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Richard Breyer

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Jason D Downey; Craig W Lindsley; Ryan D Morrison; Sam A Saleh; J Scott Daniels; Thomas M Bridges; Richard M Breyer
Development of an in vivo active, dual EP1 and EP3 selective antagonist based on a novel acyl sulfonamide bioisostere.
Chandramohan Natarajan; Roy Zent; Heidi E Hamm; Aaron N Hata; Richard M Breyer
Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor.
Christina S Bartlett; Kelli L Boyd; Raymond C Harris; Roy Zent; Richard M Breyer
EP1 disruption attenuates end-organ damage in a mouse model of hypertension.

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All Publications

2013: Jason D Downey; Craig W Lindsley; Ryan D Morrison; Sam A Saleh; J Scott Daniels; Thomas M Bridges; Richard M Breyer
Development of an in vivo active, dual EP1 and EP3 selective antagonist based on a novel acyl sulfonamide bioisostere.
Bioorganic & medicinal chemistry letters 2013;23(1):37-41.
2013: Chandramohan Natarajan; Roy Zent; Heidi E Hamm; Aaron N Hata; Richard M Breyer
Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor.
Molecular pharmacology 2013;83(1):206-16.
2012: Christina S Bartlett; Kelli L Boyd; Raymond C Harris; Roy Zent; Richard M Breyer
EP1 disruption attenuates end-organ damage in a mouse model of hypertension.
Hypertension 2012;60(5):1184-91.
2012: Weisong Zhou; Subramaniam Sriram; Shinji Toki; Pingsheng Wu; Songyi Yao; Huiyong Yin; Madison G Boswell; Richard M Breyer; Dustin R Dowell; Garret A Fitzgerald; Kasia Goleniewska; Matthew M Huckabee; Matthew T Lotz; Chandramohan Natarajan; Dawn C Newcomb; R Stokes Peebles
Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis.
PloS one 2012;7(5):e33518.
2011: Christina E Swan; Richard M Breyer
Prostaglandin E2 modulation of blood pressure homeostasis: studies in rodent models.
Prostaglandins & other lipid mediators 2011;96(1-4):10-3.
2011: Jason D Downey; Charles R Sanders; Richard M Breyer
Evidence for the presence of a critical disulfide bond in the mouse EP3γ receptor.
Prostaglandins & other lipid mediators 2011;94(1-2):53-8.
2010: James P Smith; Elias V Haddad; Jason D Downey; Richard M Breyer; Olivier Boutaud
PGE2 decreases reactivity of human platelets by activating EP2 and EP4.
Thrombosis research 2010;126(1):e23-9.
2008: Vladimir R Babaev; Joshua D Chew; Lei Ding; Sarah Davis; Matthew D Breyer; Richard M Breyer; John A Oates; Sergio Fazio; MacRae F Linton
Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis.
Cell metabolism 2008;8(6):492-501.
2008: Ines Macias-Perez; Roy Zent; Monica Carmosino; Matthew D Breyer; Richard M Breyer; Ambra Pozzi
Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo.
The Journal of biological chemistry 2008;283(18):12538-45.
2007: Youfei Guan; Yahua Zhang; Jing Wu; Zhonghua Qi; Guangrui Yang; Dou Dou; Yuansheng Gao; Lihong Chen; Xiaoyan Zhang; Linda S Davis; Mingfeng Wei; Xuefeng Fan; Monica Carmosino; Chuanming Hao; John D Imig; Richard M Breyer; Matthew D Breyer
Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.
The Journal of clinical investigation 2007;117(9):2496-505.
2007: Weisong Zhou; Timothy S Blackwell; Kasia Goleniewska; Jamye F O'Neal; garret fitzgerald; Margaret Lucitt; Richard M Breyer; R Stokes Peebles
Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells.
Journal of leukocyte biology 2007;81(3):809-17.
2006: M Kamiyama; Ambra Pozzi; Li Yang; Laura M DeBusk; Richard M Breyer; P Charles Lin
EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival.
Oncogene 2006;25(53):7019-28.
2006: Svetlana Pavlovic; Baoheng Du; Kazuko Sakamoto; K M Faisal Khan; Chandramohan Natarajan; Richard M Breyer; Andrew J Dannenberg; Domenick J Falcone
Targeting prostaglandin E2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages.
The Journal of biological chemistry 2006;281(6):3321-8.
2005: Richard L Hébert; Monica Carmosino; Osamu Saito; Guangrui Yang; Cynthia A Jackson; Zhonghua Qi; Richard M Breyer; Chandramohan Natarajan; Aaron N Hata; Yahua Zhang; Youfei Guan; Matthew D Breyer
Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct.
The Journal of biological chemistry 2005;280(41):35028-37.
2005: Aaron N Hata; Terry P Lybrand; Richard M Breyer
Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2.
The Journal of biological chemistry 2005;280(37):32442-51.
2005: Changlin Tian; Richard M Breyer; Hak Jun Kim; Murthy D Karra; David B Friedman; Anne Karpay; Charles R Sanders
Solution NMR spectroscopy of the human vasopressin V2 receptor, a G protein-coupled receptor.
Journal of the American Chemical Society 2005;127(22):8010-1.
2005: Aaron N Hata; Terry P Lybrand; Lawrence J Marnett; Richard M Breyer
Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2.
Molecular pharmacology 2005;67(3):640-7.
2004: André Schneider; Youfei Guan; Yahua Zhang; Mark Magnuson; Cathy Pettepher; Charles D Loftin; Robert Langenbach; Richard M Breyer; Matthew D Breyer
Generation of a conditional allele of the mouse prostaglandin EP4 receptor.
Genesis (New York, N.Y. : 2000) 2004;40(1):7-14.
2004: Aaron N Hata; Richard M Breyer
Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation.
Pharmacology & therapeutics 2004;103(2):147-66.
2004: Ambra Pozzi; Xuexian Yan; Ines Macias-Perez; Shouzuo Wei; Aaron N Hata; Richard M Breyer; Jason D Morrow; Jorge H Capdevila
Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation.
The Journal of biological chemistry 2004;279(28):29797-804.
2004: André Schneider; YaHua Zhang; Mingzhi Zhang; Wendell J Lu; Reena Rao; Xuefeng Fan; Reyadh Redha; Linda Davis; Richard M Breyer; Raymond Harris; Youfei Guan; Matthew D Breyer
Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney.
Kidney international 2004;65(4):1205-13.
2003: Matthew D Breyer; Richard L Hébert; Richard M Breyer
Prostanoid receptors and the urogenital tract.
Current opinion in investigational drugs (London, England : 2000) 2003;4(11):1343-53.
2003: YaHua Zhang; André Schneider; Reena Rao; Wendell J Lu; XueFeng Fan; Linda Davis; Richard M Breyer; Matthew D Breyer; Youfei Guan
Genomic structure and genitourinary expression of mouse cytosolic prostaglandin E(2) synthase gene.
Biochimica et biophysica acta 2003;1634(1-2):15-23.
2003: Aaron N Hata; Roy Zent; Matthew D Breyer; Richard M Breyer
Expression and molecular pharmacology of the mouse CRTH2 receptor.
The Journal of pharmacology and experimental therapeutics 2003;306(2):463-70.
2003: Osamu Saito; Youfei Guan; Zhonghua Qi; Linda S Davis; Martin Kömhoff; Yukihiko Sugimoto; Shuh Narumiya; Richard M Breyer; Matthew D Breyer
Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract.
American journal of physiology. Renal physiology 2003;284(6):F1164-70.
2003: Li Yang; Noboru Yamagata; Rajwardhan Yadav; Suzanne Brandon; Regina L Courtney; Jason D Morrow; Yu Shyr; Mark Boothby; Sebastian JOYCE; David P Carbone; Richard M Breyer
Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor.
The Journal of clinical investigation 2003;111(5):727-35.
2002: Thomas J Montine; Dejan Milatovic; Ramesh C Gupta; Tibor Valyi-Nagy; Jason D Morrow; Richard M Breyer
Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent.
Journal of neurochemistry 2002;83(2):463-70.
2002: Hui-Fang Cheng; Sue-Wan Wang; Ming-Zhi Zhang; James A McKanna; Richard M Breyer; Raymond C Harris
Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(3):R638-46.
2002: Zhonghua Qi; Chuan-Ming Hao; Robert Langenbach; Richard M Breyer; Reyadh Redha; Jason D Morrow; Matthew D Breyer
Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II.
The Journal of clinical investigation 2002;110(1):61-9.
2002: Youfei Guan; Brett A Stillman; Yahua Zhang; André Schneider; Osamu Saito; Linda S Davis; Reyadh Redha; Richard M Breyer; Matthew D Breyer
Cloning and expression of the rabbit prostaglandin EP2 receptor.
BMC pharmacology 2002;2():14.
2002: Richard M Breyer; Christopher R J Kennedy; Yahua Zhang; Youfei Guan; Matthew D Breyer
Targeted gene disruption of the prostaglandin E2 EP2 receptor.
Advances in experimental medicine and biology 2002;507():321-6.
2001: Youfei Guan; Yahua Zhang; André Schneider; Denis Riendeau; Joseph A Mancini; Linda Davis; Martin Kömhoff; Richard M Breyer; Matthew D Breyer
Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase.
American journal of physiology. Renal physiology 2001;281(6):F1173-7.
2001: Youfei Guan; Yahua Zhang; André Schneider; Linda Davis; Richard M Breyer; Matthew D Breyer
Peroxisome proliferator-activated receptor-gamma activity is associated with renal microvasculature.
American journal of physiology. Renal physiology 2001;281(6):F1036-46.
2001: Richard M Breyer
Prostaglandin EP(1) receptor subtype selectivity takes shape.
Molecular pharmacology 2001;59(6):1357-9.
2001: Richard M Breyer; C K Bagdassarian; Scott A Myers; Matthew D Breyer
Prostanoid receptors: subtypes and signaling.
Annual review of pharmacology and toxicology 2001;41():661-90.
2001: Matthew D Breyer; Richard M Breyer
G protein-coupled prostanoid receptors and the kidney.
Annual review of physiology 2001;63():579-605.
2000: Matthew D Breyer; Richard M Breyer
Prostaglandin E receptors and the kidney.
American journal of physiology. Renal physiology 2000;279(1):F12-23.
2000: James R Sheller; Daphne Mitchell; Barbara Meyrick; J Oates; Richard M Breyer
EP(2) receptor mediates bronchodilation by PGE(2) in mice.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(6):2214-8.
2000: Yahua Zhang; Youfei Guan; André Schneider; Suzanne Brandon; Richard M Breyer; Matthew D Breyer
Characterization of murine vasopressor and vasodepressor prostaglandin E(2) receptors.
Hypertension 2000;35(5):1129-34.
2000: Matthew D Breyer; Richard M Breyer
Prostaglandin receptors: their role in regulating renal function.
Current opinion in nephrology and hypertension 2000;9(1):23-9.
1999: You-Fei Guan; Y H Zhang; Richard M Breyer; Linda Davis; Matthew D Breyer
Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death.
Neoplasia (New York, N.Y.) 1999;1(4):330-9.
1999: Brett A Stillman; Matthew D Breyer; Richard M Breyer
Importance of the extracellular domain for prostaglandin EP(2) receptor function.
Molecular pharmacology 1999;56(3):545-51.
1999: Laurent P Audoly; L Ma; Igor Feoktistov; S K de Foe; Matthew D Breyer; Richard M Breyer
Prostaglandin E-prostanoid-3 receptor activation of cyclic AMP response element-mediated gene transcription.
The Journal of pharmacology and experimental therapeutics 1999;289(1):140-8.
1999: C R Kennedy; Yahua Zhang; Suzanne Brandon; Youfei Guan; Keith Coffee; Colin D Funk; Mark Magnuson; John A Oates; Matthew D Breyer; Richard M Breyer
Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor.
Nature medicine 1999;5(2):217-20.
1998: Brett A Stillman; Laurent P Audoly; Richard M Breyer
A conserved threonine in the second extracellular loop of the human EP2 and EP4 receptors is required for ligand binding.
European journal of pharmacology 1998;357(1):73-82.
1998: Matthew D Breyer; Yahua Zhang; You-Fei Guan; Chuan-Ming Hao; R L Hebert; Richard M Breyer
Regulation of renal function by prostaglandin E receptors.
Kidney international. Supplement 1998;67():S88-94.
1998: Youfei Guan; Yahua Zhang; Richard M Breyer; B Fowler; Linda Davis; R L Hébert; Matthew D Breyer
Prostaglandin E2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor.
The Journal of clinical investigation 1998;102(1):194-201.
1997: Igor Feoktistov; Richard M Breyer; Italo Biaggioni
Prostanoid receptor with a novel pharmacological profile in human erythroleukemia cells.
Biochemical pharmacology 1997;54(8):917-26.
1997: Chuan-Ming Hao; Richard M Breyer; Linda S Davis; Matthew D Breyer
Intrarenal distribution of rabbit PKC zeta.
Kidney international 1997;51(6):1831-7.
1997: Laurent P Audoly; Richard M Breyer
The second extracellular loop of the prostaglandin EP3 receptor is an essential determinant of ligand selectivity.
The Journal of biological chemistry 1997;272(21):13475-8.
1997: Richard M Breyer; Ronald B Emeson; L S Davis; Matthew D Breyer
Structure and localization of the rabbit prostaglandin EP3 receptor.
Advances in experimental medicine and biology 1997;400A():261-8.
1997: Laurent P Audoly; Richard M Breyer
Substitution of charged amino acid residues in transmembrane regions 6 and 7 affect ligand binding and signal transduction of the prostaglandin EP3 receptor.
Molecular pharmacology 1997;51(1):61-8.
1996: Richard M Breyer; L S Davis; C Nian; Reyadh Redha; B Stillman; H R Jacobson; Matthew D Breyer
Cloning and expression of the rabbit prostaglandin EP4 receptor.
The American journal of physiology 1996;270(3 Pt 2):F485-93.
1996: Matthew D Breyer; H R Jacobson; Richard M Breyer
Functional and molecular aspects of renal prostaglandin receptors.
Journal of the American Society of Nephrology : JASN 1996;7(1):8-17.
1995: Richard L Hébert; Richard M Breyer; H R Jacobson; Matthew D Breyer
Functional and molecular aspects of prostaglandin E receptors in the cortical collecting duct.
Canadian journal of physiology and pharmacology 1995;73(2):172-9.
1994: Richard M Breyer; Ronald B Emeson; J L Tarng; Matthew D Breyer; L S Davis; R M Abromson; S M Ferrenbach
Alternative splicing generates multiple isoforms of a rabbit prostaglandin E2 receptor.
The Journal of biological chemistry 1994;269(8):6163-9.
1993: Matthew D Breyer; H R Jacobson; L S Davis; Richard M Breyer
In situ hybridization and localization of mRNA for the rabbit prostaglandin EP3 receptor.
Kidney international 1993;44(6):1372-8.