FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Adly Yacoub

Research Profile

Anatomy

Chemicals & Drugs

Physiology

Living Beings

Disorders

Glioblastoma

Genes & Molecular Sequences

Genes, Tumor Suppressor

Co-author Network

Publications

TOP 3
Yong Tang; Gary Tye; Adly Yacoub; Steven Grant; Hossein A Hamed; Andrew Poklepovic; Paul Dent
Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells.
Laurence Booth; Sophie C Cazanave; Ching-Shih Chen; Steven Grant; Hossein A Hamed; Besim Ogretmen; Adly Yacoub; Paul Dent
OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing.
Maciej Kmieciak; Debasmita Basu; Harry D Bear; Kyle K Payne; Lisa Smith; Amir Toor; Xiang-Yang Wang; Adly Yacoub; Masoud H Manjili
Activated NKT cells and NK cells render T cells resistant to myeloid-derived suppressor cells and result in an effective adoptive cellular therapy against breast cancer in the FVBN202 transgenic mouse.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Adly Yacoub (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Yong Tang; Gary Tye; Adly Yacoub; Steven Grant; Hossein A Hamed; Andrew Poklepovic; Paul Dent
Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells.
Cancer biology & therapy 2012;13(7):567-74.
2012: Laurence Booth; Sophie C Cazanave; Ching-Shih Chen; Steven Grant; Hossein A Hamed; Besim Ogretmen; Adly Yacoub; Paul Dent
OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing.
Cancer biology & therapy 2012;13(4):224-36.
2011: Maciej Kmieciak; Debasmita Basu; Harry D Bear; Kyle K Payne; Lisa Smith; Amir Toor; Xiang-Yang Wang; Adly Yacoub; Masoud H Manjili
Activated NKT cells and NK cells render T cells resistant to myeloid-derived suppressor cells and result in an effective adoptive cellular therapy against breast cancer in the FVBN202 transgenic mouse.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(2):708-17.
2011: M Danielle Bareford; Matthew E Burow; Nichola Cruickshanks; Patrick Eulitt; Paul B Fisher; Steven Grant; Hossein A Hamed; Nisan Hubbard; Richard G Moran; Kenneth P Nephew; Margaret A Park; Yong Tang; Gary Tye; Adly Yacoub; Paul Dent
Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells.
Cancer research 2011;71(14):4955-67.
2011: Paul Dent; Yong Tang; Adly Yacoub; Yun Dai; Paul B Fisher; Steven Grant
CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle.
Molecular interventions 2011;11(2):133-40.
2011: Margaret A Park; Hossein A Hamed; Clint Mitchell; Nichola Cruickshanks; Rupesh Dash; Jeremy C Allegood; Igor P Dmitriev; Gary Tye; Besim Ogretmen; Sarah Spiegel; Adly Yacoub; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.
Molecular pharmacology 2011;79(3):368-80.
2010: Patrick J Eulitt; Margaret A Park; Hamed Hossein; Nichola Cruikshanks; Chen Yang; Igor P Dmitriev; Adly Yacoub; David T Curiel; Paul B Fisher; Paul Dent
Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery.
Cancer biology & therapy 2010;10(12):1290-305.
2010: Wentao Jia; Roger M Loria; Margaret A Park; Adly Yacoub; Paul Dent; Martin R Graf
The neuro-steroid, 5-androstene 3β,17α diol; induces endoplasmic reticulum stress and autophagy through PERK/eIF2α signaling in malignant glioma cells and transformed fibroblasts.
The international journal of biochemistry & cell biology 2010;42(12):2019-29.
2010: Clint Mitchell; Adly Yacoub; Hamed Hossein; Aditi Pandya Martin; M Danielle Bareford; Patrick Eulitt; Chen Yang; Kenneth P Nephew; Paul Dent
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
Cancer biology & therapy 2010;10(9):903-17.
2010: Paul Dent; Adly Yacoub; Hossein A Hamed; Margaret A Park; Rupesh Dash; Sujit K Bhutia; Devanand Sarkar; Xiang-Yang Wang; Pankaj Gupta; Luni Emdad; Irina V Lebedeva; Moira Sauane; Zao-Zhong Su; Mohamed Rahmani; William C Broaddus; Harold F Young; Maciej S Lesniak; Steven Grant; David T Curiel; Paul B Fisher
The development of MDA-7/IL-24 as a cancer therapeutic.
Pharmacology & therapeutics 2010;128(2):375-84.
2010: Clint Mitchell; Margaret Park; Patrick Eulitt; Chen Yang; Adly Yacoub; Paul Dent
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.
Molecular pharmacology 2010;78(5):909-17.
2010: Rupesh Dash; Sujit K Bhutia; Belal Azab; Zao-Zhong Su; Bridget A Quinn; Timothy P Kegelmen; Swadesh K Das; Keetae Kim; Seok-Geun Lee; Margaret A Park; Adly Yacoub; Mohammed Rahmani; Luni Emdad; Igor P Dmitriev; Xiang-Yang Wang; Devanand Sarkar; Steven Grant; Paul Dent; David T Curiel; Paul B Fisher
mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.
Cytokine & growth factor reviews 2010;21(5):381-91.
2010: Paul Dent; Adly Yacoub; Hossein A Hamed; Margaret A Park; Rupesh Dash; Sujit K Bhutia; Devanand Sarkar; Pankaj Gupta; Luni Emdad; Irina V Lebedeva; Moira Sauane; Zao-Zhong Su; Mohamed Rahmani; William C Broaddus; Harold F Young; Maciej Lesniak; Steven Grant; David T Curiel; Paul B Fisher
MDA-7/IL-24 as a cancer therapeutic: from bench to bedside.
Anti-cancer drugs 2010;21(8):725-31.
2010: Margaret A Park; Roland Reinehr; Dieter Häussinger; Christina Voelkel Johnson; Besim Ogretmen; Adly Yacoub; Steven Grant; Paul Dent
Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells.
Molecular cancer therapeutics 2010;9(8):2220-31.
2010: Margaret A Park; Clint Mitchell; Guo Zhang; Adly Yacoub; Jeremy Allegood; Dieter Häussinger; Roland Reinehr; Andrew Larner; Sarah Spiegel; Paul B Fisher; Christina Voelkel-Johnson; Besim Ogretmen; Steven Grant; Paul Dent
Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.
Cancer research 2010;70(15):6313-24.
2010: R Dash; I Dmitriev; Zao-Zhong Su; S K Bhutia; B Azab; N Vozhilla; Adly Yacoub; Paul Dent; David T Curiel; Devanand Sarkar; Paul B Fisher
Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells.
Cancer gene therapy 2010;17(7):447-56.
2010: Rupesh Dash; Joanna E Richards; Zhao-Zhong Su; Sujit K Bhutia; Belal Azab; Mohamed Rahmani; Girija Dasmahapatra; Adly Yacoub; Paul Dent; Igor P Dmitriev; David T Curiel; Steven Grant; Maurizio Pellecchia; John C Reed; Devanand Sarkar; Paul B Fisher
Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine.
Cancer research 2010;70(12):5034-45.
2010: Hossein A Hamed; Adly Yacoub; Margaret A Park; Patrick J Eulitt; Rupesh Dash; Devanand Sarkar; Igor P Dmitriev; Maciej S Lesniak; Khalid Shah; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(6):1130-42.
2010: Teneille Walker; Clint Mitchell; Margaret A Park; Adly Yacoub; Mohamed Rahmani; Dieter Häussinger; Roland Reinehr; Christina Voelkel Johnson; Paul B Fisher; Steven Grant; Paul Dent
17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species.
Molecular cancer therapeutics 2010;9(5):1378-95.
2010: Sujit K Bhutia; Rupesh Dash; Swadesh K Das; Belal Azab; Zao-Zhong Su; Seok-Geun Lee; Steven Grant; Adly Yacoub; Paul Dent; David T Curiel; Devanand Sarkar; Paul B Fisher
Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24.
Cancer research 2010;70(9):3667-76.
2010: Hossein A Hamed; Adly Yacoub; Margaret A Park; Patrick Eulitt; Devanand Sarkar; Igor P Dimitrie; Ching-Shih Chen; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins.
Cancer biology & therapy 2010;9(7):526-36.
2010: Adly Yacoub; Hossein A Hamed; Jeremy C Allegood; Clint Mitchell; Sarah Spiegel; Maciej S Lesniak; Besim Ogretmen; Rupesh Dash; Devanand Sarkar; William C Broaddus; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
Cancer research 2010;70(3):1120-9.
2010: Adly Yacoub; Renyan Liu; Margaret A Park; Hossein A Hamed; Rupesh Dash; Danielle N Schramm; Devanand Sarkar; Igor P Dimitriev; Jessica K Bell; Steven Grant; Nicholas P Farrell; David T Curiel; Paul B Fisher; Paul Dent
Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells.
Molecular pharmacology 2010;77(2):298-310.
2010: Luni Emdad; Devanand Sarkar; Seok-Geun Lee; Zao-Zhong Su; Byoung Kwon Yoo; Rupesh Dash; Adly Yacoub; Christine E Fuller; Khalid Shah; Paul Dent; Jeffrey N Bruce; Paul B Fisher
Astrocyte elevated gene-1: a novel target for human glioma therapy.
Molecular cancer therapeutics 2010;9(1):79-88.
2009: Teneille Walker; Clint Mitchell; Margaret A Park; Adly Yacoub; Martin Graf; Mohamed Rahmani; Peter J Houghton; Christina Voelkel Johnson; Steven Grant; Paul Dent
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
Molecular pharmacology 2009;76(2):342-55.
2009: Margaret A Park; Teneille Walker; Aditi Pandya Martin; Jeremy C Allegood; Nicollaq Vozhilla; Luni Emdad; Devanand Sarkar; Mohamed Rahmani; Martin Graf; Adly Yacoub; Constantinos Koumenis; Sarah Spiegel; David T Curiel; Christina Voelkel Johnson; Steven Grant; Paul B Fisher; Paul Dent
MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.
Molecular cancer therapeutics 2009;8(5):1280-91.
2009: Xueping Zhang; Marcia V Fournier; Joy L Ware; Mina J Bissell; Adly Yacoub; Zendra E Zehner
Inhibition of vimentin or beta1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo.
Molecular cancer therapeutics 2009;8(3):499-508.
2009: Nathan T Ihle; Robert Lemos; Peter Wipf; Adly Yacoub; Clint Mitchell; Doris R Siwak; Gordon B Mills; Paul Dent; D Lynn Kirkpatrick; Garth Powis
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
Cancer research 2009;69(1):143-50.
2008: Jyotsana Singhal; shashank singhal; Sushma Yadav; Sumihiro Suzuki; Molly M Warnke; Adly Yacoub; Paul Dent; Sejong Bae; Rajendra Sharma; Yogesh C Awasthi; Daniel W Armstrong; Sanjay Awasthi
RLIP76 in defense of radiation poisoning.
International journal of radiation oncology, biology, physics 2008;72(2):553-61.
2008: Margaret A Park; Guo Zhang; Clint Mitchell; Mohamed Rahmani; Hossein Hamed; Michael P Hagan; Adly Yacoub; David T Curiel; Paul B Fisher; Steven Grant; Paul Dent
Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
Molecular cancer therapeutics 2008;7(9):2633-48.
2008: Guo Zhang; Margaret A Park; Clint Mitchell; Hossein Hamed; Mohamed Rahmani; Aditi Pandya Martin; David T Curiel; Adly Yacoub; Martin Graf; Ray Lee; John D Roberts; Paul B Fisher; Steven Grant; Paul Dent
Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(17):5385-99.
2008: Paul Dent; Adly Yacoub; Margaret Park; Devanand Sarkar; Khalid Shah; David T Curiel; Steven Grant; Paul B Fisher
Searching for a cure: gene therapy for glioblastoma.
Cancer biology & therapy 2008;7(9):1335-40.
2008: Aditi Pandya Martin; Anna Miller; Luni Emad; Mohamed Rahmani; Teneille Walker; Clint Mitchell; Michael P Hagan; Margaret A Park; Adly Yacoub; Paul B Fisher; Steven Grant; Paul Dent
Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation.
Molecular pharmacology 2008;74(3):807-22.
2008: Adly Yacoub; Hossein Hamed; Luni Emdad; Wagner Dos Santos; Pankaj Gupta; William C Broaddus; Viswanathan Ramakrishnan; Devanand Sarkar; Khalid Shah; David T Curiel; Steven Grant; Paul B Fisher; Paul Dent
MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors.
Cancer biology & therapy 2008;7(6):917-33.
2008: Margaret A Park; Adly Yacoub; Devanand Sarkar; Luni Emdad; Mohamed Rahmani; Sarah Spiegel; Constantinos Koumenis; Martin Graf; David T Curiel; Steven Grant; Paul B Fisher; Paul Dent
PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells.
Autophagy 2008;4(4):513-5.
2008: Hossein Hamed; Clint Mitchell; Margaret A Park; David Hanna; Aditi Pandya Martin; Benjamin Harrison; William Hawkins; David A Curiel; Paul B Fisher; Steven Grant; Adly Yacoub; Michael P Hagan; Paul Dent
Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo.
Cancer biology & therapy 2008;7(4):587-93.
2008: Margaret A Park; Adly Yacoub; Mohamed Rahmani; Guo Zhang; Lori Hart; Michael P Hagan; Stuart K Calderwood; Michael Y Sherman; Constantinos Koumenis; Sarah Spiegel; Ching-Shih Chen; Martin Graf; David T Curiel; Paul B Fisher; Steven Grant; Paul Dent
OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells.
Molecular pharmacology 2008;73(4):1168-84.
2008: Hossein Hamed; William Hawkins; Clint Mitchell; Donna Gilfor; Guo Zhang; Xin-Yan Pei; Yun Dai; Michael P Hagan; John D Roberts; Adly Yacoub; Steven Grant; Paul Dent
Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo.
Molecular cancer therapeutics 2008;7(3):616-29.
2008: Adly Yacoub; Pankaj Gupta; Margaret A Park; Mohammed Rhamani; Hossein Hamed; David Hanna; Guo Zhang; Devanand Sarkar; Irina Lebedeva; Luni Emdad; Constantinos Koumenis; David T Curiel; Steven Grant; Paul B Fisher; Paul Dent
Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling.
Molecular cancer therapeutics 2008;7(2):314-29.
2008: Adly Yacoub; Margaret A Park; Pankaj Gupta; Mohamed Rahmani; Guo Zhang; Hossein Hamed; David Hanna; Devanand Sarkar; Irina Lebedeva; Luni Emdad; Moira Sauane; Nicollaq Vozhilla; Sarah Spiegel; Constantinos Koumenis; Martin Graf; David T Curiel; Steven Grant; Paul B Fisher; Paul Dent
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.
Molecular cancer therapeutics 2008;7(2):297-313.
2007: Clint Mitchell; Margaret A Park; Guo Zhang; Adly Yacoub; David T Curiel; Paul B Fisher; John D Roberts; Steven Grant; Paul Dent
Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.
Molecular cancer therapeutics 2007;6(12 Pt 1):3101-12.
2007: Clint Mitchell; Peyman Kabolizadeh; John Ryan; John D Roberts; Adly Yacoub; David T Curiel; Paul B Fisher; Michael P Hagan; Nicholas Farrell; Steven Grant; Paul Dent
Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling.
Molecular pharmacology 2007;72(3):704-14.
2007: Michael P Hagan; Adly Yacoub; Paul Dent
Radiation-induced PARP activation is enhanced through EGFR-ERK signaling.
Journal of cellular biochemistry 2007;101(6):1384-93.
2007: Kristoffer Valerie; Adly Yacoub; Michael P Hagan; David T Curiel; Paul B Fisher; Steven Grant; Paul Dent
Radiation-induced cell signaling: inside-out and outside-in.
Molecular cancer therapeutics 2007;6(3):789-801.
2007: Clint Mitchell; Margaret A Park; Guo Zhang; Song Iy Han; Hisashi Harada; Richard A Franklin; Adly Yacoub; Pin-Lan Li; Phillip B Hylemon; Steven Grant; Paul Dent
17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines.
Molecular cancer therapeutics 2007;6(2):618-32.
2007: Adly Yacoub; William Hawkins; David Hanna; Hong Young; Margaret A Park; Mark Grant; John D Roberts; David T Curiel; Paul B Fisher; Kristoffer Valerie; Steven Grant; Michael P Hagan; Paul Dent
Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment.
Molecular pharmacology 2007;71(1):259-75.
2006: Adly Yacoub; Anna Miller; Ruben Caron; Liang Qiao; David A Curiel; Paul B Fisher; Michael P Hagan; Steven Grant; Paul Dent
Radiotherapy-induced signal transduction.
Endocrine-related cancer 2006;13 Suppl 1():S99-114.
2006: Adly Yacoub; Donna Gilfor; William Hawkins; Margaret A Park; David Hanna; Michael P Hagan; David T Curiel; Paul B Fisher; Steven Grant; Paul Dent
MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo.
Cancer biology & therapy 2006;5(10):1332-9.
2006: Adly Yacoub; Margaret A Park; David Hanna; Young Hong; Clint Mitchell; Aditi P Pandya; Hisashi Harada; Garth Powis; Ching-Shih Chen; Constantinos Koumenis; Steven Grant; Paul Dent
OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells.
Molecular pharmacology 2006;70(2):589-603.
2005: Paul Dent; Song Iy Han; Clint Mitchell; Elaine Studer; Adly Yacoub; Jennifer Rubin Grandis; Steven Grant; Geoffrey W Krystal; Phillip B Hylemon
Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.
Biochemical pharmacology 2005;70(11):1685-96.
2005: William Hawkins; Clint Mitchell; Robert McKinstry; Donna Gilfor; James Starkey; Yun Dai; Kathy Dawson; Viswanathan Ramakrishnan; John D Roberts; Adly Yacoub; Steven Grant; Paul Dent
Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth.
Cancer biology & therapy 2005;4(11):1275-84.
2005: Sanjay Awasthi; shashank singhal; Sushma Yadav; Jyotsana Singhal; Kenneth Drake; Aalok Nadkar; Ewa Zajac; Dilki Wickramarachchi; Nancy Rowe; Adly Yacoub; Paul Boor; Seema Dwivedi; Paul Dent; Wendy E Jarman; Berchmans John; Yogesh C Awasthi
RLIP76 is a major determinant of radiation sensitivity.
Cancer research 2005;65(14):6022-8.
2005: Paul Dent; Adly Yacoub; Steven Grant; David T Curiel; Paul B Fisher
MDA-7/IL-24 regulates proliferation, invasion and tumor cell radiosensitivity: a new cancer therapy?
Journal of cellular biochemistry 2005;95(4):712-9.
2005: Paul Dent; Adly Yacoub; Steven Grant
DMC: novel celecoxib derivatives to rap cancer.
Cancer biology & therapy 2005;4(5):583-4.
2005: Zao-Zhong Su; Luni Emdad; Devanand Sarkar; Aaron Randolph; Kristoffer Valerie; Adly Yacoub; Paul Dent; Paul B Fisher
Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3).
Oncogene 2005;24(13):2247-55.
2005: Rubén W Carón; Adly Yacoub; Clint Mitchell; Xiaoyu Zhu; Young Hong; Takehiko Sasazuki; Senji Shirasawa; Michael P Hagan; Steven Grant; Paul Dent
Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.
Cell cycle (Georgetown, Tex.) 2005;4(3):456-64.
2005: Rubén W Carón; Adly Yacoub; Min Li; Xiaoyu Zhu; Clint Mitchell; Young Hong; William Hawkins; Takehiko Sasazuki; Senji Shirasawa; Alan P Kozikowski; Philip A Dennis; Michael P Hagan; Steven Grant; Paul Dent
Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.
Molecular cancer therapeutics 2005;4(2):257-70.
2005: Rubén W Carón; Adly Yacoub; Xiaoyu Zhu; Clint Mitchell; Song Iy Han; Takehiko Sasazuki; Senji Shirasawa; Michael P Hagan; Steven Grant; Paul Dent
H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.
Molecular cancer therapeutics 2005;4(2):243-55.
2005: Irina Lebedeva; Zao-Zhong Su; Devanand Sarkar; Rahul V Gopalkrishnan; Samuel Waxman; Adly Yacoub; Paul Dent; Paul B Fisher
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Oncogene 2005;24(4):585-96.
2005: Irina Lebedeva; Moira Sauane; Rahul V Gopalkrishnan; Devanand Sarkar; Zao-Zhong Su; Pankaj Gupta; John Nemunaitis; Casey Cunningham; Adly Yacoub; Paul Dent; Paul B Fisher
mda-7/IL-24: exploiting cancer's Achilles' heel.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(1):4-18.
2004: Moira Sauane; Rahul V Gopalkrishnan; Heng-Tong Choo; Pankaj Gupta; Irina Lebedeva; Adly Yacoub; Paul Dent; Paul B Fisher
Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein.
Oncogene 2004;23(46):7679-90.
2004: Michael P Hagan; Adly Yacoub; Paul Dent
Ionizing radiation causes a dose-dependent release of transforming growth factor alpha in vitro from irradiated xenografts and during palliative treatment of hormone-refractory prostate carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(17):5724-31.
2004: Adly Yacoub; Clint Mitchell; Young Hong; Rahul V Gopalkrishnan; Zao-Zhong Su; Pankaj Gupta; Moria Sauane; Irina Lebedeva; David T Curiel; Parameshwar J Mahasreshti; Myrna R Rosenfeld; William C Broaddus; C David James; Steven Grant; Paul B Fisher; Paul Dent
MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells.
Cancer biology & therapy 2004;3(8):739-51.
2003: Adly Yacoub; Song Iy Han; Ruben Caron; Donna Gilfor; Susan Mooberry; Steven Grant; Paul Dent
Sequence dependent exposure of mammary carcinoma cells to Taxotere and the MEK1/2 inhibitor U0126 causes enhanced cell killing in vitro.
Cancer biology & therapy 2003;2(6):670-6.
2003: Paul Dent; Adly Yacoub; Paul B Fisher; Michael P Hagan; Steven Grant
MAPK pathways in radiation responses.
Oncogene 2003;22(37):5885-96.
2003: Adly Yacoub; Clint Mitchell; Andrea Lister; Irina Lebedeva; Devanand Sarkar; Zao-Zhong Su; Carter Sigmon; Robert McKinstry; Viswanathan Ramakrishnan; Liang Qiao; William C Broaddus; Rahul V Gopalkrishnan; Steven Grant; Paul B Fisher; Paul Dent
Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(9):3272-81.
2003: Adly Yacoub; Clint Mitchell; Irina Lebedeva; Devanand Sarkar; Zao-Zhong Su; Robert McKinstry; Rahul V Gopalkrishnan; Steven Grant; Paul B Fisher; Paul Dent
mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling.
Cancer biology & therapy 2003;2(4):347-53.
2003: Adly Yacoub; Clint Mitchell; Jessica Brannon; Elizabeth Rosenberg; Liang Qiao; Robert McKinstry; W Marston Linehan; Zao-shong Su; Devanand Sarkar; Irina Lebedeva; Kristoffer Valerie; Rahul V Gopalkrishnan; Steven Grant; Paul B Fisher; Paul Dent
MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.
Molecular cancer therapeutics 2003;2(7):623-32.
2003: Adly Yacoub; Robert McKinstry; Darin Hinman; Theodore Chung; Paul Dent; Michael P Hagan
Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling.
Radiation research 2003;159(4):439-52.
2003: Paul Dent; Adly Yacoub; Joseph N Contessa; Ruben Caron; George P Amorino; Kristoffer Valerie; Michael P Hagan; Steven Grant; Rupert K Schmidt-Ullrich
Stress and radiation-induced activation of multiple intracellular signaling pathways.
Radiation research 2003;159(3):283-300.
2003: Zao-Zhong Su; Irina Lebedeva; Devanand Sarkar; Rahul V Gopalkrishnan; Moira Sauane; Carter Sigmon; Adly Yacoub; Kristoffer Valerie; Paul Dent; Paul B Fisher
Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.
Oncogene 2003;22(8):1164-80.
2002: Robert McKinstry; Liang Qiao; Adly Yacoub; Yun Dai; Roy H Decker; Shawn Holt; Michael P Hagan; Steven Grant; Paul Dent
Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.
Cancer biology & therapy 2002;1(3):243-53.
2002: Liang Qiao; Adly Yacoub; Elaine Studer; Seema Gupta; Xin-Yan Pei; Steven Grant; Phillip B Hylemon; Paul Dent
Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes.
Hepatology (Baltimore, Md.) 2002;35(4):779-89.
2002: Liang Qiao; Adly Yacoub; Robert McKinstry; Jong Sung Park; Ruben Caron; Paul B Fisher; Michael P Hagan; Steven Grant; Paul Dent
Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms.
Cancer biology & therapy 2002;1(2):168-76.
2002: Stanislav Y Shvartsman; M P Hagan; Adly Yacoub; P Dent; H Steven Wiley; Douglas A Lauffenburger
Autocrine loops with positive feedback enable context-dependent cell signaling.
American journal of physiology. Cell physiology 2002;282(3):C545-59.
2001: Liang Qiao; K Leach; Robert McKinstry; Donna Gilfor; Adly Yacoub; Jong Sung Park; Steven Grant; Phillip B Hylemon; Paul B Fisher; Paul Dent
Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression.
Hepatology (Baltimore, Md.) 2001;34(5):906-17.
2001: Adly Yacoub; J S Park; L Qiao; Paul Dent; Michael P Hagan
MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion.
International journal of radiation biology 2001;77(10):1067-78.
2001: Jong Sung Park; Liang Qiao; Zao-Zhong Su; Darin Hinman; Karen A Willoughby; Robert McKinstry; Adly Yacoub; Gregory J Duigou; C S H Young; Steven Grant; Michael P Hagan; E Ellis; Paul B Fisher; Paul Dent
Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways.
Oncogene 2001;20(25):3266-80.