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Michael Yaffe

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Signal Transduction

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Jeremy M Rock; Stephen John Smerdon; Lasse Stach; Mark Winey; Catherine C L Wong; Michael B Yaffe; John R Yates; Michele H Jones; Jamie M Keck; Daniel Lim; Roksana W Ogrodowicz; Angelika Amon
Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.
David M Weingeist; David K Wood; Michael B Yaffe; Scott Floyd; Jing Ge; Qiuying Huang; James T Mutamba; Elizabeth A Rowland; Bevin P Engelward
Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.
Katja Höpker; Safiya Khurshid; Tülay Kisner; Peter Kurschat; Tobias Lamkemeyer; Max C Liebau; Drew Lowery; René H Medema; Roman Ulrich Müller; H Christian Reinhardt; Ulrike Resch; Frederik Roels; Fabian Röther; Bernhard Schermer; Katharina Schilberg; Björn Schumacher; Tamina Seeger-Nukpezah; Martin L Sos; Roman K Thomas; Michael B Yaffe; Shuhua Chen; Francesca Fabretti; Matthias Fischer; Matthias Gaestel; Henning Hagmann; Pia Hasskamp; Lukas Heukamp; Malte P Bartram; Thomas Benzing
AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.

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All Publications

2013: Jeremy M Rock; Stephen John Smerdon; Lasse Stach; Mark Winey; Catherine C L Wong; Michael B Yaffe; John R Yates; Michele H Jones; Jamie M Keck; Daniel Lim; Roksana W Ogrodowicz; Angelika Amon
Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.
Science (New York, N.Y.) 2013;340(6134):871-5.
2013: David M Weingeist; David K Wood; Michael B Yaffe; Scott Floyd; Jing Ge; Qiuying Huang; James T Mutamba; Elizabeth A Rowland; Bevin P Engelward
Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.
Cell cycle (Georgetown, Tex.) 2013;12(6):907-15.
2012: Katja Höpker; Safiya Khurshid; Tülay Kisner; Peter Kurschat; Tobias Lamkemeyer; Max C Liebau; Drew Lowery; René H Medema; Roman Ulrich Müller; H Christian Reinhardt; Ulrike Resch; Frederik Roels; Fabian Röther; Bernhard Schermer; Katharina Schilberg; Björn Schumacher; Tamina Seeger-Nukpezah; Martin L Sos; Roman K Thomas; Michael B Yaffe; Shuhua Chen; Francesca Fabretti; Matthias Fischer; Matthias Gaestel; Henning Hagmann; Pia Hasskamp; Lukas Heukamp; Malte P Bartram; Thomas Benzing
AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.
The EMBO journal 2012;31(20):3961-75.
2012: Ericka M Noonan; Dharini Shah; Michael B Yaffe; Douglas A Lauffenburger; Leona D Samson
O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.
Integrative biology : quantitative biosciences from nano to macro 2012;4(10):1237-55.
2012: Namit Singh; James R Thompson; Timothy D Wiltshire; Michael B Yaffe; Harihar Basnet; Maria-Victoria Botuyan; Fergus J Couch; Annie Héroux; Duaa H Mohammad; Michael G Rosenfeld; Georges Mer
Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14381-6.
2012: Michael J Lee; Gavin MacBeath; Peter K Sorger; Alexandra K. Gardino; Anne Margriet Heijink; Albert S Ye; Michael B Yaffe
Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks.
Cell 2012;149(4):780-94.
2012: Duaa H Mohammad; Michael B Yaffe
Fixin' to divide.
Molecular cell 2012;45(3):273-5.
2012: Wendy Niedelman; Emily E Rosowski; Eric Spooner; Joris K Sprokholt; Michael B Yaffe; Ailan Farid Arenas; Daniel A Gold; Daniel Lim; Mariane B Melo; jeroen saeij
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.
PLoS pathogens 2012;8(6):e1002784.
2012: Andrea R Tentner; Douglas A Lauffenburger; Michael J Lee; Gerard J. Ostheimer; Leona D Samson; Michael B Yaffe
Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress.
Molecular systems biology 2012;8():568.
2011: Karin Grosstessner-Hain; Björn Hegemann; Otto Hudecz; Brian A Joughin; Norbert Kraut; Maria Novatchkova; Jan-Michael Peters; Peter Pichler; Jonathan Rameseder; Elisabeth Roitinger; Michael B Yaffe; Karl Mechtler
Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome.
Molecular & cellular proteomics : MCP 2011;10(11):M111.008540.
2011: Kristen M Naegle; Roy E Welsch; Forest M White; Michael B Yaffe; Douglas A Lauffenburger
MCAM: multiple clustering analysis methodology for deriving hypotheses and insights from high-throughput proteomic datasets.
PLoS computational biology 2011;7(7):e1002119.
2011: Björn Hegemann; Jean-Karim Hériché; Otto Hudecz; James Hutchins; Anthony A Hyman; Norbert Kraut; Péter Lénárt; Sihan Liu; Michael Mazanek; Karl Mechtler; Maria Novatchkova; Ina Poser; Jonathan Rameseder; Martina M Sykora; Michael B Yaffe; Jan-Michael Peters
Systematic phosphorylation analysis of human mitotic protein complexes.
Science signaling 2011;4(198):rs12.
2011: Jes Alexander; Tobias Ehrenberger; Andrew M Fry; Björn Hegemann; Otto Hudecz; James Hutchins; Frank Ivins; Brian A Joughin; Daniel Lim; Karl Mechtler; Andrea Musacchio; Erich A Nigg; Jan-Michael Peters; Fabio Sessa; Stephen John Smerdon; P Todd Stukenberg; Michael B Yaffe
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.
Science signaling 2011;4(179):ra42.
2010: Simon Pennell; Sarah Westcott; Miguel Ortiz-Lombardía; Dony Patel; Jiejin Li; Timothy J Nott; Duaa Mohammed; Roger S Buxton; Michael B Yaffe; chandra verma; Stephen John Smerdon
Structural and functional analysis of phosphothreonine-dependent FHA domain interactions.
Structure (London, England : 1993) 2010;18(12):1587-95.
2010: H Christian Reinhardt; Pia Hasskamp; Ingolf Schmedding; Sandra Morandell; Marcel A T M van Vugt; Xiaozhe Wang; Rune Linding; Shao-En Ong; David Weaver; Steven A Carr; Michael B Yaffe
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.
Molecular cell 2010;40(1):34-49.
2010: Matthew J Lazzara; Keara Lane; Richard Chan; Paul J Jasper; Michael B Yaffe; Peter K Sorger; Tyler Jacks; Benjamin G Neel; Douglas A Lauffenburger
Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations.
Cancer research 2010;70(9):3843-50.
2010: Jian Wen; Erik W Wilker; Michael B Yaffe; Klavs F Jensen
Microfluidic preparative free-flow isoelectric focusing: system optimization for protein complex separation.
Analytical chemistry 2010;82(4):1253-60.
2010: Marcel A T M van Vugt; Alexandra K Gardino; Rune Linding; Gerard J. Ostheimer; H Christian Reinhardt; Shao-En Ong; Chris S Tan; Hua Miao; Susan M Keezer; Jeijin Li; Tony Pawson; Timothy A Lewis; Steven A Carr; Stephen John Smerdon; Thijn R Brummelkamp; Michael B Yaffe
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
PLoS biology 2010;8(1):e1000287.
2009: H Christian Reinhardt; Hai Jiang; Michael T Hemann; Michael B Yaffe
Exploiting synthetic lethal interactions for targeted cancer therapy.
Cell cycle (Georgetown, Tex.) 2009;8(19):3112-9.
2009: Duaa Mohammad; Michael B Yaffe
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response.
DNA repair 2009;8(9):1009-17.
2009: Hai Jiang; H Christian Reinhardt; Jirina Bartkova; Johanna Tommiska; Carl Blomqvist; Heli Nevanlinna; Jiri Bartek; Michael B Yaffe; Michael T Hemann
The combined status of ATM and p53 link tumor development with therapeutic response.
Genes & development 2009;23(16):1895-909.
2009: Kazuhiro Kishi; Marcel A T M van Vugt; Ken-Ichi Okamoto; Yasunori Hayashi; Michael B Yaffe
Functional dynamics of Polo-like kinase 1 at the centrosome.
Molecular and cellular biology 2009;29(11):3134-50.
2009: H Christian Reinhardt; Michael B Yaffe
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.
Current opinion in cell biology 2009;21(2):245-55.
2009: Dieter Edbauer; Dongmei Cheng; Matthew N Batterton; Chi-Fong Wang; Duc M Duong; Michael B Yaffe; Junmin Peng; Morgan Sheng
Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody.
Molecular & cellular proteomics : MCP 2009;8(4):681-95.
2009: Jared E Toettcher; Alexander Loewer; Gerard J. Ostheimer; Michael B Yaffe; Bruce Tidor; Galit Lahav
Distinct mechanisms act in concert to mediate cell cycle arrest.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):785-90.
2008: Kevin Janes; H Christian Reinhardt; Michael B Yaffe
Cytokine-induced signaling networks prioritize dynamic range over signal strength.
Cell 2008;135(2):343-54.
2008: Chunling Yi; Erik W Wilker; Michael B Yaffe; Anat Stemmer-Rachamimov; Joseph L Kissil
Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2.
Cancer research 2008;68(19):7932-7.
2008: Xaralabos Varelas; Rui Sakuma; Payman Samavarchi-Tehrani; Raheem Peerani; Balaji M Rao; Joanna Dembowy; Michael B Yaffe; Peter W Zandstra; Jeffrey L Wrana
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
Nature cell biology 2008;10(7):837-48.
2008: Sarah A Bissonnette; Christina M Glazier; Mary Q Stewart; Glenn E Brown; Chris D Ellson; Michael B Yaffe
Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase.
The Journal of biological chemistry 2008;283(4):2108-19.
2008: Martin Lee Miller; Lars Jensen; Francesca Diella; Claus Jørgensen; Michele Tinti; Lei Li; Marilyn Hsiung; Sirlester A Parker; Jennifer Bordeaux; thomas sicheritz-ponten; Marina Olhovsky; Adrian Pasculescu; Jes Alexander; Stefan Knapp; Nikolaj Blom; Peer Bork; Shawn Li; Gianni Cesareni; Tony Pawson; Benjamin E Turk; Michael B Yaffe; Søren Brunak; Rune Linding
Linear motif atlas for phosphorylation-dependent signaling.
Science signaling 2008;1(35):ra2.
2008: Rune Linding; Lars Jensen; Adrian Pasculescu; Marina Olhovsky; Karen Colwill; Peer Bork; Michael B Yaffe; Tony Pawson
NetworKIN: a resource for exploring cellular phosphorylation networks.
Nucleic acids research 2008;36(Database issue):D695-9.
2007: Yu Tian; Robert J Kolb; Jeong-Ho Hong; John Carroll; Dawei Li; John You; Roderick Bronson; Michael B Yaffe; Jing Zhou; Thomas L Benjamin
TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.
Molecular and cellular biology 2007;27(18):6383-95.
2007: Rune Linding; Lars Jensen; Gerard J. Ostheimer; Marcel A T M van Vugt; Claus Jørgensen; Ioana M Miron; Francesca Diella; Karen Colwill; Lorne Taylor; Kelly Elder; Pavel Metalnikov; Vivian Nguyen; Adrian Pasculescu; Jing Jin; Jin Gyoon Park; Leona D Samson; James R Woodgett; Robert B Russell; Peer Bork; Michael B Yaffe; Tony Pawson
Systematic discovery of in vivo phosphorylation networks.
Cell 2007;129(7):1415-26.
2007: Drew M Lowery; Karl R Clauser; Majbrit Hjerrild; Dan Lim; Jes Alexander; Kazuhiro Kishi; Shao-En Ong; Steen Gammeltoft; Steven A Carr; Michael B Yaffe
Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.
The EMBO journal 2007;26(9):2262-73.
2007: Erik W Wilker; Marcel A T M van Vugt; Steven A Artim; Paul H. Huang; Christian P. Petersen; H Christian Reinhardt; Yun Feng; Phillip A Sharp; Nahum Sonenberg; Forest M White; Michael B Yaffe
14-3-3sigma controls mitotic translation to facilitate cytokinesis.
Nature 2007;446(7133):329-32.
2007: H Christian Reinhardt; Aaron S. Aslanian; Jacqueline A Lees; Michael B Yaffe
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.
Cancer cell 2007;11(2):175-89.
2007: Michael B Yaffe; Forest M White
Signaling netwErks get the global treatment.
Genome biology 2007;8(1):202.
2006: Kevin Janes; Michael B Yaffe
Data-driven modelling of signal-transduction networks.
Nature reviews. Molecular cell biology 2006;7(11):820-8.
2006: Al Charest; Erik W Wilker; Margaret E McLaughlin; Keara Lane; Ram Gowda; Shanie Coven; Kevin McMahon; Steven Kovach; Yun Feng; Michael B Yaffe; Tyler Jacks; David E Housman
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.
Cancer research 2006;66(15):7473-81.
2006: Chonghui Cheng; Michael B Yaffe; Phillip A Sharp
A positive feedback loop couples Ras activation and CD44 alternative splicing.
Genes & development 2006;20(13):1715-20.
2006: Michael B Yaffe
"Bits" and pieces.
Science's STKE : signal transduction knowledge environment 2006;2006(340):pe28.
2006: Alexandra K. Gardino; Stephen John Smerdon; Michael B Yaffe
Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms.
Seminars in cancer biology 2006;16(3):173-82.
2006: Orion D Weiner; Maike C Rentel; Alex Ott; Glenn E Brown; Mark Jedrychowski; Michael B Yaffe; Steven P Gygi; Lewis C Cantley; Henry R Bourne; Marc W Kirschner
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
PLoS biology 2006;4(2):e38.
2006: Jeong-Ho Hong; Michael B Yaffe
TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation.
Cell cycle (Georgetown, Tex.) 2006;5(2):176-9.
2005: Manuel Stucki; Julie A Clapperton; Duaa Mohammad; Michael B Yaffe; Stephen John Smerdon; Stephen P Jackson
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.
Cell 2005;123(7):1213-26.
2005: Kevin Janes; John G Albeck; Suzanne Gaudet; Peter K Sorger; Douglas A Lauffenburger; Michael B Yaffe
A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.
Science (New York, N.Y.) 2005;310(5754):1646-53.
2005: Michael B Yaffe
X-ray crystallography and structural biology.
Critical care medicine 2005;33(12 Suppl):S435-40.
2005: Jeong-Ho Hong; Eun Sook Hwang; Michael McManus; Adam Amsterdam; Yu Tian; Ralitsa Kalmukova; Elisabetta Mueller; Thomas Benjamin; Bruce M Spiegelman; Phillip A Sharp; Nancy Hopkins; Michael B Yaffe
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
Science (New York, N.Y.) 2005;309(5737):1074-8.
2005: Leena J Ahonen; Marko J Kallio; John R Daum; Margaret Bolton; Isaac A Manke; Michael B Yaffe; P Todd Stukenberg; Gary J Gorbsky
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores.
Current biology : CB 2005;15(12):1078-89.
2005: Erik W Wilker; Robert A Grant; Stephen C Artim; Michael B Yaffe
A structural basis for 14-3-3sigma functional specificity.
The Journal of biological chemistry 2005;280(19):18891-8.
2005: Gil Blander; Jerzy Olejnik; Edyta Krzymanska-Olejnik; Thomas McDonagh; Marcia Haigis; Michael B Yaffe; Leonard Guarente
SIRT1 shows no substrate specificity in vitro.
The Journal of biological chemistry 2005;280(11):9780-5.
2005: Drew M Lowery; Daniel Lim; Michael B Yaffe
Structure and function of Polo-like kinases.
Oncogene 2005;24(2):248-59.
2005: Isaac A Manke; Anhco Nguyen; Daniel Lim; Mary Q Stewart; Andrew E H Elia; Michael B Yaffe
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.
Molecular cell 2005;17(1):37-48.
2005: Angie S Mah; Andrew E H Elia; Geeta Devgan; Jason Ptacek; Mike Schutkowski; Michael Snyder; Michael B Yaffe; Raymond J Deshaies
Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening.
BMC biochemistry 2005;6():22.
2005: Brian A Joughin; Bruce Tidor; Michael B Yaffe
A computational method for the analysis and prediction of protein:phosphopeptide-binding sites.
Protein science : a publication of the Protein Society 2005;14(1):131-9.
2004: Matthias Krause; Jonathan D Leslie; Mary Stewart; Esther M Lafuente; Ferran Valderrama; Radhika Jagannathan; Geraldine A Strasser; Douglas A Rubinson; Hui Liu; Michael Way; Michael B Yaffe; Vassiliki A Boussiotis; Frank B Gertler
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.
Developmental cell 2004;7(4):571-83.
2004: Erik W Wilker; Michael B Yaffe
14-3-3 Proteins--a focus on cancer and human disease.
Journal of molecular and cellular cardiology 2004;37(3):633-42.
2004: Anhco Nguyen; Deborah M Rothman; Justine R Stehn; Barbara Imperiali; Michael B Yaffe
Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function.
Nature biotechnology 2004;22(8):993-1000.
2004: Glenn E Brown; Mary Q Stewart; Sarah A Bissonnette; Andrew E H Elia; Erik W Wilker; Michael B Yaffe
Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase.
The Journal of biological chemistry 2004;279(26):27059-68.
2004: Julie A Clapperton; Isaac A Manke; Drew M Lowery; Timmy Ho; Lesley F Haire; Michael B Yaffe; Stephen John Smerdon
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.
Nature structural & molecular biology 2004;11(6):512-8.
2004: Sorab N Dalal; Michael B Yaffe; James A DeCaprio
14-3-3 family members act coordinately to regulate mitotic progression.
Cell cycle (Georgetown, Tex.) 2004;3(5):672-7.
2004: Michael B Yaffe
Master of all things phosphorylated.
The Biochemical journal 2004;379(Pt 2):e1-2.
2004: Drew M Lowery; Duaa Mohammad; Andrew E H Elia; Michael B Yaffe
The Polo-box domain: a molecular integrator of mitotic kinase cascades and Polo-like kinase function.
Cell cycle (Georgetown, Tex.) 2004;3(2):128-31.
2004: Michael B Yaffe; Stephen John Smerdon
The use of in vitro peptide-library screens in the analysis of phosphoserine/threonine-binding domain structure and function.
Annual review of biophysics and biomolecular structure 2004;33():225-44.
2004: John C Obenauer; Michael B Yaffe
Computational prediction of protein-protein interactions.
Methods in molecular biology (Clifton, N.J.) 2004;261():445-68.
2004: Michael B Yaffe
Study of substrate specificity of MAPKs using oriented peptide libraries.
Methods in molecular biology (Clifton, N.J.) 2004;250():237-50.
2003: Isaac A Manke; Drew M Lowery; Anhco Nguyen; Michael B Yaffe
BRCT repeats as phosphopeptide-binding modules involved in protein targeting.
Science (New York, N.Y.) 2003;302(5645):636-9.
2003: Andrew E H Elia; Peter Rellos; Lesley F Haire; Jerry W Chao; Frank J Ivins; Katja Höpker; Duaa Mohammad; Lewis C Cantley; Stephen John Smerdon; Michael B Yaffe
The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.
Cell 2003;115(1):83-95.
2003: Joseph L Kissil; Erik W Wilker; Kristen C Johnson; Matthew S Eckman; Michael B Yaffe; Tyler Jacks
Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1.
Molecular cell 2003;12(4):841-9.
2003: M. Eugenio Vázquez; Mark Nitz; Justine R Stehn; Michael B Yaffe; Barbara Imperiali
Fluorescent caged phosphoserine peptides as probes to investigate phosphorylation-dependent protein associations.
Journal of the American Chemical Society 2003;125(34):10150-1.
2003: David W Powell; Madhavi J Rane; Brian A Joughin; Ralitsa Kalmukova; Jeong-Ho Hong; Bruce Tidor; William L Dean; William M Pierce; Klein Jon; Michael B Yaffe; Kenneth R McLeish
Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.
Molecular and cellular biology 2003;23(15):5376-87.
2003: Kevin Janes; John G Albeck; Lili X Peng; Peter K Sorger; Douglas A Lauffenburger; Michael B Yaffe
A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis.
Molecular & cellular proteomics : MCP 2003;2(7):463-73.
2003: John C Obenauer; Lewis C Cantley; Michael B Yaffe
Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs.
Nucleic acids research 2003;31(13):3635-41.
2003: Isaac A Manke; Michael B Yaffe
Chk'n out in mitosis.
Cell cycle (Georgetown, Tex.) 2003;2(3):236-7.
2003: Andrew E H Elia; Lewis C Cantley; Michael B Yaffe
Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.
Science (New York, N.Y.) 2003;299(5610):1228-31.
2003: Michael B Yaffe
Studying the optimal peptide substrate motifs of protein kinase C using oriented peptide libraries.
Methods in molecular biology (Clifton, N.J.) 2003;233():273-85.
2003: Anhco Nguyen; Michael B Yaffe
Proteomics and systems biology approaches to signal transduction in sepsis.
Critical care medicine 2003;31(1 Suppl):S1-6.
2003: Glenn E Brown; Mary Q Stewart; Hui Liu; Vi Luan Ha; Michael B Yaffe
A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase.
Molecular cell 2003;11(1):35-47.
2002: Michael B Yaffe
The p47phox PX domain: two heads are better than one!
Structure (London, England : 1993) 2002;10(10):1288-90.
2002: Barbra A Johnson; Justine R Stehn; Michael B Yaffe; T Keith Blackwell
Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms.
The Journal of biological chemistry 2002;277(20):18029-36.
2002: Jiejin Li; Brandi L Williams; Lesley F Haire; Michal Goldberg; Erik W Wilker; Daniel Durocher; Michael B Yaffe; Stephen P Jackson; Stephen John Smerdon
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.
Molecular cell 2002;9(5):1045-54.
2002: Anne Brunet; Fumihiko Kanai; Justine R Stehn; Jian Xu; Dilara Sarbassova; John V Frangioni; Sorab N Dalal; James A DeCaprio; Michael E Greenberg; Michael B Yaffe
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport.
The Journal of cell biology 2002;156(5):817-28.
2002: Michael B Yaffe
Phosphotyrosine-binding domains in signal transduction.
Nature reviews. Molecular cell biology 2002;3(3):177-86.
2002: Michael B Yaffe
How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis.
FEBS letters 2002;513(1):53-7.
2002: Michael B Yaffe
MAGUK SH3 domains--swapped and stranded by their kinases?
Structure (London, England : 1993) 2002;10(1):3-5.
2001: F Kanai; H Liu; S J Field; H Akbary; T Matsuo; Glenn E Brown; Lewis C Cantley; Michael B Yaffe
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.
Nature cell biology 2001;3(7):675-8.
2001: Michael B Yaffe; GG Leparc; J Lai; T Obata; Stefano Volinia; Lewis C Cantley
A motif-based profile scanning approach for genome-wide prediction of signaling pathways.
Nature biotechnology 2001;19(4):348-53.
2001: Michael B Yaffe; Andrew E H Elia
Phosphoserine/threonine-binding domains.
Current opinion in cell biology 2001;13(2):131-8.
2001: Michael B Yaffe; Stephen John Smerdon
PhosphoSerine/threonine binding domains: you can't pSERious?
Structure (London, England : 1993) 2001;9(3):R33-8.
2000: Fumihiko Kanai; Paola Marignani; Dilara Sarbassova; R Yagi; R A Hall; Mark Donowitz; A Hisaminato; T Fujiwara; Y Ito; Lewis C Cantley; Michael B Yaffe
TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
The EMBO journal 2000;19(24):6778-91.
2000: T Obata; Michael B Yaffe; GG Leparc; E T Piro; H Maegawa; A Kashiwagi; R Kikkawa; Lewis C Cantley
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.
The Journal of biological chemistry 2000;275(46):36108-15.
2000: Daniel Durocher; Ian A Taylor; Dilara Sarbassova; Lesley F Haire; S L Westcott; Stephen P Jackson; Stephen John Smerdon; Michael B Yaffe
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
Molecular cell 2000;6(5):1169-82.
2000: K Nishikawa; Sansana Sawasdikosol; David A Fruman; J Lai; Zhou Songyang; Steven J Burakoff; Michael B Yaffe; Lewis C Cantley
A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase.
Molecular cell 2000;6(4):969-74.
2000: Thomas Benzing; Michael B Yaffe; Thierry Arnould; Lorenz Sellin; Bernhard Schermer; B Schilling; R Schreiber; K Kunzelmann; GG Leparc; Eunjoon Kim; Gerd Walz
14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity.
The Journal of biological chemistry 2000;275(36):28167-72.
2000: Sandeep Robert Datta; A Katsov; L Hu; A Petros; S W Fesik; Michael B Yaffe; Michael E Greenberg
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.
Molecular cell 2000;6(1):41-51.
2000: Mark T Bedford; Adam Frankel; Michael B Yaffe; Steven Clarke; Philip Leder; S Richard
Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains.
The Journal of biological chemistry 2000;275(21):16030-6.
2000: Mark T Bedford; Dilara Sarbassova; Jian Xu; Philip Leder; Michael B Yaffe
A novel pro-Arg motif recognized by WW domains.
The Journal of biological chemistry 2000;275(14):10359-69.
2000: T Obata; G E Brown; Michael B Yaffe
MAP kinase pathways activated by stress: the p38 MAPK pathway.
Critical care medicine 2000;28(4 Suppl):N67-77.
2000: Michael B Yaffe; Mitchell Fink
Cellular signaling in critical care--putting the pieces together.
Critical care medicine 2000;28(4 Suppl):N1-2.
2000: Daniel Durocher; Stephen John Smerdon; Michael B Yaffe; Stephen P Jackson
The FHA domain in DNA repair and checkpoint signaling.
Cold Spring Harbor symposia on quantitative biology 2000;65():423-31.
1999: José Aramburu; Michael B Yaffe; Cristina López-Rodríguez; Lewis C Cantley; Patrick G Hogan; Anjana Rao
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.
Science (New York, N.Y.) 1999;285(5436):2129-33.
1999: Katrin Rittinger; J Budman; J Xu; Stefano Volinia; Lewis C Cantley; Stephen John Smerdon; Steven J Gamblin; Michael B Yaffe
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.
Molecular cell 1999;4(2):153-66.
1999: Michael B Yaffe; J Xu; Peter A Burke; R Armour Forse; Glenn E Brown
Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation.
Surgery 1999;126(2):248-54.
1997: Michael B Yaffe; Katrin Rittinger; Stefano Volinia; Paul Caron; Alastair Aitken; H Leffers; Steven J Gamblin; Stephen John Smerdon; Lewis C Cantley
The structural basis for 14-3-3:phosphopeptide binding specificity.
Cell 1997;91(7):961-71.
1997: Michael B Yaffe; Mike Schutkowski; M Shen; Xiao Zhen Zhou; P Todd Stukenberg; JU Rahfeld; J Xu; Jian Kuang; Marc W Kirschner; Gunter Fischer; Lewis C Cantley; Kun Ping Lu
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism.
Science (New York, N.Y.) 1997;278(5345):1957-60.
1996: Peter A Burke; M Luo; J Zhu; Michael B Yaffe; R Armour Forse
Injury induces rapid changes in hepatocyte nuclear factor-1: DNA binding.
Surgery 1996;120(2):374-80; discussion 380-1.