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Eefjan Breukink

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Aline Dias Paiva; Maria Cristina Baracat-Pereira; Eefjan Breukink; Michelle Dias de Oliveira; Sérgio Oliveira De Paula; Hilário C Mantovani
Toxicity of bovicin HC5 against mammalian cell lines and the role of cholesterol in bacteriocin activity.
Monique P C Mulder; Adriaan J Minnaard; Eefjan Breukink; Peter Fodran; Johan Kemmink; John A W Kruijtzer; Rob M J Liskamp
Mutual influence of backbone proline substitution and lipophilic tail character on the biological activity of simplified analogues of caspofungin.
Aline Dias Paiva; Eefjan Breukink; Nicole Irving; Hilário C Mantovani
Interaction with lipid II induces conformational changes in bovicin HC5 structure.

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2012: Aline Dias Paiva; Maria Cristina Baracat-Pereira; Eefjan Breukink; Michelle Dias de Oliveira; Sérgio Oliveira De Paula; Hilário C Mantovani
Toxicity of bovicin HC5 against mammalian cell lines and the role of cholesterol in bacteriocin activity.
Microbiology (Reading, England) 2012;158(Pt 11):2851-8.
2012: Monique P C Mulder; Adriaan J Minnaard; Eefjan Breukink; Peter Fodran; Johan Kemmink; John A W Kruijtzer; Rob M J Liskamp
Mutual influence of backbone proline substitution and lipophilic tail character on the biological activity of simplified analogues of caspofungin.
Organic & biomolecular chemistry 2012;10(37):7491-502.
2012: Aline Dias Paiva; Eefjan Breukink; Nicole Irving; Hilário C Mantovani
Interaction with lipid II induces conformational changes in bovicin HC5 structure.
Antimicrobial agents and chemotherapy 2012;56(9):4586-93.
2012: Cristina Chamorro; Christopher J Arnusch; Marcel A Boerman; Eefjan Breukink; Roland J Pieters
Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides.
Biochimica et biophysica acta 2012;1818(9):2171-4.
2012: Yvonne Maria te Welscher; Martin Richard van Leeuwen; Ben de Kruijff; Jan Dijksterhuis; Eefjan Breukink
Polyene antibiotic that inhibits membrane transport proteins.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(28):11156-9.
2012: Manuel Banzhaf; Eefjan Breukink; Tanneke den Blaauwen; Alexander Egan; Claudine Fraipont; Martine Nguyen-Distèche; Jules Philippe; Mohammed Terrak; Bart van den Berg van Saparoea; André Zapun; Waldemar Vollmer
Cooperativity of peptidoglycan synthases active in bacterial cell elongation.
Molecular microbiology 2012;85(1):179-94.
2012: Nordine Helassa; Thierry Vernet; Waldemar Vollmer; Eefjan Breukink; André Zapun
The membrane anchor of penicillin-binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length.
The FEBS journal 2012;279(11):2071-81.
2012: Ioulia Nikolaidis; Nicole THIELENS; Eefjan Breukink; Thierry Izoré; Viviana Job; Andréa Dessen
Calcium-dependent complex formation between PBP2 and lytic transglycosylase SltB1 of Pseudomonas aeruginosa.
Microbial drug resistance (Larchmont, N.Y.) 2012;18(3):298-305.
2012: Marjolein van der Kaaden; Eefjan Breukink; Roland J Pieters
Synthesis and antifungal properties of papulacandin derivatives.
Beilstein journal of organic chemistry 2012;8():732-7.
2012: Christopher J Arnusch; Roland J Pieters; Eefjan Breukink
Enhanced membrane pore formation through high-affinity targeted antimicrobial peptides.
PloS one 2012;7(6):e39768.
2011: Monique P C Mulder; Roland J Pieters; Eefjan Breukink; Johan Kemmink; John A W Kruijtzer; Rob M J Liskamp
Synthesis and evaluation of novel macrocyclic antifungal peptides.
Bioorganic & medicinal chemistry 2011;19(21):6505-17.
2011: Aline Dias Paiva; Eefjan Breukink; Hilário C Mantovani
Role of lipid II and membrane thickness in the mechanism of action of the lantibiotic bovicin HC5.
Antimicrobial agents and chemotherapy 2011;55(11):5284-93.
2011: J J Wijnker; E A W S Weerts; Eefjan Breukink; J H Houben; L J A Lipman
Reduction of Clostridium sporogenes spore outgrowth in natural sausage casings using nisin.
Food microbiology 2011;28(5):974-9.
2011: Nick K Olrichs; Mirjam E G Aarsman; Jolanda Verheul; Christopher J Arnusch; Nathaniel I Martin; Mireille Hervé; Waldemar Vollmer; Ben de Kruijff; Eefjan Breukink; Tanneke den Blaauwen
A novel in vivo cell-wall labeling approach sheds new light on peptidoglycan synthesis in Escherichia coli.
Chembiochem : a European journal of chemical biology 2011;12(7):1124-33.
2011: Adeline Derouaux; Samo Turk; Nick K Olrichs; Stanislav Gobec; Eefjan Breukink; Ana Amoroso; Julien Offant; Julieanne Bostock; Katherine Mariner; Ian Chopra; Thierry Vernet; Astrid Zervosen; Bernard Joris; Jean-Marie Frère; Martine Nguyen-Distèche; Mohammed Terrak
Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor.
Biochemical pharmacology 2011;81(9):1098-105.
2011: Tamimount Mohammadi; Vincent van Dam; Robert Sijbrandi; Thierry Vernet; André Zapun; Ahmed Bouhss; Marlies Diepeveen-de Bruin; Martine Nguyen-Distèche; Ben de Kruijff; Eefjan Breukink
Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane.
The EMBO journal 2011;30(8):1425-32.
2010: Athanasios Typas; Manuel Banzhaf; Bart van den Berg van Saparoea; Jolanda Verheul; Jacob Biboy; Robert J Nichols; Matylda Zietek; Katrin Beilharz; Kai Kannenberg; Moritz von Rechenberg; Eefjan Breukink; Tanneke den Blaauwen; Carol A Gross; Waldemar Vollmer
Regulation of peptidoglycan synthesis by outer-membrane proteins.
Cell 2010;143(7):1097-109.
2010: Julien Offant; Mohammed Terrak; Adeline Derouaux; Eefjan Breukink; Martine Nguyen-Distèche; André Zapun; Thierry Vernet
Optimization of conditions for the glycosyltransferase activity of penicillin-binding protein 1a from Thermotoga maritima.
The FEBS journal 2010;277(20):4290-8.
2010: Yvonne Maria te Welscher; Lynden Jones; Martin Richard van Leeuwen; Jan Dijksterhuis; Ben de Kruijff; Gary Eitzen; Eefjan Breukink
Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol.
Antimicrobial agents and chemotherapy 2010;54(6):2618-25.
2010: Erik de Leeuw; Changqing Li; Pengyun Zeng; Changqing Li; Marlies Diepeveen-de Buin; Wuyuan Lu; Eefjan Breukink; Wuyuan Lu
Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II.
FEBS letters 2010;584(8):1543-8.
2009: Eefjan Breukink
Cell biology. Lethal traffic jam.
Science (New York, N.Y.) 2009;325(5941):684-5.
2009: H Bauke Albada; Christopher J Arnusch; Hilbert M Branderhorst; Anne-Marie Verel; Wouter T M Janssen; Eefjan Breukink; Ben de Kruijff; Roland J Pieters; Rob M J Liskamp
Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions.
Bioorganic & medicinal chemistry letters 2009;19(14):3721-4.
2009: Vincent van Dam; Nick Olrichs; Eefjan Breukink
Specific labeling of peptidoglycan precursors as a tool for bacterial cell wall studies.
Chembiochem : a European journal of chemical biology 2009;10(4):617-24.
2009: Maria Strianese; Gerhild Zauner; Armand W J W Tepper; Luigi Bubacco; Eefjan Breukink; Thijs J Aartsma; Gerard W Canters; Leandro C Tabares
A protein-based oxygen biosensor for high-throughput monitoring of cell growth and cell viability.
Analytical biochemistry 2009;385(2):242-8.
2009: Roland J Pieters; Christopher J Arnusch; Eefjan Breukink
Membrane permeabilization by multivalent anti-microbial peptides.
Protein and peptide letters 2009;16(7):736-42.
2009: Rianne A G Harmsen; Nourdin Ghalit; Johan Kemmink; Hans W Hilbers; Eefjan Breukink; Dirk T S Rijkers; Rob M J Liskamp
Alkene/alkane-bridged mimics of the lantibiotic nisin: toward novel peptide-based antibiotics.
Advances in experimental medicine and biology 2009;611():533-4.
2008: Christopher J Arnusch; Alexandre Bonvin; Anne Marie Verel; Wouter Jansen; Rob M J Liskamp; Ben de Kruijff; Roland J Pieters; Eefjan Breukink
The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant Enterococci.
Biochemistry 2008;47(48):12661-3.
2008: Mohammed Terrak; Eric Sauvage; Adeline Derouaux; Dominique Dehareng; Ahmed Bouhss; Eefjan Breukink; Sylvie Jeanjean; Martine Nguyen-Distèche
Importance of the conserved residues in the peptidoglycan glycosyltransferase module of the class A penicillin-binding protein 1b of Escherichia coli.
The Journal of biological chemistry 2008;283(42):28464-70.
2008: Ben de Kruijff; Vincent van Dam; Eefjan Breukink
Lipid II: a central component in bacterial cell wall synthesis and a target for antibiotics.
Prostaglandins, leukotrienes, and essential fatty acids 2008;79(3-5):117-21.
2008: Naomi E Kramer; Hester E Hasper; Patrick T C van den Bogaard; Siegfried Morath; Ben de Kruijff; Thomas Hartung; Eddy J. Smid; Eefjan Breukink; Jan Kok; Oscar P Kuipers
Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis.
Microbiology (Reading, England) 2008;154(Pt 6):1755-62.
2008: Leif Smith; Hester Hasper; Eefjan Breukink; Jan Novak; Jirí Cerkasov; J D Hillman; Shawanda Wilson-Stanford; Ravi S Orugunty
Elucidation of the antimicrobial mechanism of mutacin 1140.
Biochemistry 2008;47(10):3308-14.
2008: Yvonne M te Welscher; Hendrik H ten Napel; Miriam Masià Balagué; Cleiton Martins Souza; Howard Riezman; Ben de Kruijff; Eefjan Breukink
Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane.
The Journal of biological chemistry 2008;283(10):6393-401.
2008: Adeline Derouaux; Benoît Wolf; Claudine Fraipont; Eefjan Breukink; Martine Nguyen-Distèche; Mohammed Terrak
The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN.
Journal of bacteriology 2008;190(5):1831-4.
2008: Judicaël Parisot; Sarah Carey; Eefjan Breukink; Weng C Chan; Arjan Narbad; Boyan B Bonev
Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic.
Antimicrobial agents and chemotherapy 2008;52(2):612-8.
2007: Patrick Müller; Carolin Ewers; Ute Bertsche; Maria Anstett; Tanja Kallis; Eefjan Breukink; Claudine Fraipont; Mohammed Terrak; Martine Nguyen-Distèche; Waldemar Vollmer
The essential cell division protein FtsN interacts with the murein (peptidoglycan) synthase PBP1B in Escherichia coli.
The Journal of biological chemistry 2007;282(50):36394-402.
2007: Christopher J Arnusch; Hilbert M Branderhorst; Ben de Kruijff; Rob M J Liskamp; Eefjan Breukink; Roland J Pieters
Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides.
Biochemistry 2007;46(46):13437-42.
2007: Nathaniel Martin; Eefjan Breukink
Expanding role of lipid II as a target for lantibiotics.
Future microbiology 2007;2(5):513-25.
2007: Nourdin Ghalit; John F Reichwein; Hans W Hilbers; Eefjan Breukink; Dirk T S Rijkers; Rob M J Liskamp
Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics.
Chembiochem : a European journal of chemical biology 2007;8(13):1540-54.
2007: Vincent van Dam; Robert Sijbrandi; Matthijs Kol; Ewa Swiezewska; Ben de Kruijff; Eefjan Breukink
Transmembrane transport of peptidoglycan precursors across model and bacterial membranes.
Molecular microbiology 2007;64(4):1105-14.
2007: Mizuho Hasegawa; Akiko Kawasaki; Kangkang Yang; Yukari Fujimoto; Junya Masumoto; Eefjan Breukink; Gabriel Nuñez; Koichi Fukase; Naohiro Inohara
A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses.
The Journal of biological chemistry 2007;282(16):11757-64.
2006: Hester Emilie Hasper; Naomi E Kramer; James L Smith; Jeffrey D Hillman; Cherian Zachariah; Oscar P Kuipers; Ben de Kruijff; Eefjan Breukink
An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II.
Science (New York, N.Y.) 2006;313(5793):1636-7.
2006: Petra Born; Eefjan Breukink; Waldemar Vollmer
In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli.
The Journal of biological chemistry 2006;281(37):26985-93.
2006: Eefjan Breukink
A lesson in efficient killing from two-component lantibiotics.
Molecular microbiology 2006;61(2):271-3.
2006: Dragomir N Ganchev; Hester Emilie Hasper; Eefjan Breukink; Ben de Kruijff
Size and orientation of the lipid II headgroup as revealed by AFM imaging.
Biochemistry 2006;45(19):6195-202.
2006: Eefjan Breukink; Ben de Kruijff
Lipid II as a target for antibiotics.
Nature reviews. Drug discovery 2006;5(4):321-32.
2005: Ute Bertsche; Eefjan Breukink; Thomas Kast; Waldemar Vollmer
In vitro murein peptidoglycan synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli.
The Journal of biological chemistry 2005;280(45):38096-101.
2004: Boyan B Bonev; Eefjan Breukink; Ewa Swiezewska; Ben de Kruijff; Anthony Watts
Targeting extracellular pyrophosphates underpins the high selectivity of nisin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(15):1862-9.
2004: Naomi E Kramer; Eddy J. Smid; Jan Kok; Ben de Kruijff; Oscar P Kuipers; Eefjan Breukink
Resistance of Gram-positive bacteria to nisin is not determined by lipid II levels.
FEMS microbiology letters 2004;239(1):157-61.
2004: Shang-Te Danny Hsu; Eefjan Breukink; Eugene Tischenko; Mandy A G Lutters; Ben de Kruijff; Robert Kaptein; Alexandre Bonvin; Nico A J van Nuland
The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics.
Nature structural & molecular biology 2004;11(10):963-7.
2004: Hester Emilie Hasper; Ben de Kruijff; Eefjan Breukink
Assembly and stability of nisin-lipid II pores.
Biochemistry 2004;43(36):11567-75.
2003: Anne J Kleinnijenhuis; Marc C Duursma; Eefjan Breukink; Ron M A Heeren; albert heck
Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation.
Analytical chemistry 2003;75(13):3219-25.
2003: Els van den Brink-van der Laan; Jan-Willem P Boots; Robin E J Spelbrink; Gerda M Kool; Eefjan Breukink; J Antoinette Killian; Ben de Kruijff
Membrane interaction of the glycosyltransferase MurG: a special role for cardiolipin.
Journal of bacteriology 2003;185(13):3773-9.
2003: Eefjan Breukink; Hester E van Heusden; Pauline J Vollmerhaus; Ewa Swiezewska; Livia Brunner; Suzanne Walker; albert heck; Ben de Kruijff
Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes.
The Journal of biological chemistry 2003;278(22):19898-903.
2003: Shang-Te Danny Hsu; Eefjan Breukink; Gabriele Bierbaum; Hans-Georg Sahl; Ben de Kruijff; Robert Kaptein; Nico A J van Nuland; Alexandre Bonvin
NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity.
The Journal of biological chemistry 2003;278(15):13110-7.
2003: Pauline J Vollmerhaus; Eefjan Breukink; albert heck
Getting closer to the real bacterial cell wall target: biomolecular interactions of water-soluble lipid II with glycopeptide antibiotics.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(7):1556-65.
2002: Hester Emilie van Heusden; Ben de Kruijff; Eefjan Breukink
Lipid II induces a transmembrane orientation of the pore-forming peptide lantibiotic nisin.
Biochemistry 2002;41(40):12171-8.
2002: Shang-Te Danny Hsu; Eefjan Breukink; Ben de Kruijff; Robert Kaptein; Alexandre Bonvin; Nico A J van Nuland
Mapping the targeted membrane pore formation mechanism by solution NMR: the nisin Z and lipid II interaction in SDS micelles.
Biochemistry 2002;41(24):7670-6.
2002: Ellen J M van Kan; Rudy A Demel; Eefjan Breukink; Arie van der Bent; Ben de Kruijff
Clavanin permeabilizes target membranes via two distinctly different pH-dependent mechanisms.
Biochemistry 2002;41(24):7529-39.
2001: Imke Wiedemann; Eefjan Breukink; C van Kraaij; Oscar P Kuipers; Gabriele Bierbaum; Ben de Kruijff; Hans-Georg Sahl
Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity.
The Journal of biological chemistry 2001;276(3):1772-9.
2001: albert heck; P J Bonnici; Eefjan Breukink; D Morris; M Wills
Modification and inhibition of vancomycin group antibiotics by formaldehyde and acetaldehyde.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(4):910-6.
2000: Eefjan Breukink; P Ganz; Ben de Kruijff; J Seelig
Binding of Nisin Z to bilayer vesicles as determined with isothermal titration calorimetry.
Biochemistry 2000;39(33):10247-54.
2000: C van Kraaij; Eefjan Breukink; HS Rollema; R S Bongers; H A Kosters; Ben de Kruijff; Oscar P Kuipers
Engineering a disulfide bond and free thiols in the lantibiotic nisin Z.
European journal of biochemistry / FEBS 2000;267(3):901-9.
1999: Eefjan Breukink; Imke Wiedemann; C van Kraaij; Oscar P Kuipers; Hans-Georg Sahl; Ben de Kruijff
Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic.
Science (New York, N.Y.) 1999;286(5448):2361-4.
1999: Eefjan Breukink; Ben de Kruijff
The lantibiotic nisin, a special case or not?
Biochimica et biophysica acta 1999;1462(1-2):223-34.
1998: C van Kraaij; Eefjan Breukink; M A Noordermeer; Rudy A Demel; Roland Siezen; Oscar P Kuipers; Ben de Kruijff
Pore formation by nisin involves translocation of its C-terminal part across the membrane.
Biochemistry 1998;37(46):16033-40.
1998: Eefjan Breukink; C van Kraaij; Annemieke van Dalen; Rudy A Demel; Roland Siezen; Ben de Kruijff; Oscar P Kuipers
The orientation of nisin in membranes.
Biochemistry 1998;37(22):8153-62.
1997: C van Kraaij; Eefjan Breukink; HS Rollema; Roland Siezen; Rudy A Demel; Ben de Kruijff; Oscar P Kuipers
Influence of charge differences in the C-terminal part of nisin on antimicrobial activity and signaling capacity.
European journal of biochemistry / FEBS 1997;247(1):114-20.
1997: Eefjan Breukink; C van Kraaij; Rudy A Demel; Roland Siezen; Oscar P Kuipers; Ben de Kruijff
The C-terminal region of nisin is responsible for the initial interaction of nisin with the target membrane.
Biochemistry 1997;36(23):6968-76.
1996: A L Van Raalte; Rudy A Demel; G Verberkmoes; Eefjan Breukink; R C Keller; Ben de Kruijff
Influence of the signal sequence and chaperone SecB on the interaction between precursor protein prePhoE and phospholipids.
European journal of biochemistry / FEBS 1996;235(1-2):207-14.
1995: Eefjan Breukink; N Nouwen; A van Raalte; S Mizushima; Jan Tommassen; Ben de Kruijff
The C terminus of SecA is involved in both lipid binding and SecB binding.
The Journal of biological chemistry 1995;270(14):7902-7.
1994: R Kusters; Eefjan Breukink; A Gallusser; A Kuhn; Ben de Kruijff
A dual role for phosphatidylglycerol in protein translocation across the Escherichia coli inner membrane.
The Journal of biological chemistry 1994;269(2):1560-3.
1993: Eefjan Breukink; R C Keller; Ben de Kruijff
Nucleotide and negatively charged lipid-dependent vesicle aggregation caused by SecA. Evidence that SecA contains two lipid-binding sites.
FEBS letters 1993;331(1-2):19-24.
1993: JP van der Wolk; M Klose; Eefjan Breukink; R A Demel; Ben de Kruijff; Roland Freudl; Arnold J M Driessen
Characterization of a Bacillus subtilis SecA mutant protein deficient in translocation ATPase and release from the membrane.
Molecular microbiology 1993;8(1):31-42.
1992: Eefjan Breukink; R Kusters; Ben de Kruijff
In-vitro studies on the folding characteristics of the Escherichia coli precursor protein prePhoE. Evidence that SecB prevents the precursor from aggregating by forming a functional complex.
European journal of biochemistry / FEBS 1992;208(2):419-25.
1992: Eefjan Breukink; Rudy A Demel; G de Korte-Kool; Ben de Kruijff
SecA insertion into phospholipids is stimulated by negatively charged lipids and inhibited by ATP: a monolayer study.
Biochemistry 1992;31(4):1119-24.
1989: R Kusters; T de Vrije; Eefjan Breukink; Ben de Kruijff
SecB protein stabilizes a translocation-competent state of purified prePhoE protein.
The Journal of biological chemistry 1989;264(35):20827-30.