharu; Weidong Xiong; Pedro R Lowenstein; Maria G Castro
Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4401-14.
2009: Mariana Puntel; R J Barrett; Sonali Mondkar; V Saxena; Kurt M Kroeger; A K M Muhammad; Chunyan Liu; N Bondale; Sandra A Sciascia; Weidong Xiong; Y Shi; A Salem; A Zadmehr; P Huynh; Donna Palmer; P Ng; Maria G Castro; Pedro R Lowenstein
Herpes simplex virus type 1 thymidine kinase sequence fused to the lacz gene increases levels of {beta}-galactosidase activity per genome of high-capacity but not first-generation adenoviral vectors in vitro and in vivo.
Journal of virology 2009;83(4):2004-10.
2009: James F Curtin; Naiyou Liu; Marianela Candolfi; Weidong Xiong; Hikmat Assi; Kader Yagiz; Matthew R Edwards; Kathrin S Michelsen; Kurt M Kroeger; Chunyan Liu; A K M Ghulam Muhammad; Mary C Clark; Moshe Arditi; Begonya Comin-Anduix; Antoni Ribas; Pedro R Lowenstein; Maria G Castro
HMGB1 mediates endogenous TLR2 activation and brain tumor regression.
PLoS medicine 2009;6(1):e10.
2008: Gwendalyn D King; A K M Ghulam Muhammad; Weidong Xiong; Kurt M Kroeger; Mariana Puntel; Daniel Larocque; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity.
Journal of virology 2008;82(9):4680-4.
2008: Weidong Xiong; Marianela Candolfi; Kurt M Kroeger; Mariana Puntel; Sonali Mondkar; Daniel Larocque; Chunyan Liu; James F Curtin; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):343-51.
2007: Carlos Barcia; Maximiliano Jimenez-Dalmaroni; Kurt M Kroeger; Mariana Puntel; Alison J Rapaport; Daniel Larocque; Gwendalyn D King; Stephen A Johnson; Chunyan Liu; Weidong Xiong; Marianela Candolfi; Sonali Mondkar; Philip Ng; Donna Palmer; Maria G Castro; Pedro R Lowenstein
One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2154-63.
2007: Marianela Candolfi; G Elizabeth Pluhar; Kurt M Kroeger; Mariana Puntel; James Curtin; Carlos Barcia; A K M Ghulam Muhammad; Weidong Xiong; Chunyan Liu; Sonali Mondkar; William Kuoy; Terry Kang; Elizabeth A McNeil; Andrew Freese; John R Ohlfest; Peter F Moore; Donna Palmer; Phillip Ng; John D Young; Pedro R Lowenstein; Maria G Castro
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
Neuro-oncology 2007;9(3):245-58.
2006: Mariana Puntel; James F Curtin; Jeffrey M Zirger; A K M Muhammad; Weidong Xiong; Chunyan Liu; Jinwei Hu; Kurt M Kroeger; P Czer; Sandra A Sciascia; Sonali Mondkar; Pedro R Lowenstein; Maria G Castro
Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.
Human gene therapy 2006;17(5):531-44.
2006: Weidong Xiong; Shyam Goverdhana; Sandra A Sciascia; Marianela Candolfi; Jeffrey M Zirger; Carlos Barcia; James F Curtin; Gwendalyn D King; Gabriela Jaita; Chunyan Liu; Kurt M Kroeger; Hasmik Agadjanian; Lali K Medina-Kauwe; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.
Journal of virology 2006;80(1):27-37.
2005: Adriana Seilicovich; Daniel Pisera; Sandra A Sciascia; Marianela Candolfi; Mariana Puntel; Weidong Xiong; Gabriela Jaita; Maria G Castro
Gene therapy for pituitary tumors.
Current gene therapy 2005;5(6):559-72.
2005: Sumia Ali; Gwendalyn D King; James F Curtin; Marianela Candolfi; Weidong Xiong; Chunyan Liu; Mariana Puntel; Queng Cheng; Jesus Prieto; Antoni Ribas; Jerzy W Kupiec-Weglinski; Nico van Rooijen; Hans Lassmann; Pedro R Lowenstein; Maria G Castro
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
Cancer research 2005;65(16):7194-204.
2005: Shyam Goverdhana; Mariana Puntel; Weidong Xiong; Jeffrey M Zirger; Carlos Barcia; James F Curtin; E B Soffer; Sonali Mondkar; Gwendalyn D King; Jinwei Hu; Sandra A Sciascia; Marianela Candolfi; D S Greengold; Pedro R Lowenstein; Maria G Castro
Regulatable gene expression systems for gene therapy applications: progress and future challenges.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):189-211.
2004: Sumia Ali; James F Curtin; Jeffrey M Zirger; Weidong Xiong; Gwendalyn D King; Carlos Barcia; Chunyan Liu; Mariana Puntel; Shyam Goverdhana; Pedro R Lowenstein; Maria G Castro
Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(6):1071-84.
2003: Daniel Stone; Weidong Xiong; Judith C Williams; Anne David; Pedro R Lowenstein; Maria G Castro
Adenovirus expression of IL-1 and NF-kappaB inhibitors does not inhibit acute adenoviral-induced brain inflammation, but delays immune system-mediated elimination of transgene expression.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(3):400-11.
1999: Maria G Castro; J R Davis; Weidong Xiong; Pedro R Lowenstein
Recent developments in gene therapy: applications for the treatment of pituitary tumours.
Baillière's best practice & research. Clinical endocrinology & metabolism 1999;13(3):431-49.