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Zhenming Xu

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TOP 3
Hong Zan; Jinsong Zhang; Guideng Li; Thach Mai; Lisa M Thomas; Clayton A White; Zhenming Xu; Paolo Casali
Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.
Zhenming Xu; Hong Zan; Thach Mai; Egest J Pone; Paolo Casali
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.
Guideng Li; Pina J Patel; Egest J Pone; Daniel C Tran; Zhenming Xu; Lisa Dao; Paolo Casali
Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination.

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All Publications

2012: Hong Zan; Jinsong Zhang; Guideng Li; Thach Mai; Lisa M Thomas; Clayton A White; Zhenming Xu; Paolo Casali
Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.
Cell reports 2012;2(5):1220-32.
2012: Zhenming Xu; Hong Zan; Thach Mai; Egest J Pone; Paolo Casali
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.
Nature reviews. Immunology 2012;12(7):517-31.
2012: Guideng Li; Pina J Patel; Egest J Pone; Daniel C Tran; Zhenming Xu; Lisa Dao; Paolo Casali
Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination.
The Journal of biological chemistry 2012;287(25):21520-9.
2012: Egest J Pone; Clayton A White; Zhenming Xu; Hong Zan; Paolo Casali
B cell TLRs and induction of immunoglobulin class-switch DNA recombination.
Frontiers in bioscience : a journal and virtual library 2012;17():2594-615.
2012: Egest J Pone; John K Sakakura; Clayton A White; Zhenming Xu; Hong Zan; Jinsong Zhang; Ahmed Al-Qahtani; Guideng Li; Thach Mai; Pina J Patel; Paolo Casali
BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway.
Nature communications 2012;3():767.
2010: Zhenming Xu; Zsolt Fulop; Guikai Wu; Egest J Pone; Jinsong Zhang; Thach Mai; Lisa M Thomas; Ahmed Al-Qahtani; Clayton A White; Seok-Rae Park; Petra Steinacker; Zenggang Li; John Yates; Bruce Herron; Markus Otto; Hong Zan; Haian Fu; Paolo Casali
14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.
Nature structural & molecular biology 2010;17(9):1124-35.
2010: Egest J Pone; Hong Zan; Jingsong Zhang; Ahmed Al-Qahtani; Zhenming Xu; Paolo Casali
Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses.
Critical reviews in immunology 2010;30(1):1-29.
2009: Seok-Rae Park; Hong Zan; Zsuzsanna Pal; Jinsong Zhang; Ahmed Al-Qahtani; Egest J Pone; Zhenming Xu; Thach Mai; Paolo Casali
HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.
Nature immunology 2009;10(5):540-50.
2009: Hong Zan; Jinsong Zhang; Sona Ardeshna; Zhenming Xu; Seok-Rae Park; Paolo Casali
Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.
Autoimmunity 2009;42(2):89-103.
2008: Ahmed Al-Qahtani; Zhenming Xu; Hong Zan; Craig M Walsh; Paolo Casali
A role for DRAK2 in the germinal center reaction and the antibody response.
Autoimmunity 2008;41(5):341-52.
2007: Zhenming Xu; Egest J Pone; Ahmed Al-Qahtani; Seok-Rae Park; Hong Zan; Paolo Casali
Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination.
Critical reviews in immunology 2007;27(4):367-97.
2007: Zhenming Xu; Hong Zan; Zsuzsanna Pal; Paolo Casali
DNA replication to aid somatic hypermutation.
Advances in experimental medicine and biology 2007;596():111-27.
2006: Paolo Casali; Zsuzsanna Pal; Zhenming Xu; Hong Zan
DNA repair in antibody somatic hypermutation.
Trends in immunology 2006;27(7):313-21.
2006: Atsumasa Komori; Zhenming Xu; Xiaoping Wu; Hong Zan; Paolo Casali
Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells.
Molecular immunology 2006;43(11):1817-26.
2005: Hong Zan; Naoko Shima; Zhenming Xu; Ahmed Al-Qahtani; Albert J Evinger Iii; Yuan Zhong; John C Schimenti; Paolo Casali
The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation.
The EMBO journal 2005;24(21):3757-69.
2005: Zhenming Xu; Zsolt Fulop; Yuan Zhong; Albert J Evinger; Hong Zan; Paolo Casali
DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.
Annals of the New York Academy of Sciences 2005;1050():146-62.