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Yan Xu

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Hailan Liu; Zhiyong Luo; Xi Wu; Yan Xu; Zizheng Dong; Zhenwen Zhao; Jian-Ting Zhang
Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production.
Hui Cai; Yan Xu
The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells.
Hui Cai; Elena G Chiorean; Michael V Chiorean; Noah M Hahn; Marietta L Harrison; Ziyue Liu; Patrick J Loehrer; Douglas K Rex; Bruce W Robb; Yan Xu
Elevated phospholipase A2 activities in plasma samples from multiple cancers.

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All Publications

2013: Hailan Liu; Zhiyong Luo; Xi Wu; Yan Xu; Zizheng Dong; Zhenwen Zhao; Jian-Ting Zhang
Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production.
Journal of lipid research 2013;54(3):776-85.
2013: Hui Cai; Yan Xu
The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells.
Cell communication and signaling : CCS 2013;11(1):31.
2013: Hui Cai; Elena G Chiorean; Michael V Chiorean; Noah M Hahn; Marietta L Harrison; Ziyue Liu; Patrick J Loehrer; Douglas K Rex; Bruce W Robb; Yan Xu
Elevated phospholipase A2 activities in plasma samples from multiple cancers.
PloS one 2013;8(2):e57081.
2012: Qingchun Cai; Giuseppe Del Priore; Ali Hassan Hamed; Jeanne M Schilder; Frederick B Stehman; Libo Yan; Zhenwen Zhao; Caryl Antalis; Yan Xu
Elevated and secreted phospholipase A₂ activities as new potential therapeutic targets in human epithelial ovarian cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(8):3306-20.
2011: Hui Li; Gang Wei; Caryl Antalis; Robert Emerson; Sheng Zhang; Zhong-Yin Zhang; Zhenwen Zhao; Zhanzhong Zhao; Yan Xu
Combination therapy of an inhibitor of group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development.
The American journal of pathology 2011;179(1):452-61.
2011: Hui Li; Hong Zhang; Gang Wei; Qingchun Cai; Libo Yan; Yan Xu
Tumor cell group via phospholipase A₂ is involved in prostate cancer development.
The Prostate 2011;71(4):373-84.
2011: Zhenwen Zhao; Menggang Yu; David Crabb; Yan Xu; Suthat Liangpunsakul
Ethanol-induced alterations in fatty acid-related lipids in serum and tissues in mice.
Alcoholism, clinical and experimental research 2011;35(2):229-34.
2010: Hui Li; Zhenwen Zhao; Gang Wei; Libo Yan; Dongmei Wang; Hong Zhang; George Earl Sandusky; John Turk; Yan Xu
Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(10):4103-16.
2010: Zhenwen Zhao; Yan Xu
An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples.
Journal of lipid research 2010;51(3):652-9.
2010: Jian-Min Wu; Yan Xu; Nicholas Skill; Hongmiao Sheng; Zhenwen Zhao; Menggang Yu; Romil Saxena; Mary A Maluccio
Autotaxin expression and its connection with the TNF-alpha-NF-kappaB axis in human hepatocellular carcinoma.
Molecular cancer 2010;9():71.
2009: Zhenwen Zhao; Yan Xu
Measurement of endogenous lysophosphatidic acid by ESI-MS/MS in plasma samples requires pre-separation of lysophosphatidylcholine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(29):3739-42.
2009: Hui Li; Dongmei Wang; Hong Zhang; Kashif Kirmani; Zhenwen Zhao; Rosemary Steinmetz; Yan Xu
Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice.
Molecular cancer therapeutics 2009;8(6):1692-701.
2009: Yan Xu; Dongmei Wang; Zeneng Wang
Lipid generation and signaling in ovarian cancer.
Cancer treatment and research 2009;149():241-67.
2009: Hui Li; Dongmei Wang; Shanjukumar Lisam; Michael Berk; Haiyan Tan; Zhenwen Zhao; Rosemary Steinmetz; Kashif Kirmani; Gang Wei; Yan Xu
Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1.
PloS one 2009;4(5):e5705.
2008: Dongmei Wang; Zhenwen Zhao; Andrea Caperell-Grant; Gong Yang; Samuel C Mok; Jinsong Liu; Robert M Bigsby; Yan Xu
S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells.
Molecular cancer therapeutics 2008;7(7):1993-2002.
2007: Shanjukumar Lisam; Michael Berk; Rhonda Oates; Zhenwen Zhao; Haiyan Tan; Ying Jiang; Aimin Zhou; Kashif Kirmani; Rosemary Steinmetz; Daniel J Lindner; Yan Xu
Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer.
Journal of the National Cancer Institute 2007;99(17):1313-27.
2007: Zhenwen Zhao; Yijin Xiao; Paul Elson; Haiyan Tan; Sarah J Plummer; Michael Berk; Phyu P Aung; Ian C Lavery; Jean-Paul Achkar; Li Li; Graham Casey; Yan Xu
Plasma lysophosphatidylcholine levels: potential biomarkers for colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(19):2696-701.
2007: Saubhik Sengupta; Kwan-Sik Kim; M P Berk; Rhonda K Oates; Pedro F Escobar; Jerome Belinson; W Li; Daniel J Lindner; B Williams; Yan Xu
Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion.
Oncogene 2007;26(20):2894-901.
2006: Alexander Zaslavsky; Shanjukumar Lisam; Haiyan Tan; Huawen Ding; Zicai Liang; Yan Xu
Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4.
Biochimica et biophysica acta 2006;1761(10):1200-12.
2006: Xiaoxian Zhao; Dongmei Wang; Zhenwen Zhao; Yingyi Xiao; Saubhik Sengupta; Yijin Xiao; Renliang Zhang; Kirsten Lauber; Sebastian Wesselborg; Li Feng; Tyler M Rose; Yue Shen; Junjie Zhang; Glenn Prestwich; Yan Xu
Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells.
The Journal of biological chemistry 2006;281(39):29357-68.
2006: Kwan-Sik Kim; Saubhik Sengupta; Michael Berk; Yong-Geun Kwak; Pedro F Escobar; Jerome Belinson; Samuel C Mok; Yan Xu
Hypoxia enhances lysophosphatidic acid responsiveness in ovarian cancer cells and lysophosphatidic acid induces ovarian tumor metastasis in vivo.
Cancer research 2006;66(16):7983-90.
2006: Juan Ren; Yi-jin Xiao; Shanjukumar Lisam; Xiaoxian Zhao; Zhenwen Zhao; Li Feng; Tyler M Rose; Glenn D Prestwich; Yan Xu
Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells.
Cancer research 2006;66(6):3006-14.
2005: Alexander Zaslavsky; Song Li; Yan Xu
Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells.
FEBS letters 2005;579(18):3899-906.
2005: Kwan-Sik Kim; Juan Ren; Ying Jiang; Quteba Ebrahem; Russell Tipps; Kelly L Cristina; Yi-jin Xiao; Jing Qiao; Kevin L Taylor; Hazel Lum; Bela Anand-Apte; Yan Xu
GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):819-21.
2005: Owen N Witte; Janusz H S Kabarowski; Yan Xu; Lu Q Le; Kui Zhu
Retraction.
Science (New York, N.Y.) 2005;307(5707):206.
2005: Ying Jiang; Michael Berk; Shanjukumar Lisam; Haiyan Tan; Lihong Yin; C Thomas Powell; Yan Xu
KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha.
Clinical & experimental metastasis 2005;22(5):369-76.
2004: Saubhik Sengupta; Zeneng Wang; Russell Tipps; Yan Xu
Biology of LPA in health and disease.
Seminars in cell & developmental biology 2004;15(5):503-12.
2004: Linnea M Baudhuin; Ying Jiang; Alexander Zaslavsky; Isao Ishii; Jerold Chun; Yan Xu
S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):341-3.
2003: Saubhik Sengupta; Yi-jin Xiao; Yan Xu
A novel laminin-induced LPA autocrine loop in the migration of ovarian cancer cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1570-2.
2003: Yan Xu; Yi-jin Xiao; Kui Zhu; Linnea M Baudhuin; Jun Lu; Guiying Hong; Kwan-Sik Kim; Kelly L Cristina; Li Song; Freager S Williams; Paul Elson; Maurie Markman; Jerome Belinson
Unfolding the pathophysiological role of bioactive lysophospholipids.
Current drug targets. Immune, endocrine and metabolic disorders 2003;3(1):23-32.
2002: Linnea M Baudhuin; Kelly L Cristina; Jun Lu; Yan Xu
Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific.
Molecular pharmacology 2002;62(3):660-71.
2002: Janusz H S Kabarowski; Yan Xu; Owen N Witte
Lysophosphatidylcholine as a ligand for immunoregulation.
Biochemical pharmacology 2002;64(2):161-7.
2002: Yan Xu
Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction.
Biochimica et biophysica acta 2002;1582(1-3):81-8.
2002: Jun Lu; Yi-jin Xiao Yj; Linnea M Baudhuin; Guiying Hong; Yan Xu
Role of ether-linked lysophosphatidic acids in ovarian cancer cells.
Journal of lipid research 2002;43(3):463-76.
2001: Keng Zhu; Linnea M Baudhuin; Guiying Hong; F S Williams; Kelly L Cristina; Janusz H S Kabarowski; Owen N Witte; Yan Xu
Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.
The Journal of biological chemistry 2001;276(44):41325-35.
2001: Z Shen; M Wu; Paul Elson; Alexander W Kennedy; Jerome Belinson; Graham Casey; Yan Xu
Fatty acid composition of lysophosphatidic acid and lysophosphatidylinositol in plasma from patients with ovarian cancer and other gynecological diseases.
Gynecologic oncology 2001;83(1):25-30.
2001: Janusz H S Kabarowski; Keng Zhu; Lu Q Le; Owen N Witte; Yan Xu
Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.
Science (New York, N.Y.) 2001;293(5530):702-5.
2001: B M Schwartz; Guiying Hong; B H Morrison; W Wu; Linnea M Baudhuin; Yi-jin Xiao; S C Mok; Yan Xu
Lysophospholipids increase interleukin-8 expression in ovarian cancer cells.
Gynecologic oncology 2001;81(2):291-300.
2001: Yi-jin Xiao; B Schwartz; M Washington; A Kennedy; K Webster; Jerome Belinson; Yan Xu
Electrospray ionization mass spectrometry analysis of lysophospholipids in human ascitic fluids: comparison of the lysophospholipid contents in malignant vs nonmalignant ascitic fluids.
Analytical biochemistry 2001;290(2):302-13.
2001: H Xue; Robeena Aziz; N Sun; J M Cassady; Lisa M Kamendulis; Yan Xu; Gary D Stoner; James Klaunig
Inhibition of cellular transformation by berry extracts.
Carcinogenesis 2001;22(2):351-6.
2001: Yan Xu; Yi-jin Xiao; Linnea M Baudhuin; B M Schwartz
The role and clinical applications of bioactive lysolipids in ovarian cancer.
Journal of the Society for Gynecologic Investigation 2001;8(1):1-13.
2000: Haizhou Zhang; Yan Xu; Lisa M Kamendulis; James Klaunig
Morphological transformation by 8-hydroxy-2'-deoxyguanosine in Syrian hamster embryo (SHE) cells.
Toxicological sciences : an official journal of the Society of Toxicology 2000;56(2):303-12.
2000: D Nugent; Yan Xu
Sphingosine-1-phosphate: characterization of its inhibition of platelet aggregation.
Platelets 2000;11(4):226-32.
2000: Yan Xu; Keng Zhu; Guiying Hong; W Wu; Linnea M Baudhuin; Y Xiao; D S Damron
Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.
Nature cell biology 2000;2(5):261-7.
2000: Y Xiao; Y Chen; Alexander W Kennedy; Jerome Belinson; Yan Xu
Evaluation of plasma lysophospholipids for diagnostic significance using electrospray ionization mass spectrometry (ESI-MS) analyses.
Annals of the New York Academy of Sciences 2000;905():242-59.
2000: Haizhou Zhang; Lisa M Kamendulis; J Jiang; Yan Xu; James Klaunig
Acrylonitrile-induced morphological transformation in Syrian hamster embryo cells.
Carcinogenesis 2000;21(4):727-33.
1999: Guiying Hong; Linnea M Baudhuin; Yan Xu
Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells.
FEBS letters 1999;460(3):513-8.
1999: Donald E Stevenson; Earl F Walborg; D W North; Robert L Sielken; C E Ross; A S Wright; Yan Xu; Lisa M Kamendulis; James Klaunig
Monograph: reassessment of human cancer risk of aldrin/dieldrin.
Toxicology letters 1999;109(3):123-86.
1999: Lisa M Kamendulis; J Jiang; Yan Xu; James Klaunig
Induction of oxidative stress and oxidative damage in rat glial cells by acrylonitrile.
Carcinogenesis 1999;20(8):1555-60.
1999: Debomoy K Lahiri; Yan Xu; James Klaunig; Olusegun Baiyewu; Adesola Ogunniyi; K Hall; Hugh Hendrie; Amrik Sahota
Effect of oxidative stress on DNA damage and beta-amyloid precursor proteins in lymphoblastoid cell lines from a Nigerian population.
Annals of the New York Academy of Sciences 1999;893():331-6.
1998: J Jiang; Yan Xu; James Klaunig
Induction of oxidative stress in rat brain by acrylonitrile (ACN).
Toxicological sciences : an official journal of the Society of Toxicology 1998;46(2):333-41.
1998: Z Shen; Jerome Belinson; Richard E Morton; Yan Xu; Y Xu
Phorbol 12-myristate 13-acetate stimulates lysophosphatidic acid secretion from ovarian and cervical cancer cells but not from breast or leukemia cells.
Gynecologic oncology 1998;71(3):364-8.
1998: Yan Xu; Z Shen; D W Wiper; M Wu; Richard E Morton; Paul Elson; Alexander W Kennedy; Jerome Belinson; Maurie Markman; Graham Casey
Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers.
JAMA : the journal of the American Medical Association 1998;280(8):719-23.
1998: S Bachowski; Yan Xu; Donald E Stevenson; Earl F Walborg; James Klaunig
Role of oxidative stress in the selective toxicity of dieldrin in the mouse liver.
Toxicology and applied pharmacology 1998;150(2):301-9.
1998: Kolaja Kyle; Yan Xu; Earl F Walborg; Donald E Stevenson; James Klaunig
Vitamin E modulation of dieldrin-induced hepatic focal lesion growth in mice.
Journal of toxicology and environmental health. Part A 1998;53(6):479-92.
1998: James Klaunig; Yan Xu; Jason S Isenberg; S Bachowski; Kolaja Kyle; J Jiang; Donald E Stevenson; Earl F Walborg
The role of oxidative stress in chemical carcinogenesis.
Environmental health perspectives 1998;106 Suppl 1():289-95.
1997: S Bachowski; Kolaja Kyle; Yan Xu; C A Ketcham; Donald E Stevenson; Earl F Walborg; James Klaunig
Role of oxidative stress in the mechanism of dieldrin's hepatotoxicity.
Annals of clinical and laboratory science 1997;27(3):196-209.
1996: J Cao; Yan Xu; J Chen; James Klaunig
Chemopreventive effects of green and black tea on pulmonary and hepatic carcinogenesis.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;29(2):244-50.
1995: James Klaunig; Yan Xu; S Bachowski; C A Ketcham; Jason S Isenberg; Kolaja Kyle; T K Baker; Earl F Walborg; Donald E Stevenson
Oxidative stress in nongenotoxic carcinogenesis.
Toxicology letters 1995;82-83():683-91.
1995: Yan Xu; X J Fang; G Casey; G B Mills
Lysophospholipids activate ovarian and breast cancer cells.
The Biochemical journal 1995;309 ( Pt 3)():933-40.
1995: Yan Xu; G Casey; G B Mills
Effect of lysophospholipids on signaling in the human Jurkat T cell line.
Journal of cellular physiology 1995;163(3):441-50.
1995: S Bachowski; Yan Xu; T K Baker; Donald E Stevenson; Earl F Walborg; James Klaunig
The potential role of oxidative stress in nongenotoxic carcinogenesis in the mouse liver.
Progress in clinical and biological research 1995;391():385-96.