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Heng Xu

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Subramaniam Ananthan; Edward J Bilsky; Christina M Dersch; Denise Giuvelis; Nicholas McGlinchey; Surendra K Saini; Heng Xu; Richard B Rothman
14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects.
Elliott J Sally; Heng Xu; Christina M Dersch; Ling-Wei Hsin; Li-Te Chang; Thomas E Prisinzano; Denise S Simpson; Denise Giuvelis; Kenner C Rice; Arthur E Jacobson; Kejun Cheng; Edward J Bilsky; Richard B Rothman
Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor.
Heng Xu; Xiaoying Wang; John S Partilla; Kristen Bishop-Mathis; tova benaderet; Christina M Dersch; Denise S Simpson; Thomas E Prisinzano; Richard B Rothman
Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors.

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2012: Subramaniam Ananthan; Edward J Bilsky; Christina M Dersch; Denise Giuvelis; Nicholas McGlinchey; Surendra K Saini; Heng Xu; Richard B Rothman
14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects.
Journal of medicinal chemistry 2012;55(19):8350-63.
2010: Elliott J Sally; Heng Xu; Christina M Dersch; Ling-Wei Hsin; Li-Te Chang; Thomas E Prisinzano; Denise S Simpson; Denise Giuvelis; Kenner C Rice; Arthur E Jacobson; Kejun Cheng; Edward J Bilsky; Richard B Rothman
Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor.
Synapse (New York, N.Y.) 2010;64(4):280-8.
2008: Heng Xu; Xiaoying Wang; John S Partilla; Kristen Bishop-Mathis; tova benaderet; Christina M Dersch; Denise S Simpson; Thomas E Prisinzano; Richard B Rothman
Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors.
Brain research bulletin 2008;77(1):49-54.
2008: John M Rutherford; Jia Bei Wang; Heng Xu; Christina M Dersch; John S Partilla; Kenner C Rice; Richard B Rothman
Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors.
Peptides 2008;29(8):1424-31.
2007: Heng Xu; John S Partilla; Xiaoying Wang; John M Rutherford; Kevin Tidgewell; Thomas E Prisinzano; Laura M Bohn; Richard B Rothman
A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence.
Synapse (New York, N.Y.) 2007;61(3):166-75.
2007: Richard B Rothman; Daniel L Murphy; Heng Xu; Jonathan A Godin; Christina M Dersch; John S Partilla; Kevin Tidgewell; Matthew Schmidt; Thomas E Prisinzano
Salvinorin A: allosteric interactions at the mu-opioid receptor.
The Journal of pharmacology and experimental therapeutics 2007;320(2):801-10.
2006: Xiaoying Wang; Heng Xu; Richard B Rothman
Regulation of the rat brain endothelin system by endogenous beta-endorphin.
Peptides 2006;27(4):769-74.
2005: Heng Xu; Xiaoying Wang; Darin Zimmerman; Emily Boja; Jia Bei Wang; Edward J Bilsky; Richard B Rothman
Chronic morphine up-regulates G alpha12 and cytoskeletal proteins in Chinese hamster ovary cells expressing the cloned mu opioid receptor.
The Journal of pharmacology and experimental therapeutics 2005;315(1):248-55.
2005: Xiaoying Wang; Michael H Baumann; Heng Xu; Marisela Morales; Richard B Rothman
(+/-)-3,4-Methylenedioxymethamphetamine administration to rats does not decrease levels of the serotonin transporter protein or alter its distribution between endosomes and the plasma membrane.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1002-12.
2004: Xiaoying Wang; Michael H Baumann; Heng Xu; Richard B Rothman
3,4-methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic protein.
Synapse (New York, N.Y.) 2004;53(4):240-8.
2004: Heng Xu; Xiaoying Wang; Jun Wang; Richard B Rothman
Opioid peptide receptor studies. 17. Attenuation of chronic morphine effects after antisense oligodeoxynucleotide knock-down of RGS9 protein in cells expressing the cloned Mu opioid receptor.
Synapse (New York, N.Y.) 2004;52(3):209-17.
2004: Xiaoying Wang; Heng Xu; Richard B Rothman
Intracerebroventricular administration of anti-endothelin-1 IgG selectively upregulates endothelin-A and kappa opioid receptors.
Neuroscience 2004;129(3):751-6.
2003: Richard B Rothman; Nga Vu; Xiaoying Wang; Heng Xu
Endogenous CART peptide regulates mu opioid and serotonin 5-HT(2A) receptors.
Peptides 2003;24(3):413-7.
2003: Heng Xu; Yi-Feng Lu; Richard B Rothman
Opioid peptide receptor studies. 16. Chronic morphine alters G-protein function in cells expressing the cloned mu opioid receptor.
Synapse (New York, N.Y.) 2003;47(1):1-9.
2002: Richard B Rothman; Nga Vu; Heng Xu; Michael H Baumann; Yi-Feng Lu
Endogenous corticotropin releasing factor regulates adrenergic and opioid receptors.
Peptides 2002;23(12):2177-80.
2001: Heng Xu; Yi-Feng Lu; Kenner C Rice; Subramaniam Ananthan; Richard B Rothman
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
Brain research bulletin 2001;55(4):507-11.
2001: Heng Xu; Yi-Feng Lu; J B Thomas; Frank carroll; Kenner C Rice; Richard B Rothman
Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human delta-opioid receptor.
Synapse (New York, N.Y.) 2001;40(4):269-74.
2001: Heng Xu; A Hashimoto; Kenner C Rice; Arthur E Jacobson; J B Thomas; Frank carroll; J Lai; Richard B Rothman
Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [(35)S]GTP-gamma-S functional binding assay.
Synapse (New York, N.Y.) 2001;39(1):64-9.
1999: Subramaniam Ananthan; Hollis S Kezar; R L Carter; Surendra K Saini; Kenner C Rice; J L Wells; Peg Davis; Heng Xu; Christina M Dersch; Edward J Bilsky; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Journal of medicinal chemistry 1999;42(18):3527-38.
1999: Heng Xu; Yi-Feng Lu; John S Partilla; Q X Zheng; Jia Bei Wang; G A Brine; Frank carroll; Kenner C Rice; Kai-Xian Chen; Zhi-Qiang Chi; Richard B Rothman
Opioid peptide receptor studies, 11: involvement of Tyr148, Trp318 and His319 of the rat mu-opioid receptor in binding of mu-selective ligands.
Synapse (New York, N.Y.) 1999;32(1):23-8.
1998: Subramaniam Ananthan; Cheryl A Johnson; R L Carter; S D Clayton; Kenner C Rice; Heng Xu; Peg Davis; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.
Journal of medicinal chemistry 1998;41(15):2872-81.
1998: Yi-Feng Lu; Heng Xu; L Y Liu-Chen; C Chen; John S Partilla; G A Brine; Frank carroll; Kenner C Rice; J Lai; Frank Porreca; W Sadee; Richard B Rothman
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
Synapse (New York, N.Y.) 1998;28(2):117-24.
1998: Q Ni; Heng Xu; John S Partilla; Kenner C Rice; Dorota Matecka; S N Calderon; Frank Porreca; J Lai; Helmut Schmidhammer; Roland Krassnig; Richard B Rothman
Opioid peptide receptor studies. 9. Identification of a novel non-mu- non-delta-like opioid peptide binding site in rat brain.
Peptides 1998;19(6):1079-90.
1998: Heng Xu; Yi-Feng Lu; John S Partilla; J Pinto; S N Calderon; Dorota Matecka; Kenner C Rice; J Lai; Frank Porreca; Subramaniam Ananthan; Richard B Rothman
Opioid peptide receptor studies. 8. One of the mouse brain deltaNCX binding sites is similar to the cloned mouse opioid delta receptor: further evidence for heterogeneity of delta opioid receptors.
Peptides 1998;19(2):343-50.
1995: X Y Cha; Heng Xu; Q Ni; John S Partilla; Kenner C Rice; Dorota Matecka; S N Calderon; F Porreca; J Lai; Richard B Rothman
Opioid peptide receptor studies. 4. Antisense oligodeoxynucleotide to the delta opioid receptor delineates opioid receptor subtypes.
Regulatory peptides 1995;59(2):247-53.
1995: Richard B Rothman; Heng Xu; Jia Bei Wang; John S Partilla; H Kayakiri; Kenner C Rice; George R. Uhl
Ligand selectivity of cloned human and rat opioid mu receptors.
Synapse (New York, N.Y.) 1995;21(1):60-4.
1995: Heng Xu; Carl B Goodman; John S Partilla; Q Ni; H Kayakiri; Kenner C Rice; Richard B Rothman
6 beta-[125iodo]-3, 14-dihydroxy-17-methyl-4, 5 alpha-epoxymorphinan ([125I]IOXY-AGO): a potent and selective radioligand for opioid mu receptors.
Synapse (New York, N.Y.) 1995;19(2):105-11.
1995: Q Ni; Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; H Kayakiri; Richard B Rothman
Opioid peptide receptor studies. 3. Interaction of opioid peptides and other drugs with four subtypes of the kappa 2 receptor in guinea pig brain.
Peptides 1995;16(6):1083-95.
1995: X Y Cha; Heng Xu; Kenner C Rice; F Porreca; J Lai; S Ananthan; Richard B Rothman
Opioid peptide receptor studies. 1. Identification of a novel delta-opioid receptor binding site in rat brain membranes.
Peptides 1995;16(2):191-8.
1994: Q Ni; Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Anna Borsodi; S Hosztafi; Richard B Rothman
Dihydrocodeinone-hydrazone, dihydrocodeinone-oxime, naloxone-3-OMe-oxime, and clocinnamox fail to irreversibly inhibit opioid kappa receptor binding.
Neurochemical research 1994;19(9):1159-63.
1993: Q Ni; Heng Xu; John S Partilla; P A Stark; Frank carroll; G A Brine; Richard B Rothman
Stereochemical requirements for pseudoirreversible inhibition of opioid mu receptor binding by the 3-methylfentanyl congeners, RTI-46144 and its enantiomers: evidence for different binding domains.
Synapse (New York, N.Y.) 1993;15(4):296-306.
1993: Q Ni; Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Richard B Rothman
Selective labeling of kappa 2 opioid receptors in rat brain by [125I]IOXY: interaction of opioid peptides and other drugs with multiple kappa 2a binding sites.
Peptides 1993;14(6):1279-93.
1993: Richard B Rothman; L S Brady; Heng Xu; J B Long
Chronic intracerebroventricular infusion of the antiopioid peptide, Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), downregulates mu opioid binding sites in rat brain.
Peptides 1993;14(6):1271-7.
1993: Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Richard B Rothman
Differential binding of opioid peptides and other drugs to two subtypes of opioid delta ncx binding sites in mouse brain: further evidence for delta receptor heterogeneity.
Peptides 1993;14(5):893-907.
1993: Richard B Rothman; B Lewis; Christina M Dersch; Heng Xu; L Radesca; B R de Costa; Kenner C Rice; R B Kilburn; H C Akunne; A Pert
Identification of a GBR12935 homolog, LR1111, which is over 4,000-fold selective for the dopamine transporter, relative to serotonin and norepinephrine transporters.
Synapse (New York, N.Y.) 1993;14(1):34-9.
1993: Richard B Rothman; Heng Xu; G U Char; A Kim; B R De Costa; Kenner C Rice; D M Zimmerman
Phenylpiperidine opioid antagonists that promote weight loss in rats have high affinity for the kappa 2B (enkephalin-sensitive) binding site.
Peptides 1993;14(1):17-20.
1992: Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Richard B Rothman
Interaction of opioid peptides and other drugs with multiple delta ncx binding sites in rat brain: further evidence for heterogeneity.
Peptides 1992;13(6):1207-13.
1992: Richard B Rothman; V Bykov; B G Xue; Heng Xu; B R De Costa; Arthur E Jacobson; Kenner C Rice; J E Kleinman; L S Brady
Interaction of opioid peptides and other drugs with multiple kappa receptors in rat and human brain. Evidence for species differences.
Peptides 1992;13(5):977-87.
1992: S Kitayama; S Shimada; Heng Xu; L Markham; David M Donovan; George R. Uhl
Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7782-5.