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William Breuer

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Yang-Sung Sohn; Guenter Weiss; Samah Attar; William Breuer; hussam ghoti; Eliezer Rachmilewitz; Z Ioav Cabantchik
The role of endocytic pathways in cellular uptake of plasma non-transferrin iron.
Yang-Sung Sohn; Guenter Weiss; William Breuer; Anna-Maria Mitterstiller; Z Ioav Cabantchik
Rescuing iron-overloaded macrophages by conservative relocation of the accumulated metal.
Or Kakhlon; William Breuer; Arnold Munnich; Ioav Cabantchik
Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulation.

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All Publications

2012: Yang-Sung Sohn; Guenter Weiss; Samah Attar; William Breuer; hussam ghoti; Eliezer Rachmilewitz; Z Ioav Cabantchik
The role of endocytic pathways in cellular uptake of plasma non-transferrin iron.
Haematologica 2012;97(5):670-8.
2011: Yang-Sung Sohn; Guenter Weiss; William Breuer; Anna-Maria Mitterstiller; Z Ioav Cabantchik
Rescuing iron-overloaded macrophages by conservative relocation of the accumulated metal.
British journal of pharmacology 2011;164(2b):406-18.
2010: Or Kakhlon; William Breuer; Arnold Munnich; Ioav Cabantchik
Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulation.
Canadian journal of physiology and pharmacology 2010;88(3):187-96.
2009: Giuliana Zanninelli; William Breuer; Ioav Cabantchik
Daily labile plasma iron as an indicator of chelator activity in Thalassaemia major patients.
British journal of haematology 2009;147(5):744-51.
2008: Or Kakhlon; Hila Manning; William Breuer; Naomi Melamed-Book; Chunye Lu; Gino Cortopassi; Arnold Munnich; Ioav Cabantchik
Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation.
Blood 2008;112(13):5219-27.
2008: Yang-Sung Sohn; William Breuer; Arnold Munnich; Ioav Cabantchik
Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications.
Blood 2008;111(3):1690-9.
2008: William Breuer; Maya Shvartsman; Ioav Cabantchik
Intracellular labile iron.
The international journal of biochemistry & cell biology 2008;40(3):350-4.
2007: Sara Gardenghi; maria franca marongiu; Pedro Ramos; Ella Guy; Laura Breda; Amy Chadburn; YiFang Liu; Ninette Amariglio; Gideon Rechavi; Eliezer A Rachmilewitz; William Breuer; Ioav Cabantchik; Diedra M Wrighting; Nancy C Andrews; Maria de Sousa; Patricia J Giardina; Robert W Grady; Stefano Rivella
Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.
Blood 2007;109(11):5027-35.
2006: Hava Glickstein; Rinat Ben El; Gabriela Link; William Breuer; Abraham M Konijn; Chaim Hershko; Hanspeter Nick; Ioav Cabantchik
Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences.
Blood 2006;108(9):3195-203.
2006: Orly Weizer-Stern; Konstantin Adamsky; Ninette Amariglio; Carina Levin; Ariel Koren; William Breuer; Eliezer A Rachmilewitz; Laura Breda; Stefano Rivella; Ioav Cabantchik; Gideon Rechavi
Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera.
British journal of haematology 2006;135(1):129-38.
2006: Daphne L van der A; Joannes Marx; Diederick Grobbee; Marjolein H Kamphuis; Niki A Georgiou; J Henny van Kats-Renaud; William Breuer; Ioav Cabantchik; Mark Roest; Hieronymus A M Voorbij; Yvonne van der Schouw
Non-transferrin-bound iron and risk of coronary heart disease in postmenopausal women.
Circulation 2006;113(16):1942-9.
2005: E M G Jacobs; Jan C M Hendriks; Berry L J H van Tits; Patricia J Evans; William Breuer; Ding Yong Liu; Eugene H J M Jansen; Katri Jauhiainen; Brigitte Sturm; John B Porter; Barbara Scheiber-Mojdehkar; Leni von Bonsdorff; Ioav Cabantchik; Robert C Hider; Dorine W Swinkels
Results of an international round robin for the quantification of serum non-transferrin-bound iron: Need for defining standardization and a clinically relevant isoform.
Analytical biochemistry 2005;341(2):241-50.
2005: Ioav Cabantchik; William Breuer; Giuliana Zanninelli; Paolo Cianciulli
LPI-labile plasma iron in iron overload.
Best practice & research. Clinical haematology 2005;18(2):277-87.
2005: Caroline Le Lan; Olivier Loréal; Tally Cohen; Martine Ropert; Hava Glickstein; Fabrice Lainé; Michel Pouchard; Yves Deugnier; André LE TREUT; William Breuer; Ioav Cabantchik; Pierre Brissot
Redox active plasma iron in C282Y/C282Y hemochromatosis.
Blood 2005;105(11):4527-31.
2004: Mahmoud Sulieman; Rabea Asleh; Zvi I Cabantchik; William Breuer; Doron Aronson; Abeer Suleiman; Rachel Miller-Lotan; Haim Hammerman; Andrew P Levy
Serum chelatable redox-active iron is an independent predictor of mortality after myocardial infarction in individuals with diabetes.
Diabetes care 2004;27(11):2730-2.
2004: Pensri Pootrakul; William Breuer; Matias Sametband; Pornpan Sirankapracha; Chaim Hershko; Ioav Cabantchik
Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia/HbE patients treated with an oral chelator.
Blood 2004;104(5):1504-10.
2004: Anat Gafter-Gvili; Miron Prokocimer; William Breuer; Ioav Zeev Cabantchik; Chaim Hershko
Non-transferrin-bound serum iron (NTBI) in megaloblastic anemia: effect of vitamin B(12) treatment.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5(1):32-4.
2003: Breno P Esposito; William Breuer; Pornpan Sirankapracha; Pensri Pootrakul; Chaim Hershko; Ioav Cabantchik
Labile plasma iron in iron overload: redox activity and susceptibility to chelation.
Blood 2003;102(7):2670-7.
2003: Gabriela Link; Prem Ponka; Abraham M Konijn; William Breuer; Ioav Cabantchik; Chaim Hershko
Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells.
Blood 2003;101(10):4172-9.
2003: Chaim Hershko; Aya Abrahamov; Abraham M Konijn; William Breuer; Ioav Zeev Cabantchik; Pensri Pootrakul; Gabriela Link
Objectives and methods of iron chelation therapy.
Bioinorganic chemistry and applications 2003;():151-68.
2002: Breno P Espósito; William Breuer; Ioav Cabantchik
Design and applications of methods for fluorescence detection of iron in biological systems.
Biochemical Society transactions 2002;30(4):729-32.
2002: Breno P Espósito; Silvina Epsztejn; William Breuer; Ioav Cabantchik
A review of fluorescence methods for assessing labile iron in cells and biological fluids.
Analytical biochemistry 2002;304(1):1-18.
2002: Breno P Espósito; William Breuer; Itzchak Slotki; Ioav Cabantchik
Labile iron in parenteral iron formulations and its potential for generating plasma nontransferrin-bound iron in dialysis patients.
European journal of clinical investigation 2002;32 Suppl 1():42-9.
2002: Ioav Cabantchik; Or Kakhlon; Silvina Epsztejn; Giuliana Zanninelli; William Breuer
Intracellular and extracellular labile iron pools.
Advances in experimental medicine and biology 2002;509():55-75.
2002: Anat Gafter-Gvili; Miron Prokocimer; William Breuer; Ioav Zeev Cabantchik; Chaim Hershko
Increased non-transferrin-bound serum iron in megaloblastic anaemia.
Acta haematologica 2002;108(1):53-4.
2001: William Breuer; Ioav Cabantchik
A fluorescence-based one-step assay for serum non-transferrin-bound iron.
Analytical biochemistry 2001;299(2):194-202.
2001: Gabriela Link; Abraham M Konijn; William Breuer; Ioav Cabantchik; Chaim Hershko
Exploring the "iron shuttle" hypothesis in chelation therapy: effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture.
The Journal of laboratory and clinical medicine 2001;138(2):130-8.
2001: Chaim Hershko; Abraham M Konijn; H P Nick; William Breuer; Ioav Cabantchik; Gabriela Link
ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture.
Blood 2001;97(4):1115-22.
2001: William Breuer; M J Ermers; Pensri Pootrakul; A Abramov; Chaim Hershko; Ioav Cabantchik
Desferrioxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy.
Blood 2001;97(3):792-8.
2000: William Breuer; M J Ermers; Pensri Pootrakul; A Abramov; Chaim Hershko; Ioav Cabantchik
Desferrioxamine-chelatable iron (DCI), a component of serum non-transferrin-bound iron (NTBI) used for assessing iron chelation therapy.
Transfusion science 2000;23(3):241-2.
2000: William Breuer; Chaim Hershko; Ioav Cabantchik
The importance of non-transferrin bound iron in disorders of iron metabolism.
Transfusion science 2000;23(3):185-92.
2000: William Breuer; Aharon Ronson; Itzchak Slotki; A Abramov; Chaim Hershko; Ioav Cabantchik
The assessment of serum nontransferrin-bound iron in chelation therapy and iron supplementation.
Blood 2000;95(9):2975-82.
1999: Silvina Epsztejn; Hava Glickstein; Virginie Picard; Itzchak Slotki; William Breuer; C Beaumont; Ioav Cabantchik
H-ferritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance properties.
Blood 1999;94(10):3593-603.
1997: Silvina Epsztejn; Or Kakhlon; Hava Glickstein; William Breuer; Ioav Zeev Cabantchik
Fluorescence analysis of the labile iron pool of mammalian cells.
Analytical biochemistry 1997;248(1):31-40.
1997: Giuliana Zanninelli; Hava Glickstein; William Breuer; P Milgram; Pierre Brissot; Robert C Hider; Abraham M Konijn; J Libman; Abraham Shanzer; Ioav Cabantchik
Chelation and mobilization of cellular iron by different classes of chelators.
Molecular pharmacology 1997;51(5):842-52.
1997: William Breuer; E Greenberg; Ioav Cabantchik
Newly delivered transferrin iron and oxidative cell injury.
FEBS letters 1997;403(2):213-9.
1996: Hava Glickstein; William Breuer; M Loyevsky; Abraham M Konijn; Abraham Shanzer; Ioav Cabantchik
Differential cytotoxicity of iron chelators on malaria-infected cells versus mammalian cells.
Blood 1996;87(11):4871-8.
1996: William Breuer; Silvina Epsztejn; Ioav Cabantchik
Dynamics of the cytosolic chelatable iron pool of K562 cells.
FEBS letters 1996;382(3):304-8.
1996: Ioav Cabantchik; Hava Glickstein; P Milgram; William Breuer
A fluorescence assay for assessing chelation of intracellular iron in a membrane model system and in mammalian cells.
Analytical biochemistry 1996;233(2):221-7.
1995: William Breuer; Silvina Epsztejn; Ioav Cabantchik
Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II).
The Journal of biological chemistry 1995;270(41):24209-15.
1995: William Breuer; Silvina Epsztejn; P Millgram; Ioav Zeev Cabantchik
Transport of iron and other transition metals into cells as revealed by a fluorescent probe.
The American journal of physiology 1995;268(6 Pt 1):C1354-61.
1993: William Breuer; Itzchak Slotki; D A Ausiello; Ioav Zeev Cabantchik
Induction of multidrug resistance downregulates the expression of CFTR in colon epithelial cells.
The American journal of physiology 1993;265(6 Pt 1):C1711-5.
1993: William Breuer; Hava Glickstein; Norbert Kartner; John R Riordan; D A Ausiello; Ioav Zeev Cabantchik
Protein kinase C mediates down-regulation of cystic fibrosis transmembrane conductance regulator levels in epithelial cells.
The Journal of biological chemistry 1993;268(19):13935-9.
1993: Itzchak Slotki; William Breuer; Rainer Greger; Ioav Cabantchik
Long-term cAMP activation of Na(+)-K(+)-2Cl- cotransporter activity in HT-29 human adenocarcinoma cells.
The American journal of physiology 1993;264(4 Pt 1):C857-65.
1992: William Breuer; Norbert Kartner; John R Riordan; Ioav Cabantchik
Induction of expression of the cystic fibrosis transmembrane conductance regulator.
The Journal of biological chemistry 1992;267(15):10465-9.