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Cor Breukel

Research Profile

Disorders

Anatomy

Chromosomes, Human, Pair 5

Genes & Molecular Sequences

APC Genes

Chemicals & Drugs

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A Seda Yılmaz-Eliş; Aartsma-Rus Annemieke; Cor Breukel; Sjef De Kimpe; Huma Safdar; Peter Ac 't Hoen; Judith C T van Deutekom; Gert-Jan van Ommen; Bart J M van Vlijmen; Sjef Verbeek
Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP).
Peter I Boross; Marina Botto; Cor Breukel; Marcel Camps; Francesco Carlucci; Jill W C Claassens; H Terence Cook; Mohamed R Daha; Roelof Flierman; Shozo Izui; Erik Lubberts; Javier Martin-Ramirez; Ferry Ossendorp; Maria Pia Rastaldi; Daniela Salvatori; Marie-Laure Santiago-Raber; Jos van der Kaa; Victoria L Arandhara; Sjef Verbeek
The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility.
Els C Robanus-Maandag; Pim J Koelink; Cor Breukel; Daniela C F Salvatori; Shantie C Jagmohan-Changur; Cathy A J Bosch; Hein Verspaget; Peter Devilee; Riccardo Fodde; Ron Smits
A new conditional Apc-mutant mouse model for colorectal cancer.

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All Publications

2013: A Seda Yılmaz-Eliş; Aartsma-Rus Annemieke; Cor Breukel; Sjef De Kimpe; Huma Safdar; Peter Ac 't Hoen; Judith C T van Deutekom; Gert-Jan van Ommen; Bart J M van Vlijmen; Sjef Verbeek
Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP).
Molecular therapy. Nucleic acids 2013;2():e66.
2011: Peter I Boross; Marina Botto; Cor Breukel; Marcel Camps; Francesco Carlucci; Jill W C Claassens; H Terence Cook; Mohamed R Daha; Roelof Flierman; Shozo Izui; Erik Lubberts; Javier Martin-Ramirez; Ferry Ossendorp; Maria Pia Rastaldi; Daniela Salvatori; Marie-Laure Santiago-Raber; Jos van der Kaa; Victoria L Arandhara; Sjef Verbeek
The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1304-13.
2010: Els C Robanus-Maandag; Pim J Koelink; Cor Breukel; Daniela C F Salvatori; Shantie C Jagmohan-Changur; Cathy A J Bosch; Hein Verspaget; Peter Devilee; Riccardo Fodde; Ron Smits
A new conditional Apc-mutant mouse model for colorectal cancer.
Carcinogenesis 2010;31(5):946-52.
2009: Peter Boross; Cor Breukel; Pieter Fokko Van Loo; Jos van der Kaa; Jill W Claassens; Hermann Bujard; Kai Schönig; Sjef Verbeek
Highly B lymphocyte-specific tamoxifen inducible transgene expression of CreER T2 by using the LC-1 locus BAC vector.
Genesis (New York, N.Y. : 2000) 2009;47(11):729-35.
2009: Claudia Gaspar; Patrick Franken; Lia Molenaar; Cor Breukel; Martin van der Valk; Ron Smits; Riccardo Fodde
A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.
PLoS genetics 2009;5(7):e1000547.
2006: Klaus-Peter Janssen; Paola Alberici; Hafida Fsihi; Claudia Gaspar; Cor Breukel; Patrick Franken; Christophe Rosty; Miguel Abal; Fatima el-Marjou; Ron Smits; Daniel Louvard; Riccardo Fodde; Sylvie Robine
APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression.
Gastroenterology 2006;131(4):1096-109.
2003: Anja Wagner; Alicia Barrows; Juul Wijnen; Heleen van der Klift; Patrick F Franken; Paul Verkuijlen; Hidewaki Nakagawa; Marjan Geugien; Shantie Jaghmohan-Changur; Cor Breukel; Hanne Meijers-Heijboer; Hans Morreau; Marjo Van Puijenbroek; John Burn; Stephanie M Coronel; Yulia Kinarski; Ross Okimoto; Patrice Watson; Jane F Lynch; Albert de La Chapelle; Henry T Lynch; Riccardo Fodde
Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene.
American journal of human genetics 2003;72(5):1088-100.
2002: Menno F Kielman; Maaret Rindapää; Claudia Gaspar; Nicole van Poppel; Cor Breukel; Steven H van Leeuwen; Makoto M Taketo; Scott Roberts; Ron Smits; Riccardo Fodde
Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling.
Nature genetics 2002;32(4):594-605.
2002: Anja Wagner; Heleen van der Klift; Patrick Franken; Juul Wijnen; Cor Breukel; Vladimir Bezrookove; Ron Smits; Yulia Kinarsky; Alicia Barrows; Barbara Franklin; Jane Lynch; Henry T Lynch; Riccardo Fodde
A 10-Mb paracentric inversion of chromosome arm 2p inactivates MSH2 and is responsible for hereditary nonpolyposis colorectal cancer in a North-American kindred.
Genes, chromosomes & cancer 2002;35(1):49-57.
2002: Cristina Albuquerque; Cor Breukel; Rob B van der Luijt; Paulo Fidalgo; Pedro Lage; Frederik J M Slors; C Nobre Leitão; Riccardo Fodde; Ron Smits
The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.
Human molecular genetics 2002;11(13):1549-60.
2001: Peter Hohenstein; Menno F Kielman; Cor Breukel; L M Bennett; R Wiseman; Paul Krimpenfort; Cees J Cornelisse; Gert-Jan B van Ommen; Peter Devilee; Riccardo Fodde
A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage.
Oncogene 2001;20(20):2544-50.
2001: Riccardo Fodde; J Kuipers; Carla Rosenberg; Ron Smits; Menno F Kielman; Claudia Gaspar; Johan H van Es; Cor Breukel; Joop Wiegant; Rachel H Giles; Hans Clevers
Mutations in the APC tumour suppressor gene cause chromosomal instability.
Nature cell biology 2001;3(4):433-8.
2000: Ron Smits; N Hofland; Winfried Edelmann; Marjan Geugien; Shantie Jagmohan-Changur; Cristina Albuquerque; Cor Breukel; Raju Kucherlapati; Menno F Kielman; Riccardo Fodde
Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity.
Genes, chromosomes & cancer 2000;29(3):229-39.
2000: Ron Smits; P Ruiz; Salvador J. Diaz-Cano; A Luz; Shantie Jagmohan-Changur; Cor Breukel; C Birchmeier; W Birchmeier; Riccardo Fodde
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice.
Gastroenterology 2000;119(4):1045-53.
1999: George A Calin; Juul Wijnen; Heleen van der Klift; A Ionita; A Mulder; Cor Breukel; Ron Smits; H Dauwerse; K Hansson; S Calin; D Stefanescu; Alexandru Oproiu; Riccardo Fodde
Marfan-like habitus and familial adenomatous polyposis in two unrelated males: a significant association?
European journal of human genetics : EJHG 1999;7(5):609-14.
1999: Ron Smits; Menno F Kielman; Cor Breukel; Chris Zurcher; K Neufeld; Shantie Jagmohan-Changur; N Hofland; J van Dijk; Raymond White; Winfried Edelmann; Raju Kucherlapati; PM Khan; Riccardo Fodde
Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development.
Genes & development 1999;13(10):1309-21.
1999: Alex Kartheuser; C Walon; S West; Cor Breukel; Roger Detry; A C Gribomont; T Hamzehloei; P Hoang; D Maiter; JH Pringot; J Rahier; PM Khan; A Curtis; John Burn; Riccardo Fodde; Christine Verellen-Dumoulin
Familial adenomatous polyposis associated with multiple adrenal adenomas in a patient with a rare 3' APC mutation.
Journal of medical genetics 1999;36(1):65-7.
1998: Ron Smits; W van der Houven van Oordt; A Luz; Chris Zurcher; Shantie Jagmohan-Changur; Cor Breukel; PM Khan; Riccardo Fodde
Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts.
Gastroenterology 1998;114(2):275-83.
1997: Ron Smits; Alex Kartheuser; Shantie Jagmohan-Changur; V Leblanc; Cor Breukel; A de Vries; Henk J van Kranen; J H J M van Krieken; S Williamson; Winfried Edelmann; Raju Kucherlapati; Riccardo Fodde
Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.
Carcinogenesis 1997;18(2):321-7.
1996: D M Eccles; R van der Luijt; Cor Breukel; H Bullman; D Bunyan; A Fisher; J Barber; C du Boulay; John Primrose; J Burn; Riccardo Fodde
Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene.
American journal of human genetics 1996;59(6):1193-201.
1996: R B van der Luijt; P Meera Khan; H F A Vasen; Cor Breukel; Carli Tops; R J Scott; Riccardo Fodde
Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli.
Human genetics 1996;98(6):727-34.
1995: R B van der Luijt; H F A Vasen; Carli Tops; Cor Breukel; Riccardo Fodde; P Meera Khan
APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis.
Human genetics 1995;96(6):705-10.
1995: R B van der Luijt; Carli Tops; PM Khan; Heleen van der Klift; Cor Breukel; I S van Leeuwen-Cornelisse; Hans Dauwerse; Geoffrey C Beverstock; E van Noort; P Snel
Molecular, cytogenetic, and phenotypic studies of a constitutional reciprocal translocation t(5;10)(q22;q25) responsible for familial adenomatous polyposis in a Dutch pedigree.
Genes, chromosomes & cancer 1995;13(3):192-202.
1994: Riccardo Fodde; Winfried Edelmann; K Yang; C van Leeuwen; C Carlson; B Renault; Cor Breukel; E Alt; Martin Lipkin; PM Khan
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):8969-73.
1992: Carli Tops; H F A Vasen; G van Berge Henegouwen; P P Simoons; H M van de Klift; S J van Leeuwen; Cor Breukel; Riccardo Fodde; F C den Hartog Jager; F M Nagengast
Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis.
American journal of medical genetics 1992;43(5):888-93.
1991: Juul Wijnen; Carli Tops; Cor Breukel; C van Leeuwen; A Goverde; Heleen van der Klift; Riccardo Fodde; PM Khan
CA repeat polymorphism from YAC JW25 at the D5S318 locus, distal to adenomatous polyposis coli (APC).
Nucleic acids research 1991;19(24):6965.
1991: Cor Breukel; Carli Tops; C van Leeuwen; Heleen van der Klift; Riccardo Fodde; PM Khan
AT repeat polymorphism at the D5S122 locus tightly linked to adenomatous polyposis coli (APC).
Nucleic acids research 1991;19(23):6665.
1991: C van Leeuwen; Carli Tops; Cor Breukel; Heleen van der Klift; L Deaven; Riccardo Fodde; PM Khan
CA repeat polymorphism within the MCC (mutated in colorectal cancer) gene.
Nucleic acids research 1991;19(20):5805.
1991: Cor Breukel; Carli Tops; C van Leeuwen; Heleen van der Klift; Y Nakamura; Riccardo Fodde; PM Khan
CA repeat polymorphism at the D5S82 locus, proximal to adenomatous polyposis coli (APC).
Nucleic acids research 1991;19(20):5804.
1991: C van Leeuwen; Carli Tops; Cor Breukel; Heleen van der Klift; Riccardo Fodde; PM Khan
CA repeat polymorphism at the D5S299 locus linked to adenomatous polyposis coli (APC).
Nucleic acids research 1991;19(20):5805.
1991: Cor Breukel; Carli Tops; E Ras; PM Khan
Mspl RFLP at the D5S122 locus tightly linked to APC.
Nucleic acids research 1991;19(3):685.
1991: Carli Tops; Cor Breukel; Heleen van der Klift; I S von Leeuwen; Juul Wijnen; Gerrit Griffioen; H F A Vasen; F C den Hartog Jager; F M Nagengast; Cornelis B H W Lamers
A new deletion polymorphism at D5S71 raises the linkage information on adenomatous polyposis coli: implications for presymptomatic diagnosis.
Human genetics 1991;86(4):365-8.
1990: Cor Breukel; Juul Wijnen; Carli Tops; H vd Klift; Hans Dauwerse; PM Khan
Vector-Alu PCR: a rapid step in mapping cosmids and YACs.
Nucleic acids research 1990;18(10):3097.
1989: Cor Breukel; Carli Tops; PM Khan
Four-base-pair deletion polymorphism at D5S71 (C11p11) linked to APC in the human chromosome 5q21-q22 region.
Nucleic acids research 1989;17(24):10512.
1989: Carli Tops; Juul Wijnen; Gerrit Griffioen; I S von Leeuwen; H F A Vasen; F C den Hartog Jager; Cor Breukel; F M Nagengast; Heleen van der Klift; Cornelis B H W Lamers
Presymptomatic diagnosis of familial adenomatous polyposis by bridging DNA markers.
Lancet 1989;2(8676):1361-3.
1989: Suresh C Jhanwar; T M Berkvens; Cor Breukel; Hans van Ormondt; Alex J van der Eb; P Meera Khan
Localization of human adenosine deaminase (ADA) gene sequences to the q12----q13.11 region of chromosome 20 by in situ hybridization.
Cytogenetics and cell genetics 1989;50(2-3):168-71.
1988: P Meera Khan; Carli Tops; M vd Broek; Cor Breukel; Juul Wijnen; M Oldenburg; J vd Bos; I S van Leeuwen-Cornelisse; H F A Vasen; Gerrit Griffioen
Close linkage of a highly polymorphic marker (D5S37) to familial adenomatous polyposis (FAP) and confirmation of FAP localization on chromosome 5q21-q22.
Human genetics 1988;79(2):183-5.
1987: T M Berkvens; E J Gerritsen; M Oldenburg; Cor Breukel; Juul Wijnen; Hans van Ormondt; Jaak M Vossen; Alex J van der Eb; P Meera Khan
Severe combined immune deficiency due to a homozygous 3.2-kb deletion spanning the promoter and first exon of the adenosine deaminase gene.
Nucleic acids research 1987;15(22):9365-78.
1986: T M Berkvens; D Valerio; M G Duyvesteyn; B M Dekker; G Weeda; L van der Voorn; Cor Breukel; Hans van Ormondt; PM Khan; Alex J van der Eb
The human gene for adenosine deaminase.
Advances in experimental medicine and biology 1986;195 Pt A():211-6.