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Huaxi Xu

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Xin Wang; Chengbiao Wu; Bo Yang; Dongxian Zhang; Xiaofei Zhang; Yun-Wu Zhang; Yingjun Zhao; Ying Zhou; Hedieh Badie; Guojun Bu; Lei Cai; Yaomin Chen; Fred H Gage; Wanjin Hong; Peter F Johnson; Stuart A Lipton; Li Shen Loo; William C Mobley; Yangling Mu; Barbara Ranscht; Robert C Thompson; Huaxi Xu
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Jie Tian; Huaxi Xu; Jun Yan; Yue Zhang; Samuel Essien Baidoo; Hongye Guo; Liwei Lu; Jie Ma; Ke Ma; Shengjun Wang
β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells.
Chia-Chan Liu; Huaxi Xu; Takahisa Kanekiyo; Guojun Bu
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.

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All Publications

2013: Xin Wang; Chengbiao Wu; Bo Yang; Dongxian Zhang; Xiaofei Zhang; Yun-Wu Zhang; Yingjun Zhao; Ying Zhou; Hedieh Badie; Guojun Bu; Lei Cai; Yaomin Chen; Fred H Gage; Wanjin Hong; Peter F Johnson; Stuart A Lipton; Li Shen Loo; William C Mobley; Yangling Mu; Barbara Ranscht; Robert C Thompson; Huaxi Xu
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Nature medicine 2013;19(4):473-80.
2013: Jie Tian; Huaxi Xu; Jun Yan; Yue Zhang; Samuel Essien Baidoo; Hongye Guo; Liwei Lu; Jie Ma; Ke Ma; Shengjun Wang
β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells.
European journal of immunology 2013;43(5):1220-30.
2013: Chia-Chan Liu; Huaxi Xu; Takahisa Kanekiyo; Guojun Bu
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
Nature reviews. Neurology 2013;9(2):106-18.
2013: Isaac Dadzie; Bin Ni; Xiumei Sheng; Huaxi Xu; Shungao Xu; Haifang Zhang; Xiaolei Zhang; Xinxiang Huang
Identification and Characterization of a Cis-Encoded Antisense RNA Associated with the Replication Process of Salmonella enterica Serovar Typhi.
PloS one 2013;8(4):e61308.
2013: Dong Zheng; Fanzhi Kong; Tianqing Peng; Pei Shen; Xiaoju Shi; Zhaoliang Su; Qiang Sun; Jia Tong; Shengjun Wang; Huaxi Xu
Enhancing specific-antibody production to the ragB vaccine with GITRL that expand Tfh, IFN-γ(+) T cells and attenuates Porphyromonas gingivalis infection in mice.
PloS one 2013;8(4):e59604.
2013: Jian Ma; Yanpeng Wang; Meng Wei; Huaxi Xu; Dong Zheng; Tianqing Peng
Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways.
Cardiovascular research 2013;97(1):77-87.
2012: Jie Li; Mitsuru Shinohara; Huaxi Xu; Yunwu Zhang; Takahisa Kanekiyo; Mary Jo Ladu; Guojun Bu
Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.
The Journal of biological chemistry 2012;287(53):44593-601.
2012: Wei Song; Lai-Xi Wang; Huaxi Xu; Xifeng Yang; Igor C Almeida; Jieqing Chen; Elizabeth S Delyria; Wei Huang; Nuhad Ibrahim; Jun Soo Lee; Yunsen Li; Hongzhou Lu; Katja Michael; Elizabeth A Mittendorf; Jin Qu; Laszlo G Radvanyi; Silas P Rodrigues; Jeremy A Ross; Nathaniel S Schocker; Yinqiang Shi; Dapeng Zhou
MUC1 glycopeptide epitopes predicted by computational glycomics.
International journal of oncology 2012;41(6):1977-84.
2012: Xia Liu; Baoju Ji; Zhijun Jiao; Xin Lin; Yuxiang Tian; Shengjun Wang; Sheng Xia; Huaxi Xu; Sanrong Xu; Xun Xu; Qing Yin; Miaomiao Zhang; Qixiang Shao
PTD-hFOXP3 protein acts as an immune regulator to convert human CD4(+)CD25(-) T cells to regulatory T-like cells.
Journal of cellular biochemistry 2012;113(12):3797-809.
2012: Jia Tong; Shengjun Wang; Sheng Xia; Qingzhen Han; Xinxiang Huang; Qixiang Shao; Pei Shen; Zhaoliang Su; Dong Zheng; Huaxi Xu
Corynebacterium pyruviciproducens, as an immune modulator, can promote the activity of macrophages and up-regulate antibody response to particulate antigen.
Experimental biology and medicine (Maywood, N.J.) 2012;237(11):1322-30.
2012: Deyu Chen; Dongfang Dai; Qin Hu; Riyue Jiang; Chaoming Mao; Liang Shi; Shengjun Wang; Lichao Yu; Huaxi Xu
Chemokine/chemokine receptor interactions contribute to the accumulation of Th17 cells in patients with esophageal squamous cell carcinoma.
Human immunology 2012;73(11):1068-72.
2012: Z He; Z Jiao; Y Liu; Jie Ma; Q Shao; P Shen; S S Shotorbani; Z Su; J Tong; S Wang; T Wang; S Xia; J Gao; Huaxi Xu
HMGB1 promotes the differentiation of Th17 via up-regulating TLR2 and IL-23 of CD14+ monocytes from patients with rheumatoid arthritis.
Scandinavian journal of immunology 2012;76(5):483-90.
2012: Han Zhang; Xian Zhang; Yun-Wu Zhang; Fangfang Zhou; Guojun Bu; Quan Chen; Yaomin Chen; Ye-Guang Chen; Jing-Dong J Han; Xiumei Huang; Francesca-Fang Liao; Eliezer Masliah; John C Reed; Weiwei Wang; Bo Xian; Huaxi Xu
Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(44):15565-76.
2012: Yanfang Liu; Siamak Sandoghchian; Zhaoliang Su; Caixia Sun; Shengjun Wang; Jingping Yin; Hongyan Yuan; Haitao Zhu; Zhijun Jiao; Huaxi Xu
IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKCβ/Erk1/2/NF-κB-dependent signaling pathway.
International immunology 2012;24(10):605-12.
2012: Yaomin Chen; Todd E Golde; Xiumei Huang; Eliezer Masliah; Edward Rockenstein; Guojun Bu; Yun-Wu Zhang; Huaxi Xu
Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(33):11390-5.
2012: Young-Don Kwak; Jing Jing Li; Yaomin Chen; Qiyue Deng; Shiyong Diao; Eliezer Masliah; Jung-Joon Sung; Bin Wang; Ruishan Wang; Huaxi Xu; Raymond Xu; Francesca-Fang Liao
Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(32):10971-81.
2012: Chaoming Mao; Xiao Mou; Wei Qin; Danxia Bao; Deyu Chen; Wei Wu; Huaxi Xu; Guoyue Yuan; Shengjun Wang
A monoclonal antibody against human UL16-binding protein 3.
Hybridoma (2005) 2012;31(3):203-8.
2012: Jianguo Chen; Jianzhong Geng; Haibing Liu; Yingzhao Liu; Siamak Sandoghchian; Yan Shi; Zhaoliang Su; Jia Tong; Shengjun Wang; Dong Zheng; Huaxi Xu
Increased frequency of Th17 cells in the peripheral blood of children infected with enterovirus 71.
Journal of medical virology 2012;84(5):763-7.
2012: Xiumei Huang; Qilin Ma; Han Zhang; Yun-Wu Zhang; Yaomin Chen; Huaxi Xu
Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway.
Neurobiology of aging 2012;33(5):1007.e9-17.
2012: Wenhong Wang; Huaxi Xu; Mingquan Guo; Zhijun Jiao; Shihe Shao; Shengjun Wang
The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis.
Rheumatology international 2012;32(4):887-93.
2012: Shengjun Wang; Huaxi Xu; Min Yang; Samuel Essien Baidoo; Jianguo Chen; Zichun Hua; Zhijun Jiao; King-Hung Ko; Jie Ma; Chaoming Mao; Ye Shi; Jie Tian; Liwei Lu
Glucocorticoid-induced tumor necrosis factor receptor family-related protein exacerbates collagen-induced arthritis by enhancing the expansion of Th17 cells.
The American journal of pathology 2012;180(3):1059-67.
2012: Chenlu Zhu; Huaxi Xu; Jianguo Chen; Yingzhao Liu; Liwei Lu; Jie Ma; Xinyi Tang; Jie Tian; Jia Tong; Shengjun Wang
Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease.
The Journal of clinical endocrinology and metabolism 2012;97(3):943-50.
2012: Haifang Zhang; Hong Du; Xiaolan Ji; Linxiang Mao; Bin Ni; Xiumei Sheng; Huaxi Xu; Shungao Xu; Xinxiang Huang
OmpR may regulate the putative YehU/YehT two-component system in Salmonella enterica serovar Typhi under hypotonic growth condition.
Current microbiology 2012;64(3):283-9.
2012: Caixia Sun; Yanfang Liu; Zhaoliang Su; Jingping Yin; Hongyan Yuan; Chenglin Zhou; Huaxi Xu
Complex class 1 integron containing bla ( CTX-M-1 ) genes isolated from Escherichia coli: a potentially novel resistant gene-capturing tool kit.
Current microbiology 2012;64(3):265-70.
2012: Han Qingzhen; Shao Qixiang; Xia Sheng; Wang Shengjun; Baidoo Samuel Essien; S M Finegold; Tong Jia; Shen Pei; Liu Yanfang; Zhao Yang; Su Zhaoliang; Huaxi Xu
Corynebacterium pyruviciproducens promotes the production of ovalbumin specific antibody via stimulating dendritic cell differentiation and up-regulating Th2 biased immune response.
Vaccine 2012;30(6):1115-23.
2012: Yu Gong; Yong Gu; Chuanming Hao; Shanyan Lin; Huaxi Xu; Zhongye Xu; Fen Zhang; Feng Ding
Comparison of prognostic value of two kinds of severity scoring systems for hospital mortality prediction of elderly patients with acute kidney injury.
Aging clinical and experimental research 2012;24(1):74-8.
2012: Yan Xu; Yun Zhang; Dong Zheng; Jianguo Chen; Xiaoli Dai; Jingjing Gao; Yazhen Li; Yingzhao Liu; Zhaoliang Su; Jia Tong; Shengjun Wang; Chaoyang Wu; Huaxi Xu
Downregulation of Hlx closely related to the decreased expressions of T-bet and Runx3 in patients with gastric cancer may be associated with a pathological event leading to the imbalance of Th1/Th2.
Clinical & developmental immunology 2012;2012():949821.
2012: Haifang Zhang; Xin Zhao; Isaac Dadzie; Hong Du; Bin Ni; Qiang Wang; Huaxi Xu; Xinxiang Huang
Fis is essential for the stability of linear plasmid pBSSB1 and affects the motility of Salmonella enterica serovar Typhi.
PloS one 2012;7(7):e37462.
2012: Jie Ma; Chaoming Mao; Jie Tian; Jia Tong; Samuel Essien Baidoo; Jianguo Chen; Zhijun Jiao; Liwei Lu; Bin Ma; Wei Wu; Huaxi Xu; Min Yang; Chenlu Zhu; Shengjun Wang
Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis.
Clinical & developmental immunology 2012;2012():827480.
2012: Siamak Sandoghchian Shotorbani; Zhaoliang Su; Qiang Sun; Shengjun Wang; Yan Xu; Yuan Xue; Heng Yang; Yun Zhang; Dong Zheng; Zhiqiang He; Liwei Lu; Qixiang Shao; Huaxi Xu
Over-expression of Hlx homeobox gene in DC2.4 dendritic cell enhances its maturation and antigen presentation.
Cellular immunology 2012;275(1-2):61-8.
2012: Yan Shi; Zhaoliang Su; Jia Tong; Shengjun Wang; Jianguo Chen; Xinxiang Huang; Zhijun Jiao; Yingzhao Liu; Yanfang Liu; Liwei Lu; Siamak Sandoghchian Shotorbani; Yan Xu; Dong Zheng; Huaxi Xu
Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis.
Clinical & developmental immunology 2012;2012():295081.
2011: Zhaoliang Su; Caixia Sun; Shengjun Wang; Zhijun Jiao; Yanfang Liu; Tianqing Peng; Siamak Sandoghchian; Yu Zhang; Dong Zheng; Chenglin Zhou; Haitao Zhu; Huaxi Xu
HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion.
European journal of immunology 2011;41(12):3586-95.
2011: Guorui Yao; Jie Zhou; Yinong Zong; Shenyan Gu; Irimpan I Mathews; Huaxi Xu; Rongsheng Jin
Crystal structure of the glutamate receptor GluA1 N-terminal domain.
The Biochemical journal 2011;438(2):255-63.
2011: Min Wang; Zhe Luo; Hong Du; Shungao Xu; Bin Ni; Haifang Zhang; Xiumei Sheng; Huaxi Xu; Xinxiang Huang
Molecular characterization of a functional type VI secretion system in Salmonella enterica serovar Typhi.
Current microbiology 2011;63(1):22-31.
2011: Jia Tong; Chengxu Liu; Paula Summanen; Huaxi Xu; Sydney M Finegold
Application of quantitative real-time PCR for rapid identification of Bacteroides fragilis group and related organisms in human wound samples.
Anaerobe 2011;17(2):64-8.
2011: Jie Ma; Shengjun Wang; Bin Ma; Chaoming Mao; Jia Tong; Min Yang; Chaoyang Wu; Zhijun Jiao; Liwei Lu; Huaxi Xu
Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma.
Cancer letters 2011;301(2):142-50.
2011: Xiaochun Sun; Hua Cai; Hui Qian; Wei Zhu; Yongmin Yan; Huaxi Xu; Wenrong Xu
Mesenchymal stem cells isolated from human uterine cervix cancer tissues.
Cell biology international 2011;35(2):119-23.
2011: Hong Du; Xiumei Sheng; Haifang Zhang; Xin Zou; Bin Ni; Shungao Xu; Xueming Zhu; Huaxi Xu; Xinxiang Huang
RpoE may promote flagellar gene expression in Salmonella enterica serovar typhi under hyperosmotic stress.
Current microbiology 2011;62(2):492-500.
2011: Fanzhi Kong; Yanfang Liu; Zhaoliang Su; Caixia Sun; Shengjun Wang; Jingping Yin; Hongyan Yuan; Dong Zheng; Chenglin Zhou; Jie Fang; Huaxi Xu
Role of positive selection in functional divergence of mammalian neuronal apoptosis inhibitor proteins during evolution.
Journal of biomedicine & biotechnology 2011;2011():809765.
2011: Jie Tian; Jia Tong; Shengjun Wang; Chaoyang Wu; Jun Yan; Jianguo Chen; Zhijun Jiao; Yingzhao Liu; Liwei Lu; Bin Ma; Jie Ma; Chaoming Mao; Qixiang Shao; Huaxi Xu
Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4+CD25+ regulatory T cells and enhances the effector T cell proliferation.
Cellular immunology 2011;270(2):183-7.
2011: Dapeng Zhou; Steven B Levery; Fong-Fu Hsu; Peng G Wang; Susann Teneberg; Igor Almeida; Yunsen Li; Huaxi Xu; Lai-Xi Wang; Chengfeng Xia; Nuhad K Ibrahim; Katja Michael
Immunologic mapping of glycomes: implications for cancer diagnosis and therapy.
Frontiers in bioscience (Scholar edition) 2011;3():1520-32.
2011: Young-Don Kwak; Ruishan Wang; Jing Jing Li; Yun-Wu Zhang; Huaxi Xu; Francesca-Fang Liao
Differential regulation of BACE1 expression by oxidative and nitrosative signals.
Molecular neurodegeneration 2011;6():17.
2011: Yun-Wu Zhang; Robert Thompson; Han Zhang; Huaxi Xu
APP processing in Alzheimer's disease.
Molecular brain 2011;4():3.
2011: Jianguo Chen; Zhaoliang Su; Yingzhao Liu; Siamak Sandoghchian; Dong Zheng; Shengjun Wang; Huaxi Xu
Herbaspirillum species: a potential pathogenic bacteria isolated from acute lymphoblastic leukemia patient.
Current microbiology 2011;62(1):331-3.
2010: Ling-Xiang Mao; Bing Wu; Wu-Xin Bao; Fang-An Han; Lan Xu; Qin-Juan Ge; Jing Yang; Zhao-Hu Yuan; Chun-Hua Miao; Xin-Xiang Huang; Chiyu Zhang; Huaxi Xu
Epidemiology of hand, foot, and mouth disease and genotype characterization of Enterovirus 71 in Jiangsu, China.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2010;49(2):100-4.
2010: Xiumei Huang; Yaomin Chen; Wu-Bo Li; Stanley N Cohen; Francesca-Fang Liao; Limin Li; Huaxi Xu; Yun-Wu Zhang
The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation.
Human molecular genetics 2010;19(19):3835-43.
2010: Y Shi; H Wang; Z Su; J Chen; Y Xue; S Wang; Y Xue; Z He; H Yang; C Zhou; F Kong; Y Liu; P Yang; L Lu; Q Shao; X Huang; Huaxi Xu
Differentiation imbalance of Th1/Th17 in peripheral blood mononuclear cells might contribute to pathogenesis of Hashimoto's thyroiditis.
Scandinavian journal of immunology 2010;72(3):250-5.
2010: Dawei Cui; Shengjun Wang; Yu Chen; Jia Tong; Jie Ma; Li Tang; Xianzhi Yang; Ye Shi; Jie Tian; Liwei Lu; Huaxi Xu
An isoleucine-zipper motif enhances costimulation of human soluble trimeric GITR ligand.
Cellular & molecular immunology 2010;7(4):316-22.
2010: Jia Tong; Chengxu Liu; Paula H Summanen; Huaxi Xu; Sydney M Finegold
Corynebacterium pyruviciproducens sp. nov., a pyruvic acid producer.
International journal of systematic and evolutionary microbiology 2010;60(Pt 5):1135-40.
2010: Min Yang; Lingyun Sun; Shengjun Wang; King-Hung Ko; Huaxi Xu; Bo-Jian Zheng; Xuetao Cao; Liwei Lu
Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3321-5.
2010: Jiabo Hu; fan hong; Dongsheng Liu; Shuhong Zhang; Feng Zhang; Huaxi Xu
DNMT3B promoter polymorphism and risk of gastric cancer.
Digestive diseases and sciences 2010;55(4):1011-6.
2010: Young-Don Kwak; Bin Wang; Wei Pan; Huaxi Xu; Xuejun Jiang; Francesca-Fang Liao
Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.
The Journal of biological chemistry 2010;285(13):9847-57.
2010: Yun-Wu Zhang; Huaxi Xu
Substrate check of gamma-secretase.
Nature structural & molecular biology 2010;17(2):140-1.
2010: Young-Don Kwak; Tao Ma; Shiyong Diao; Xue Zhang; Yaomin Chen; Janet Hsu; Stuart A Lipton; Eliezer Masliah; Huaxi Xu; Francesca-Fang Liao
NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration.
Molecular neurodegeneration 2010;5():49.
2010: Ayelén Bulloj; María C Leal; Huaxi Xu; Eduardo M Castaño; Laura Morelli
Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease.
Journal of Alzheimer's disease : JAD 2010;19(1):79-95.
2009: Yun-Wu Zhang; Shijie Liu; Xue Zhang; Wu-Bo Li; Yaomin Chen; Xiumei Huang; Liangwu Sun; Wenjie Luo; William J Netzer; Richard Threadgill; Gordon Wiegand; Ruishan Wang; Stanley N Cohen; Paul Greengard; Francesca-Fang Liao; Limin Li; Huaxi Xu
A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation.
Neuron 2009;64(3):328-40.
2009: Julie Dunys; Jean Sevalle; Emilie Giaime; Raphaëlle Pardossi-Piquard; Michael P Vitek; Paul Renbaum; Ephrat Levy-Lahad; Yun-Wu Zhang; Huaxi Xu; Frédéric Checler; Cristine Alves da Costa
p53-dependent control of transactivation of the Pen2 promoter by presenilins.
Journal of cell science 2009;122(Pt 21):4003-8.
2009: Jianguo Chen; Zhaoliang Su; Yingzhao Liu; Shengjun Wang; Xiaoli Dai; Yazhen Li; Sufang Peng; Qixiang Shao; Haifang Zhang; Ping Wen; Jianren Yu; Xinxiang Huang; Huaxi Xu
Identification and characterization of class 1 integrons among Pseudomonas aeruginosa isolates from patients in Zhenjiang, China.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2009;13(6):717-21.
2009: Cherry Kam Chun Lo; Queenie Lai Kwan Lam; Min Yang; King-Hung Ko; Lingyun Sun; Rui Ma; Shengjun Wang; Huaxi Xu; Sidney Tam; Chang-You Wu; Bo-Jian Zheng; Liwei Lu
Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow.
Cellular & molecular immunology 2009;6(5):353-60.
2009: Xiaoqing You; Yun-Wu Zhang; Yaomin Chen; Xiumei Huang; Raymond Xu; Xihua Cao; Jiebo Chen; Yun Liu; Xiaokun Zhang; Huaxi Xu
Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid.
Journal of neurochemistry 2009;111(1):142-9.
2009: Tao Ma; YongBo Zhao; Young-Don Kwak; Zhangmin Yang; Robert Thompson; Zhijun Luo; Huaxi Xu; Francesca-Fang Liao
Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(36):11226-36.
2009: Haifang Zhang; Xiumei Sheng; Shungao Xu; Yulin Gao; Hong Du; Junrong Li; Huaxi Xu; Xinxiang Huang
Global transcriptional response of Salmonella enterica serovar Typhi to anti-z66 antiserum.
FEMS microbiology letters 2009;298(1):51-5.
2009: Huaxi Xu; Zhaoliang Su; Shengjun Wang; Xiaoli Dai; Jianguo Chen; Fanzhi Kong; Yazhen Li; Sufang Peng; Qixiang Shao; Liwei Lu; T Ezaki
Four novel resistance integron gene-cassette occurrences in bacterial isolates from zhenjiang, china.
Current microbiology 2009;59(2):113-7.
2009: Gufeng Qiu; Suoying Wang; Shengjun Wang; Qixiang Shao; Jie Ma; Ming Yang; Xiaopeng Xu; Chaoming Mao; Zhaoliang Su; Xinxiang Huang; Huaxi Xu
[Adeno-associated virus mediated T-bet gene transfer into SGC-7901 cell to regulate IFN-gamma production].
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 2009;26(3):606-9, 619.
2009: Yun Liu; Yun-Wu Zhang; Xin Wang; Han Zhang; Xiaoqing You; Francesca-Fang Liao; Huaxi Xu
Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1.
The Journal of biological chemistry 2009;284(18):12145-52.
2009: Xin Zou; Xinxiang Huang; Shungao Xu; Liping Zhou; Xiumei Sheng; Haifang Zhang; Huaxi Xu; Takayuki Ezaki
Identification of a fljA gene on a linear plasmid as the repressor gene of fliC in Salmonella enterica serovar Typhi.
Microbiology and immunology 2009;53(4):191-7.
2009: Yaomin Chen; Kun Zhou; Ruishan Wang; Yun Liu; Young-Don Kwak; Tao Ma; Robert C Thompson; Yongbo Zhao; Layton Smith; Laura Gasparini; Zhijun Luo; Huaxi Xu; Francesca-Fang Liao
Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3907-12.
2009: Francesca-Fang Liao; Huaxi Xu
Insulin signaling in sporadic Alzheimer's disease.
Science signaling 2009;2(74):pe36.
2008: Zhaoliang Su; Xiaoli Dai; Jianguo Chen; Fanzhi Kong; Huifang Wang; Yazhen Li; Sufang Peng; Shengjun Wang; Qixiang Shao; Liwe Lv; Huaxi Xu
The bla(CTX-M-1) gene located in a novel complex class I integron bearing an ISCR1 element in Escherichia coli isolates from Zhenjiang, China.
The Journal of antimicrobial chemotherapy 2008;62(5):1150-1.
2008: Cherry Kam Chun Lo; Queenie Lai Kwan Lam; Lingyun Sun; Shengjun Wang; King-Hung Ko; Huaxi Xu; Chang-You Wu; Bo-Jian Zheng; Liwei Lu
Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production.
Arthritis and rheumatism 2008;58(9):2700-11.
2008: Chaoming Mao; Shengjun Wang; Qian Jiang; Jia Tong; Jie Ma; Min Yang; Xiaopeng Xu; Gufeng Qiu; Qixiang Shao; Long Li; Huaxi Xu
Increased CD4CD25+FOXP3+ regulatory T Cells in cancer patients from conversion of CD4+CD25- T cells through tumor-derived factors.
Onkologie 2008;31(5):243-8.
2008: Han Zhang; Runzhong Liu; Ruishan Wang; Shuigen Hong; Huaxi Xu; Yun-Wu Zhang
Presenilins regulate the cellular level of the tumor suppressor PTEN.
Neurobiology of aging 2008;29(5):653-60.
2008: Shungao Xu; Haifan Zhang; Xiumei Sheng; Huaxi Xu; Xinxiang Huang
Transcriptional expression of fljB:z66, a flagellin gene located on a novel linear plasmid of Salmonella enterica serovar Typhi under environmental stresses.
The new microbiologica 2008;31(2):241-7.
2008: Huaqi Xiong; Debbie Callaghan; Aimee Jones; Douglas G. Walker; Lih-Fen Lue; Thomas Beach; Lucia I Sue; John Woulfe; Huaxi Xu; Danica Stanimirovic; Wandong Zhang
Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production.
Neurobiology of disease 2008;29(3):422-37.
2008: Ayelén Bulloj; María C Leal; Ezequiel I Surace; Xue Zhang; Huaxi Xu; Maria D Ledesma; Eduardo M Castaño; Laura Morelli
Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation.
Molecular neurodegeneration 2008;3():22.
2008: Min Yang; Shengjun Wang; Suoying Wang; Jie Ma; Xiaopeng Xu; Chaoming Mao; Bing Ma; Jia Tong; Gufeng Qiu; Qixiang Shao; Qing Ding; Huaxi Xu
Tat-mediated intracellular delivery of T-bet protein into THP-1 cells can induce Th1-type response.
Immunological investigations 2008;37(2):97-111.
2007: Yun-Wu Zhang; Huaxi Xu
Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism.
Current molecular medicine 2007;7(7):687-96.
2007: Shungao Xu; Xinxiang Huang; Huaxi Xu; Chiyu Zhang
Improved prediction of coreceptor usage and phenotype of HIV-1 based on combined features of V3 loop sequence using random forest.
Journal of microbiology (Seoul, Korea) 2007;45(5):441-6.
2007: Zhaoliang Su; Huaxi Xu; Jianguo Chen
Avian influenza: should China be alarmed?
Yonsei medical journal 2007;48(4):586-94.
2007: Sam Gandy; Yun-Wu Zhang; Annat Ikin; Stephen D Schmidt; Alexey Bogush; Efrat Levy; Roxanne Sheffield; Ralph A. Nixon; Francesca-Fang Liao; Paul Mathews; Huaxi Xu; Michelle E Ehrlich
Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.
Journal of neurochemistry 2007;102(3):619-26.
2007: Yun-Wu Zhang; Ruishan Wang; Qiang Liu; Han Zhang; Francesca-Fang Liao; Huaxi Xu
Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10613-8.
2007: Yun-Wu Zhang; Huaxi Xu
Alteration of beta-secretase traffic by the receptor tyrosine kinase signaling pathway - a new mechanism for regulating Alzheimer's beta-amyloid production.
Cell research 2007;17(5):385-6.
2007: Xian Zhang; Kun Zhou; Ruishan Wang; Jiankun Cui; Stuart A Lipton; Francesca-Fang Liao; Huaxi Xu; Yun-Wu Zhang
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
The Journal of biological chemistry 2007;282(15):10873-80.
2007: Ping Lin; Feng Li; Yun-Wu Zhang; Haining Huang; Gang Tong; Marilyn G Farquhar; Huaxi Xu
Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis.
Journal of neurochemistry 2007;100(6):1505-14.
2007: Hong-Lian Li; Hai-Hong Wang; Shi-Jie Liu; Yan-Qiu Deng; Yong-Jie Zhang; Qing Tian; Xiao-Chuan Wang; Xiao-Qian Chen; Ying Yang; Jia-Yu Zhang; Qun Wang; Huaxi Xu; Francesca-Fang Liao; Jian-Zhi Wang
Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3591-6.
2006: Shengjun Wang; Huaxi Xu; Yongzhong Wang; Jie Ma; Chaoming Mao; Qixiang Shao; Bin Ma; Wenrong Xu; Shengli Yang
Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice.
International journal of molecular medicine 2006;18(6):1193-9.
2006: Guiqiong He; Hong Qing; Fang Cai; Clement Kwok; Huaxi Xu; Gang G. Yu; alan bernstein; Weihong Song
Ubiquitin-proteasome pathway mediates degradation of APH-1.
Journal of neurochemistry 2006;99(5):1403-12.
2006: Huaxi Xu; Ruishan Wang; Yun-Wu Zhang; Xue Zhang
Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease.
Annals of the New York Academy of Sciences 2006;1089():324-42.
2006: Ze-Fen Wang; Hong-Lian Li; Xia-Chun Li; Qi Zhang; Qing Tian; Qun Wang; Huaxi Xu; Jian-Zhi Wang
Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture.
Journal of neurochemistry 2006;98(4):1167-75.
2006: Zhaoliang Su; Huaxi Xu; Chiyu Zhang; Shihe Shao; Liangju Li; Hua Wang; Huifang Wang; Gufeng Qiu
Mutations in Helicobacter pylori porD and oorD genes may contribute to furazolidone resistance.
Croatian medical journal 2006;47(3):410-5.
2006: Xue Zhang; Feng Li; Ayelen Bulloj; Yun-Wu Zhang; Gang Tong; Zhuohua Zhang; Francesca-Fang Liao; Huaxi Xu
Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1272-4.
2006: Ruishan Wang; Yun-Wu Zhang; Xian Zhang; Runzhong Liu; Xue Zhang; Shuigen Hong; Kun Xia; Jiahui Xia; Zhuohua Zhang; Huaxi Xu
Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1275-7.
2006: Dongming Cai; William Netzer; Minghao Zhong; Yixin Lin; Guangwei Du; Michael Frohman; David A Foster; Sangram S Sisodia; Huaxi Xu; Fred S Gorelick; Paul Greengard
Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1941-6.
2006: Dongming Cai; Minghao Zhong; Runsheng Wang; William Netzer; Dennis Shields; Hui Zheng; Sangram S Sisodia; David A Foster; Fred S Gorelick; Huaxi Xu; Paul Greengard
Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1936-40.
2006: Ruishan Wang; Yun-Wu Zhang; Ping Sun; Runzhong Liu; Xian Zhang; Xue Zhang; Kun Xia; Jiahui Xia; Huaxi Xu; Zhuohua Zhang
Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB.
Molecular and cellular biology 2006;26(4):1347-54.
2006: Xue Zhang; Yun-Wu Zhang; Shijie Liu; Ayelen Bulloj; Gang Tong; Zhuohua Zhang; Francesca-Fang Liao; Huaxi Xu
Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau.
Molecular neurodegeneration 2006;1():7.
2006: Kulandaivelu S Vetrivel; Yun-Wu Zhang; Huaxi Xu; Gopal Thinakaran
Pathological and physiological functions of presenilins.
Molecular neurodegeneration 2006;1():4.
2006: Xinxiang Huang; Huaxi Xu; Mohammad Monir Sha; Licheng Zhao; Kiyofumi Ohkusu; Yoshiaki Kawamura; Takayuki Ezaki
Virulence-defective strains of Salmonella enterica serovar Typhi as candidates for education at level 2 facilities.
Microbiology and immunology 2006;50(4):273-9.
2005: Ping Han; Fei Dou; Feng Li; Xue Zhang; Yun-Wu Zhang; Hui Zheng; Stuart A Lipton; Huaxi Xu; Francesca-Fang Liao
Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(50):11542-52.
2005: Yun-Wu Zhang; Wen-jie Luo; Hong Wang; Ping Lin; Kulandaivelu S Vetrivel; Fang Liao; Feng Li; Philip C Wong; Marilyn G Farquhar; Gopal Thinakaran; Huaxi Xu
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
The Journal of biological chemistry 2005;280(17):17020-6.
2004: Kulandaivelu S Vetrivel; Haipeng Cheng; William Lin; Takashi Sakurai; Tong Li; Nobuyuki Nukina; Philip C Wong; Huaxi Xu; Gopal Thinakaran
Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.
The Journal of biological chemistry 2004;279(43):44945-54.
2004: Hong Wang; Wen-jie Luo; Yun-Wu Zhang; Yueming Li; Gopal Thinakaran; Paul Greengard; Huaxi Xu
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components.
The Journal of biological chemistry 2004;279(39):40560-6.
2004: Laura Gasparini; Laura Rusconi; Huaxi Xu; Piero Del Soldato; Ennio Ongini
Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures.
Journal of neurochemistry 2004;88(2):337-48.
2003: Shi Jie Liu; Ai Hong Zhang; Hong Lian Li; Qun Wang; Heng Mei Deng; William Netzer; Huaxi Xu; Jian-Zhi Wang
Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.
Journal of neurochemistry 2003;87(6):1333-44.
2003: William Netzer; Fei Dou; Dongming Cai; Darren R Veach; Stephanie Jean; Yueming Li; William G Bornmann; Bayard Clarkson; Huaxi Xu; Paul Greengard
Gleevec inhibits beta-amyloid production but not Notch cleavage.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12444-9.
2003: Laura Gasparini; Huaxi Xu
Potential roles of insulin and IGF-1 in Alzheimer's disease.
Trends in neurosciences 2003;26(8):404-6.
2003: Wen-jie Luo; Hong Wang; Hongqiao Li; Benny S Kim; Sanjiv Shah; Hahn-Jun Lee; Gopal Thinakaran; TAE-WAN KIM; Gang G. Yu; Huaxi Xu
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
The Journal of biological chemistry 2003;278(10):7850-4.
2003: Dongming Cai; Jae Yoon Leem; Jeffrey P Greenfield; Pei Wang; Benny S Kim; Runsheng Wang; Kryslaine O Lopes; Seong-Hun Kim; Hui Zheng; Paul Greengard; Sangram S Sisodia; Gopal Thinakaran; Huaxi Xu
Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.
The Journal of biological chemistry 2003;278(5):3446-54.
2003: Fei Dou; William Netzer; Kentaro Tanemura; Feng Li; F Ulrich Hartl; Akihiko Takashima; Gunnar K Gouras; Paul Greengard; Huaxi Xu
Chaperones increase association of tau protein with microtubules.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):721-6.
2002: Reisuke H Takahashi; Teresa A Milner; Feng Li; Ellen E Nam; Mark A Edgar; Haruyasu Yamaguchi; M Flint Beal; Huaxi Xu; Paul Greengard; Gunnar K Gouras
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
The American journal of pathology 2002;161(5):1869-79.
2002: Jae Yoon Leem; Carlos A Saura; Claus U Pietrzik; John C Christianson; Christian P Wanamaker; LaShaunda T King; Margaret L Veselits; Taisuke Tomita; Laura Gasparini; Takeshi Iwatsubo; Huaxi Xu; William N Green; Edward H Koo; Gopal Thinakaran
A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.
Neurobiology of disease 2002;11(1):64-82.
2002: Yuan Luo; Julie V Smith; Vijaykumar Paramasivam; Adam Burdick; Kenneth J Curry; Justin P Buford; Ikhlas Khan; William Netzer; Huaxi Xu; Peter Butko
Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12197-202.
2002: Zhongxian Lu; James T Murray; Wenjie Luo; Hongling Li; Xiaoping Wu; Huaxi Xu; Jonathan M Backer; Ye-Guang Chen
Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis.
The Journal of biological chemistry 2002;277(33):29363-8.
2002: Laura Gasparini; William Netzer; Paul Greengard; Huaxi Xu
Does insulin dysfunction play a role in Alzheimer's disease?
Trends in pharmacological sciences 2002;23(6):288-93.
2002: Jae Yoon Leem; Shrijay Vijayan; Ping Han; Dongming Cai; Michael Machura; Kryslaine O Lopes; Margaret L Veselits; Huaxi Xu; Gopal Thinakaran
Presenilin 1 is required for maturation and cell surface accumulation of nicastrin.
The Journal of biological chemistry 2002;277(21):19236-40.
2002: Jeffrey P Greenfield; Lawrence Leung; Dongming Cai; Krista Kaasik; Rachel S Gross; Enrique Rodriguez-Boulan; Paul Greengard; Huaxi Xu
Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis.
The Journal of biological chemistry 2002;277(14):12128-36.
2001: Joanne Hama; Huaxi Xu; mitchell goldfarb; Daniel C Weinstein
SNT-1/FRS2alpha physically interacts with Laloo and mediates mesoderm induction by fibroblast growth factor.
Mechanisms of development 2001;109(2):195-204.
2001: Chunjiang Yu; Seong-Hun Kim; Takeshi Ikeuchi; Huaxi Xu; L Gasparini; Rong Wang; Sangram S Sisodia
Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.
The Journal of biological chemistry 2001;276(47):43756-60.
2001: Huaxi Xu; mitchell goldfarb
Multiple effector domains within SNT1 coordinate ERK activation and neuronal differentiation of PC12 cells.
The Journal of biological chemistry 2001;276(16):13049-56.
2001: L Gasparini; Gunnar K Gouras; Runsheng Wang; Rachel S Gross; M Flint Beal; Paul Greengard; Huaxi Xu
Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(8):2561-70.
2000: Gunnar K Gouras; Huaxi Xu; Rachel S Gross; Jeffrey P Greenfield; B Hai; Runsheng Wang; Paul Greengard
Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1202-5.
2000: Jeffrey P Greenfield; Rachel S Gross; Gunnar K Gouras; Huaxi Xu
Cellular and molecular basis of beta-amyloid precursor protein metabolism.
Frontiers in bioscience : a journal and virtual library 2000;5():D72-83.
2000: Gunnar K Gouras; J Tsai; J Naslund; B Vincent; Mark A Edgar; F Checler; Jeffrey P Greenfield; Vahram Haroutunian; Joseph Buxbaum; Huaxi Xu; Paul Greengard; Norman Richard Relkin
Intraneuronal Abeta42 accumulation in human brain.
The American journal of pathology 2000;156(1):15-20.
1999: Jeffrey P Greenfield; Huaxi Xu; Paul Greengard; Sam Gandy; M Seeger
Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-beta precursor protein.
The Journal of biological chemistry 1999;274(48):33843-6.
1999: P Zhang; J Y Mo; Aymee Perez; A Leon; Li Liu; Nayef Mazloum; Huaxi Xu; Marietta Y W T Lee
Direct interaction of proliferating cell nuclear antigen with the p125 catalytic subunit of mammalian DNA polymerase delta.
The Journal of biological chemistry 1999;274(38):26647-53.
1999: Jeffrey P Greenfield; J Tsai; Gunnar K Gouras; B Hai; Gopal Thinakaran; F Checler; Sangram S Sisodia; Paul Greengard; Huaxi Xu
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):742-7.
1998: Huaxi Xu; K W Lee; mitchell goldfarb
Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.
The Journal of biological chemistry 1998;273(29):17987-90.
1998: Huaxi Xu; Gunnar K Gouras; Jeffrey P Greenfield; B Vincent; J Naslund; L Mazzarelli; G Fried; J N Jovanovic; M Seeger; Norman Richard Relkin; F Liao; F Checler; Joseph Buxbaum; Brian T Chait; Gopal Thinakaran; Sangram S Sisodia; Runsheng Wang; Paul Greengard; Sam Gandy
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Nature medicine 1998;4(4):447-51.
1998: Jeffrey P Greenfield; Gunnar K Gouras; Huaxi Xu
Cellular and molecular basis of beta-amyloid precursor protein metabolism.
Frontiers in bioscience : a journal and virtual library 1998;3():d399-407.
1997: Huaxi Xu; D Sweeney; Rong Wang; Gopal Thinakaran; Amy Lo; Sangram S Sisodia; Paul Greengard; Sam Gandy
Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3748-52.
1996: Huaxi Xu; D Sweeney; Paul Greengard; Sam Gandy
Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4081-4.
1995: Huaxi Xu; Paul Greengard; Sam Gandy
Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.
The Journal of biological chemistry 1995;270(40):23243-5.