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Wen Xue

Research Profile

Living Beings

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RNA Interference

Genes & Molecular Sequences

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Genomics

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Oligonucleotide Array Sequence Analysis

Anatomy

Physiology

Chemicals & Drugs

Tumor Suppressor Protein p53

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Haploinsufficiency

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Publications

TOP 3
Wen Xue; Lars Zender; Jack Zhang; Johannes Zuber; James Hicks; Thomas Kitzing; Alexander Krasnitz; Weijun Luo; Scott Powers; Amy R Rappaport; Kate Revill; Stephanie Roessler; Nikolaus Schultz; Janelle Simon; Xin Wei Wang; Susann Weissmueller; Michael Wigler; Scott W Lowe
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.
Lars Zender; Wen Xue; Johannes Zuber; Camile P Semighini; Alexander Krasnitz; Beicong Ma; Peggy Zender; Stefan Kubicka; John Luk; Peter Schirmacher; W Richard McCombie; Michael Wigler; James Hicks; Gregory J Hannon; Scott Powers; Scott W Lowe
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.
Darren J Burgess; Jason Doles; Lars Zender; Wen Xue; Beicong Ma; W Richard McCombie; Gregory J Hannon; Scott W Lowe; Michael T Hemann
Topoisomerase levels determine chemotherapy response in vitro and in vivo.

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All Publications

2012: Wen Xue; Lars Zender; Jack Zhang; Johannes Zuber; James Hicks; Thomas Kitzing; Alexander Krasnitz; Weijun Luo; Scott Powers; Amy R Rappaport; Kate Revill; Stephanie Roessler; Nikolaus Schultz; Janelle Simon; Xin Wei Wang; Susann Weissmueller; Michael Wigler; Scott W Lowe
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(21):8212-7.
2008: Lars Zender; Wen Xue; Johannes Zuber; Camile P Semighini; Alexander Krasnitz; Beicong Ma; Peggy Zender; Stefan Kubicka; John Luk; Peter Schirmacher; W Richard McCombie; Michael Wigler; James Hicks; Gregory J Hannon; Scott Powers; Scott W Lowe
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.
Cell 2008;135(5):852-64.
2008: Darren J Burgess; Jason Doles; Lars Zender; Wen Xue; Beicong Ma; W Richard McCombie; Gregory J Hannon; Scott W Lowe; Michael T Hemann
Topoisomerase levels determine chemotherapy response in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9053-8.
2008: Wen Xue; Alexander Krasnitz; Robert Lucito; Raffaella Sordella; Linda Vanaelst; Carlos Cordon-Cardo; Stephan Singer; Florian Kuehnel; Michael Wigler; Scott Powers; Lars Zender; Scott W Lowe
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.
Genes & development 2008;22(11):1439-44.
2008: Valery Krizhanovsky; Wen Xue; Lars Zender; M Yon; Eva Hernando; Scott W Lowe
Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology.
Cold Spring Harbor symposia on quantitative biology 2008;73():513-22.
2007: Lin He; Xingyue He; Lee P Lim; Elisa de Stanchina; Zhenyu Xuan; Yu Liang; Wen Xue; Lars Zender; Jill Magnus; Dana Ridzon; Aimee L Jackson; Peter Linsley; Caifu Chen; Scott W Lowe; Michele A Cleary; Gregory J Hannon
A microRNA component of the p53 tumour suppressor network.
Nature 2007;447(7148):1130-4.
2007: Wen Xue; Lars Zender; Cornelius Miething; Ross A Dickins; Eva Hernando; Valery Krizhanovsky; Carlos Cordon-Cardo; Scott W Lowe
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas.
Nature 2007;445(7128):656-60.
2006: B Lakshmi; Ira M Hall; Christopher Egan; Joan Alexander; Anthony Leotta; John Healy; Lars Zender; Mona S Spector; Wen Xue; Scott W Lowe; Michael Wigler; Robert Lucito
Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11234-9.
2006: Lars Zender; Mona S Spector; Wen Xue; Peer Flemming; Carlos Cordon-Cardo; John Silke; Sheung-Tat Fan; John Luk; Michael Wigler; Gregory J Hannon; David Mu; Robert Lucito; Scott Powers; Scott W Lowe
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.
Cell 2006;125(7):1253-67.
2005: Lars Zender; Wen Xue; Carlos Cordón-Cardo; Gregory J Hannon; Robert Lucito; Scott Powers; P Flemming; Mona S Spector; Scott W Lowe
Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors.
Cold Spring Harbor symposia on quantitative biology 2005;70():251-61.