FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Keith Brew

Research Profile

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Chemicals & Drugs

Living Beings

Cattle

Phenomena

Circular Dichroism

Procedures

Physiology

Protein Folding

Co-author Network

Publications

TOP 3
Nethaji Thiyagarajan; Percy Tumbale; Keith Brew; Michelle Lizotte-Waniewski; Tram T K Pham; Brittany Stinson; Amit Sundriyal; K Ravi Acharya
Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen.
Harinath Bahudhanapati; Sachdev S Sidhu; Yingnan Zhang; Keith Brew
Phage display of tissue inhibitor of metalloproteinases-2 (TIMP-2): identification of selective inhibitors of collagenase-1 (metalloproteinase 1 (MMP-1)).
Ying Wu; Shuo Wei; Steven R Van Doren; Keith Brew
Entropy increases from different sources support the high-affinity binding of the N-terminal inhibitory domains of tissue inhibitors of metalloproteinases to the catalytic domains of matrix metalloproteinases-1 and -3.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Keith Brew (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Nethaji Thiyagarajan; Percy Tumbale; Keith Brew; Michelle Lizotte-Waniewski; Tram T K Pham; Brittany Stinson; Amit Sundriyal; K Ravi Acharya
Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen.
Scientific reports 2012;2():940.
2011: Harinath Bahudhanapati; Sachdev S Sidhu; Yingnan Zhang; Keith Brew
Phage display of tissue inhibitor of metalloproteinases-2 (TIMP-2): identification of selective inhibitors of collagenase-1 (metalloproteinase 1 (MMP-1)).
The Journal of biological chemistry 2011;286(36):31761-70.
2011: Ying Wu; Shuo Wei; Steven R Van Doren; Keith Brew
Entropy increases from different sources support the high-affinity binding of the N-terminal inhibitory domains of tissue inhibitors of metalloproteinases to the catalytic domains of matrix metalloproteinases-1 and -3.
The Journal of biological chemistry 2011;286(19):16891-9.
2010: Keith Brew; Percy Tumbale; K Ravi Acharya
Family 6 glycosyltransferases in vertebrates and bacteria: inactivation and horizontal gene transfer may enhance mutualism between vertebrates and bacteria.
The Journal of biological chemistry 2010;285(48):37121-7.
2010: Ngee H Lim; Masahide Kashiwagi; Robert Visse; Jonathan Jones; Jan J Enghild; Keith Brew; Hideaki Nagase
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.
The Biochemical journal 2010;431(1):113-22.
2010: Keith Brew; Hideaki Nagase
The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.
Biochimica et biophysica acta 2010;1803(1):55-71.
2009: Percy Tumbale; Keith Brew
Characterization of a metal-independent CAZy family 6 glycosyltransferase from Bacteroides ovatus.
The Journal of biological chemistry 2009;284(37):25126-34.
2009: Haryati Jamaluddin; Percy Tumbale; Tyrone A Ferns; Nethaji Thiyagarajan; Keith Brew; K Ravi Acharya
Crystal structure of alpha-1,3-galactosyltransferase (alpha3GT) in a complex with p-nitrophenyl-beta-galactoside (pNPbetaGal).
Biochemical and biophysical research communications 2009;385(4):601-4.
2008: Percy Tumbale; Haryati Jamaluddin; Nethaji Thiyagarajan; K Ravi Acharya; Keith Brew
Screening a limited structure-based library identifies UDP-GalNAc-specific mutants of alpha-1,3-galactosyltransferase.
Glycobiology 2008;18(12):1036-43.
2008: Percy Tumbale; Haryati Jamaluddin; Nethaji Thiyagarajan; Keith Brew; K Ravi Acharya
Structural basis of UDP-galactose binding by alpha-1,3-galactosyltransferase (alpha3GT): role of negative charge on aspartic acid 316 in structure and activity.
Biochemistry 2008;47(33):8711-8.
2008: Janelle L Lauer-Fields; John K Whitehead; Shunzi Li; Robert P Hammer; Keith Brew; Gregg Fields
Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition.
The Journal of biological chemistry 2008;283(29):20087-95.
2008: Jonas Jacobsen; Robert Visse; Hans Peter Sørensen; Jan J Enghild; Keith Brew; Ulla M Wewer; Hideaki Nagase
Catalytic properties of ADAM12 and its domain deletion mutants.
Biochemistry 2008;47(2):537-47.
2008: Mare Cudic; Deepak A Patel; Janelle L Lauer-Fields; Keith Brew; Gregg Fields
Development of a convenient peptide-based assay for lysyl hydroxylase.
Biopolymers 2008;90(3):330-8.
2007: Benedict Crabtree; Nethaji Thiyagarajan; Stephen H Prior; Peter Wilson; Shalini Iyer; Tyrone Ferns; Robert Shapiro; Keith Brew; Vasanta Subramanian; K Ravi Acharya
Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis.
Biochemistry 2007;46(42):11810-8.
2007: Janelle L Lauer-Fields; Mare Cudic; Shuo Wei; Frank Mari; Gregg Fields; Keith Brew
Engineered sarafotoxins as tissue inhibitor of metalloproteinases-like matrix metalloproteinase inhibitors.
The Journal of biological chemistry 2007;282(37):26948-55.
2007: Asmaa B Hamze; Shuo Wei; Harinath Bahudhanapati; Smitha Kota; K Ravi Acharya; Keith Brew
Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors.
Protein science : a publication of the Protein Society 2007;16(9):1905-13.
2007: Janelle L Lauer-Fields; Keith Brew; John K Whitehead; Shunzi Li; Robert P Hammer; Gregg Fields
Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors.
Journal of the American Chemical Society 2007;129(34):10408-17.
2007: Haryati Jamaluddin; Percy Tumbale; Stephen G Withers; K Ravi Acharya; Keith Brew
Conformational changes induced by binding UDP-2F-galactose to alpha-1,3 galactosyltransferase- implications for catalysis.
Journal of molecular biology 2007;369(5):1270-81.
2007: Dmitriy Minond; Janelle L Lauer-Fields; Mare Cudic; Christopher M Overall; Duanqing Pei; Keith Brew; Marcia moss; Gregg Fields
Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences.
Biochemistry 2007;46(12):3724-33.
2007: Shalini Iyer; Shuo Wei; Keith Brew; K Ravi Acharya
Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1.
The Journal of biological chemistry 2007;282(1):364-71.
2007: Janelle L Lauer-Fields; Dmitriy Minond; Keith Brew; Gregg Fields
Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors.
Methods in molecular biology (Clifton, N.J.) 2007;386():125-66.
2006: Dmitriy Minond; Janelle L Lauer-Fields; Mare Cudic; Christopher M Overall; Duanqing Pei; Keith Brew; Robert Visse; Hideaki Nagase; Gregg Fields
The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity.
The Journal of biological chemistry 2006;281(50):38302-13.
2005: Tengjiao Cui; Shuo Wei; Keith Brew; Fenfei Leng
Energetics of binding the mammalian high mobility group protein HMGA2 to poly(dA-dT)2 and poly(dA)-poly(dT).
Journal of molecular biology 2005;352(3):629-45.
2005: Shuo Wei; Masahide Kashiwagi; Smitha Kota; Zhihong Xie; Hideaki Nagase; Keith Brew
Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme.
The Journal of biological chemistry 2005;280(38):32877-82.
2004: Yingnan Zhang; Ashlesha Deshpande; Zhihong Xie; Ramanathan Natesh; K Ravi Acharya; Keith Brew
Roles of active site tryptophans in substrate binding and catalysis by alpha-1,3 galactosyltransferase.
Glycobiology 2004;14(12):1295-302.
2004: Ana Maria Azzarolo; Keith Brew; Smitha Kota; Olga Ponomareva; Jonathan Schwartz; Claudia Zylberberg
Presence of tear lipocalin and other major proteins in lacrimal fluid of rabbits.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2004;138(2):111-7.
2003: Yingnan Zhang; Ganesh Jawahar Swaminathan; Ashlesha Deshpande; Ester Boix; Ramanathan Natesh; Zhihong Xie; K Ravi Acharya; Keith Brew
Roles of individual enzyme-substrate interactions by alpha-1,3-galactosyltransferase in catalysis and specificity.
Biochemistry 2003;42(46):13512-21.
2003: Shuo Wei; Zhihong Xie; Elena Filenova; Keith Brew
Drosophila TIMP is a potent inhibitor of MMPs and TACE: similarities in structure and function to TIMP-3.
Biochemistry 2003;42(42):12200-7.
2003: Lesley H Greene; Daizo Hamada; Stephen J Eyles; Keith Brew
Conserved signature proposed for folding in the lipocalin superfamily.
FEBS letters 2003;553(1-2):39-44.
2003: Keith Brew
Structure of human ACE gives new insights into inhibitor binding and design.
Trends in pharmacological sciences 2003;24(8):391-4.
2003: Shuo Wei; Ying Chen; Linda Chung; Hideaki Nagase; Keith Brew
Protein engineering of the tissue inhibitor of metalloproteinase 1 (TIMP-1) inhibitory domain. In search of selective matrix metalloproteinase inhibitors.
The Journal of biological chemistry 2003;278(11):9831-4.
2002: Ester Boix; Yingnan Zhang; Ganesh Jawahar Swaminathan; Keith Brew; K Ravi Acharya
Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferase.
The Journal of biological chemistry 2002;277(31):28310-8.
2001: Ester Boix; Ganesh Jawahar Swaminathan; Yingnan Zhang; Ramanathan Natesh; Keith Brew; K Ravi Acharya
Structure of UDP complex of UDP-galactose:beta-galactoside-alpha -1,3-galactosyltransferase at 1.53-A resolution reveals a conformational change in the catalytically important C terminus.
The Journal of biological chemistry 2001;276(51):48608-14.
2001: Lesley H Greene; Evangelia Chrysina; LI Irons; A C Papageorgiou; K Ravi Acharya; Keith Brew
Role of conserved residues in structure and stability: tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily.
Protein science : a publication of the Protein Society 2001;10(11):2301-16.
2001: M Kashiwagi; M Tortorella; Hideaki Nagase; Keith Brew
TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).
The Journal of biological chemistry 2001;276(16):12501-4.
2001: Ying Zhang; Peng George Wang; Keith Brew
Specificity and mechanism of metal ion activation in UDP-galactose:beta -galactoside-alpha -1,3-galactosyltransferase.
The Journal of biological chemistry 2001;276(15):11567-74.
2000: Evangelia Chrysina; Keith Brew; K Ravi Acharya
Crystal structures of apo- and holo-bovine alpha-lactalbumin at 2. 2-A resolution reveal an effect of calcium on inter-lobe interactions.
The Journal of biological chemistry 2000;275(47):37021-9.
2000: WH Yu; S Yu; Qing Meng; Keith Brew; J Fred Woessner
TIMP-3 binds to sulfated glycosaminoglycans of the extracellular matrix.
The Journal of biological chemistry 2000;275(40):31226-32.
2000: Keith Brew; Deendayal Dinakarpandian; Hideaki Nagase
Tissue inhibitors of metalloproteinases: evolution, structure and function.
Biochimica et biophysica acta 2000;1477(1-2):267-83.
1999: Ying Zhang; VA Malinovskii; Tristan J Fiedler; Keith Brew
Role of a conserved acidic cluster in bovine beta1,4 galactosyltransferase-1 probed by mutagenesis of a bacterially expressed recombinant enzyme.
Glycobiology 1999;9(8):815-22.
1999: Lesley H Greene; J A Grobler; VA Malinovskii; J Tian; K Ravi Acharya; Keith Brew
Stability, activity and flexibility in alpha-lactalbumin.
Protein engineering 1999;12(7):581-7.
1999: Hideaki Nagase; Qing Meng; VA Malinovskii; Wei Huang; Linda Chung; Wolfram Bode; Klaus Maskos; Keith Brew
Engineering of selective TIMPs.
Annals of the New York Academy of Sciences 1999;878():1-11.
1999: Qing Meng; VA Malinovskii; Wei Huang; Y Hu; Linda Chung; Hideaki Nagase; Wolfram Bode; Klaus Maskos; Keith Brew
Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1' residue of substrate.
The Journal of biological chemistry 1999;274(15):10184-9.
1998: N Chandra; Keith Brew; K Ravi Acharya
Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin.
Biochemistry 1998;37(14):4767-72.
1998: Kazushi Suzuki; CC Kan; Wesley Hung; MR Gehring; Keith Brew; Hideaki Nagase
Expression of human pro-matrix metalloproteinase 3 that lacks the N-terminal 34 residues in Escherichia coli: autoactivation and interaction with tissue inhibitor of metalloproteinase 1 (TIMP-1).
Biological chemistry 1998;379(2):185-91.
1997: FX Gomis-Rüth; Klaus Maskos; M Betz; Albrecht Bergner; Robert Huber; K Suzuki; N Yoshida; Hideaki Nagase; Keith Brew; Gleb P Bourenkov; Hans D Bartunik; Wolfram Bode
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.
Nature 1997;389(6646):77-81.
1997: Wei Huang; Qing Meng; Kazushi Suzuki; Hideaki Nagase; Keith Brew
Mutational study of the amino-terminal domain of human tissue inhibitor of metalloproteinases 1 (TIMP-1) locates an inhibitory region for matrix metalloproteinases.
The Journal of biological chemistry 1997;272(35):22086-91.
1997: Hideaki Nagase; Kazushi Suzuki; T E Cawston; Keith Brew
Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1).
The Biochemical journal 1997;325 ( Pt 1)():163-7.
1996: VA Malinovskii; J Tian; J A Grobler; Keith Brew
Functional site in alpha-lactalbumin encompasses a region corresponding to a subsite in lysozyme and parts of two adjacent flexible substructures.
Biochemistry 1996;35(30):9710-5.
1996: A C Pike; Keith Brew; K Ravi Acharya
Crystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase.
Structure (London, England : 1993) 1996;4(6):691-703.
1996: J Zhang; Zhongjian Zhang; Keith Brew; E Y Lee
Mutational analysis of the catalytic subunit of muscle protein phosphatase-1.
Biochemistry 1996;35(20):6276-82.
1996: Wei Huang; Kazushi Suzuki; Hideaki Nagase; S Arumugam; Steven R Van Doren; Keith Brew
Folding and characterization of the amino-terminal domain of human tissue inhibitor of metalloproteinases-1 (TIMP-1) expressed at high yield in E. coli.
FEBS letters 1996;384(2):155-61.
1996: Hideaki Nagase; Kazushi Suzuki; Yoshifumi Itoh; CC Kan; M R Gehring; Wei Huang; Keith Brew
Involvement of tissue inhibitors of metalloproteinases (TIMPS) during matrix metalloproteinase activation.
Advances in experimental medicine and biology 1996;389():23-31.
1994: S P Yadav; Keith Brew; J David Puett
Holoprotein formation of human chorionic gonadotropin: differential trace labeling with acetic anhydride.
Molecular endocrinology (Baltimore, Md.) 1994;8(11):1547-58.
1994: J A Grobler; K R Rao; S Pervaiz; Keith Brew
Sequences of two highly divergent canine type c lysozymes: implications for the evolutionary origins of the lysozyme/alpha-lactalbumin superfamily.
Archives of biochemistry and biophysics 1994;313(2):360-6.
1994: J A Grobler; M Wang; A C Pike; Keith Brew
Study by mutagenesis of the roles of two aromatic clusters of alpha-lactalbumin in aspects of its action in the lactose synthase system.
The Journal of biological chemistry 1994;269(7):5106-14.
1994: S P Yadav; Keith Brew; M H Majercik; J David Puett
A label selection approach to assess the role of individual amino groups in human choriogonadotropin receptor binding.
The Journal of biological chemistry 1994;269(6):3991-8.
1991: S P Yadav; Keith Brew
Structure and function in galactosyltransferase. Sequence locations of alpha-lactalbumin binding site, thiol groups, and disulfide bond.
The Journal of biological chemistry 1991;266(2):698-703.
1990: J Zeng; K R Rao; Keith Brew; Roger Fenna
Crystallization of a calcium-binding lysozyme from horse milk.
The Journal of biological chemistry 1990;265(25):14886-7.
1990: S Yadav; Keith Brew
Identification of a region of UDP-galactose:N-acetylglucosamine beta 4-galactosyltransferase involved in UDP-galactose binding by differential labeling.
The Journal of biological chemistry 1990;265(24):14163-9.
1989: M Wang; Walter A Scott; K R Rao; J Udey; Gregory Conner; Keith Brew
Recombinant bovine alpha-lactalbumin obtained by limited proteolysis of a fusion protein expressed at high levels in Escherichia coli.
The Journal of biological chemistry 1989;264(35):21116-21.
1989: K R Rao; Keith Brew
Calcium regulates folding and disulfide-bond formation in alpha-lactalbumin.
Biochemical and biophysical research communications 1989;163(3):1390-6.
1989: D Chin; Keith Brew
Effects of modifying individual amino or carboxyl groups on the affinity of calmodulin for calcineurin.
The Journal of biological chemistry 1989;264(26):15367-75.
1989: L M Babé; Keith Brew; S E Matsuura; Walter A Scott
Epitopes on the major capsid protein of simian virus 40.
The Journal of biological chemistry 1989;264(5):2665-71.
1988: Qun Wei; A E Jackson; S Pervaiz; K L Carraway; E Y Lee; J David Puett; Keith Brew
Effects of interaction with calcineurin on the reactivities of calmodulin lysines.
The Journal of biological chemistry 1988;263(36):19541-4.
1987: Hideaki Nagase; Keith Brew
Amino acid sequence of a 32-residue region around the thiol ester site in duck ovostatin.
FEBS letters 1987;222(1):83-8.
1987: S Pervaiz; Keith Brew
Homology and structure-function correlations between alpha 1-acid glycoprotein and serum retinol-binding protein and its relatives.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1987;1(3):209-14.
1987: A E Jackson; K L Carraway; M E Payne; A R Means; J David Puett; Keith Brew
Association of calmodulin and smooth muscle myosin light chain kinase: application of a label selection technique with trace acetylated calmodulin.
Proteins 1987;2(3):202-9.
1986: A E Jackson; K L Carraway; J David Puett; Keith Brew
Effects of the binding of myosin light chain kinase on the reactivities of calmodulin lysines.
The Journal of biological chemistry 1986;261(26):12226-32.
1986: S Pervaiz; Keith Brew
Purification and characterization of the major whey proteins from the milks of the bottlenose dolphin (Tursiops truncatus), the Florida manatee (Trichechus manatus latirostris), and the beagle (Canis familiaris).
Archives of biochemistry and biophysics 1986;246(2):846-54.
1986: S Pervaiz; Keith Brew
Composition of the milks of the bottlenose dolphin (Tursiops trucatus) and the Florida manatee (Trichechus manatus latirostris).
Comparative biochemistry and physiology. A, Comparative physiology 1986;84(2):357-60.
1985: S Pervaiz; Keith Brew
Homology of beta-lactoglobulin, serum retinol-binding protein, and protein HC.
Science (New York, N.Y.) 1985;228(4697):335-7.