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Yue Xiong

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Chemicals & Drugs

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Di Zhao; Xin Zhou; Shao-Wu Zou; Bo Dong; Qun-Ying Lei; Ying Liu; Yan Mo; Ping Wang; Yue Xiong; Yan-Hui Xu; Kun-Liang Guan
Lysine-5 acetylation negatively regulates lactate dehydrogenase a and is decreased in pancreatic cancer.
Dan Ye; Shenghong Ma; Yue Xiong; Kun-Liang Guan
R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis.
Robert J Duronio; Yue Xiong
Signaling pathways that control cell proliferation.

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2013: Di Zhao; Xin Zhou; Shao-Wu Zou; Bo Dong; Qun-Ying Lei; Ying Liu; Yan Mo; Ping Wang; Yue Xiong; Yan-Hui Xu; Kun-Liang Guan
Lysine-5 acetylation negatively regulates lactate dehydrogenase a and is decreased in pancreatic cancer.
Cancer cell 2013;23(4):464-76.
2013: Dan Ye; Shenghong Ma; Yue Xiong; Kun-Liang Guan
R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis.
Cancer cell 2013;23(3):274-6.
2013: Robert J Duronio; Yue Xiong
Signaling pathways that control cell proliferation.
Cold Spring Harbor perspectives in biology 2013;5(3):a008904.
2013: H Yang; D Ye; J-Y Zhang; H-G Zhu; F Bai; Kun-Liang Guan; Z-Q Ling; Jing Liu; Ying Liu; S-H Ma; Z-D Xu; Yue Xiong
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation.
Oncogene 2013;32(5):663-9.
2012: Hui Yang; Dan Ye; Kun-Liang Guan; Yue Xiong
IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(20):5562-71.
2012: Yue Xiong; Kun-Liang Guan
Mechanistic insights into the regulation of metabolic enzymes by acetylation.
The Journal of cell biology 2012;198(2):155-64.
2012: Dan Ye; Yue Xiong; Kun-Liang Guan
The mechanisms of IDH mutations in tumorigenesis.
Cell research 2012;22(7):1102-4.
2012: Mengtao Xiao; Yue Xiong; Wei Xu; Yanhui Xu; Chen Yang; Hui Yang; Dan Ye; Shimin Zhao; Honguang Zhu; Huaipeng Lin; Lixia Liu; Ying Liu; Shenghong Ma; Kun-Liang Guan
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.
Genes & development 2012;26(12):1326-38.
2012: Eric K Oermann; Jing Wu; Kun-Liang Guan; Yue Xiong
Alterations of metabolic genes and metabolites in cancer.
Seminars in cell & developmental biology 2012;23(4):370-80.
2012: Michele D Kassmeier; Sushil Kumar; Koushik Mondal; Victoria L Palmer; Greg A Perry; Prafulla Raval; Dirk K Anderson; Pawel Ciborowski; Sarah Jackson; Yue Xiong; Patrick C Swanson
VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity.
The EMBO journal 2012;31(4):945-58.
2011: Tadashi Nakagawa; Yue Xiong
Chromatin regulation by CRL4 E3 ubiquitin ligases: CUL4B targets WDR5 ubiquitylation in the nucleus.
Cell cycle (Georgetown, Tex.) 2011;10(24):4197-8.
2011: Tadashi Nakagawa; Yue Xiong
X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression.
Molecular cell 2011;43(3):381-91.
2011: Wenqing Jiang; Qunying Lei; Yan Lin; Shiwen Wang; Mengtao Xiao; Yue Xiong; Kun-Liang Guan; Lisha Zhou; Shimin Zhao
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.
Molecular cell 2011;43(1):33-44.
2011: Tiffany Hung; Manolis Kellis; Seung K Kim; Ashley K Koegel; Benjamin Kong; Yojiro Kotake; Anita Langerød; Michael F Lin; Nilay Shah; Saraswati Sukumar; Christopher B Umbricht; Marc van de Vijver; Pei Wang; Yu Wang; Yulei Wang; Michael L Whitfield; David J Wong; Yue Xiong; Anne-Lise Børresen-Dale; Gavin D Grant; Hugo M Horlings; Howard Y Chang
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters.
Nature genetics 2011;43(7):621-9.
2011: Lei Lv; Gang Wang; Yue Xiong; Yanping Xu; Zhengyu Zha; Heng Zhang; Di Zhao; Yajing Chu; Kun-Liang Guan; Yiran Huang; Dong Li; Zi Li; Ruiting Lin; Ying Liu; Qun-Ying Lei
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.
Molecular cell 2011;42(6):719-30.
2011: Y Kotake; T Nakagawa; K Kitagawa; S Suzuki; N Liu; M Kitagawa; Yue Xiong
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene.
Oncogene 2011;30(16):1956-62.
2011: Zhijun Li; Feng Bai; Zhijun Li; Matthew D Smith; Gabrielle Whitewolf; Ran Jin; Yue Xiong
Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis.
Cancer research 2011;71(8):2969-77.
2011: Yaxue Zeng; Yojiro Kotake; Zhijun Li; Matthew D Smith; Yue Xiong
p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb.
Cancer research 2011;71(7):2781-92.
2011: Wei Xu; Hui Yang; Ying Liu; Ying Yang; Ping Wang; Se-Hee Kim; Shinsuke Ito; Chen Yang; Ping Wang; Meng-Tao Xiao; Li-xia Liu; Wen-qing Jiang; Jing Liu; Jin-ye Zhang; Bin Wang; Stephen Frye; Yi Zhang; Yan-hui Xu; Qun-Ying Lei; Kun-Liang Guan; Shi-min Zhao; Yue Xiong
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
Cancer cell 2011;19(1):17-30.
2010: Jun Yan; Yue Xiong
Targeted ubiquitylation: the prey becomes predator.
Molecular cell 2010;40(6):853-5.
2010: Yue Xiong
Targeting p21 degradation locally.
Developmental cell 2010;19(5):641-3.
2010: Hyun O Lee; Sima J Zacharek; Yue Xiong; Robert J Duronio
Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.
Molecular biology of the cell 2010;21(21):3639-53.
2010: Qijun Wang; Yakun Zhang; Chen Yang; Hui Xiong; Yan Lin; Jun Yao; Hong Li; Lu Xie; Wei Zhao; Yufeng Yao; Zhi-Bin Ning; Rong Zeng; Yue Xiong; Kun-Liang Guan; Shimin Zhao; Guo-Ping Zhao
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.
Science (New York, N.Y.) 2010;327(5968):1004-7.
2010: Shimin Zhao; Wei Xu; Wenqing Jiang; Wei Yu; Yan Lin; Tengfei Zhang; Jun Yao; Li Zhou; Yaxue Zeng; Hong Li; Yixue Li; Jiong Shi; Wenlin An; Susan M Hancock; Fuchu He; Lunxiu Qin; Jason Chin; Pengyuan Yang; Xian Chen; Qunying Lei; Yue Xiong; Kun-Liang Guan
Regulation of cellular metabolism by protein lysine acetylation.
Science (New York, N.Y.) 2010;327(5968):1000-4.
2009: Sarah Jackson; Yue Xiong
CRL4s: the CUL4-RING E3 ubiquitin ligases.
Trends in biochemical sciences 2009;34(11):562-70.
2009: Heng Zhang; Chen-Ying Liu; Zheng-Yu Zha; Bin Zhao; Jun Yao; Shimin Zhao; Yue Xiong; Qun-Ying Lei; Kun-Liang Guan
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.
The Journal of biological chemistry 2009;284(20):13355-62.
2009: Wei Yu; Yan Lin; Jun Yao; Wei Huang; Qun-Ying Lei; Yue Xiong; Shimin Zhao; Kun-Liang Guan
Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals.
The Journal of biological chemistry 2009;284(20):13669-75.
2009: Zhijun Li; Feng Bai; Matthew D Smith; Jerry Usary; Cheng Fan; Sung-Yun Pai; I-Cheng Ho; Charles M Perou; Yue Xiong
CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.
Cancer cell 2009;15(5):389-401.
2009: Shimin Zhao; Yan Lin; Wei Xu; Wenqing Jiang; Zhengyu Zha; Pu Wang; Wei Yu; Zhiqiang Li; Lingling Gong; Yingjie Peng; Jianping Ding; Qunying Lei; Kun-Liang Guan; Yue Xiong
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.
Science (New York, N.Y.) 2009;324(5924):261-5.
2009: Sarah Jackson; Yue Xiong
Targeting protein ubiquitylation: DDB1 takes its RING off.
Nature cell biology 2009;11(4):379-81.
2009: Yojiro Kotake; Yaxue Zeng; Yue Xiong
DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation.
Cancer research 2009;69(5):1809-14.
2008: Nick van Buuren; Brianne Couturier; Yue Xiong; Michele Barry
Ectromelia virus encodes a novel family of F-box proteins that interact with the SCF complex.
Journal of virology 2008;82(20):9917-27.
2008: Chad M McCall; Paula L Miliani de Marval; Paul Chastain; Sarah C Jackson; Yizhou J He; Yojiro Kotake; Jeanette Gowen Cook; Yue Xiong
Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.
Molecular and cellular biology 2008;28(18):5621-33.
2008: Yu Zhang; Suhua Feng; Fangfang Chen; Haodong Chen; Jia Wang; Chad McCall; Yue Xiong; Xing Wang Deng
Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes.
The Plant cell 2008;20(6):1437-55.
2008: Brianne A Wilton; Stephanie Campbell; Nicholas Van Buuren; Robyn Garneau; Manabu Furukawa; Yue Xiong; Michele Barry
Ectromelia virus BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3-based ubiquitin ligases.
Virology 2008;374(1):82-99.
2008: Jian Hu; Sima Zacharek; Yizhou Joseph He; Hyun Lee; Stuart D. Shumway; Robert J Duronio; Yue Xiong
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.
Genes & development 2008;22(7):866-71.
2008: Qun-Ying Lei; Heng Zhang; Bin Zhao; Zheng-Yu Zha; Feng Bai; Zhijun Li; Shimin Zhao; Yue Xiong; Kun-Liang Guan
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway.
Molecular and cellular biology 2008;28(7):2426-36.
2008: Jae-Hoon Lee; William Terzaghi; Giuliana Gusmaroli; Jean-Benoit F Charron; Hye-Jin Yoon; Haodong Chen; Yizhou Joseph He; Yue Xiong; Xing Wang Deng
Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases.
The Plant cell 2008;20(1):152-67.
2007: Matthew Robert Ramsey; Janakiraman Krishnamurthy; Zhijun Li; Chad Torrice; Weili Lin; Daniel R Carrasco; Keith L Ligon; Yue Xiong; Norman E Sharpless
Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.
Cancer research 2007;67(10):4732-41.
2007: Zhijun Li; Feng Bai; Matthew D Smith; Yue Xiong
p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers.
Cancer research 2007;67(7):3162-70.
2007: Feng Bai; Zhijun Li; Toru Nishikawa; Matthew D Smith; Yue Xiong
p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors.
Molecular and cellular biology 2007;27(4):1495-504.
2007: Yojiro Kotake; Ru Cao; Patrick Viatour; Julien Sage; Yi Zhang; Yue Xiong
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.
Genes & development 2007;21(1):49-54.
2006: Yizhou Joseph He; Chad M McCall; Jian Hu; Yaxue Zeng; Yue Xiong
DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.
Genes & development 2006;20(21):2949-54.
2006: P Andrews; Y J He; Yue Xiong
Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function.
Oncogene 2006;25(33):4534-48.
2006: Stuart D. Shumway; Yue Xiong
Twice primed: cyclin E is phosphorylated and isomerized before being ubiquitinated.
Molecular cell 2006;23(2):149-50.
2006: Feng Bai; Zhijun Li; Pier Paolo Pandolfi; Yue Xiong
p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control.
Molecular and cellular biology 2006;26(12):4564-76.
2006: Hengbin Wang; Ling Zhai; Jun Xu; Heui-Yun Joo; Sarah Jackson; Hediye Erdjument-Bromage; Paul Tempst; Yue Xiong; Yi Zhang
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.
Molecular cell 2006;22(3):383-94.
2006: Yue Xiong; Yojiro Kotake
No exit strategy? No problem: APC inhibits beta-catenin inside the nucleus.
Genes & development 2006;20(6):637-42.
2006: Jian Hu; Yue Xiong
An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage.
The Journal of biological chemistry 2006;281(7):3753-6.
2005: Sima J Zacharek; Yue Xiong; Stuart D. Shumway
Negative regulation of TSC1-TSC2 by mammalian D-type cyclins.
Cancer research 2005;65(24):11354-60.
2005: Satyajit K Karnik; Christina M Hughes; Xueying Gu; Orit Rozenblatt-Rosen; Graeme W McLean; Yue Xiong; Matthew Meyerson; Seung K Kim
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(41):14659-64.
2005: Zhijun Li; Yue Xiong
Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues.
Oncogene 2005;24(17):2787-95.
2005: Manabu Furukawa; Paul S Andrews; Yue Xiong
Assays for RING family ubiquitin ligases.
Methods in molecular biology (Clifton, N.J.) 2005;301():37-46.
2005: Chad M McCall; Jian Hu; Yue Xiong
Recruiting substrates to cullin 4-dependent ubiquitin ligases by DDB1.
Cell cycle (Georgetown, Tex.) 2005;4(1):27-9.
2005: Manabu Furukawa; Yue Xiong
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
Molecular and cellular biology 2005;25(1):162-71.
2004: Seth J Goldenberg; Thomas C Cascio; Stuart D. Shumway; Kenneth C Garbutt; Jidong Liu; Yue Xiong; Ning Zheng
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.
Cell 2004;119(4):517-28.
2004: Jian Hu; Chad M McCall; Tomohiko Ohta; Yue Xiong
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.
Nature cell biology 2004;6(10):1003-9.
2004: Zhijun Li; Feng Bai; Tateki Tsutsui; Hiroaki Kiyokawa; Yue Xiong
Genetic evidence for functional dependency of p18Ink4c on Cdk4.
Molecular and cellular biology 2004;24(15):6653-64.
2004: Suhua Feng; Yunping Shen; James A Sullivan; Vicente Rubio; Yue Xiong; Tai-ping Sun; Xing Wang Deng
Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation.
The Plant cell 2004;16(7):1870-82.
2003: Yanping Zhang; Gabrielle White Wolf; Krishna Bhat; Aiwen Jin; Theresa Allio; William A Burkhart; Yue Xiong
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway.
Molecular and cellular biology 2003;23(23):8902-12.
2003: Manabu Furukawa; Yizhou Joseph He; Christoph H Borchers; Yue Xiong
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
Nature cell biology 2003;5(11):1001-7.
2003: Eric D Tang; Cun-Yu Wang; Yue Xiong; Kun-Liang Guan
A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha.
The Journal of biological chemistry 2003;278(39):37297-305.
2003: Jennifer J Michel; Joseph F McCarville; Yue Xiong
A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression.
The Journal of biological chemistry 2003;278(25):22828-37.
2003: Tom Luedde; Maria E Rodriguez; Frank Tacke; Yue Xiong; David A Brenner; Christian Trautwein
p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver.
Hepatology (Baltimore, Md.) 2003;37(4):833-41.
2003: Feng Bai; Zhijun Li; Virginia L Godfrey; Yue Xiong
Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis.
Molecular and cellular biology 2003;23(4):1269-77.
2003: Stuart D. Shumway; Yong Li; Yue Xiong
14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin.
The Journal of biological chemistry 2003;278(4):2089-92.
2002: Jidong Liu; Manabu Furukawa; Tomohiro Matsumoto; Yue Xiong
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.
Molecular cell 2002;10(6):1511-8.
2002: Michelle R Tourigny; Josie Ursini-Siegel; Hayyoung Lee; Kai-Michael Toellner; Adam F Cunningham; David S Franklin; Scott Ely; Meihong Chen; Xiao-Feng Qin; Yue Xiong; Ian C M MacLennan; Selina Chen-Kiang
CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells.
Immunity 2002;17(2):179-89.
2002: Manabu Furukawa; Tomohiko Ohta; Yue Xiong
Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins.
The Journal of biological chemistry 2002;277(18):15758-65.
2002: Wendell G Yarbrough; Mika Bessho; Adam M Zanation; John E Bisi; Yue Xiong
Human tumor suppressor ARF impedes S-phase progression independent of p53.
Cancer research 2002;62(4):1171-7.
2001: G I Kovalev; David S Franklin; V McNeil Coffield; Yue Xiong; Lishan Su
An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3285-92.
2001: Yi Zhang; Yue Xiong
A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation.
Science (New York, N.Y.) 2001;292(5523):1910-5.
2001: Yanping Zhang; Yue Xiong
Control of p53 ubiquitination and nuclear export by MDM2 and ARF.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(4):175-86.
2001: Tomohiko Ohta; Yue Xiong
Phosphorylation- and Skp1-independent in vitro ubiquitination of E2F1 by multiple ROC-cullin ligases.
Cancer research 2001;61(4):1347-53.
2001: P Yu; B Huang; M Shen; C Lau; E Chan; J Michel; Yue Xiong; D G Payan; Y Luo
p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues.
Oncogene 2001;20(4):484-9.
2000: Manabu Furukawa; Yi Zhang; Joseph F McCarville; Tomohiko Ohta; Yue Xiong
The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1.
Molecular and cellular biology 2000;20(21):8185-97.
2000: David S Franklin; Virginia L Godfrey; Deborah A O'Brien; C Deng; Yue Xiong
Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity.
Molecular and cellular biology 2000;20(16):6147-58.
1999: Tomohiko Ohta; Jennifer J Michel; Yue Xiong
Association with cullin partners protects ROC proteins from proteasome-dependent degradation.
Oncogene 1999;18(48):6758-66.
1999: Yi Zhang; Yue Xiong
Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53.
Molecular cell 1999;3(5):579-91.
1999: Tomohiko Ohta; Jennifer J Michel; Arndt Schottelius; Yue Xiong
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.
Molecular cell 1999;3(4):535-41.
1999: Serge Y Fuchs; Angus Chen; Yue Xiong; Zhen-Qiang Pan; Ze'ev Ronai
HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin.
Oncogene 1999;18(12):2039-46.
1999: S J Noh; Yong Li; Yue Xiong; Kun-Liang Guan
Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6.
Cancer research 1999;59(3):558-64.
1998: Maimoona A Zariwala; J Liu; Yue Xiong
Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.
Oncogene 1998;17(21):2787-98.
1998: David S Franklin; Virginia L Godfrey; Hayyoung Lee; G I Kovalev; Robert Schoonhoven; Selina Chen-Kiang; Lishan Su; Yue Xiong
CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis.
Genes & development 1998;12(18):2899-911.
1998: DE Phelps; Yue Xiong
Regulation of cyclin-dependent kinase 4 during adipogenesis involves switching of cyclin D subunits and concurrent binding of p18INK4c and p27Kip1.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(8):595-610.
1998: Jennifer J Michel; Yue Xiong
Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(6):435-49.
1998: J Laliberté; A Yee; Yue Xiong; Beverly S Mitchell
Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes.
Blood 1998;91(8):2896-904.
1998: DE Phelps; K M Hsiao; Y Li; N Hu; David S Franklin; Eva Westphal; E Y Lee; Yue Xiong
Coupled transcriptional and translational control of cyclin-dependent kinase inhibitor p18INK4c expression during myogenesis.
Molecular and cellular biology 1998;18(4):2334-43.
1998: Yi Zhang; Yue Xiong; Wendell G Yarbrough
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
Cell 1998;92(6):725-34.
1998: T Ohta; K Okamoto; F Isohashi; K Shibata; M Fukuda; S Yamaguchi; Yue Xiong
T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21.
Cancer research 1998;58(6):1095-8.
1998: H Watanabe; Z Q Pan; N Schreiber-Agus; Ronald A DePinho; Jerard Hurwitz; Yue Xiong
Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1392-7.
1997: H Tahara; A P Smith; R D Gaz; Maimoona A Zariwala; Yue Xiong; A Arnold
Parathyroid tumor suppressor on 1p: analysis of the p18 cyclin-dependent kinase inhibitor gene as a candidate.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(9):1330-4.
1997: DE Phelps; Yue Xiong
Assay for activity of mammalian cyclin D-dependent kinases CDK4 and CDK6.
Methods in enzymology 1997;283():194-205.
1997: L Morse; D Chen; D Franklin; Yue Xiong; Selina Chen-Kiang
Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6.
Immunity 1997;6(1):47-56.
1996: A Gemma; Seiichi Takenoshita; K Hagiwara; A Okamoto; E A Spillare; M G McMemamin; S Perwez Hussain; K Forrester; Maimoona A Zariwala; Yue Xiong; Curtis C Harris
Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines.
International journal of cancer. Journal international du cancer 1996;68(5):605-11.
1996: D A Alcorta; Yue Xiong; D Phelps; G Hannon; D Beach; J Carl Barrett
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13742-7.
1996: Maimoona A Zariwala; Yue Xiong
Lack of mutation in the cyclin-dependent kinase inhibitor, p19INK4d, in tumor-derived cell lines and primary tumors.
Oncogene 1996;13(9):2033-8.
1996: D S Franklin; Yue Xiong
Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation.
Molecular biology of the cell 1996;7(10):1587-99.
1996: D R Mayrose; M A Nichols; Yue Xiong; Hengming Ke
Purification and crystallization of cyclin-dependent kinase inhibitor p21.
Protein science : a publication of the Protein Society 1996;5(9):1928-30.
1996: Yue Xiong
Why are there so many CDK inhibitors?
Biochimica et biophysica acta 1996;1288(1):01-5.
1996: C A Afshari; M A Nichols; Yue Xiong; maria mudryj
A role for a p21-E2F interaction during senescence arrest of normal human fibroblasts.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(8):979-88.
1996: Marek Rusin; A Okamoto; Mieczyslaw Chorazy; K Czyzewski; J Harasim; E A Spillare; K Hagiwara; S Perwez Hussain; Yue Xiong; D J Demetrick; Curtis C Harris
Intragenic mutations of the p16(INK4), p15(INK4B) and p18 genes in primary non-small-cell lung cancers.
International journal of cancer. Journal international du cancer 1996;65(6):734-9.
1996: H Wu; M Wade; L Krall; Joe W Grisham; Yue Xiong; Terry Van Dyke
Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.
Genes & development 1996;10(3):245-60.
1996: Yue Xiong; Dhandapani Kuppuswamy; Y Li; E M Livanos; Mary L Hixon; A White; D Beach; Thea D Tlsty
Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation.
Journal of virology 1996;70(2):999-1008.
1996: Maimoona A Zariwala; E Liu; Yue Xiong
Mutational analysis of the p16 family cyclin-dependent kinase inhibitors p15INK4b and p18INK4c in tumor-derived cell lines and primary tumors.
Oncogene 1996;12(2):451-5.
1996: A Yee; Lingtao Wu; L Liu; R Kobayashi; Yue Xiong; Frederick L Hall
Biochemical characterization of the human cyclin-dependent protein kinase activating kinase. Identification of p35 as a novel regulatory subunit.
The Journal of biological chemistry 1996;271(1):471-7.
1996: K L Guan; C W Jenkins; Y Li; C L O'Keefe; S Noh; X Wu; Maimoona A Zariwala; A Gregory Matera; Yue Xiong
Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.
Molecular biology of the cell 1996;7(1):57-70.
1995: A Yee; M A Nichols; L Wu; F L Hall; R Kobayashi; Yue Xiong
Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor.
Cancer research 1995;55(24):6058-62.
1995: JM Li; M A Nichols; S Chandrasekharan; Yue Xiong; Xiao-Fan Wang
Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site.
The Journal of biological chemistry 1995;270(45):26750-3.
1995: Prasad R K Koduru; Maimoona A Zariwala; M Soni; J Z Gong; Yue Xiong; J D Broome
Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma.
Blood 1995;86(8):2900-5.
1995: O Aprelikova; Yue Xiong; Edison Liu
Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.
The Journal of biological chemistry 1995;270(31):18195-7.
1995: Michael B Datto; Y Li; J F Panus; D J Howe; Yue Xiong; Xiao-Fan Wang
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5545-9.
1995: D J Demetrick; S Matsumoto; G J Hannon; K Okamoto; Yue Xiong; H Zhang; D H Beach
Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3).
Cytogenetics and cell genetics 1995;69(3-4):190-2.
1994: K L Guan; C W Jenkins; Y Li; M A Nichols; X Wu; C L O'Keefe; A Gregory Matera; Yue Xiong
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
Genes & development 1994;8(24):2939-52.
1994: Y Li; M A Nichols; J W Shay; Yue Xiong
Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.
Cancer research 1994;54(23):6078-82.
1994: Y Li; C W Jenkins; M A Nichols; Yue Xiong
Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21.
Oncogene 1994;9(8):2261-8.
1994: A Philipp; A Schneider; I Väsrik; K Finke; Yue Xiong; D Beach; K Alitalo; Martin Eilers
Repression of cyclin D1: a novel function of MYC.
Molecular and cellular biology 1994;14(6):4032-43.
1993: Yue Xiong; G J Hannon; H Zhang; D Casso; Ryuji Kobayashi; D Beach
p21 is a universal inhibitor of cyclin kinases.
Nature 1993;366(6456):701-4.
1993: H Zhang; Yue Xiong; D Beach
Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.
Molecular biology of the cell 1993;4(9):897-906.
1993: Yue Xiong; H Zhang; D Beach
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.
Genes & development 1993;7(8):1572-83.
1993: Yue Xiong; William D Burke; Thomas H Eickbush
Pao, a highly divergent retrotransposable element from Bombyx mori containing long terminal repeats with tandem copies of the putative R region.
Nucleic acids research 1993;21(9):2117-23.
1993: Yue Xiong; Thomas H Eickbush
Dong, a non-long terminal repeat (non-LTR) retrotransposable element from Bombyx mori.
Nucleic acids research 1993;21(5):1318.
1993: William D Burke; D G Eickbush; Yue Xiong; J Jakubczak; Thomas H Eickbush
Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species.
Molecular biology and evolution 1993;10(1):163-85.
1992: Yue Xiong; H Zhang; D Beach
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA.
Cell 1992;71(3):505-14.
1992: K A Won; Yue Xiong; D Beach; M Gilman
Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9910-4.
1992: Yue Xiong; J Menninger; D Beach; D C Ward
Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.
Genomics 1992;13(3):575-84.
1991: Yue Xiong; T Connolly; Bruce Futcher; D Beach
Human D-type cyclin.
Cell 1991;65(4):691-9.
1990: Yue Xiong; T H Eickbush
Origin and evolution of retroelements based upon their reverse transcriptase sequences.
The EMBO journal 1990;9(10):3353-62.
1990: J L Jakubczak; Yue Xiong; Thomas H Eickbush
Type I (R1) and type II (R2) ribosomal DNA insertions of Drosophila melanogaster are retrotransposable elements closely related to those of Bombyx mori.
Journal of molecular biology 1990;212(1):37-52.
1988: Yue Xiong; William D Burke; J L Jakubczak; Thomas H Eickbush
Ribosomal DNA insertion elements R1Bm and R2Bm can transpose in a sequence specific manner to locations outside the 28S genes.
Nucleic acids research 1988;16(22):10561-73.
1988: Yue Xiong; Thomas H Eickbush
Similarity of reverse transcriptase-like sequences of viruses, transposable elements, and mitochondrial introns.
Molecular biology and evolution 1988;5(6):675-90.
1988: Yue Xiong; T H Eickbush
The site-specific ribosomal DNA insertion element R1Bm belongs to a class of non-long-terminal-repeat retrotransposons.
Molecular and cellular biology 1988;8(1):114-23.